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<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSU2</accession>
    <name>A0A654DSU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="354"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="590" mass="66705" checksum="E0CA58947C298CDF" modified="2020-04-22" version="1">MSFAVSMAKRMIFFVSGMNGQLLFLGIILVFGSVFLPVIQSRIVKKEAEIRQFHLENRHQQTLITFQESMKGFVTLMSGVRSYMVSNRTMPTQQELKEFLAYQLKDLNYTAPIIFSFVDTSHVFRYSFSQYEDDPGRLIGTSVRDIRSESEIEKLDAVMREESIYLLAPINMVEGMIGIPATFSVVRDEKVLGYVAAIVDFKTLINPIYKAQSTESYAHHFSVGDNVDFDRERIYDGSVSYHTRQDPGFYKNFEISEGAFLYSEVELYGLKFKIGTAAVEQDEQRFNMAILLYGWYLLLIAFVGFSVYRLLHYRKLNVDLNASNAEVESHKVMLEEQNRELQRVVGTKDKLFSIIGHDLRGPLSSIVTMMSESQHNRISPEEKMRFLAGLRDAAKQSLNLLDNLLRWSMVNTGARTLDVRRIDVAMLVTHVTDHLEVMSEAKQILLKSEIADGMELVGDRDMLSTVLRNIVSNAIKFSHDHSVIKIKAYSAGHLAILEVHDSGVGMTSEQVASLFKMDREHVSRGTRDEAGTGLGLIVSHDFIKLHHGSIKVESTEGSGSMFRIILPNQVDEVKKPAYGTGKAILEPSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTG6</accession>
    <name>A0A654DTG6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fmt</name>
        <name evidence="11" type="ORF">MARINOS108_10372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="226"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="331" mass="37135" checksum="BCD0957F9509383D" modified="2020-04-22" version="1">MMYQNMIYKDLMNPLALPAMKEKLRIVFMGTPEFAVPCLKRLVEEGCEVVAVVTAPDKPQGRGKKLGTSPVKDYAVSQGIPLLQPTNLKDQTFQEELKHYNADIQIVVAFRMLPETVWSMPPLGSYNLHASLLPDYRGAAPINWAIINGETETGVTTFKLQHEIDTGNILFQVKEPIHQEDNVGTLYERLMNIGAELVVKTVRALETGDYQLAAQKTPTEAKHAPKIFREHCEIDWNRPTEQVRNFIRGLSPYPAAWTTLDGLTFKVYGAEKSPRNHQSSPGTFHSDGKTYLDVGTANGSLNLTEVQLQGKKRMTVGEFLRGYHWNPPAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTN3</accession>
    <name>A0A654DTN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation:H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="183"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="36515" checksum="9D6F68ED73133A67" modified="2020-04-22" version="1">MTVFINILLVAVGFVLLIKGADFLVNGASSLAKRFNVSDIAIGLTVVAMGTSAPELVVNIISGTVTTDEGTNDIVFGNIIGSNIFNVFLILGISSIIYPLTVQRNALWKEIPYSLLATFIFFILVNDVLFFGAEKNTLNVLDASILLVMFILFLVYIFMNLTRNPDEGELVEDIVIFGSVKTTMMISLGIAGLIFGGKMIVDNAVEIAKTFNVSEKLIGLTILAAGTSLPELATSAVAAFQKKSDLAVGNIVGSNIFNLLLVIGATGLIHSPLGYPPSLNMDLYFCMIGTLMLFIFMFTFAKYKLDRSEGVLYLLGFIVYMYVLFEREGMGFGIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTT7</accession>
    <name>A0A654DTT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022172">
        <property type="entry name" value="DUF3703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12487">
        <property type="entry name" value="DUF3703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14525" checksum="EED2887FC3B85B86" modified="2020-04-22" version="1">MRLYTLMPEKLKPYFYAELKHYRENFSKGNLENAWNHLERAHILGQTYPWHHSYVHWKMLLFGIHIKSGKEILGQIPRLLVGGVKSFVGKIPVGNTGGANIPPLKPLPISDELLSIFKKSGIKNYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTX5</accession>
    <name>A0A654DTX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CMP-N-acetlyneuraminic acid synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="27051" checksum="6F938839D04321FA" modified="2020-04-22" version="1">MMKNLAIIPARGGSKRLLKKNLRLLNGKPLVQYTLEAVVDSGVFDTVILSSDDDDILGIAGNVKGVTPQKREAEMATDKRKVIDLIKDIAERDEVKNTFDTIGLFLPTCPFRTARHIKEGFALLTREDYSVVSITDMSDPVQLTLSMNDENLINPEAVLSPSPLVTGQTRSQDFEKIYRVNGGFYIAWLDKFRQKANFFDGRVKGYYIDKLHSVDIDYELDFEWAEYLLRKNHLSLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU03</accession>
    <name>A0A654DU03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper-exporting P-type ATPase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">copB</name>
        <name evidence="8" type="ORF">MARINOS108_10496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="685" mass="74526" checksum="512B6AF404654FFF" modified="2020-04-22" version="1">MEHQHHNHTHENHNHGHDHHNHDHHSGQHQSHGDHHGHHEHMIEDFKKRFWISLIITLPIIVLAPMIQELLGYQLRFNGDRYVQFILSSVIFFYGGWPFLKGLADEIKKKAPGMMTLIALAISVAYFYSSAVVFGLDGKIFFWELASLIVIMLLGHWIEMKSVMGASNALQELAKMMPSTARRIKEGGEHEDVPIADLKSNDIILVRPGEKVPADGIVVEGESHVNESMLTGESKPVAKKKDNQVIGGSVNDNGTLKIKVKHTGEDSYLSKVIGMVKEAQETKSKTQNLADKAAAWLFYIALGAGVTTLVVWLSIGKDFEYALERMVTVMIISCPHALGLAVPLVVAISTAVSAKNGLLIRNRTAFENARNITAIIFDKTGTLTKGEFGVTRFKSVSDQLSDDDLLQIAASIENSSEHPIAAGIVRKAKSKDLALQEPENFQNITGKGISAKLNGEEIKIVSPGMLKEQGIDAPSDAFKTDDETVVFVLIDNALAGYIALADEVRPESLSAINTLKERGIKVYMATGDNQQVAKAVSEQLSLDDYFAEVLPEDKQRIIKELQQKGEFVAMTGDGVNDAPALAQANVGIAVGSGTDVAAETADIVLVNSNPKDIANLILFGSATYKKMMQNLWWAAGYNILAVPLAAGALASIGIILSPAIGAVLMSLSTVIVALNAQLLKRQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU06</accession>
    <name>A0A654DU06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="31234" checksum="AEBCFEAF94C8A357" modified="2020-04-22" version="1">MSESGNALITGVSTGIGYACCEVFIASGYRVFGSVRTQKDADRLSETFGERFTPLIFDVTDHEAIDLAAITVSKALSDQGLDCLINNAGVALGGPMMHVPIERLREQFEVNVIGLVKVTQAFLPLLGARAGHIGKPGRIINISSVVGQIAMPFLGPYVGSKYALEGISQVMRRELMHYGIDVVVVGPGAIKTPIWNKGMDSLYEDTAFARSLQIFAKGFIRGSIKHGFEPGKLALDIFRIFKKDRPKPRYAIVAKPFLNWWLPKFLPTRMMDRYLAKKLEIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU78</accession>
    <name>A0A654DU78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="37778" checksum="088C004ACA06F12E" modified="2020-04-22" version="1">MHQGVFFSKQEIYLPVYPKLRDTKHLDLSRHILQVFLIVTLMHSAGCESPYDFDSEYTEYLIVDGKVTNIGSEVILSYSGKFDANNSTLKPLTGAEVLLEDDAGASYKFIANTNVYTPPQGFSPKVDETYTLKVLAAGQSIISEPETIHPGFSFHLEAEEVTREVFSPSKVTKMIHGLDIIAHIDSTIPDNTYVKWDYMVLWTHPYTGQLMRESGASQFKVMSSADLKSSGSSSFVVLFWEDIQRYFYAEGVAGLEPAVNFQYHIFVTQTTLSKRAYQYWQQIHAQLKNTGGIFDAILGTIDGNLSIHGADLPVLGYFSAGTAIRQEIVLDDVMILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU90</accession>
    <name>A0A654DU90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024875685" evidence="1">
        <location>
            <begin position="23"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="556" mass="61746" checksum="7378B5EBA41476F1" modified="2020-04-22" version="1">MRNVPYFLFIALFVVGFSPLSAQDIPTGEIEDAQIIIEKDKPLTLPKAGRNYQKTEVLPISSDTVTLRFNLSQPSFKFSPFIYQLQTKPYQVGAEATRNHNYVKAGFGNYLSPLLEGYVGQPIAQGRVGAWVNHESFARGPVNDEKSAYGRSDILLNAVLEGGSIVFEPTFFYEREAYYYYGYKEPIFLSPGALGPITEKVSANHFTLSNVMKSAEESELQWAVKPGVSFTNMATGGNEAFNKESHFDLQGSVDYEMSATIQAGALLGYNYLAYQSGAFSQKRNVLDITPFVRFHEEKVELKAGVKLAVGSDTVNSTGVFVYPDVYAKYQLNDQLGVYAELSGGLNPQTLNNTRLTNRYLEDSLTLLNQNQKIALNAGLQFLFAENLMLQPFIGYSLTQNKMLLAPSEDDSSRFLLTYDQGNFGQVDLGVKVKYITNRTTVTAEMILSGYQPDQALEAWYLPATQVNLKVDQQVGEAIRLHAGVIILDGIKGQETSATGVNFLPAIVDISMGGTYAFSETFSGFLDFKNLLGVEYERYLNYPSRGLTGKLGFIYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUK7</accession>
    <name>A0A654DUK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="451" mass="50325" checksum="08C2BE6A98BB593F" modified="2020-04-22" version="1">MSGKLYSIIDVETTGGTTHSSRVTDISIFVTDGIEVLDEFSSLINPEMFIPGFITQLTGIDNEMVSGAPTFSEVAQQVLDITAGTTFVAHNVNFDFGMISSEFRRLGYAYELPKLCTVRLARQFIPGHRSYGLGKICEDLGIPIHGRHRARGDAEATVELFKIIMQASGGDLNLASEKWVKSLPQQLKREQVDRLPEGAGVYYLYDDQGVPIFIGSAGNLFKKVKTFLVSKARKAMEIKSQLADIDFESTGSELIARLKVMSAIQEHQPVFNHVPNRKSAYSVRMSTDLFGYSHLEVSPLTSRTDNGLIFNTRREGEAYLEKLCKQYELCPQLCGLKPGQRCAEQMCLGACRQLEPAESHNARIRQALSERSFSKSDFVIIEKGMTPNEQAFVMIEDHEYIGYGVVNQELHAVSTLDDFRNYLNSDTASQEKIAIIQTYLSKNKPRVISTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL8</accession>
    <name>A0A654DUL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bglX</name>
        <name evidence="4" type="ORF">MARINOS108_10017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024787587" evidence="2">
        <location>
            <begin position="21"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="680"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="761" mass="83035" checksum="176784A11CEF6255" modified="2020-04-22" version="1">MTKYLSLAIIISIIFGSCTPATETNTISDKTISYKVDSLMSLMTLAEKIGQTNMYNGTWEFTGPIPADNSSQEKAEQIKNGMVGAMINVLSAKATREAQKMAVENSRLGIPLLFGYDVIHGYKTMLPVPLAQAASWSDDAARQGAEIAAREAASAGQHWTFSPMIDVSRDARWGRIMESAGEDPYLSSVMARAWVQGYQGKSLADPVSIAACAKHFAAYGFAEAGRDYNTVDISDQTLYNVVFPPFKAASDAGVATFMNAFNEINGVPATGSTFLQRDILKGAWGFEGFMVSDWGSIGEMVTHGFARDNKHAAELAMNAGSDMDMESRAYERELEGLITEGKVDIVALDDAVKRILKLKYALGLFEDPYRYCDEQREKETLLAVENLQGAREIARKTMVLFKNENNILPLSKEVNSVAVIGQLAGSKDIPLGNWRGQAVTNSAVSLLEGVQSAVSDQSKVAFAEGYILSTGTRDFIHELDIQPGDESGFAEAIRLAKSSEVVIMAVGEDCFQTGEGRSQADIALKGNQQQLLMEVLKVNKNVIVVLMNGRPLAIPEVMDQAPAIIEAWFAGSEAGNAIADVIFGDYNPSGKLPVSFPHHVGQEPLHYDRKNTGRPVTNDFDSGLVFWSHYTDAPTESLLPFGFGLSYSTFEYSNFSVTPKEKGATVTVDVTNSSKIDGTETVQVYVRDVVATVTQPVKRLVDFQQMEVSAGETRKVTFDLSEEDFGFYHKNYDFYAEDGVFDVMIGGNSRDLQSIGVTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX8</accession>
    <name>A0A654DUX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34407" checksum="C8FB5611D0519A52" modified="2020-04-22" version="1">MHYPKRFPHLILLLLVIASCSPEKPATNEEKVSFEGSWNLVAYIPHSEGLTEWNTYSDDILYQKHLTSDHFTWIKYDTKNEQLLGMGGGSYSINTGQYVENIEFFFPPGSSELGQAIPFNFELTDGIWYHTGYAKEMDMDMETGEIVVIDSNKIEEKWIKTSLPPNTNTSVMGTWELTSYLDASQKEFMEYPEFIGYIKLITPTHFTWIYFDKDADEIYASGSGSYRYENGKYSETIDMIYPTNSGQIGETITFKSDIENSKWKHAGYLPNIIIDSTNGDIVRDSILIDEVWALHSDKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV24</accession>
    <name>A0A654DV24_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="11512" checksum="5C82A5D6FA692A5F" modified="2020-04-22" version="1">MTEIIDLILKLSQEIKTIKAYLQQYQKTRLERFNESWIDGQDVMQSLHISKRTLQTLRDNGTLPYSRVNGKFFYKLSDIEKMLEANYQPSKSTGHGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ6</accession>
    <name>A0A654DVJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="25644" checksum="BD9C14F88CA45491" modified="2020-04-22" version="1">MMRNSLILIFLLLLFSCEEEPSAISIAPGYDFFPVEMGQYRTYWVEEINFGAFGGDTSRYFLNEVISDSLVSGDGTVKYLVERFKSTDSIDWKLDSVWTLQRFKETMIVTENNIPYAKLTFPVIAGKSWDGNAFNSQPEKMYYYQALSETAHLQSTGGSEFIEVIIEDIEENIVNQDERSETYAKGIGLVEKDYVTFHFCSANCGELGEIQSGRILKQNLVGYGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK0</accession>
    <name>A0A654DVK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="59"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="325" mass="37000" checksum="31F3A0A28CA8BD41" modified="2020-04-22" version="1">MPVIKKSEYKNPPFYLFNAHLETIVPSMFFKEPNDLYERERLELGDGDFLDLDWIKNNKDRCIVITHGLEGGSERYYVKRTAKFFRDRGWDVMAWNCRSCSGEMNRLPRFYHHGDTEDLSVVIDRVLEEGYESVALVGYSMGGSMSLKYLGEQSRASEIKGGVFFSVPCDLRDSAIQLLKKENRLYEQRFLKKLVEKIRIKAEAHPGVVSSEGLDSLKDFDTFHDRYTAPLHGFQSKDDFFASATCDQYLPGISVPVLIVNAQNDPMLGPACSPYDIAHQSEFVYLETPKKGGHVGFTLPGNAYSYMEKRAEAFIHEQLGISPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL1</accession>
    <name>A0A654DVL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="79" mass="9134" checksum="BCF10BA39A88668F" modified="2020-04-22" version="1">MKVKASNFKNWCTENISPQSWTRICLKCVDEIRAKGYNLKQMEDLDPDVDLDAELLTSLSTALETLYEMSVDESLLIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR0</accession>
    <name>A0A654DVR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfgD</name>
        <name evidence="3" type="ORF">MARINOS108_11162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00014">
        <property type="entry name" value="arsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12930" checksum="BD2C28ECB8742E78" modified="2020-04-22" version="1">MTKIFHNPRCRKSRETLNLLEEKGEQPTIIEYLNTPPTKAELAEIVNMLGIAPEKLIRKGETEYKELFKGKTLSDDEWLDAMVQYPKLIERPIVIKNGKAAIGRPPETVLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR9</accession>
    <name>A0A654DVR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="7">
        <location>
            <begin position="67"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="29498" checksum="319346BB8531C75E" modified="2020-04-22" version="1">MKVLKLNASLIIMIILSGCVASGGRVTSLLFAPSDDKKLGEQVSQEIANNPAEYPVLSESKYPQAYQYLNAMRDKILASNDIDYKSEFAWELKIIQDDQVLNAFATPGGYIYVYTGLIKYLEKADDLAGVMGHEIAHADRRHSIKQLEKQYGLNILLSIALGNEPTQLAQIAAQLAGTGAVLKFSRNAEAEADEYSVKYLGDTPYACNGAASFFQKLLDQGQTGGTPEFLSTHPSPKSRVSDINATAQSAACSTALIKETGMNYAQFKASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW5</accession>
    <name>A0A654DVW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent hydrolase BcerKBAB4_2443</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="20922" checksum="BE103FCFD94A8639" modified="2020-04-22" version="1">MTTEAIEQLKYPVGKFTKPAPITSSHLQHWTDTIGAFPEAVATLTRSLSQQELNWTYRPGGWTIKQVVHHCADSHMNSMMRFKLALTEESPSIRPYHEDRWAELPDSLDDDISNALNLLKGLHGKWVKLISALSDADLQKTYVHPEHGKSFTLAETIGTYDWHCRHHLAHIQLALDHQGRFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW28</accession>
    <name>A0A654DW28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="305" mass="34444" checksum="EFA5E7E9CB43AAAD" modified="2020-04-22" version="1">MKNTFLISLLLVGIHLQCTEAQTIQERLGYNKNTKLLIVHADDLGVSHSENMASFEAIEKGMVTSASILVPAPWFSEVAAYAQSNPDVDFGIHLCLNSEWKHYKWGAVSDPSQVASLLETSGFFPDNGQWVAENADIQEMEQEMRAQIDRAIASGITPTHIDAHMMTAYRRADFVQVLLKISQEYKLPIGVDVKKLKARYPELDFPEMVSLDKLYGAGPEDYEKSLAEYYTTVLRGLSPGLNEILVHTAYDDAEMQAITVDHTNWGSDWRQQDFDFFTSDTCKAILKEENIQLITWKAVQDQLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB6</accession>
    <name>A0A654DWB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13702" checksum="50D2D77579F8C275" modified="2020-04-22" version="1">MKLIARIILIILFTYLLSFVLQWWIIIAISFLVGFALYGNGFNVFISGFLGGGLLWLSYAWYLDIKTSAILSEKIVELFPFNDNIFLIIGAGVVGGLCAGLGALTGNSFRLMFVKRKTKSFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWF1</accession>
    <name>A0A654DWF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11973" checksum="041685FDF93582C5" modified="2020-04-22" version="1">MKTKGGYVYIIANKNRTVLYTGVTSNLYSRVYEHKTGIGSVFTSKYKCTDLLYFQFYDTIIEAIEQEKRMKKWKRSFKENLINSMNPTWRDLFDEIEDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWF6</accession>
    <name>A0A654DWF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="451" mass="50279" checksum="C529A1250E875B13" modified="2020-04-22" version="1">MNKQKFVEYLRTPSNLDTESLGQLEALVNDYPYFQGARTLLAKGSKILKSKNAGANISSAAVYATDRALLKRYINDELIFLSPLTVHESHEADRERDLTDTIKTNRITTAQSKQIAKEEPPKPKPQPKPIIQDEAPAPEPSVPETSKSSDLDHIIDELYRDLEELKINRARFNKIENELAEEEAVDNAVKKATQKTTAAPEPEETKEVTPEPAPSSKEESLEADTPEEPKAEAEPEVAEAVESQQKEEPIAEKADEPQPDTDPEEEKPRDIVRKPSESRSARVSRITEENEPLEPKKTKAESKKVAKKPAKTAKAAGKTKPTTTKQKPESKKKSADTPKKKAQKKDKKKSEEGNKKDDKGEPKRVNQDDIITNFIKSNPSISPASKSAANAQVDLSGASTELHPEIASEYLAEIYLQQGKKDRAVQIYEALIVRFPEKTTYFADIIKKINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR7</accession>
    <name>A0A654DWR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="18400" checksum="335B8433CA1835E0" modified="2020-04-22" version="1">MIQLTKKQEKLQRQVTSKWQFGLFLLTKLPMGLIAGMRLRELDTTRCVTSVPFKYLTKNPFKSTYFAVQSMAAELSTASPCLLAVAGHKPSIAFIIVDLKARFMKKAVDRVYFTCDDCQKAFDAVEQAIATGEAQSATFKTVGKMADGTVVSEFEFTWSFKQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT4</accession>
    <name>A0A654DWT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gliding motility protein GldC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gldC</name>
        <name evidence="1" type="ORF">MARINOS108_11170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019854">
        <property type="entry name" value="Motility-assoc_prot_GldC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19937">
        <property type="entry name" value="GldC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03515">
        <property type="entry name" value="GldC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="12548" checksum="9F03612EB8A11DF0" modified="2020-04-22" version="1">MKKSDINITVELDDQNIPEKITWDADEKDQPGASETKSMSLSLWDEKTKNTLRIDLWTKDMPVEDMKRFYIDCLGGLAQSVLNSTGDEYMSSELNALCDRFVTHLKDEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD2</accession>
    <name>A0A654DXD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="30827" checksum="210CE14CEECCDCDF" modified="2020-04-22" version="1">MIKFSSFISTILLSLLAVSQPKKGLDFPLGEQITFKISYGWFALGEATMSLADSLIVRGDQTFYHSYIDAHTIGLFSWLGGVQNEYWGYVNTSNYKTIVSEKHLDERKGKFDQWNTFDYDKMQTYVKMMDYTKEYPKKEVTVDLNDKSYDLHGTYMYLRSKLWSGFKPGESILLNTYWEDKLYDFGMEYGGKEKIKFDGQRVEVHKFYGLFPISRTFPKEKAVVVWVLEKNGMGIPLVIEADMKIGKVRCELKEYSIRGNTQSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI9</accession>
    <name>A0A654DXI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized oxidoreductase HI_0048</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="29976" checksum="991B2D52F71AD7AA" modified="2020-04-22" version="1">MYPKFEELAGKVAVITGGGGVLCSTMAEMLAAQKVKVAILDLKLENAQQVADKIVQNGGEAIGVEANVLTLESLKRAHQTVVDQLGPCDILINGAGGNHPKGTTSKTHLHLEDLEANDELKTFFDLDPDGVQFVFNLNFIGTLLPTQVFAKDMVGKKGCSIINVSSMNAFTPLTKIPAYSGAKAAVSNFTQWLAVHFAKVNIRVNALAPGFFLTDQNRALLTNAEGSLTDRGNTIIDHTPMGRFGEPEDLLGTLLWLCSDGSKFVTGVVVPIDGGFSAFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ2</accession>
    <name>A0A654DXQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="25056" checksum="2BF051164AAE8C73" modified="2020-04-22" version="1">MIKLNEVDKYIESKYQRVFILKGINLEIQAGEFVSIMGPSGSGKSTLMNIIGMLDKPSQGEYYFLDEPVHLFSERKTSRIHKEHIGFIFQAYHLIDELTVYENIETPLLYRGVKRKERASMVAEMLDRFNMVAKKDLFPEQLSGGQQQLVGVARAIVGKPKLLLADEPTGNLHSSQGEEVMDMLKQFNKEGMTIIQVTHNEKFAEYGSRVIELEDGALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV7</accession>
    <name>A0A654DXV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-galactosidase BoGH2A</fullName>
            <ecNumber evidence="9">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="30"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="186"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="298"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="629"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="8">
        <location>
            <begin position="699"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="806" mass="91127" checksum="894266BAC5E5B36C" modified="2020-04-22" version="1">MKSIKIICGLALLVTLVMSCHTEKGGRKVEDFNHDWQFLLSETDSSSNQPWRNLDLPHDWCIEGSFDPSHPAGVGGGALPGGIGWYKKSFEIGEESRDKKVFIQFDGVYQMSQVWLNGKLLGFRPNGYISFEYDLTPYLRFDKENEILVKVDNGQQPNSRWYSGSGIYRNVRLVTTNPVHVPQYGTYVVTPEVSAHQAKVVVTTSIVNQSAVDQDFQLSTSLVDDNGYEVGSSKRILRLPRDASTEENQEMVIENPQLWSLESPELYRAITTIISDGKVLDVYETSFGIRFFDFDSQKGFSLNGVPTKIKGVCLHHDLGALGAAFNKRAMERQLEIMQGMGVNAIRTSHNPPAPEVLQLCDEMGLLVMDEMFDMWSIKKTEYDYSQYWADWHERDLRDFIRRDRNHPSVIAWSIGNEIMEQYDHSDSTGGVIARELAAIVRSLDSRPITTANNDTSPNNPLIRFGGLDMVGFNYHHEQYEDFPENFPDQVFIATETNSSLATRGYYDMPSDSVRIWPLAWDQKFESGNPGNTVSAYDHVRTPWGSTQEDTWRIIKKNDFMSGMFIWTGFDYLGEPTPYEWPSRSSYFGLVDLAGFPKDSYYMYQSEWTDEPMLHVFPAWTIPASESDRVVDVWAYYNQADEVELFLNGKSLGAKTKKNEEFHVMWRVPFEPGELRAVSRKDGREVLTVINQTADEPYQIALKVDRNEIAADCQDLSFVTVIVSDKQGQLVPYADNLISFDLKGPGKIIGVDNGNPVSHESFKASYRKAFHGLCLAIVQSTESPGEIVLQASGEGLKGATIKILTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX5</accession>
    <name>A0A654DXX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rbsK</name>
        <name evidence="8" type="ORF">MARINOS108_11922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="7">
        <location>
            <begin position="4"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="222"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="32518" checksum="51237878D8372B6D" modified="2020-04-22" version="1">MGNKKILVIGSCNTDMVIKSDRLPIPGETVIGGTFLMNAGGKGANQAVAAARQGGKVTFVSKTGNDVFGKQSIELYNAEGINTDFIFSDAKNSSGVALIMVDSHGENCIAVASGANGSLVPDDIEKAKNELDAADYVLMQLEIPMETVEYAAELAWKKGTPVILNPAPARTLSDKLLKCLFLVTPNETEAEILSGIKVFDFNSAKQAADIISNKGVPNVVITMGAMGAFIKENDEYSLVEATKVDAIDTTAAGDCFSGTLVVGLSEGKTIQEAVRTASKASSITVTRMGAQSSIPYRNELQLIENGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY03</accession>
    <name>A0A654DY03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17298" checksum="4C040B187DE369A5" modified="2020-04-22" version="1">MTTENHAHTVVCQMLIRKPAKVVFEALINPEITVNFWFTKSSGRLETGKTVTWAWEMYNATAEVRVGEIIENRRIAIAWGEPSTSVVFELEAYAPNQTYVVIRHFGFHETGDALIAALKDSTGGFTTLLDGMKAYLEHGIQLHLTGDKFAQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY47</accession>
    <name>A0A654DY47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="32421" checksum="A45A09AB17B2739C" modified="2020-04-22" version="1">MGHNHNHTSKNYGKAFAIGIGLNTLYVAVEAFYGLAVNSSALLADAGHNMSDVFSLILAWAAIWISTKKPSGKYTYGLRKSTILASLFNGLLIIIASGFILWDAIQKIQNPIEVPGNTIIIVASIGLIVNTGTALMFIKGQDDLNIKGAFLHMAADAGVTLAVLIGGLVMKYTGAFWVDPVLSFLIVGVILYGTWGLLSDSVKLAIDAVPEKIDLNEVKHFLEKIECVEEVHDLHIWAMSTTETALTAHLVIPYGCEDQLLYDIREKLHDMFEITHTTLQVEKGWDDDQYRPYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY63</accession>
    <name>A0A654DY63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="32"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="598" mass="68433" checksum="08EAD38A936C8C2B" modified="2020-04-22" version="1">MTVCMLACSTKEYNYKGVHPMKKSNERMVLYQMFTRLFGNTNTTNKPWGTLEENGVGKFKDINAKALGEIRKMGFTHMWYTGVIEHGVLTDYTSFGIPLDDADVVKGRAGSPYAIKDYYDVNPDLAESVPDRMQEFEALIRRTHAANLKVMIDFVPNHVARAYHSDARPEGIIDFGEDDDTTRAFDPNNNFYYLPGEPFKVPEGYQSLGDNDFPTKDGQFAEFPAKATGNDVFSASPSVYDWFETVKLNYGVDYQNNRTTYFDTIPDTWSKMRDILLYWAAKDVDGFRCDMAEMVPVQFWQWVTKEVKEQYPEVVFLAEIYNPHAYREYIQTGGFDYLYDKVEMYDTLKYIIQNKMTTDAITGIWQRQDGIGANMLRFLENHDEQRIASPDFAGDMWKGIPMMAASTFMHTGPVMLYFGQEVGEPGQGVSGFGGDDGRTTIFDYWGVPEHVKWVNNGAYDGGQLSEDQKALREEYIEILKACNNMEAIREGQFYDLHYYNRNDDYTGYSDKVYTFVRHTPSEVLLIVINFDENPQTAKIKIPAPAWETFGINTPVAQISGPVQISIEVASTLDYTDDTDLVIKVSPMNYAIYQMQEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ0</accession>
    <name>A0A654DYQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024848242" evidence="1">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="463" mass="52233" checksum="0DF600AF0CAAD46E" modified="2020-04-22" version="1">MMKKILLPIILLISFMACEQERIGTSEDDNEDIIFDDTDFEATDWTTDTHSNDVDPNFEEVFDDNAVKRLDLVITADRWETMLDDMTSLYGTFGVGRGGNSFSDENPVFVPAEVFYEGTQWYKVGVRFKGNSSLASTWKSGNMKLSFKLDFDEFEDDYPQIKNQRFYGFKKLSLKNNYNDKSMLREKVAGDIFRNAGLVGSHTAFYTLYVDHGEGPVYFGLYTLVEEVDDTVIDTQFANNDGNLYQPDGDGASFASGTFSESVFGKETNEDAADWSDIQNLFTALHADNRTSNAAAWRTSLESVLDTDVFLKYLAVNTVIQNWDTYGRMTHNYFLYNNPETNLLTWIPWDNNEALQTGNMGGSLPLNFSGLSSAQWPLIGYLYADATYKAQYDTYVEEVINGVFNPSDMQATYTTYATLVEPYATSEIRGYSFLNSSSDFQSAVNTLKTHVTQRSAAVAAYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT4</accession>
    <name>A0A654DYT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (Long-chain-fatty-acid--CoA ligase)</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD</name>
        <name evidence="3" type="ORF">MARINOS108_110019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="471"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="562" mass="61462" checksum="8E6D693EB4A44F29" modified="2020-04-22" version="1">MSDKPWLSSYPKGVPQTIDADKYSSLPELFVESRSKYGSKPAYENMGKQITFEELGVLSDQFASYLQNVLKLQPGDKIAIQLPNVLQNPIAMYGALKAGLTVVNTNPLYTASEMKHQFVDSGAKAIVILANFAYNLEAILKDTQIEHVIVTQLGDLLGGLKGALINFVVKRIKKMVPAYQLPTAVTFNEALKQGSAHSFVAPKINPEDLAFLQYTGGTTGVSKGAMLTHRNLIANLQQIEAWLAETNLVEGEEIFIAALPLYHIFALNAHALLPAKLGAKNILITNPRDMKGFVKELKKHPFSLITGVNTLFNGLLNTPGFSELDHSTIKVALAGGMALQRAVFDKWEQTTGKKIAEAYGLTETSPGLCINPMGEGNRVGTIGLPLPETDVLLLDEEGKEVGPGEKGELCTKGPQVFLGYWNKPEETEKCFINGYFKTGDIATMDPDGYFRIVDRKKEMILVSGFNVFPNEVEDAIASHPKVLEVGVIGVPDAKSTEAVKAVIVKKDGSLTEEEIKAFCKENLTGYKCPKHVSFTSELPKSNVGKILRRVIKEEDAKVNTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX3</accession>
    <name>A0A654DYX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="27411" checksum="19CF3222DC9A25AC" modified="2020-04-22" version="1">MACYFAEHRISSILSSHKQDARRNEQTIPNSGLNNQNARSFNAQNMGYYRHWIYDSGNIFHYSQSILGFELSNTACNTDFLCHSYRGNILVEQNYRMNKIQSQIGQAKVLAYVTLTERHEATGNTRHHVDGQLLEGFHGLAICKYSEDPGYYLFYCDENWIERTDTYHNTIEDAKEQAEFEFKGTIQTGNKDKRTTTSVPVAQPLQNLDKIGRLLLSLWKLPPTEIAGGYDDSLTGPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ15</accession>
    <name>A0A654DZ15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="40124" checksum="EF16003AC7E0DF30" modified="2020-04-22" version="1">MTKDKIIPIQLIGTQRSGSNLLRLMLNQLTEITAPHPPHILKTFVPLMDRYGDLSINVNFQNLINDVCKFVELNPVKWNDLSLDRDLIFDQLQHSRNIYSLFEHIYARYASSKGSRFWCCKSLTNVHFAEELHSHGIKPYYIHLYRDGRDVALSFKKIMVGEKHTYHQAKSWKRDQDQALAIGEKLGSERVIRVAYEDLITNPEAQLSRICAFLQIQFKPQALDYFLSRDSQETALSGKMWQNVTKPVLRGNMCKYLKELPREDVLIFEAVAGTTLDRLGYPLHYGDTARAVTFSEVDLINFDRENEFLKKRAVEHSDPLDRAKRMPQEQLLSRIKLAFEPVPLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ78</accession>
    <name>A0A654DZ78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="22070" checksum="0CCE1FC4AFA83412" modified="2020-04-22" version="1">MTIEEVHQLLQNRRSVYPDQYLDKVIPDQIIRNILENANWAPTHKLTEPWRFKVMKGATLKKFGTFMAEKYRSLHGLESFSVAKYEKLKMNPQKAGALIAICMQRDPRKRVPEWEEVASVAMAVQNMWVTSCAYGIGCYWSTPDLLEYFSEFEPLAEEERCIGLFYMGYANPPSGRIKRKPIEEKVKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF2</accession>
    <name>A0A654DZF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024874287" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18714" checksum="A634B75688B7DD6B" modified="2020-04-22" version="1">MKRILMFFLAVTASTALLAQSGDEEMFHFRAMEDKLDDSAIDLAFIRGHFMGEEVAKKLYLLRERYTWVEEESSTNPTPKTYIDKPAIYNSVKKLERYYKKGIKKGYIKEEMAIAEFQQILDIAIFIRNQQTAEFEDLLGQLKEDEQIVGMYTKKVLLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW6</accession>
    <name>A0A654DZW6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CheW-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="20287" checksum="C7E49CB6D72E4ED0" modified="2020-04-22" version="1">MVDGDSTKSHDIAQPEKSWVEAAALGRLNQEISETGTVEKNEVLVVFPVGRERYALPIEKVREVVKAPKIAPVPQAPDYILGVGNVRGNVLAVIDLEKRINPKAPAMEGLEEAFIIVIKDDTYQAGLIVRQVPDTLLVQSSQINTSAAVINNLAPEDHFIKGIVKQDKSMIILVDILEMIEVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A7</accession>
    <name>A0A654E0A7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pdhC</name>
        <name evidence="10" type="ORF">MARINOS108_120093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 2 lipoyl cofactors covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a 24-polypeptide structural core with octahedral symmetry.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="124"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="545" mass="57623" checksum="C041460D67528FD8" modified="2020-04-22" version="1">MAEVIRMPKMSDTMEEGVIASWIKKEGDEVSSGDVLAEVETDKATMELESYQDGVLLYIGIKEQESVAVDGVIAIIGEKGEDISGLLKDIESGGSNGASEKKEEAVDAPATAKAEAVDTSGIKATVIRMPKMSDTMEEGVISAWIKKEGDQVEAGDVLAEVETDKATMELEAYEDGTLLHIAIEDGGSVPIDGVIAIIGEAGADWKTLLKAEAAGGAAPAKTEDKPKEESVSAASAAPEAKAVADTPSSSSNGRLKASPLAKKIAQEKGYDLGQIAGSGDGGRIVKKDVEDFKPSQAAPKAEAKAAEAPAFSIPSVVGEEHSVDVKVTQMRKTIAKRLSESKFTAPHFYITMEINMDKAIAARASMNEMSPVKLSFNDMVVKATAAALRQHPDVNVSWHGDVMKKHSHIHIGVAMALPEGLIVPVIRFADNKSLSHISAEVKDFSQKAKNKQLTPDDYTGNTFTISNLGMFGVEDFTAIVNPPDACILAVGGIKETVIVKNGEMKPGNVMKVTLSCDHRAVDGAVGAAFLKTLKGLLEDPVRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F6</accession>
    <name>A0A654E0F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="3">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="134" mass="14781" checksum="FEA094A569F641DB" modified="2020-04-22" version="1">MVRIEHIGIAVKDLDKANALFQKLFGTPSYKEEVVDSEHVTTSFFGIGPNKVELLQAGAPESAISKYIDKKGEGIHHIAFEVDDILAEMERLESEGFELINKAPKKGADNKLVCFLHPKSTNGVLVELCQEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G8</accession>
    <name>A0A654E0G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024828862" evidence="2">
        <location>
            <begin position="20"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="484"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="541"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="707" mass="75785" checksum="934F8DAE58948A9A" modified="2020-04-22" version="1">MRHTYLLLLFCTIAISALGQNGAVKLNASNTDSYVDAGYNDDYLTEGSYTYQAWIYLEAANTNGYIMATEDDQKGFSFRMSTNDAVEFVHGIPGWHTINSGEVTVPLKTWTHVAATYDGTDLVLLMNGDSVTSNQPAEPMITSTQNLIIGEGATWKERRFTGIIDNVQIWSEARSETAIKESLFEEPAGTETGLIAAWLFNEVSGSTASSAGGAYAATLGNSVTRVSLKEDFSLVFDKSQTPSLVDFGVNASLSPAAPFTIEAMVCPFENNNGYIVSGENGTDGPNGITLRMAGTYGVDFYFGGSGNWNLINSGDNALDSGKWSHVVGTYAEDTLRLYINGSEMAKAYNTNAVGVSTTAFTVGEGSEYRDRGFTGKIDNVRLWNTAIKSGEVLLLKDTIIEEASDDLIAAWAFNEGAGNTTTDVAQVYTGTLSNVTWVQNGYYVTQSTDTENQAPQASATVDIEDGVIGQTFTFDASGSSDRDGDPLTYTWDFGDGNSESGESVSHAYDTEGEYEVVLMVSDGEASSTASLSVSVSVNQNPIAAFTSSATSGFLVLTVDFDASTTVDPEGHELSYDWDFGDGNTGEGVQVTHSFEQVGTFDVVLTVSDSYGGSATESTTVGVLEEQVTLSTDSQVGLQVYPNPVNNFVKIEGLEGAFTYSIIGMDGRVYLSQDTQQTSLNISHLPKGMYLIEISNDKVNISQKVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L3</accession>
    <name>A0A654E0L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="41612" checksum="17879B07403BF52F" modified="2020-04-22" version="1">MKKAILAMTALLLLMHPERGRASTGDTVVIELNNKSKILVYTEDRVALKDLEQYDLNKMIKDLNSALRSSKIEKIELQDDNGKKYLKDTTIIFGEGSSAKTKIKIGNMELLVDADEWEDLDDEWDDDLPVRKYHYEEESIDRTRHYFNIDFGLNNWMEGNSFPDENNAPYAVKPWGSWYFGLNSVNRTWVTGPLFLDWGMGVSWYNWKMQEAATLIEKGDTRIEFNAPPASYSSIKSKLSAPYLNVTMVPMLDFAKGRRKVKNLERGSISFRTYKKQGIRFGAGGYAGYRLGGSTKYVYTENNKREKDKNSGNYYLTNFRYGIRAQVGYKGLDLFAMYDLNEVFASGRGPAGSQGMNAITFGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N4</accession>
    <name>A0A654E0N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IGHMBP2 family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="194"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="633" mass="71973" checksum="C14EF2753F9B89FC" modified="2020-04-22" version="1">MVHSEHFLRLLLLLKKERVEDRKQYESKIRNRSLEDRKKEGVTWYPVVVDSSFLGTGEKWVLKMERTTDHDKRHFFQAGSSVSIFLNDQKKNLSASGIISKVSEKYMTVVLNFDDPPDWIDEGRLGVDLLFDESTYDEMERTMRKLADVREGRIQELISVLLGHTQPGFHQSFGIRHPNLNDSQNEALNLIKSARDLALVHGPPGTGKTTTLVEAIKDTVAEEKQVMVTAASNAAVDLLAEKLTQQGVRVLRIGHPARVTEEVVSSTIDARLAEHADAKLLKDLRKKAEEYRALGKKHKRHFGREERQQRTLLLNEARTLKEDARMLEDHMIHDELNKAEVIACTLVGANSSYLQNRTFKTLFVDEASQALEPASWIPIMKCGRVVMAGDHWQLPPTVKSLEAAKEGLSETVFGRNIAKWDADVMLETQYRMHDDIMRFSNQYFYEGKLKSGDIISQRRQLFEKSVLFIDTAGCGFDEKLNPETLSTYNVEEGRFVLAQLDRILKELPEADAHQLKIGVIAPYKAQSELLKANLPDLGLPGEVLKNITINSVDAFQGQERDIMMISLTRSNAEGIIGFLSNERRMNVAMTRARHLLVMVGDSATLSSNDFFDQLIQDLQQRNLYHSAFEFMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q5</accession>
    <name>A0A654E0Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="286" mass="32590" checksum="E6C408819FEA801C" modified="2020-04-22" version="1">MFIYIPTLEFDQPINNPNQRMKISTESTLDQKIPKGYRVYQIKGVDGSILARKGGPSAEDIKNKATYEELRNNQKEFGVASMMSKVLRNSLSEGMSEICETYVSGRLTAQFRNIATFEEGKSGTRPLYLSKHGHKLNGFEFNTTAPYEDIFGAKYFVKSGSRKGQVILHFPAFIPETTFKKPKEATNFKINARLVALSDYQYDMGQKVYRAVNKEFHGKYGSYESPMLPLLKIPIEPMTAQVSLDLKELPDEMALFLVMAVSFYRYENGKFQHLSKESGMTIKQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R7</accession>
    <name>A0A654E0R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RDD family membrane protein YckC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14626" checksum="7E17E8A2587B85E9" modified="2020-04-22" version="1">MHPVGFWTRLMAHNIDLIVMLPVYYLMSFFIDSNQILIWLCLVVTYLYEVIAIASSWSGTLGKKMMKIKVTNDDLTPVSPWKSALRAFVKAFSVLTLFIGYLTIVLHPQKKSLHDLVMKTSVIFSPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z0</accession>
    <name>A0A654E0Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplD</name>
        <name evidence="7" type="ORF">MARINOS108_120497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="23163" checksum="039D674B7E7BE1AB" modified="2020-04-22" version="1">MKLSVFNIKGEDTGREVTLSKDVFGIEPNQHAVYLEVKQYLANQRQGTHKVKTRNEISGSTRKIKKQKGTGTARAGSIKSPVFRGGGTMFGPEPRDYSFKLNKKVKHLAKKSAFSSKAKDKQIKILEDFSFENPKTQEFAGILANLELNNKKSLLILSEANKNVFLSSRNLKNTKVSTANEISTYDLVNAELVVLLESSVEVIQNTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E109</accession>
    <name>A0A654E109_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14889" checksum="E734DC1FECCE9CB0" modified="2020-04-22" version="1">MNLMISNLNNSVAFYRNLFNRMPVSLSFDTARFTWEEKDILLTETGKRPEVKSCHTVEVHSVEHLHEMYARIKRYISQYDWHSQCKILDKQFAVSDPDGHQWIIKQGEVEINCSIADYCFLEQTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E160</accession>
    <name>A0A654E160_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L,D-transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="88"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="25730" checksum="224D5C76404C076B" modified="2020-04-22" version="1">MTEEIVPEIPVTVDRRKRVLTWAGYGLLTFILLLTLPWLIEKSTLAILSSPPANEMEEAAVSDLTLQLQSDLEKLEKKLAGKTPKGAYMIVNTAANTFALYRGSELIHADKCSTGSYILLKNGDNQQWMFKTPKGEFKIRSRTVAPVWKKPDWAFVEDGLPIPSMNHSSRFEYGVLGDYALGLGDGYLIHGTLYQRFLGLPVTHGCIRLNDANLKLAYESLKTGSKVYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y2</accession>
    <name>A0A654E1Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20 family molecular chaperone IbpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14621" checksum="28C8F56FA888A6B5" modified="2020-04-22" version="1">MRVEDRMLIKNLAHTAEIVNTINGGMTEPVINIDKKETEWIVKVRVPGVSAEHLKIEVRDYEMFLFHIISEETTADIELPYLLSAIKLTSQVDFDGIMAEYQAGELSIHLPLDETASGYERDIEIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E202</accession>
    <name>A0A654E202_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein assembly factor BamA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Omp85" evidence="2">
        <location>
            <begin position="440"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="824" mass="94185" checksum="1E6A5A808141B7D7" modified="2020-04-22" version="1">MGELGLKIKILLLFITVSVSSCIGTKYLKKDETILYKQNIKSVGPINEESLQTQLTQTPNSRLLGLPIAHLVHVYKWGESNLDSAKLLRKRERITLKYDKKIAGAKSDSRKTKLTSKKIQKTEKIEKTLREGNQLMRWGEQLAVFDSTQLINSTINLRNYLFSKGYFNAKISTNVTHRNQRTFVTYKILESKPYTIDSIVYKIQDKQVKSLFEANINQQKMVGKQYDQELFGKERDRVYDLMSNNGYYDFKKQYVLFEVDSTQLDDRRLLIRENIANPPGKSQHRTFRMDSVIFSNETALTNSQNRQTEEYHDITYSFTNDKYPERLLSWRIFLEKDSLYSKQNTLETQKQLSYLDIFKFVNINYDSSGGEFIANIFTSPLKKYQTSTDMGLSVLEHAQGPPGPFFNFNAKSRNVFGGLEIIQLDGNASIQGIKSVSEDNTNYSRFQYGGQLSVTFPQFLFPMRESQRAAIGRYNPRTKIATGVNFEDRKDEYTRTTFNGSMSYIWQVKESTQFTLKPFDLSYINSINSDSFTDTLKALEDSGNQSLVSSFQSSFVSFTSFSTQFNQNNYGLGGRTNSGLWQGYIETGGNLQSILGKKPLSNSFDSLEYYHYVKASVDVRRTNRLSSKSSLAYRLNLGMAYAYGSNKALPYEKYFFAGGSNSIRAWQPRRLGPGAYAVYSTSDDGGDIEVNNSREQPGDIIMEASVEFRRDLVGFIDYALFIDAGNIWLWNSETVEKETDGYGNGTNDDGVFRLKTFPKEIAVGAGFGLRFDFSFLVLRTDIAYKMVDPAYPMGQRFILGDYQLNDLWDFKNRAAVNIGIGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E260</accession>
    <name>A0A654E260_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized transporter HI_0883</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="48170" checksum="7AAD51DBF20D8D83" modified="2020-04-22" version="1">MSVLERFFQDAANFIWGTPLLILLLGGGVFFMFYSRFLPFRYFGHAINVLRGKYDDPSDPGDINHFQALSGALAATIGMGNISGVAVAIAMGGPGAIFWMWVSAFFGMATKFFTCTLSVMYRGKDSAGNLQGGPMYYIREGLGKKWMPLASFFAVVGFFGATPIFQANQIVQATKDILFVPNGIALDNIYLDLGLGVFIAILVGLVIFGGITRIGSVAGKLVPSMVLLYVASVIIILIVNYGEVWSSLGLIFTDAFTANSVLGGAVGALIITGARRAAFSNEAGIGTAPMMHGAAKTKEPVREGLVAMLGPAIDTLVICTMTGLCILVTGAWKSGDLNGISLTAKAFGDSLPGVGPYILALCVLIFAFTTLFGFAYYGQKCLSFLIGARYASLFNYWYVFLILVGSVATLQGVVAFIDVAYGLMAFPTMIGAIVLAPKALKAAKVYFSGVKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E286</accession>
    <name>A0A654E286_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="15483" checksum="4776C5A63F04C6BC" modified="2020-04-22" version="1">MKKDIQFPQIEKVFVSVVREKDAEQWRVYLLNRSDKHLDTVMVTSKGYGIKGGEEQKTSVLRHMIPRIESGEYALIEPIDEQVFHLNNEYWVSFFIDGQLYDKKYIFVPETIIKENLSYIDELQTEGVLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A5</accession>
    <name>A0A654E2A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="38057" checksum="45367F828E773502" modified="2020-04-22" version="1">MLLTLFSGENEGLLFGVFGVIIILFLLVDLGFFHKAHQKVTQREALLQSLFWVAVSVCYGMVIYFYGEGPTASFEFFSAYVTEKALSIDNIFVILLILRYFNVKEEYYHNILFWGILGAIVFRAIFIFVGAFLIAQFHWILYIFGAFLIYSGVKIFSEEGDMEIEPEKNPVMKWAKKIFPFTTNTADGKFWVKENGKRLFTPLFLVIILIESTDLIFAVDSIPAAFAISQNEFVIYTSNIFAVMGLRAMFFLLANVLDKFYLLQKGLSVVLIFIGAKMMLEMEILQDALGTIFGVEHITIPIFLSFGVIIFLLFASIVLSLIFPKKPELVESEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I1</accession>
    <name>A0A654E2I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="224"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="34888" checksum="98EC2DC1C5CF74F6" modified="2020-04-22" version="1">MLGFLLMVLLGLYSSAQEKNDQVTVKITKDIDGDTQTFEKTYASEEEMKADAELKEFMGKDDQMRVWFSEDAKGPKIIELEEMGDDPHRFFFKFGDEDMAQNFHFFESGDSAMSFDIEMERLGDEFRSMEKTIRRHFESADGHRSMAFSFGGDDDKFDWHFSDSLSAEIREKMDRARAESRRGHRDFEVRVLKKVAISDDVEAFGKKGAVKTSDQLNLNDLRYFPNPAPDGRFHLKFDTPEPGELSIKIYNTNGKEVFNRYFEKYGGRYSEMIDLSQQSEGIYLLEISMDGKRLTRKIAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K8</accession>
    <name>A0A654E2K8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable inosine/xanthosine triphosphatase</fullName>
            <shortName evidence="3">ITPase/XTPase</shortName>
            <ecNumber evidence="3">3.6.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Non-canonical purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Non-standard purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Nucleoside-triphosphate phosphatase</fullName>
            <shortName evidence="3">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + ITP = H(+) + IDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + XTP = H(+) + phosphate + XDP</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YjjX NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.73" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00648">
        <property type="entry name" value="Non_canon_purine_NTPase_YjjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002786">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00258">
        <property type="entry name" value="TIGR00258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTPase_I-T" evidence="5">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="19127" checksum="D02D892B54B4CA9B" modified="2020-04-22" version="1">MQVVVASKNPVKINATQEGFRKIFPKGELSVTGLSVPSGVSDQPMTDEETLQGAANRAQNARHEQPDADYWVGIEGGLDETPQGLIAFAWVVILSQNQMGQSRTSTFHLPPKVTELIHQGIELGHANDQVFGEKNSKQKGGAVGSLTGGVLGRTEYYVQAVMLALVPFKNPEIYPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L1</accession>
    <name>A0A654E2L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-ser_dehydrat" evidence="2">
        <location>
            <begin position="244"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="361" mass="39928" checksum="DC2EF7941C07D682" modified="2020-04-22" version="1">MKITKPTLLIDETKVRKNIRIMAEKARKSDAILRPHFKTHQSATIGRWFAEEGITCATVSSVDMARYFADAGWKDLTIAFPYNPLEAEAIQKLASEIRLNVLIVSKEALEHLNNHVDAPVGYFIKLDVGTHRTGVMPDNFTEIQAMAKSNQPHHVLKGLLAHAGHTYQPLTREEASKIYHQSLAAFDQVSRAIGRKDLIYSYGDTPSCSLVDDFSAVQELRPGNFAFYDVMQHHFGSCALEDIAVCMACPVVSIHPDRGEVVVYGGGVHFSKDFIQVSDRRVFGTVVSTDGMGWETTPLATVDRLSQEHGIIRGSSDFINSVRIGDLVGILPVHSCMAADLQGYYVSLAGQRIEKLNKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P0</accession>
    <name>A0A654E2P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_130004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="746"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="962"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="548"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1086" mass="121419" checksum="A4616655F646D110" modified="2020-04-22" version="1">MSDKDMNLTQGQAQDIIDITELINPFPGLRPFGIEEGHLFFGREGQSDEVLVKLAENKFVGILGASGSGKSSFMYCGLVPSLVGGFMTEAGSNWRVVVARPGGGPIDNLAEALLIKDKEYSNLSEEDKLIKKTIIGTVLRSSSLGLVEVIKQLKTDNDQNMLIVIDQFEELFRFRKLEAATSDMDESSAFVNLLLEAIHQFDEPIYITITMRSDFIGECAKFPDLTQMINDSHYLIPQMTRDQKRVAIEGPVAVGGGKIAPRLTQQLLNDVGDNPDQLPILQHALMRTWANWVDTRKPNELMDLRHYNAIGTLREALSQHANEAYDSLSKREKEICEVMFKSLTERGNENQGIRRPTKLGTIAAIAGVTEDEVSRVVEKFREPGRSLLMPPYGVRLDTETVIDISHESLMRIWDRLKRWLDEESKAAEMYLKLSEAAERFQEGKASLWKMPDLQLAINWREENRPTLIWGQRYNPAFERTMVFLETSEKAYVTEQRNKELLQKRQVKRMRLSAIILGAAALVSIFFVVYANIKSNEAQKASEEAKVQQELAVKNADDAEKQAALAEEQAALARKAENKATAALKEAEVAKIEAELQADIAKKQKAEADKQRQAAEEAQIEAAESAEQAKIEAEKARQAQAEALVAKDNADRLRLQSVAQSMAIKARNIPERELKAVVAKQAYDFYQQYGDPNKPYNGDIYAGVYSGLEGVLSTYSVNDDGEKVFKNNGDSVLNQYHGHLPVTTSQVTEEKISVRSVVFSEDGKRMYSAGSDGRLLMWDYASGKRTYVEIFHRNHVNRVVNVSPNERYLALGTDDNHILVVDLKNRDSEPVSINGHVGGTVYDLVFLPDNLSFISTGADSRILLHSLRTKETVQIAQTSSRAKTLAISPDAKTLAAGTESGEVMIIDLNGTDYPSRNIYRKNGSPAVHALHFSNGADKLAFGDDKGDLFIWDLVEKKQWGPKLTGFTSPISDIHFSPDDDLLAATSKDKTARMWDLNNIYDLPTVFDDHKDWVWSLDFHPSGQQFATGSADGIIRVFETKPDAYAERICGLVSANMSETQWRQYVGDLEQIPYEYTCDGLDKGDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U0</accession>
    <name>A0A654E2U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="27272" checksum="B49FE92C149A5D42" modified="2020-04-22" version="1">MYINLSGLNILVTGASRGIGKAVATKLAEAGATIAIHYNKNVREAENLAHILGNESKAFQADLSLPDEASKLFDRIALEMGSIEIVINNAGVAIPAPINASEEDWQKAWDDTMMVNLTSPAVICRKAIDHFLKRKSSGRIINISSRAAFRGDQAEYMAYAASKAGLVSLTKSIARAYGKDGIKAFVIAPGFVRTDMAKEFMDMYGEEHTKGDVALERLTEPKDLAPLITFIASGMADHSTGSTFDINAGSYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y5</accession>
    <name>A0A654E2Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024885172" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="17296" checksum="D95C4803DD1F3F70" modified="2020-04-22" version="1">MKNPIQLLSLCLLTLALFSCSEDPDDVKVVDQKGMLTVDISGTSTMNFEDDTLTAYTHAGLFIVKASDLEENNIWIMMDMTQIDNMIGEHTVARTGAEVQINFNLGDGSNYYSATTGVVTVTKYDETFIKGTFSFDAIDAGDASATISATNGQFESTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E300</accession>
    <name>A0A654E300_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpF</name>
        <name evidence="14" type="ORF">MARINOS108_140115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD17615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="20466" checksum="91BBEB9C41F52FFF" modified="2020-04-22" version="1">MFALGIKTRFLFQTFNETDVELVTPGIGLIFWQTVVFLIVFLILAVFVWKPIAGALKARESQIDDALKAADLAKEEMEQIKSDNEYLLQEARAERDKILKEATDTAIQIKEQAKSETSAIAEKLIAEAKASIETEKRAALAEVKNLVAGLSVEIAEKLLREKLSDDKSQKALIDKFLKEVKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E318</accession>
    <name>A0A654E318_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GWxTD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030959">
        <property type="entry name" value="GWxTD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20094">
        <property type="entry name" value="GWxTD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04514">
        <property type="entry name" value="GWxTD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GWxTD_dom" evidence="1">
        <location>
            <begin position="216"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="382" mass="43923" checksum="927E585E06F0310B" modified="2020-04-22" version="1">MQRQRSGFLIFLICLASVSHALDLSRINLGFQYDLSAGMTISHRVVEVNEGVAVYFRVSTDSLGAWQSHFLLQERYNSLKHDTLSNYTLDTLQISLSSGYFKLTLPQSSKALLLISMVDLNRGLYRIGDVRISTPVGFTPNLPLDERGLPIFDSYVTGESVRIAGEVGELHAYQYLDDFGSADPPMGLMKPIAPSLSIDSSFYFEGELVSMENYHFYLIQEDTLAQTALTLLKCPAYYPEFKRLDELIGPLTYITTPTELKAISDSQSKKIFENFWLNTYGTKFRAKNAIRVFYKQVEDANRLFTDYKQGWKTDRGMIYIIFGLPDQVFRNESTEVWKYNDGPEFEFIRISTLFTPTMYTLKRDRQYERLWYSQVGDLRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E328</accession>
    <name>A0A654E328_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="706" mass="80127" checksum="A1C897A29CFFD8E5" modified="2020-04-22" version="1">MALFFSGLAGFAGELRIITSGGLQGVANDQGQVVVPAIYEKLGWSNGQSDITSESIGYFENGKWGLINIKTTKLTNARYTTLEPFNDLLFEAGIAGKFTNIIFRGLIDSKSQVHLDFKYYTIDDLGDHRLLVSEYVTGGELRFGVYTDQNERLIAPEYASIDREGNYILARNKARKARIYNLNGQVVLPVWVDEVKPTSEGLVVINEGYQGFLDHHGKLIHELTYKSVEDLVKFPRWEVKKLNGAEQRFFLCDSLSYDYETDLLIAHVNNAEHMLGASETLFQDQQHGLKYISNGFLVTRNKYLQTWGIYKTDGREVAIGFDSVAVDADYFYAKSGASWDVYNLFGRKINDRPFQQVRSSQERHVPVRKNDYWGWVDFQGEQLINYHFEDVIPTTNPGHFMAKNYGRWGVSGFDDEWLIMPQYDSVYAYQSFYLAERGFATHVYSLGGKLLYELPYTLMPGDFLAVQDSASVGAVTDQGYYIYPEYDEVSRHGEFFELRKGTITGLISGTGRVLLGPKDAVEDVLSYSEGYFHIIKDGKHGFVDENGKLRIANRYDSAQYYHEGLAPVKLLGKWGFVDPAENLVIQPFYRYSSVFDHGLAVIQSGEHFGIINQEGEEVIAPVWKYIERLTTGNYRITDWDMKMGLVDANGKFIVRPNYGSIEDTDQALIIAGRSGKKGVLDYSGFTKVPFDYQQIQIVGDYLLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A6</accession>
    <name>A0A654E3A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12487" checksum="082A285B01FF506E" modified="2020-04-22" version="1">MKGTNLGEFEEVVLLTIASLMDEAYSVNIVDEIEKVTGRATKLGVVHAVLKRLEDKGYISSELGEPTKERGGRRKRFFKISHSGKVSLLKAREQRDQLWNTIPDVVFEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D7</accession>
    <name>A0A654E3D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glnB</name>
        <name evidence="1" type="ORF">MARINOS108_110128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="12678" checksum="225B65F8167FB801" modified="2020-04-22" version="1">MKLIIAIIRENQLDQVRESLIEAGIARITVSNVSGHGRRITEEIYRGQKVIPTMVSNIRLEIAVNDEFKERTIDAITRATESNDGEMVGSGKIFVVPLEECIRIRTGEKGNAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F1</accession>
    <name>A0A654E3F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine-phosphate diphosphorylase</fullName>
            <ecNumber evidence="2">2.5.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="22343" checksum="8AC2A7E667F16D8B" modified="2020-04-22" version="1">MEMKPKLKGVYLVLDPAEGFDALENRLLHILSGGIGAIQVWDHWHPDQDRHEFLYRLQAVCGQVPILINNNLELASLPGIQGVHFDREEDLPSPECTFKKIIGLTVSTHADWVALRKKGVDYISFCAMYPSSSVDTCELVSPDVVREACEHFDGSVFASGGISLENAGVIASLGVSGVALISALWKAENPLDTTIKFNQIISKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G7</accession>
    <name>A0A654E3G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="14696" checksum="19406893DE5F648C" modified="2020-04-22" version="1">MKSHQSVLIALLLVIQALGPISDLCCELPKLPNLISHFYEHRAFDNDSFLEFLAEDYFEGTGDEQGHHEDDNHDNLPFHGNHHCGHIFVFVTPVLTQQLKSPSFSTVSNFCIYLAPTSTAYPDSPFQPPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M2</accession>
    <name>A0A654E3M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15796" checksum="53A0ED2DEDF1BD88" modified="2020-04-22" version="1">MYQQEVKIRVRYAETDQMGYVYYGNYATYYEVARVEAFRSLGFPYKKLEEMGIGMPVLSLNVNYHQPAKYDDLLTILVSIPERPRARIKFHYEVTNEAGKLINTGATELVFIKMDTGRPVRLPEVMDKLIQPHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N9</accession>
    <name>A0A654E3N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="65"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="28488" checksum="461A613C2B18DF21" modified="2020-04-22" version="1">MHIKEQDGFRFIDEGEGEVLLLLHGLFGALSNWDGVVQRFSSNYRVMIPLLPIYTMPVREAGLDTLNKFVEDFVEKQNLSGLNIIGNSLGGHIGLIFTLKNQEKVNSLILTGSSGLFENSMGGSYPKRGSYEYIQERVAYTFYDPKTATKELVDEVFETTKSIPKALRIVAIAKSAQRHNMADDIPNIKVPTLLIWGLNDTITPPYVGHEFDRLIPNTTLRFIDKCCHAPMMERPEEFNEILETFLMKEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q4</accession>
    <name>A0A654E3Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="466" mass="54493" checksum="36E8B91A5E90EF05" modified="2020-04-22" version="1">MQEEYKRKEERELVRKFEAFLKNKEPFYFDEETFLQVISYYQNHEKYNQALKACEVALEQYPYSVDMLMELADVLVKLDRQDDAIEKLEEALNYHPNDPELLMQKGTIHSLLSEYQDAVECYQKTLDFAEDKDEVYYSIGLAFQGMGNYEAAAENYKQAIEFNMLNENALYELAYCLDVSGELESSLDYYHKFIDQDPYSEYAWYNLGIVYNKLEQFEKSIDAYEYAVAIDDDFSSAHFNMGNAYMSLEQYDKALNAYTKTMDIEGPTSETYCHIGAAYEKMEQLELAVKNYQKATKLDHLYHEAWYGLGICLGLQEKWYEAIHFLNKALKLDVENGIYWKAVADAEAKMGNIVSALEAYAEASEMDPENPQVWLDWSNVYYEQGDFQLAQDTVEEGLAECPDDADLFYRSVVYLIEGGKYKMAINRLETALILDFEGHLQLFDYFPNLHTQKALYKIIEQYRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A4</accession>
    <name>A0A654E4A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="94" mass="10874" checksum="DD5EDE52EB23AC68" modified="2020-04-22" version="1">MAELSIKLKIGNREYPMRVKAEDEERIRRAGKMLNEKIKSYRNQFGIEDNQDLLAMVAFDCLVDKMKNEETIESTDEVALDQLRNISQLIANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A8</accession>
    <name>A0A654E4A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="79" mass="9178" checksum="ABD1F872F2566809" modified="2020-04-22" version="1">MQELLAFVHSIYNQTLATMITIDNDPNEDQMTLECALKIVQHLEKNIVRHRENINMASKLASMNKFIQMNYIHNMAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J2</accession>
    <name>A0A654E4J2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="58"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="361" mass="39881" checksum="0DB063F2299E692E" modified="2020-04-22" version="1">MKGKILLSLGLVLLFLFSTIDAEAQRRNKYRKRKNKNKSISRYHGGSVGGKFRPYSFLSGNVNALNYYGDLAPVNKAASTDISFTQPGFGVNVGYKFSPYAAVRAGFNYGRLKGDDISSDPAETQAYPRYLRNLSFRNDIKEFHMGFEIFLLPNYGGPNIRPPFNVYLFVGGAVFHHEPKGLVPDMDYTTGGTEVAPSAGEWVKLRKLGTEGQFLDGSDVKKYSPFQLSIPLAIGATFRLPGPFDVGLELGYRYLFTDYVDDVSTNYVPFDQFDDPLARIMSDRSAEPVAAWSGIDRSGVKIASSTMSDGVEYYSSVDLGGGRDDTGEGIRGNSKDNDMMFMTTLKLIWIVGKTGSSAKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M3</accession>
    <name>A0A654E4M3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlC</name>
        <name evidence="4" type="ORF">MARINOS108_20554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="20195" checksum="E0EA889DB5CB8893" modified="2020-04-22" version="1">MEVIETALKDCFIIKTKVFGDERGFFLESFNQKGLAEQGIHFDVKQINFAKSEKNVLRGLHYQVAPFGQTKLVGVISGAVVDVVVDIRKSSPTFGQSLKIEISTQDTFLLIPKGFAHGYYTLADETIFYYAVDNSYSPESERGIIYNDPDLNIDWGINGTPKISTKDQHQSLMSKAELFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P3</accession>
    <name>A0A654E4P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndk</name>
        <name evidence="3" type="ORF">MARINOS108_60131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="2">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15009" checksum="9D4028D7510F9D7D" modified="2020-04-22" version="1">MAGTRTFTMIKPDAYGSGNTGAITKMIEEAGFGIKAMKLTHLSAGRAGQFYAVHKERPFYNDLVTYMSSGPIVAMILEKDNAVEDFRKLIGATNPADAAEGTIRKIFATSIEANAIHGSDSDENAEIEGSFFFSGLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S3</accession>
    <name>A0A654E4S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RagB/SusD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025071703" evidence="5">
        <location>
            <begin position="25"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="360"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="522" mass="59701" checksum="13EEB544236B4103" modified="2020-04-22" version="1">MTLRAMKTMRKILLLSIITTVLVACDEDKFLDITNQNELVAENFYTNITNFNNALNGVYSATKSLDLFGQAFYIQTLLALPHTSDYWNAQCRNEVTSGDGNMYIAWRGWYRVVSRANDLLENAPIYLENESPNEAQKAELAQIVGQAHFFRAFAYFHLVRLWGEAGYAEDSTRLAVPLHLKVPTTRDEMMKPRATVGQVYRQIVADFEIAESLLPTSWNDDNIARATSYAAKGFLGKVHLYMQDYATAKTYFEEVIGSSAFALGSFEEYDQMFQGKLEFGPETIFELNYGIDMQQNIWENGLGSGIALTLAPPGRGWSNCTPHGVNIFRFGDDPRLKICTYAPEDSAANVDGIMEPVGKSEFNYTGHSFRKYVPEDYSVYSTNRNSGINFIIMRLSDVYLMYAEVLNHTGNDVLASEYMNKVRRRAYSLDPETPEPTVDYTGLGGVQLQDSIREERFRELFAEGHRWYDITRWKIVEEEVTKYNDFRVTQGEIIYQDRDYYYPIPLQEVDNNTNMTPSTGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E514</accession>
    <name>A0A654E514_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046239">
        <property type="entry name" value="DUF6272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19788">
        <property type="entry name" value="DUF6272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="23059" checksum="9B5D588610B0EEB2" modified="2020-04-22" version="1">MENSTGESENTLSRQLRYLQSVITLKDMMDEENLNIVYLGRVTQSTIDGIADMTKEGISEKGENSLVTKRVYHVMIESLQNICKHADSKASYTSDSLEEGLAKEGVFLIGDNETEYFVTTGNRISMPNAIRLRDVLDKINELDRDEIKALYKTAMMNSELSEKGGAGLGFIDMAKKTGTKYEYYFEPLDNESCFFILTIRISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E582</accession>
    <name>A0A654E582_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusC/RagA family TonB-linked outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024825910" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="116"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="454"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114230" checksum="3E8A03F06B25B617" modified="2020-04-22" version="1">MKRILLLSFMLTFVFAFSALAQRTVSGTVTSAEDGSGIPGVNVVLKGTTTGTTSDLDGNYRLSVPEEGGTLVFSFVGLEPKEVEIGARSVIDVGMSSDVQQLTEVVVTALGIERQEKSLTYAVQDVKGDGLTQARETNIVNSLSGQVAGVQVTSSSGTPGASSRVVLRGASTISGSNQPLFVVDGVPIDNSNYGTAGNGGGYDLPNGAASLNPDDVESISVLKGPVAAALYGNRGANGVILVTTKTGKGKKGLGVSVNSSTMFQTPLRLQDFQNSYGQGASNTYFEFVNGQSGYGDGVDESWGAPLDVGLEFVQWSDYRDDGTTSSPSPWKSYPNNIKDFYETGVQLSNNVAIAGSDGDNAFRLSATNMNQTGMVPNTDFNRWNINSSASLRLLEGLEASFSANYIKEHADNLASIGYTNDNPVQQMIWSGRNVDLAALKDYKNLPLSPEGTAAAGTPLNWNTVFQNNPYWGQDVNLQGYDKDRLIGNVKLAYQFNDWLSAYVRTGIDNWDMRNSNIKAIGTNSAADGFYSDQVRRFTEINHFYMITANKTFGDFGVAVSFGGNNMIQEYTRHYVGVPALELPGLYNVSNLKSGSTPTLINTLEEEKINSLLGTAQLSFRDFVFLDISGRNDWWSVLPKADNSYFYPSASLSFVLTDMLDIYSNALPYLKVRAGWSKVGSSGGLNPYSLQQLYSFRTTPYGSVSLAYNPETLNNPNIKPETTTGIEIGLAAKFFDGRISLDATYYDQTSEDLIVQVEVSPTSGYESAYDNVGLIENKGIELQLGATIVDTKDFSAGLNVNFATYNNDVISVNNIDGDEGAIVLGGQWNVDLQAREGHPYGVLFGPGYLKDEDGNIVHVNGRPQIDPTYRVLGDIQPDWTGGIAVNLRYKGLSLSSLFDAKWGGDIYTMTTTWGRYAGVLAETLKGREEGIVGKGVMQSGTDTDGNPIYVPNNIVVTAETYNKAAFSNGVAEGSVFDASYIKLRQVTLNWKLPSQWFTNVPFKDVNIALVGRNLALLYSKVPHIDPESGFSNADSQQGQEFGQLPSARSMGFNINFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A1</accession>
    <name>A0A654E5A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tilS</name>
        <name evidence="9" type="ORF">MARINOS108_90146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="362"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="440" mass="49606" checksum="D7E2D9BE6E932890" modified="2020-04-22" version="1">MYQSFLTLIKENALIAQEDKVLIAVSGGVDSMVLAHLMLKSGFSIGVAHVNYRLRGDDSEEDEALVRDWCHAHEVPFFLHRVDPAIYDARESIQMVARKERYSFFDQLRNKQGFTKVATAHNANDNLETVLLNLTKGTGIHGLTGIAIEGPGLIRPLLFATKEEIYAFARSEAISWREDVSNQNNDYQRNLIRNEVVPLLKKINPALESTLQDTLLRLQGTAQLLEQAVEVKKAVETEGRWLLNVEWYRGHPDQLVILTELIKPYGFGFADARDLSGAILSGQPGKIFYSSGYEMNLDRGQLYITRRVDTSVEGEVMVPKDEGTVSVGTFNIHLTYFSGNELPPHDPTTTAFFDPDELTFPLKLRLWKQGDAFYPLGMAGKKKVSDFMIDSKIPVTLKKEVLVLESDGQIAWIVGHRIDNRFKVTSKTARMLKLEVLRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E609</accession>
    <name>A0A654E609_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="33287" checksum="981B81B6C2F04FE2" modified="2020-04-22" version="1">MENTKVLAFGEVLWDFIEGYKHFGGAPVNFAAHMVQCGREASIVTAVGTDKLGDQAVEEMIKLGVGQDFVQRNSHLTGRVMVFLEEGQPTYRIRNDVAYDYIEQSGIDTAKLNEYGAFYFGTLAQRHPVSKAAMDFIMARGSFNTIFYDVNLRRDAYTKEVIESSFGYCTIAKMNDEEVRVLSSLLYEAEMSQDDFTVRLLADYPNIDLLIITGGGQGCVIRTRSEHYKVSAKMMLVKDSVGAGDAFCAAFLNTYLRTRDARKSARIGNMVGGFVVSESGAIPIYPEKFRRKIEILSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E622</accession>
    <name>A0A654E622_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1353" mass="153868" checksum="C005F089F5AA8CF1" modified="2020-04-22" version="1">MSRNNVKKNIVFRRRIFLVLGLLSVFLLLHYFLFTYGSAISGEILKKLVLEQSQDTYELGYDEVDISLVNKRLDITNLTLLPNTEKTPDSLSHLYEVRVPHLSITLTSILGIYTRKELLFKNIAITNPAIKMIRINPGKKRETFSMETGDLYQLINSYLLKFSIDSLGVKSASVHYQPLMKDQFGILLKDIDFQVQSLMIDSTRSKNFLFTENINLILTNQHFNLADSLHYIAFDEFSLSTRSQDILFKNLRLKERADRPDAEIRGLNHYNIEFPELNFRGLNFPKAYQDNELFLDSVRIVKPTISIRKTGFSASGNDITNLVYSIFNKIKIGKLYIDDAVTSITMDIDNSNHAIRSGNSTLVIDEFILDSTNVFGQNHAFFSSLEMLSRDHSFLMPDSSHFISFKDLFVSTRDSTLRVDGISITPLKDQKDLPYWLDADIPTIDLNGLDFNRISTQGVLMLRSAKIESPEISLNINPAIQKDQKSQLGTFIKRLIATSLEIPQASLNLTRGDQKLGVDNLSINLSGIDIIPESVRDLHLLDYLRIDGLQSGRLLFSHEDFVLSVAKSEINENRKNINLSGVYFKPTTSAYPLKVSAAALTGFDLFAFTEKKEIIFKTLNLTRPQIELDVAATQKNSDFSLLQRLAFRRFSVTDGTLKVHNGPNEISHAHGVTGNLSKYKFDSLTDDYSFGIGLSIDSADHLFASWNHRLQGTKLKLSQSGTILDADFLKLNPIGSTQETSQHRMEGHQLHLEGIDFQKLINEKQLHFSKGTLKDSDLNLKISALSHSEQALSNDLLKFESFLFTNGKLQLTLPDGQLTLSAPQFDLLIEDLSLNAENQPLFARNYTFTSRNAIVSIPQLEDNIRMNAVSFQTETGYFRSSDLHLSQPHSFTAFIPDLKLTGFDINEFIQKKTINIDTFSMSSPTLTLGKMANENDPKLPDTRVRFTSISDGSFALQHPKISHQDSLYLRHFSVTVDRLDYAPSRAINLSSDLFESIAFSGESFEYTLPDSLFRVKIKNYSYDHDLKKIDLRNLRYEPIFNRGEFQNKIDYQQDWFNGTLTRMELLGFEMDSLLFKDKLQVRVINVAGLDLDTHRDKRLPREEGLYKALPQTSMRSIPMSVAIDTINIASSYVSHSEFSENGELPGIIFFRDISGSLTNFTNDPARISNRKFMIFKTKGTLMNSGDFLFQVKFDLASELDLYTASGRVGNMDLTEMNRFLENTAFVQIRDGMSKSLTFSFEGNEDYAVGEMRFYYDNLKLSVLNHETLQTKGLGVSMKSFFANTFVVNTRNPHFLFVREGDIFHERDQSKSIFNYWGKAMLSGVVSSIGATNNKKEIRQKNEEIREKLEKSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E699</accession>
    <name>A0A654E699_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="19616" checksum="4B2866C79C7ED5A8" modified="2020-04-22" version="1">MFDLKKATEVLERTPVILEHLLNDLSSQWILTNEGPGTWSPYDILGHLIHGEKTDWIPRMLIILSNDGSKTFTPFDRFAQEKASEGKSINDLLTDFKTLRAANLTTLRKQNISAEDLTKTGRHPDFGEVTLAQLLATWTVHDLNHLSQISRVMASQYSSDVGPWIQYLKILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6B9</accession>
    <name>A0A654E6B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron(III) transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_90100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="37004" checksum="B952B947AC85B6CA" modified="2020-04-22" version="1">MSILSAHSVGKNYDGRTVLQGVSFEIHKGEVCALIGRSGSGKTTLIRILAGLLAPDTGEVWLEGEKLENPDDQLVPGYEEIRLVHQDFQLKHRMTVRENIRYELLSYVSDYQHERISELLKLCRIEHLQDKDISLLSGGEKQRVAIARGMATEPDVLLLDEPFSNLDINTKAILLEEVKEIASSTDTAIFLITHDARDAMEIADRLLVLDAGQLIKTGTPENIYHAPDDTRVADLLGLYNTLTVEELQTLLPDILPPAGQHFGLWAEDLQLDPDGFAATIQKVVFGGPYNKVVLSPHSLPHLRLWAFDHTKKITPTTQVCFSIKGDRLFPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6D9</accession>
    <name>A0A654E6D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13605" checksum="8614B90DD757F6E2" modified="2020-04-22" version="1">MPTLILSSIVCEIPEESDKDEIYLMLQGKKIWPQNKKYLKIDVDEILPLGLKFNIKGPGRMKLELWEYDVTSKNDHLGNFHLDFKNLDPGNYTELLMRNEAGAQKASYYLNWEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6E1</accession>
    <name>A0A654E6E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="471" mass="53156" checksum="FEB99F5F9BDBCFD5" modified="2020-04-22" version="1">MNHEEFRKNAHAAVDWVADYLEQIEKYPVKSQVAPKDIYNQIPASPPASGEPFEALMSDLDTIIMPGITHWQHPHFHAYFPGNSSYPSVIAEILTAGIGAQCMVWETSPAAAELEERMMEWFKGMMGLPSDWHGVIQDTASTATLTALLTAREWRTDFQTNRKGTSVGKLRIYCSTETHSSADKAVKIAGLGSENLVKISVDDELAMIPSELEKAIQNDLAHGYVPCMVISAMGTTGTLAFDPTRQIGEICHKHQVWLHVDAAYAGSALVLPELDWLRDGLQLADSFVFNPHKWLFTNFDCSAYYVKDKEALIKTFEILPEYLKTKTRGQVNDYRDWGIQLGRRFRALKLWFVLRTYGVDLLRSTIRTHIDYGGWLASQIEQTPHFELLTPQKLNMVVFRYNPPGKSVEELNALNETILTQINQSGKAYVTHTKVNGLYGIRVVLGQTRLEKKHVENLWGWLVKTSDALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6P6</accession>
    <name>A0A654E6P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="PTHR17985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="28795" checksum="01AB19FD930404BB" modified="2020-04-22" version="1">MCLIVFAWDVHPKYKLIVAANRDEFYARPTAPAAFWHDEPSILGGRDLQAGGSWMTVSKQGHFAAVTNYRDLSNIRENVRSRGEIPIRFMDPALQPLNYVEDLHERSTAYNGFNVLAATPQMMTHYSNYERKANVITPGIHGLSNALLDTPWPKVELAKAKFQELIGNSFSHEELIEMMSDTSTAEDSILPDTGVSKEMEKALSAMCIRMENYGTCCSTVITIDRDGQIEFSEKSYPVGDRVEKTVNYQFKIQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7G5</accession>
    <name>A0A654E7G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15339" checksum="E7C4650AD8F7AEEF" modified="2020-04-22" version="1">MILTELQIQKLYKIASLVTIGLGLVFIAIPSATLELTERIWPAILLNIGFHLFFQVISRMPAGMNRLFQTQDSIIKTLGPLMLKIWVITAIGFTILATFFIILRAFLDSNYQILLVIPIFFAIVIAAISSWNKITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7S7</accession>
    <name>A0A654E7S7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ORF">MARINOS108_20748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="81"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="22279" checksum="8D5E4C64E9B66F13" modified="2020-04-22" version="1">MMEYPSKLVEQAVEEISKLPGIGKKTALRLALHMLKQPQAQTTNLSEALTNLRQNIKYCSTCHIIADTEECTCKTLSRDTSVICVVEDTPDVLAIRNTGQYNGLFHVLGGRISPMDGIGPDNVKIDSLVDRVKSDAAVKEVVLALSSTMEGDTTAFYIAKMLRDTPVKVSTIARGIPVGGELEYTDEITLARSISTRTLFSTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7X1</accession>
    <name>A0A654E7X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2131"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2213"/>
            <end position="2288"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2294"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2371"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2448"/>
            <end position="2519"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2525"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2602"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="2695"/>
            <end position="2751"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2757" mass="295516" checksum="9C237CDC022CAEA4" modified="2020-04-22" version="1">MVRMTNSYAKTNAIQTNRHTITNKNQISNLLIYDDEQLVHDHQKFNIKVFSFSNKSMNQVYHLFQTESGKRPGFARVLWKALSFVIVFSFGASMATAQQQLYVSTDTISAVVQSGGTAGVSFNITNSGDAPLVIDSYTERNAYGTAKSVVFTKANYANWLLPANQDRIATHVWLTRDETKSLFNAKSEVASETSSPEGTSWALGTVNEVSPGDFTTFNTMHGNDPQSLVGDTATLKIDFANGSSSKYYSIYMQQWSGGKTGGGFTYIRKEMLPFYNLTASYTGEILAGNTESVSILLSDAGLESGTHFGHVDIASNDPSQPVTTVVVKLEVLPVPQIELSESTISVSMDNAEGPIERTFTIFNNGGSTLNWSGSTSTNTQGMCANFSALSGSIEAGASAEYTITFAVCNEGTYQWPFVITSNDTGRPNVTLQLTAVVDGSPELDYTTPVFMETYTGASSTGTLILHSTGTADLHITDISSDNPVFSPTRKTLTIKPGASMSVPVKFIPKSAGSHSGQLLIVSDHEEDSLYVDLSASAVGAPVLSISPSSLAFDMGHGESTKDSLAIFNNGTSDLKWDFSVTGAVSSAGSFFEKKDHADISLSQNRDRLTPNVELARDDEGGIYNYLSAPIMYALGSAKENNSTKYKSDFRSGVNSSASDLPGQILSIYIPSEERYFDLHIDSWTCCGAGGGLSYTRYEVFKWINPEYKSNPELEVFFEKPENVNTNLPEYRDSLTENVSLVRNFYSNMGNYNGSPEIRYALGSARYLSAEDYVSYFPNAVGNASELPGKTVSIYIPAEDRYFDLDFITWSPDNYSNYTPGGYSYVRREILPTSTAAGMTDYAVINVNGNMPAGTYSGSVTVESNDPLLPSAIVPITITTTGTPDISETDQTYDFGSTVQGVAKTFEVRIRNSGSDVLEIASVVIDNSSFEISYDGISIPAGSSHKLPVTVHSSVVGPIVATLTLTTNDSEHSEYTIEVSGLILDVPVFAMNEVIFYDTLAFGSSSVQQLSIQNNGLGQMEWAVAYDVYFEKEDFALTTDASAQDRITDHVWLTRANERGLFNILEADEYTRVAETFEWGNGASTYESTEYSYFTDFWDGGDLMNNAKISMHMIPDDLYYDFHFTSWTSGEGLGGGGFAYERRAGVRWLGLGAYEGVVEAGASVDVPLYFSAVNTTAGDHEFTYRIATNDPNNPEQLITFKLHVDGEPEIEVAMDPLDFGSFPIGKTHTAESAIEINNLGGADLEITLSTDNEVFSFETSSFVIPGGTSKAIYPRFTPETETIYEGTITISSNDADEPVLNLAVSAEGFYGPEVTVSADTIAATMISGGLVKKTVTLSNTGGTNLGWSLWSGFFMKEELTDYKLEANQLHLSDKVWITRNGYNGPFNIKETSNYSYNPSSVKWALGATKDLLSTAYSADWNSLVYSLSYNFNNLPGKVVSLYMVEEGRYFDFFFTNYTNNGAMGFYYAEVGSISPNEGEILPGEAEVVELSLSAEGLDAGVHYQEFTLFHNGLAPSKKVVGKITVLGAPALSVAEESLAFGISPIGDKSYQEISITNSGSASGVISLASDHPAFTVDSESVRIKANETKTVAVAFNPPSSGDFSGLITITTDDAANPSFEVGVSGSGATAATISVVKPNLNASLFLGETITRSFAISNSGDFDLNWSLGTYGEEISFVKPDYADYKLEAFQDRVSDHLWITRQNERGIFNIALETQYNRSNYESPKGTEWLGDGSAIPGPFITVSANEYGKWRDVAYPPNEQPGRTFSMHDIKSDQYYDISWDSWTEDGNGGGFSYRRKVAFGPEYNAVSFSDTEGVIAPGKTVTVLVTYNPNSSFDGDFELPLAILSNDPANREVRTPISLSVKGIIVDRFLEDLQLNEGFGTLSIDVSDVFVDAQGDVLSLSVSNSDETAIAATILDGNLVLTETGYGHSLITLTARDATGNTATEKFEIDVNANPVVTPLEDVELTRSSEVFTLDIAANFEDPEGQELSYTMINGSDVVAEVSLTGTVLSITQLSVGTSMVSLTVTDPLGGSVTEEFAVNVSALHQEITFDTTYVKVYGDGAFELVAFASSGLEVSFVSSNEDIVTIDGTLATVVSAGSATITATQVGDDVYVAAEEVQNVLTIGKATLEVTVEDAAITYGEAEPIYTLSYTGFVNGDDLTDIATPGSGAVASALVTNAGTYTLLANEDAEDNNYAFTYTSGALTVHQASLMISADDVSKVYGDENPPLTVSYQGFVKDEDETVLNSPVVVLSAASAESSVGAYAITASGATAANYQIGYTDGLLTISSKGLTVSAIDQVKVYGESDPELTYAITAGDLVGEDVLTGALERESGENVGSYTINQGTLLAGANYELHFEEADLTIEQAVLTVTADAKTKVYGESDPELTYSISGGELIGEDVLSGALTRAAGENAGVYLISLGSVSAGVNYELQYEGAELTITKAPLTVAADAKTKVYGESDPELTYSISGGVLIGEDVLSGALARAAGENAGVYLISLGSVSAGVNYDLQYEGAELTITKAALTVAADAKTKVYGESDPELTYSISGGELIGEDVLSGALMRVAGENAGVYLISLGSISAGVNYDLQYESAELTIGKATLTVTANDVVITEGDLIPALTVTYSGFVNGDTKADLQKEPVASTTATPSSMPGAYPIVLVAEMDHNYSFVLLNGTLTIEAGEPILGVERAELIEVYPNPAVNFVMIKSSESKPLELYDAVGHLVRSGVTNHQLEIGELPAGMYLIKVEGQVFRLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E805</accession>
    <name>A0A654E805_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="170"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="30941" checksum="71F8F85D60D8FE01" modified="2020-04-22" version="1">MDKREAKFAEIVQACVDEKDFKTEAIAEYHTLIRVISGEMNIVSADMTYTFRVGDILLVPRNQLCMVIKRPKDGRPYKSIAVAFKTERLKVYYSKVDQLATQVPNKKIQTYPPHALLESYFASLEPYFELESQLPEEIAKLKIEEGIGILRSIDKAVDGLLTDFSEPGKVNLVDYMEKNYMFNMPLKKFSYLTGRSIATFNRDFRKAYHISPQKWLIQKRLELAHYLLKEDNKKPVEVYFVSGFENLSHFSYSFKKHFGYSPSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E855</accession>
    <name>A0A654E855_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024911548" evidence="4">
        <location>
            <begin position="24"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="7">
        <location>
            <begin position="60"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="216"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="6">
        <location>
            <begin position="351"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="606" mass="69203" checksum="89BBEE758FC7994C" modified="2020-04-22" version="1">MDTMIMKNVLTLILALGLCSASAQWKPAGDKIKTKWATEVDPDNVLPEYPRPIMTRANWKNLNGLWDFAMVKRNATEPQAYSEQILVPFPVESSLSGVQKMVGAENVVWYRRTFEVPAAWEGKNTLLHFGAVDWRTEVFVNDIKIGTHEGGYTPFSFDITPYLKDGVQKLTVKVWDPTDAGPQPRGKQVNKPGGIWYTPVTGIWQTVWLEPVDATSIVDIRTNPNIDDNTLSVQVATRGSSYGDLIEIKVQDGANVIKTVKTAVGQEAVITIPSPKLWSPESPFLYDLEVALIRDGVARDQVKSYFAMRKISTQRDTKGIVRLQLNNKDYFQFGPLDQGWWPDGLYTAPTEEALIYDIQKTKDFGFNMIRKHVKVEPARWYTHCDRMGVLVWQDMPNGDDQPIWQNRQYFTGTELQRTAESEAIYRKEWKEIMDYLYSYPSIVCWVPFNEGWGQFKTQEIVEWNMAYDPSRLVNPASGGNHFQVGSMLDLHNYPGPEMYLYDAQRPTVLGEYGGIGLPLKDHLWEPDRNWGYVQFKTSKEVTEKYVEYAQQLADMAKTGFSAAIYTQTTDVEVEVNGFMTYDRKVIKLDEKEVRKANQAVINAIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8T5</accession>
    <name>A0A654E8T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="400" mass="47247" checksum="5CEA39AADE46F6FB" modified="2020-04-22" version="1">MKKISTLARSLYHLNLRKIFSHFGIHKILKEHLAKEQSSVTKLSKPIKPRKTEKAIRYIHIGYPKSASTALQRGFFGRHQQLLHLGCGNDSVKGYWDDHGYIDKHVNMALEIDLRFKNDLSYDQAQVKGIFENYFLQSDSNKMVSAVGISNENICFNWHGGIDTTTKAKRLFGIFESGTKILMVVRRQTDLIRSLYKETVRFGYNGSFDDYLKYIWQYQDRNFLSDLNYDRVFNLYAHLFGRENIKVFFFEEMRENSKQFLKRISNELELDDRITHVESEYNEQLTDRELAIKLELNRRFPHSFESGFLHPFDTHRFIPYYTDFLREPRVDNEHYIDYHFRNSLCDLSKKLAPILDIDDINLSWESNYGGLIKDLLNASNQNFKTLTGDSLLEKYNYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAA3</accession>
    <name>A0A654EAA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_120391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="435" mass="47812" checksum="C90049ED99F60D58" modified="2020-04-22" version="1">MEGLIMTAQLLLGLSILVGLHELGHLLAAKAFGMRVEKYSIGFPPKIWGKKFGETEYSIGAIPLGGFVKISGMIDESLDTKTLSEEPEPWEFRAKPAWQRLIVMLGGIIVNVITGIVIFIALVYSNGEDFLSKEELNKHGIVAYDLGQQLGLQTGDRILNINGKDYETFSDLRSPNVLLGTDGFYTVDRGGKTITIPIPNDFIDKFSDKKAAFFRPRESFSVGQVREGSNADKGGLKEGDRIVAVAGVPVKYFDEFKTALDSVPGGQLNATVLRDGQELALTFDIAEDATIGFYPSMELNYSHRDFTFGEAVVNGTSQAFNVVFYNVKAFGKMFSGDVSPSKSLSGPIGIAQFFGGTWDWNNFWRITGLISMVLAFMNLLPIPALDGGHVVFLTWEIVTGRKPSDKFLENAQKVGMVLLLGLMSYAIFNDVYKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC94</accession>
    <name>A0A654EC94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system fused ATPase/permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="80"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="371"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="607" mass="67127" checksum="4AC119CC82E0436A" modified="2020-04-22" version="1">MRIFWRILGYARPLGLVVPQYLVLISLATVFSVINLTALIPLLQVLFNEVESGQMVVQPSFSWTIGYLKNLFYYHLHETVATSGRFSALYYICLLMVASVLLANLFRYLSQLILARVRVRVIQNLRNAAFLAITNSDVGFFSSRKKGDLISRVSSDVQEVEQSAVSALKIMVKEPFLIIGYFAVLFTISAELTLYTLTLVPLAGMAVSVVARRIRKWARQTQESLGQMNSTLDETITGIRIIKALAVQSYIRQRFVKEVKAYAAQSFNISKKANLASPISEVMGVAVLSVVLIIGGKMVLSPVPELSPAEFIGFLVIFSQVLVPAKAISVVFSEINRGIISASRVFDLVDSRPEIIESNDTRPILTLDRDIVFEGVSFAYEEQEVITQLNMTIPKGKIVALVGPSGGGKSTIADLLCRFYDPTHGSITVDGVDLRSLALNQWRGLIGLVSQQPLLFHDTIANNITFGRKEVSFAQIQKAAKAANADAFIEKLPQGYETIIGEMGNKLSGGERQRLTIARAILQDPPILILDEATSSLDAQSEEQVQQALFTLMKDRTTLVIAHRLSTIQHADEILVINKGRITERGTHDQLRATSGLYQQLTQLQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDL6</accession>
    <name>A0A654EDL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="322" mass="36719" checksum="EA258811DA966517" modified="2020-04-22" version="1">MKFTKTIYRKVTVRGALMVMLLTSCELVVDVDLPEFKPSLVINSVIHPDTTFTIDLSTNRSILDNNYTFPKVSGATLYLHEDGTLKGTFSESTDFPGRYTFDAYPSPGATYKIVAEKSGLPAAEAQAAIPLEKTVAEIGETSYRKSEYDGQIIRLNYTIDDPKGEDFYEVKLYVAGYYRESYYDEEKDTVILGEEQRYLSEWYYWTLGANVNEFEDTNADYIFDDELFDGQKKRITIEFDNLTHHTPDADGNDTSYYTLQIRRLAKDYYQYLITSNLQKDSGGDGFSEPVQVYSNIKNGYGIFGAYQTTLLEFALVKGERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDW1</accession>
    <name>A0A654EDW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="20361" checksum="CFD3F1047C0B4CEF" modified="2020-04-22" version="1">MTAESQMRTHMNKLLILLFLTSLNLTLNAQEIEEFFTPEHPFTHLFDTTIHETKISWRFETIHNNYIIQQFEEEGTIFRVKYRDFQLRVITPNSNQVFNKMYFQDSIGFDPEMFTMKLLGLEGYDEQTNELQFFLTITKPETDWTYPIYLYVNMDGVSRFELPTFEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE32</accession>
    <name>A0A654EE32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fib_succ_major domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011871">
        <property type="entry name" value="Fib_succ_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09603">
        <property type="entry name" value="Fib_succ_major"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02145">
        <property type="entry name" value="Fib_succ_major"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024985829" description="Fib_succ_major domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Fib_succ_major" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="18284" checksum="4A8503901B4AD98A" modified="2020-04-22" version="1">MKWIAITLLMMASGQYVTAQSGLRDLRDNGQYQTVAIDSKIWMAENLRFNSNHSHFYYLSGREVYYEGNAIASDSLCPKGWRVPTLDEWQALGNQANRIQPKPTGFLEAGRFSGFGKQAVYWTSTLDDSLNMPLAVELNPENGAVNIRPASLSLRTACRCVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEL3</accession>
    <name>A0A654EEL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="17356" checksum="7A23500A1134CDE3" modified="2020-04-22" version="1">MNLREIIDQLNEVYDGEPWFGNSISTYLQEIEPELLSKHLGTGHSIGQIISHMIAWREYVIGKLTGLDLKIEVGGENDWESRQFEPADKTELYSKFKSTQKRLNSLLSEHTDELLGKTVPNHTITFEKLLCGIIQHDIYHLGQIYLLKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSK6</accession>
    <name>A0A654DSK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS</name>
        <name evidence="9" type="ORF">MARINOS108_10068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="36968" checksum="38DFA1E0078C3069" modified="2020-04-22" version="1">MHKKSEMARILTGIQSSGKPHLGNLLGAIIPAIELSKDNKNESFFFIADLHSLTTIKDAETRRENVNAVAAAWIACGFDTEKNLFYRQSRVPAVCELAWYLNCFTPFPMLANAHSFKDKSDRLADVNAGLFTYPVLMAADILLYDANIVPVGKDQKQHLEMARDMASSFNHSYGDTFVLPEARIDDNLMTIPGTDGQKMSKSYGNILDIFLPDKKLRKSVMSIITDSTPMEEPKNPDTCNVFAIYKTIADESQIKEMRANYEGGNYGYGHAKQALFELIVDKFKEPRERFDYYLNNLPELEERLQSGEKRAAEIAQSVLSRVKVKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT61</accession>
    <name>A0A654DT61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="26070" checksum="4834C8599770CDCB" modified="2020-04-22" version="1">METKVINGYTHLKYHSISLQEPEMLRRAEEFHQYMELRRSVRDISNEPVPQELIEHIIMTASTAPSGAHKQPWTFCVVSNPELKSEIRKAAEREEYESYNGRMSERWLKDLKPIGTDWHKPFLEKAPWLIVVFKKAYAEIDGEKSNYYYVNESVGIACGMLITAIHQAGLVTLTHTPSPMNFLTQVLQRPANERPFLLLPVGYPDSDAYVPDLKRKPLNEVASFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTA7</accession>
    <name>A0A654DTA7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ppa</name>
        <name evidence="6" type="ORF">MARINOS108_10312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="20026" checksum="BB450C0F1E91CC6C" modified="2020-04-22" version="1">MMNPWHNVRIGKESPEVVNGIIEIPQGSRAKYELDKDSGLLILDRVIYSSMYYPANYGFIPRTYCDDGDPLDILVLSQIVIDPLCIVPAKVIGVMQMLDQGEKDDKIIAVAQGDMSVNHMNDIGDLPPHFVKELRNFFEDYKKLEKKTVVIEDFQDRDTAVDIVKKAVEDYTKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTP1</accession>
    <name>A0A654DTP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="37108" checksum="EE60A7DC28683017" modified="2020-04-22" version="1">MGNRNFSEEILTQLEKLEAKYDAMGQDLSAYLDGLLHSDYLTYWDYIRLDTLLSLQTPRTSFPDEKIFILYHQITELYFKLILNEQDQLIMSTETPERDTYLKRVKRMNRYFDHLIDSFDVMIDGMDPEQFLNFRMSLLPSSGFQSGQYRLVEIGSTDFHLLTCSDTRDTYGDESDVNEIYEHLYWKKGATELATGKKTLTLKQFEKKYSDTFVSRAREVRKTNLRKLYHDFFEGDQEIAEALKNLDHKANVQWPLMHYKSAVRYLQKDPEVIKATGGTNWQKYLPPRRQQVIFYPELWSAEELAQWGTREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTQ5</accession>
    <name>A0A654DTQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="Hydrolase_RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21180" checksum="E7032A4485097C31" modified="2020-04-22" version="1">MKPIKILFAHSGGGQGSVGQGSFDLVTYLKNELGNEFEMLYPIINDPEAPTYQMWKNLFINEFKKANKPTILIGHSLGASMLLKFISEEKPNFLISALYLVATPLWGKNGWDVDDFVLKDNFENELKQVNKIFLYQCKDDTIVPFKHFNFYKKAMPDATVRVLKGTDHAFANGLPELVDDIKMNIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTX7</accession>
    <name>A0A654DTX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein VF_0530</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018668">
        <property type="entry name" value="DNA-binding_VF530-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09905">
        <property type="entry name" value="VF530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="9063" checksum="53FE52DD07A135BB" modified="2020-04-22" version="1">MEQPKENQPNNPLHGIKLVTILEHLEARYGWEGLGSRIRIKCFTDNPSIKSSLTFLRKTPWARTKVEELYLRSIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUF8</accession>
    <name>A0A654DUF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="8152" checksum="7D8051604F571672" modified="2020-04-22" version="1">MISKLISYPLTAHGKDGLTGYEKKLKNSNFGLHFFKPCFRYIRHTGFASEGCFSHKQINYAPFHHRLNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN8</accession>
    <name>A0A654DUN8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_10443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="32521" checksum="C03E284EEA104DB8" modified="2020-04-22" version="1">MGCTFSLGVVEENRDRAGQILQAGIDEIVRIEGLLSEFLPDSEVSKINNHPSDLPIALDPECFHLIDRSVKISRLTHGAFDITVSPLKGLYQFRKNHFEFPSQEAVEAALTTVGYIGLILDHESHSIQKHDGMRISFAAIGKGYASDQVKALWQSMGVTSGFVNASGDLNAFGLNQWGNAWKVGVSDPENHDKILFQIPIHNASVATSGDAEQYFIHEGKRYSHTISPFTGLPLSGVSSVTVISPSAELSDALATAAYVKGVDEGMALINELPQTHCIMLDDKQEVFFSKDIQYEAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX4</accession>
    <name>A0A654DUX4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="12">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha-IPM isomerase</fullName>
            <shortName evidence="12">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">leuC</name>
        <name evidence="14" type="ORF">MARINOS108_10129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="12"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 12" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="469" mass="50899" checksum="734AC305CE4D69BD" modified="2020-04-22" version="1">MGKTLFDKVWDSHVVRKIEGGPDVFFIDRHMVHEVTSPVAFLGLKNRGSGVLYPNRTFATADHNTPTINQHLPVQDPLSANQLKALEENAKEHGISHWGLGHEKNGIVHVVGPEYGITQPGATIVCGDSHTSTHGAFGAIAFGIGTSEVEMVLATQCIMQPKPKKMRINITGKLQYGVTPKDVALFIISQLTTSGATGYFVEYAGEVFENMTMEGRMTVCNLSIEMGARGGMIAPDEKTFEYIKGREFTPQGADWDRAMEYWKTLKTDADAEFDKELTFDGSKIEPMITYGTNPGMGMGISNHIPVAESLEGGVSTYKKSLTYMGFNEGESMMGKKIDYVFVGSCTNGRIEDFRAFASLVKGRKKADHVTAWLVPGSHKVEAAIREEGLLAIIEEAGFSLREPGCSACLAMNDDKVPAGKLAVSTSNRNFEGRQGPGSRTLLASPLVAAASAVTGVVTDPRELMEEEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY7</accession>
    <name>A0A654DUY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">ctaB</name>
        <name evidence="9" type="ORF">MARINOS108_10913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="32734" checksum="8F02A5B2DF87BE50" modified="2020-04-22" version="1">MQSIELHSISFTEKVRAFYELLKFRLSFLVAFSCGFGYLLGNQGHIDWIHFGWLVFGGFLISGTSIVINQIIEKDLDKLMKRTQNRPLPTGRLSVNEAVQYALLIGALGFGILVWQTNILTVSLSFLSMVLYSFVYTPLKRVGPIAVFVGAIPGALPPLLGWVAATGSISHEALIIFGIQFIWQFPHFWAIAWVADEDYKRAGFKLLPGGGKQDLNTAINIMIYTLFLLPLGLLPTYFGLVGITSGVVATVCGALFLSQTFSLMKDYSRKSALKIMFGSFIYLPIVQIAYLLDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ7</accession>
    <name>A0A654DUZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amino acid racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="40081" checksum="71E7257DFF0407C2" modified="2020-04-22" version="1">MAYLKLKRKSLQHNYQYIASKLDAEGIEWGVVSKLLCGTKNFIQELVDLGVREIHDSRVSNLKTVKQIDSGIQTVYIKPPAKKAIPSIIKYADVSFNTELSTIRLLSEEAGRQNKLHKIIIMIEMGDLREGVLGEQLLEFYGQIFELPNITVVGLGTNLNCLYGVMPSQDKLIQLSLYKQLIEAKFNRKIEWVSGGTSVVFPLLLNRQLPKGINHFRIGEMLYFGNNLFTNKGVKGMKSDVFMLHAQIIELIEKPKVPSGDLATNPSGEQFEINEEDYGKTSYRAILDLGLLDISTDFLIPVEKGVKITGASSDMIVIDLGRTKRNYQVGDWVKFKLKYMGALGLLNSDYIDKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV44</accession>
    <name>A0A654DV44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="12">DHBP synthase</shortName>
                <ecNumber evidence="12">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="12">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ribBA</name>
        <name evidence="14" type="ORF">MARINOS108_10962</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="12"/>
    <dbReference type="EC" id="3.5.4.25" evidence="12"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="13">
        <location>
            <begin position="216"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="31"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="12">
        <location>
            <begin position="207"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="45243" checksum="AA3F135142798319" modified="2020-04-22" version="1">MSRAQLLDPIKEAIEAIRNGEIIIVVDDEDRENEGDFICAAEKVTPEIINFMSKEGRGLICVPLLEKRCEELGLDLMVGKNTAVHETPFTVSVDLIGHGTTTGISTSDRSKTIQALVHEDTKPEDLGRPGHIFPLKAKEGGVLRRTGHTEAAIDFSRLAGLHPSGVLVEILKEDGTMARLPDLRVIADKFNLKLVSIRDLIAYRMEHESLVEEEIAVDMPTEHGMFRLKAFKQKNTNETHLALYKGEWEENEPVLVRVHSSCVTGDIFGSYRCDCGNQLHSAMQMVEKAGKGVVLYMNQEGRGIGLLNKLKAYKLQEEGLDTVEANEKLGFHMDQRDYGVGAQILRKMGVTKLKLITNNPKKRIGLMGYGLEIVENVAIEVVPNIHNQKYLETKRDKMGHEILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV53</accession>
    <name>A0A654DV53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025032455" evidence="2">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="25669" checksum="296337B433B5BAE1" modified="2020-04-22" version="1">MKYLATLLIALCAISASAQQQAPKDSIPYELRKQAYIYTLAKKYNDPDVARMALYNLIATNPNSSAVLDSLALLYFDYQQYASAALVAQDAMKVDPNDLFATEVAAVAFDNLGVKTRAVNNYEKLYLANNDLGTLYKIAFLQLELKRHGEAINNADIIIASPKSDQLKLVFPIDNSRTQEISLKAATIRMKGMIEADKGNTSMARELFQKALDMEPEFAMLKEQIAALDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV55</accession>
    <name>A0A654DV55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MmcQ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="13409" checksum="8AD4E021056D5A9C" modified="2020-04-22" version="1">MNIEDLRNHCIVKPGVTEEFPFDADTLVFKVMGKMFALANVEDFVSVNLKCDPEKAIRLREEFEDVLPGYHMNKKHWNTVMAVGILSDQQIREWVDDSYDLVVSGLPAKLKAELKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV75</accession>
    <name>A0A654DV75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroF</name>
        <name evidence="2" type="ORF">MARINOS108_10257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="37261" checksum="54FCAB809CA26D1E" modified="2020-04-22" version="1">MIIQLEPNITAEQKEGLKAQIASLKYKTNDVKTQMGEYIIGIGKEKFDVRNIGHLPGIKDIHIVSDDYKLVSRKWKVNRTAIDLGDGVLIGDGHFAMMAGPCSIEGEENIEKTIQHLKENDIKIMRGGVYKPRSSPYSFRGMGIDGLKLWYKAARENGIKIVTEVMQVSQIAEMYDYVDIYQVGARNTQNFNLLDELGKVDKPVMIKRGISGTIDELLYSAEYVFAGGNERLLLCERGIRTYEKASRNTFDINAIPILKEKTHLPVIADPSHGVGIRDYVEPVALAATVAGADGVIFEIHEKPEKAFSDGQQTLDFEESAKLIRKMRALKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC0</accession>
    <name>A0A654DVC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5683 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043738">
        <property type="entry name" value="DUF5683"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18935">
        <property type="entry name" value="DUF5683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5683" evidence="2">
        <location>
            <begin position="38"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="20783" checksum="6282FCFB3A4E17CD" modified="2020-04-22" version="1">MALLLVAFSTNAQRNRADSLFLNSDLSQIETIKTVSELDPNKAALLSAVLPGLGQAYNNQYWKIPLIYGGGLIIGHYINYNNVIYNEMRNSLIAEVDSDPFTENPYKDRFQETALTRNRDAFRRNRDLLILIGAAFYLLNVVDAHVSAHLNEFDVNDNLSLKVSPSIQSTPLFSQALGFSISLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVE6</accession>
    <name>A0A654DVE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase of the HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="24122" checksum="5214E85CE2525862" modified="2020-04-22" version="1">MPKRLSEIDTIIFDLGEVIVDLDPQAVIEEFSRLTSGRGKDLRELIVGSPYLYRYETGQIDDAQFVDEINQLFDSQISLSDFEYAWNLMIKGISSGRLELMQKLMETHRVLILSNTNAMHERYFDSMVISLAGKPMKDFSHTAYYSHLIGYRKPNADIYEFIIEDQGFDPKRSLFLDDKIENIEAARGVGINAEQVQFPDQIFEILIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI7</accession>
    <name>A0A654DVI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Outer membrane transport energization protein ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="14077" checksum="265AB9C158909303" modified="2020-04-22" version="1">MNLNSKHKVEAAFSMSSMTDIIFLLLIFFMLTASFITPSGLPVNVPSSRSSEIVMQKVGVTITEDLQYYVNDRKVSINQLEAVLRDAFAGKEGVVVLHCDKSVPVEYVVQVAGIATALEARVSIATKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT8</accession>
    <name>A0A654DVT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14506" checksum="D79B3738965B9C2F" modified="2020-04-22" version="1">MLQQTRSKTSYEELLSSVIENIKKQGYENIRADLSDYESPYQLIGQTKDVNFTPDVTATKNDGKAYFEISTKVDNPNDLINKWKLLETLATMKRGKFQIFVPHGHMKFTQELVKDYNINAEVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV7</accession>
    <name>A0A654DVV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024939132" evidence="1">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="30303" checksum="CE052D1EA7C7A09F" modified="2020-04-22" version="1">MNKKVNVVLLVALSFVFTYCSNAKKEAASEKAAEKKQELEQFVEEQFEYPLPTSFEVTKMLQDANASYNSEITNDAGSVDKYVAEWQKALNLGVYGADLSYASTFDKQQESVAFLNASRRLIEELNVSTAFNKSLADRIEDNLENKDSLIMIITESFYQTYNYLNKSGDEKTSLLVVAGSVIEGLYITAQLIEASDYNASLMNVLAAQKDQVGDLTTLMEAHASDENVNKVLPFLRYVNLFYDQIGEGEEISKGQFDDVSASISEMRAKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY2</accession>
    <name>A0A654DVY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024920419" evidence="1">
        <location>
            <begin position="22"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="51"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="207"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="491"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="647"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="931" mass="103626" checksum="7CCC204C24EBAA3F" modified="2020-04-22" version="1">MKKTTHLMFLVGLFLVNALSAQETEKFDFDLSQLDIPYQKFVLSNGLTLIVHEDHKAPIAAVNVWYHVGSKNEKFGKTGFAHLFEHLMFNGSENFDDDYFQAMERIGATDLNGTTNFDRTNYFQNVPKSALDVALWMESDRMGHFKDAISQEKLDEQRGVVQNEKRQGENQPYGKFFDLVTQSCFPNGHPYNHTVIGSMEDLNAAALDDVKQWFNDYYGAANAVVVIAGDVNTEEIYQKVVDYFGDIPSGPPVTHYGSYVAKRTGEIRQVQQDRVPQSRIYMVWNVSEWGNPDAFNLDFVADALASGKNSRLYKRLVYDEQIATSVSAYNWENEIAGIFVIQANVKPGVDNMVVENAIKEELAKFLKEGPTSGELKRIKTDFFAGFTRGIERIGGFGGKSDILAMNAVYGGSPDFYKTRLQGMKEASISSVKSVANKWLSDGVYVLHINPFPDYETTGKDVDRSALPEVGPAATVAFPKLERATLSNGMKVVLAQRNTVPLIEFRMIFDAGYAADQYAKAGTANLTMDMLDEGTKARTALQINEELALLGAELNTGANLDQSYVTLSSLKNNFDQSLALFADVVLNPAFPQADFERLQKQQIVGIQNEKKSPVSMALRTLPKFLYGEDHAYGSPLTGSGYESTVSAMTREDLMKFYETWFKPNNATIVAVGDITMDDLKQKLELNFKKWKSGEVPKKNLEMVGAPNKNKIYVMDKPDALQSVIITGHLTKPYGEVSEIGVSMMNNILGGEFTSRVNMNLREDKGWAYGAFTFLYSAKGQRPFLAYAPVQTDQTAPSMKEIMGELKGYIGDNPATKEEFEKTKTNEILSLPGQWETMNAVEGSIANIVRYGLADDYYQTYAGEVQSLELSKVQKLAKEIIDPQKMTWLVVGDSKKIMAEIKALGYGEVIAIDSDGNVLQPQSQKLDVEGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW35</accession>
    <name>A0A654DW35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9209" checksum="A4E6EFFA94E1A94C" modified="2020-04-22" version="1">MVIPGDGSSLLHAPSKIVDSRAPDLKRLKIFILFWFNSIACPIAISMPQPDIAVNHLLVSTLKLGVNGSFFPIRERRLVIRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB8</accession>
    <name>A0A654DWB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetylglucosamine-6-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024829163" evidence="4">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="378"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="498" mass="57214" checksum="316CFA19C477E739" modified="2020-04-22" version="1">MKKVLSLVLLIIIASACSQKEQSYTQPDLSDRKNVVFILSDDHRYDFMGFMGKVPFLETPNMDRMATEGVHVQNAFVSTSLCSPSRASILSGQYAHNHKVVDNQSLIPEGTVFFPEYLQKEAGYQTGFIGKWHMGEHHSGQRPGFDFWASFKGQGVYYNPTINFNGTDEVHGDSAYVTDVLTNYAIDFISNRDKEKPFFLYLSHKGVHADFQPAKRHLGKYEEEPVAYPPTMFPPGHERSTVSADQYNYDDLPNWAKAQRNSWHGVDYMYHGQINFEDFYRRYCETLLSVDESIGTVLDYLESEDLLENTVVIYMGDNGFSFGEHGLIDKRQAYEESMRVPMLAMGGGIPAASRVSEVVQNVDVGPTVMDLAGLGVKAHMDGSSFKKLLYQESIPWRDTVYYEYFWERPFPQTPTVHAVRTSKYKFIRYHGVWDINELYDIENDPNEMNNLIRNDDYRKVAEELRSALFAWLSETGGESMPLKPDHGRRFDHIYRDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ7</accession>
    <name>A0A654DWQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024807173" evidence="1">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="20849" checksum="FDE8BC8E4CF66DB6" modified="2020-04-22" version="1">MSKCPFKNMKMSKIRSQIGLAVLAFSLGLLTTSCNSKAEHRPSPPASDSVQVNGVSINVEYSSPGVKKRKIWGELVPYNEIWRTGANKATFLNTSGDILINGETLPKGTYAIFTIPTDSTWTIIFNEEWDQWGSYNYNQNKDIFRLIVTPSKSDFDERMKFTLTKNALTFDWEELSYELTIDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX39</accession>
    <name>A0A654DX39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046235">
        <property type="entry name" value="DUF6268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19783">
        <property type="entry name" value="DUF6268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6268" evidence="1">
        <location>
            <begin position="54"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="32998" checksum="49EAA9BF4F123152" modified="2020-04-22" version="1">MISCFAYGQSSIDLFTLSYKHGFSQPVSGQQANAAENVALLNLKIPIVFSESTIWYNDLTYQGFVVDYDGASGVIDPTRLHGLILQTGLVRKLSETTGFQLLLAPRFMSDFQQLDWQHVQLGGIGLFEKKYSDRLLMRYGLMYNRELFGHMFVPLVFVDWKISERWSINGLLPVFGKLNYQAHPRLGMGLSLFGLITSFQLGDPVYDGDYIERKSVDLSLYGRYRLAGNLHFEARFGYALGRSYRQFNEGDEVDFRITIASFGDDRTQQNVDFSAGPILDIRLVYNLPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX92</accession>
    <name>A0A654DX92_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0316 protein MARINOS108_11565</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_11565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0316 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01515">
        <property type="entry name" value="UPF0316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044035">
        <property type="entry name" value="DUF5698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022930">
        <property type="entry name" value="UPF0316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40060">
        <property type="entry name" value="PTHR40060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18955">
        <property type="entry name" value="DUF5698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5698" evidence="9">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21470" checksum="462A01F5005FA9C7" modified="2020-04-22" version="1">MDQSTFQWVLLPLLIFLSRIMDVSINTIRIIFMLQSKKAISTFLGFFESLIWILAISQIFQNITSWPTYLAYASGFASGIFVGMIIEEKLAIGRVVVRVITRQPAMELIEYFRENSFRFSSVDATSEEGAVNIIFTVIKREALPKTIKVIKTYNPKAFYTVEGVKKVSDDEILDERSFTTRRIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF3</accession>
    <name>A0A654DXF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">groS</name>
        <name evidence="3" type="synonym">groES</name>
        <name evidence="5" type="ORF">MARINOS108_11049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="92" mass="9966" checksum="B2E81A372EBC156F" modified="2020-04-22" version="1">MSKVNFKPLADRVLVEPAAAEEKTASGIIIPDTAKEKPQRGEIVAIGTGKKDEPINVKVGDQVLYGKYSGTEISIDGKEYLIMKESDIYGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH6</accession>
    <name>A0A654DXH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="805" mass="92856" checksum="450601E38DDA218E" modified="2020-04-22" version="1">MKTFRFIFFLTITIALGVSLNTRIAGVPPLGKFLSPFHGFWQNAEEAGINYEETLDMEGLTAPVTVYYDEMRIPHIYAENETDLHRVQGYLTARDRLWQMDFFSRLVFGRLSEVLGERTLNFDRFNRRIGLKKMTEDLLETIQSDPDLLPVLNAYSDGVNAYIDQLTYAQYPLEFKLLNYEPEAWSPLKSCLAYAMLSNTLSRGESDLENTNALALFGKDMFNLLYPDQLGNLDPVIPKEKKWSFDPLKVIKPNIPYPLTTTKKTIEKPHPLNGSNNFAVSGSKSKSGHVMLANEPDLELTLPSIWYAYHLHTDDKNVMGVTVPGTPVILIGFNDSISWGVTNSPRDQVDWYSIQFRDENRSEYLYNNQWFKAEKQIEVFKIAGGATYTDTIIYVHHGPVVYDRNFFPENGKTNYAMKWIAHFPSTTINAMYEINKAKNYEDFTKAMVKFQGPPQNFMFGSTKGDIAVWLPGKFPVKWREQGKYLMDGSNPSYEWKAYIPFEHSLFAKNPERGFLSSANQHPVDTLYPYYTYDHNYEYYRGRRINDRLRILKDMIPKDMMKLQNDNFNYMASESLPMMLNYLDTGSFDTQAWNYHKTLSEWDYFNEPSLKAPSVYQLWWDILYQQIWDEIDTVSIAIDRPNKYVTIDLLKRDSSLVFADILATNARETTRDLINLTYQKAIDSLDVRMSQNNEDLSWFTFKNTTVRHLLRLDPFSVDQVRVGGYASIVNAASKGHGPSWRMVVEMDPAGTKAWGVYPGSQTGNPGSPLYGHMISRWASGEYYPLLFGPEIKNSDQVIFTQTIQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL6</accession>
    <name>A0A654DXL6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">uxuA</name>
        <name evidence="7" type="ORF">MARINOS108_11779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="43975" checksum="C40C607CB8BE1BC5" modified="2020-04-22" version="1">MHLMEQTMRWFGPKDPVSLANIRQAGCTGVVTALHQIPVGDIWPVEEIEIRKREIEAAGMTWTVIESLPVHEDIKKQSGDYKRYIENYKVSLRNVATCGLKVVTYNFMPILDWVRTNPFHILPNGSSALRFEKAAFIAFDLFLLKRPNAEKDYNEDEIRSAELRLKSMDEAEKQALYKNLLLSLPGSEEAFTPKAVLSALETYAHIDTPKLKEHLFHFLREVVPVAEEVGLKMAIHPDDPPYSVLGLPRIVSTEQDVRELINSAPSPANGLCFCTGSFGARADNDLVGMLQRLGEHVHFLHLRNTKRDAEGNFEEANHLDGDTDMVAVVKEVVHLMNRRQISLPMRPDHGHQMLDDLKKTTYPGYSAIGRLKGLAELRGVERAVVYGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM3</accession>
    <name>A0A654DXM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="22421" checksum="723ECF66E6FACA3A" modified="2020-04-22" version="1">MKPAAISMSQKNEHIERTVNTYRGKLLNFIRKFVSGSDDAEDVLQDVFYQLVVGYDRIESLDQISGWLFRVARNKATDNHRKMRPMAFSQMNLAQDSDETPLMLEDILPDTSNLPDRELLGEMIWAKIEELLAQMPRKQREVFVWHEFEQKSFKEMAEETGETINTMISRKRYAILALREGLADLYNDLIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP3</accession>
    <name>A0A654DXP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="29074" checksum="F4656B6D75B8B350" modified="2020-04-22" version="1">MKSKKQHLFIILASIFLTNAILAEMIGVKIFSAEGTFGLPPASIPLFGGSVLDFNLTAGVIIWPIVFITTDVVNEYFGKKGVKKLSYIAAGCIAYAFLVIYIITLLPPAAFWQEINSTDAEGNYFNINYAFKTIFTQGLGIIAGSLVAFLIGQLLDVYIFQKLRKYTGSKMIWLRATGSTLISQFIDSFVVLGIAFYVLAPENGRWSIPQLLSVGTINYIYKFVVAVALTPLIYAAHHFIDRYLGKELSEEMQAEAAAGSKGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY08</accession>
    <name>A0A654DY08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28614" checksum="B0828B5FFC820C52" modified="2020-04-22" version="1">MKAVIIDDEQKARRLLRLLLEENCPQITAIETAEDLPKGVALINKFQPDIVFLDIEMPAYSGIQLLEFFTPEQINFEVIFTTAYAEYAIKAFELNAIDYLLKPLRHDQLETAVQKAIQQIGQSKVSERLEELRNTLKVSNIRKIGLPVSNGVLFVELDDVIMMEADRMYTKVFTTGDGELLVSKPMKFFTDILEDVREFYRPHRSFVINLKHIKQYVNQDGGYIIMDNQKLVGISKDKKDEFFQVMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY12</accession>
    <name>A0A654DY12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="47" mass="5778" checksum="6554589BF755051C" modified="2020-04-22" version="1">MGVTHYFCYRNVRFELNLDENKNSTNSYLDFLHHYLLLTNRLQQKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY58</accession>
    <name>A0A654DY58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="4957" checksum="723310F2671B05F9" modified="2020-04-22" version="1">MASLVGFSGGLPTIKNMNDWCSVDYAITPSERGRLPVKLTLNHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY67</accession>
    <name>A0A654DY67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-galactosamine-6-phosphate deaminase AgaS</fullName>
            <ecNumber evidence="3">3.5.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">agaS</name>
        <name evidence="3" type="ORF">MARINOS108_11843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="44"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="215"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="384" mass="42478" checksum="180ABD81F80FCA0D" modified="2020-04-22" version="1">MQYLGLEIENLKSLGAIDTAREISQQPEIWLKIWDLIKNQQKALSSFIQDHQYDKIILTGAGTSAYIGESLEGTFYRNLHHNVTAIPTTHLVSHPYDYLSGNESILLISFARSGNSPESKAAVKLADNISKTCHHLIITCNMEGDLATYESKNKKYILLLPKETNDKSLAMTSSYTSMLLSGLLLSRLNELDELKAQVQLASDYAKGILTDHLNEIKEIADLPFKRAVFLGSGPLLGTATESQLKLQELTDGSIICKHESFLGFRHGPKAVVDNETLIVFILSNSTYASKYEHDLMFAMDKGKKALAMVAIAERIDFDIPVDYKISHTQNGLHLEEDFMTLPGVVPGQLLGFFKSLSLGLMPDQPSTSGAISRVVQGVNIYDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB1</accession>
    <name>A0A654DYB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="907"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="787"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="967" mass="110690" checksum="51977F0F4432F3C8" modified="2020-04-22" version="1">MIMNRIQPRIWIAIFTLHTGIAHGFQEQPFAKNPSVRGAPEIIHFGLDDFQSDPMMMAMCEDSSGVKYFGNQDGLLIFDGETWARLELPNKSLVKSLYYGSDHKVYLGGFNEFGTVERDKFGQYQYSSMVDMAKVDHLNLDFVYDIHEVQGHIIFRSMSKLIAIKGQKALTIPTSGFYSSAVVDDRLYMANWEDGIKEFDLHTMNFDLLIPKPLYQWNPIVSITAGNSAETLSIFTRDGQIYSYHLESKHFLLVRNLFNKTSTNQVTGAVRTKDGDYYIGTLADQLIMLTANGKTIPLNKPIIGLQDESVNNLYESKNGNLWVLLENGIDCINLSSPVSTVFNKASVFDVQLFQGIWYIATNQGVWASVQGLTGGPFKHMQFEPIAGLDGQAWSLTSIENQLLCGHEKGLFVIKGKDIKQIPASDGVWKVIPIQEKPGHYLVCTYYATYLMSVNSTGDFQIDNVISGFSESSRDILQSEPGVFWVCHGFKGVFRIKINPDYQSVVSVEHFEEAGLPSPYKVNVFSWKGEPVFTTSKGLYSFNDSLDVFQPHSLLNDILDPNIETRKIMETKDRTWYIHNDEVGYFNHEDNPVLQSEAFLQTRGTFNKHMESITLLDNGVLIGTKKGLFAFDLSSRTGSPVPHSVRISQLSYQNGNSRILLPLDNPLEILASQTQNLRFEYTVPQMDMLNDVRYSYQLSGADQVWSDWEDKPWKEYNSLDPGTYEFSVRAKSKLGESFLTAQHTLIVRPPWHQTTLAFVCYFILGLALIFLCVKVISKLLEEQRQRAILEAEKQNKILRLELDRMQLAQEKNQFESTKTSLEEDLLLKSKELANYATLLSRKQELMIELREELTDLENNTRNEKTRQDLKSLIRKIKTRLNNDDYIKVFEANFERVHHEFFNELKERYPDLTSKELRLCALVKMNLTNKEIAPIMNISIRGIETARYRLRKRLSIHDDMVEFLEKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW9</accession>
    <name>A0A654DYW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025046288" evidence="2">
        <location>
            <begin position="24"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="40345" checksum="0147856BD136F419" modified="2020-04-22" version="1">MSTSSMKHILFFLLVTIMASQWAVGQPYTNSVPSGDTWYQIGTRGNRLVKIYATGDFAVHEMVVYIVSGNYNTAEFTIVSEYNYNHKQIKLEWGYVGSGANRYLVLKSTPTPNATYANGFTITDVSDPTTDFNLTPVSDVSSIVPISPSNVVYNSEHLQRVGIGTLEPMSKLHVKGATIFEDPIRFHNGTANKGLVWGNDSWANYYSRIDDYGGQLRIMTDDKLLFTDINSGDGAPTSTAVFINTNDKTLGVNTDLIPSGYRLAVAGKAIMEEIKVEAAPWPDYVFSEGYELPDLGATADFIKENKHLPGIPSATEVAEQGILLGEMNAKLLEKIEELTLHLIELERQNKKLNERLTNLENKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ64</accession>
    <name>A0A654DZ64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <shortName evidence="5">HK</shortName>
            <shortName evidence="5">HSK</shortName>
            <ecNumber evidence="5">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">thrB</name>
        <name evidence="8" type="ORF">MARINOS108_12011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="200"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="33087" checksum="593E38A8D1B13D2C" modified="2020-04-22" version="1">MESIQVFAPASVANVGPGYDTFGFAIEQLGDVITLTKRNDHKLKVLKAEGADLPTDPKNNVATVAIQSLLDYLESDQGMDVHIKKIFKPGSGLGSSASSASGAVFAANHLLGNPLKLEKLLDFALEGEALASKSYHADNVAPSLLGGFQVVRSYEPLELFRIPTPAALRVLIIFPDVEIKTSEAKGLIPKELSVKDAREQWGNVGALIHAMHSEDYSLLSHAVRDRIAEPVRKQLIPEYGKVKQTTLDFGAVGFNISGSGPSMFAFFKSSEAAKACMVKIEKMYQKVNLPVMLHLTKINPNGCQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ97</accession>
    <name>A0A654DZ97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="377"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="616"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="731" mass="83051" checksum="36268CE6E7C3641F" modified="2020-04-22" version="1">MYYTDLTDAKRVLQFLKRANQQDIDLHIGLGLASRALELSMKLDDTGLMARSLYKLSELHQALGEIDQSIHYIREAIGLYQVLGEEELIARSKFQLAEIHYKSENYHLSLIYLLDCLDIYNRTKDYYNLAGVQKFLGGIYEYFGDERNAIMAYERSAQAARRIGARDLESDAYNPLSGIYLNQNDTEKAEQLIERSFQMKQELGDKRGLAFALYGKAKVYVKKGQSNRAKEAYQEAIRLHREIGELLGLGMCYHKLGVMYYEEGDLDKAIEALKGALNFAGLYNLVVIKSKCNNLLYRIFKERGDFENALGYIEDYVTEKEVLIGAQTQKVIHSYDAITTMERLQKDAENQREKAEIMDKKNKAEQSSKMKQDFLSTMSHEIRTPLNAVTTITSLLQESAREDQVSLLSSLSFSSNNLLRIINDILDFNKLDVGKLRLQPSTVAFRKLMENIRLTYSNMAIEKGISLKMHISEQVSDFYKVDETRITQILGNLVSNAIKFTEKGSVSLNIEYGETKNNKDLLRFSVVDTGIGIEEDFIHEVFDSFSQPQFHKSKKYGGSGLGLAIVKKLIELHGSNIHVESQVGHGATFYFTLYLEKAEPRRLKTETRRKKLNPKSILLAEDNMINAMVSLKLLGNWGMESVHARNGEEAVKLAESQVFDCILMDIHMPSMDGIEASQRIRNTNNPNVNTPIYALTADVMVGFGDESSQFFNGFLLKPIEQEKLYAVLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD2</accession>
    <name>A0A654DZD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="39013" checksum="89CF8BF3207D2561" modified="2020-04-22" version="1">MARITIKEIAKKAGVSAGTVDRVLHNRGEVAEATRDLVLKIAKEGNYSTNVFARNLKLNKVYNLAVILPKDNEYWKNQSEGIEEAAEEYASLGMQLSFYTFDRQDKDSFLTQSNIALNSSPDGVILAPLLQREATQICESLQQADIPFIFVDSNLDNIKPLAFIGQDSRQSGFLAAKLLNLGYASGQKAIVIKYTDFDSLNKTLDERIEGFRKYYQQENFSPELIHEITLEKDFVGLPPGIESLLGNQEPVHFFVPNSRVHQIAKSAENVIPRHLSRIIGYDLVRENIVYLNKGLIDFVIYQNPKVQGNLAVQAFYKHLILKTEVPPTHYMQLDIITKENLMYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD5</accession>
    <name>A0A654DZD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009722">
        <property type="entry name" value="SdiA-regulated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06977">
        <property type="entry name" value="SdiA-regulated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="312" mass="35381" checksum="613D57B56EF748A2" modified="2020-04-22" version="1">MSINNNSRGLFILFLVINLFLFLTLAQSSCSTASFREQADSLFLITDDVNVYYNLKIPDDKYFLPYSLSEISGITHLNDTHLLCVEDEGGKVYEYNLLKRKITNTIAFSNPGDFEGIELVGDTIYVLESDGDIYEFTYTKHSTTRATKHENQLSRKNDTEGLGYNPYTGRLMIACKEDEDIEGTNAKGKAVYEFDLHTKRLVTPPLFEISREKMDDFFEAHRDFEYDKNRIKFEPSGIAYNPLDGHFYLLASVGKLLVVLDRNGTIKATYPIAPRVLSQPEGISFSSQGVLYISSEGEGDKGYILKFSPHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF6</accession>
    <name>A0A654DZF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlgD_ig" evidence="1">
        <location>
            <begin position="863"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="936" mass="102739" checksum="2E3D1E327BEC1B0B" modified="2020-04-22" version="1">MNRVTGFLACLIFFSIIREPKPLPDYSLVLDQQPSAIGTTEDPQARANYENRLLVDPSTGQIPKDIRDRELRFAELLLSRQHRAGHHQRMAAQNYELAGPFNVGGRTRAISLDIRNENTILAGGVSGGIWKTTNGGTDWKRTSDPALRNSVTALNQDLRPGKQDIWYAGTGELLGNSARSTAAPYRGAGLFKSTDGGETWEALPGTIDNATPNQFSSQFQYIWAIETNQLNLTQDEVLVAAYGAILKSSDGGQTWGVALGQKLFDLPENTDLNESDAPFYTSLRKTPSGHFFAAMSSASSSNKLSPSAGFYFSATGDQWQQITPPGLAAYHERTVIGFAADESSVYFLTQSEEASLWKLNVTNIQNGILSGSWTNLTSNIPASGGEYGDFESQGGYNMLIEVHPQNPNLVFIGGTNLYRSTDGFSSTKNIKWIGGYSPENDASVYPGHYPDQHALLFYPSDEKRMISANDGGIRLTTNVLADSVSWKSLNNGYLTSQFYTIAQRLDKDTDEILGGMQDNGTYMRDALGENPSWNRILGGDGGYCAIAPNRDFVYVSFQNSQIYRLSLSSTFQLKSFARVDPIGGGEREGQGYLFINPFILDPTNASRMFLTGGDVIWRNENLLQVPGGNQKKTSVNWSEIKDTEQASGVYTAIDKARDQDILYAGIYSQSPTIVKVENASDPTRESVTFMSPTIFPENGHIACVTVNPENADHLIVVFSNYGIPSIFMTVDGGVSFSDISGNLEENPDGSGSGPSVRWAEIVPTTSGISVFVGTSTGLYSTTATNGGQTIWIKESEDKIGNAVITMIDYRDIDGRLVIATHGNGTFQSFLEDTRPFTNQHSPGEQLTSLQNYPNPFTNETMIRYSLPENGEVKIDLYDASGRFIRNLLWGPQYAGENRTIWDGTNNSGTRLKSGIYTYVLQFQGQQISKRMIYLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP2</accession>
    <name>A0A654DZP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="16389" checksum="681683BE56BF13C7" modified="2020-04-22" version="1">MAKHHRQTKQSNVVGRHGQGVSYEHQESIDDSLLPEATELASLKELDPDVMSWVKERTAKEQDARLDFNDRKMGLLERGQRMSYRVDLLAILASFTITMSGMVFSYFLVQANQIITGSVFAGATILFAANSFLNFRKKNSGNTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP4</accession>
    <name>A0A654DZP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="5">
        <location>
            <begin position="153"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="353"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="569" mass="64531" checksum="7E7FCB43695E987F" modified="2020-04-22" version="1">MADWLFYILKVSAFQAVLVLFYLLFLRGLTFYQFNRIFLLGILVIGFALPFVQIESAPVVQANQELVTMIGTRISQSSAAMTEGVIVPGFQVSWIWLLSSLYALGVLLLFQRYFSNFYKIRKFKYGYQLIAKIGAIEVFRTPFAQPFSFFRSVFIPEKVEHTQELNMVMAHELQHVNFGHSYDRMLADFIVVLFWFNPFIYLLRKSLIEVHEYQVDAAVTADSGVKIPYQMSLVSLAGGGFSGPVSFFNFSTIKKRIQMMNRNKSNKISLMSLALLAPVIGGMVMLFSFEMKTPEMIFIQDNPSPALEELVLPVEGAWVETPSIFPLGVKDEKVRVTSNFGYRTDPFDEAKKFHRGMDISAAEGTPVIATADGKVTLVDDQPDGYGKHIVIAHDEVYQTKYAQLSSMDVKEGETVKRGQLIGRVGSSGRSTAPHLHYEVYKEGKAVNPVNYIADYQFAIQKQQQAEEKQRMAELKRQEAEEKQKVAELKRQEAEEQQKVAEVNQREAEEVQRAAMQEQELAEVLRAQAEAIQRAVEQPEAAAKPKVEETPKVKEKSKAKTKSKEKDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR4</accession>
    <name>A0A654DZR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 15" type="primary">gpsA</name>
        <name evidence="15" type="ORF">MARINOS108_120075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="351" mass="38273" checksum="310BA2D269A3A6BE" modified="2020-04-22" version="1">MGSKNTSEKPIGVIGAGSFGTAVSNILAEKNQRVILYARTAEKAALLNSTRESSGHKLHDHIEVTNDLEYIGTSCDVIFPVVPSANFRAMMKELAPFLRPYHILIHGTKGFDLNVDLKKIDAQNPLSREHVRTMSEVIKEESSVVRIGCLAGPNLAREISEKKPAATVVASHFDEVIRVGQNLLKNDRFLIYGSNDLIGIELCGILKNIIAVGAGTIAGLELGENAKALFISRGLVEMVHIGKALGGNAEAFLGLAGVGDLVATSSSHLSRNFTVGNRLAKGETIDQIIESMEEVAEGVKTIRIINELSQTYKVRCPITETLYRIINQEMTVGDAHKYLMKFPFRAEIDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU2</accession>
    <name>A0A654DZU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018717">
        <property type="entry name" value="DUF2241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10000">
        <property type="entry name" value="ACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ACT_7" evidence="2">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="14961" checksum="E29FD81F888AC284" modified="2020-04-22" version="1">MTGETNLTTLIRSMMPELQPGEYVFASVTNLSGISREDTICEFREAEGTTVVLERKRADALGISYDFVASWITLKVHSSLAAVGLTAVFATALAKSNISCNVMAGYYHDHIFVDAGDAQRAVDVLRGLSAEADPLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E028</accession>
    <name>A0A654E028_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="34364" checksum="BFD8BBE8082402CB" modified="2020-04-22" version="1">MNPTPHQIDSYLRNELSSSELSAFEAEMSNNPELMDQVRFEQTVVEGISQYRKAELKARLDAIEIGSGWMGIGQLGSSALVKSVGGVLVASLVGVSAYFVFTAEENITSPEIIESIEITSPKQSESYQFEFPELSVQKVSSVVSESSPNVAEKSSATSDEKVKALPTVQKSVASVDEETEFVPVVDLPDLGELSEEKGLKIEDANLPEMNEMDVVSSKGESPISVETIQRNSESIKYKYFDGKLFLYGDFKSTPYEIIEINRPSERKLYLFYDQEYYSIIVSDKVQELSPITNHQLLQELEIVRNNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E029</accession>
    <name>A0A654E029_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="102" mass="10960" checksum="A73138D6FB3B9B7A" modified="2020-04-22" version="1">MIISQPFSTKSSRFSILIKPLLAIGALHDLLGSLHGPLEVLHGCLVPLHSHLGTLHGRLKPLHGYLGTLHGRLGTLHGFLGTLHGLLQTLHGCLEPLQFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E037</accession>
    <name>A0A654E037_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative AlkP superfamily pyrophosphatase or phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="419" mass="46895" checksum="8EB6DF4C973F7CCA" modified="2020-04-22" version="1">MKKSVLFFVSILGTILLSRGQGVSYTDAQAQQQVIDRDNSDWAMQQGYVVLVGIDGFRYDYAQKYGAKHIQKLGQKGVKSERLLPSFPTKTFPNHYTIVTGLLPGNHGLVGNSFYSRAKQAWYHVWDREAVREVSWYAGVPLWVLAEEQGMLSASFFWVGAESPIHGVKPTYNYAYDGSMPNEHRLRQVLDWLRLPDAKRPHMIAAYFSLVDDAGHKYGPDHPRTGEAVLKVDSLIGNFMDSLDQLDLPVHVVLVSDHGMSAISHGIVLPDVADLDDAQVSYSFPPMVYQPDSAKRLKLYDQLLRVPNMDVYTRENIPDFLSFSNDDRIGDFILMTDAPTIILEKPRPVSGGTHGFDPYRNVNMGAIFYAAGPKLKSGLEVPPVENIHIYPFIAELLGLTISEPIDGDLNALQILLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E041</accession>
    <name>A0A654E041_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="22648" checksum="49EF16B10CBB5BB9" modified="2020-04-22" version="1">MSTDLATWSDAELIEKLKEGNASRFFQELYERYYKKVLDKCYSFVKNRETARELAEDVFSKTFEKIGSFKQKSSFSSWLYSITYNHCIDYLREKKKLHYPEWNKENEIPEIIDESDEALSEITYENLLLIMEEIHPEEKALLLMKYQHDLSIREISTSLRISENAAKMRLKRARTRVVFLYTQKYLKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E068</accession>
    <name>A0A654E068_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024888979" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="28733" checksum="16A24DD1690E4180" modified="2020-04-22" version="1">MKTLLTILFISFFNFLNAQDVPTLKPTIGKMLDFGPTIQKEWALRDKALEDLNEGNRSWEELTSEEQATFEKYGEVYENMWDIVGGGCSWYCGGGLDTQTASSELSAQGTNTYIANNAHDLSYETAWVEGVPGYGIGEYLEYHVKPENPRITDIIIVNGYVKSDNAWKNNSRVKTLKMYIDNKPYAVLELADTKAEQHFKVDPIGYNDRHNFEQLKKKSSFTMKFEISEVYPGAKWDDTAITEIYFNGIDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C2</accession>
    <name>A0A654E0C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF418 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="258"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="49509" checksum="59C0CC8D7EC30A95" modified="2020-04-22" version="1">MSQPLPSPAPTSSAERIGTLDFLRGIAILGILVMNIESFSYPDPWSPFKNGFSGPEDHTVRFWVYFLAQGKFFSMFTLLFGVGFYVFLERLEAKGLGLKALDIYARRLLWLFVIGVIHAYMIWDGDVLYHYAVCGFLIFPFRSFTIRQLLMVLCIPIAILLFNDYQRTLRTQNSFLSYEKAIEKSEDERTADEQRTIDQWVRKTTEGKSEMKVDETPRQTLLESWVANAEHTRVHKGAILYQGILFRTLIMMILGILLYKSGIFKDYRSARYYWPLTITILILALVINYHRYQHWTYDYYHPVTNIWEGWLFTFPKETLGLAYILVFNGLYQKWLKNSKFKIISTAGKMALTNYIFQSILCGLIFYGYGLGKYNEYSRFELLLIVVMIWVIQLGLSWWWMKRFSQGPLERAWRKLTYKAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G4</accession>
    <name>A0A654E0G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="24671" checksum="8B30E106FC64AAA4" modified="2020-04-22" version="1">MPPASHVYIHEDISSIQELYSDLTEDLSATPLVIDFLTASAEKLLHAHRTNLHAAFVEIRNGLPQFAGKSISEIFNYAFTMLDARTTVARLHGFEDWEEVERHSENSFNLEFEKAIDLLLGGEVEHLSQLLSTHPALIKARSPFGHQATLLIYCGSNGVEMRRQVVPDNLPEMVNLLLAEGAEKHAKARVYGGQFTTYQLAESSAHPHDAGIMDKLLRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H9</accession>
    <name>A0A654E0H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17799" checksum="ED67607C60E0BB73" modified="2020-04-22" version="1">MVKNLYLLRHGQAEYGFQGSDFDRSLTVNGVIQLRSLGQAMKLKSFYPDKVYCSTANRTQQTAEIFTEELDYTLPVHYMEEIYEASVRTLFELITKQDEADSVILIIGHNPGISYLYDYLTSANFGDMTPGELVRIEFEDLAWSEISKGVGFKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R0</accession>
    <name>A0A654E0R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="15420" checksum="5383237E070EE04C" modified="2020-04-22" version="1">MDFKDFSKRFADKIGGEYQEYDDNHSIFVIPLKDDRFQTVIARLVDHEKYNRKTVQVTSKVCSVDHPIDYPAVLEASKDFVHTNFIVEDGFLKVDTSIFLDHTDENLIEEMITEVAYTADEWEFKITGQDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R5</accession>
    <name>A0A654E0R5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmD</name>
        <name evidence="7" type="ORF">MARINOS108_120479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="6749" checksum="AB8B77CB0A06DE03" modified="2020-04-22" version="1">MAKVIITQTRSIVKRPQRQKRTIQALGLGKINRSVEKELTPQISGMINKVQHLIEVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E186</accession>
    <name>A0A654E186_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillinase repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14463" checksum="C70E73844B8D92D5" modified="2020-04-22" version="1">MKALTKAEEQVMKYLWKLGRGYLKDIVAQYSDPAPAYTTVSTVVNVLVKKEFIGFETHGKSKEYYPLISKADYAKESMQGMMHTFFNDSPKQFASFFTQESELSIEELKELQDMIAAEIKKQEKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E188</accession>
    <name>A0A654E188_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_140173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="256" mass="29728" checksum="91C593E2040C2F33" modified="2020-04-22" version="1">MRKLMKDQEVGLDPYFRYRGKNQTRVEAFTDAAFALGITLIVLSTSAPNTFEELWLSMRDVVPFGLCVILVMVIWYQHYIFFLRYGLQDSRIITLNTFLIFLILIYVYPLKFLFKILFDLYVGLFTSDREIFQHLFTSVIKLEDTPTLMMLYGLGAACIFFTISLMYRHALKISSELELDEYEIHETKAALRTNLLMGIIPLLSALIALSGLFGMHNFTVSGFIYMLYPPVMITHGKMAQKRRDQLLKKLNLQPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E196</accession>
    <name>A0A654E196_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein YphA (DoxX/SURF4 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="362" mass="41257" checksum="6EFE099BC3C4F0A0" modified="2020-04-22" version="1">MKILFDIARYLVGALFIFSGVIKVNDPIGTAIKLQEYFEVFAYDFAPFFEWFVPAALFLAVLLSVLEVVLGIALIIGFKMPRTSWALLLMIVFFTFLTFYSAYFNKVTDCGCFGDAIKLTPWQSFYKDLILLVLIIAIFKNRHQYGSWFSEKFGFFKVVGSAIVFTLLAYYAIAHLPFLDFRAYSVGNHLPSLMEPSEELRYQYVMEKDGKEEILDTYPTDKAYTFKAMELINPEAQPKITDLSMWNDEGEFTEELLRGNKLLIIIYDATKASRTNIEAIRTLSSQTQNADVWVLTASGYEEFEAFRHDVQLAAPYFYADATVLKTMIRSNPGVMLLSNGTVVGKWHHNDTPDVSEINGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C2</accession>
    <name>A0A654E1C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="517" mass="58005" checksum="60497D91D1B63162" modified="2020-04-22" version="1">MKAIRYTGLILFLFSFGLFLSLFFMSSYQLSEGTFAEKVKPEHQALLKASFEPLFGQAYHFSIPFVNAINGAIETVNDENRALQKWDEIIYDDYAGALTRASTSGLITTHTSLLLALIFGIGTLGALMFILPQVTLAGPAGIKNNGIFHHALNNRGWMGVLIGSLLILFYIALYFYPAYVTNWIILVDPIQKLINPGGESSQWFLYGFLYSFAVLVMGIRMIIKYRHSKYQIVRTCSVMFFQLAIAFLLPEILVRLNQPYFDFKNMWPLDYDFFDAWHINTLTSAGGLGIFMFAWGITLFVIGVPVFVFFFGKRWYCSWVCGCGGLAETAGDSFRQLSDKSLKAWKIERWLVHGVLVFAVIMTIGVLYTFMTGSNTLLGLDTYTFLRKPYGFAIGSIFSGVIGTGFYPLMGNRVWCRFGCPLAAYLGLVQRFKSKFRITTNGGQCISCGNCSTYCEMGIDVRWYAQRGQNIVRSSCVGCGVCSSVCPRGVLNLENRDEDGRFNEPILIGNNSLKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P7</accession>
    <name>A0A654E1P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="357" mass="41058" checksum="11778DFF80A2F0DA" modified="2020-04-22" version="1">MKYIFIIQGEGRGHMTQALSLAKILRQNGHEITRVIVGKSERRSIPQFFTDKIGTEVVPLESPNFVTDKQQKSVKPFRTIVYSLLKAPIYKKSMDRMDEIVREDEPDVIVNFYDFLGGLYNFSRRPKALFICIAHQYLISHPEFDFPPKRKLDKLSLQMGNKITSLGANKILALSFQPFQDVPKKKLYVVPPLLRDEVKEEQVTSGDHFLVYMVNPGYSAEVEKFHQTYPEQALHCFWDKKEIPEEHQIDATLTYHQLNDEKFISKMASAKGYVTTAGFESVCEAMYMGKPVLMVPVQGHYEQACNAVDAMKAGAGTFSESFNIEKLYQYLPNHVDISRPFQQWADQATEMFPKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H0</accession>
    <name>A0A654E2H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="19955" checksum="3744399E3F94BFA3" modified="2020-04-22" version="1">MTALEFSYKVDQLTSSLKPFALKLTRDMEDANDLLQETILKAFTNRDKFAEGTNLKAWMYTIMKNTFITNYQRMMRRNTFIDTTQNLHYINSTSSTIQNNAYTDFAMRDINGAIDKLQDSYKVPFMMHFRGFKYHEIADKLNIPIGTVKNRIHIARKELKTKLKVYGNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H1</accession>
    <name>A0A654E2H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024895455" evidence="2">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="14453" checksum="9A4C6A45D8C7CC9E" modified="2020-04-22" version="1">MKTNKLLIATLALFAVNVPAYSMDGMSSSSFNITLGLLELPFLIMAVVFSFLNAKNLKGGKFGTGMTYLAWGFLVMAVGHLHMQIDYHFGFNLFNTLLGESGGLIAWFIALILTWGLSGWGFYQIWKVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I6</accession>
    <name>A0A654E2I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="36886" checksum="7E5FEEE8039C7BA9" modified="2020-04-22" version="1">MISTLKKILLPLSVLVILGFVLFMINQISGVYLMLKEINQLTANVVLVVLSAVAIGLAGWPVLLFLKLPRAISLPKNQDELPRYRQHLLMRLRRNEILRAQGIQPQKVEDLAESILVLNQSANRVIQQTATAVFLTTSVSQNGKLDALTILATQSRMVWKIAHIYYQRPSLRELIYLYANVAGSSFLASEIEDLDVSQQVEPVISSFLKNSAGKSIPVIGPTANIILDSLLEGSTNAFLTLRVGNIAQKYCACNEVVDKKAIRKSAFMESASQLKGIVMKSSGQIMSGLLKATRKAGVDTLKSGWEGIKNTGVKVAEGISEAGQKINPFRKKEPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K7</accession>
    <name>A0A654E2K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="25783" checksum="0ADB4198BE121BC9" modified="2020-04-22" version="1">MITVTNIRKSFGNLQVLKNLNFEISKGGIVAILGPNGSGKTTFLKILLGMVIPDGGHIFYQQKDIAGSHAYRKHIGYLPQIARFPDNLKVREILEMIADIRNEPASPEPLIELFGMEKFMEKKLGDLSGGTRQKVNIVLTFMFDSPVIILDEPTAGLDPVSLIRLKELINKEKSKGKLILITSHIMSLVEELADEVVFLLEGNIYFKGTVTDLKSKTDSVDLEHAIARILEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E325</accession>
    <name>A0A654E325_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="20608" checksum="A10D8929AB34F142" modified="2020-04-22" version="1">MIRKIAIIGPESTGKSELCQHLARIYDTEWVPEYARFYLDRLEGEYQKEDLLHIAQGQMAWEDDKAEQASGYLFCDTNLIVMKVWSEHKYGEADPWILEELERRQYDFYLLGNIDLIWRPDPQREHPKLRKHFFDVYETYLKEHDLPYAIVSGIEDLRVKCAQDLIEDFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E362</accession>
    <name>A0A654E362_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
            <ecNumber evidence="2">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folP</name>
        <name evidence="2" type="ORF">MARINOS108_20014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="31806" checksum="8D7777EA0A66E550" modified="2020-04-22" version="1">MLTFVRDKSNTLTAQKSINIKGTLLDLSVPKVMGILNVTPDSFYGGSRQQTMADLLHSADKMLNEGATFLDIGGYSTRPGAEDIDIKDEIKRVLEPIRQVASRFPEAIISIDTFRSEVASEAIGAGAHIVNDISAGMLDDRMLERVGRMGVPYIAMHMRGTPQNMKQKTGYEDLLGEMTHYFSERILAAKTAGIKDVIIDPGFGFAKTVEQNFYLLNRVEYLKHLGHPLLIGVSRKSMVYKTLNIEAEAALNGTTVLNTVALLKGTSILRVHDVKEAVEAVKLVNQIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D5</accession>
    <name>A0A654E3D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="161"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="470" mass="50286" checksum="E15B36260091543D" modified="2020-04-22" version="1">MTDFGFLSLLPPILAIFLAIRTKQVIVSLVFGLLLGYVIIAGGNVFEGILSTADHLVQVFESAGNTRTVLFTLLIGALIQLIRYSGGINGFVGRIQKSILKSKNPKSKLQVAAGLTGFFIFIESNISILTVGTVFQSLFDKFNISRQKLAYLADSSSAPSCILFPLNAWGAYIIGLLSVYEGVAPFKTLLYSIPFNFYPILTLALVFFLAATNKSYGPMKRFEQNTVDTPSNQEELPEGKARNMLLPLGIMIISMPLFLIYTGWSAETSGSFGTKTWDAIANASGSAAVLYAVISAVVFAGVFYGFQKKISLGNFIEESMTGMKEMLSMAILMVLAFAIGTLCKELGTGVYVASVTSSWLSPSLAPAIIFLTSCFIAFSTGTSWGTFAIMISIAVPLAQAIDLNIYLAVAAVLGGGVFGDHCSPISDTTLISSMASGSDHIEHVQTQLPYALFTGGLSVVMYLIIGFLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E7</accession>
    <name>A0A654E3E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019883">
        <property type="entry name" value="Lactoylglutathione_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03645">
        <property type="entry name" value="glyox_marine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19609" checksum="A6D14D92568B8EC8" modified="2020-04-22" version="1">MNDIKYPKSFSHIGITVPDIRKAVDFYHNVMGWYVIMPPSTVKKERETAIGQMCIDVFGENWEEFEIAHLSTSDGIGIELFSFPHGIKEAPEFNPFNTGLFHFCVQDPDIENLTKRIVESGGKQRMPIREYYPNEKPYKMVYVEDPFGIVFEIYTHSYELTYSSGAYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I8</accession>
    <name>A0A654E3I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="363"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="210"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="582" mass="66245" checksum="39A16961027E04CC" modified="2020-04-22" version="1">MLRVLLAFFFILIFWSGHAQEYPLSKSDSGIVFKSLEKYEALIAKDDFRGASGALNDVAFVYWNNNHYAEAATYYEKSLVLNERVSNENGIAMINNNLGMLYADIGRYEESLAAFTKTLAARRASNEPAGVISALVNISVVLNNLHKYSESIKHLSEAIDIARELYDKHQMRSVYGMLSETYEKMGEVEKSLQYFELYKSFHEDIQRAEIKGMNRELAEERLEKQVLEADKAKKEIELLKQQLEIYEKEAQLQAKDSINQSLYSNLSRKEVEIELLERDKELTAMAAAAREAENKKLQSQKAYLRNSLIITILAVVVIGILILINIFRSRKYNKELLLKNESIEVQRRELEIANETKDRIFSIISHDLRSPIGSLEGFFFYVIDDFEMSDDLRKALNSVQNQLTNSASLVDNLLNWSRSQIKKEEPHIEEVEVAKLVEETFRLLRHQATTKQIELISNLSPTDRLISDTQMVNIVVRNLVQNAIKFTPKGGTVVVDFETDQKGDCLKIFDNGIGMDEQKIASLFNISTNHSTLGTEHEMGSGLGLILCKELIEKVGGLIEVSSQPGNGTEFSLRFTKTEYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M3</accession>
    <name>A0A654E3M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="393" mass="43423" checksum="0AA6F80187175A4A" modified="2020-04-22" version="1">MSVRRVRYLIFLRDVLILSVTSFGGPTAHLALILDMMVTKRGYLSETDLMELYALCQILPGPTSTQTITAIGFKIGGPSLAYLTLLIWALPALTIMICMGIMVNVFQDMDISLSFLKFIQPIAVGIVAYSAYRISSSVVSSRTGFFLMIISTMASYIFRTPWAFPIMLLIGGSITAFKFKQQPLEEKSTIKINWSNFILWISVLVFAAVLGGVTQYLPIRLFENFYRNGSLIFGGGQVLVPLLYTEFVEFKGWLTSEEFLSGYGFVQALPGPVFSFSAYVGAVSMHNTDIPQQILGGVMAAAGVFLPGTFFIFFVSRFWEDLKKYRMVKASLEGINAVSSGMVIAAAFFLFEPIAPTTLNYSLMLGTMCLMFFTKVPTPVIILVGLITGIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U5</accession>
    <name>A0A654E3U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="17960" checksum="FC4020ECDE60B617" modified="2020-04-22" version="1">MKKPQVIILTLIALAMACSKEGGENRATFPKLRLVTDTGVDLLNPDSPESYDQNQMEVWTIQNDSKVSGKIEIWPREITAMDSSLFILGVDLFYRGSRYIEDTGNKEFFIRLTESDIDTITWVVGGTSSFNTWTSEVKYNGQTVELSELQDYYVIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E403</accession>
    <name>A0A654E403_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023917">
        <property type="entry name" value="Bifunctiontional_GlmU_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13562">
        <property type="entry name" value="NTP_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03991">
        <property type="entry name" value="alt_bact_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="45577" checksum="BCF43FC082674A5C" modified="2020-04-22" version="1">MKSSGICPEDFFIFAPMSILFAEHPEAHQQLLPLTYTRPIADLRVGILTIAEKWARRLDAAPFGFETLPYLQEKFTTLTAEENTLWIVNGLLPDDSLIQAVKTLKPGQVLRHGEHPLAARGKHNPLLHTDYQPVSFEESYDQISYTWHIFQLNGAEIRKDFELITKGRTSQPITDAHTMTYGSDIFLEEGAQVRAAILNAENGPIYLGRNSEVQEGAIIRGPFGMGEGSIVAMGSKLRGDTSAGPQCKMGGEISNSVFWGRSNKGHDGFLGNSVLGEWCNLGAATNNSNLKNNYDPVRMWDFASGRFVHTDLQFCGLIMGDHSKTAIGTLFNTGTTVGVAANIFGEGFPRNIIPSFSWGGAKGFVTHQPRKAFITAQVVMKRRNLELTEQDKNILNHIFEASAQYRVWEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E421</accession>
    <name>A0A654E421_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23962" checksum="2D3997EC459B157B" modified="2020-04-22" version="1">MGSADVQTEKLIKDKAKVLFFQKGYLNATTQEIADEAGVNRALIHYYFRSREQMMDTLLDEALVEKKEKVRKILTADLPFREKIANYIETMVDHGLTYPYLDNFIISETARYPDKVRAFCSRDSIKSTDLIQEQLEEEIAAGRMVPISPQDFMVNLAALCNYPILAKPVLKTIYGMTDTTYREFLNERKQTIYMTLFGERMPQTQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E433</accession>
    <name>A0A654E433_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppiA</name>
        <name evidence="7" type="ORF">MARINOS108_10790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="15896" checksum="AA369C23C5AAFEF2" modified="2020-04-22" version="1">MKKAEIHTKKGVMKINFFEQDAPKAVANFISLAEKGFYDGLTFHRVIPDFVIQGGCPKGTGAGGPGYTIDCELDGDNQYHDRGVLSMAHAGRNTGGSQFFICHSRKNTAHLDRNHTVFGKVVEGLEVIDAIREDDVMEKVVITEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E439</accession>
    <name>A0A654E439_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="24581" checksum="737968FA18E46F67" modified="2020-04-22" version="1">MNIRNRFARSQGISNEIPNKQLASEIVASSDEASIREILQILRESKKPDELSDGLKVLEMVGEQNPGLLADAFTPVFTLLQHTQNKIQWRAMSALSTFSFLHPATTFDNLGVILDLMDQGSVITRDHGVKILIGLYKEDAYRRDIGPLLLEQVTAAPDNQLGQYAEKWMQVITQEDRAKLIRVLEMRQPELVNPSHQKRISRVLLKLHRSQKNFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E445</accession>
    <name>A0A654E445_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="38780" checksum="C61A08C05413BCC5" modified="2020-04-22" version="1">MSELIKILYVDDERGNIDYFRSVFRREYEIVTANSGEEGLDLLFENQDIPVILTDQRMPRMSGVEFLRRSINISRDSIRILVTGYADMETVINAVNLGHIYYYISKPWTYDEMKIIIKRAIETYRLRLINKELLIKSERVEKERVVAQLENLRNQVNPHFLFNCLNTLHALVHDNSQARDFVKNLANTYRYLLEHNDNLVSLESEMNFVENYIYLQKVRFKDALMFTHSVSEHHKYFKLPSASLQLLVENTLKHNIVTRENPLKVEVFIEGEWLIVKNNYQPKDARQESTGIGQDNLKKRLSYLSLSSPEFYLEGEFYIAKIPLLLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D4</accession>
    <name>A0A654E4D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="226"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="536"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1182" mass="128876" checksum="51C6B4A0FC64E472" modified="2020-04-22" version="1">MKNNLLREILTMSKLLFQVLFLQVIFATFLYAEETSAQNKSVYEIKVSIHAKDVSVIEVFKQLEEKTDFLFTYNDENIDANKVTLNRRNKSVGEILEDLSGLTDLRFKRINDNIHVNRSQAKNVSVEENYLTRQEFTVSGTVTDEDGAELPGVTVLIKGTATGTVTDLNGAYKLAVSDADALVFSSVGFLTQEVAINGRTTIDVAMNYDVQSLAEVVVTGYTSQRKADITGAVTVVDAEALNAIKAPSFSQKLAGRATGVTVSNSGSPGGGTNIRIRGISSFGSSDPLIIVDGVQIQGDKAMNGLNPNDIESMQILKDASASSIYGSRANAGVIIITTKQGKPGKIKVTYDGYAGVQNPVGGYNDILIKDPVDYARIQIAKNPALTNYYGGDPNNPVIPDYFFPVATSDNGTPDNADDDFLIPANPNEASYSFPDNLIMRSNKDGTDWWDAVFDPALITEHHFGISGGSENATFSSSVGYLKQDGTMINTGFERLSARLNSRVNSGKFTFGESLSVARSETVDQQGGNQNEQNTVTQTLLMNTIVPVYDVAGNYAGGKTNGFSNGKNPVAFAKNNKHDIGTDFRVLTNIFGEYELIEGLKVRSSFSVDFRQNFQPSANFPRYEDREVNSSNSYQETHQTYLNWVWTNTLEYNKKFGDDHSLKLLAGQEGVKNQFKQINGQVNDLAFIDPNVRFLNLSYSTFSSIGSQERVVALSSVFGQVDYSYKDKYLVSGVVRRDGTSEFLGDNRFGVFPAVSVGWRVSEESFMNGVSFIDDLKVRGGWGITGNQNIPVSYNAYDRYGGRSPSDAGYDLGGTGGSMTPGFTLYRYGNPNTKWEENESMNIGLDASLIDGKVSVVFDVYQRDINDLIFDPTNAGSAGNSQASFRNVASMRNTGWDLGLGYRERFSGDLGFNAFLNLSHYKNEIVKLDGEASAIFPAGIDKRFGEVNVWQVGSPISSFYGYTNDGFFQDAADVAALDQAGAAIGRFRRKDLNGDGVINGDDLGVIGNPHPDLTMGLNLGLDYKGFDFSVMLFASIGNDIYNYNKLFTHFGQFNSNMSKDVLTDTWTENNRNASLPKLDGGDTFASQSSDFYVEDGSYLRAQNITLGYTIPTAGISSISSLRVYVQAQNAFTITGYSGIDPALSNANIGTAVDGRLQNDGWTGYDLGNYPASKIFMIGVNAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F5</accession>
    <name>A0A654E4F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024948640" evidence="2">
        <location>
            <begin position="22"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="37869" checksum="5AEB0D5F1C45EAA2" modified="2020-04-22" version="1">MKQLTTLCLLLAGLCSYSQSAEGLLIFVEDYTQDKRINDKDIIFVYYPGINEMIEKEEWDRKDIDLSINDISLKEITPRRIPRTIAMPGEEEDSIRTDLLAFVIQKEKLSREQLDGLRNLESMESAFVILSLPNDADLQGTLTIYGLTRTRYLQIGAWVAVAIIAIFLIYVGFWTNALRDSSELESHKPYSFSKSQVFWWTLIVISSIAYIFISTSQFALNPTVWILLAISGGTLGVSSAIDRRDINSVGISRHQDSPGEDWFNDVLKDNTGSISIHRAQAFLFNLGFGVYYLIEVYNTLQLPSFDSDILTLLGLSNGAYALIKNNENTTSADSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K0</accession>
    <name>A0A654E4K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6233" checksum="2AD74536BCC48591" modified="2020-04-22" version="1">MTHQELENEIKTLEGQLTGDMFQDMDIRDKIHNLKMTRDGIKPANQVIECVGCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E507</accession>
    <name>A0A654E507_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="310" mass="33923" checksum="820077C99866FF64" modified="2020-04-22" version="1">MSKEFKVGLIALVTGVLLYYGFNFLKGIDFFSPTHKYYAVYDNVDGLNKSNPVIINGLTVGRVSRIRLLQNQGNLILVELDIDETITLGDSTVASLMNTDFLGSKGIVLTVGPLNNPIQPGDTLTSYVDKGLNEILASAEPVASNLNTTITRVNEILIGLKGSGEKINATIEEVRKTTVSVNEIISENQAELAVIMTRTAILIQTLNTKLDKIDPILVKTGGVLDSLSNLEINQTLASIRGAVDNLNVTINEIKSEEGTLGKLISDDSLYNNINQTMTDLDKLILHMDQYPKHFFSPLGKSHKKVMEDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E536</accession>
    <name>A0A654E536_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">ppk</name>
        <name evidence="12" type="ORF">MARINOS108_90143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="129"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="340"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="512"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD21502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="700" mass="81745" checksum="9575EC3258E4D099" modified="2020-04-22" version="1">MIEKYDHLIQQSDLISRDLSWLHFNYRVLAQSMKEGRNLFDKLKFVAITASNADEFFMIRVGSLYNYLDYGKDRVDYSGLRAVPFKRKLLHDFQEFSRVQNDHFINNLRPEFNNHRFQILGYGSLQKREKERVTNYFEKIVFPMLTPMVYDSYHSFPILMNNILVFGVVTKTQDTKEKRKMSFIQIPQNLPRFYEMERKDKMIFVPIEEVVRQHISEVFKNVEITSSTLFRVTRNGDFTLEESEDVEANFIEEMKKKLKTRKTGRVVKLEVEGEYDKWLIKQLRTKYEIDEDNIIEVPKGALMDYTGLWQIVKHEDFRDFRPEMPKPVPPLSMSEYEHPDMFKILKDRDILLHHPYNSIDPLMDLLDQAAEDPNVLSIKLTIYRLAKNSRVVSALLNAAENGKHVSVLFEVKARFDEENNMKEAQRLQKAGCFVIYGVGMLKTHTKLLLIVRREGEKVKRFVHMSSGNYNEDTARLYTDIGLMTSDEGYANDVQEFFNVITGHSVPDRYDNLITAPREMRSRLIELIQQEENNAKNGLPSGIVIKINSLQDIDTIMALYAASRAGVPIHLIVRGICCLRPGRPGLSENITVRSIVGEYLEHSRIFYFHNQGDPLVYSGSADMMVRSFERRLESLFLIKDELLKQQAINLLCYNLKDNINGYEMKEDGSFVPITPENGKVFNIHKEFYKVKREVVMSAKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E538</accession>
    <name>A0A654E538_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ilvK</name>
        <name evidence="14" type="ORF">MARINOS108_20734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD19444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="354" mass="39128" checksum="58C000847549E412" modified="2020-04-22" version="1">MTETIDINITKTKHSKIHEADLEKPQFGSVYSDHMFLADYSNGQWQDLRIVPYGNLSISPANTTLHYASTIFEGLKANRSADGEILVFRPDANARRLQASAERMCMPPVPEELFMSGLTELLKLDSSWVPSAPGTSLYIRPLQLAMDPYIGIRPSNSYQFLIITGPVGAYYAEPVKVKIETKYTRAAQGGTGFAKTGGNYAAALKPAVDAQKEGFNQLIWTDAKTHEFVEESGTMNLMFVINDTLVTAPAGDTILNGITRDSIIQLAKDKGMKVEERPVRVSEVIDSIKNGSMQEAFGAGTAATVAQIKLIHHEGVDYHLPPVEDWKYSADFLDTLTKIKTGEIPDPHNWIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E551</accession>
    <name>A0A654E551_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="45"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="35659" checksum="4F3539F6A91676C3" modified="2020-04-22" version="1">MKILKILGIIIAGVILLALCGIAFIKTTLPDVGPAPEVSIAVTPELVARGAYLANSVTVCMDCHSTREWSKFSGPLKPNTLGQGGEIFNQDFGFPGSFTSKNITPAGVGDWTDGELYRLITTGVTKDGNPIFPVMPYKRYGQMADEDIYSIIAYIRSLAPIQNEVTPSEADFPMSIILHTIPQPGNPQPKPDKSDVLAYGAYMANAAACGDCHTPQDKGAPIMALNYAGSFEFNMPGFGIVRSANITPDEKTGIGSWSEDFFVNRFKAYADSSYVPHTVGENDMQTVMPWLMYATMEEEDLRAIYTYLRSLPAIENKVVKFTPASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E583</accession>
    <name>A0A654E583_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="25117" checksum="5AC2F941EDBB9AFB" modified="2020-04-22" version="1">MCEIDWDILHKYVDSLVWPILVLGLFLLFRNQITKLINRITNESEQIELGGLIKAQFKQVGQLREDVKTGKATGEQTDKVISATVTVQVEGIKLLGQDYIHSNYDQRRILESRISDYSIGLETGDIQDLLDSKDTGHRIGGAIALEHILYRTKTDPAENAKVKQFIIESLADSNSFLRYETLQLVFQSSKLLTELKTKLEEMKNFDKNPAIKTLLKMYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G5</accession>
    <name>A0A654E5G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fasciclin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024919604" evidence="1">
        <location>
            <begin position="30"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="239"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="419" mass="42865" checksum="4653EE3730332A53" modified="2020-04-22" version="1">MMMKNSINPLKVLAMLAVVIGLAFTTSCGEDEPSCTETTWYADADADGLGDANTSVSACEQPTGYVDNSDDDDDTQGEPTKTIWELVQSTEGLDSLEKYLGVYPDLVATLGASGTFTLFAPNNDAFVNLLATPGFPAQITSINPDIIKNVLAYHISVTSYLKADLTSGKQVTTLATGQGVDVNSVDKIVVNADGTLLTGSSNNAIAITGANKKATNGVMHVVGSVLIPQTVGAQLTPILGTNAGTLLLGADFSLLAQAIFKADTFAAQNSLPTIYSMLSGSATHTVFAPSNGTFHVAADTKAGNSDGTASEAEIKAFMSGTPAQSFYGIITTQIVLSEVLSTSLTQGAQFTAASGATLTVLSTEAPTDPAKGILTGIVIDSNGDTTPEAQVAVPASASSSLVTANGRVHVIAGLLSPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I8</accession>
    <name>A0A654E5I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="275" mass="31320" checksum="9AFC5D8075050E04" modified="2020-04-22" version="1">MKALFVVCFAFILGTGWSQDLSVMTYNIRLDHAGDGVNRWDMRKANMVAQLGFYEPDIFGIQEGLPHQVKYLDSALADYAYVGVGRDDGAEKGEFSAIYYQAEQFNLLQSGTFWLSTTPEKPSVGWDAALPRVCTYGLFEKKSDGQKFWVFNTHFDHIGVEARVNSMKLILDQMERFNKQKLPTVLMGDLNVEPTEGPILEMTRKLDDTRAVAKLTFGPDATFNGFRFEETPQKRIDYIAINEQFDALKYAVLTDSNDQKYISDHFAVYCELAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E645</accession>
    <name>A0A654E645_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unsaturated rhamnogalacturonyl hydrolase YteR</fullName>
            <ecNumber evidence="1">3.2.1.172</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yteR</name>
        <name evidence="1" type="ORF">MARINOS108_90030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.172" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102211">
        <property type="term" value="F:unsaturated rhamnogalacturonyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="45787" checksum="BB0BBBA46B10F65C" modified="2020-04-22" version="1">MKNILYLIGIVLLASCTPPKETAENQTETPLYVRMADSEMKRTPDPRLLDFRDKPKWEYTNGLVCLSFFKVWARTGEDRFLDYGKYYMDSMITDEGKILTYKLSDYNIDRINPGRFLIELNQLTPKPEYKVAIETLREQMREHPRTSEGGFWHKKRYPSQMWLDGLYMGSPFLAQYAMLYDEPALFDDVANQFKLIDKHAYSKETGLYYHGWDESREQKWADPETGLSPEFWGRALGWFSMAVVDVLDYFPEDHPKRDSLLMIVNKIALGIQKHQDPASGVWWQVLDKAGKEGNYLEASCSSMFTYFLAKSIQKGYLDSSYAPMTKKAYAGLIKEFIKENEDGTISLTNVCGVAGLGGDPYREGTYEYYVGEIRRDNDPKGVGPFIMASLWMEKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6Y0</accession>
    <name>A0A654E6Y0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">pdxH</name>
        <name evidence="10" type="ORF">MARINOS108_90058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD21309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24506" checksum="16BBD09C18A90A3D" modified="2020-04-22" version="1">MSLDLASLRQEYTKASLDLDSVCASPFDQFQQWFDEAQKSKVTEPNAMVLSTSDLSGHITQRTVLLKAIDPNGFVFYTNYKSRKARQIEENPQVCILFPWYQLERQVIITGRAEKVSTAQSMKYFLSRPLGSQLGAWVSHQSEVITSRSILEMKLQEMKAKFKDGKIPLPDFWGGYKIVPDSIEFWQGRASRLHDRILYTRSDSDWSTQRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E877</accession>
    <name>A0A654E877_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="136"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="275"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="39451" checksum="273FB2B8508FA96F" modified="2020-04-22" version="1">MDYKKYSIEDFVLDKEFRKWVHTEDEAVNTFWNDWVKRNPGKLSEIQEARRILKNLNFPAYKLTPSEKEDLFEGISGRISGADSSEVKMRYLDVDGYQGKSPRWALRFGVAASLIIGVAWLVMLLVQDSRFGQLAYHTDFGETKEVKLSDGTMVTLNANSKIYIGELGAEGQAREVWLEGEAFFDVTHTQTDQAFIVHANKLDVNVLGTEFNVYARGKKAEVALASGKVRLANTASKQELEMKPGDRVVYESVYQKPVKDSFDPAEVSSWKKNLLIFRRTSLEDISDLLKTNYDIDVFFTGGASSDHYFTGTTPADDIDLLLKTISKSFDLHVERKEKTVIISPNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8C2</accession>
    <name>A0A654E8C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="134" mass="15834" checksum="81E7840F69127748" modified="2020-04-22" version="1">MEGYDLYINDKSGTIWGLVKAYALRNADHIEFNILYEGRQLDEFILKNRDSLVERGKKKNKLFRSGEYLRFLFSDNLKSLIENIDFGYFKNYCVEDVSFYTDECEIISTITHEDQIYLKKGSAINSLIRTKYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8M6</accession>
    <name>A0A654E8M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009474">
        <property type="entry name" value="YphP/YqiW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40052">
        <property type="entry name" value="PTHR40052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06491">
        <property type="entry name" value="Disulph_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04191">
        <property type="entry name" value="YphP_YqiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15038" checksum="624ECFBAB945F363" modified="2020-04-22" version="1">MYPEQLVAPMRTELTHVGFEELKTAEAVDSLMKDHKGTSLIVINSVCGCAAGTARPGVTTALNLSAKKPDHLATVFAGVDMEATAKVREYTMPFPPSSPAVALFKDGELVHFVERHHIEGRSAEMIANHLVEVFKEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA51</accession>
    <name>A0A654EA51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18160" checksum="E4E8DD79317CB20C" modified="2020-04-22" version="1">MNAQYWIDKLGLEPHPEGGYYKEVYRNPNTIQIMGGGGTRNLSTSIYFLLEGSQKSHFHQLSSDELWYFHAGSGARVHVLNHGEYSEHLLGLNLEAGDLPQLLLPARSIFASEVSAPDSYVLMGCMVNPGFDFKDFRMLTASELEESYPGQKALIREFTLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA67</accession>
    <name>A0A654EA67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13602" checksum="968B05310BCBC328" modified="2020-04-22" version="1">MKLRAIAIDDDPTSILMVQKLASKIDDLELVNTYESPIEGAAGIILDRPDILFLDIEMPEFNGIDIMSTLVKPPKIIVISGNPLFQSQALELDAVAFISKPPQEEEFNMAVNKVRAHLLEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA70</accession>
    <name>A0A654EA70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose synthase/poly-beta-1,6-N-acetylglucosamine synthase-like glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="381" mass="43244" checksum="380E634FAEB9A65F" modified="2020-04-22" version="1">MNITILWLLSLPTKPYRVLEYFFYTFAFLHFLLITQTIAPLLRKSSTTQLNTLSPPFSVIVCAHNEVKNLKKLMPLLLAQQYVDFEIIIVLDRCTDGSIAFMQSVNSAQVLTIEVPAVPDGFNPKKYALTQGINAAHNEWLLLTDADCRPVSDQWIASFAPYTSEKTELILGISPYESQPGLISQITTYETLQTAIHYTSAAYQGRAYMGVGRNIAYRKSTFRKAGGFHPFEAVVGGDDDLLVQKITTPHNAAINFKSDSLTNSSPERKWKGYLKQKTRHLSVGKHYQPAVKTAHFIRASTHGVLWLCFLYLLFSFQYSSRIIVLFGLLILVKGVFFKKIANNLGMPFNRIWFPLVDLIYAIFLPLLGVRAMFVKNIRWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAW5</accession>
    <name>A0A654EAW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ADP-ribose pyrophosphatase YjhB</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjhB</name>
        <name evidence="2" type="ORF">MARINOS108_140038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="23943" checksum="D4763B467182FE34" modified="2020-04-22" version="1">MRPTTSMDMNKQVLEYLKRVQSLAKTGLTYAEDAYDRERYEELKESTNNLLSALVGVEVERIVAQFENLDDYPTPKVDVRGVILKEGKILLIREKTDGKWAMPGGWADNGYSPSENIVKEVWEESGLRVRPERLMAVWDKRKHDHPADVHSVYKLNFLCIEEGGALNPGHETIGAAYFPIDQLPELSLMRNTSAQIQKLYELALSGGVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE44</accession>
    <name>A0A654EE44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4036" checksum="DBB32A75491E1081" modified="2020-04-22" version="1">MVTAMVMVTAMATTKNLNNSPTFVASSGNICLDGFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEG9</accession>
    <name>A0A654EEG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall bisynthesis (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34286" checksum="F0A1D18FDA31BA9A" modified="2020-04-22" version="1">MAFILLVRDKTSGKGLIAVPDKPTISIIIPTFNAELTLRSCLDSVCHQSYSSYEVLLIDGNSTDRTLEIIEDYKGYGVKWISESDTGIYDAMNKGVAMASGEWLYFLGSDDQLYENALSAIADHLYYPKVHFVYGDVFFKHSGRRYGFEYTNEKLAERVICHQAIFAHRSLFVRCGLFDQRYKSCADYAFMIKAFGLNPNHNFYTNEPIAVFDERGFSAAHLDLPFLRIKHKLCKTHLGIDSNNEAYFEHLSKEGNHEIEAGSMMTGIKMSIVSVLLGRNKMRKLLDVLYVLKKRFFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEJ1</accession>
    <name>A0A654EEJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="21210" checksum="DB591B471FBC6DB7" modified="2020-04-22" version="1">MENIKRREALKRTAWIMGGVLSAPTVAGILNGCTPKPELTWTPTFFSEDQARLVMQIAEGILPETDTPGAKSLGVPGFIEEMVSVVYDQGAREAFIKGLEQFEADCDSQMGDSFIALAPEKQTEFLQKQNSELKNWENGRPFFWTIKELTIVGYYTTEYGATEALQYQAIPVEYHGCSPLSETGNGKVWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF92</accession>
    <name>A0A654EF92_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">dxs</name>
        <name evidence="12" type="ORF">MARINOS108_60133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD21003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="638" mass="70750" checksum="DAB983FDD8AAEBCE" modified="2020-04-22" version="1">MEIRPGKLLAEIDNPNDLKKLDETQLAQVAEELREYIVDHVSVYGGHFGASLGVVELTVALHYVFNTPVDQLVWDVGHQAYGHKILTGRRKDFHTNRLYNGLSGFPKRSESEYDTFGVGHSSTSISAALGMAFGSDYKGEKEKHHIAVIGDGAMTGGMAFEAMNHAGDSNKNLLIILNDNCMSIDPNVGALKDYLTDITTSPTYNKIRDDVWKVLGKISKFGPNAREIVGNIENSIKSLLLKQSNLFESLNLRYFGPVDGHDINHLVHVLRDLKDIPGPKILHCVTVKGKGFKLAEQDQTKWHAPGKFDKITGEIRKTVVTEPKPPKYQDVFGHTMVELAEQNNKVMGITPAMPSGSSLNIMMDAMPDRAFDVGIAEQHAVTFSAGLATQGMVPFCNIYSSFMQRAYDQVIHDVAIQKLPVVFCLDRAGIAGADGPTHHGAYDLAYMRCIPNMVVAAPMNEQELRNLMYTASEFKDGPFTIRYPRGQGVMPVWRTPLEQLEIGKGRLLRAGEEVAILTIGHIGNYALKACDELEKQGIRVSHYDMRYVKPLDEALLHQVFEKNKKVITVEDGCLPGGFGTAILEFMADHNYHAKVIRLGIPDRIVEHGEQDELYQECGYDAEAILQATYKLLELSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSZ4</accession>
    <name>A0A654DSZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6114" checksum="AC583732AA491E32" modified="2020-04-22" version="1">MGLFSEIGQSYESHFENDYRDLEPPFLGSVISSALSYPSTELRLTKQQFLRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT51</accession>
    <name>A0A654DT51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">MARINOS108_10255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="61"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD10839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="43560" checksum="C1A73B18B1CCF3B9" modified="2020-04-22" version="1">MSEVKSKYLVDERGYFGKFGGAYIPEMLYPNVEELRINYLEIMNSPSFQKEFQQLLRDFVGRPTPLYYASRLSELLKAKIYLKREDLCHTGAHKVNNTVGQILLAKALGKKRIIAETGAGQHGVATATVCALMGIGCIVYMGEVDMARQRPNVERMKILGAEVRPAKSGSKTLKDATNEAMRHWINNPQDTHYIIGSVVGPHPYPDLVARFQSVISEEIKWQLSEKEGRDHPDYVVACVGGGSNAAGAFYHYLDTPEVKLVAAEASGLGDHTGKSAATTALGREGVLHGSKTILMQTDDGQVIEPYSISAGLDYPGIGPFHAHLFDSGRATFYGITDEEAMTAGVLLSRMEGIIPAVESAHALGALHKMTLDPQDIVVVNLSGRGDKDLETYIKWGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT92</accession>
    <name>A0A654DT92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025046854" evidence="2">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="32380" checksum="FF72F62B03C53EB8" modified="2020-04-22" version="1">MKQLLTLILTLGVVYIAQAQFTEDLSGTLNTTDKVNIKSGRLNVFRDSDNWGIIYSKHFDSPANQSLHLNYYGTGPTIIGTGGGDLYVQNNAIFNGNILIKNNQFIRGERSGGGVSNLIGYNPVESGNHILAFSEYSSVPSEVRIYTPTDQNQGVSIYSDKRLVFFRNDGNVGIGVDSPNNKLSVNGTIWAKEVKVSMTDAADWVFEDGYELKSLDEVEKFVRLNKHLPDLPSADEFRENDLNVADMDNKLLQKIEELTLYMIDMNKRMNQLEIENSELKGKVQLLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTB2</accession>
    <name>A0A654DTB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="685" mass="77368" checksum="D3215E2768A12925" modified="2020-04-22" version="1">MKIFSAIIGVLCVFFANGQVQPEEVEIMRDAYGVPHIYAPTDPGVAYGLAWAHAEDDFQTIQLTMLAGKQMLGLHLGKQGAAADYVVALLGCRQVVDTQWETLSPAYVALITAYTDGLNAYAARYPEKVLVEGSFPITVKEVLSAYVLSLAVISGADQVIGNLVKGNVAEAPDLSGKGSNAFAFARKKTADDYVYLNINSHQPLEGPTSWYEAHLVSDEGWNALGGLFPGGATIFHGTNENLGWAHTVNYPDKIDVFQLEMDSENGLKYRFDDEWKTLDSEEIKLSIRIIFGIKIKVKKLVFRSVYGPVVKNEQGFFAFNLGALHDLRAPEQWYRMNKATDLKSFKSALEMVAIPGFNIVYADRDDNIFYLGNAKIPRRDPQFDWSKTLPGNTSKTLSGEFHPLEDLPQVLNPESGYVFNTNNSAFSCTAIEDNPNPEDYDPTMGYREFENNRSTRFRELMDQYDVLSWEDFLAVKYDDTLPQQLAYPADLSALFELDSMKHRKYAELIKILHEWDRSAHFNNLGAAQFMILYRHLVDKYRSKYTGVPYPLSEAEAWEAVAYTHAYLKKHFKRLDIRLGDYQLLVRGPYEMPVNGIMDVITAMDAVPYRDGRVRASQGESLIMLVRYPEEGLPIIETINVYGASNQPDSPHYADQMLKFVKQQRKPMTLDIEEVRKTATSVYHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTC9</accession>
    <name>A0A654DTC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="3 6">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="PTHR11624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="325" mass="35837" checksum="0EAC449F12D833DD" modified="2020-04-22" version="1">MREIQFRQALGEAMSEEMRRDPKVFLMGEEVAEYNGAYKVSQGMLDEFGPDRVIDTPIAELGFAGVGVGAAMNGLRPIIEFMTFNFSLVAIDQIINGAAKIKSMSGGQFDSPIVFRGPTGNAGQLSSQHSQNFENWYANTPGLKVVVPSNPYDAKGLLKASIRDDNPIIFMESELMYGDKGEVPEEEYLLNLGEAHTVKSGTDVTLVSFGKMMKVAIEAADLMAKEGVSVEVIDLRTVRPIDYKAIVESVKKTNRLVIVEEAWPLASISADISHHVQRHAFDYLDAPIHRVNSMDLPLPYAPTLIEEILPNVKRTLDAINAVSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTQ9</accession>
    <name>A0A654DTQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="382" mass="42947" checksum="C07326E05D8161E7" modified="2020-04-22" version="1">MHATSYLEDMKQNLILTLALLGLASIGNAQQVIPLDTALWEINAQSYVLENYKGQQAIYLQGGSMSPKQVTFLNGTIEFDIFLKEEAAFPGMNFRSVESGDMEQFYLRPHLPGKPDANQAAPAVKGVTPWQLYFGSKYSFPYDYKYDDWTHVKIVVNGDKAQVYMDFSEKPHLSWILFHPAQAGKVVFRGGGASGMHLANMRINPNAYELVDFQPGIREPIEGLVPAWQVSDMFEEKGLEDLEDPANLQRLIDERKWGGTIKVEEGTAANISRVQTLYDGSPGETVFARIIIQSEADQVKLFHFGYSDRVVAILNGQPIYRGNNRWHSRDYRYLGTIGLFDAIYLNLKKGENTLLMAVSEDFGGWLITGKFDNPEGVTIKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS4</accession>
    <name>A0A654DTS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endosialidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S74" evidence="2">
        <location>
            <begin position="731"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="800"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="868" mass="91560" checksum="4D465AFB178D45B8" modified="2020-04-22" version="1">MKYLSLVFALCFTLSSYGQKIPFQGKLTENDEPVTGTKDLTFSFESTEWTETHSSVSILDGFYSVVLGSITPLPDDLFESSDEASLIISVGEISLSPITIYQPYKQKVFTDTYDGTTDQPALTVNRSGSAGSSFAAAEVIAEMDDDSYALYGQATGAGSNYAVYGYANGEGATNWGTFGIARGAGDGSEGYGTGSYNNGAVGYARDNIWGNTGVWGRAYGAQGVDNIGVAGWAEVNNGSDTILNQGVLGRALGPGINYGVHGIAEAGVENWAGWFDGNVNVNGELMVNGEPFSGGSSTGVPDSIEATDIKLLNAEGKLRTHLNIYEPTNAGSLVLYGANDSTKVIVGSSYSGYGGYIGLYDSLRNQGARLFVNTKGVGNLYTYDANHKVAGWFGNQGNTGGFMQLAGYDQSGVFTGATYTGMASWNNGLPYFIMEGSSEDPFTTLVEFGASLNGQSSEVPYFNMNSSTRAINGQSAAISLGVSEQDLGFLELHGGNDRNWDVRAVLQVDSVGSLGTAGRLELLGPLGDVDNNVKGIMRVGANNDAGGTDPSGVSGEMILFGTNTPNVIMGGKQWENNDLAKMELLGSKSDGGSWALPNIGLDVFSDGTYDAGAINMFNTVDGASFQTVSLSSNGSNNGAQFTLSSADATNMVTIESSATDGVQGGEITLLSSVPGSGIRMYGGTDFSADSNPVAQSHIAVHDSDSTYVNLWGSGDIDVSGTISGQTVVQTSDQRLKDNIQTQMNSLEKIKSLRGVTFEWKSDPSNEQHIGFIAQEVQEIYPEMVTTNEDGYKAVNYAVLVSSLVEAIKELDKKVNMLADENAKMKAELSAASSKSSEIEQLRSEIASIRELLLSPTKESEATTIGQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS8</accession>
    <name>A0A654DTS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14809" checksum="6CF9239454B65254" modified="2020-04-22" version="1">MIQLARYIVILFAAFLIYVGFLMLLNPVKAREYLRKAGSTNFINYFEITIRMIPAAGLIISAELSKFPEVFTLLGWFMIATSFILYFVPRRLHHHYALWCADILKPAYIRLTAPFSMLFGCAIIYAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTU6</accession>
    <name>A0A654DTU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgcA</name>
        <name evidence="11" type="ORF">MARINOS108_10066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="206"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="321"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="574" mass="63446" checksum="D320B74A1E9C2CF5" modified="2020-04-22" version="1">MEVTAKAQKWLASQKVDQDTKTIIEKMLADADQTELTECFYKDLEFGTGGLRGLMGTGSNRMNKYTVGMATQGLANYLNQTFAGEEISVAIAHDSRNNSRFFAETTAAVFSANGIKVYLFEALRPTPELSFAIRHLGCKSGVVLTASHNPKEYNGYKAYWDDGAQMVPPHDVNVITEVGKISSIDDVNFDANASLIQSIGNEVDEPYLDMIQSLSLSPEAIAQEKDLKIVFSAIHGTGTTMVPPILKRMGFENVTEVKEQAMADGNFPTVIYPNPEEAEALSLALKKAEEIDADLVMATDPDADRVGIAVKNDKNEFQLLNGNQTGSLLLYYLLRKWKENGKLNGKQYVVKTIVTTDLIEKIAEKYNVKLYNTLTGFKYIAEVIRELEGKEEFIGGGEESYGYLIGDAVRDKDAIASCAMIAEMAAWAKSEGTSLYELLKNIHNEFGLYQESLKSITKKGKTGAEEINEMMVKFRQNPPSMLAQSKVMTMIDYKAGTSKDLTTGKEEKIKFPASNVLQFITADGSKISVRPSGTEPKIKFYFSVNEQISAPDKYYETIGLLDKKTQIVVKDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU34</accession>
    <name>A0A654DU34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="263" mass="28843" checksum="6C195EEE4DC54F88" modified="2020-04-22" version="1">MELQLIRNATLKINYAGSTFLIDPYFAEAGTQPSFAGKAKNPTVPLPMSTEEILKGVDYVLISHLHPDHFDEAAQAIIPKDLPIYCQPEDSETIRAAGFQAVHPIEDQVDIGGIRLSKTQGQHGTGSILPLMGEVSGFVLSHKNEKTIYWCGDTIWYEGVKENIDWYQPEVIVCHAGANKFFQAHNVFGPAFTGDSEVLIMDAAQVSDLCHHAPESQVVVTHVGALDHETVTRAELRAALKKNIGAGQLFIPEDGQSLVFDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU88</accession>
    <name>A0A654DU88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024854766" evidence="1">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="35478" checksum="E91BB587A496DFA3" modified="2020-04-22" version="1">MRHFITALIIFSAYLSHAQGCSDAGFCTMGAMKPDQAYSKKVNFKLRSLELNYYRGTSLLTPVITVFTSDMTFGINDYYAIQVKVPYQMVTGSLGETQGLGDLSISASRSIRLANGSTVGITLGGKIPSGKSDIENNHSEFGSGDLPMYYQVSLGSYDAVAGASYINEKWLFATGIQRPLIHQNENDFRWGKWPDYPDPSYIRKYNLANDLKRGTDVMLRAERNFRFINFNFGIGALAIYRITKDEVYNFNEDKREKLNGTTGLAFNMLANVGYQFNINNSVKLIYGQKFMDREVNPDGLTRHNVFSFSYVYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUE8</accession>
    <name>A0A654DUE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="26442" checksum="5447D7C40D9E2E72" modified="2020-04-22" version="1">MKNKINKQQLILEFVSVVFAVILALVLNGWRESSALNANLVKVEKSILKEVQRNDSLIRQSHTYRGDLLQKLYSNQNLLLAVSTSDLDFDVNNNSKLVDFFKTALLFGQKEYHTVQVVQEGGDRVLILDNSVFDLKLEAGTLQVLGLGNVELKIPDLNNQSWDLAKATGTITEMDIALVEKLGTVNALIETYLKTSESAVQLVYSGAQKGLMPVLEDLYNLESKIMKANSQLLEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM4</accession>
    <name>A0A654DUM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4484" checksum="2608DC8184BAEFC9" modified="2020-04-22" version="1">MRDDKGDGRNQATLQIKEITYDLFVTTETEHKDQIGSDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ3</accession>
    <name>A0A654DUQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding universal stress UspA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="229"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="31201" checksum="C9A2F4F92C87C7AA" modified="2020-04-22" version="1">MKNILVPYDFSDVAHHALNFATDLARKGSDCKVTLINVIEQPTPDTIKTMGIVGHDPMQSLYIKMLIDTAKGKMEAIMADSSYKDITLKYKIVLGQPFKEISEEIKTSGIELVVMGTSGSSGAEEFLVGSNAERMVRYSKCPVITIAKATSASDVKDIVLASNYHDVPTSFVEHVKKLQKIFGAKLRMVKINTPASFTSTRHDRKQMEEFISKFGIENYTHESYNFSNEEDGVIAYAEDIGADLIAIGTKQRRGVGHFLAGSIAEDVVNHSQVPVWTFGLDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR1</accession>
    <name>A0A654DUR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-subunit dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="29046" checksum="186FC3C022ED6067" modified="2020-04-22" version="1">MTKIADKVIMITGASSGIGEALAYQMAEAGARLILSARRKEELDRVKSACSHQENIRILPLDLADAFAISQKAKEAESFFDRVDILVSCGGISQRDKVIHTKMEVDRQIMEVNYFGTIALTKALLPGMVKRKSGHQVVITSAVGIVSTPFRSSYAASKHALHGFYDALRAEHHADGLKVSIILPGYVKTKISFNALMGDGSKQDKMDNAQDNGLSPEECAAKIIRAVERDKEEVYIGGFREVTGIYLKRFVPGLFSKIIRKTAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR6</accession>
    <name>A0A654DUR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="40390" checksum="0CE56650E2ED771B" modified="2020-04-22" version="1">MMNRKLRVGVMLVLCAYFTITALAGQNIRFLKEKHDFGEIHEEGGAVKYAFLFVNTGADPLEIKNVEASCGCTTPDWTDSALMPGDTGFVVAEYDPLNRPGKFEKSLNVSYSAGRSGSASATLYIEGMVSPRASTMEDELPLLLGQIRLKYKALNIGRVTTEKVVTESFKVYNEGDSAVRWLEDKSSLPGHVQVVFDPVVLEPKTLGEIRLTFDPVKKADLGFVSDNIRLYTDEAEDEVKELHVIATISEYFPPRTEEEMKKAPKLSFDKTQHDFGSVNKGVTAITDFKITNNGMEDLEIRSVKPNCGCTVARLKKQTIAPGETVSFEVRFDTSGRQGRQYKTVTVFSNDPSAPSQMISIKADVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU6</accession>
    <name>A0A654DUU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="31" mass="3611" checksum="0263C5B0C93924F0" modified="2020-04-22" version="1">MPEDFFTTFNMNAKKEHFPMNVAVMPRIGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW1</accession>
    <name>A0A654DUW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="44"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="418" mass="46134" checksum="F242BACE724CCC28" modified="2020-04-22" version="1">MDLFEKLLQDRGPLGQHSYFDDNFYMFPKLEGEIAPRMKFRGKEVLTWSLNNYLGLANHPEVRKADAEAAAEWGMAYPMGARMMTGNTVYHEQLERELAAFVQKDSAMLLNFGYQGVMSVIDALVDRKDVIVYDAESHACIIDGLRLHMGKRFVYPHNDIENLEKQLKRAERLVGETGGGILVITEGVFGMSGNMGDLASIVKLKEKFNFRLLVDDAHGFGTMGATGAGAGEEQGVQDGIDIYFSTFAKSMASIGAFIAGDAAIIDVLKYNVRSQIFAKSLPMPLVIGNLKRLELLRTKPELKENLWTIVNAIQSGFREKGYRIGTTQSPVTPVVMNGDTMEAVNLVKDLRMEHSIFCSVVVYPVVPKGTIILRIIPTAVHSLDDVAETITAFEAVKKKLDDGVYKKAGVEGATLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY9</accession>
    <name>A0A654DUY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024793053" evidence="1">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="367" mass="42225" checksum="1C3C15ED6064DBA4" modified="2020-04-22" version="1">MRIYLLFLFLIIQFCGNAQGDFVETKNGHYLEGYVLHKAETRFGIKYKAREDDQWEIIETENLTSFSMRGDTYLVLNHPVDNLPLYFKILAEGEWTLLQEVKEKALFIKMPETFQEINPDNFKSLVTQYTTGYPEEEIKKLEFSKSSLTKLTKAQNTHSQFVRRREIGFSLALSASEASFGQGIYDGNFKRFSERAVGWRAGFNMESYLFNSNSFSIDNLLTIGSITYDYQQTTGDLYHPNTRPDIYVRRKEGSVKMTDMNVQSVAKLYHAAPRFNPFIQAGISMTCFVNKKAQTNFSYQSPDRQWSETRTESLQASSILLNHVLGFGFKVYGKDGNSINLSYDRTQSFSSERITVSTSSISLILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV49</accession>
    <name>A0A654DV49_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine dehydratase</fullName>
            <ecNumber evidence="8">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdaAB</name>
        <name evidence="10" type="ORF">MARINOS108_10888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="9">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="24680" checksum="A6393C53800525FC" modified="2020-04-22" version="1">MSERSSVFDMIGPVMIGPSSSHTAGVVRIGRVARKILKDKPTKAIITFYNSFARTYEGHGSNRAILAGLMDFPTDDERIKGALELAKDAGIEYKFKSIGNASTLHPNTVRLNLTSKDNQAEVVGESRGGGVIRIREVNGFDCNFTASAHTLIIHADDQKGSIAFISDVLSHDDCNIATMTVSRKGKNDLACLVFEMDSGIKTITLEYLRNLNWVRSVLYIPDIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD1</accession>
    <name>A0A654DVD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="SSF49562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13128" checksum="EB6993356D6993A9" modified="2020-04-22" version="1">MTKILLTKLQCIVNDEIDEDEVFLKYKGEKIWPDSGLYRGIDTSETFDVNVTIENESPEEPMVVELWDFDFLSANDFLGTFTMKIGSDTEGSFSTSMALKEEGSTASYILYWEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVG7</accession>
    <name>A0A654DVG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Potassium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kefC</name>
        <name evidence="9" type="ORF">MARINOS108_10713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004771">
        <property type="entry name" value="K/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00932">
        <property type="entry name" value="2a37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="8">
        <location>
            <begin position="419"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="626" mass="69133" checksum="0B21B2E4F51E73E4" modified="2020-04-22" version="1">MSGSILFQAIIFLAGAIICVPIAKRFGLSSVLGYLLAGILIGPYVLGFVGEEGEDILHFAEFGVVIMLFLIGLEIEPKSFWKMRKTIVGMGGSQMAITLLLFYLAFLTMGFSWQVSLVISMAVVLSSTAIVLQTIKEKGLMDTSFGSSAFSVLLFQDIIVIPMLAIIPLLTNSAPTEVAGGHEGESHTYILENLPLGIQTLGVFLSVVLVVVAGRYLIVPVLRLVATTRLRELLTASALLIVLGLAFTMELVGLSPALGAFLGGVVLATSEFKHELESDLEPFKGLLLGLFFMAVGASINFIVIGDNPLMISGLVFGVIVLKAIVLFLVGTFFKMKMDQKLLLSIGLAQIGEFAFVLLSFAFQLNILDRVDLDMMLVVTALSMTLAPILGIVNERFILPKVGTRQSEPRKMDHIAKTHKIILIGFGHFGSTIGRFLRSYGIEATILDHDSNRVDILRKMGFEVYYGDATRIELLESAGIAEAELLICAIDNPDANISLAGLIREKYPHVKLMMRAKSRMDASELLNMGISNVYRESLETSVRLASDVLHHMGFRRYTVHRQAQNFIKYDEESLRRLATEPMNSDQYVFKVREEMEQQEKLLEEDLKRGIVDNDHQWDSARIRKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS9</accession>
    <name>A0A654DVS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="3">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bioF</name>
        <name evidence="3" type="ORF">MARINOS108_11159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.47" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="368" mass="40774" checksum="627083FC51825605" modified="2020-04-22" version="1">MTLDFLQEKLQDRIEKGNIRTLGGKAGLVDFVSNDYLGLSQNQELAKRIRERMDSEGAVPNGGTGSRLLSGNHRFYGAAEQYLQEVFRAESVLIFNSGYAANQALVSAVAEKGDTILYDQLSHVCLKEGAWLSRAETVSFLHNDLNDLEAKIKRAKGRVFVLTETVFSMDGDMAPLADLVEVCEQSNAYLIVDEAHSTGVMGPGGAGYMIQKNLHDRIFGRVYTFGKGMGVHGACVAGSKILTDYLINFGRPFIYTTSLPPHSVLAIEESFRYLSEHLVLQDELEAKINLFRSRWEKSLSHTAIQPVMIGSNKKAREVSMSLQEAGLDVRPILSPTVQRGTERLRISLHVHNTDAEIIRLTDLLSELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV2</accession>
    <name>A0A654DVV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024999549" evidence="1">
        <location>
            <begin position="19"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120157" checksum="7A50654B72E8B33D" modified="2020-04-22" version="1">MTRILIPLLIFSFFICQAQDDWDVTSPVAPFQETTITVEEGTWMNLDVSPDGKTIVFDLLGDIYSMPISGGNATPLRTGHAYEVQPRYSPDGKKISFTSDAGGGDNIWVMDADGQNATQITREDFRLLNNAVWTPDGQYLIARKHFTSQRSLGAGEMWLYHITGGSGIQLTTRKNDQQDAGEPWVSGNYLYYSEDVYPGGYFQYNKDPNSQIYVIKRYDRTTGKTETVIGGPGGAVRPQISPDGSKLAFVRRVRTKSVLYIHDLATGIQKPVYDELTKDQQEAWAIFGVYPNFNWLPDNRTIVLYAKGKIRKVNTLTGESTIIPFKASATHRITDAPIFKQNPAPESFRSHVIRNATTSPDGKLLAFNAAGHLYTMKLPNGKPKRLTTSTDFEYEPAFSPDSKSIVYVSWADERKGAIHKIPATGGTPTRLTSEKGIYRTPSFSKDGKTLVFRKDEGDGTLGHAYTVKPGIYTMPVAGGTPTFICEDGENPVFNPKGDRVYLQTGGYLFGSLDKSYKSVNLKGEDEKIHFHSKYANQYTISPDGKWLAFGELYDVFVMPFSDHGQTFELTGSTKALPVTKVAEDAGINLQWSADGKSLQWTLGNKYHAVNVKDCFTFLEGSPDSIGDIPKTTVEIELTLKTDVPTGSIALSGGKVITMNGEEILENGVVLVQGNRIVAVGTQGELEIPADAKIIDVSGKVIMPGLIDTHAHLRAFRYGISPQKEWSYYANLAFGITATHDPSSNSETSMSQSEMVRAGLMVGPRIFSTGTILYGADGDFKAVINKYEDAQSAIARTKAYGTFSVKSYNQPRREQRQMIIKAAHENEIMVYPEGGSTFFHNMTMILDGHTSVEHNIPVAPLYQDVIELWSASKTSNTPTLIVNYGGLNGEYYWYQKTNVWENEKLMKYTPRAIIDSRSRHRTMAPDEEYENGHILVSQSCKALVDAGVKVCVGGHGQLQGLGVHWEMWNLAQGGMTNYEVLRAATLHGAEYIGMGEDLGSIEVGKLADIIILDEDPLADIRNSESVRHTMINGRLYDTNTMNEIGHQPNKRSQFYWEMDSYNDNFPWHEESHSFQGLHCSCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW06</accession>
    <name>A0A654DW06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="27891" checksum="9E9AF0775F6FF895" modified="2020-04-22" version="1">MIEINNIKKSFQGKEILKGINGTFEPGKCNLIIGSSGTGKSVLLKCIVGLFKPDEGDVLYDGRDFSHGDKEAQTEIRREIGMLFQGSALFDSKNVEQNVMFPLNVLTDMSKEEKIERVNFCLQRVGLENVNKKMPSEISGGMKKRVGIARAIVNKPNYLFCDEPNSGLDPQTSMVIDELIDEITQEYQMTTTIVTHDMNSVIEIGQKVMYLYKGEKLWDGTNKDITHSGVKELDDFVFANRMMKEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW66</accession>
    <name>A0A654DW66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21907" checksum="F8BFD04060F6258A" modified="2020-04-22" version="1">MDKAADIPVGNVRVRSMHPKKFAMWLFIITVTMIFVSLSSAYIVKRAEGNWPLIEFPSLFNVTTVLIVLSSVTMQLAYIFAKKNNLFWLRLNLILSGLLASGFVIGQYLSWSQLVSQDVYFVGNPAGSFIYVFTGLHALHLIGGVVFLAIVLVNAFRYKVHSKSLAQIEMCLTYWHYLGGLWLYLYLFLILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG5</accession>
    <name>A0A654DWG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SprB repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025667">
        <property type="entry name" value="SprB_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13573">
        <property type="entry name" value="SprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="27374" checksum="FF02763825D200B8" modified="2020-04-22" version="1">MNDRVLRLLYVLTFLLATSCQWEQMNPKIDCSTSPVVIATLEVQASQCDSPVGSFAVAASGGEPPYTFTSAGKTNVDGIFANMEAGSYIVVATDANDCTDELSVSIENTGGVNLTEVITNNAGCGTTDGSIRVNATGGMEPYSYQINNGEVQIGNTFEGLGLGTYSVAVIDQNGCESAQSVEINSGVSYEASIKSIIENNCAISGCHNGSVSPNLTSFSTIQSRASSIKTKTGNKSMPKGSSLSQQQIDLISCWVNDGALNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL0</accession>
    <name>A0A654DWL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YceI-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="46"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="27130" checksum="39929B883ADD0A3F" modified="2020-04-22" version="1">MNAPTMKLMIGLFTLTLISSCSTPTEKNLEAGAEQEVMSVSEKAAWIDIDTTSSVVTWIGSKPKGQHNGIIPFTTGQLAVLNNEIVGGKFEMAVRRLQVMDLMKDPARSKKLKDHLMSEDFFEADSFPTASFEIVEVTPFDSTALPKDTQEFESEYTPATLSSFMVANPTHLITGNLTLRGATRSITFPADISFNPESIRAEAKFNIDRTDWNLSYSDEASVIDKAKDRFIYNTVNVGLNLEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL5</accession>
    <name>A0A654DWL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6177" checksum="2B08A5D8C04045BB" modified="2020-04-22" version="1">MGHTPEWCSRTGQALKIGQLIITFGATKTDLCQFDNNILICKGILNSYLGVLLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP3</accession>
    <name>A0A654DWP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="29952" checksum="A01BC046A0A89660" modified="2020-04-22" version="1">MEATAPYLSATNHLNLKILISISFLSLLAFNSISQPNTEFLNKAVDAMKVDISNDRFDELAIRGLGKVLDNFDEQDFFGLTSTDSTFIRLIWERSWEKDVLINIYGSENNFELVVKTEGNNTRRIEHFNITELTNKEIRLLKKHLAYGDFNPEIEAIISQSIIADSVKYRYSSTTAQLSEYTAAELIEQLNKSNFYGHDQIDFNHVVADGWSWSLEVLQPGKGFYIVMSDSYSDHPNDNDFSKVCLRMLNLATELNLIEKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY5</accession>
    <name>A0A654DWY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13745" checksum="4F9ED8F5A299DBF2" modified="2020-04-22" version="1">MDKKKTVIIGATPNPTRYAFLAAERLTNHQHPVVPVGIKRGEVFGKEILDLREKPSVDGVDTITLYLNPTHQREWEEYILSLQPKRIIFNPGTENDRLAAKAADQGIETLNACTLVMLSASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX12</accession>
    <name>A0A654DX12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IX secretion system PorP/SprF family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815648" evidence="1">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="36854" checksum="B8A7BB8EB87F3010" modified="2020-04-22" version="1">MKKLLLTALLGGAMTCLQAQDVRFTQFYQAPVYLNPAFTGASGAARAGINYRKQGNSEEAAYTTFSAYADYYFKDFYASAGLLFISDEDAYSGYISQTVAVPLSYDFSINKKVTVKPALQASYTRQGIDFSKFLFSDQIDSDGNVSGGGTSEPLAVNDRISFFDVSAGVLTYGANWWFGYSMHNMLENNISFVEGGNATLPIRYSVHGGVSVSLAEKGRKSRSKLRRFVMPTFNYVAQGGFSQLDAGAILQYEPILFGALYRGIPNPFSEGEYSAVSWIIGVTKFDFSVGYSYDMPLNNRINPGGVHEISISLLFDPSDPNATPRSAKRLKCPIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC0</accession>
    <name>A0A654DXC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="285" mass="32837" checksum="71BBEC3284B75437" modified="2020-04-22" version="1">MWRGSLFFIVLLTCQWACESGENERKGTISALHLDPLLFDRMKESDQVNVVRRHLSLYAHRALDPTAEIAFDERFPDWRQRLPSDLLLQMDTTIYHISCGRLSYLLRDVYRELGFQSATYNFGIEHTPFTHELTLVELSDGLVSVQDAHYNSALFEGDSLGDFFQFLQAVASGGTHDFYFINDTSWANLYLPETYLDTGYEICNPAYVSGPLQPTLNASWYRRDYMVNLQVNLQDSCYGFMTNLNMQRTDGLDFEDLFLTRISSISGYPEWEQRVDTILASAQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH5</accession>
    <name>A0A654DXH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="32697" checksum="FCAC6C8038AFE87D" modified="2020-04-22" version="1">MVHLFNLTNEKVLKIYKTRTCILVEKDEQCYSFHEDWDQFINRDDLFAYANERISVKRPINDAEVLKGELLAPIGRQEIWASGVTYYKSREARMDESKDSGGGDFYDRVYSADRPELFMKAMPYRTAGPGGKVNIRKDSKWNVPEPELTLLVSSGGKIIGYTAGNDMSSRDIEGENPLYLPQAKCYDQSAAVGPCIYVSEDPMAEDSEIHLEILRGDKQMFHGQIEISQIKRKFEDLVHYLILETSFPSGCYLMTGTGIVPPNEFTLQQGDEIRITIDHIGTLINFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV1</accession>
    <name>A0A654DXV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor guanylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.77" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="20809" checksum="E62ADC6D3E30CBC0" modified="2020-04-22" version="1">MIKCLILTGGGSSRMGEEKYLLEDNGAPQYQHLYEMLTAQGLPVYISCNERQAEVIPDTYNKLVDAYDQIGPIGGLATAIAEDAKSSWLVVACDLMGLTPEAVTGLISANAPEYDIITYQHPESRFYETTLTIYNPGAFIVLKRAIRKEVYSLQDILKKCATKAIEGSAGFLVNVNTREDRDTSRGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX1</accession>
    <name>A0A654DXX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hybrid sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024965256" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="847"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1356" mass="154569" checksum="7A804D5C7219F07A" modified="2020-04-22" version="1">MTKWVVLMTCLAVSGYVASQPSADIKFERITTTNGLSNNQINDVFQDKQGYIWVGTLSGLNRYDGYNVKSFYHEEGKSGTLQNNTILWMARGPEGEMWVRNSLGISVYNSSKETFEVPVAYLTLLQTEPVFIAQMEDDPYGNFWFVVENRGLVKISKDGSTQQFNSNQDGIKIASNTITDIVTDHLGNIWVVHSIGAIEMIDPRENKVIRRYGIPEISSKKENYWRLFVDMDQDVWLFSTDDPFGLFYLNTRTGETRLLDEKILTSELIRDVIQYEDNQMWIGTDHGGISVLVKDTWSVRSVLNDPDAPKSLNNNNVNTLFRDRDGGVWVGTTKSGINYHHRGANNFAHYKVHKKDPAYNDMSSMVEDRSGNLWIGTNGKGLLYFNRANHTFQSVLDDMSIPGPTPAVVVSLLYAKNETLWVGSYLEGLFLYDGKRFSRFNFGNDDPESGSSVWELYEDSQGNIWIGTLNRGAYRLNPKTNELTNFSIQNELKANYVTCITEDPQGRIWLGTGRGLSVFDPRDESVRSFLSEDTIQYPISNNSIISLHSDRDGQLWVGTLDGLNRYDEDKNGFKVFRDSDGLSSNIVMSIEESNNGDLWMSTSRGITRMSTGLKPYDFQTFDLSDGLQGDSFTEDASLKTRDGDLIFSGQNGFNVFRPSEIEVSDKAAKTLFTKFFISSTEITTGAAFHDRVILTNPLDDTRDIYLNHDENTISIEFVALSFFQSSKLRYQYKLEGFDDDWLNAPPEVRSAKYTNLDFGNYTFRVRSSNNPNTWAGEDIFINIHIRPPFWQTPWAFGLYFSMIILALYLTRTYIVHRERQKAQVENERKEIERQHQLDMMKIKFFTNISHEFRTPLSLVLTPIDRMIKNPEKIKVGDLTIVQRNAKRLMTLVNQLLDFRKMEANQHVLSQSSGNIVAFLQDVIDSFSDLSREKEITLNFESEVRSFYTFFDKDKMEKVMFNLLSNAFKFTLPGGVITLDFELQKKAEGSSNAVIMVSDTGIGIPEDKQQLIFNRFFQNEITGDIINNGTGIGLSITKEFVELHGGRVYVESKLNMGSTFVVEMPLRELSTDEDIADELVRELAGSVHKREETIEPGNELKPSVLLVEDNFDFRFYLKDNLKQHYNITVASNGKEAWKMMMHQLPDIVISDVMMPVMDGHQLCEKIKSDPRTLQIPVILLTAQSSDQHRIQGLDAGAIEYISKPFNFEILVSSINSALKFQRRVQESGSRIKATPAEVDIVSMDEKLIAKAVNLVEENMSNSDFSVEDLSHELGYSRGHFYQKILKITGQTPIDFIRNIRMKRAADLLGRSQLNVSEVAYKVGYNNPKLFSRYFKSQYKIYPSEYRSKAVDPESPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY0</accession>
    <name>A0A654DXY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tnpA</name>
        <name evidence="3" type="ORF">MARINOS108_11224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Y1_Tnp" evidence="2">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="18576" checksum="01B95E47DBC30C72" modified="2020-04-22" version="1">MIDSLVLLNLLMANTYTQLYVHVVFAVKGRQNMISPKWKEELYKYITGIVTNQGQKLMIINGMPDHLHILIGMKPDIALSDLVRDIKSNSSKFINEKGLTIGKFAWQNGFGAFTVGQSQKENVINYIKTQEEHHGHKTFREEYLGFLQAYQIAYNDQYVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA0</accession>
    <name>A0A654DYA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="Royal_jelly/protein_yellow"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="505" mass="56018" checksum="79A23E59C8CEB6C6" modified="2020-04-22" version="1">MKTNQFIILLILCLSIINQVVGQNGSLEIVAELPIRPGDVAVSKSGRVFATIHSLGSRNLQLIEIKSKKRFEPFPAKSLQKNENPANDQMLDSPLGLIFDKEDKLWVIDMGQELGKTRLWCFDIDQRKVLRKIELPESVAPKGSFIQDVAIDHEHQWAYMADINNPGIIAMDLATENTRRLGGAKELEAEDVDMVIDGELVYFGGKPARVAVDPITISPDGNTVFFGAMNGTNWYSLDAQLFRDGASDESIQSSIVRVGEKPISDGASSDGMGNHYFTNLTAHAITRLNPDGTLEHIIQDDQLKWPDNAYLAPDGSFYISVNQLNTTPAFTGGEDDGKPPYYIYRFKPQSHNDIPIPDRVSIDGGLSTKEANKLKETALYFYAFWNTGKQEYLDRSISEKFMDRTLPEGRPQGPGGPSFASDAFRKAVPDLKCEVKDLLITKDKVTIRMVFSGTHLGAFAGVAPSGKPIEFNAIDILRIEDGKIVENWHLEDNLSLFQQLGVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA3</accession>
    <name>A0A654DYA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17391" checksum="A5A7B7D175836BBC" modified="2020-04-22" version="1">MIEEIHNYYTAEKAGVPYVVLAGILLVGAGILILFKASAHPISKGIATGFLISGGLLIVIILSNKYYNDMMIKELPNRIDETELELQQSEIGRMEKVMNFFSLCFLGVCLFHHNIGMVDGSYTELFLERIFYRTLVFSVADINSRYLQFKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB7</accession>
    <name>A0A654DYB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19405" checksum="74E9C115100FEA66" modified="2020-04-22" version="1">MRYLNFITIIWLMNSCGNPNSRNINEETPVDTVKVEQITPTEPTREFDTITEQEIEEELVTDVEPLTFDSAGRPSRPILRNLQVDTSLLFGVWANEHSAPNAAFLIDKDKYYIADFDGDPYVPYILEGDSLTLFFEWGEQTSRISLPTPDLLIMSSRDGLTSQYERFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF0</accession>
    <name>A0A654DYF0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">agaA</name>
        <name evidence="7" type="ORF">MARINOS108_11730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Melibiase_C" evidence="6">
        <location>
            <begin position="312"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="400" mass="45246" checksum="36D67615B0557700" modified="2020-04-22" version="1">MKTTLSIIFTLSVFLAGAQKFDGLALTPPMGWNSWNKFSCDVTESLIRETADAMVASGLKDAGYEYIVIDDCWHGERDSLGFIQPDPVRFPSGIKALADYIHSKGLKFGIYSDAGWQTCGGRPGSRGREYQDAQRYASWGVDYLKYDWCNTEGLKAEGAYLTMRDALYEAGRPIVLSICEWGDNQPWEWAGPIGHLWRTTGDIYNCFDCEYNHGTWSSWGVLQILDMRKDIRKYAGPDHWNDPDMMEIGNGMTVNEDRAHFSLWAMMAAPLIAGNDLRNMSPETIAILTNKEVIAIDQDTLGIQAFKHIDDENFEVWVKPLAKGDLAVCFLNRAVEPLDLNFDWKSNPMKDPDFDYTFDFTRNTYDLLNVWSGKQQGTTKKVLKASIPGHDVLMFRLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ4</accession>
    <name>A0A654DYZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fucP</name>
        <name evidence="2" type="ORF">MARINOS108_11931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015535">
        <property type="term" value="F:fucose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005275">
        <property type="entry name" value="Lfuc_symporter_FucP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00885">
        <property type="entry name" value="fucP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="433" mass="47313" checksum="2570D8FCE15C6F57" modified="2020-04-22" version="1">MMKNIPVVSRSIVFPFILITSLFALWGFANAVTDPMVTAFKKVLELDNFQASLVQLAFYGGYFTMALPAALFIRKYSYKVGILIGLSLYATGALLFYPAAISESFTFFLLGLYILTFGLAFLETTANPYILSMGDSSTATQRLNLAQAFNPLGLIGGLVVAQQFVLKKLKSDDVVFSELPELEKAAITTADLMVIRDPYVVLGLSVIAVLVLIVVNKMPKGKGEEMHSPLSKVFKSLMKKPVYIEGVITQAFYVGAQIMCWTYIYQYAEAIGLPADEAGTYQFFAFISFFIGRFICTFLLKYVDSGKLLMGLSLMAVVFTLGTIFITGMPGLYCLVAISFCMSLMFPTIYGVALEGLTEDESKIGAAGLVMAIVGGALMPTLQGMVLDLGGTGYADLKILGVSEVNFSFVLPLLCFFIIAFYGRRVAVKHQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ37</accession>
    <name>A0A654DZ37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfuration protein SufE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="2">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="16017" checksum="117B441AE42E5367" modified="2020-04-22" version="1">MSIAEKEQEIVEEFSMLDGDMEMTINYIMELGERLPEMPADKKNDDHIVKGCQSKVWLAATANEAGQVIFQADSNTAVTKGLVSLLVRVLSEEAPEAILNTEITFPQQIGMNRFIGTQRSNGFGAMIKQMKLYALALSSKTQTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ3</accession>
    <name>A0A654DZJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18892" checksum="D9672D1344E6A32A" modified="2020-04-22" version="1">MYVIFLLLFSFCSFLIFWQDFKSRSIHVYLILFFAVLPVLFHFFVQPISLWGLAFNWGFLAVIIGLSMLLIRWRNQLSFSGMFGLGDVFYLMIVSVYFDFPDFVIWLNAGLISALSMHLMANRLSERYKKQHLIPLAGFLAPIFTVALFIHIYVGPVSAYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM2</accession>
    <name>A0A654DZM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="81" mass="9374" checksum="AA94E02EB4CD098A" modified="2020-04-22" version="1">MPDDLISCTLKVSTKLLNLINISFPLAFETEAYSYPSHLVSYKLTTYFRLKLRCAKLKPGRELIHFRSNDESILQLIFGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E013</accession>
    <name>A0A654E013_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">MARINOS108_120229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD16454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="20983" checksum="1F1AD571F1419D18" modified="2020-04-22" version="1">MATTADFRNGLVIEFNHDLFTIIEFQHVKPGKGPAFVRTKLKSLSTGRVIDNTFTSGHKVTTARVERRAYQFLYKDDMGFHFMDSTTFEQLPISDSLINAPALLKDGQEVDVLFHAEEERVLGVELPQHVILKVVYTEPGLKGDTATNTTKPAELETGATIQVPLFVNQDEVIKVNTQTNSYVERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E019</accession>
    <name>A0A654E019_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_11168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="12">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD12791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="31258" checksum="75BA19DEB423A1B2" modified="2020-04-22" version="1">MENADFKHFGKLRSKLFVIVFGTDTPAGKAFDLVLLVAIVLSIIVVMLESVRDIKIRFEEIFYILEWTFTIIFSIEYLLRIFISKKPKTYVFSFFGAIDLIALLPTYISLFVTGGSYLVVIRAIRLLRVFRIMKLTRYINEARMLGQAMEGAKRKILIFMGAVFTLVMITGTLMYLIEGGENGFTSIPRSIYWAVVTVTTVGYGDIAPHTVLGQTFATILMLTGYAILAVPTGIMTSEINKAERRGSIKDKICQRCTTGNERQSNYCSKCGERLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F3</accession>
    <name>A0A654E0F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024902217" evidence="1">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="26555" checksum="398E5F59150044D9" modified="2020-04-22" version="1">MKKYLLVSLLPLFAASLYAQYQEPQKEDHPLTANRLILKGDFANAVNPKDPSVLLSLEYQFRTWVSFTQEVGVVAEVRSEESVGDEYLGFKAREELRFYYQPGSSEEALWYFSVNAMYRYLKVDEPVTVGYGCTSDWTGSCDYLRFYDEETSSHRYGGGFRMGISKSVSPRLTLEGDIGLNMMYLLLNRRQEENVTYFFRDDFFFNNERGLRLQPTLSAKVGYVLMKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F5</accession>
    <name>A0A654E0F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">menG</name>
        <name evidence="5" type="ORF">MARINOS108_120317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="27066" checksum="E6E2FC20BBE05B8B" modified="2020-04-22" version="1">MSVVPYKDKQGSKKEQVATMFDNISGNYDFLNHFLSLGIDIAWRKKAIRQLKDLQPKQILDIATGTGDFAIEALALKPDKVTGVDISEGMLAVGRQKMKKKGLDQKIELLSGDSEALQFEDNKFDAVIVSFGVRNFEHLEKGLADMYRVLKPGGRTVILEFSKPKSFPFKQLYHFYFKWILPKIGNTISKDQAAYTYLPESVRAFPDGQNFLEILEKVGFKNTQCKPLTLGISSIYIGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K9</accession>
    <name>A0A654E0K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19645" checksum="69C9CEB067532193" modified="2020-04-22" version="1">MADQTWSTFRRKIYINAPSGKIYWHWATSKGMETWFLRSCEYTDNREVKRAREEHAQAGDTYLWYWHNWADGETGIINEADGRTHLAFSFSGAQVTIDLEESKGVTLVTLTQHHIPTDDRSKMNVYYGCGTGWTFWLANLKAYLEHDVLLHHTAPDMMGRSDFSDFVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M4</accession>
    <name>A0A654E0M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ORF">MARINOS108_120204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="18023" checksum="621FFF2204AF4BCB" modified="2020-04-22" version="1">MAKDTSRFSNNISIKNRKASYEYEFIDKYEAGIVLKGTEIKSIREGKASVQEAYCYLKNDEVFIKSMNISPYSNSSFANHEITRDRKLLLKKKEVEKIKTKTEEKGLTIVPTKMYINSRGFAKVEIAVARGKKLFDKRDSIKKKDQDRELKRLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q7</accession>
    <name>A0A654E0Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase IV</fullName>
            <shortName evidence="12">Pol IV</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">dinB</name>
        <name evidence="14" type="ORF">MARINOS108_11418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="12">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="42988" checksum="4F5BECD74B9C63F6" modified="2020-04-22" version="1">MVKNESQYIVYRKGYHTLIALENHPIRKIIHIDMDAFFASVEQHDHPELKGKPIAVGGNKERGVVAAASYEARKYGVKSAMPSAIAARQCPHLIFVKPRFERYQEISLQIRNVFQEYTDLIEPLSLDEAYLDVTENKPGLTSATVIAREIKAKIKERTGLTASAGISYCKFLAKTASDVNKPDGLFVILPEEADEYLKKMPIHRFFGIGKATAEKMKTAGIFTGGDLRKKTFADLTLRYGKSGSYYYNISRGIDQRPVKPDRERKSVSAEHTFEHNLMRIAEVKTELDQIAAVTFERYSKHGTHGRTVTIKVKYGDFKQITRSISLEENVTDLEQLSRAVHQLTDQSLIREEGIRLLGVGISNFQKMTEEDSPIQLTLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S3</accession>
    <name>A0A654E0S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Effector-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AraC_E_bind" evidence="2">
        <location>
            <begin position="180"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="37210" checksum="7863E607FA9EA601" modified="2020-04-22" version="1">MKAIKIVGIILMILATVVLITIYLLPDNAHMERKILIESQPEAVYTELISFRTFNEWSPWATKDPMAEYLWDGPVIGVGARISWKSTVVGNGSMQIVEVMENRKVVNLMKFDEYESDPTAAFILNPVAGGTEVVWTYDEFDVQGLAKIFMLGIDGFLGEDYEQGLLALKERVESAPDFQFPMNLRTIAPFQYLGIRDSTVNDPALVSTMMAQNYGELVTYMSIRGVEATGNPLAVFTDFGYADLSFVCGYPVADPLSGSGRIELFRQEGGPAIVLNCQGGYENLDKGYDQIMEFAAFYNYDLVDNPWEEYITDPETNPDTATWTTNIYYPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T9</accession>
    <name>A0A654E0T9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">accB</name>
        <name evidence="7" type="ORF">MARINOS108_120230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="16602" checksum="06F0851C75A27F5B" modified="2020-04-22" version="1">MKAKEIRDLIDFISGSGLEEVNIETEEFKINVKRSSPQVTVAAAPAPAAPAAPAPAPAPAAASEAPKAAPAAPAPASDAHLITIKSPMIGTFYRSANPESPAFVNVGDAVKQGDPVCIIEAMKLFNEIESEISGKIVKVLVEDAQPVEYDQPLFLVDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V6</accession>
    <name>A0A654E0V6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gmk</name>
        <name evidence="10" type="ORF">MARINOS108_120519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21589" checksum="4680D9984929A217" modified="2020-04-22" version="1">MSRGKAVIFCAPSGAGKTTIVKHLIETIPNLKFSISATTRAKRAGMEEDGKDYYFLSQADFRKKLEAGELYEWQEVYPGVFYGTLKAEVERLWSEGYHVIFDVDVIGGVNLKEALGDRALSVFVNAESVDVLRERLEKRQTETKESLERRVGKAEAEMQYAEKFDYELINRDLKTAFREAEQVVNDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z8</accession>
    <name>A0A654E0Z8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplL</name>
        <name evidence="7" type="ORF">MARINOS108_120507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="12823" checksum="CA98BDDBD56845BF" modified="2020-04-22" version="1">MADLKEFAEQLVNLSVKEVSELATILKDEYGIEPAAAAAPVMVAGGGDGGSAAEEKSSFDVVLKSAGAAKLAVVKLVKELTGLGLKEAKELVDGAPSNVKEGVAKDEAEALKKQLEEAGAEVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z9</accession>
    <name>A0A654E0Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron(III) dicitrate transport protein FecA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="158"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="345"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="819" mass="92202" checksum="652A82A307A92A47" modified="2020-04-22" version="1">MVALRDIWRLGVTLAFLVVACSAMSQRISGVVTNEAEEPMEGVMIFLEGSSLKTTTDAKGYFELSDLGDGDYRIVAFFPEYQTDFLDVKAGAENTTIRFRLKPMSQELESVVVENTRSETMGISWLQSVSGAAIYEAKKTELINVGGLIGNKAANVGRQVYAQVPGLNIWESDGAGINLGIGGRGLNPNRTSNFNVRQNGYDISADALGYPESYYTPPVLALDKIEVVRGAAGLQYGTQFGGMLNFDFKEGPRDKKIELTSAQTLGSFGLFNTFNSLGGTVGKVNYYTFYQYKHSEGWRPNSQQDQHNLFASVTYDFTPFLSAKLEHTHMTYLAQQPGGLTDIEFYQNPQQSKRARNWFDVGWDLTAMEWNYRYSSSLKFNNKTFMLGANRYAVGNLERIDRPDDPTENRNLLKDEYHNWGNEFRTIYHYNLLGQKSVLLVGNRLYFGKTLREQGEGDNGSGPHFEFENKEEPGESDFTFPSRNVAFFAENIFNLTPRLSVTPGIRYEYIRTDAKGYYYDRREDLAGNVIYEEKVEEDKSKPRSFALMGVGISYKYSETVEVYGNFSQNFRAINFNDIRVDNPSLKVDENIDDESGYNLDLGIRGAEAGKFRYDVSLFYLSYQGRIGNVLRTEPDPRFNNLVDRTFRYRTNVADAGILGLESYIEADLLKLFSIPAEKSTVTTFLNFAMISSRYMNNDEAGIEGNKVELVPPINIKSGVTYKRGNFGISYLYTYVMEQYSDASNADSTPPVPTAVEGIIPTYFVMDLSVSYGYKFWTFEGGVNNFTGESYFTRRAAGYPGPGIIPANPRNFYVGVGVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E161</accession>
    <name>A0A654E161_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="38628" checksum="A0CD16F626D32A15" modified="2020-04-22" version="1">MKILILRFSSIGDIVLTTPVIRTLKTQLNEVELHFATKKEYLPVLEENPYLDQIHLLEGGLSPFISQLKKEKFDFIVDLHHNLRTLAIKNQLGVKSFSFNKLNLQKWLYTNLKINKLPNTHLVDRYMDTVATLGVKMDNLGLDYFIADKDEVELNWLPEAYQGGFVAFAIGGKFATKKLPKDRIIELCDRINKPIVLLGGKEDAETGESVERFFQRSEKENEFTEGLEALGKKAIVFNACGKFNLNQSASLIRQSRWVFTHDTGLMHIAAAYKKEIFCIWGSTVPEFGMYPYRTKFTIFENKKLDCRPCSKLGFDKCPKGHFKCMNEVSFDFYLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E162</accession>
    <name>A0A654E162_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="16565" checksum="C09AE153288472E9" modified="2020-04-22" version="1">MQVVVRSGTIEEAIQIQEQIPEFENGYTAAEYTNRLLGGESVILIAEIAGKLAGFKVGYDRFLDGKVFYSWMGGVVPAFRGRGVAKILLQKMEVWCKLKGYRSLKFKARNSHRSMIHFAIHQGFDVVDFEPQPNPDDSKIYFSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E197</accession>
    <name>A0A654E197_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="3">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crt</name>
        <name evidence="3" type="ORF">MARINOS108_20019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="28068" checksum="AF21A5833B724D46" modified="2020-04-22" version="1">MADLQNLSLSTNGSILTVTINRESKLNALNTDTIAELKEVIQSVYDDKDISGVIITGAGEKAFVAGADIGEFSELNEMNARKFSEEGQEVFQLIENCHTPVIALVNGFALGGGCELAMACHMRVATANARFGQPEVNLGILPGYGGTQRLTHLIGKGRAFEYLMTGDMMDANQALSYGLVNYTEVDKEAAMAKANDILEKISSKAPIAIGLVVDCVNAVFNQDENGYQTEANAFARCCGTDDFKEGAAAFMEKRKPEFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W6</accession>
    <name>A0A654E1W6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fadN</name>
        <name evidence="10" type="ORF">MARINOS108_20242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="208"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="799" mass="89350" checksum="F0A4E02BA3959ED8" modified="2020-04-22" version="1">MKRTIKKAVVLGSGIMGSRIACHFANIGLEVLLLDIAPKELTDQEKAKGLTLDSPHVKNRIVNTSLQTAISSKPSPLYHQEKASLITTGNFDDDLSKIKDYDWVLEAVVENLEIKKSLFEKVELYRKPGTLISSNTSGIPINFMLEGRSEDFQKHFCGTHFFNPPRYLKLLEIIPTKKTDPKIVDFFLHYGDLFLGKETVLCKDTPAFIANRIGIYAIMSGMHTIQKMGLTVNEVDKLTGPVIGRAKSATFRTMDVVGLDTAVKVAAGLYEGLPHDESREMFKLPKIVQELYDRKWWGDKTKQGYYKKVVENGNKEILELNLETFEYEQKAKVKLDVLDKTKNEEDLKKRLKIVINEEGREGDFYRATFFDLFRYCTVRIPEVADELYRIDQAVAAGFGWELGPFESWDAMGLKDCVDQMKKKNLAPAPWVDELLAAGHQSFYKYENGKKHYYDIPSKSYKVVPGTEGFIYLDAFKENNVVWENDGATIYDIGDGVLNVEFHTKMNSIGAEVIEGINTAITMAEKDFRGVVVGNEGQNFSAGANLAMLFMFAVDQEFDEIDMMIRQFQNTMTRARFSTVPVVSATSGLALGGGCELSLHCDAIQAHAETYIGLVEVGVGLIPGGGGTKELTLRASDKFMPNDPELNILQEYFMNIATAKVATSAHEARAMDILTAADRITLNRARLLADAKERVLELADAGYTQPKERTDIKVHGRTSMAMFEAGITGMKYGAYISEHDAKIAKKLAWVMSGGDLSAPTLVSEKYLLDLEREAFLSLCGEQKTLERIQSILFKGKPLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W7</accession>
    <name>A0A654E1W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="8599" checksum="E6BB495554606CDC" modified="2020-04-22" version="1">MPMSFCRMLYSLLYETAEIKKKINVITLTTVVKIPVPLDFVHPDNPMIVKSEKTPTIYPKNPIILGVFNPLSAIAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z4</accession>
    <name>A0A654E1Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="32412" checksum="C58645208ED9CB3D" modified="2020-04-22" version="1">MAKILITGGSGLVGTHLSKMLKNAGNEVAHLSRSTDSSGEFPSFTWNLAKRFIEEEAFIGVDHIIHLAGAGVADKRWTNDRKKVILESRIGGIKLLHEYVSRLGVQLKSFISASAIGYYGSDTGSAVVTETSPPGDDFLAQVVKAWEAEADTFAEMTTVSKVRVGVVLSDKGGAMTEILKPIRYFVGAPLGTGKQWMSWIHIDDLCRIFQFVMEKELAGTYNATAPNPVTNEALTKLLAKSINKPLFLPNVPAVMMKLLLGEMSQIVLGGSNVSSAQIQEHGFKFSFTQIDHAIDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E245</accession>
    <name>A0A654E245_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound lytic murein transglycosylase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="374"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="508"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="578"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="636"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="682" mass="76362" checksum="D3690264641F3BB8" modified="2020-04-22" version="1">MRIVLLGLLLSIHTFSFGHVGGVPVVPASIEIAGIKLKLTPDAREEIQKDVNALRASEKYFQIKLDRVNLYFPIIERVLKEEGVPDEIKYLSIQESALISDAVSSADAVGYWQFKDFTAREVGLRVDSKIDERKNIVSATRGAAKYFKRNNFYFKNWIYAVSAYQAGAAGAKKYVDKENFGSDKLTITSKTHWYVLRFIAHVIAFQDEVGDPHSEGLRLLEHDKGAGKTLDQIANEFKADQAIVTDYNKWLSHGKIPDDKVYTVIIPIKGKAPKGLEKESDQRPLTRSIEAIEPVKYPDQIASGITKNQKAIFFKVNGLEAVMAGAEDNIVSLALKCGISSTQLIKNNDLNPGEEVRSGEIYYVSSKRNRSAIRFHVAQYGESLWDISQKYGVKLKKLAQKNRMGMADSVKPGRLIWLRKTRPEHTSVEYHEVRKPEPIQKAKPKPVVVKEEVKENPPEEKVVPETEKPEKKPVVEEKVVSKAPETSTNKETSINKSATYTPPSGDRLIHVVQPGETLWGISRLYEVSVSDINTWNNLGAGLPLSLGQELLIYNPVRDKSPVVEEKPTEEAKPKSTADFHEVEPGESLWGISRKYNLTVEELRSWNGLTAESTINAGQKLLIKPLEKERAPSEPFIIHVVKGGDSLYKIANTYGMTVQELMELNSMKSTAISVGDELKVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E283</accession>
    <name>A0A654E283_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="35524" checksum="CABCDD655C9BD3DF" modified="2020-04-22" version="1">MIAILTLLTFSASAQFDQYQSLQTPFGARNAALGGKVVSLADGDLMQFVHNPAVLDSVALTDVAINFSPMFAGVYSFSGAYAAEFSKVGRLAFGVNYLDYGDFVETDPDGTVTGSFQAQDLVLTVGKSHRIGSFALGGNIKYASNGIAGYGSSLLLGDLGGVYRAPDTDFTVGLVFRNFGFVLADYTGSGANQVPFDVQISTSVKPTYMPFRFSISAYNLVQNSMYFSLDEGISKSKTIEIADRIFRHVNVGAEFIIHQNVQFLFGYSHLMHQELKVGEEAYGAGLSYGLALGIRQFQIRYSHATYHAAGGTDFFTIQSNLNSFKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C4</accession>
    <name>A0A654E2C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024830699" evidence="2">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="118" mass="13336" checksum="8DC315C1F4997695" modified="2020-04-22" version="1">MDISYFYLNFHVLKKLASISLTVFCMLLADYASASTNEEASKTKKSTEATSTNNAAEKSEETTSASESTNTGGGMYLNQNQDSTNLNSVCKFNFIFYFIYKLKYDEEPPGNEYLNYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I3</accession>
    <name>A0A654E2I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplC</name>
        <name evidence="8" type="ORF">MARINOS108_120498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="22900" checksum="BCE1B72528BA9C6B" modified="2020-04-22" version="1">MPGIIGRKIGMTSVYNEEGKNLACTLIEAGPCVVTQVKDKESDGYRAVQLAYGERKEKNTPKALKGHFAKAKTTPKSKLFEFRDFRAEFDDKVKLGNTIKIEDVFVEQDFVDVVGTSKGKGFQGVVKRHGFGGVGQATHGQHNRLRAPGSIGACSFPSRVFKGLKMAGRTGGDRVKVMNLKVVKIYPEKNLVLVSGPVPGAKNSYLILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V1</accession>
    <name>A0A654E2V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="11991" checksum="ADF9A34CC37F8CB1" modified="2020-04-22" version="1">MRMITLSFLFTILGFWACYQTSRRVAVAALNRRSESGRPNLTRGLPFGLIGLLVGFVLCVLSYGLGSGLFVFLILLTIVSSLIILLAPLGYISGKNIAVVTLLSALIEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X1</accession>
    <name>A0A654E2X1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024890663" description="CHAT domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="4">
        <location>
            <begin position="697"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119721" checksum="19E2040BE763FD52" modified="2020-04-22" version="1">MTRLYIFALLVLTSFGSALAQYQFENKKAEKLYEKLELYYAEGDYEGILKNEGQIKELFLSKQDTLGALMNGFLGEAYLYWENDLNKSLGFYQKEYELRSALGKEGGDIKNLIFNLGYIQDELGFYGKTESLYLELLQLEEAASGVKSEDYFISATSLLDHYVFTEEFNKGLDLIKDLKKNVDRKSFEEAMLLKFTGDFYQMSGANRKSEKALLESLEILKENGLYASVEYVSVLNSMGGLYTIIGKIPVAEEVYQEALSIMDRLQGDYSDYELALKGNLALILQLLGNYDEAEEIYLENLTADEEFYGTESFVYGMEAYNLASNYMYAQKYAKAEKYFMIAADVFKADMGQENLYYARVLQNLTYLYTQTRQLDKAKENGLKAIDLVEKAAGDNLYQISFAYYNLGDAYFTDGNIPLAEKYHAQALELRKKGVGTGHSDYAKSTNKMAILNWNKNKLDVALGFYKETFKNYFDQINMIFPILSEDEKSKFYYNNLKPAFEQYNSFIVETSREEKELISEMYNYQLATKGLILYATNKVKDAIVNSNDPALISKYEMWIEQKEQLAKLFSASEIPANVRNQKIDSLNASSNALEKELSKASSVFAQTVASRNLTWKDIQTKLKPGEAAVEVIRFRDFTPDSAGVFTDEVYYAALIITDQTKDYPEMVLMRNGKLMETKYLSNYRNAIKYKIDEDFSYKLFWRPIANKLEGIKKVYFSPDGVFNQISIYTLRNPATGNFTLDELEIQLVTNTKDLVALNASPNSENKSYLFGYPNYNMGVLDSKKEEGGSAAKGIVDAASEGRGMSRGVRGSRGADDTDIASLSRGGSLPRGIRGNMLRYMRSNQMLALLPGTKKEVNLIDSLYQLKNASVTTYLSNDALEDSIKNMKSPRTLHIATHGFFLESEEEEMEGQDKYVQNPLLRSGLILAGANSYISEGKISDEVYHHEDGILTAFEAMNLNLDQTELVVLSACETGLGEIKNGEGVYGLQRAFQVAGADAIIMSMWTVDDDATQELMTIFYEEWLGGKTKQEAFIIAQKRLKAKWKSPYYWGAFVMVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E332</accession>
    <name>A0A654E332_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="24587" checksum="4767DAACCD1771DC" modified="2020-04-22" version="1">MVVVSRLLECIGYTMKTIPLFLFICWILALIAYFISVLGLIRTKNQKTFNTYFLNQIDQLLYLLILGLPGAMIISMFLMGTGNMVSMTLLLFTGLICLLPAWIGLRMRLRLLEINKHSSINFNDNWSQFELINDKESEIFPNSTETHAMYFHFNNPRTPWGQYGILILTSNSRRPVSTMLFDFPRYEKQLRITVERKSVRLKEFNSLLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E341</accession>
    <name>A0A654E341_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21997" checksum="2C348815A0F87DEF" modified="2020-04-22" version="1">MKKLIYLIIVASVLVACDTVSKEKRPLVASINKKVGDIDANHRVRIIEDDFHSGDSIYKIRGYFMDESLLKLVGILHTSHVDRDDYFYFENNTPIFSGHLVVEKDGHMAYEYKYYYGADGNVEEALFWEDHYEVGKRFPHEHFEEFSPDLDSLKDSEESRLYFFLSNLDMAGFEIKHLNENLDANVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E389</accession>
    <name>A0A654E389_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized ABC transporter ATP-binding protein YhaQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhaQ</name>
        <name evidence="6" type="ORF">MARINOS108_20044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="303" mass="33491" checksum="7C272C7D642E1B7A" modified="2020-04-22" version="1">MELLRVENISKSYSSHQALSNVSISIPKGSIFGLLGPNGAGKTTLIRIITRIIEQDSGEVYLGGEKITPELVRKIGYLPEERGLYKKMKVGEQLLYLARLKGLSKADATTKIKAWLKRLELTGWSGKTIEDLSKGMAQKVQFIATVMHEPELIILDEPFSGFDPVNANLIKDEIFRLREAGATVIFSTHRMESVEELCDHIALINKSEKILDGLKLDIKNDHKDGTYIVTHEGPLASTDHYDLLSTGTTEDGLTESILKDKTEGGPNNLLKVLIGAVEIHSFIEKIPSINEIFISKVKGDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B3</accession>
    <name>A0A654E3B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024823906" evidence="1">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="268" mass="30361" checksum="34B7EE2A8F622187" modified="2020-04-22" version="1">MIGKIFLLLVCLSILTACYDSDQNSMANCERNFFDPKRTSAQVLDNEHMVLKRVINPDTTFFYLEWLDANDQLSLLIFHPGHKNFLGAESLSHYYVSGDIKASCPSDPSINGVPTQFIDIFNAEKISHCVVNAKQPDDRPLTITYWRFLGFRTPEGILSPTCEENFLYLVFTTSQVNPVNPDDRYFAEIYNGVNDCVYIYRLLSGSLGIITRSFCYREELAPTTSSEKYGNRYMQGLLDPDAIHISHSGSTLVISPENMTDEMIFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S4</accession>
    <name>A0A654E3S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="478" mass="54196" checksum="D1D9BBEDFE6C6930" modified="2020-04-22" version="1">MNSTKGIISKGVFYTALSRYSNVLITILITAILARLLTPFEFGVVAVVMVFTTFFNVLGDFGIGPAVIQFKNLTEKDLQSIFSFSVIVSIALASIFFLSNHLVASFYEDEKLKDIIKLLSISVLFFSMSVVPKALLFKKLKFKQVGILNVAIQLCSGTVAIILAYFEYSYFSLIVKSILDGLLSFIIFFSLSFVKPTLRIKWISIEKIIGFSSYQFMFNFINYFSRNTDNLLISKYFGPALLGYYDKAYRLMMMPVQNLTHVITPTLQPILSEFQDDHDKIFVSYLKVVKVLALIGFPLSFFLFYSSTEIVYIIFGSQWDASVPIFKLLALTVGLQMVLSSSGAIFQSIDRTDLLFVSGLISSFFMVSGICYGIFLGRSLEHVGLGLIFAFGLNFIQSFYFLIVRGLKKPLIKFFKILMVPIGTSCILGLVLCFVSYYRRDNMFLNLLINLIVFLILFLISQEHRKIFSDLIRDFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E401</accession>
    <name>A0A654E401_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="28962" checksum="8C3C0C933692934F" modified="2020-04-22" version="1">MVKVLGIALYDRDISTAIGQILSEQERDNKCLSATGAHGLVYSRKKPQFRSILESFHLNLPDGMPGVWVGRMKGAKRMQRCYGPDFFKEVMIASTASKGISHFFCGGKEGVANRLKEVCEIKFGNHNVVGTFCPPFKPVSEYNYQEIAKIITESKADIVWIGLSTPKQEQFAYHLSKFTEVKFIICVGAAFDFHIGNVRQSPSWIQKLGMEWCFRLFMEPKRLWKRYFEIVPLFIYYNFAEFVTGKFYKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E474</accession>
    <name>A0A654E474_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">MARINOS108_20656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="626" mass="71502" checksum="122E3D371CFFE7A2" modified="2020-04-22" version="1">MCGITGIFAFNSVGRINLVHLEAATRRLEKRGPDVHNTWFDEVAGLGHRRLSIIDTSAAGNQPMTDASGRYHIVFNGEIYNYKHLRTELQNEGCVFHSDSDTEVLLQAYIRWGQEVLPRLNGFFTFAIYDQKEELLFLARDRLGIKPLVYHVDGDRLLFASELKALMAYGLDKQINREALHLFFQLTYIPAPLSILEGVKKLLPGHYMVVQHGAVEIKKFYEFPYQESPPIRGLAEAKQQLITTLRKAVTDRLVADVPLGAFLSGGIDSSVIVALASEEVKDLKTYSIGFKDNKYFDETHYAQLVADKFQTDHHVFSLTNDDLLAEVQNVVDYIDEPFGDSSALPVFILSKETRKHVTVALSGDGADEIFSGYNKHSAWLMSQQTSARNSLIASLGGLWEKLPKSRNHKVTDTIRQLHRFASAQKMTLRERYWFLASFTDDLQIGRLLKSDYQTDHMSFKNNLLQLMRVGELNEVLALDSQLVLQGDMLPKVDMMSMANGLEVRVPFLDPAVVELAFSMHTDLKATSTGRKIVLREAFREVLPEELYQRPKHGFEVPLLDWFKGALKGELEKKVFNREKIEAQAIFDWNEIARIKKKLYSFDPGDTHILVWCLFVFQNWHDRYFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G7</accession>
    <name>A0A654E4G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038396">
        <property type="entry name" value="SpoIIAA-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="14262" checksum="8DEFAC1B11B790E5" modified="2020-04-22" version="1">MIFTSQNIDIKSNSSFGPHCLHFVFKGKFTEQASLESTEAWKAHTRQFPSEKFTMVWDCLKMDGFELSARREWVACMQSEKGQILKVIVISDNIAIRGAAYLMLKLFTFESLVVKSLMELAQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J8</accession>
    <name>A0A654E4J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13543" checksum="23195ED2D50BD0E2" modified="2020-04-22" version="1">MAYFGTLFLLTIVWLWSRILTQLISVELTNKQLNCRNIVTRTERTIELTEIAGFKDGFFNGYTISLIGLTGEPLLTLHEHYYSNFRDFLEQLNLEHLGRRPNLMKRLFGKTEKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K1</accession>
    <name>A0A654E4K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hyaluronan synthase</fullName>
            <ecNumber evidence="2">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaD</name>
        <name evidence="2" type="ORF">MARINOS108_50021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.212" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="36933" checksum="A8080F33139131D6" modified="2020-04-22" version="1">MAKVSILIPVYNTQDFIAESIESILNQTYGDFELVIVDDCSTDDTYSICQRYASSDSRIKLFRNEKNLGMMPNWNYGMSLCTGDYWGKLDADDWWDPEMIEVCVNILDVQPEVGLVCAGHDIINESGETMNDQPLPAPDQFMNQAFSCVDLVKQGPHGFLSYPVMKQGIGLMRRGLIEKVGNFMEFHWGDTEMWFRIGAHSQTYYVDRILHHHRKWSDSDTVKIISQNMDTIYSGLYKTRMQVVNYYFQHGLVSEHELMDFRKITIFEHNKYLISKFRKESSYLHMGKCLFLCLFSFPRRTFLEILHLDRIFFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L3</accession>
    <name>A0A654E4L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="33169" checksum="F80D04612AA262E3" modified="2020-04-22" version="1">MKRLIRYDFVGFLIASRIPNLIVIGATQYLTALFLVSTYPHKNEQIAGLGFFAMVVSTMMIAAGGYIINDYYDQKIDMINRPQKVVVGTMFRRRLAMLAHFLLTLGGIGLGFYLDIKIGVLHIVSSFFLWYYSNYLRRITLIGNVVIAMLTGLTLLVVIVYLQRNEVLVYIYSLFAMAIILIREVLKDIEDVKGDATFGCQSIPVIFGIRGAKLFIYLVCLGSAGLLVSFLITVDIWLVRYYFLGLVPVFLWFIYRLVMADRQKEYNSLVKFTNLIILSGLVSMILIKTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M6</accession>
    <name>A0A654E4M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Four helix bundle sensory module for signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="205" mass="23731" checksum="CEB4A50D9C9BF6E1" modified="2020-04-22" version="1">MEWKFSLGQRIRTGAALLVVFLLVLATNMMDSNHFRIVQSNLTTIYEDRLLAKDYLYKISRQIQAKRELIQRSDIEQWSDLNTALNDSIQILNDRFASTQLTENEALVFESLKRNIRSLREYELKLQRNDPLNTELTTSGSERYFTAVYDDLDALFKIQLEESDKVISNANRAIDTSNLISRIEIGVLIAIGLLIQLLVFMRPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E505</accession>
    <name>A0A654E505_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">MARINOS108_20941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="395" mass="45544" checksum="3B63CD74D4C65808" modified="2020-04-22" version="1">MSLTMSTVLYYGFQIQGYIDFMLNKQNYLLILRTYLIHDFWSIQAFNMKLSAFKFDLPSSHIALHPTENRDESRLMVIHRDTGEIEHKTFKDIVDYFDEGDMVVINDTKVFPARLYGNKEKTGAKIEVFLLRELNKEMKLWDVLVDPARKIRVGNKLYFGEGELVAEVIDNTTSRGRTIRFLFDGEEDEFYRMIDRLGETPLPKSIKRSTVPEDRERFQTIYAKNVGAVAAPTAGLHFTQQVLKRLEIKGVDINPVTLHVGLGTFRPVDVEDLTKHKMDSENYFVPEPTAERVNRALDEKKRVLAIGTTVMRTLESSVSANGRLKANEGWTDKFIFPQYEFKICNALVTNFHLPESTLLMMAAAFGGYDLIMEAYKVAMKEKYRFFTYGDAMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E542</accession>
    <name>A0A654E542_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="24400" checksum="5055604371B8D322" modified="2020-04-22" version="1">MFGRYSQARKIFCVGLNKTGTTSLKFALGELGFKVGDEEKAKGLLDSWAMRDFRPIVKYCKSAEAFQDSPFSFPYTYVALDQAFPGSKFILTERDDPDQWVSSLINFHGKLWANGQTPTKEHLQAAFNSSPGRPWKVNRLLFDTPESDPYNREILIRFYNEYNRGIKDYFKERKMDLLVINLNDKSSYNKFCSFLSVNPVREVFPKLNSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E545</accession>
    <name>A0A654E545_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_60129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="203"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="32220" checksum="BBF17D99159AF6B2" modified="2020-04-22" version="1">MKNIWILIFPLLVFSCNKNNDFTTETGVEVSCLVKGDGLGAQKDSIVVLYLKIVGADGEVLTETTPEKPLALAFDPEMKAGNLQEVLKEMEVGDSVFFTTTAKNLFEETYQTQLPPDMDSAAVMSINMKFHAQMSQEDYRAYVQEMTEKQRAKESVILEEKLVSDGETIDAYLEENGIDAITTESGLRYVITQEGTGATAQPGDEVTVHYAGRLFSGEPFDSSIERGQPFKFNIGQGRVIPGWDEGIAYIKAGGKATLYIPSPLGYGSRGAGPTIQPYSILVFDVEVLEVGQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E557</accession>
    <name>A0A654E557_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Group 1 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="41733" checksum="675A29D504C507A9" modified="2020-04-22" version="1">MKLLFLTPYPIQRAPSQRFRFEHFFKFMEEMDLTYDFSSFLSEKAWGIAYQRGNFVNKGFYVIGGYLSRIKMLFTLGKYDFIFIHRELTPFGPPVFEWLITRVFKKKVIYDFDDAIWMADQNHENILWKTLKWRSKVASICKWSWKVSVGNEYLGDFARKYCDDVVLVPTIVDTSIHTPPIHQKHPIPVIGWTGSHSTLFYLDTILPALTLLQERFEFEFLVIANKNPNLPLKHFRFLAWKKETEIEDLSLMDIGVMPLEDTEWSKGKCGFKLIQYLSLGVPAVASPVGVNNEIIQEDFNGYFAQTTEDWVSRLSTLLQDHQKRKTLGNNGRLLIEQKYSVNSQKQTFFNLFNDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D3</accession>
    <name>A0A654E5D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="267" mass="30521" checksum="5D6CD397AB10F199" modified="2020-04-22" version="1">MDHLYKYFRWLSLDIVLGAIFFLLYLERYYALQFSVHVYLALGSAIWLIYTTDHLIDAWKVSTPSSERHRFHKKHFSTLVLVGGFVLSLSLVNIHFLEVVIIRNGALLSAVCILYLMLVYFFKALWVKEILVALAYAAGIFLAPLSMTEIELLDFILCLQLAGIAFLNLVVFSAYDESADRRDGFNSLVIRLGDQKVQVVVWVTVLSLILSCGGIYFYTGNPIQLLFMSMIVLLLWVHSSPAYFSRFERFRVVGDGVFYLAGLFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5K5</accession>
    <name>A0A654E5K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="22144" checksum="F5477C216E53C908" modified="2020-04-22" version="1">MTSHAVRLIINTFIGFWFLTAAAQEVVVEDRYDEVFGLKPAFYLGLRSDLNMEDAAMGLEAGLMNKARNLNLFTTFDARPFRKKTLEYRGNNVFYQYPEERYFLGLGAEYLQHFEVADLGAFAQFNGVYTWGVYGGTERKPPNGWVAIPRFGLFRKVGDSAFLKLGYSYFDTKTSKVDRHRVFLSFGGFITRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E698</accession>
    <name>A0A654E698_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="24" mass="2741" checksum="09C25F907CBF2F50" modified="2020-04-22" version="1">MTLAQENNMLKVEQTDYITGIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6B3</accession>
    <name>A0A654E6B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein YiiM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="YiiM-like_3-alpha_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="23710" checksum="635DF61055A993F7" modified="2020-04-22" version="1">MQVVSINLGERQTVRWKRKEVETGIFKYPVNDHITLGYEDVENDHVVDRKYHGGIDKACYLFSADVYPSWKTRYPQLSWDWGMFGENITVMGLDESKIHIGSIYSIGTAVVEVSEPRQPCFKLGIRFGTQKVLKEFIAAGHSGVYLRVITPGKVKAGDQMSLIEEGSDISILDIFQLFYHQHKNPELVHKALELEKLATGARRNLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6G4</accession>
    <name>A0A654E6G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021694">
        <property type="entry name" value="DUF3276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11680">
        <property type="entry name" value="DUF3276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="14158" checksum="280801EC7DD3E37E" modified="2020-04-22" version="1">MEENKEKGRDEIYSERVRAGKRTYFFDVKSTRSNDYYLTITESKRRFKDDGFFYEKHKIFLYKEDFNKFVAALNETVDHVKNELLPDVDFSEFDKVHEEDEETIDVSSEDDSELKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6I3</accession>
    <name>A0A654E6I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="26790" checksum="794BD4094DE841FD" modified="2020-04-22" version="1">MNLNLNSKYALVCGGSKGIGAAIAEALAAEGAKVILVARNEEELQAQLSNLKGTGHTSVVADLSRQGDVDRLAQHIREKQVDIVVNNTGGPPPGPVSEATWEDFERAFSMHLHASHQLMQAALPAMKEKGFGRFINVISTSVKIPITGLGVSNTTRGAMASWAKTLSNEVAPHGITVNNILPGAVETTRLEAIISNTAEKKGISEEQTAAAMRSGIPAGRFGQPDELGALAAFLASDKASYITGVSIPVDGGRTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6J1</accession>
    <name>A0A654E6J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase A subunit family amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="546" mass="60291" checksum="B5CF4BD10AF9BD9A" modified="2020-04-22" version="1">MRKLIFTVITCLSVLVVQGQQDSIFQAMKLFGLDFTQEEVDSLRGGLEDNLSDFRKIRMQPLPNDLPYSLVFVPPVNLDYISSEQLEVDFQQPGQVEMPAKIEELAFYSVAELSVLLQTRKVTSLELTKMYLSRLKRFGDTLQCVVSLTEELAMEQAKKADEEIAAGRYRGPLHGIPYGVKDLLAVKGYKTTWGAMPFKDQEINYTATVVEKLEAAGAVLVAKLTLGALAWGDVWYGGVTKNPWNLEQGSSGSSAGPASAVAAGLVPFAIGSETWGSIVSPSNRCGIMGLRPTFGRVSKYGAMALSWSMDKLGPMCRDATDLALVFDAIRGSDGKDLEVLKDYPFNYEYDVYKVKNLRVGYLKGLFEASDYNKSNDSTTLALLRNQGLKMIEKELPTEIPTSALGFILSAEAAAAFDELTRSNQDDELTRQIINAWPNVFRSARFIPAVEYIQANRLRYLLVQQFNEMMADIDVLIAPSFGGDQLLMTNLTGHPCVVLPNGSYEAGSSGTITLIGNHFDEASILSFARYLQALTPFEDEHPQMFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6U7</accession>
    <name>A0A654E6U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altronate oxidoreductase</fullName>
            <ecNumber evidence="3">1.1.1.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uxaB</name>
        <name evidence="3" type="ORF">MARINOS108_90028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.58" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009026">
        <property type="term" value="F:tagaturonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="2">
        <location>
            <begin position="204"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="471" mass="53431" checksum="66D433100CAA27D3" modified="2020-04-22" version="1">MKKLSTTERITQHPIKVIQFGEGNFLRAFVEWMIELLNEKSDFDGSVAIVQPLQNGLIHLLKEQGGLYHHVRQGIENGETIDEVKLIQCVSEVINPFEEQAAYFALAEIPSVQLIFSNTTEAGIVHEATDRPEAGQMANTFPGKLTQLLKHRYDHFQGDKGKGVAMIPCELIEQNGTKLKKCIAQYIDLWNLGEGFKTWVNETCAFANTLVDRIVPGYPKDEIEVITERIGIKDQLVVKSESFHLFVIEAPEFVQELFPAHRLGLNVKYVKDITPYRTQKVRILNGAHTSMVPIGLLYGLETVSETIDDTETGKLIREIIFDEIVATIQIPGEDPKEFADQVISRFRNPFIRHELISISLNSIAKFKVRVLPTILDYLRIKGHLPNKLIFALACLIHLYLRDTDRLKDDETYLNFFESLKSDEPETLVNKVLANSSLWDQDLTAVDGLSDLLTTHFKAIASEQMKEVLLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E764</accession>
    <name>A0A654E764_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusC/RagA family TonB-linked outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="491"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1104" mass="123092" checksum="EBEAEEC1CBC48FE4" modified="2020-04-22" version="1">MHAKLQKLIIRMSKIAIYAIIMCYSLTMAFAYETSAQRKYLSEISFELNYEGKRLIDLLEEIEGSSEFSFAYSKRELKDKSIYLTTGKWNMDDLLKEISVQARVSLRRINETITIKKVNEAEKLPVVSEVVYVKREISGRVIDENEEGLPGATIVEKGTTNGTITDIDGQFKIEVSEEASLLISFVGYHTQEVTVGDRTNFDITLEPDYTSLQEVVVIGYGEQKKADLTGAVSVVDTEELQKRQATTVAEAMQGLATGVNIRGGGQPGSEAQIQIRGLSNFSNQPPLYVIDGMITTANRDFNPNDIESIQILKDASAAAIYGSRAANGVIIITTKKGREGPLQVKFSGKTGVQQIPRYELADRDEYIQLNNMAYDNAGVPRQDHDLTNDTDWQDEAFQSGRIQDYNLSFSGGGPNGNYLISGNYFENKGTVISTGFERMSFRVNTSAKKGIFSVGENIAITNAQADEMSGNPIFDVIRLMPTIPVYDENNPGGYGYGNEARARTFGTNPVAIAELEDRTNANFRVRGNVWSELQFLPSLKYRVNMGYERSNDHYQFLRKEGNWTLNQPYDPSIAIENRGESSTLLVENTLNFNKDFGKHQVDVLLGQTFQNDKYARMEGVKRNLPQNPTTGQYYTVLDQGDQAVVTGFRQEAVLISYLGRINYTYDNKYILNAVFRKDGTSRLSKDNRWSSFPSLAAAWRISDEAFFNSSLISNLKLRANYGTLGSSNIGYWDYQQTINTFPTIAMGRDQHIEPGGTNIRLANNNLRWETLTQKNFGLDLGLLKNKLTATAEYYISETKDVLTEAPITLTTGNDGGNPVVNAASLKNSGFELSLTYSEAEKAFKYNTTLNVTTIKNEVLSLGYGRNDIYVGNTVTEVGQPIGMWYVLETDGLFQTTQDIEGHTTDGQIIQPGAQPGDIRFVDHNGDGQITNDDKVVMGNPWADIELGFNFNASYQNFEFSMTWFSSLGATVYNGPMSLMGRFDDNSNYPAGIKPWTPENPDTDVPRAYYGTTLNSRGDADRWLENGNFARMKFISLAYNLPSAWVERIGFETAQVSISGQNLITLTKYSGLDPEFRGPGIYERGFDLGAFPNVKTFSMGLNFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E845</accession>
    <name>A0A654E845_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="162"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="406" mass="46284" checksum="43D13BDFFD15DD6E" modified="2020-04-22" version="1">MPVSLGLISDNSNLYWKGVRYLHCHFTFILMNRIFTLAFALVLSLTLFGQESDSEPVMDFERYDPISSLVVPEHPVTRARFPFIDVHSHQWNLTKDRIAKIVGEMDTLNMGIMVNLSGRGYDREAGDIGSQEYLAGMTSRIAGEAPGRIVVFTNVSFKEIGNPGWSEEAVRQLEEDVKNGAKGLKIYKSLGMGINDVNGNRVAIDDPRIDPVWAKCGDLGIPVIIHAADPKPFWDDHDEKNERWLELKLRPGRKRSTTDPAPWEQIIAEQHHIFAKHPGTTFINAHMGWMANDLQALGDHLDQYANVNVGIGAVIAELGRQPRAAKAFFEQYSDRILFAKDAYNPEEYYTYFRVLETADEYFPYYKKYHAFWRMYGLDLSDEVLKKVYYKNALRIIPGLDASLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8F3</accession>
    <name>A0A654E8F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_12157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="52"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="46733" checksum="C1EB2B7F0A7E80F7" modified="2020-04-22" version="1">MNMITNLLMIVQDSVAVADTIAAVVPEVVETVAVATDYSADITANLLTANNIWMMMATALVFIMHLGFAGVEAGFGQSKNTVNILFKNTLTPIIGILTYALVGFNLMYPGFDVPGWFGFAGFGLETSATADISAEYAGAGYTYWTDFLFQAMFAATAATIVSGAVAERVKLGAYLIFTLIFVGVVYPIIGSWKWGGGALDAMGFYDFAGSTLVHSVGGWGALAGIMIVGPRLGKYVDGKVIDKPGSSVPLAVIGVFLLWLGWFGFNGGSVLSADPGLVSFVLVTTSLAACAGGLGGFVTGYLVFKRLDLGMVLNGILAGLVGITAGADVIEPGNAIIVGVVAGILVVISAITLDKFKLDDVVGAVSVHLTCGIWGTLAVGIFSINADHTFMAQLKGVLICGAAAFICAFIIFYVLKLTIGIRVSEEHEKEGLDSHEHGIRGYTIIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E994</accession>
    <name>A0A654E994_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025003900" description="LTD domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="363"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="790" mass="82975" checksum="0D5A999C4B199BBC" modified="2020-04-22" version="1">MKKTYSLLLLLLIVFTAGAQAPAGYYNSANGLSGEALKSALNDIIDGHTEYSYANVWDLLKVTDVDPNNPNNVMGIYSRFSMDAAAEYAGGAGWNREHVWAKSRGDFGTTMGPGTDIHHIRAEDVSTNSARNNRAFDEGGTQYIDGSGNYSGPTPAKSGTDYTWYPGDEVKGDVARMIFYMATRYEGENGEPDLELTEEILSNTDKTPFHGKLSVLLLWHEQDPVTTLEMDRNDAIFSYQGNRNPFIDHPEYVASIWGSGGGGGGGGGSCADTEVTFTLVTDNYPAETSWTLTKDGSTVASGSGYTAANTAHVESLCLADGTYDFTINDQYGDGICCSYGSGSYEWTSSAGTLASGGQFTSSETKSFTIGSGGGGGGGGGSTGTVIISEYVEGSSNNKAIEIANIGSTSVDLSAYTLKKQTNGAGSWSSPLSLSGTLPAQSVYVIVYSSAGSTLLAKADLTTSSSVMTFNGNDPVGLFENDVLTDIVGTFSGGSGNFAQNVTLQRKATVAGPSSTYSTAEWTTLTQDDFDNVGLLTGGSSGGGGGGTGGTMPTGYCASQGNNSSYEYISSFSLGAISNSSGNDGGYGNYTSLSTTVAKGQSYSFSLTPAFPSGVYDEYVKIWVDLNRDGDFADAGEELFSTGPIQSTTTGSITIPTSASEGITTMRVSMKYNGAPTSCEAFSYGEVEDYAVTIAASGSRIAEVQETTTFTTELYPNPAEDFVNLHLKVRTEDYLQIQISDLNGRIVFTDARKAVNGFLTTQIKTGTFGSGFYFITVTGGGETFKGKLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9T5</accession>
    <name>A0A654E9T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29030" checksum="63E0E7070ECD3889" modified="2020-04-22" version="1">MAIVLLLGCAQEEERIVTIYLIGDSTMADYADNYEEGKDYYKTRYPITGWGQVFQPYFSTDLSVFADLFSADSVVVDDRARGGRSTRTFFQEGRWRSVYESLKPGDLVIMQFGHNDAAEKKTERYVDIEGYKEFLRLFIAQSKQKGATPIVLTPVARNYPWENNRLQNVHGEYPDAALEVAREMNSLFIDLNQLSMNAFFKVGREYVTQNYFMNLDSGVYEAYPNGQSDNTHFQPEGAKVVAGLVFEAMKTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB66</accession>
    <name>A0A654EB66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TraR/DksA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_140128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14107" checksum="7AEB8B99DA9576C3" modified="2020-04-22" version="1">MAEKTKYSEDELKEFEELIHQKLAKAREELNILKGSLTRDTDEGTDATHGAVKTLEDGADTAEKEQLSTLAGRQQKFINNLENALIRIKNGTYGVCVDTGKLISKERLRAVPHTMHSIEAKLNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFC2</accession>
    <name>A0A654EFC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018914">
        <property type="entry name" value="DUF2480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10652">
        <property type="entry name" value="DUF2480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="168" mass="19113" checksum="7A15F6827292C1E9" modified="2020-04-22" version="1">MEEIINRVSKSPLISLDFDEYIDQSERAFFDLKEGLFHGMILKEKEFREFLRDYDWLAFKGKNVGVVCSADAIIPSWAYMLVVTRLGGVANLSAFGGEEELEKALINRAIDKILEQDLEGAKVVIKGCGDIKTRDYAYFELTRRLLPMVSSIMYGEPCSTVPVYKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSV0</accession>
    <name>A0A654DSV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pfkA</name>
        <name evidence="17" type="ORF">MARINOS108_10156</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD10660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="34440" checksum="2EB89E97398242A8" modified="2020-04-22" version="1">MKSIGVFTSGGDAPGMNACIRSVVRTGLYLGLDVYGIKYGYNGMIDGDIYKMKSYSVSNIVQRGGTILKSARSKDFMTKEGRAKAYEQLKKRGIEGLVAIGGDGTFTGANIFYEEYGIPIVGAPGTIDNDLYGSDYTIGFDTAVNTALDAIDKIRDTANSHDRVFFIEVMGRHSGYIAIQSGIGGGAELVMVPETSTTIGDVIQTLKEGRDNQKTSSIVVVAEGGEQGDALEVAAKVAKELPDLDIRVSTLGHIQRGGSPTSYDRILSSRLGMAAVEGLVNGEKNVMVGVVNDKIAYTSFKLAISKAKPINPELMRLVDILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT82</accession>
    <name>A0A654DT82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024950258" evidence="1">
        <location>
            <begin position="40"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="33265" checksum="9EA84139B7FB7AC9" modified="2020-04-22" version="1">MCCQRVRNQFRNQKNSIMKKLSFLVSVLSALFFALLFTACQDDSGAMESSTLSETASVSVTSEAAVASSMEDVDLLADAGMELFATSGRGLRDHLLECAEIAHDTASHVITIDFGDGCEDRFGTWRSGKIVIEYNERKYVPGAYRIVTFEDFFLDSVQVEGTRTITNVTDTSGTGIAFETSLVGGKLTFPDGSTITREAEHLRTLYVGEEREDNYASLSGSASGTLQNGNTYSSTIMEDLIFKRGCKATGVHIPVAGVLEIVSGDNTVVIDYGDGECDNLAEVTTNGETETIEVEPRGRRRPHKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTI3</accession>
    <name>A0A654DTI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11819" checksum="33038D5499489591" modified="2020-04-22" version="1">MIFITQLIYVIEGQEAVFDQFESIAIPTILKYNGRLLLRVRPDDQAIIERHIDKPYEIHLVEFDSEQDFKNFAQDEERKKFLHLKEQSIKASVLVQGTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTP9</accession>
    <name>A0A654DTP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="24542" checksum="1EA014325FE646D4" modified="2020-04-22" version="1">MVAVIRMLSASTNEHMKYFSTYIFALFLLTGCNNNNQQQASTQEATTPETTNPVTKTSELSAFELYVSTLEQIPLPLNHNPLGQLPELSNNYDKNGFANYKHVWTSQPLGIYFNDGETIGIIDCSIGDWGLVPFLTIYDKQGNKIDSTSFYKKSGGDMGYQAIEYLTLEANRHIIVLDTVKRWNLNEDESDIIENSMQQTIGRTEYQVLTNGMIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU13</accession>
    <name>A0A654DU13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="244" mass="28230" checksum="6D4E80A66CB409C1" modified="2020-04-22" version="1">MKDLFSSGSDRYAMFRPTYPDSLYEFISTQATHHNCAWDCATGNGQVARHLTGHFKEVQATDISAAQLSEAYPHPNIHYSVQPAEQTTFPDQHFDLITIGQAIHWFDFDRFYLEANRTLKTNGIIAVIGYGLHSVSPDIDPIIRQFYYEVIGPYWDPERKYLDEKYQTIPFPFKEIATPAFECVFTWSRAHFLGYLRTWSAVKKFIDQNGSDPVDDLDKAIEPLWGTEQKITFPIFLRLGRKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU41</accession>
    <name>A0A654DU41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase/N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="36418" checksum="F92B2582C08AEB16" modified="2020-04-22" version="1">MNNKLIDLKNRIQGPVYSVMTPFLKNEEIDFLSLENSLQRIYDGGGRIFYVMGYNSRFSELSWEEIRLLNSFVTQKVKAIDSNNIMIVADPLHCSTKISIEFARHAQEIGADLISIINREKFYSEEQIYRHYKMIADAVDIGILVHEMPFLNGYGGPVVNWPISLLDRVVDIPNVIAVKEDAKDDAFSKQVIEKIKDRAAIIISGGGKRQWLQFAEVGCQSWLNGIGVFDPRLASKFWEYYQAGNKEAYMRIINEIEVPFFEKGVKKYGWHLTIKAAMEALGVIHRYERMPLMELGAEEAMDVKRLIESLPVDEVVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU62</accession>
    <name>A0A654DU62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="25841" checksum="C1848D763FE3DEC6" modified="2020-04-22" version="1">MKDLHGKAILDYYKGNDEATLILHNSYGDPDEMPVEVFFREEEDFTTLEHLALIESKGRVLDLGAGAGAHSLVLQSRGFDVFALENSPGCVDVMRRSGVRNVLFEDFRKHQGQYDTVLILMNGLGLAGTLGQVEVFLQTCEKLLSPGGQILVDSSDISYLYEDGTPKPAGYYGEVRYRYEFQETKGDWFDWLYVDQQTLAEKVAAVGMELEILMTDENDQYLACITRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX1</accession>
    <name>A0A654DUX1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">ku</name>
        <name evidence="5" type="ORF">MARINOS108_10818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="53"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="280" mass="31689" checksum="BDE9E5C869C3547B" modified="2020-04-22" version="1">MRAIWKGHIRFSLVTIPIRIYNAIDNKQTISFNLLSKETHNPVKYEKKDKVTGETLRTEDIVKGYQYEPGQFVIVDNDDFEKVKLKSTKVIEIEGFVDASEVHATLFDSPYFAGPDGDVAAKTYGLLSEALRASGKVGVGKVVLRDRENVVLLTPHEGGILLYKLRYPEEVRSIKQVPKLDTLEEAIDAEQLKMANTLIDSMTKSFEDIKLEDRYNGALKEVIMNKIEGKEVISITEEEPEVVDIMTALKQSIEQAKADKKPMKKAKKEVEETKKKRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT4</accession>
    <name>A0A654DVT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="146"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="27906" checksum="A019C298DDA8279E" modified="2020-04-22" version="1">MTYKEIIPGRHLQSKIHNFWELKGEASSNKWERIFPDGCPGLIINLGDKCVTDNGATCMDHGKTYVVGAMTSFKESYIDEHTHLIGVCFKPSTFASFFSYASLGEVKNKTVQFDQNLSFNKDQFFNGNYIDYLNQFFYDKVCSKTIRLRTIIDSMQASKGLLTINELSKQNGISPRQLERLFKDFIGLTPKEYSNIIRIQQALALIESNNNNKALLDIAFECGFYDHSHLTNAIKQHTGFVPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX8</accession>
    <name>A0A654DVX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="51581" checksum="86B7B7B22BBD8C22" modified="2020-04-22" version="1">MKLNSITVEKLFGVFDHHIPLHQEEGITIVIGENGLGKTVLLEIIESFFKRNYFYFNTITFDKIVFEFDDTISWHLQKTDDILNVTQVNKNKSEYNPLLLLDYGRRDWEQHASRITRYVPYLRRIGSRRWEDRRTRELLDFEDIISRYGDLVPYDPYVKEVEDFPKWFIERHNSINVTLIETQRLITLVEREDKRHEKTVEKYSNELSRTIKSYLAQSTELSSKLDRTYPNRLIDRLKQSSNATDEALNEELKKLEEKRALLDAVGLIEIEKDSGILKIEKPEDVVIDVLMLYVEDSFKKLEIFDKISSRIEVFLEILNKRFKHKKLHIDKESGFLLKSTIIKNKDGEFQDIPVTKLSSGEQNELVLFYELLFKTENSSLILIDEPEVSLHISWQNSFIKDLREIIKLNKLEVIIATHSPDIIANNWDLKVELKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW32</accession>
    <name>A0A654DW32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA ligase-associated DEXH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026362">
        <property type="entry name" value="DEXH_lig_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04121">
        <property type="entry name" value="DEXH_lig_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="249"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="818" mass="92767" checksum="56EA11FF379BD8A9" modified="2020-04-22" version="1">MKDELEPALAWFKSRGWEPFDFQKETWQAYLSGHSGLLNAPTGSGKTYALWIPCVLEFLRDHDPSEVTPELRILWVTPLRALAKDIQRAMQAVCDEMDLRWTVGLRTGDTTTSERQRQKKIAPQALVITPESIHVLFSQSDYPNFFKGVKAIIVDEWHEILGTKRGVATELAISRLKHITESKLKVWAISATIGNLPQAKRVILGEDAYKEGVVIKSRLEKKVEVESVLPDEVEKFPWTGHLGTKLLPKILPIILKSKTTLLFTNTRSQTELWYQAILKFAPELSGIIAMHHGSMDHDIRGWVEDALHAEKLKLVVCTSSLDLGVDFRPVDTVIQIGGPKGVSRFFQRAGRSGHQPGATSKIYFVPTHSLELIEGAALREAIEEGMFESRNPLQKSLDVLVQYLVTLAVSGGFRPLQILEGVRQTYSYRLLTAEEWSWCLDFITTGGKTLGQYDEFARVYNDDGVYKIINKKAATRHKLSIGTIVGDPALKVKFITGGHIGTIEESFVSRLNVGDTFWFSGRNLEFVRIKDLTVLVRKSNKKSGLTPQWMGGRLPLSSMLAFKIREKLDGAIGGDYSSVEMQTIRPILDLQSRWSMIPSSKQLLIEKTKTRFGHHIFIFPFEGMFVHEVLAGVIAMRISRIRPISFSISMNDYGFEMLSDQEVPIEEALELDLFSEENLIPDIYESINMTEMAQRKFRDVATIAGLIFQGYPGKNIKSRHLQASSGILFKVFEEYDQGNLLVRQSMEEVMTLQLEHSRLFEAVRRINQQTIILKETIKPTPFAFPILVDMFRRQKLTSEQLADRIRKMQIQLERAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW77</accession>
    <name>A0A654DW77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactam-binding protein with PASTA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="31314" checksum="3AD491BBA40D3E1B" modified="2020-04-22" version="1">MSIFKVNSWKDLALHAFIIIGLGVVFIFIFFFIYLPMSTNHGETITVPDVRGITLDELDDFLGMRDLRYEVTADSGFSANLPPLAVLKQFPQPNAKVKENRKIYVTLNAERAPLVRMPKLVSGSVKNAQLVLKTYDLELGEITYVPDLALNYVLEQRTDGREVLEGERIPKGSIIDLVVGDGLGKQSLESPNLIGLDLESAQFAIVGSGLKIGETKYEKEGVAVIETEMEDGTFTYKEQKVSPGAVFKQRPSAGIRMRLGQMVDLWVYSPDSLNTNPTLLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM1</accession>
    <name>A0A654DWM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4807" checksum="45180BF495699CF6" modified="2020-04-22" version="1">MIIARMNSRFIRDELSGEDMFIATGLKSEEQKKARLLGLFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM2</accession>
    <name>A0A654DWM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="20088" checksum="1C2942F51950C9D2" modified="2020-04-22" version="1">MENVTVVDFNVPTKSEVSPTNQEIFDKLNGALGFVPNLYATIAYSDHGLKRYLDYQNAKTSLSNKEKEAVNLVVSQVNGCIYCQSAHLVLGKMNGFDDNQLLDIRKGQNENPKLNALVKLAADITQNRGNASNSNIEDFFSQGYTKENLVDLILQISDKTAMNYLHNLTKVPVDFPVAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP0</accession>
    <name>A0A654DWP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="17572" checksum="DFF4D3691318012E" modified="2020-04-22" version="1">MKTYRRLAITIVTVLTIYGCENRDINEGEAFRPREIHEDIVFNFDKITVDGIEYLILEKDNNNPHEGFGFMAFRANKLMEKQDTVMAYLRTMRDFQVLTYAAISKRPVEQVNEDFNRLFNYYLNEEETELLQLEESNLRSSRATTPGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT0</accession>
    <name>A0A654DWT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-(Acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lpxA</name>
        <name evidence="7" type="ORF">MARINOS108_11499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="174"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="28612" checksum="8F66C91534883A07" modified="2020-04-22" version="1">MTSTLSYIHPQAQIAENVTIEAFCSIAADVVIGEGTWIGPNSTIMDGARIGKNCRIFPGAVISAEPQDLKYKGERSTATIGDDTIIRECVTINKGTRLDRNDTKIGRNCVLMAYTHVAHDCIIRDHVILANAVQMAGHVHIGEYAFVGGTTAIHQFVKIGAHTMISGGSLVRKDVPPYVTAARDPLSYAGVNSTGLRRRAFSNDKIREIQDIYRIFYLSGLNNTEALDKIKMELNPSVERDDIIKFIEDSNRGMMRGNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW0</accession>
    <name>A0A654DWW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="28864" checksum="072A7EB1484981DE" modified="2020-04-22" version="1">MSIIAENIKFLRKQAGYTQEQFANQVGIKRSVVGAYEEARAEPRLQTLMSIAEVLNVSTDDLIATDLTTGKGSSPRDKVRILSITVDKEDNENIELVPQKAAAGYMNGYSDPEYISELPKFNLPMLPKNATYRAFEISGDSMLPITSGSIVIGRYLESITEIKNGKTYVLVTDREGVVYKRVFNYIEEKGTLYLVSDNKSYSAYEVDPKEVMEIWEAKAYISIQFPDPEAANELSIDKIAGMVLNLQHDVNEIKKNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX49</accession>
    <name>A0A654DX49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15536" checksum="8F0EFA31AC79DC43" modified="2020-04-22" version="1">MITYQIEKDLSPEEFISVLNQSTLAERRPVNEPDRIQKMLDHGNLIVTARENNVLIGVARSLTDFLYCTYLSDLAVDQAYQKRGIGKELIRQTKLQTPKAKLILLAAPKAVAYYPKIGMKQWEQCFYMDDINELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX52</accession>
    <name>A0A654DX52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ORF">MARINOS108_11525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="40696" checksum="E16CDE5261755A02" modified="2020-04-22" version="1">MGLRCGIVGLPNVGKSTLFNALSNAKAEAANFPFCTIEPNVGVITVPDERLEILKGLVSPERVVPTVIEFVDIAGLVKGASKGEGLGNQFLANIREVDAIIHVVRCFENDNIIHVEGRVDPVDDKEVIDTELQLRDLDSVDKRIARVEKIAKGGDAKAKKEYEVLIQFKKHLESGRNARSLEMEKEDRVLVKELQLLTDKPIIYVANVEEENVNSGNQYSQKLEENVASENAEVVRVSAALEAQIAEFEDEDDKLMFLEEYGLKESGLNRLIKAAYSLLDLITYFTAGVQEVRAWTIKRGWKAPQAAGVIHTDFERGFIKAEVIKLENYQQYGSEQACKEAGKLSIEGKEYVVLDGDVMHFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE0</accession>
    <name>A0A654DXE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="16551" checksum="7D17CA9E3B1A5C1D" modified="2020-04-22" version="1">MSNKPPKELLVEGPIPPEKLATSVANHQSKTSIGAHSIFLGQVRADEVNGQRVAAIEFTAYHDMANAVYTEIRDEAFAKYELTCAHVYHSTGLIAVGELCFYVFTSSPRRKAAMEACEYFVEQIKARVPLFGKEIFEDQGHQWKTNTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE4</accession>
    <name>A0A654DXE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="20123" checksum="7FE5BCDEEC02D6EA" modified="2020-04-22" version="1">MNKIGKPKPEEYANFYRGYIELVGDQDVIEYLSDQSDSFSTYLEKIPKEKMSFAYHEGKWTVAQVLGHIIDTERVMAYRILRFSRQDKTPIPGFDQNTYVENSFFEARSITSLRAELMGLRAANIELIKSLTEEQTKYTGQSNEVIFSVRALVYILGGHLAHHWNILKERYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG4</accession>
    <name>A0A654DXG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small subunit ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="284"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="369"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="458"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="545"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="701" mass="77419" checksum="5BC5BFCF4C190970" modified="2020-04-22" version="1">MAEDKKDELQDVENTEAQAAETPEETKAVEAAEETPAEEAKKEVAEEVKAEPAKEEVKAPVAKEVKAPEVQAPIAEAEVDIWDTAVDDGFGEEYSDKDRKKMEALYEATLNQITEKEVMAGTVVGITDRDVIINIGFKSDGLVALSEFRDVEDLKPGDAVEVYVEEQENANGQLVLSRRKAKIVKAWENIQKGLDEDMVINGMVKRRTKGGLIVDIFGVEAFLPGSQIDVKPIRDFDVFVGKKMEVKVVKINYANDNVVVSHKVLIEKDIEKQKAVILENLEKGQVLEGVIKNMTNFGVFIDLGGVDGLLHITDISWGRINHPEEVLSLDAKVNVVVLDFDDDKKRISLGMKQLTAHPWDSLDKDMTVGSKVKGKIVNVADYGAFLEIIPGVEGLIHVSEMSWSQHLRNPQDFISVGDQLEAVVLTIDRDDRKMSLGIKQLTEDPWTKQDVLTNYAVGTKHTGIVRNLTNFGLFIELEEGIDGLVHVSDLSWTKKIKHPSEFVKVGDELEVVVMELDVDNRRLALSHKHLEENPWDTFETVFTRGSVHKCTVISKNDRGGLLELPYGLEGQVTTKNLQKEDGSQANEGETLDFKVMEFSKDEKRIVLSHTSTWKEGAEQPAPAAAPAPKKGKSSKGNTLNKINQETEKSTLGDLEALSALKDKMESAAKPAAAKPAKKAAPKAEEKAPEAEGSEEESKDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT5</accession>
    <name>A0A654DXT5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="16452" checksum="A77B238469D70C30" modified="2020-04-22" version="1">MDYIFKTENNTRYNFPTHINDIVMDRSEARFSEVFMVVLETEKAPPIHKHDDTEQVFYVLNGTGTLRIGQNVEEEYEVSPGDVVRIPVSTWHSIVADRGEEVKYLAIDCFGGIRNEDEPTWESHVKVICKEQGWDFNQVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY01</accession>
    <name>A0A654DY01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9289" checksum="A6BC47BF63F22C4D" modified="2020-04-22" version="1">MLGILIVITAVHILIHEKKSRLVFLKTLGLVFIPIFLISIISIMASAAFEVNNGLKQLDNIVWVALGISTVFTTVYFVFQQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY10</accession>
    <name>A0A654DY10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hybrid sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="836"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="1247"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1345" mass="152194" checksum="3DBAFEA3202682BA" modified="2020-04-22" version="1">MKQHLPIIFLLILSCFYAGSQSIEFEHYNDKDGLSHNSIRHIVQDNQGFIWLGTFYGLNRFDGFQFQNFLSNDEVRNTLYNDDITALKLDSAKNSLWIGTRKGLSRLHLDTHVFTTYLSDDDDPNSLPDEEIRSIYLDRFDRVWVGTKDSGLYMFEPDKSTFTKVPLEGVNYVKEIFEDSQGNIWIGAYESAGVAKVKLGSTGIISEIEYFTLEVPGASAVNPYLYFIYEDEQGGIFVGTRKGLYKFDRSLNEFNNLEIPDDKVSEKLGPYFLCVAQAPDGKYWVGTLGGLLVCDALEDISEGKFQWYFSVLSEDNSLVDNLVSALYFDPSGVLWIGTEEGLDKYDPYENQFKINKDISKYIDNQAPRIRGFSKTYQDEVVVATRHNGLFISDEGNFVPLFNGPYDIASIYSHDGIVFYCGLWNGKILIYDYLKKSSSIVDVGFNNTPIFDFRVFAGKLVVCSHGEGALLLDMQTYKPSLRILPGFDINKVGVDLDDNLWFATESGAVRYNLANGKADVFLAESQTSGGLPHQNVSDVNIDSRGMIWAATRKGLGVFDPESNAFRQISEPKELKDKWVTDVVEDANGFLWLNMNNNNICRYDVGSNQANIYNVNSGNRLDVFSSSGFYNFNNSKVYLGGKNGVISFSPLNIKENEWSPKPIITEFKVNNELVLPGVQLNGQVLLDRSLNYSRSVSLNHENRNFSIQFSTASYTNQRLNKFQYMLEGFDEDWVETSGNSRTVQYTNLLHGTYNFKIRASNSDGKWSEVSSYSIQILPPFWASYQGIALMALVLGLFGYFMRKQIKFRIQLKQELLTEKVQRERDEKLNNEKLRFFTNISHELRTPLSLILGPVKQILEHENSNEFIRNKANLIDHSTNRLLRLVNQILEFRRAEAGEVKLKVSEVDILPYTNNIFYSFIDLAESKNINFNFHVEDESIVCWIDVDKYNKILYNLLSNALKFTNSHGHVDLFVGVKEKDTKTLLIEVSDDGIGIPAESQEKIFSRFYQATNSKESTTGTGIGLSLVKSLVEIHKGSISVKSSTDSGSIFTVELPISKSAFESSEISSFIDEKQEVELLGSMKSSNPLDAYVAPKTNTDVKSSVVVIDDNPELRNYVMEYLSEYYKIYGAENGKEGLELCRKVKPVLCVVDVMMPVMDGFEFVQALKGDEKISHTAIVLLTALGENENKIKGYKIGVDGYLVKPFDPSLLKSRIDNIIKTRLELKQRFSDETESDVTSLAHSQLDIDLISEIKEIIEANLGSPDLTPAFLSSELALSSSKLYRKITELTDMSPNEFIRTIRLKKAASLLKTKNFNVSEVANTVGFNDPLYFSRRFKKQFGYAPSDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY53</accession>
    <name>A0A654DY53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22694" checksum="3C36BFD275DD7209" modified="2020-04-22" version="1">MTLEIPQLHIKNMVCPRCVMVVRQAFEQIGVEPISVDLGEVKLKKELSGDELKQLDDLLAKNGFERIDDRKVQLLEKIKTLVIDTIHHRDPYDTHIQWSAYLSDQLHYDYNYLSSLFSGMAGITLEQYIIRQKMEKVKEFLFYDELSVKEIAYKMGFSSVAHLSNQFKKIIGLSPTEFKKSIQQTQSRKPLDQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC3</accession>
    <name>A0A654DYC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024849282" evidence="2">
        <location>
            <begin position="23"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="50181" checksum="7E6AEBCB464B7710" modified="2020-04-22" version="1">MKQLLNLLLALAMVLTLSFCNKDDDPKPGDKDPTDTTDTTSNVVKLTPEQNKELLQTIGVQFVNEMSAMQQTEGIQALTSFGLLVEGEDDDPDPGVPNQLMKINKAIIAFAHGRISANQFGALPVALRTDDDDDDFESLQELFDEATGTYDWNAATEEFDYTDNSSDKIIFKYPTPETGTSNNTTLTFSNYSSVEIANPIDEEYTGDLPTSLDVELKLDGVTQVTYGFEVDYNSEGVPEKVETALFVNPFTLSVDLTNNKSKIGTGVDFSNGTKTLIATSVEFNGDFSDAAIEAAEEDEEKLKDVIHDANFSFTLLDLKMVADVDFANFYPKVYNLDTYYDDYDGNTDPKPDLEANAEKLEAALNDHVSLTTSYVSTGKIAAEVEWYTFVESEEYCCGTDYSVELGARMIFEDGSKVDLEDYLETGFGQLEGAINDLLDQISEDIGEDLEHIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD6</accession>
    <name>A0A654DYD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="25217" checksum="8FF666B97A5C7D4E" modified="2020-04-22" version="1">MIILVSVKSDLHIQRPDLVIPTYNSTEFIAHSLRQVLKHREIFSKIIVVNDASTDATLSALESFKPNIEIISTPTNQGQHHATIEGLKVTSSPYVFTLDDDLPVRLVDLPYLLQHAIREEADLIYASYRGGGLVPKIGSWVVSKIMSLKYRTKVTGSSTRLIHRRTLNRCFEAGFSHFLDHDLLAHASICEFVPLVHQKSQHPSRYSFTQRIALFNQMLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE1</accession>
    <name>A0A654DYE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15612" checksum="6DC9773ECA8A5F99" modified="2020-04-22" version="1">MSSSITLKDTSGQTFFFCIPIYERGIIKCTWTGNLMEISPAKEAALSIVQQLKETGYTKVIDDNRLGSGPWPDFMDWLRTDWINALLKTNLKSYAHVVSPDTNAKQPAYEIFNQTIKNVDFVTFGSYDMALNWLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF5</accession>
    <name>A0A654DYF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NAD(P)H-nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MARINOS108_11721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD13995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129270" checksum="85E61BC02D92F07F" modified="2020-04-22" version="1">MSQKWEESHKTVCSYCGVGCGIVVSKDKKGRLKVKGDESHPVNKGMLCSKGMNLHYTVMDQSDRLLKPEMRWSRRHPMAEVSWDTAIGRAAAVFKTFIKEHGPDSVGFYVSGQCLTEEYYLANKLVKGFLGTNNIDTNSRLCMSSAVVGYKETLGDDTVPISYEDIELSDCIFIAGANPAWCHPILFRRIEKHKADNPDVKIIVVDPRVTDSCGLADLHLQVQPGTDMFLFHAIGKYLIEQNMVDEEFIRKHTNGFEAYAHEIKSRSLQEYAAICRVPIDSIIEAARIIGQSKGFITMWAMGLNQSTAGVNQNLALINLSLITGKIGKPGCGPFSLTGQPNAMGGREVGGLSNLLAAHRNLANPTHRKEVADFWGVDAIQGKPGLTATEMFESLKSGKMKAIWIICTNPSVSMPNARLVDEALKAAKFVIVQDISRKSDTTQYADLLLPAASWLEKEGTMTNSERRISHLAKVVDAPGMALPDSEILIRFAKAMGFHGFDFNNPAEVYEEYTRLTKGTSIDVSGLSYHKLKRAGSIQWPVPSSDHPGTPRLFENGKFLTQDQRANILGTGAQTAHEEPSEDYPLILTTGRIRDQWHTMTKTGKVAKLKKHIDRPFLEIHPDDADFRDIRDGDPVRIYNDRGDVQVAAKVTASIKKGVVFLPMHWGKKLNIDLSRANNLTSEAVDPKSKQPGFKFSAVEVLRHLIPRRKIVVIGAGAAAYRFVNTYRDFNQEDEIHVFSKEKWPFYNRVLLPDYVNETKKWEDLVKYTEAELEALNLHLHPANPIIRINREDKTLVDDRGDTHSYDLLIMATGSRAFIPPNAPMHLPGVFTMRDRENADDLKKQLCPGSNVLVIGGGLLGLELAAAFTEMQVSGTIVQLGSRLMERQLDPMASAMLREYVQDLGVRIFTNDEVVDITENEDKLLQVTLKSGNSLLMNAVVYAIGTRPNTQLAIDAGLKCGRGVKVNDYLQSSDPDIFALGEIAEHNQRMNGITAAAEQQADICARYLAGDPSHHYSGTTPMNILKFPSLDLCSVGTPEIPVNGKNYSEITFLDREALYYKKCIIHNDKLVGTILMGDKAEFAEYKELIESGTELSDKRLQLLRSGGTPEPVKGKLVCSCNNVGEGNLLESIALGNDTLNKLCQASGAGLGCGSCKSEVKRLIDRSLEAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG5</accession>
    <name>A0A654DYG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28455" checksum="FAB960C35EB71E9A" modified="2020-04-22" version="1">MEKIRVLIIEDEADQADELKVFLEKGGYSVCGIADNLTEGLGLFYALKPDLVVADIYLKGNPEGISFAERMGENMNTARPLIFLTQHADFETFRQAKLVSPYSYLLKPFNPLELQYAIELAMEKFASQPGGLSIKENALLMEESLFVKHKQSLIKIPISNIEYVEVDGKYCKINAREGSFLVQLSLVKMEEKLQAYHFLRIHRNYIINLNEIRQIHLTDNQVILNGERALPVSHTYKDILMKRFDVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH7</accession>
    <name>A0A654DYH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_12099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="31996" checksum="D388C217160B730B" modified="2020-04-22" version="1">MSGYFKNIKEAFSTMSEGLKLTFGYLADARKSRTPIGVADEKYFDADKGIVTLEYPYESLPVPDNARYRLHNEIDDCIVCDKCAKVCPVDCIEIDPILAPETFGMTSDGTPKRIHAAKFDIDMSKCCFCGLCTTVCPTECLTMTKVYDFSEFDVNDHVYSFAEMSLAEIAQKRKELAEFEEKKAAAKAAAKGDSEREPVKAKAVMRPKPMAPKPAGAKPVMKPKPAANEEQSTKPAETEKPRPVMKKPAMKPVLKPKAAGGETDKPENKPKFKPRPMIPKKPKDDDGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP9</accession>
    <name>A0A654DYP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="5286" checksum="A22E8412530C4E80" modified="2020-04-22" version="1">MDESQLIEYSTYLSHEVYNINMLCSTREYHSGMGTAIQNWCDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ5</accession>
    <name>A0A654DYQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="27132" checksum="8501EC3E430FD54D" modified="2020-04-22" version="1">MPLWWLGRFATFLLSISSGHTADSWLAATSVTQEMINWLKYLRNEFGKKSFLNRFIVPTAGIFFTWGFLGHLYMTNFQLNDLTPLEGRITYIDIVPEKSISQSGGTYHPLMIRLDTGSELYRLHEEFKFKFDELLNQVSEGDVVTLYKRNRTQAFLTWGRGNDIFQIDSNNTTLFKLEWMLNYKKNQMATFGIFAVICWIAYSVYWIERTRNKKVAAKSRSCPPPPKSKYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR5</accession>
    <name>A0A654DYR5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024971735" description="PKD domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="32708" checksum="4C8377330487A90A" modified="2020-04-22" version="1">MKTQSFKKLMLLGLTAGLAGLFSCGEDEAKTPLPVADFTFTLEGKTVTVVNASTDAETQTWDFGDGATSTDLNPSHTYEANGSYIVKLTVTNETGSDDKSEVLEVINIQIDGDLSDWDDVPALATYGDGEAGSFLEVKVENLEDDKLFIYVKTTSASNGFIDLFMNSDNDDATGFASWMYPTTPGFDILVEGYAISQSAVEAELFFGNYDDATAGEDKTAWAWTALTPSANFFKTIELQSAGANKAYEFSVDLSEFPPAAAASGSVKFFLIDVDAPDGAGSDWAWLGNAPAGYGEETSAAFTYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS1</accession>
    <name>A0A654DYS1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032267">
        <property type="entry name" value="DUF4832"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032379">
        <property type="entry name" value="DUF4874"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16116">
        <property type="entry name" value="DUF4832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16173">
        <property type="entry name" value="DUF4874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="726"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="893" mass="99846" checksum="74CD95E44D5BE107" modified="2020-04-22" version="1">MSPIQRIVTCSLLFIALTGYSQTVTYTSDESVIANPERGFYHHTEVHTGQYENLNTETLKGYRTNEGITQILRVFYLENFRESPISGDYLNNMRRDFAIARSAGIKVIVRFAYSQGTTAPYNDARPEFVQTHIDQLKPVLRENADVIAVMQAGFIGTWGEWYYTDHFANSPGQISTEDWENRRQVVYSLLDALPDDRMVQLRTPGYKFTIFDSQEPLNETTAFSGSYASRVGHHNDCFVASSSDFGTYVNPGIEKPYLREETRFTPMGGETCALASPYSDCENSLSDLEQFHWSYLNIDYNRQVLSEWDNQGCFDEVELRLGYRFKMIAGTFTTATKPSGKFAFSLTLQNDGFSNPYNPRLIEVILKNTTTDAEYLIQPDENIKLWPLNEAFNLTFEAGIPADMTDGDYQLYLNLPDPYPSLYKNPAYAIRLANESTWDSETGYNNLLSTVSISASNSSEDYTGSDYFTPRLTQSTIEVEGADQIFGAASNNATLTYWGRQSNDLMRVIERSTDTGSFETIASISAAQDYFLDLNVAPGTNYTYRYYLSSATGSTSPSAEITLTLSEESYPTIVIDGESSDWNTITPVSSTVSDAEAKVLRVFFGAQSAFVLLEGEANNYSIYLDTDNDLSTGFQDNTGPLSGMDYQLTENGLSEYSSNQWTTTNASINKATGDKTTELSIPLDALENLGDNRNLRIYASLNNGTALLSNTEGQPTNLYRALPPAIPGDFSVRNSTELPETRLVVSWSACANCLGYTLERSQDGETFDLIGTYDTSVSLIRDDNLTNMVTYYYRIASYNELGTSAYSETVNATTGVIQLSTQPELPVLFPNPAQDRLFISTLYDQFAIYSLDGALISKGDYQKSIDLRMLRAGMYVLHIQTEEGSKQLKFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU4</accession>
    <name>A0A654DYU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16577" checksum="0DE326052BFD89BA" modified="2020-04-22" version="1">MIRVITANTEELKEKAFAIRREVFVVEQKVSTRDEFDEFEATSTHFVALDENEQPVGAARWRRTEKGIKLERFAVKANQRGKQIGSKLVEAVIADIRSKEGSGQYLYLHAQLTAVPLYEKFGFEKKGDQFSECDILHYLMFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ19</accession>
    <name>A0A654DZ19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128417" checksum="A08905F056D4F9CE" modified="2020-04-22" version="1">MKRNRPYLAVQNNYFFVCLGAFIIGVFMSSGLLAQQYNLPTVPTPTAYSFVRFNDISISHHSGTPNIEVPLYTIDDGDVKIPISLRYAGGGIRVNEEASWVGLGWNLNVGGVIVRSVKGQIDETCTIGTIPGSYDPDALFTEPYTENQAWVGKTSTELYNEQGFNPYDSYCSSEYQNLLYLGYFEPDVFTFQFMGYSGSFIYDESAQDFVILNSNEPLKIEMISGSYGYYDIGAGYKITTSEGVVYEFDRREIKYPVDDFSRIVSESFYLTKILYTDGSYAKFDYETLGNAVSNFQSLDQYRGYTVGLGSSNPEWRNKSSYDSYQPVYLTEIETNNFIADFSNRSSRIDIYGEEKLDRFTITDKVTNLVRGFNFQYSNSLATNFGVKFGSSWHANFNENHIKYRLILNQVWQDGLSPYEFIYNTKKLPYKTSYAVDHWGFYNEVNNSYFFPNLSAIVNSEFRYNEDPSLQDPFNDNPPIGMKFRGFANRGSNEEAMKAEILEKIIYPTKGHAEYEWGSHEFTNHSIPDSDYQGTEVLGNFGVKDSNGADGDDVTARNNFPAGGNKAQITITFSVGQVDCGAGQNYTLARNTHIDVLDNAHIQLRSGTYGTTLEKTWTIPDEVFYGGYDDFPWTYTIQEEISLNPSVATYFLSPNLPSLTSQQITDNCGKSKNYGFHVRATLTLLDDKGEFLASSSNPSRGGGLRINGIGIYNPADPTPRIQRTYTYNEGKLNLPLSYFTHEFNNHLTYTNGQINSMPSAEWWFNTKSNANFYAGSQPLVSYGYVEENQLPSNGSIIYEFKNVDPKFGPNNNLHPFHASYESGLIERKTFRNAAGEDVKIISYTYDDLLSDGAYGAMGIFEYQALSGQQPNIEVRRWYTYKFFFDHWVNTKTVVIDLNPTNTFTNTIINKHNSLGQVIRTVSFGTDSLVDKQVSIFKYPNELKGGSSFYQTMFDRNFHPVVEQENYHNQTLSLKVKTNFESESFTQNGENYFGYYPTNRLTYPTGGAEVSTTTINYDHGKMIELTGPDQVLNVFLWDGNQLVARGINTTFNEFWDAYFIDCGYGDYSCLKSQQPNARFSLYEYEPINGPTKITDENGLYTEYVYDTFGRLLRIKDHDGNVLEEYTYNYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ1</accession>
    <name>A0A654DZJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein involved in gliding motility GldA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="302" mass="33483" checksum="B7FA46CF81BD624A" modified="2020-04-22" version="1">MAVSIQQLTKVFGTQRAVSDISFEAEKGRITGFLGPNGAGKSTTMKMATGYIRPTAGQVLIEGLDVTDHPLQTKALTGYLPEHNSLYLDMYVREFLRFIASAYGLKSAGKRVDEMIELVGLQRERGKRLSALSKGYRQRVGLAKALIHNPKVLILDEPTSGLDPNQILEIRQVIKDISVDKTVILSTHIMQEVEAICDHVVIIDRGELVANDQLSVLKEGLNHTNGIIIEFEQPVDQSVFIQAGFEPQPFGASAYLIESDRSDLRAELLRITSENDLPLVSLTKSQQSLEEIFHRLTQKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK5</accession>
    <name>A0A654DZK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="362"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="581" mass="65818" checksum="18A169DC5A9D580F" modified="2020-04-22" version="1">MDYEEKIKVLKSILLHSVNNDDSTIFYGNRLLQEAHETDHSNKFWANVYLGQAYKSQGSYESALEYLFEALRIGDHLTKKDVAMVNSLIGTLYGKIGDVEKLAHYFSLCIGQYETGDYQDSIRQVIAYNNLAEGYYNNDYLDSSLKYYQKAEFFAQELKREYLTKVITGNIGMVNARLGNLDLAEEQLSNALEYKSSMGNDAGTITTYQFHLADVYFQKNRIDQARDLVEEALALAHQRGLKEQISDGSLKMSEFYTHVGDFEKALQFYQQHIVYRDSIRNLAMIQNLADMRTRYEVGQKQAEVDVLTAEKRIQQLIMLAIGAFALVLVVLAGIIYKYYQTKSRINRELESLNQTKDKFFSIISHDLRGPVSSFFGISRMIKFLVQTKETDQLMVIADDIDESVERLSNLLDNLLTWAMQQQGHFPNNPERLSLGEMAEEIVKTLGNMAKAKNVELSTRVEENLEVWADKNMTMTILRNLVNNALKFTPEKGQVRISAKTVNGLAVIRIADSGVGIPKSKLDTLFKFHDKKSTYGTAGEKGLGLGLQLVHEFVEINGGSIDVETAESMGTTFIVRLPLPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL0</accession>
    <name>A0A654DZL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="28508" checksum="BB0CCC596BCF0D8D" modified="2020-04-22" version="1">MKLDQLINRRSVILFSLFFVMAVVAFWGSYFARLTAQTDYRLHAHGIGMILWCMLLITQAYLIRTHRRGLHKRLGWLSYLLIPYIVFTTLNLIHFQMRGLDRVTNLPMYALALIINAIIVFVIIYGLAIYHRKRPLVHARYMLATIFPMFTPVTDRLIYGYFRPLIEWVPRIDHAPIVPVIGFALADIIVVGLAIWDWYAHRRWNVFPVVLVLLLIYHYSVLNFYRFEFWRSLCEWFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL3</accession>
    <name>A0A654DZL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024812312" evidence="1">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="20926" checksum="099CFE8DBA2DF99A" modified="2020-04-22" version="1">MNTKQILSAFILFTFSIGGVLASDNQKDEKTEADLSASSIHYPVKPSLAINTSSYNTAFGVRGLGTSGLTIKHFTSNSTAIEGIIGLWPSALSATILFERYVNAFDEPGLNWYYGIGGHIATQTDWVYYDGVRGYRRSNGDFGVGIDGIFGLEYKINEVPIAVSLDVKPFLEVTTNGDAYLALDPGLGIKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ0</accession>
    <name>A0A654DZQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="416" mass="47823" checksum="CD8FBCCD61874955" modified="2020-04-22" version="1">MRIRTVLTVIWIFYITICYSQIDYNKKIINGDNVSLSIENDDVKVNFIKSIIRGYRLETSKALLADSVARFLQLLEVNTANINNEEYLIFSNPEFEIGNLVAGNYQIILDQLIQYPEINKWGYRHPKNEGVITYFYDDNLYEDFSKILIAKEGVITSEINQFNDEQKHILEIYLTYQLALQDINQNSIFEALFSQVELFRRNYPNSIYTGFTDEIKGLNYTTSDIGFASMLSTGVYIPTEGLNNHFSFSIPINGALEGKYKFLTFSLGFGYGIGQKVQKEFEADTLWKKDTNTGLGMGEVLLGVNVLRTERVNISLKGGFRGFGIVPPGTDRFENMENITSTNDLTYGIGVDYKWEPKNKPIYSIKSKSSELRNFIRINLFYQNPTFEKKVSTFNGAIYHLRIAFGQQIFFPRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ5</accession>
    <name>A0A654DZQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010538">
        <property type="entry name" value="DHOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06537">
        <property type="entry name" value="DHOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="51"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="264"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="43049" checksum="B5A09579EF1736D6" modified="2020-04-22" version="1">MKHSQLLITICCMILLGSCESLIPPAPEESELLDGPMTELTPAQNRQFLAGDIAFNDEVFTALNGLGPLFVATSCGSCHAGDGKGHPFTTLTRFGQTAPDTPHQSPGAPQLQHRALPGFEPERIPEGTPYMNFTPPAVTGLGLLSAITDAQILDNADPDDLDNDGISGVPNYVSPPPYFEQQWFHSPLNGKIIGRFGKKAAAVDLLHQTVSAYNQDMGITSTFEPTDTYTGLTLDPEVSDKTVRDVVFYLRTLKAPIPRNAQESIITSGRKIFENINCSGCHIPEWKTPSSDIEALSNKLFYPYTDLLLHDMGPELDDGVTEGSAETYEWRTPPLWGLGLSPNSQGGQYFLMHDGRAKSIAEAINMHGGEAEQSKLAFQALAESDQEALLKFLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT9</accession>
    <name>A0A654DZT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8601" checksum="169FDC017D42169A" modified="2020-04-22" version="1">MIWIKNLRTGVLVLVLLVSGLAFSGCHASYYKIPITKSRKHFRPYDDKKDRGKKRVHIKKYKSLNRTKKINDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU4</accession>
    <name>A0A654DZU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxA</name>
        <name evidence="3" type="ORF">MARINOS108_120226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.262" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="37608" checksum="176B45345831F764" modified="2020-04-22" version="1">MSDTSQNRENKPIIGISIGDFNGIGPEVVIKALNDNRILRHLTPVIYADGRVISFYRKQLDLQNFTYNQTKSIESIHQRKVNVLNLNEQEIEITPGEPGKSGGEYAIASLRRALEDLKSGKIHAIATAPLSKEMVQSDDFKFPGHTEFLTQEDGAKDSLMFLVAEGLRVGVVTGHIPLKEVAQAVTQERIEAKLNLMIKSLKKDFGIKKPRIAVLGLNPHAGENGLLGEEEEKIISPSIKTFKDKGNLVFGPYPADGFFGTNQFRSFDGILAMYHDQGLIPFKNMAFDTGVNFTAGLSFIRTSPDHGTGFPIAGKGEASETSMRNAIYMAADIFKNRSEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ3</accession>
    <name>A0A654DZZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Linoleoyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="371" mass="43068" checksum="328311EF3E101D7B" modified="2020-04-22" version="1">MSQPSVKFNAQDRPEFFKELRKRVNAHFKENNISRHANLEMKFKTAFMIALYFTPMILMITGVVTSLWGVIGMWTLMGIGMSGIGLSIMHDANHGAYSQNKHVNNVLGYLLNFLGAYHTNWKIQHNVLHHSFTNVDGHDEDIAKEGVMRFSPTQERKSIYRFQVFYAPFLYGIMTIYWFLSKDFEQVIRYHKRDLLAPQGYTFASALAEVIFNKVWYLAIFLALPIIVIALPWWQVLLGFLLMHFISGLFLALIFQPAHVIHETNFYVPDENGSIENNWAVHQLRTTANFANKSVFFSWFVGGLNFQIEHHLFPHICHVHYRHISAIVKQTAEEYDVPYHQHRTFLDALRSHFSLLHQLGTGSYDKKLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ9</accession>
    <name>A0A654DZZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Citrate lyase ACP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023439">
        <property type="entry name" value="Mal_deCO2ase/Cit_lyase_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06857">
        <property type="entry name" value="ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="114"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="403" mass="44112" checksum="E73617C30242713A" modified="2020-04-22" version="1">MIATAGNNGEKDRSDCLVTLELVQSGGIRIEVLSKVNALYGEDIRLLCKSILDFFSIEHAVLEVSDKGALPFVIAARVEAAIKQLKPTDEQYLLEMLPENLYHTVADQPRITRLYLPGNTPSLMINAGIHKPEGVILDLEDAVAFHKKGEARLLVRNALRNLSFMGVERMVRINQIPAGLEDLDYVVPHNVNLVLVPKCESAAQIHSVNERIVLIQNKTGIQRPVWLMPIIESALGVLNSFEIAKAAENVVAMAIGLEDYAADMGVNRTNEGVESLFARVQVVHACKAARIQAIDSVFSDVGDMIALKANVQASKALGFEGMGCIHPRQISIIRENFAPNEVEIEAAKKIVKAFKIASEKGLGVVSLGTKMIDAPVVKRAMRTIDLAVALGRLEKNWSDKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J1</accession>
    <name>A0A654E0J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHASE2 domain-containing sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="415" mass="46955" checksum="C38A7A1D41EE2D9C" modified="2020-04-22" version="1">MFRKFWLDVILGTAFIFGMMGVFQSFTAFKVFDVFDPIGQAFGDMEFTDIVFSQLRDDPVGDDRVVLVNLSNLQRGEIGMMLQIISQHNPAVIGIDSFFYTPKEDTLGDMMLMEGMASVEHLVLASKLLPDPTDPTKDTIEYSWELFNSFAERTAFVNLVTDAEVQEDLKMCREFYPKFDIGGEQQIAFAVQLASYLDSAAAADFLARNNETEVINYRGNVLDYGATKFGNKYFALDVPDVFGENFVPDMIEGKIVMFCYLGKHLGDRESFEDKFYTPLNQKYIGRAFPDMYGGVVHANIISMILNRDYINSMSENMGYVFAILICFFNVALFSLVYKKIPKWYDGITKLFQLLEIGVLVFGVIYILELYSFKADIAVGMVAVALAGDALEVYYGVVKNSFTKEGRKSLFKVDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L0</accession>
    <name>A0A654E0L0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">rplX</name>
        <name evidence="5" type="ORF">MARINOS108_120486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="12519" checksum="F39741EA9058A050" modified="2020-04-22" version="1">MMNNHKANKFHIRKGDTVKVLAGNDKDKTGKVLEVISEKYRAIVEGVNIVTKHKKPSATSPEGGREQTEAPVHMSNLMVVDPATGEATRSGRKLNESGKLQRYSKKTGEFITNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V7</accession>
    <name>A0A654E0V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RND transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="481" mass="54201" checksum="F6E04D27191AF9CA" modified="2020-04-22" version="1">MTTALSKTIYKYLGIASFVVSVTACTPDLAMKKTANTALPEAYKSSQDTTNATTRINWREYFTDPNLIALIDTALNNNQELNITLQEIEIARNEVMARKGEYLPFVGLGAGAGADKVGRYTRNGALEANNDIKPGKEFPEPLGDFMVGAYATWELDVWRKLRNAKKSAYTHYLSTVDGKNFMVTNLIAEIANSYYELLALDNQLRIVQQNIEIQSNALEIVKLQKEATRVTELAVRRFEAQVLDTRSLQYGIQQQIIETENRINFLVGRYPQPVLRDSEVFIGLMPDSIQLGIPAQLLENRPDVRQAELELEAAKLDVKVAKARFYPVVGITAGIGYQAFNPTYLVKTPESLIYSLAGDLAAPLINRNAIKATYYNANAKQIQAVYNYERTILNAYIEVANQLSNINNLRSSYELKERQVQALTESIEISSTLFRSARADYMEVLLTQRDALESRFDLIETKMQQMHAWIDIYQALGGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E103</accession>
    <name>A0A654E103_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024914259" evidence="1">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="22019" checksum="686B153B03D1C239" modified="2020-04-22" version="1">MKLFLILILLAISAPLLAQSPVESQMYAKMDQAAELMEQGKYEEANEVYLYVLKHMTALPSDLAFYFGKNSYHLDKYKQSINWLNKYIQLKGTQGRFYDEAVKYLQYSEEEYLKIAQQNTADLKSDLSGEDYDCGGLEKMICPVCRGQGVVIKQGPFDLIYKTCPYSAGEPYLTCEEYNLFMKGQLEPKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E147</accession>
    <name>A0A654E147_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="134"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="502" mass="56833" checksum="BE9CA77B0091EDE3" modified="2020-04-22" version="1">MKSLSSFLIVLAVLIGCSPKSTDVKEQTDSGPFLHGVASGDPLYDRVIIWTRVTPESPADSVVVSWEVSEDQWFKSSLISGQVVTDAGRDFTVKVDVANLQSGTPYYYRFKSAGSFSPIGRTKTAAQNADSLRFAVVSCSNYEWGYFTAYQKIAEKELLDAVVHLGDYIYEYAPGGYGDTTIGRKHEPPHELLTLSDYRTRYAQYRSDPDLQAMHASHPFIAIWDDHEIANDVYTSGAQNHQEHEGSFEERKRAAVQTYYEWMPIREADKLYRSFEFGELAELIMLDERLEGRTAPVASISDENFNSPDRSMLGADQLSWLKSTIEGSEARWKVIGNQVIFSDINQTMVFPDNPKNLDSWDGYPAEKKEVARFIKDFDNILWVTGDTHASWVMETIVADVSLAPLGVEFGTPSISSANYDEYSGLDTARMYENLFQNFNPHIKYANLTEHGYFLLTLQKERATARYYFVENIRVPNAAEGRPKEFWVNDGAPVIKQYNVYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E169</accession>
    <name>A0A654E169_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Do/DeqQ family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="485" mass="53249" checksum="5E625184A290DEF4" modified="2020-04-22" version="1">MKKTIVIVGCVSILSGIIGSLLTFTLLKKEGFLSTEHASLISLNHETPDLGFTPQYSEIRPEVINAEDNFVFASEQSKSSVVFIQTLSEYEYRTGSWLDWFFEPRASQQISSGSGVILSEDGYIITNNHVVDDADIIKVVHGKKTYDGKLMGTDPSTDLAVIKVNQQNLPAIKFGNSDDVNVGEWVLAVGNPFNLTSTVTAGIVSAKGRNINILRDKFPIESFIQTDAAINPGNSGGALVNTQGNLIGINTAILSRTGSYTGYGFAVPSNIVKKVFEDIKNYGEVQKAFIGAEFIDINSELATKMNLEDLSGVIVANVQREGAAAKGNLEKGDVIREINGRKIDSKAFLEEYMGNMYPGEEIKVLIEREGTKKEKKLTLTNREGTTGIIRRDVYASEWLDATFESVPKVERDLLGIKSGVKVVDYKKTGIFAKLGIAEGFIITHINNTTVESPAEFSEILERIKGRVIISGIDKHGRNVYYPYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E181</accession>
    <name>A0A654E181_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025515">
        <property type="entry name" value="DUF4403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14356">
        <property type="entry name" value="DUF4403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="478" mass="54351" checksum="735AE83FB87990A7" modified="2020-04-22" version="1">MIEFLSFFFHFQNQRMRKICLYLVLLGALMACDRSTKKESEAALPPLQTLPSYLSFRVNFPVGELEDGVNRVLPKLILDDALPLKGKGDTLFLKVERKGKLNLAIRKNEIFASIPLDVEAGISKKVLGVTFSNADAPVKFSGLLKASATVGIDENWDMNVTCEYKGFDLGESSKISIMGMTFNVEGTIDKALEEHEDQLSDIICGALNKAVDFRGTVEKVWMDLQKPQRIAKRPQELWLYSNPVALNGTLVPLEKDTLSVHVEFRTKINISPIKRDVEVKVPLTSRGEPLNTRAALLVYPEINLPYDLLSQTLKRELAQHEFTYEAYKVRVTDAQIMREGQKLKVKLNTTGDLNGIVYATGRPVLNEDRELVLEGFAYEIDADDEWVAMTDWAVHEFAERYVAEQVRMDMQPFLEDLDELIMTGLDKSHLAEKLDLQIGFDEVTSYQLRLTEDAIQWIFYLEGWSQLNLKKGLFKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D6</accession>
    <name>A0A654E1D6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SiaC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16785" checksum="3ABC2690A0D15B78" modified="2020-04-22" version="1">MTVNQHSSRPYNLDSLSLMVSHFGTRVIEPTPKTPFVCYDEFNQVLMVKGNSTNPDMQKFYHEILTDVKANLEETDQLTVSFYFQNINTSTAKVLFDFFKYLRSMRAVGKRIHVIWSAEADNEMMETGRDFAEIYDMDFHYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H3</accession>
    <name>A0A654E1H3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="367" mass="40736" checksum="72589A413CDED562" modified="2020-04-22" version="1">MKRFAAFVTKEFYHILRDKRTLVILIGMPTVMIMLFGFAITNELKEARVAFLDHSNDPQTLAIQEKILASPYFSLSGQISSPTGIEDIFRDGQTKLVMVFESDFGQRLEKDGQANIQLIADATDPNTASTVVNYAQAIILDYTRNIIPQQSTPLINVQSQMRYNPELNGVYYFVPGLIAILLMLVSAMMTSISIAREKETGTMEVLLASPMKPAQIILAKVVPYVLLSFLDAVLILTLGKFVFGVPILGSLGLLLGVTLLFILLALSLGILISTVSPNQQTALLLSLMGLMLPTILLSGFIFPIENMPLLLQVISNIIPARWFIIAVKSIMLKGSGFLLLWKEILIMFGFILFFIAVSVRKFKIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I4</accession>
    <name>A0A654E1I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase pif1</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pif</name>
        <name evidence="2" type="ORF">MARINOS108_120465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="572" mass="64681" checksum="C2754E5E5A3ED689" modified="2020-04-22" version="1">MNQETALAILKTGQNVYLTGSAGTGKTYLINQYIEYLRVREVPLAITASTGIAATHIGGQTIHSWSGIGIREEITPKDLDQIAKNRQTVTRIKAVHVLIIDEISMLSGKVLTGISDILKHFRKSKAPFGGVQVILSGDFFQLPPVSRTPMTNREKFAFMAPVWVEAKLKICYLKQQFRQGQDTLSFILSEIRSQDVSDDSLEKLREKLEDTQTIPDALRLYTHNADVDAMNAKRLEENPNPIQVFYAETKGKSKILEGLKQSVLAAPALELKEDARVMFVKNNPEKGYFNGSTGTVMGFDREEGYPIVNMDSGRTVVAKPEEWTVSDEKETILASYKQIPLRLAWAITVHKSQGMTLDNAEMDLSKTFEAGQGYVALSRLKSWEGLVLGGINRISMELDPLAVKADNRFQELSEESEDWLNHIPKDELNIAFLDFISRSNGTNDEETIQANLKREKKYHTKEKKESTYQKTLKLIGEGKTLEEIAFERELSLGTIVGHLERIAEEEKEIDLSKFKPDDKTVAKVEKIIQKLKDQNQEEFYDKDGRVKLGFIFKAMNGQMDYETIRLTRLFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M2</accession>
    <name>A0A654E1M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="334"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="49209" checksum="746845BC7643F8F6" modified="2020-04-22" version="1">MIHQSLGIGGYLLFEDYMLLTWLRFIPFSKRLLLVLILGCMMGTRASSQERIGFFMPDGVNMVEIKFEQYSNLIVIPITINNFLTLKFILDTGAESAILTEKVFGDILGLTYVRDIQIQGPGLIDSLQAFVATGIRMSMPGGIQGKGLNMLVLKEDYLELNKNLGEEIYGIIGYEVFNRFVINIDYDERILRIYRPESFKPRKWDTAIPMTVYNTKPFINMQITQDGKKDTVKLMVDSGASHALLLDVDNTDDLKRPEKVILTRLGHGLGGEIPGHLGRMNTCLIGDFSFEDVLVSIPISGAYIKAIKRGSRHGTLGGDLLSRFDVTFDYPNETLYLRKGQTFNDAFEANMSGMIIAAEGKKLDSLVVSDVNEDTPATEVDIRRGDVILKINGLNLQNSSVSEINAMLRKKDGLKIRLVIWRDGRKMKKTFRLKRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z8</accession>
    <name>A0A654E1Z8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LMWPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17461" checksum="75F7B0298C8BDB6E" modified="2020-04-22" version="1">MLNILFVCLGNICRSPLAEAIFNQKVKERGLNQSIKADSAGTASYHIGEDPDSRSIQVAVKHGVPIVHKGRQYHFKDAATFDYILAMDASNHRDIIHATSDRPEGLFLMRDFDPEGQGGDVPDPYYGGEDGFEKVFQILDRSIDAFLDFLVEKHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E258</accession>
    <name>A0A654E258_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="169"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="412" mass="46271" checksum="4AF0D45FC141B8B2" modified="2020-04-22" version="1">MVAYKEHTLPNGLQLIVHEDHSSPVVCLNILYKVGSRNELPHKTGFAHLFEHLMFGGSKNVKNFDEPLQAVGGDNNAFTNTDITNYYITIPSANVETAFWLESDRMLSLSFDPEVLEVQRKVVIEEFKQRYLNQPYGDVWLKLRPLAYQKHPYQWPTIGKEISHIEEATMEDVKSFFNAHYHPGNAVLVVAGDISEEKALELTQKWFGEIPGKPMSNGRIEAEPPQTAPRFMEVADNVPADAIYKTYHMPRRLGKAYHAADLLSDILGRGKSAILFNELVKKKPLFSSLSAHVTGSYDPGLLVITGRLLPGVALKDADLAIQEHLEPVKQHIDSELLQKVKNQAEATTVFAEVDLLNRAMGLAFAAFLGDANLINEELDQIKSLEAEDLLESARTILRADNCTTMYYQKRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E282</accession>
    <name>A0A654E282_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="341"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="716" mass="78619" checksum="9CE0160E4DFB6321" modified="2020-04-22" version="1">MALINTLRKRMGKVVVGFVAFSMFAFILTDLFQSNSVLLGGNDTTIAEIAGKDISYEQFQAKVSELSYIFAINNQREPSSDEIETIRVQAWNALILDYAYKGQYDELGITVTNSEVVDMVQGNNIDPQIKQFFSDPNTGEFSRENVVSFLQQLNSAPAQQRASWLSFEDRLKPNRLVKKYENLLALTNYVTTAEAKSKYEAQGTNMSVDYFYVPFFSVADSLFTVSESEMKSYLSANSEQYQREESRSLNYVVFPIQPSADDSAFVKEEITRLREGLINSQNDSTFANMNSDGLSPFRSISDPGLLPVGLVGAEVGTVTEPTLVGDKYAISKLSDITEGDEAFVKARHILIEMDGNSESAKAEARGKANDIISQLKKGADFAELAAINSADKSNANNGGDLGWFGENGNFVQPFKDAVFAHRGTGLLPNPVETSFGYHIIQIDEPKTKTVYKVATIEKELFESDATLNEIYRQADLLAANSSDAASLAENAKEAGLSVRSASAIGKNDSRVGVLTDARNIVLWLYNEASVNKVSDVKEFDDQYVVAVMTARQPKGTATLAQVENEIRTKVLNEKKAKYIKDKIAGLSASDFEGMKAEYGDKARTGSADLTLNSNSFPSVGFAPEAVGVAFSLDEGEKTAPFETSNGVLVVSATAKSTPEPLDEYVSYKTQVATERQGRKTVIANFPLSFTPVFVSQSLDNAIKEFAEIEDNRYKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C0</accession>
    <name>A0A654E2C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="50130" checksum="06349E15E3A946EF" modified="2020-04-22" version="1">MKVNLSWLRATFWLVGSMVYPLVSGAQDENKMESATLEEVVAYALKHQPGVQQAEINQEIVNQAVKGKLADWYPQISFNYNYQRFIDLQSSVIGGEVIRFGVNNTSSAQLTATQSLFNRDVLLASNTASTVRLQAEQGTQQAKIQMVVNVSKAFYDLLATQKQIEVSEESVIRLESSLKDARSRYEAGVADKTDYQRATIALGNAQAAYKANQELLGYKQQNLKTLMGYPLEEELPIAYDVDMMENEILLDTSEQMNPVNHINFRLLQTQRELQEANVKYNQWAFLPSLSAFGAYNLNYQNDNFGELYNTSYPYSYVGATLSLPLFQGGKRLSKIQEQKWTSDRLDVGIADLKNKLDTEYDRALAAYKSNLYSYLAQKKNVELAQEVYDIIQLQYQSGVKTYLDVTIAETDLRTTRINYFNALYQVLASKIDVNRALGTINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q6</accession>
    <name>A0A654E2Q6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">coaX</name>
        <name evidence="7" type="ORF">MARINOS108_20363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="26745" checksum="3CEB85D23360E048" modified="2020-04-22" version="1">MENEGNVVVDIGNSKIKTAIFEGERLVSRFAADHLEEVFQHYEKASYRWIFSSVGDDPSAHSRISALKDHLILSRDTPLPVSLDYQTPETLGVDRIAASVGAFHLYKKSCLVIDAGTCITYDLVDKTGVYRGGAIAPGLKMRMKAMSHFTKRLPDVSAEWEEIPLKTQGKTTRECLVTGAFDGVVHEMDGFIEAFLKEYEDLAVILTGGDANYFESKLKAPIFADFDLVLTGLNTILNYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q8</accession>
    <name>A0A654E2Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024976142" evidence="1">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="128"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="27821" checksum="6ABC61B78ECEFA97" modified="2020-04-22" version="1">MKRVYTLTLLMSLVALAAHAQQYKYTPKGNIAETIVVIQNLYADISIEGVSGNEITIETDEYEGIPEKAKGLKPLSATGPENTGIGLSVVQEGNKITISGASRKADGEYRIKLPKNMMLRADLNSWQSGDFYARGLTNEVEVKSQNGDLIFEDITGPLVAYSLSSDISVRFSSLNQTTPTSISSTSGDLDITLPASSKGNFKLSSVSGEIYTDVDFKFGDEKDLKRWGGGMSANATLNGGGVEVSLKSISGDVYIRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z9</accession>
    <name>A0A654E2Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024941257" evidence="1">
        <location>
            <begin position="22"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="367" mass="41836" checksum="0DC897DED48276BF" modified="2020-04-22" version="1">MVIKRGIILFISFFLFQQAYTQPEMVNVGGASIINISNQLPENLTSERSVVILDIPTQMKDGFVIRGDWKKLAANAHKTFRKIGVDPIAYVYLDDLNAGPEVNSAYLSLFQKRNVKNLIIINQVGQFPEETYTMVITGFSAENYIKNGQNGWKESDPELNQVMVRLGRQVLRQKIERSNLLIPEQPEYLQDLVIFEGTRLENYPSRLKSLKLAVVAFQKVPADNVEDAELASKIAAYNQQVEEKNKRLDAIMAAYPFKYDIVTETNEDALYKAGYQYALMPLSSTGHSVKKVLNYPTTATETHYMTSTFDVQSRPALKRIPINANVTKYYIKQTIVKDIHPGKVWDADVSWEQGLENFIYNLNQAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B2</accession>
    <name>A0A654E3B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="97" mass="11113" checksum="D1329C7BF78DC8DE" modified="2020-04-22" version="1">MHFGEQIKQLREKRGLLQRQLAASLEIDTPMFSKIERGDRRAKREHVVQLAELLDFDVNQLLSLWLSDQILDIVSSEEVALEALQNAATTLKKNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F2</accession>
    <name>A0A654E3F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="205" mass="22752" checksum="D558F6AFF71F5286" modified="2020-04-22" version="1">MSTQVFIIAFVVSYLGSIPPGTINITSMQLSVQNHRRAAFFFALAASITEFIYAGVTVRLQLFLSEKPFFTEYFQIITALAMLALGVANLLTKTNSQSLLSKTTTPKGRNGFKLGVILGVLNPLTIPFWLAVTAYLQNHRLISLSGVNFWLYLSGISIGTFALLLTVNRLGARFTNIADNQLLVHRLPGIIFILLGLYNFIDWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H4</accession>
    <name>A0A654E3H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025563">
        <property type="entry name" value="DUF4286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14114">
        <property type="entry name" value="DUF4286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="11713" checksum="DFDA2DE6438B9659" modified="2020-04-22" version="1">MIVYNVTVNIETEVESDWLSWMKQTHIPEVLQTGCFTEHRFLKLLNDDPEATGTTYAVQYFAPGITSLNNYLDNFAPGLQKKVIDRYSNKFVAFRTFLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I4</accession>
    <name>A0A654E3I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15121" checksum="3916FC0B5A82BBE2" modified="2020-04-22" version="1">MLKKLISISLTLILLLSNVGFTYGTHFCMGMAVKSEVMLGQEHLDCGMGMMDVDKHSDGVHFSEPECCENQYVTAETDHQYTSDVSVTLADMMGTPAMAFVLYHVVVVPTAEQTFILDTSPPLPDQEIILLTQSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N3</accession>
    <name>A0A654E3N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="540" mass="59112" checksum="7E414046A8218116" modified="2020-04-22" version="1">MYHLILNIMRTIYFKRLMLLAMVLFSSLLISCGEDDGPKEPEVLLPNLDGLYVYGTSTVAAEPGGAASKINLAILDPGQGAQVESMDGVFGKFIHIGANSTISFAYVSGGEGVVYGADGGGSLDSANTVGGVINDKVIHGTLVQDADPINVTNAGLYYVFVNINTESFTLMEVKANMIGDATELQWSAGTALALKSSDNDKTVFEGTGLALTGATGYRYRFNDGWHVYSDETIVTLSSLGVPSYGDAWDSGINDLGFYLDNIPHKETGIFTVTLTYTASTGEWEEVKTKTGDLENDYSSLEIGWFGNAYLIDGAEPSEQWGTVHLVKTPTKDLKLYNWTWTIELIEDRSFVLRDPDGTVWITHGGAAKVGGAFDDGDIIKEEGQDNYFVVTPGIYEVTFTINSEDDGRTLTMERTTQFPDYSDKEYGIFGNAYYVEGTTEGAWEAIHHIKTPEKDGNKYNWTWTLELIEGRSFVFRENAENGEWVTYGGAAKIGEAFESELIIKEDGQDNYYVATGGNYDITFTINAEDEGRILNIVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T7</accession>
    <name>A0A654E3T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-5-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04629">
        <property type="entry name" value="CBS_pair_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044729">
        <property type="entry name" value="CBS_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="152" mass="17037" checksum="DA61DAEFBD02FA0B" modified="2020-04-22" version="1">MVKSYRGVQQAKPLPKAQKVSVADYMSTKLITFRPDQHMDEVIETLLKNKISGGPVVNEHGELVGIISEGDCMKEVVRGKYNNMPNLNGKVSEHMTTGVISISPETNIFDAAKMFLDKRIRRFPVVNMGKLMGQISQKDIMRAVHSMQSSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U1</accession>
    <name>A0A654E3U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21938" checksum="CCA8CC660A7C3936" modified="2020-04-22" version="1">MDQENKHLVNIPSSFYSFKEEGPFQHCVECDRFLLDESCDYVIEKAIRNYPDYKASDVIFDYAICMDCAMEIQKGLSAESMRKIQEFMQDHLHQNMTMREPAADPDSYTEHCLVSNRPVAECEEFQIFAYCRGNKVNLQMPPYMISGQVLDQISELLSPETRDELDGFFNKHFAPDPSLMEPTPRLVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V3</accession>
    <name>A0A654E3V3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispU</name>
        <name evidence="3" type="ORF">MARINOS108_20526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="27810" checksum="A9E4925BA1847353" modified="2020-04-22" version="1">MKEQINQGNLPQHIAVIMDGNGRWAKQQGAARIFGHKNAIKAVREATEGCAELGVSCLTLYAFSTENWSRPKQEVQGLMTLLVATINDEVPTLMKNNVSLHSIGDISQLPEKAQKKLQEAIDKTSKNDGLKLILALNYSGKWDLTHAMQALALEVEKGVLKAEAVDHKQIEKHLSTYGFPDPELLIRTSGEMRISNFLLWQMAYTELFFTPVLWPDFRKEHLHEAIVSYQKRERRFGKISEQVNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y4</accession>
    <name>A0A654E3Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative UDP-glucose/GDP-mannose dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.132</ecNumber>
            <ecNumber evidence="5">1.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.132" evidence="5"/>
    <dbReference type="EC" id="1.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047919">
        <property type="term" value="F:GDP-mannose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="313"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="46285" checksum="CC8442BF8631E8BF" modified="2020-04-22" version="1">MEFKIAVIGLGYVGLPLAVESGRKYKTIGFDINTTRISELKAGTDRTQEVDKEDLLGAKHLTFSSEPSALSDCNFYIVTVPTPVDQHKKPDLSPIISASRMISSLLKKGDIVVYESTVYPGCTEEICVPELEKSGLVFNEDFFCGYSPERINPGDKVHRLTTILKVTSGSNPEAAETVDHFYKSIVTAGTYKASSIKVAEAAKVIENSQRDINIAFVNELSLIFDRVGIDTQEVLEAAGTKWNFLKFTPGLVGGHCIGVDPFYLTYKAEELGYHPQVILSGRKINDNMGAYVAQRTIKLLSQKKKLSQQTKVLILGITFKENCPDIRNSRVIDIYRELVDFGVDTDVFDPNADQVEVSVEYGINMLNEPVYSSYEAIILAVAHGQFLELDWSSIRNNISVIFDVKGLLPKEFVDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E413</accession>
    <name>A0A654E413_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024949431" evidence="2">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="30"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="371" mass="40898" checksum="2869E8DC14F69C1A" modified="2020-04-22" version="1">MRKALIVGMLLFGASQNLSAQENLPVTDSLDLMIGQMILTGLGDFNKLDKRAPVFEAIRTGKVGGVILFEKNLNSINTEENIQEILSYAQAQTEIPLLVSIDEEGGRVNRLKTKYGFPRTVTAQYLGNLDHPDSTSFYARQTASILYQLGINMNFAPSVDVNVNPSNPVIGKIGRSYSQDPALVARHAQLVVEAHDLFGIATVLKHFPGHGSSRDDSHLGLADVSDTWRFEELLPYKALLDSGKVRAVMTAHIVNEVLDDRKLPATLSDKVISDVLRGFLEYEGVVISDDMQMRAISAQYGLEEAIKMAINAGVDILLFANNVPDYDLVTAEQIHAIIKKFVKNGDISEEQIAKSYKRIMILKAEMGLSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E452</accession>
    <name>A0A654E452_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD20003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="367" mass="41566" checksum="D8F5E8E8A0C17FE3" modified="2020-04-22" version="1">MRYFIVAGERSGDLHGANLIREITKQDPQAEIVGWGGDLMESAGARILKNYRDLTVMGFWEVIKTFWTLRSLLKECQRDIREFAPQVLVLIDFGGFNLRLATYARHFEIKTCYYIAPKLWAWRPQRISRIRRSVDQMLVILPFEKDFYQGLQYEVTYVGNPVMEALSAYEWNDTLLHVLKRHKSIAFLPGSREQEIKQAIPVVQKISTVFDDYQILVSGVSNVDKSIYEPLRNLGNISLVFDKAYELIQSAEAAVVTSGTATLEAALIGKPQVVVYKTSWLTYLIARRMIRVAHISLVNLIAGKEVVKELIQGDYNAVNVASELETLLSDVASKKRISEGYSEIRSILGETNASEKAARHIINLGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q4</accession>
    <name>A0A654E4Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="594" mass="70353" checksum="66EB92EC7ECDC4A1" modified="2020-04-22" version="1">MAKRELSILQKMYKEFFLALLAEYELDSPAKLSHFQKREFFTRIKEGWKVKTAALAKAKVRTTPLSKKFQYAKVKVSESLIALEPKAAYGQTLPSKTEEVTVKILSEENPEQTDDLKIKYHPNQFFEQDDLMYTYPVVKMPREESYLKLPRKRRAMGKGYKEADFYKAIIANIPEVEVDVDLHMAIPHYSRPYEPDIVLIDRELNLYIDIEIDEPYDGYYRFPTHEFIRDEKDVIVKKDNIRDLFFTESGWVVIRFTEYQVHLQEKQCIAYIKDVLNSIYTYRLDESSNCTLEPQWDYQQAVRWEKSHYREKYLGIEKFGKQKATSEIIVDFNENESIERSLNRTKRSKSEALQGNVAFEDETHTYHHPKDETGNAEYISVTTLIDRFFPFDIDRFIQGKVKKEGLSEEEVLEEFLRNRDEAAEKGTYLHEQIERFLKGESYDECTKEFAHFRRFYNHVIVDKGFQFVEAEKKVLLEEYNVAGTVDALFKKPDSNDYVIIDWKRSKKLVIDGYPRKFGYGYALSELGNLDNSSYNKYSLQQNIYKYILEKKYGFPISSMNLIVLHEKYDDYYRINLAEMGKEVRIILDSINHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E547</accession>
    <name>A0A654E547_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="34350" checksum="3A09984C3B5BA2AA" modified="2020-04-22" version="1">MKFGSVDNPALVDFTLPADHPGTERVLTSKGGAGLSEIYVGCAKWNKGDLKKFYPKGVKDELAYYAQQFNSVELNATFYNNYGPEQIEKWNEKVPDGFKFFPKVSRYISHIKRLNAVGVYVNDFCQNISTFGPHLGMAFLQVHDNFSPKNKDRISEFMDVWSWDIPLAVELRNTDWFNDEEASEWIYDLFEKYEVSNIVTDTAGRRDLLHMRLTSPVAFVRYVGANHESDYQRLDDWIARIKIWKAQGLEKLYFFVHQNLEKASPFLSAYFLEQFNKEFGTDLPLPELGEQAQGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E598</accession>
    <name>A0A654E598_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-processing RNAse BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="50531" checksum="3307C9A294FF7F98" modified="2020-04-22" version="1">MVARHVNSIKNFLHEDLWKIKLDTLPKRRRFLYRQIRIWVITLSEFDKDKCGEKASALTYFSVLSVVPVVAMAFGIATIFGLEDYLKNELIKYFSGQQEVLDYTLKFANKMLSTSSGGIISGISAVFLIYAVARLLNNIEVAFNDIWNTRKGRTLKRKLTDYMSVILLGPLILIMASSATVFITTSIESLTDSMGILGLFRPIILFFIKLIPYTLIWFLLFLLYMVFPNTSVKIKPALIAGVLAGTAYQITQFAWIEGQVYLSRYSVIYGSFAALPLFLIWLQLSWMILLFGAEFAFAVQNVGGWAYDNEELKMNLKSKRKMTLLVLRRIVKDFQSNDEPVSFEHLCSSLNIPRRFIREILDDLETARLIVKVADPEVEQFQPGMDIHKIDVFMVYDRLEKLGMDNLPQASDNEGFENIEILLSEVDKAIKEAQSNKKVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B3</accession>
    <name>A0A654E5B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32966" checksum="CFEF4B84B5D822D0" modified="2020-04-22" version="1">MSNLLNPDVSVIVPCYNGEDYISETIQSVLDQSYESLELIIVDDGSLDRTGDVVAQCSDARLRYFRTKNCGVSHARNFGIGMARGEFIAFLDADDLFMPENLSVKIGFLREHLDMDLVHAPEIIFDGNTGAHQRVSSGLGGTVLSELLLLDTTVIHSPSSVLVRRKLLAATGLFDERLSVSADWDMWVRMALVTPFGFLGSPYTKYRLHQNQMHSNIGQMEKDMSTSFDKLQTLGVWRNKKALRRSKAKLFLTLCLCYIKDDTRFLRSLHFLLRSLINTPSVLFVYLRKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5K6</accession>
    <name>A0A654E5K6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="316" mass="36033" checksum="DF253B706B69CA39" modified="2020-04-22" version="1">MKKILVIGACGQLGTELTLKLRDLFGIENVVASDLREAVDLIKDGPYEQLDVMDKSRLDEVISTHNIDQIYHLAAILSARGEQNPMLAWDLNMTSLLNVLETGRDRISKIYWPSSIAVFGPDTPMVQTPQTTVMNPNTVYGISKLAGERWCEYYFQKYKVDVRSMRYPGLIGYKAKPGGGTTDYAVDIFWKAILDNSYECFLKPDTLLPMMYMDDAVKATIDLMQADPTALKVRSSYNISAMSFSPDMIYREICKRYPDFQIEYNPDFRQQIADSWPDSIADDQAREDWNWSPSFDLAKMTETMLDNLEVQLVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5S6</accession>
    <name>A0A654E5S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="18854" checksum="3F84FA47232580A9" modified="2020-04-22" version="1">MAILTTPRLSIEKVTLNDSAFIFELMNTPTWIQYIGDRSIKSIADATAYIETNYLTSYKENGYGLYKMVLTSTLAPIGMCGFVKRDYLDAPDIGFAVLPAYEGMGYTSEAATKILDYGLHTLNLELVLGITSLENIRSQRLLEKLGLIKQGTIQSAEIGKTLYLYSTQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5T9</accession>
    <name>A0A654E5T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.125</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kduD</name>
        <name evidence="1" type="ORF">MARINOS108_90014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.125" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008678">
        <property type="term" value="F:2-deoxy-D-gluconate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="27215" checksum="078F59F4D4497CEB" modified="2020-04-22" version="1">MVLDSFSLAGKTALVTGCKRGIGKAIAEGLAEAGADIIGVSASLELSGSEVEKAIQARGRSFKAYQSDFSDRESVHAFLRKLMDENSEIDILVNNAGTIMRKPAAEHPDEYWDEVIEVNLNSQFVISREVGKHMIAKGKGKIIFIASLLTFQGGITVPGYAASKGAIGQLNMALSNEWASKGINVNAIAPGYIATDNTKALRSDADRSDSILSRIPQARWGDPEDFKGPAVFLASDASNYMNGSIVTVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Y3</accession>
    <name>A0A654E5Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008719">
        <property type="entry name" value="N2O_reductase_NosL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41247">
        <property type="entry name" value="PTHR41247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05573">
        <property type="entry name" value="NosL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024852560" evidence="1">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="468" mass="52261" checksum="2B7381EC1451B532" modified="2020-04-22" version="1">MIRSFFLLIYLMSTVVFAQSVNIDQDLCKHCGMLIRDRSFVALAVDADHRTQTFDAIECLVNYLKVHDEASFSQLLVTDYSRSNGWIEAKDAFYIKSSAIPSPMGAYLSAYSNLQEVQNIQTQMGGDIFTWTELLRQFEGSRFGVINHPDHHDRGDAYGPIGVMGDHVHHQGGWMVSVRSMFMQMSGNQTGTKSVSNEEVYTQYHAAPQQMRMSMYMLGVMYAPTDRLTLAMMQPLIWREMDMNAMNHQAMPMSEMSYQTRSFGLGDLKLSALYSLIAKTGSSFHLNIGISLPTGSYDQSDNTPMSDNMKLPYAMQIGSGTTDLNLGATYKVAFEKVGLGVQPMALLRIGENRSSYRLGNQYGLNSWFVYTPDNWLGLVGRTELILRHKISGIDSDLNPMMAPPSNVENSGSEQVNVFAGVNVGFPASVTSLKNVKLGMELGTPIYRSVRGIQMTESFTINSGIRYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6H2</accession>
    <name>A0A654E6H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023856">
        <property type="entry name" value="Bacillithiol_biosynth_YpdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04018">
        <property type="entry name" value="Bthiol_YpdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="36752" checksum="3EA079BB6A056525" modified="2020-04-22" version="1">MSENTDVLIIGAGPIGLACGIAAQDAGLSHTIIDKGCLVNSIYNYPHNMTFFSTSDRLEIGRVPFISHNPKPTRPEALEYYRRVATSRQLNTRLYENVLEVKKDKEIFHVNTSKQSYSARAIIIATGFYDLPYLLNIPGEDLPKVKHYYDEPHPYFDMRVAVVGAANSSVDVALETFRKGAKEVVMVVREKEINPRVKYWVRPDIENRINEGSIKAYFESQITRIEEKSIDVQTPEGDITLPNDFVLAMTGYQPDFTFLKKVGINIGTDEYMTPEYDEHTMETNVENVYLAGVICGGLKTNAWFIENSRVHADMIVNDLRTKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6L1</accession>
    <name>A0A654E6L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22782" checksum="6095465570BF804C" modified="2020-04-22" version="1">MANSVFDTIYQLQNVESKIIVSLERISEAFKVLLWEDSKTHGLTPIQVQILVFCLFHSPDKRKGKRLASELNVTKATISDAVKALEQKGLISKTTETDARSYIIDLTTHGKEVAEKVSFFANPLHSPIERLSEEKKSILLRSLLDLISNLQSAGIISINRMCLSCKYYEPRQEDHYCHLLQKKLSDQELRIDCSEHVSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6S6</accession>
    <name>A0A654E6S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="20234" checksum="2E9542C997083D2B" modified="2020-04-22" version="1">MKTLLLFFQLMSPVADTVQQGGDYPSYLSLQNCVILDLGPSVQSENKNLIYSWDFGDGQRKLGIVSEHCYDEIGDYEAILSVTDPYSGTHFRDEYYVDVEIRPSVELDIVEESAQMLSAELRAASEIEAARFYWDIDGQYYMGDQIEGDFIKGAIQIRLLAIFTYRGEVVQLSKTVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6Z7</accession>
    <name>A0A654E6Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxaloacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="529"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="616" mass="68084" checksum="8256BF93BC2182F2" modified="2020-04-22" version="1">MAKEIGLGLVYRDMWQSSGKYVPRVDQLVRVAEPIVEIGCFRRVETNGGGFEQINLLYGENPNKSVRDWTQPFNDAGIQTHMLERGLNGLRMYPVPRDVRRLMFKLKKLQGTDISRSFDGLNDTRNLKLSIDYAKEGGMIAQTALCITHSKLHTVDYYIKMAEELMEMGAEEICIKDMAGIGRPASMGKLVAGIKALNKDIPVTYHGHSGPGFSVASSLEAARAGADFIDVGMEPLSFGTGHADLLTVHEVLRDAGFSLPDINMKAYMQARSLTQEFIDDFLGYYINPKNRHMNALLIGPGLPGGMMGSLMSDLENNLKGLNKWKEKNNQAPLSQDDLLIKLFEEVEEIWPKMGYPPLVTPYSQYVKNAALVNVMQMEKGKDRWSLLDDNTWDMLLGKSGRVPGELAPELKKLAKAQERSFFEGDPQDLQPDALEDFRKKMKEQGWDTGQDDEELFEYAMHPQQYEAYKSGKAKSDFETDLARRKTDSATSTGASAVAKPTALDVEVDGQKFRVSISYSAADGAPEKATASAGSPASNGASHEIIAPLEGKIFMTKSAGEKPLKVGDPVKKGDVVCYIEAMKVTNAVKSDTDGVVQEILVHEGDEVYDDDVLIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7M9</accession>
    <name>A0A654E7M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="138"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="779" mass="87411" checksum="E4A58BA12D3B4135" modified="2020-04-22" version="1">MTKKILSLVSLNLLGGLLFGQNFTINGYIRDQVTGENLIGATILDPATMQGTITNTFGFYSLTLPTGTYQLRCSYVGYQSWEQEVTLTQNQNLNISLAPGTTLEEVIITAEENIELSPQMSSIDVPIEQIKALPVLMGEADLLKSLQLLPGIQGGTEGSSGIYVRGGGPDQNLILLDGVPVYNVSHLFGFFSVFNPDAINRVNVVKGGFPARYGGRLSSVIDISMKEGNNQKFSGEGSIGLISSKLTLEGPIGKDKKTSFLVSGRRTYIDLLTRPIIRAQSDGQASGGYYFYDVNAKMNRIISDKDRVYLSFYNGLDKGFGKDAYQYQSDGVKYTDKNKFGLNWGNTITALRWNHTFGPRLFANFTGTYSKYKFRIFSEYETITKDGNQTEREAESIEYFSGIDDLGFKVDFDFLPSPQHNIKAGINMIHHQFNPGILGYETNLEGESDTTLGANKTLAAEFATYVEDDFKISDKLRANGGLHYSSFLVNQKYYHSLQPRLSMRYLLGNDLSLKASFATMTQYIHLLTNGGLGLPTDLWVPATDRISPQRSWQVALGAAKTFSGFEGSIEVYYKEMNNLIEYKEGASYFNLGSDWQDKVTVGSGESYGAEFLIQKKTGKLSGWVGYTLSWTNRTFEALNFGKQYPYKYDRRHDVSIVAVYNVSKTFAISSTWVYGTGAALTLPESEYEQENSNGYGGTIQKYSSRNGYRMRDYHRMDLGLTWTKPKKNGDRSWSLGAYNLYNRKNPFFLQQGYDNRGNKKFIQYSLFPLIPYVRYSFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E896</accession>
    <name>A0A654E896_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="27352" checksum="9E24A356774EAEE5" modified="2020-04-22" version="1">MFGWFSKKVGIDIRVDIHSHLLPNLDDGVRDFDESLEIIRGFSRLGFKKLITTPHIYSDHYPNNRETILGALDQLKELLRQERLSIEVEAAAEYYIDSHLIDLLDGKAPILSFGTPRYVLVETGFHTKPIIFDEVIFKLKSLNYVPVLAHPERYMYLEDDLSWLRQIREKGVRLQVSIPSLNGFYGSNPKRMAMKLLKEGMVDFFGSDLHRKSQMEGFEKSLGIKISPQNVLNNELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8D5</accession>
    <name>A0A654E8D5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="9" type="ORF">MARINOS108_20928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9566" checksum="93844D595015B05B" modified="2020-04-22" version="1">MANHKSALKRIRSNEAKRLRNRYQHKTTRTFIKRLREATDKTEAQKLLGEVLGMVDKLAKNNIIHNNKAANLKSSLTKRVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8K6</accession>
    <name>A0A654E8K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021428">
        <property type="entry name" value="DUF3078"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11276">
        <property type="entry name" value="DUF3078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025035000" evidence="1">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="33504" checksum="6CEDFB1E39E24C36" modified="2020-04-22" version="1">MNFKILLSAGMILCSSLLFGQVKDTTYWVSGGFVAATFSQVSLSDSWSAGGTENVAINGATGLFADYKKARSTWENSLDLGYGMINQNNQGFQKSDDKINFVTKYGYRIKEGNANWFFSGLLDFRTQFDEGFTQTEDGRDSLISKFMAPGYLTMGLGIDYKPNPKLSFNYIPLTGKFTFVNDQTLADKGAYGVDPGSKSRAELGSFLRIKYKDEVLKNVNVETRLELFSNYIKDFGTIDVNWQTTVVMKVNKVLSANLFTHLIYDKDIKTQTDEGEEARVQFKSVFGVGLAYNFGAQRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E939</accession>
    <name>A0A654E939_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024984970" evidence="4">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="5">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22721" checksum="9E7EE28C3CD1DC3D" modified="2020-04-22" version="1">MKNIIILLIVLFQISCTSAQDKQVGGRCEGCEALYEYGSRLLNSVDTIPGFEQSAAKMKVTGVIYHNDGVTPAKDVILYIYQTDERGIYRASTDAQGWERRHGQHRGWIKTGSDGKYTFYTFRPASYPNTTIPQHIHATVKPPGYTDYFIDDFYFDDDPNLTPTLRAQDKRRAGSGIVALKMENGMLLAQRDIILGLNIPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9H8</accession>
    <name>A0A654E9H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="PTHR46044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="18313" checksum="5EC427476C1F38F5" modified="2020-04-22" version="1">MSQSDLLKIAIAQIAPEWLHREATLQKVVHCVKEAAGSGAGLVVFGEALVPGYPFWVEKTDGAVFESAIQQEIFAHYMNEAVCIERGDLDGLCAIASEYEVAIYLGIIEQPRDRGRSLYCTLVYIDQQGIIQSAHRKVMPTYEERLVWAMGDGNGLVTHSLAPFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9L3</accession>
    <name>A0A654E9L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">secF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="11" type="ORF">MARINOS108_60124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="850"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD20973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="996" mass="107922" checksum="91A547238A0DD64B" modified="2020-04-22" version="1">MKNKGFVVSLTIVISLLCIYYLSFTFVAQKIQKEATEATTDASGNINFAEKQRYLDSIWNEPVYNLLGLDYTYQDIKETELNLGLDLQGGMHVTLEVSPVDILKGLSGNNQDPDFQSALITAKANIRGTQNNYVDEFYRVFKASAPDKSLAFIFSNTANRGRISLNSTDDEVLDIIQAEVESAIDRSFNILRTRIDRFGTSQPNIQRLQGTGRIQIELPGVDNPERVRKLLQGVAKLEFWEVHEINEISPTLQAINDLLVKEQKATLNPEDLTASTETVQEDLSLLTEDDNASDTADTTALAEGDSAASNLDSALNSQVSPLFSLIKSQYGLVYDVKDTSTINRILQREDVKSVIPSNVKFLWSVKAIKSEAVGSPELLELHAIRTSRTGKAPLTGEVITDARQDLDQRSRPAVSMQMSAAGAKTWRRLTASNVGRRIAIVLDNYVYSAPNVEGEIPNGNSSISGSFTIEEAKDLANILKAGALPAPTTIVEDVVIGPTLGKVAQEQGIISIVAGLGIVIIFMVFYYAKGGLIANVALFFNIFFIMGILAQLSASLTLPGIAGIVLTIGMSIDANVLIFERIKEELRNGSGLKAAISTGYSKAYSSIIDANVTTFITAMILYILGQGPVKGFAITLMIGIACSFFSAVFITRVIVEAFSKKGDNSKLSFANAFSRNALVGLNIDFLSKRKMAYIFSSTFIAVGIVAIFIKGLTLGVDFKGGRSYVVTFTEAAVPSALKASVAPYFDNQGTEVKTYGANNIMKITTSYLIDDETDAADLKVKNALIEGITASGLTYSTNADLGPDSFTISSSSKVGATIADDIKNSSYESALFALIAIFLYILIRFRKWQFGLGAIVALFHDTLFVLSAFAIVSLFGITYEVDQVFVAAILTIIGYSINDTVVVFDRIRENLGIKTGSEMKKVFNESLNSTISRTLITSITTLIVVLVLFIFGGAALKGFSFALLIGILIGTYSSIFIATPVVIDLNTKKDAKAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAD2</accession>
    <name>A0A654EAD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-binding glutamate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_synthase" evidence="4">
        <location>
            <begin position="153"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="504" mass="55983" checksum="C85236A352F0B7A8" modified="2020-04-22" version="1">MRHTFYFLTPLILIAVGLVGYYYSSDWLWSYTVLIPLAFIGFYNRVQRSHTILRNFPLLGYFRYFFEMISPEIQQYFIERSTDGKPYSRNHRALVYRRAKNVNDTHPFGTQMDINNDHYEALRHSIYATPPVKEFPRVTIGSSKCGQPYSASILNISAMSFGALSKNAVRALNGGAKKGGFYHNTGEGGVSDYHLAEGGDLVWQIGTGYFGCRTPEGDFSPELFAEKAANPVVKMIELKISQGAKPGHGGVLPAIKNNEEIARIRGVEPHTMIISPPGHKNIRGPEDLLYFIQNLRELSKGKPVGFKLCVGRTEEFIALVQKMKALEIWPDFITVDGAEGGTGAAPLEFSDSVGLPLEPALIFVHSTLLKYGLRDEVKVIASGKVLTAFSILRMKALGADICNSARAFMFSLGCIQALRCNTNDCPTGVATQNAMLTKGLVVTDKIDRVYYFHHNTIHAVLELLGACGLSHTEEITIDMFVKGDEMVALTNRYFPDSVLNRVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBP0</accession>
    <name>A0A654EBP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">serS</name>
        <name evidence="11" type="ORF">MARINOS108_20127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="179"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="427" mass="47827" checksum="459CA69EEEB41418" modified="2020-04-22" version="1">MLQVTAVKENFENFVNGLKKRGIQNAEEQLNELIQLDDERKKTQQSLDDILANSNLLAKKIGQLYKEGKKEEADAAKAETGQLKEESKQLSEVLSAIENQLLDKLYSIPNIPNPLVPAGKSEADNEVVKLDDKNLPALYDGAKPHWDLITEYDIIDFDLGNKVTGAGFPFYKREGARMVRSLVNYFLDEAQQAGYMEVQPPILINEESGYGTGQLPDKEGQMYGITGTNLYLIPTAEVPITNIYRDVILDAGSLPVKNVGYTPCFRREAGSWGAHVRGLNRLHQFDKVEIVQIAHPDQSYEILDGMVAHVEHLVKSLGLPYRILRLCGGDLGFTSAITYDFEVYSAAQEKWLEVSSVSNFETYQANRLKLRFKDKDGKKVLAHTLNGSALAVPRILAALLENNQTEEGIRIPEVLRQYTGFDIIKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBR0</accession>
    <name>A0A654EBR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone NosL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008719">
        <property type="entry name" value="N2O_reductase_NosL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41247">
        <property type="entry name" value="PTHR41247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05573">
        <property type="entry name" value="NosL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="355" mass="39596" checksum="53E7D35AAA5D9B86" modified="2020-04-22" version="1">MKKASILMIIGSVMLLGLFVFPMWNIRLGAPQYPEPLGIDIYVNGLQGESEFDIQNIDGLNHYIGMKTLPKPEEMWEFSVFPKVVMAMASLGVLIGLLGFLGKIRPIWFLIWFLTMSALGALGIYDFNLWLVAYGTDLDPNAILKLVNPDGTPMQYNPPLIGHKKLLNFDAFSYPRLGGILLGIGMTLAAVAYFVGKKSKSKRYLAALKNSALVVLIFLVSQLLSSCQPGPEPIHYGQDACDFCRMTIVDKQHAAQMVTEKGRVYKYDAIECMLNDLKDWDRPAIQYHLVADYQNPGKLTDAIKASYLISDKIPSPMGAYLSAFSTTQSRDKTHHSVGGQTLEWTQLQNQFEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFN2</accession>
    <name>A0A654EFN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7583" checksum="8BA114CEE7D89AAA" modified="2020-04-22" version="1">MRISQLRSFYVLDLIAMNIQLLWSQYLNGRTEGILLNIRLTKNHERHQRCQMSIATFHIKEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSM7</accession>
    <name>A0A654DSM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="41571" checksum="A4AB803B95AB1FEB" modified="2020-04-22" version="1">MKKSLISLAAGGFGIGMTEFVIMGILPEIATSMDITIPEAGHFISAYAIGVVVGAPLLTALGSKWPAHKMLIGLMVWFTVFNSLSGFANSYWSLMLFRFLSALPHGAFFGIGAVVASRLARPGKEAQAIAAMFSGLTLANIIGVPFGTYLGQEFHWSMAFFVVGIVGIITITSLRFWMPALAQSSEQSMSEDFQILKKAELWMVVLLTTIGTGGFFAWYSYIAPLITEVAGHDPGMVSYAMILAGCGMFAGNIAGAKLAEKMQPIYAVVLALGVMTLLLLANVYLAHDPVAVLVMTFIIGFGAFCVAAPIQMAMINTARGSEMLGSSLNQSAFNMGNASGAYLAGLPIAMGYGFTSADVVGALMAFAGVFLALGIIQMRKASRRKMAAAVEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT38</accession>
    <name>A0A654DT38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkane 1-monooxygenase 1</fullName>
            <ecNumber evidence="10">1.14.15.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alkB</name>
        <name evidence="10" type="ORF">MARINOS108_10246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.3" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018685">
        <property type="term" value="F:alkane 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052869">
        <property type="term" value="F:arachidonic acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="106"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="40421" checksum="722C630393DFE2A1" modified="2020-04-22" version="1">MNLGALKYLSVLSLPVLAYFSFHSTGWLTFLPLLEAFMIIPILELFFKPDPDNFSEVEEQKRLENPIYDLLVYLVVPIQLVCVWWFLESMTQPVELLTRIGRITAMGMLCGVMGINVAHELGHRKRKYEQQMSKLLLLTSLYMHFFIEHNRGHHKHVSTAEDPSSARLGESLYAFWIRSVVLSYLSAWKLEAGRLRKKGQHTFSIHNEMLQFQVIQLTFLLVVGYVYGWAVMLYYVLAAIMGFLLLETVNYIEHYGLSRNKTERGYERVMPAHSWNSDHLVGRIMLFELSRHSDHHYIASRKYQVLRHMDESPQMPTGYPGMMLMATVPPLWFYVMDSRIGEYRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTT1</accession>
    <name>A0A654DTT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized acyl-CoA thioester hydrolase YkhA</fullName>
            <ecNumber evidence="5">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ykhA</name>
        <name evidence="5" type="ORF">MARINOS108_10056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="19448" checksum="7C98C383228FB2ED" modified="2020-04-22" version="1">MSKKKKHCRESFVTMTEMVLPNDTNTLNNLMGGRLMHWMDIVSAIAAQRHSNRIVVTASVDNISFSKAIQLGNVVTLNAFVTRAFNSSMEVYIEVTAEDVPSGRKIETNKAFFTFVAVDQMGKPIDVPEIEPETADEQELYEGALRRRQLRLVLGKRMKPEDANELKSIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU89</accession>
    <name>A0A654DU89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="48355" checksum="5D2ECA4C374AE13E" modified="2020-04-22" version="1">MPEPIQERRLSLLQATAINMIDMVGIGPFITLPMVISLMNGPYFLYAWMAGAALSFIDAMVWSELGAAYPRAGGSYNFLKETFGKSKSGGLMSFLFVWQTMIQAPLVIASAAIGFASYFSYLLPLGPVGSKVVSGGLVICIVIMLFRRIEVIGRISVVLWVAVLGTILWIIGGGVAHGNFLQPLIDINKDLNFNYAFVASIGFASVKSVYSYLGYYNVCHLGGEIVNPTKNIPKSMFLSIGGIFVLYMLMNVSVVSVIPWQIAKESEFVISLFMEQLMGPMAGKIVTVLILLVAFSSVFSATLGYSRIPYAAAVDGAFFKPFAKLHPKGNFPYVSVLFLGGIAFVFSLIFKLSEVISAILAMRILVQFIGQAVGLLMLRQKRKDFPFKMPFYPWPVYIAIAMWCVILASTGYQMVLGGLLFALLGVAAYYIKQRISTAGGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUD5</accession>
    <name>A0A654DUD5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="2">
        <location>
            <begin position="181"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="321" mass="36964" checksum="F3644BF36CE5C755" modified="2020-04-22" version="1">MNPTLFMDFTVDKSNNTMHIKRQFDAPRDVVWKAWTTAEILDQWWAPKPYKCNTKTMDFREGGYWLYYMEGPKGDIHWCRADYSSVNPQESYEATDAFCDSDGKINNIHPGSHWHNVFADFEGDSTLVTITITYKSLEDLEKIVEMGFKEGLAMGMENLDYYISTQFKLRKENKVTNKAGVATYLNFPGNTEEVFRFYQKVFGGEFTGRGLQRFEDFSFPGQPPMDEATKKLIIHVELTILGGHRLMATDAPESMGFKVNAGNNMHIHLEPDSKEEADRLFNELSAGGEVEMGMKDMFWGAYFGSFQDKYGINWMINYQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUD6</accession>
    <name>A0A654DUD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="351" mass="39524" checksum="316A1580765B19E5" modified="2020-04-22" version="1">MRMYPKLKFELMALLLLCTYYGYSGVLEEKKQVIEKSYDVTEKTAFEATNQFGDVHVNTWDQKKLKVVVEITANGKSEERAQKMLDRISIQIVTKGSLISFVTAMDGNMNAKGDESFRIDYTVNLPAGNKVAVTNKFGDIYLGNRTGDVDLDLSYGNLKAEDIQGYLELELSFGKGFLGNTGKSHIEVKYSELDMGNATSIEMEQQFSDVEIGDVDELEIESKYGAVTLGTVGVVDSDVQFSGFKIERLLKSLYMEANYVSEFEIKSLSKDFTKVSFFGKFSTINIRLEEGLKADLEAEFSFSNMNSSISNMETYYRVKEDHRSEYKARIGGGDPNKKIIVKSSYGDLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUD7</accession>
    <name>A0A654DUD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate or tyrosine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="471" mass="51827" checksum="2E36BF1145BFB296" modified="2020-04-22" version="1">MNTILKEDLLTLNKLLSDTLLQGLTYLSNLDQTPTSVSFDPPAERTLSTSGVGGEGALYEFINRFESLMVASSGPRYWGFVTGGSTPAALMGDLLATIYDQNTQTTKGHGDVSAIVEFETIRLLLELFDLPDDFMGGFVTGATMSNFTCLGAARQWVGGKQGYDIAKSGISRPIHILSAVPHSSSIKALSMLGIGSSQVTRIPTINPTREAIDISKLEEAIHQLDGEPFILISSGGTVNTVDFDDMKAISALREKHDFWWHIDAAFGGFAAVSPKHKHLIEGWERADSITIDGHKWLNVPYESAFFFTRKEHTLHQVDTFQNSNAPYLGDPNENFNYLNFLPENSRRFKALAAWFSLVAYGKEGYREIVERTIDMAQELGQFIADSEAFELLAPTRLNTVCFTLKNGSEADVNTFLSKLNDGGKVFMTPTSFNGRAGIRAALVNWRTTAADVQIVKEEMNQVIQGIQSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUF7</accession>
    <name>A0A654DUF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="22626" checksum="CD211092709D6F6F" modified="2020-04-22" version="1">MSIVRKVRAVERLFGRLDEEISQFRGATGVHCISGCGKCCTKPDIEASPLEFLPLAFHLFLTGKAEATLEQITLEQSSICLIYSPLSVIDNTKGSCGNYAYRGLICRLFGYGSSRDKFGELKMVTCKLIKEQQVESYEKAVAMLTRHEYVPVFSDYYKKLMQIDFQLGNQILPINEAIKAAIETVLHHYAYRPFPRIKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR9</accession>
    <name>A0A654DUR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22221" checksum="26DBECFF17762571" modified="2020-04-22" version="1">MKTVLIYLYKTLFVVFIFVLITNLAFLKQDDLIFDNIDVPGKDLIQFAIVGDAPYDTLGSTALLERFQSHIDDNNKRSYADFLIHVGDIKKGSTPCELSYYTNTLKVLESSSKKPYLLIGDNEWNDCDHGTDPTIGLEHWESTFTDLNERFINDFDANSQPGRPENIAFLRNSVLFLTINQVDGRIHDSTECQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT0</accession>
    <name>A0A654DUT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterol desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="47695" checksum="F6ECEEC33229BA2B" modified="2020-04-22" version="1">MNIDPIILSIPIYFLLIVAELLIQFFNKQKIYRLNDAVTNISCGITQQITGAFFKVTTIAAYQFVYENWSLFRIENTWWSVTLLILAVDLCYYWAHRMSHEVNLFWGGHVVHHQSEDYNFSVALRQGSFQILWTFWFYIPLAFLGFNTVTFLIVLALNTVYQFWIHTETIGKLPRPIEFIFNTPSHHRVHHGRNPKYIDKNHAGSLIIWDRMFGTFQEEEERPTYGITKPINTWNPVWANLQHYVDMTSQLRSTPGLMNKLGVMFYKPGWRPVAQGGYQSAPEVDKVNYRKYDTHPAFKMSLYVLVQFIITLAVTSAFLFTLADQELINKLTFSLVIVWSVAQFGLLLDNHPEWSRLEYLRILFCGGVFAFLYPYPLIIIPSIIYIGVALISFFFIYKPATDTVGSVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV73</accession>
    <name>A0A654DV73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="57" mass="5995" checksum="DDC6A642EDEA45F2" modified="2020-04-22" version="1">MNSSLLSVRERTSFPGGGNHIAVLFSEGKASLMNLSDGSTELTMTGSDSSCRLEMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVH6</accession>
    <name>A0A654DVH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024841444" evidence="1">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="41764" checksum="F8738BAAD7523963" modified="2020-04-22" version="1">MKRHILSILIIILVSFTALAQTRTITGSGDWSDITNWNGLLVGGAIDDNDDVVMNDNIDITIKNGESYTIASLDVSKDGSLTIEVGGILIVTGTVNVDKDFTINVLGDFTIENDLIVAKDLVMNVGTDSNFNVGGDVTLDKDATLDILGEMSVAGSLSSAKDATINVGSSGVLGVAEELNLGAGSVITGAGPVIAGSCTGAACEDGQLNQPVLPITLGAFELEVQNTSILLTWTTLSELNFEYFEIQRADASGTFETIDEVNGHGDSKVAIDYHWVDENPQIGINYYRLVSKDYDGYTEVFPASQTIFEHAYQDLSIYPNPARAGEQINISGISTELVNVKLYSSTGNMIKEISTNAGSFETPTDVKSGIYLVNLEVNGLQKRMRLIIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ9</accession>
    <name>A0A654DVQ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5011 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025060083" description="DUF5011 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5011" evidence="2">
        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="242" mass="25981" checksum="0E35BC44058A3759" modified="2020-04-22" version="1">MNYIFQSRIWVLLLLSVGFLACEPDLDSEDVTAGVIRFPSIILNGDNPIAYVAGEASAITDPGVTALLGTDDITSQVEVTGVDGVDFDTPGIYPINYSVSTVNDLGDETTVTETRYVLIASEDISGIDLTGDYFSISRSFSGASYGQLMSVRKLGTGYFACTDVYAHPAAENAGRFFVTSATEGILLPQSASETIFGLEMFGTVDIQIGNTNPDDYNLSFNLDLPAASFQTTKPWTKNENVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR8</accession>
    <name>A0A654DVR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative S-C lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaeR</name>
        <name evidence="2" type="ORF">MARINOS108_11149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08352">
        <property type="entry name" value="VOC_Bs_YwkD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037478">
        <property type="entry name" value="YwkD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="15122" checksum="3F980F605F8A3912" modified="2020-04-22" version="1">MAGLKSVHHIAIICSDYQRSKHFYTEVLGLEIIREVYREARKSYKLDLALNGHYVIELFSFPEPPARVSRPEAVGLRHVAFEVEDITEMVEALKAKGVETEPIRIDESTGRRFTFFEDPDRLPIELYEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW99</accession>
    <name>A0A654DW99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="11620" checksum="D3965AEF8C7D6C83" modified="2020-04-22" version="1">MAINVIAMKNCVFQLAERLVTDVTYQIVYLTLTKLRGNKGLKRLSYKAIWIMAKEFPHLMVGVVNFTFIIYDDRGTGKRFQHGKVMMADTFDIVHSSFSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD5</accession>
    <name>A0A654DWD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_11392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005898">
        <property type="entry name" value="Cyc_pep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43553:SF11">
        <property type="entry name" value="PTHR43553:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01194">
        <property type="entry name" value="cyc_pep_trnsptr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="330"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="552" mass="63199" checksum="3444DF6A4C2232A5" modified="2020-04-22" version="1">MKVIALLFKSSAWKFTVAAIASFISGTALTAVIYMINEAIKTEMANSDTIIWQFLGILLIYVTTSIFGAYLITLLSQVVIQDMRLTISNKILKASFHKLEYQTKRLFTILTDDINTISSIIIKLPAIFTAVTTVMACFAYMIFISWKLFCLFMIVFLMAFILYRLPLNSYGERLRKTRNHQNVLFGYFEGLIYGLKELTINKKFRSLYTKEIIEPLTEEQKKHQVIGKTTVEIFSRWGEVILFLGIGGILLIIKETGITTYDVMVQFLTVTVFTIAPLSKITRVLPDFQRINIALEQIDSAGLDLEKETAPALEEDNTKIFPVVESEPVISLKNVAYSYYHTEEEKFFKLGPINLDVKKGQVTFLIGGNGSGKSTLAKVLCGLYPPQEGEVTHFGKKVLPENVENFRDQFNVIFADFYLFDEIIHIPQSVIDEKAQEYLKLLELDKKVEIVNRKLTTTNLSTGQRKRLALLISYLEDKPIYLFDEWAAGLDPYYKKIFYKKLIPDLKARGKTVFAITHDESYFDCADEVIMLKEGQLLETHLLHDQLQEFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWH1</accession>
    <name>A0A654DWH1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_63" evidence="2">
        <location>
            <begin position="695"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="874" mass="102642" checksum="D2DA9F6D23E0BC31" modified="2020-04-22" version="1">MTQEEKRLEECRKGISWKEWGPYLSERQWATVREDYTESGNAWESIVHDQARSKSYRWGEDGLGGFSNSDQRICFAWAFWNGKDKILKERLFGLTGHEGNHGEDVKELYFYLDSTPTHSYMKMLYKYPINEFPYSDLVVENLKRTKKQREYEILDTGVFDKDEYFDIFLEYAKGAPDDFLLRAEVHNRSNKDAELTLLPTFWFRNTWSSGRDSNIPEISEVSPTEMLIKHHLLGDYHVYFGEEVKEQMYCDNATNRVRLYGVPNKQSNYPKDAINDYIINGKKTLNPKKKGTKSSAHYKVMVPAGGSKTVEIRMSSVALSLPFGDYQELLNKRKAEADSFYRSIQSKVIDKDLKNIQRQAFAGMMWSKQFYYYNIKNWIHGDPGRMKPSPSRKNGRNSDWQHVYNYDILSMPDKWEYPWFAAWDLAFHCIPITRIDPDFAKNQLLLLLKDRYLHPNGQIPAYEWNFSDVNPPVHAWAVLRVFQIDRETTGKPDFDFLQRAFHKLSINFTWWVNRKDKEGNNVFEGGFLGLDNIGVFDRNHPVVEDARLEQADSTSWMAMFSLNMLRISLDLSMEYPVYQDMAVKFFEHFLYIAGAMNSIGDTDVDLWDDEDNFYYDVMHTPDQPNQRMKVRSMVGLIPLFAIEILRTEVYSRLPEFRERLDFFLKERPKLASLVARWEEPGEGEHRLLSILRGFRMKRIIERMSDEEEFLSKYGIRALSKFHLKNPYQLEIDGQKLEVAYLPGESDSSFFGGNSNWRGPIWFPVNYLILESLLKYSHYYGKDYLVEFPIGSGVKHTLLEVTREICLRLMKIFMKDENGERPVYAGNKKFQTDPHFKDYILFYEYFNGDTGEGLGASHQTGWTGLVAELIHRYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL6</accession>
    <name>A0A654DWL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux RND transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="85"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="42065" checksum="889705E2DDEB4813" modified="2020-04-22" version="1">MRKINQITYIVIISALVYACGGTEAAKDKVTELNELKAQQKELETKISDLEAELIQSGQLEKKEGNKVLITTLKMTPDSFEHWVEVRGTVASRKNVMLSAETMGRIESIKVTEGQKVAKGQLLVQLDADILRNSISEVKTQLELAATIYERQAKLWEQNIGTEVQYLQAKNNKEALESKLKTLNSQLSQSNVVAPFNGIIDNIPVREGEMTSPGMPLVRIVNQNDTYISADVSESFLGKFQVGQQVKVYFPSLDKEVISKIASVGQVIKSENRTFEVEVGLPAVDFPIKPNQVVVLHMIDYKTDKALVVPTKLVQRDSKGSYVYELVDKEGKLVASKVYVKPGVSYNLETEIVEGLSAGQLIAYEGYRELAPGAAVTIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP5</accession>
    <name>A0A654DWP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="25462" checksum="6C3723CF05A31DD8" modified="2020-04-22" version="1">MKSYEININSNWRAIPVAIFFFGLSIYLMTLIPRDWPDLVNFGTIAILFFSPIIPVTILSRGKIRIELTEETFRAIWVKRFFLSNEQNIELGWNRIIDYVNQEDRGLDSFRLTLTNNQQFKFYRYTYFPQKDDFDKFLSQLPGFIKSVNLADERTIEQGKTEFQTRSFKWVLIGLTVLAIGLLVNTVMNPNSGTRWATLGVIFSGILFYWIQANRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ0</accession>
    <name>A0A654DWQ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22371" checksum="CE9D076D3F4401E8" modified="2020-04-22" version="1">MARTKQYFIIYKPFKVLTQFTSEDGNPGLGTIFDLPRDIYPVGRLDLDSEGLLILTNDKRLNSALLNPKNSHQRTYWVEVEGIPTETSLDALRNGLEINVKGIYHTLPCEARLIETPALAERDPPVNYIKHPVRSWMEIRLVEGKNRQVRKMTAKIGHPTLRLVRVGIEDLSVFPLQPGGITQISEKVLYKKLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS3</accession>
    <name>A0A654DWS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032577">
        <property type="entry name" value="DUF4920"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16267">
        <property type="entry name" value="DUF4920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="18091" checksum="CD289893A9C84BD0" modified="2020-04-22" version="1">MLVNIKKDISRLLSTNWVVLIISGTFLVVGGSSCENKKASWDSFGDPIAPEAAITTDAMLTGVASADSLAVKFEAEITEVCQMKGCWMTLKSADGSPVRVTFKDYGFFVPKDAAGKKVIIEGVALSEVLDEATARHYAEDSGKPFDENADLRQVSVIASGVLIAKEDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV0</accession>
    <name>A0A654DWV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">accA</name>
        <name evidence="12" type="ORF">MARINOS108_10857</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="35186" checksum="730BB94E20F1212A" modified="2020-04-22" version="1">MHLEFEKPIVELESKLADMKLLAQQSDVDVSAAITKLEEKIVKLKEDTFENLTRWQKVQLSRHPERPYTLDYIYEISDDFIELHGDRTVKDDKAMVGGFAKVDGLSVMIIGQQKGRNTKQRQERNFGMANPEGYRKALRLMKLAEKFNTPVITLIDTPGAFPGIEAEERGQGEAIARNLKEMMTLTVPIVSVVIGEGASGGALGIAIADKVLMMENTWYSVISPESCSSILWRSWDYKEQAAEALKLTAKDMLQHKLIDGIIKEPLGGAHTDMKAASKELKKEVVKHIKSLEKLSVEKRIAERIDKFSNMGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ3</accession>
    <name>A0A654DWZ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="23346" checksum="94D797796973D3F7" modified="2020-04-22" version="1">MNSTKAVFERFVPENSVTYCCKLLDYFGFEFKIKKSRQTKLGDYRYTPKTKKHTITINNDLNQFSFLVTFLHEVAHLVTFNAHGRKAAPHGQEWKDNFKKIATPVLNESVFPAPVLLALTNYFKNPKAASCSDPILYNVLKKFDGPSDLIPLSKIPVGHSFEFNEKVYKKLEKKRTRSLCMEERSARRYLISEVAQVMLIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB1</accession>
    <name>A0A654DXB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016786">
        <property type="entry name" value="YdeI_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021308">
        <property type="entry name" value="UCP021308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="22613" checksum="82AE1FE440A94009" modified="2020-04-22" version="1">MNPKVDFFFNKTSKWQQEYALLRKIILQTELTEELKWGCPCYTFQKTNVVLIHGFKEYCALLFHKGALLKNTDALLIQQTENVQAARQIRFTSLQQIKDLESTLKSYIYEAIEVERAGLKVELKKTSEFNMPDEFRQVLDEYIELKTAFEALTPGRQRGYLLHFSQPKQSKTRESRIEKCIPRILEGKGLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC2</accession>
    <name>A0A654DXC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22218" checksum="AA6C838605393738" modified="2020-04-22" version="1">MESTQVNIKGMVCSRCIFTIRESLQKAGMFVRDISLGKVTFCKPIDDPQKTTVRSILSGLGFELVSDKRETRFLEIREFIHQWIAAGSGREQGVTLSESLSRHFMQNYDTLSELFSQMEGKSIEKYHIEKRIEVVKESLVYTGKSLSQIAYERGYSSAHHLSAQFKKVTGLNPSHFKQIQRSKGLIVPDHSNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF5</accession>
    <name>A0A654DXF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="17017" checksum="08626617D990F576" modified="2020-04-22" version="1">MNQEKRYPLPPFTMETALEKVQKAEDAWNSKNPINVSKAYTQNSEWRNRTQFINGREEIVEFLTKKWQQERSYKLKKELWGFRENRIAVQFEYEYQDETNQWYRAYGNELWEFDENGLMQKRFASINDLKIDESARRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG7</accession>
    <name>A0A654DXG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024826538" evidence="2">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="412" mass="47071" checksum="CBB3AEA5BB038754" modified="2020-04-22" version="1">MRYLTIVFLLLGSLVSAQTLQEYQQEASENNPMLQSKYKEFEAALQRVTQVKGFPDPTLSVSAFGRMTETRVGRQMARFTLSQMFPWFGTLKVQGEATALIADAAFERYIDEQNKLWFQVSRAYYPLVELEDVLSIQRGNLDILKSWKTLATSKYENGKTSLADVLRVDLMIQDMETEIILLEGMKRPLTASFNQLLNRPDSMEVFTSPFDSVSVPVYSEQVNWNDHPLLKEITLKKQSKEKQYMAIEKQSMPKLGVGLDYIIVAERTDLAAGQAGMNVPGNGQDAIMPMITVSLPLYRRKYKAALKENKLQTESIELMAQSTRNELNASFENVKYDVMREIEMLNLYEIQIEETQRIQSLLVSEFGNSGKDLVELLRIQMQLLNYQKLEIKSKTKLFIALANLDYILGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW3</accession>
    <name>A0A654DXW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellobiose 2-epimerase</fullName>
            <shortName evidence="3">CE</shortName>
            <ecNumber evidence="3">5.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bfce</name>
        <name evidence="4" type="ORF">MARINOS108_11733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>D-cellobiose = beta-D-glucosyl-(1-&gt;4)-D-mannopyranose</text>
            <dbReference type="Rhea" id="RHEA:23384"/>
            <dbReference type="ChEBI" id="CHEBI:17057"/>
            <dbReference type="ChEBI" id="CHEBI:47931"/>
            <dbReference type="EC" id="5.1.3.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cellobiose 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.11" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047736">
        <property type="term" value="F:cellobiose epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00929">
        <property type="entry name" value="Cellobiose_2_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028584">
        <property type="entry name" value="Cellobiose_2_epim"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="389" mass="44988" checksum="9A312FCF589E1A9E" modified="2020-04-22" version="1">MIVKSELYKVLNENVLDFWQSRMVDEEWGGFYGRIDGHDQLHPKADKAIILNTRILWTFSAAYQVTQNSEHKKVADRAYQYIVEHFMDPEFGGVYWTLDHTGHVSNDKKQVYAQAFAIYAFSEYHKIAPQGQALEHAVTLFNLLETHSLDKQDNGYFEAFDRQWGVLSDVRLSDKDMNATKTMNTHLHVLEAYTNLLMVWEHEPLKKALQNLVELMSTKFISDTNHFHLFFNDQWELQSHEVSFGHDIEGSWLLCEAAEVHQDSGLISSTRALALKMTDASLEGMDDDGGLMNEAGPEGLTDTDKHWWPQAEALVGLINAWQISGEERYLREAEKTWSFIKTRLIDPKGEWHWRVTRTGQVVLDEDKAGPWKCPYHNGRALLELYERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC5</accession>
    <name>A0A654DYC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="317" mass="36960" checksum="1F2C512D4F21C5AB" modified="2020-04-22" version="1">MKQPTLSIILCGRNDRYGDDFIDRLKRSLLWNAQLAAKHHIQTELVFINYHPEENQKCISSLDIWPTSDYWNSRVITVRSASDAFLEFPAKNIGIRRARGQYFLITNADILLPELFFYSFHQWIKQSNTIYRADRLNVSRRYNTEAALINTADEYCVKGGIFYRPLMIPHGLYSALLPTYLGARRAVYSCLPFLLTPSEQFLLKHHFTASGDFTLAHRDVWHRIQGFREHTPISTHVDSLWLVKALSHQINLQELPIAVLHQSHERRHNFSSPSQEMNQMWSILQNQISEYLATRTPIVDTTDQWGNPEINYPEDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF1</accession>
    <name>A0A654DYF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="120"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="320"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="395"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="706" mass="79541" checksum="68863B808EA153D0" modified="2020-04-22" version="1">MITKDISKEAKADIKELKDKIQDFNLGRIPEERFKSFRLARGVYGQRQQGVQMFRLKLPFGKITPDQLETVANLSEKYTNGNLHLTTRQNIQLHFVRLQDTPEMWEALESVGVTTKEACGNTVRNVTASPYAGIDPEEPFDVSPYAQGVFEYFLRNPICQEMGRKVKIAFSSSKSDAAFTYIHDFGFIPKIKNGAYGFEVIVGGGLGAQSFMGQLAYDFLPQDELIPFIEAGLRVFDRYGERERRHKARLKYLIEPNKGIGLEGFMKLIEEERKSLKHQTYKINTKKVITKVPEDQSILGVGDFEPNTAYKEWFLTNVFEQKQEGFYAVKVRIPLGDIKSPKARKLADIARTYAAEDIRFTLNQGLLLKYIRLENIPAVYQALQELDYAAPGFDTLADVTACPGTDTCNLGVTNSTALALVLEDLIRDEFPHLVDETLIKIKISGCMNSCGQHMVANIGFHGSSIKNGDKVSPAMQVVIGGGLDPDGKGNIAEKVIKIPTKRIPDTVRTLLNDYEENATEEEYFNAYFRRRGKRYFYDILKHIADVKTLRDEDYQDWGKVDDFVPEIGVGECAGVMMDLVGTILNDAGDRLASGKRTLAEGKWADAIYYSYNTFVIGAKAILLSKDIQCNTHIGIIEDFQKHCVETGEFEGIESFSELVLQINKYEPDEAFAAAYLGQANDFFAQVNNFRSKEAKDKLVVNEFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF9</accession>
    <name>A0A654DYF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Tfp pilus assembly protein PilF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="821" mass="93534" checksum="3C58A70DE133EA11" modified="2020-04-22" version="1">MIIYTQTIHFDYNLDDEIVVSQEDKFSISGLYESISSPYYSLDQRISYGYRPLTSLTFYLESTLLGNNPTISHSINLILYLLVVGLIFLLGLHLFKNPQYAFILALLFAVHPTHTEVVASIKNRDELLALLFGLLAFLSLRLKGNWSIPATIACMICSLLAKKTGLGIYLLAPILLYSFHSKSSAFFCSLVAAMSVSLFAMAPTANVSGSLFLVIIYLTGMTLFFYWAHFNDFKFNKNTLQAGVASLGILVVAFGIFESFVPLILALHIILLASYFFFTSGQLIKWVLFFSLMMTSLFTSAWYFIPMCYVLVFNDYDRTKWIWIPGTLLLFFSVFLVITSTKPFAILFTLIYITPLIFDRLRKKWILLSLLFSAFLAVLINSYAGTSLTYIVLLICFVILFWLLINQKWKSSYLGILICFIALSFYIDSSVTILSGWLQQTQNLGGTPPQTSTTYSGRSLDFIENPLVNHTQISDKLMAMASTYGHYISQMIYPHNLRFYYGYNAIDLFNPPIVLLWLGIITGIITLFMKCAQWRSSLFFILFLVALFPFSNLLVPVAGIVGDRLVFLPSLLFLLFITSLLTEFLSKYSLAIPIVFICAAMGYLSFERAALWKNKETLYLHDASENQLSVKANQLAGDLLYGQAVNAPEIKRKNLLKSALSFYTKGASVHEPYYLNWYMIGVIQLQLTEYKMAMEAFKRAENSPYVDQSIYLQMAICASFLNDLETAEMYYLRAVNHPETKLKAYLNLVYIYLRTDQLSLALSTNQKALDDYPENPSLNENHARIYFNMGDTLNTIKYLENAIYYGNDNERNLEFLESLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI6</accession>
    <name>A0A654DYI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="13866" checksum="6618566327DB3F5B" modified="2020-04-22" version="1">MATITIYLKYSGGDLQYSTDNVTYHDMTETSIVGANPGDTVMWTCADDSIDKINNINVGKTKTAGGNWKDIWSSKPAATDNTKRTYSGVVSTDPESPTNPALNGYDINYKIKNGGNVDKDPTIQVPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN7</accession>
    <name>A0A654DYN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043741">
        <property type="entry name" value="DUF5686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18939">
        <property type="entry name" value="DUF5686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="842" mass="96949" checksum="755F4024D50EB551" modified="2020-04-22" version="1">MHWKLSISLFTLWLCPMLLQGQNTISGMILSESGEALPFATVYVEGSTNGTTSNADGRYQLTIGARPATIVAQYIGYARQTQTIDLPPGEHATINFELAPETLVLKEVVISASEKDPARQVIRNAIRKRKYYADEVSAYTCEVYIKGLQRLDKKPNSLLGMTVTIDTGIVYLSESISKLKYLHPDKVNETMISSKVSGNNNAFSYNQASEMRINLYENSFFIEGLSERSFISPIANNAFLYYDYQMAGTIVENGLFINKIKIIPKRKTDPVFSGYLYIIEDSWRIHSVDVKLTKDNGIEFLDSLSFNQVFAPVDYDIWMPISQRFTFKFRAFGFKGSGHFTAIYRNYQVEPNYWQPRATDPNPVTEIPKKVAKKSPKEPTKETLLSKEDFSNAVVTVVDGANEKDSIYWASVRPIPLTEIEVRDYQIKDSIGVIRKSKPYKDSIDQVRNKFKPGNLFFNGYTHFNSYNRRYFSFPTLVEGLQYNSVEGLVTNLEFSFQKRTEQSFDYTIKPGLRYGFSNKKLQAKVEVTKMINLKKRLILTGGLGRYVFQVNEQEPITPFSNSFFTLVRGENYMRLFQKYFTYFGYQKELMNGVLLNGKLSYEQRETLENTASYNLFDKTFHSNTPVNREMTATDFPKHQTLTTAFRLRIRFAQQYIERPDRKIILSSEYPDVYVFYKKGINLLGGDTNYDLVKVGSEYSLRVGQVGTSKISAQTGLFLNTRRMYFPDFHHFNGNLTYIRQAEGENQFQLLDYYPYSTQDRFLQAHYEHHFNEFIFNKIPGVRRLNLQAVGSVNYLTTPVLGHYFEFGAGIEHILKFFRVDFYTSVTNGRHSRAGIRFGAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ0</accession>
    <name>A0A654DYZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025068043" evidence="1">
        <location>
            <begin position="19"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="72"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="45175" checksum="457426636098E825" modified="2020-04-22" version="1">MKSLFAFILITFCGVVSAQQKLIYAGRLIDGVGDKIQTQKTIIVEDKKIVAVVNGYQAPEAGDVVIDLKNMTVMPGLIDMHVHLEHETSTDGYLKKFTMNEADVAFEAAAFAEVTLMAGFTTVRDLGGTGVNISLRNAINKGVIVGPRIFTAGKSLAITGGHADPTNGYRNDLMGDPGPREGVVNGAADAMKAVRQRYKDGADLIKITATGGVLSVAKDGSGPHFSEGEIEVIVKTANDLGFQVAAHAHGDEGMQRAVRAGVKTIEHGTYMSEVTMKLMREKNAYYIPTITAGMSVAELSRVAGYYPDMVAKKAAVIGPQISETFTRAYKMGVPIGFGTDAGVFPHGENYKEFIYMVEGGMPAMEAIKCATSVNASILGVSDQLGSIRVGLYADIVAVDGNPLDDIDNMGKVNFVMKEGVVYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ06</accession>
    <name>A0A654DZ06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Na(+)-translocating NADH-quinone reductase subunit A</fullName>
            <shortName evidence="2">Na(+)-NQR subunit A</shortName>
            <shortName evidence="2">Na(+)-translocating NQR subunit A</shortName>
            <ecNumber evidence="2">7.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NQR complex subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NQR-1 subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nqrA</name>
        <name evidence="4" type="ORF">MARINOS108_110069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:47748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NqrA family.</text>
    </comment>
    <dbReference type="EC" id="7.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00425">
        <property type="entry name" value="NqrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008703">
        <property type="entry name" value="NqrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022615">
        <property type="entry name" value="NqrA_C_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37839">
        <property type="entry name" value="PTHR37839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05896">
        <property type="entry name" value="NQRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11973">
        <property type="entry name" value="NQRA_SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01936">
        <property type="entry name" value="nqrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0915">Sodium</keyword>
    <keyword evidence="2" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NQRA_SLBB" evidence="3">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD15906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="50204" checksum="771C39033892AC15" modified="2020-04-22" version="1">MSKTIKLKRGFDINLAGKPEKKISESSHSETYALKPTDFINMSRPKLLVKEGDTVKAGTAMLYDKMSEGVKYCSPVSGEVVEIKRGEKRKLLEIKILADKEVVFEKFKTFSTSDLANLSKEEALEQMQAGGVWPNIIQRPFGIVANAEDTPKAIFISAFDTNPLAPDVAFQLGDKEKFFQAGLDVLRKLTPGKVHLNINGQAEVPQVFAQANGVELNKFSGPHPAGNVGVQIHHLDPISKKDIVWTVAPYGVAQIGQLFLEGKYDASKLVAVTGSEVKNPGYVKTYSGVMLEKLFGSEVPTGHLRFIAGNPLTGENCGKAGYLGYYHNQVTVIPEGDYEEFLGWIKPSTKKLSFHKAIGLLSFLSRGKEYTVDTNTHGEDRPFVVSGEFEKVLPMDILPTYLFKAIISEDYDDMEALGIFELVEEDVALCEFIDPSKNEIQKILREGIEMIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ22</accession>
    <name>A0A654DZ22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="44432" checksum="B98E68E877A3681B" modified="2020-04-22" version="1">MKRREFVIKSGVAAAGIATSTLTTAKIIGLNDANNKIKIGVIGTGSRGQGLIPNINSIDHFDVAACADILPFRLEEGLSKVADQQVKGYSDYRKILDDKDIDAVLIATPFSMHANIAMDAIDAGKHVYCEKTMAKGYKDIQDLVSVANRSKKVFQTGHQYHSSRLYTHVVDLIKKGELGRIQAFECQWNRNGNWRRSVPSPDLERIINWRMYREYSGGLLAELCSHQLDFANWVLDATPNKVAGFGGVDYWKDGRETYDNIHLIYDYPEGVKAKFTCLTANSKDDYQIKVMGDKGTLILSYDKAWFYPEGKLNKELGEVDGVSGATVSWDEGKGIPIVVDHIEPSKQALMDFRDNIVNNKRPASNVISGAKAALCVQMGLDAMYDQKIVHWNPDFDKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ83</accession>
    <name>A0A654DZ83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="19745" checksum="4AF43CAA2408A3FD" modified="2020-04-22" version="1">MEKYLIPGRDDVSASDQVLFDTLEKRIGFVPNLYAYYAKNATALTDLLALENRKSSLNAKEKEVVNLVVSQYNGCKYCVSAHTQLALKRGFSDEQILEIRKGSATFDPKLHALAEFSLELSSKNGKVSEATKEQFFEAGYSEANMIDVVVLAGGRTMANYIHNLVGFEIDWPLAPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ95</accession>
    <name>A0A654DZ95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="42649" checksum="D25A08D3DB85A9BA" modified="2020-04-22" version="1">MNIKPADRLAQFSEYYFSAKLRAIRELIAQGRPIVNLGIGSPDQMPHAGVIGALQETAQSGDSHGYQPYQGLPALGDAIREFYARAYQVNVEDKAVLPLLGSKEGIMHTSLAYLNPGDQVLIPALGYPTYTSVTRIVGAEPVYFPLMETSDWAPDWEFLEQLDCSKVKILWINYPHMPSGTRADKALLTRYVDFARSRNILLCHDNPYSFILNDSPLSIFNIEGAEEVAIELNSLSKSFNMAGWRVGWAMGSEKLIQPVLQIKSNMDSGMFKPVQLAAIEALNLDRSWFDGLNDQYRKRQLVGFRIMDLLNCQYSDHQAGMFVWAKAPNGDGEAFVEEILDRYDVFMAPGFIFGEAGRSYIRLSLCASVELLEEVYNRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC0</accession>
    <name>A0A654DZC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024924622" evidence="5">
        <location>
            <begin position="21"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="116"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="322"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="731" mass="81691" checksum="615AA311D3B12976" modified="2020-04-22" version="1">MKSLLILSISLLCVAFGAHSQTITGKVVDENHEPLIGATVLEEGTQNGVITDVEGQFTLTLQSPKSQIHISYTGYKSLVVAAQSGDPIHVILATSEESLDEVVVTGSSTFMDKLEPRHVEVITSAELTKAACCNLSESFDTNASVDVSYTDGVSGAKSIRMLGLDGRYVQINRENIPHVRGLIGRYGMGYVPGTWVQSIDVGKGAGTVVNGYESMSGQINVELQKPENSEKLYLNGYVNSMGRVELNANHAADLTDKWSTAVLLHADYLGNEVDGNEDGFMDLPKSRQLNLMNRYKYVGERVRSQIGIQVMRDEKAGGQVGFGFGDDFQTSPEYGFSNNTTRVEFFGKTGILYPHKPYQGWGLIYSGAYTDIDAGFGRDAYQGTEKTLYGNAIYQNVIGNTFHQYKTGVSILYDDFDESYADSAFSRQEIVPGTFFEYSYLPGDDFTLVAGVRTDFHNLYGTFFTPRLHTRYQITDQTALRLAIGRGYRVGNPLVENTNALVSNRQLVVMENLNPEVSWNMGGSLSSQLSMGGKKIDLIADYFYTTFENQLIYDMDQNSQRVLIYNLDGSSYAHSFQLEAKYQVNEFLGVKGAYKYYDVRSTIDGQLRKLPFISRDRFFLNASYATKYDKWEADATIQWFGTKRLPNTTDKPGEFQRSSETPDFFLVNAQISRGYRWGNIYLGSENLLNFKQDDPIIDPENPFGSNFDASLVWAPIVGRMVYAGFRYKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD7</accession>
    <name>A0A654DZD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="38231" checksum="D6E64213FCAB8F85" modified="2020-04-22" version="1">MKKVVTFGEIMLRLAPEGFLRFSQANSFDVVYGGGESNVAVSLANFGVPVDFVTRLPKNDIGECAMMEMRKRGVNVDKIVWGGERLGIYFLETGAVSRGSKVVYDRAHSSMSTIQPGMVDWKKVFDGVEWFHWTGITPAISQSSADACLEAVKVASEMGVTISTDLNYRAKLWQYCDGAKREEIMTELTSYCDVILGNEEDAEMHFHIKPEGVSVQTEGHNVKAEAFLSVCQQMMKKFPKAKKVITTLRGSISASHNTWAGVLYDGTKMLETRQYQITDIVDRVGGGDSFMGGLIYGLLKYPEDDQNALDFAVAASCLKHTIKGDANLVTVSEVEKLMGGDASGRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI0</accession>
    <name>A0A654DZI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_120111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="DUF1939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024892209" evidence="7">
        <location>
            <begin position="28"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="8">
        <location>
            <begin position="77"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001021-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="486" mass="54946" checksum="699C90D50944C071" modified="2020-04-22" version="1">MKTTFRMMKTKHLSLLLAVLAGGFLMSCEEDDGAENALLDAQNEINVVDVTTHDGRPFSTGVEPQSNAKYVGGPGGGVMMQGFYWDVPAGGTWWNTVKNKTTAWANAGIKAIWLPPVSKAQNGPYSMGYDPTDYYDFGNYNQNGTVETRFGSKTELQALITAAHGQSMEVYADIVINHNSGGQSEANQYTGGNTWTNFNGVASGKFKRTQHDFHPNWVHSNDGGSFGGFPDLCHDVPYVQDWLWGRSDAVAKYYKNTMKFDGWRFDYVKGFEPWVVNSWNNAVGGFSVGELWDSDVNYLNWWANNANSSVFDFAAYYKMNDAFDGNNLNKLNDDMMWKRNAYKAVTFVTNHDTDEIYNKMLAYAYILTHEGYPCIFYQDYETWLDKNKLNNLIWIHNNKATGNTSILYTDTDEYVARRNGYGGNPGLIVYINNSNSWLTRWVPTNWNNTQIKDFTGHSGWYPTTQSGGWVEIQCPPKSYSVWSPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS0</accession>
    <name>A0A654DZS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACP phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008770">
        <property type="term" value="F:[acyl-carrier-protein] phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007431">
        <property type="entry name" value="ACP_PD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38764">
        <property type="entry name" value="PTHR38764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04336">
        <property type="entry name" value="ACP_PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011489">
        <property type="entry name" value="DUF479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="23370" checksum="CD85E44B954DA403" modified="2020-04-22" version="1">MNFLAHIYLSGDQERVMIGNFIGDFVKGKAWEEFDSAIQRGILLHREIDRYTDDHEVVIKTKERLRPKYHHYAPVISDVFYDHFLASLWENYHPTPLLDFTRSFYEVTTHYRDVIPERAQKMLFYMERDNWLYNYQFVEGINRALTGMSQRTPFRSKMEQAAVDLKTDYESYQLEFEAFFPDLVRHSELFLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E003</accession>
    <name>A0A654E003_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">ruvC</name>
        <name evidence="16" type="ORF">MARINOS108_120219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="20291" checksum="98A7936D1715F548" modified="2020-04-22" version="1">MSKDTSLEKIILGLDPGTSVMGYGLIKVKKQDIKLLQFGVIHLSKYSSHELKLKKIFERIIGIIDDYHPDEVALEAPFFGKNVQSMLKLGRAQGVAMAAALSREIPITEYAPKKVKQSVTGNGNASKEQVAAMLKTLLKFNDAPKLLDATDALAVALCHHYQGGKPQQSSKSWKAFLSENPGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E006</accession>
    <name>A0A654E006_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="381"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="51710" checksum="6940C1341D04238B" modified="2020-04-22" version="1">MILMPQVVVSQRNTSFWNVLESKADPQAVHFDIAIDPVSDEIYLATDHGLYKSRPNGDDWQKLSAPTISFFQIRISGQYRYAVAAQGVVYHSQDGGVTWEESQLPDVQEIRDLEVLPNGDVLAATGHMLVKDDVGYFRGNGLFRSADHGATWQKLDIGSFNNRYVVHLAQDSQGNLFASLNEYNSQDGAIIYSPDHGNTWQRIPNPKFNGGDSELLTTNIVQVTSLEVDQRDQLHVSLQGSIGFMATALNLTNSLSGALDQEEWSHLKLTPNGYDWFYNEGYDLFFAENGDIYAPRLGFSFRLSSIFYLDHDERESFERMSLDPVMINDSPYFNFCRFAQRRDGRVFAVQQLDGQVYYTDHSLNPEPVLGVEDPETLQVFIYPNPAQDRLKLVLPETQDTRAVVIYDFTGRMVQHYDHLESQELDLNVSFWPRGLYTIQVLMEDTSKSQKVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E009</accession>
    <name>A0A654E009_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">menB</name>
        <name evidence="4" type="ORF">MARINOS108_11158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="280" mass="31227" checksum="3CA1674EA56D175D" modified="2020-04-22" version="1">MSKPNWKVVREFEDITYKKSGGVARIAFNRPEVRNAFRPKTVGELYQAFLDAREDTSIGVVLLSGEGPSKKDGGWAFCSGGDQNARGHQGYVDDDGMPRLNILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHTVCDLTLASKEHAIFKQTDADVTSFDGGYGSAYLAKMVGQKRAREIFFLGRNYSAQEAFDMGMVNDVIPHEELEDTAYQWGLEILQKSPTSIKMLKFAFNLTDDGMVGQQVFAGEATRLAYMTDEAKEGRNAFLEKRKPDFKDIKWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E057</accession>
    <name>A0A654E057_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="19812" checksum="FEACE4BC4F3866FD" modified="2020-04-22" version="1">MHPSKFTTRKPGAKEHGVIGALMVEVYSQLEGFPTPAEQPKYYEMLSNVGSLTENPHIHLLAAYSPEQVLAGCVLYIGDMQYYGSGGTATQVKDSSGFRLLAVAPDFRGQGIGRLLTRYCIERARKEKRQQLIIHSTKAMQVAWGMYERMGFERSEDLDFRQGTLEVYGFRLPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B2</accession>
    <name>A0A654E0B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ftsK</name>
        <name evidence="12" type="ORF">MARINOS108_120329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="11">
        <location>
            <begin position="504"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="522"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD16649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="863" mass="97230" checksum="CF9B3EB4CECF71DB" modified="2020-04-22" version="1">MLDEGGILHYFCTIHMAQNTYKKQNQSSSKSFNFKLDFLNDRKLHLAVGFFLLLTAFFLFVSFISYLSTGKADQSVVEAFLHTNIKESGQEAQNWFGSIGAITAHFFIFLWFGLSALLIPPFLFLVGHRIIWKKRIVSLTKAFSFSLFYLLWLSIFIGYFMLSSDEVSEWGFLSGGTGFELAIILDGLMGWGALLFLIFLFLVFNMYFFDITQVPVVDDLVLNLKEKAAGIFRKPEPIANDAEDEYSEDEDEPSDETDNSLDFILKKVKEEVEKEEKSQQPAPAPPEEEEEPEDEEVAEVETWTLEDKPKPKKPTPKEEPEFHIELPEDLIEKPKKEEEFSIEVEIPEDHEVRVDHTENYDPTLDLPKYRYPTPELLIDYPQRDVQVSKDELEQNKDKIVETLINFKIGISSIKATIGPTVTLYEIVPEAGVKISKIKNLEDDIALSLAALGIRIIAPIPGRGTIGIEVPNKNREMVDVKSVITTEKFMKSTMDLPIVLGKTISNEVFVTDLAKMPHLLMAGATGQGKSVGLNLIITSLIYKKHPSQLKFVMVDPKKVELTLFNKLERHFLAKLPDSDEAIITDTTKVVNTLNSLCMEMDHRYDLLKDAGCRNLKEYNKKFVGRRLNPQKGHRYLPYIVLVIDELADLMMTAGKEIETPIARLAQLARAIGIHLIVATQRPSVNVITGIIKANFPARLSFRVTSKIDSRTILDTGGADQLIGQGDMLLSMGSDLIRLQCAFVDTPEVDGICEFVGDQRGYDDAYLLPEYVGDNEGSSEVGSVDLSERDSLFDDAARLIVMHQQGSTSLIQRKMKLGYNRAGRLIDQLEAAGIVGSFEGSKAREVLVQDEYALEQLLNDINQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D7</accession>
    <name>A0A654E0D7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_120416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="8">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="19328" checksum="120BE98F5D3134B0" modified="2020-04-22" version="1">MNKCVFLDRDGVINKDYVDYAYSLDRFTILKGVPEAVTLLKEAGYVLVVVTNQSGIAKGVYTRAQMQECHDFMQAELNHQIDKIYYAPGHETYSESLMRKPNTLMFERAVAKFNIDLSQSWMVGDKKRDLIPAIKMGLKTIQVDGHDDQMADFVEPDLLTAAKRILMENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q4</accession>
    <name>A0A654E0Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="426" mass="48767" checksum="04510D6B5D6F2A6C" modified="2020-04-22" version="1">MKRLTVLWTLVLFTLLEANGQMVKGLVKDAETKDPLPFATINFAGTSIGTVSNNDGYFELNIPASCVGKDVQISYMGYASAVMPVRSDSDSPKTILLKPATLTLAELVFRPLSPEDYIRRVVKNMGKSLPKEPFSSMSYYREKFLENGGYLAFTEGVFKSYYTSYQDTIPNQYQLVLYETAENPQEVQFMKSPFDKKDDRRKRKAQKKGEEIEAGDESGIGIIEGTFSGPDEILSMDLSKKLEPFLDSTQFKKFKYRFDDPVIYQGRELLVISFQSKGTVDHLKTKGRIYIDLQSDAFASIDYTGKFVIPFAIEPVLLAFGLTVSNPNITKTLRYQYLNGAWYPEYFHIDVDLELTKIHFFEKNEKSLFEIEQVLKVSDIRENSEKQIPAAKRLDPKKNPKDQVFNDDNARWADFNRLVDEAYTWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T2</accession>
    <name>A0A654E0T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="372" mass="41749" checksum="27BE057FC601737A" modified="2020-04-22" version="1">MHDIIIIGGGLSGLINSILLSRAGLDVLLLEKNVFPFHRVCGEYVSNEVIPFLEAHDLFPAHFLPPSIHQLQISSTKGRSFTAPLDLGGFGISRFVFDQWLAQKSQESGTQILQGTRVLDATFMGEHFLVKTDQNKQYESRLVISAHGKRAKLDQTLSRPFIKEHSPYVGVKYHVKTDFPDNLIALHNFEGGYCGVSKIEGDKFNLCYMVHRDQVRKHGSIKGVENEVLFRNPKLRHLFQNSDFLFSTPEVINEITFVKKEPIYEHLLMSGDAAGMITPLCGNGMAMAIHAASLLSEIILTNKTGDHFDLPAIEARYLHTWNQQFATRLWAGRKIQGLFGKGQASELAVFTGKYMKPMARALIRQTHGEPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y3</accession>
    <name>A0A654E0Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding motility-associated-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024844616" evidence="1">
        <location>
            <begin position="30"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="957" mass="107067" checksum="5EFB2A149D09B600" modified="2020-04-22" version="1">MKNSTVNPFVIKIACWLILLGLSISSAYATHIRAGEITAKRINNLTLTYEFTFTGYRDSGSVIHFGDGIFRFGDSEIQERGFNIVETPIDNEIEMVQFKVVHTYQAANSYVVSYEEKFRNEGIINMDNSVNTTFYVESMIVIDPFFGLNNTPVLLVPPIDFAAVGAKFIHNPGAFDPDGDSLSYKFVIPKQARGAEVNNYRVMNAPEFYTIPNQGNEALNDFAKLTMDPVRGDLEWDAPGDVLNQGDVAEYNVAFVIEEWRQVAGQWFKLGYVTRDMQIIVKKTDNERPELEVPEDLCVEAGETVSEIIQGTDPDGQQVKLEAYGGPFEVNGSSATYKPDPATFQGPPGFLSFEWETECGHVRVRPYEVQFKVTDNPDVGPRLVNFETLLITVVGPSPKGLESSLQTGKSIRLKWDKYNCVNAESMQIWRRVGEFEIEADECNVGMPANSGYRLIDEIPMLDPDTQNPITEYLDNNDGKGLAPGAKYCYRLVATFPLPGGGESYVSEEVCDSIVIDAPAITNVDVLTTSETDGRILVRWAPPYQIDQILYPPDYKYDIFRAEGLNPSATKPYQLIASGITDTVFTDIGLNTFANAYHYFVRFYDAGGVLVDSSATASSVRLALRPLLKSIELNWAASVPWSNTVQDYPYHYIYRDQVVSTDLDQMVLIDSVDVTSEGFYYLDNGDFNGEVLDEDIEYCYAVTAQGSYFNPLLPEPLINRSQIGCGQPNDTIPPCSPPVVTIADQMDCASMLASQPCGSNNYTQSLSWTSDENPDCDDDISFYNVYFTPSGREEDYSIIATPSDTRFDHTDLTSLKGCYRISAVDRSGNESELTEEICNDNCPVYKLPNVFTPNNDGINDVFSPLYKKGLNIASFNDADCPRFVLQVDFRVFDRSGSELYVYNSFENPEGIYINWDGKNKWGQELPAGVYYYVAEVTVDVLNPKDTKWTLNGWLQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E143</accession>
    <name>A0A654E143_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="23517" checksum="85B54EA19718360D" modified="2020-04-22" version="1">MSQKIKISPEEHLRHSLYVHDLLSDYELEDVWRFPVILQSEHSLDQFLTLFRSAGDQLSGKGLAGLLFRFRLFLGKLFHWDEQQPVDHLIPGTLRHRYAGREQLTFEELPDPGTGDFIPVYQLENEFLSEIANKTVEAALHISRVPQDGAWVVHMAVYVKPKGGFGRFYMALIKPFRLWVVYPAMMRAAKKKWENFTKESKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E155</accession>
    <name>A0A654E155_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="18607" checksum="EF9BBBFFC421D024" modified="2020-04-22" version="1">MKTLYIIRHAKSSWSFDLPDHDRPLGRRGRRDVLIIAKHLSENELTPDLMISSTASRALNTALYIADDWGYPEEQIRLDESLFHATSEHLLEVLSNIKEADSVAIVGHNPGFTDLVNHFAEDYVDNLPTCGIYALELNIDNWKDLKSADATKKFLLIPKRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E163</accession>
    <name>A0A654E163_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative addiction module antidote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="74" mass="8152" checksum="37EA4945A238D486" modified="2020-04-22" version="1">MEKSKVTTVGSSVGIVLPKSIQAKLHVKKGDTVSFIETAHGVEITAYDPEFEDQMNAARKVMDDFRNSLNELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L4</accession>
    <name>A0A654E1L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="227" mass="25950" checksum="6E784E2F9685E811" modified="2020-04-22" version="1">MSKPFVLFEDNHLLILSKPTSWLVQGDKTGDKTLTDWGREYIKEKYQKPGDVFLHPCHRLDRPVSGITVFARTSKALERMNKLFREDNIQKTYLAVVQGKPEHESGKLIHWLEKDGAKNMVKAYTKAKGGAKEAELDYQLLANEKAHSLLKVLPKTGRPHQIRVQLSKMGCPIKGDLKYGYADPNTDKSIHLHAFQISFVHPVKKEPVTFTSLPHWNEFKSIIHELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L8</accession>
    <name>A0A654E1L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ORF">MARINOS108_120510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="15841" checksum="93E09DA2E3AAE732" modified="2020-04-22" version="1">MAKEITGYLKLQVRGGAANPSPPVGPALGSKGLNIMEFCKQFNARTQDKQGQLLPVVVAIYTDKSFDFVIKTPPAPILIMEAAKLKKGSAEPNRAKVGSISWDQVKEIAELKMQDLNAFQIEAAMRQVAGTARSMGVRVSGKAPWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P1</accession>
    <name>A0A654E1P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8752" checksum="E18476B8638D483F" modified="2020-04-22" version="1">MTRKASPIFFEGTKIVRLSDLPFAQSTLFSGWLQPVHFIILGERNDYDCVKYEDYEYWYQNYYVGEKDLDNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V3</accession>
    <name>A0A654E1V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="841"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1105"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1363" mass="153898" checksum="DB21DC2AE48A2851" modified="2020-04-22" version="1">MTRSRPFLYAFHILISIALLAILPIKAHGKTISFFSNLSMRDGLPSNIIASIAQDQHDFIWVATGSGLARYDGYKFRVFKKTELSNSLPSNELSTLLADGEHIWVGTWSGLCKINIKTFEITRINLGEPAAIRALFKGKDNALWVGTGNGLIRYDPTSQQYQVYNNQQNGLSHNTVRTIHEDHHGTLWVGTYDQLNILPKGKDQFITIPLPQKNIPGIKNHLILDIQVQKAHPDSMLWVGTETGLFQVSIASRKAERYNGQGRFSNDVIKCIFTDQNNHLWLGTDFGLNIFDPEYETNTVHFHNPQLPYSIANNVIWQIFEDRSGVLWLVTSNGLSRINQYGSFYEYQEISHTVEDQLIGNQVKTILIDSKGIYWLGTQDGVIRINPESGTKKVFDTNSKHRLLLNNVFALEEDLYGHIWIGSAGGINIWDETNEQMHAITANQHNGLSSNYIGKFTKGADGTFWVSAWEGGLYKVDGNLQTLEELLFRPIPDLEAGSAKNVFGNGALWVIEYDELFRADTASLTKEHISTFSEASGKQTIYSVYFSKKGHLWAGTLNGLVQYIPEENRSVFHQVVTGSDEIVSSIIEDEAGNIWSTTNTSLQKLSPPTGEIEHYPLDKDLPLKSFYYGCAARTQNGEIIFGGDNGYIRFAPGKAHPNLFDPKVYITAIEINNRSVGINDQIDGKVLLQRDVAFTQALTLEYEQRSVTFEFSSLHFWQPTMNVFAYKLEGLDEQWNYVSGLKNFAVYSNLPAGKYTFKVKGSNNYGVESTHMASLGLTVKPPLLLSTGFFVLYVILGSLAIFYSLRFYSSRVHLRNELRIIRMEKEHAEEIEQTKEQFFTNISHELRTPISLILPPIHEIQKKGHLDTQSTKLIALAEKNSVRLLRLVNQILDFNKLENETLQIKVAPVDLVKFCQEVFVLFTDQAERQQIHFSFESSHDEHRVWVDAEKIETVLFNLLSNAFKFTHAGGSITLQLRILEDSPPFKEGAFEFRVSDTGVGISEADKTRVFERFYQTKAGRKMDASTGIGLTLAAEYVDLHHGTITVESALGAGTTFTVQLPLGKTHFPIDSVQDEEINLRATRSLYAHQEGAKPYHLDLDSDKPMVLIIEDNTDIIDFIRTSLGHKFNFVVAQNGEEGLQKANNFMPEVIISDIMMPVMDGLTLCEKVKENPKTSHITIILLTAKSMPSNRLEGIKKGADVYLTKPFEIELLEAHVNNLIHRKKELTSYFRNELVVSQDTPETKDNQDNKFLKKVMDLIEANISEPDFGVENISKEIGMSSTHLYRRLKALTNLSAQDIIKKYRIKKASLLLENNEGNVSETMYKVGFSSASYFSKCFKAEFGMTPKEFQRERASASDKSLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V7</accession>
    <name>A0A654E1V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TolB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="319" mass="37255" checksum="E35DB382C6532276" modified="2020-04-22" version="1">MEMRNLIILGLLGLTACQSTEKTTSKETYRIVYNVWHDRENDDYEVFSMKPDGTDRQNISNWEGVDWVYYAYDDKVYFISDRDTTHRMYFLYEMDAFGQNVRKVSDQRLNDSWLSSRKNGSELIVDPRVPGDSAFHIIDLNGKLVFKLYTNLAYYNDPFFSPDGSEVVFRGATKKFKKESGYLDELYIIGANGSGLKKITEYPKNDTLSEWYQYHAGPPFWEPTRNIITYNSVQDGYSSLFMTDPTGKEPKRITPDTLYAAWHAWSPDGQWITFDGYPREYEGDRDFDIYLMEYETGNISRLTSDSTYQQGPVFVRVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y0</accession>
    <name>A0A654E1Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Peptidylamidoglycolate lyase</fullName>
            <ecNumber evidence="8">4.3.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.5" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004598">
        <property type="term" value="F:peptidylamidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044048">
        <property type="entry name" value="Big_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19078">
        <property type="entry name" value="Big_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="LamGL"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="3390"/>
            <end position="3483"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="4732"/>
            <end position="4775"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="4817"/>
            <end position="4861"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="4868"/>
            <end position="4907"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="4911"/>
            <end position="4954"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="4959"/>
            <end position="5002"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="5787"/>
            <end position="5859"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="5936"/>
            <end position="6049"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="6073"/>
            <end position="6144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="6157" mass="643813" checksum="15D42F8BEAF43D79" modified="2020-04-22" version="1">[encoded data, 6157 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z6</accession>
    <name>A0A654E1Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="484" mass="55623" checksum="3664B9FA3C594BF9" modified="2020-04-22" version="1">MQIIFPRPFAIAIDDLGWINGQNDGESGYGPYRLGMNRNITLKDYEAVVDLAQKAGVRLQGLFILSEMDRENFLGAYPTTTHMREKWNNDALISDLQLDIMEFVKKEAAHLEFGLHGVGHEFWPEAGKRRRAEWYNTVDHHPWPEEEIRTHVECYIRILKQYGLSQDNGHSFPESFVPCAYSYHWDPEGPYSSGSILSDYGVRYANTDFTQIPECNPPAEPNGGGFDHRVHVMNRYNYGNLWYEMGKLPTTPLEAQPTDYIETHWPNLLAAEGQSQKDITQRWADYYQAVQATRDRYCAKNTAQMHSQWLYNTYTKVTEASTGVVQIDNTRMPDHVYRGYFPANMVLKVPLKPGEHVSAATIDGTPIPAYIEHEGYGHLYLPQLLQKTYELRYETGTVPLQQVIWHEDTCTIFELTVREALTKIDLCLYGTQELKLRSSREPKQVESNNPAISILRWEMQGDMLVIKAKAHDIQGEIGAIMVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E215</accession>
    <name>A0A654E215_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="36477" checksum="3CBAA953D9F31651" modified="2020-04-22" version="1">MRKRTIIHRHLSYTGWYVRMISFLKSIRISGGKTSLYRALIIFIDKVGDNQLFEKAYGVAFNFTLSLFPSIIFLFALIPFIHEYIPSISQGEILHFLQDILPRSVFEITAETIYDTLQIRREGLISFGVLFALFLATNGVNSLMQTFNMSYKTVENRSFIKTRLIALFLTVLLAFALIFSILFIIIGQVVLDWLLEAGLLSEDFLYYIILLLRFIVVYIAFYLAIASIYYWGPAIHDRWKFFSYGSSLATILCILVSVGFSFYVANFGTYNKVYGSIGAIIALMVWQWLMSFILLLGFEFNASVSRAASGEVYDLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E226</accession>
    <name>A0A654E226_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
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            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024817661" evidence="3">
        <location>
            <begin position="22"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="593"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="707" mass="78865" checksum="10FA4AC44EDC480C" modified="2020-04-22" version="1">MLKMRHSLFVLLLLITWAAQAQVPDTLKTYADTINYYRSTAKAIPELNSNKIEYAPSISADGRTMILESNRRGKYELFDSRLVNGKWSDPKPIDPINNFGDSTDLIGGPSISFDGNMLFFFASFRGGFGSEDIYYSIRDGETWTEPKNIGEPINSSGYEGFPSISADGKTMYFVRQNYNVLQDKDLAKLWENKACFSLYLSKKKKDGTWGQPELLPYPINKDCEKAPRIMADNKTLIFASNRLGGRGDFDLYQTQLTPIGDWKPPVALEFVNTKVADQFSSISAQGDLLYYVYDASEINSVEIPPQLRQFKNIIIQGYITDGKNGAGIAAEIVVSDAFTSGEIMTLSNNPNDGRYTVVLAVGSNYNIEIKKKGYTSKSLFFDLSNEHEYKEIDQDIQLYNTANLNLNIYDGDLFEPIQANIKVKEPGAADFLMQLENNPDGRITLDLPLGKVYEIIVDKENFDSKFFTLDVSDLVVYPEFIRDVEMLPHKRNIEINVADLVNNGKIRSKVRIRNRNRDEVIEVSGNETVALRVGDRYEIEATSDQGYAFNSTVIDVKPSGTEISSGDDAVGGVSVIGEGGSAKIQMNLQPLLVGANLTLKEILFESNSDQLNEVSFAELERVVELMKQNPGMKVEIAAHTDDVGSAAYNAALSNRRAQSAVKFLIEKNIPSDRFVAKGYGESQPIVPNDTEENKAQNRRLVLKILAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E241</accession>
    <name>A0A654E241_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="143" mass="16361" checksum="4023F23FA911AC43" modified="2020-04-22" version="1">MIVSKPITKTLTALSIFLILIFGSFFMLLNSLLSGDSYFIFKLILAPLTLVIGLLVLGKLLAAIKIVKIGDNRIVVFYPITRMKVDIKVPDILGWREEVIKTKNGEFREVKILYTKKKILKLSNRENTEYDAVVKYLKKKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E267</accession>
    <name>A0A654E267_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="212"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="43834" checksum="43F9937451948B58" modified="2020-04-22" version="1">MGIIIPLILIAICCAVIWRAGDGFMTASEYIGRNLSDGVRGATINAIASSMPEVFTSFFFLFIMQDEEGFSGGIGTTAGSAIFNSMVIPAVAVLAVIGMGLTNKVRASKKVMLRDGLSLLIAELLFIILISGSSLDWYHGLLLMLVYVVYIVYMFWSMDKKEREVMLEESHISEEDFEMDQTKQKPFLVGLFTLDLHRVFIGRKKINNLNAWSLLVSATVCIAAVCYLLVLACEWIGDDTYTVPFLGEFQGLGIPVMFVALILASAASSFPDTIISIKDAQRGQYDDAISNALGSNIFDICFALGFPLFVFTLIHGPIAMSQEMVDLSGELRFLLWLLTAVVLIIFVWGGYIGRFKASLLLALYFLFVLYVVGRGAGNEYAQAIADWLVSIVRHFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J7</accession>
    <name>A0A654E2J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34093" checksum="AD6C8C8E722CB943" modified="2020-04-22" version="1">MADNEHNDQIIKWLNGELPEEQLMQEIGADNLLKYKQIIQEVDQWTPDNESVIFDPAVVTKKGKVMTMTRRMSLSVAASVVLVALFSIWMLRSDRTVHFTKAGETKQITLPDGLSIVTLAANSKVSWTEDDWNSSERRLQIDGKGFFQVEKGTPFSVAFQTGEVTVLGTSFEVSEFDESFQVICFEGKVRATDKNQGSRIVSAGEGYLYHHDQWEEKLNVTDTQPSWLQEETKFDNVPLAMVLKTLENEYDIQIIKNNVKLERRFTGSIPNKNLTLALKIVFDPLGISYEMKESKLTLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X9</accession>
    <name>A0A654E2X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="27560" checksum="F77C88E9F3D9096A" modified="2020-04-22" version="1">MKTLIVDDERLARKELMSLLEPHKKIDVVGEATDVDDAIEKINELNPDLIFLDIQMPGKSGFDLLESLDHVPRVIFTTAYDEFALKAFEVNALDYLLKPVQPERLEEAIAKLHVESDRNLSHADAEKRSLGKDDQVFVKDGDKCWFVKLADVRLFESDGNYIKVYFGGNKPMIHKSLNALDERLDDRTFFRASRKHIINLGWVENIDTWFNGGLLVQLKGGEKIEVSRRQAARFKERMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E335</accession>
    <name>A0A654E335_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Lipocalin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13648">
        <property type="entry name" value="Lipocalin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21180" checksum="E2A9412F47CA0FF2" modified="2020-04-22" version="1">MRPSPEGQKLKLIEQMKKWFNLGALLLMVSGSLVFTSCKDDDDDNEPESPLVGVWAYESVDISITINEVDFIDYIIEAFDLTQAEAEAFEEEFIEEMNEFDGMKWTFTKDSKFTVTSSEGNESGTWSLSADNKKLSLTSGTETDVITVKSLTSSKMELFYAEEYEEDMDEDGEDDVFAISMTLKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E392</accession>
    <name>A0A654E392_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mercuric transport protein MerT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mercury ion transport protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MARINOS108_10490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MerT family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015097">
        <property type="term" value="F:mercury ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003457">
        <property type="entry name" value="Transprt_MerT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02411">
        <property type="entry name" value="MerT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0475">Mercuric resistance</keyword>
    <keyword evidence="11" id="KW-0476">Mercury</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22029" checksum="8AE1A43808A7528B" modified="2020-04-22" version="1">MKNKQSNSLAVTSLLTAVSASLCCITPVLALLAGSSGIAAAFSWLDPFRPWLIGITVVVLAFGWYQKLKPKSAQEIACECEDDEKPSFWHSKKFLGIMTVFAAVMLAFPYYADAFYPETQLSISENANLESTYEINITGMTCSGCEEHVKLEIGKLSGISGLEVSYEKANAVVTFDESKTNIDEVKAAVDKTGYKVESINKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A9</accession>
    <name>A0A654E3A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="12154" checksum="367F5185C283CDE8" modified="2020-04-22" version="1">MSWLDRLQARWNLKSSFHVFIVLIVFACTGFTVLFLKRPVVSFFTADGEQNIWFSLAYYILILPIYNLILLFYGFVFGQFRFFWAFEKRMFRRLTGKKDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E9</accession>
    <name>A0A654E3E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="29970" checksum="429B1805E6E8DDF7" modified="2020-04-22" version="1">MKPTLRERQITLKHILIDSRRMIGIKFYPDKVLQALIKTLDNPRWSDEYGLILIENTPKNLRDIFEKFKGVAWINVQHFFTNRPVFAGNSLLSVDGFRQRPGRAGFRYCPEAFYQKLEIRKYSLNTARVYISMFERFINHYQTVENLLELGEQEIINYLQSLVLEGKSDSYINQSINAIKFYYEVVLEMPNRFYRVERPFKKESLPKVISKKSVLRMIDLCPNIKHRCIIALLYSSGLRRAELLHLKISDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I1</accession>
    <name>A0A654E3I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-oxoisovalerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="6880" checksum="6CCED38007FF125B" modified="2020-04-22" version="1">MTEIIFIVEESAEGGFEAKALGESIFTDGETIDELKQNIREAIQCHHETNAPKIVRYLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T2</accession>
    <name>A0A654E3T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S1/P1 Nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="320" mass="37339" checksum="0CBB9C360A3F732C" modified="2020-04-22" version="1">MKGAHKVYLIVLLGAIVSSSWGFFSHQKINRVAVFTLPIEMMGFYKYHIQYITEKAINPDKRRYIMKEEAARHYIDLDVYGDSALYNMPRYWNDAVAMYTEDTLQAYGIVPWHINLVKYQLTQAFLNRDADRILRYSVDLGHYIGDAHVPLHTTENYNGQLTGQLGIHGFWESRLPEVFFEHYDLFTGKAEYIKNTQLEAWKAVESSHLALDSVLRFEKLLTLRYPEDKKYSYEERGATTVRVYSYDFSRDYHEMLNGMVERQMKRAIKMVGDFWFTAWVDGGQPDLDLLINVPATEEEIAPATEQIKLRSHESGEEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W3</accession>
    <name>A0A654E3W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biopolymer transporter TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025019297" evidence="1">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="500" mass="55224" checksum="3C3EBD1AAAA6399E" modified="2020-04-22" version="1">MQKSGLFIGALLMLSITTLAQVQTSKLGVLEATTDVGAPKNTGSTSYNATTQQYTLKGSGTNMWGEKDEFHFAYKKLKGDFILRAHVKLIGEGVDSHRKIGWSVRPTLEGNGTHVSAELHGDGLTSLQSRSEIGGITESLNSTDSFPDVIQLERKAGTYTMSTAQYGKTFTSITLNNVDLGDEVFAGIFVCSHNAEVIEKAVFSNVRIVLPAPDDFTPYRDYIGSNLEVMDIATGQRKILAQFPNSIQAPNWTLDGKTLIYNSEGKLFNFDLATNTSSELYTGFATRNNNDHVLTFDGKTIGISHHSEDDNGQSIIYYLPTKGGDPVRVTPKGPSYFHGWSPDGKELVYTGGRNDVYNIYKISKKGGEETKLTDLTTLDDGPEYSPDGKYIYFNSTRSGKMKIWRMKPDGSEQQQMTFDEYNDWFPHISPDGKSMVIISYPTDIDPADHPFYKRVYLRIMPVEGGEPTVIAYLYGGQGTINVPSWSPDGKKIAFVSNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E417</accession>
    <name>A0A654E417_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4821" checksum="1ECA13BC3A683CA6" modified="2020-04-22" version="1">MLLTFNHTESGELPYWFIILPYAGIIRIRLFGYDLSPIDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E457</accession>
    <name>A0A654E457_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tadA</name>
        <name evidence="5" type="ORF">MARINOS108_50057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17103" checksum="056C998613C7671B" modified="2020-04-22" version="1">MNTLSIHSDEHYMRQALKEAEAAFEEQEIPVGAVVTCQNRIIARAHNQVQRLNDVTAHAEMLAITAAQNFLGSKYLDQCTLYVTLEPCTMCAGALYWSQIAKVCYGAKDEKRGYHLANPDILHPQTTLITGLLADESSELIKAFFRKMRGNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C6</accession>
    <name>A0A654E4C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="41819" checksum="52498B7CD0E18FB4" modified="2020-04-22" version="1">MQNRLNFNFPTPIRFGAGVIDELPDHLLAQGLSHPLLVTDPVVSELEFFQDILNGLRSKNMTPEVHTEMHKNPIESDVLKGGDHYHRSGCDCIVGIGGGVALDVARAIVLRIHHHRPLFDYDDLIGGDQYVTEEVPYFVTVPTTAGTGSEVGRSAIISEDISKKKRILFAPKLMARQVFADPMLTMELPPFVTAATGMDALTHNMEAYLAKNYHPMCDGIALEGMALIAKSIEKATHHPDLEARSNMLLGSLMGAVAFQKGLGVVHSLAHPLSSLLDTHHGLANAVNLPYGMEFNYAGLESRFDKMAEFLGVVDADGARVVDFLFELNQRLELPTKLSEIGVRPEHIEELSNMAVADFAHPNNPKPVSWDDFHTLYQNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F3</accession>
    <name>A0A654E4F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="30464" checksum="0DACE508470C4273" modified="2020-04-22" version="1">MNTWWKANITSPVINRLGRVRERNHFTRPPIFIGGCGRSGTSLLLSMLSAHPGIFAFAKELDAFTEWHQGSTGLVPTRVDRLYRAILTNKIPQQCHRWCEKRPANVRFIPEILEYFGPDARFIHIVRDPRAVCTSIHPEKPDEYWIPIDRYITDVSAGEAMYDHHQVFTLKYEDLVTDYLGQMRKLCDFIEEPMSEEMWRWYDHATVRDNRAWFDGVQEVHSQGLEKWKDHSHHKRVKEITMNAEIRRLMDYFEYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M1</accession>
    <name>A0A654E4M1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">nuoB</name>
        <name evidence="5" type="ORF">MARINOS108_50041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="19598" checksum="DCE98988CB0501BA" modified="2020-04-22" version="1">MGLLDQQFGQGGIIVTKADDLLNWARLSSIWPMGFGLACCAIEMMGAYASGYDMDRFGVLPRASPRQSDVMVVAGTVTFKMADRVRRLYEQMAEPRYVISMGSCSNCGGPYWEHGYHVVKGVDKIIPVDVYVPGCPPRPEALIGGFMKLQEKIRGESLMKPEALKKLMEKRKKATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q3</accession>
    <name>A0A654E4Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglX</name>
        <name evidence="3" type="ORF">MARINOS108_10966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="685"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="766" mass="83873" checksum="6ABD21C9CA87ECD3" modified="2020-04-22" version="1">MDMRNLLVIGIMMISLFLGSCSAPDPIQAGEPYEAQIDSLLNLMTIEEKIGQLNLPGAGDISTGLASNTGIVPKIKAGQVGGLFNISGVEKIRATQQIAVEESRLKIPLIFGMDVIHGYKTVFPIPLGLSCVWDMELIELSTRIAAQEATADGISWTFSPMVDICRDPRWGRISEGVGEDPYLASLMAGAMVRGYQGDDLTAYNTMMACVKHFALYGAIEAGRDYNTVDMSRVRMYNEYFPPYKAAIDAGVGSVMASFNEIDGIPATGNRWLMTEVLREQWGFDGFSVTDYTGINEMIDHGMGDLQTVSALALNAGIDMDMVGEGFLTTLKKSLEEGAITEAQIDAACRRILRAKFELGLFEDPYRYCDIQRSEKEIYTADKRQAARKIAAQSLVLLKNEDNVLPLKKGGTIALIGPLANNKENMTGTWSVAADFTKSISLLEGMKAVGGAHTNILYAKGANVYEEADLEARVSIFGKPTYRDERSADALIKEALAVAQKSEVIVALLGESAEMSGESSSRSDISIPQSQQNLLKALLKTGKPVVLVLQSGRPLAIKWESESVPAILNTWFAGSEGGLAIADVLFGEVNPSGKLSTTFPQNIGQVPIYYNHKNTGRPLAEGQWFQKFRSNYLDVSNEPLYPFGFGLSYSTFEFGDMTLSHQELKGAEVLRVSVPVTNESDVDGKEVVQLYIRDVVGSITRPVQELKGFQKVLIAAGETVTVTFEVTNEDLKFYNSDLEFDWKSGEFEIMVGANSRDVQRQKVNWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T2</accession>
    <name>A0A654E4T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="18968" checksum="D45BEDF0B8930D8F" modified="2020-04-22" version="1">MNYNIAILGLIEIFSAITIGVFILVLTYKIVQWVGRRYYGIESFNVAYSIFMASIILSVGIMVSGIIQPLMSSFRLLDKQSESFIVALKYIGIGGVYIAIAYAAAISIGLISTFLYSKLTPIDEFKEIRENNIGVALVIGSILITLTLFTRDGVMLLIEAIVPYPELPPMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V8</accession>
    <name>A0A654E4V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="409"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="491" mass="55611" checksum="559070782DFC3572" modified="2020-04-22" version="1">MYRKDWASKWAEYTPNKVAVKEYRPARSLTYQELNNQANSLAHYLVHDLKVGKGERLMVLAEHSIEYVALFSMTQKTGITLVPVNFRLSGSEIDYLISDSEPRLLIAERKFADLVSFLKANIEILWLDDLFPQLNNSEHQRFEAVELEEDHPAFILYTSGSTGFPKGAIYSHKMLLWNSLNTSQSLEITPADLTINCMPPFHTGGWNVLVTPMLHRGATIGLMNKFDPDFLLELMEQEKSNLFMGVPTMLKMMADSEKFKSVSLDAMRYFIVGGEALPLEVIDTWHRKGVKIRQGYGLTEVGPNLTSLHQDDAEQKIGSIGKPNFYVEYKIVDEQGRRVEPNEVGEFCLKGPMVTPGYWRNEEASQKAIVDGWFHTGDLVKEDNDGYLYVVDRKKCMFISGGENVYPAEIERVLRAVYGVDEAAVIGVKDAKWGEVGKAFVTMKPGCSFSESLLREHCANHLAKFKVPRYFEVLDELPKNGSGKIDRKNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E501</accession>
    <name>A0A654E501_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructan beta-fructosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="38"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="363"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="495" mass="55833" checksum="4C7CC9DCFAE5B899" modified="2020-04-22" version="1">MKYSTILFAIIFYGCASTVQQKEPIKLSGGEEYRPAYHFTPPAQWMNDPNGMVYFEGEYHLFYQHFPDSNVWGPMHWGHAVSEDMINWEHLPIALYPDSLGYIFSGSAVIDWQNTSGFGTRDNPPMVAIYTYHDPVGADARRIDFQTQGIAYSLDRGRSWTKYQQNPVLENPGIIDFRDPKVSWNEEFQQWTMILAVKDHVNIYSSPDLKEWKLESEFGQSIGAHGGVWECPDLFPLTDENETEKWVMLVSINPGGPQGGSATQYFVGDFDGSVFTPGDSTIRWVDYGADNYAGVTWSDVPESDGRRLFLGWMSNWQYAVAVPTDNWRSAMTLPRELKLLTINDQPVLQSVPVEELGEHFETSSSIDSGGQLESAAYKLELSNIPESGLELIFENNIAEKLTISLSKDELLIDRTSSGLSDFNDLFASVHKAPLPDVEIEKLQIFMDKSSIEVFVNDGLVVMTDLMFPNEVYTSISFTEGLDVKMSSLKSDLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E521</accession>
    <name>A0A654E521_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="44337" checksum="D865B718F8B0D5BA" modified="2020-04-22" version="1">MKKQYLILLLTLGSVVACVKPYDFDPLSYEKVLVIDGAVTNEPGPYEVSITYTFPLEETTAETVADAQVWVMDGAGLRTDFSPSESGVYTSPPAFRGVVGNRYSLFVEMPDGSLYTSDEQLLKASPEIDSIYGKYAQLPNDADEQNVGGIQFFIDSHDDTGETRHYRYEWEEAYKIQVPYPAHYEVVVSDTDTVIVPLDTPKGICYQEYYSNSLIYGTSVGSRENRMAEFPVRFVSEKLPHLRTRYALLVKQYAISESAYLFYKRLRENNESGGSLFDKQTGSIFGNIHAVDNAEQSVLGYFEVSGVSSKRRFFYNRDLDERLRAGHFPYSCLYTERISTVPDSAYYYLQIYDGNIYALYTFPPSVDIYSRGCTDCSFYAEVIPPDYWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E527</accession>
    <name>A0A654E527_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="216"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="48020" checksum="E25A8B618936C7AF" modified="2020-04-22" version="1">MKLVVKITLYFVLISSIVFLIGAVFSYNAISREIDIEERLFLKERLQSVVGFLEHRNPTHEISRDKMVITPLDELVSDSEIVFTDTLVTHSTLNRIEPHLKLDVIRQVNGRAYKIMLYDLIIEEDDIEDAVRESMVKTYLMLLLVSLVLSLIASYYVFRPFQFTLAAIRDFSIKQTNTPKLPISSTAEFKKLNQFIDEMMQKAQRDYRSLKEFSENASHEIQTPISIVQGKLELLMESSELREDQMELISSAQNALKRLSKMSNSLSLLTKIENKEFSDFAPVNVSKLLSELLFDFKELIELKQITLTIDVEPDVEVSGNATLLGILMTNLLNNAVRHNRTGGSLRIELTSTGLDITNTGEPLQGNAQDYFMRFKKGSENPDSSGLGLSIVQQICSEHQFSVIYQTSAEQHHLSVRWESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E550</accession>
    <name>A0A654E550_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15703" checksum="EDF4D4ED35A215BA" modified="2020-04-22" version="1">MFILVFISLSTVLCNCSSRYTNKSISDDDLLAIAKESLRTTDFETQYNPDSSFVLLSTFEETGYSPSTTFVVVRLTKKPKAIYNSGFRGDYLNWTGISTIMIKEKTGLATPMDNGLKTFEIDVVSGDKKEKNNPNDENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A8</accession>
    <name>A0A654E5A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-galactosidase BoGH2A</fullName>
            <ecNumber evidence="9">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_50059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="129"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="264"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="387"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="727"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="8">
        <location>
            <begin position="799"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="916" mass="102236" checksum="E09F6A9DDA9DB473" modified="2020-04-22" version="1">MLKLPGYLVALILLSSISCKQEDTQTAARERISINDDWRFMKYQSSDESDSLIYDVRPEVTDTQDDKAADSKPTEAIEVSTNMAVLKPWILPTGNEFISDPSKKSVRPDGNPGGTYPLVQRDYDDHTWELIDLPHDWAIQGPFFEGWNTPVGGGMGRLPSPGVAWYRKTIEIPKEDEGKSIFLDVDGAMSYAMVWVNGHLAGGWPYGYSSWRINLTPYLEIGGDNQLAIRLDNPPNSSRWYPGGGIYRNVWLVKTDPIHVAHWGTFIKTNNVSSKSAEISLTVDISNNSDASHDVEVVTSIYALENGTSERSFVKKFDRKTLVLSPNARHSVESSVILENPKLWGPPPSQKPNLYLAVTQVIRDHKILDEYETQFGIRSIEFDANRGLIVNGEPVYIKGVNQHHDLGALGAAWNDRAAERQLEMLKELGCNAIRIAHNPPAPELLDMTDRMGFLVVDELYDCWERKKTPLDFHLIFPEWHEQDLRAMIRRDKNHPSVILWSTGNEVGEQYTDEAGARVAAKLRAIANDEDPTRPTSASFNYAKPDMPITAEVEVINLNYQGEGIRNAPAYAHLKGINTPPLYPKFHDKFPDKMIISSENAAALSSRGTYLFPVVDGISAPISDSVGGDPAQGYVSAYELHTANFGSSADKVFSSLDMHPYVAGGFVWSGWDYLGEPTPYYLSRSSYFGLIDLAGFKKDRFYLYQARWRPDFPMVHILPHWNWPDRIGKITPVHIFTSGDEVELFLNGKSLGRKKKKPFEYRLRWDDVIYEPGTLKAIAYKEGKEWSEDMIKTTGAPAKLKLMADRSVINSDGKDLAFITALILDENNLEIPNAAHSVSFTIEGPGNILATDNGDPTDLTSFSSPTRKTFSGKALAIIQSQKGQVVPFRITATSPGLDPYTLTIESAKDGPLKGVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C2</accession>
    <name>A0A654E5C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enzyme</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="36961" checksum="C788CB950A61F688" modified="2020-04-22" version="1">MSKYPLVSVIIPCYNYARYLPECLDSVLAQSYPSWECIIVDDGSEDDTRKVALEYAKKDSRISYLFQKNSGPNAARNLGLEVSKGDFIQLLDADDMLEPDKIRYQVEIHRINPHVDIVYSHHRIFGESFNGHKNQVRSFDTPEVSGSGVEIGRTLLKGPFTINSPLIPKELFRKVGLFNPDFRYNEDWMFWLSCLNAGCKFIFNSQPGGLALVRRHENNTSSNLWNTYYYRIVMRREFSKHSPFFELVNLNLEYLNSDIDFLMNIAIDTLKLDYQKGVKKVFQAFLIKPGVRYLLYLVVAVFNAYWLANILRQKSFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C5</accession>
    <name>A0A654E5C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="187"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="32659" checksum="62C739537C4B980D" modified="2020-04-22" version="1">MAPKKTLSNWLTNRYLLIIRNEENFAEKKTISFNYARVILILTVAFIITLVVSMYMVTVVLEQWLDPRYAMMQSNRQLVDLTMKIDSMEYEMAVKDQYLKNIRMIIGGDVDILQAMGEDPENSTMNPGELGFQESIPPIDSQFRAEFEQQDLGVLTYETSSSEEFRELFLFTPMEGIITDGFNPKKDHYGVDIVARENEPVKCAADGVVIFSSWTLDSGYVLGIQHRGNLISVYKHNSELLKNVGNFVSGGEIIAIIGNTGELTSGPHLHFELWHNGNPVNPQEYVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5R6</accession>
    <name>A0A654E5R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="62" mass="7271" checksum="FF6A3B4342B44218" modified="2020-04-22" version="1">MNIFNLFSSKPKKQLLQDRYDKLMERVYALEMSNLKAAALTRRKAQRVLLQLVELEKTTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Z8</accession>
    <name>A0A654E5Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted alpha-1,6-mannanase, GH76 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="397" mass="44226" checksum="13E85D78FE0B4117" modified="2020-04-22" version="1">MILLKFILILLPLMGCKEESNLDPDENEPKQPVPPSWISRADSSFNSLNLIYWNAEKGVYNTDNKKNLNTQHYWWQANALDAVVDAAVRAKSPSTINQMNEMISGIKNNISSLRNNDFFDDREWMALSILRAYELTENEEYLNDVKGLWEDIKLGWNDNHGGGIAWNENQLDYKNAPSNGPAAILAFRLHKITGSVADLDFGKQILAWQESKLVDPVTGIVWDGIGRQGGTEIDGDNSTEDFWRFTYNQGTYAGALAELYTITKDRQLLVKALKTFSATESLLSSSAGIIRPEGDGDGGLFKGIMMRYFGVLALSEGLSDGERRNVIDYLVDNGESAWDKAKNPAYPFLFNHDWRVSPPINGQGQVSSSVDLTVALSGVFLMETLAVLENKGLLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E610</accession>
    <name>A0A654E610_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21833" checksum="0759A3C4059F248A" modified="2020-04-22" version="1">MKNKYLKAWMEEAVHIPGKIDQHFSGLNEEVLNHKPTPTKWSIGELLDHLIVTNTLYFGRFEKIITQKHSNPLAARFKYLSAFFGQSILKSVHPDNTRKIKTVRKFQPVKKQFTLDKLKEFKDHHSVLMDFALKTDVADHQKTIITSPASGLIFYSLEDAFRIILAHEQRHIQQAVQLLPTSKEMPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6D4</accession>
    <name>A0A654E6D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024836840" evidence="1">
        <location>
            <begin position="22"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="926" mass="103690" checksum="769CD1705A0F3439" modified="2020-04-22" version="1">MKFSTILIGTILTMASWQAFSQTKGPVVTGDYSDTPLQEVFEDVEQQSGLQFFYHQPWVDSVKVTGVFRQTPISTALATILEGSTLSFHQIDGRIIITNNAVVINQPTILHSFSQSSEVSRGIAKGLVFAREYQDQTDDQSDLENYVFEIGNRNSMKTNGSSTIAGYVKSAENGEPVVGALVYLPEPFTATSSDESGFYSLTLPNGKHKIMIQYVGMKTTQRNVVLFSSGKLNIDMDVDVIALQEVTIESDRDINVKSVQMGVNKINIEEVKTVPIVLGENDILKIATTKAGVQTVGEGASGFNVRGGKADQNLILINDAPVYNASHFFGFFSVFNSDAIENMELYKSGIPSKFGGRLSSVFDIQAKSASKTEFKGQGGISPITSKMTLEIPLIKDKTSLLLGGRTTYSNWVLSKVKSAGFNENRVSFYDLITQVDHQIDDKNDLRLSAYVSHDKFRLSSDTLFSFSNFSFDNINGSARWTHKFTNNLEGAFSAIYSDYHYDLQYDESAPNAFTQNFGINEATAKADFDYYMEENRKITFGASVKRYDVNPGQKIPLGQESLIQGQEVARERGIESAIHLASEIEINDFSIYGGIRYVMFNAVGPQKVYTYESGLPKNSDTEIDSAQYGPGEIIKTYHGPEWRFSGRYTLNNASSLKLSLSRTRQYIHSLSNSASLSPTDTWRLSSEHIAPQTADQVALGYYRNMFRNRVEISIEGYYRLLQNLVDFKTGSTYLLNQKIEREVLQGPGKSYGIEFSLTKSGRLNGWLNYAYARTFIKLDGNFQEEIVNDGKFFPTGYDKPHTINLVANYKLTRRFSFSLNTTYNTGRPVTFPVAAFDFKGSQNIHFSDRNAFRIPDYFRIDLGINLEGNHKIQKLSHSFWSLSIYNLTGRDNPFSVFFDVKNGQIQGSQLIVFGNPIPTLSYNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E752</accession>
    <name>A0A654E752_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysD</name>
        <name evidence="8" type="ORF">MARINOS108_20558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="29"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="34707" checksum="3391D171823F2FE5" modified="2020-04-22" version="1">MKSYNLTHLKELEAESIYVLREVFAQFENPAILFSGGKDSIVVTHLARKAFHPAKIPFPLVHIDTGHNFPETIDFRDKLVETLGAKLVVGSVQKSINDGRAAEERGKNATRNAIQTVTLLDTIEENQFDAAIGGARRDEEKARAKERFFSHRDEFGQWDPKNQRPELWNIFNGKQHHGEHFRVFPLSNWTEMDVWQYILAENIDIPSLYFAHKRKVIRRSNTWLPVSDFIQIDPKEEVVEKIIRFRTLGDITITGGVESDADTLEKIVEEVAAARNTERGDREDDKRSETAMEDRKRQGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9W4</accession>
    <name>A0A654E9W4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="12964" checksum="51FCB8A323DCF4CF" modified="2020-04-22" version="1">MIKCLAIDDDPLFLKMLMVLFNDIKSAELIATYNNPVEGMMATVKSKPDVLLLDLEMPYLDGFEALETLDVPPKVIVISGHLNEPRNTVIPISRYISKSEVQSAVMLEAAIKEVMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBD9</accession>
    <name>A0A654EBD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27906" checksum="02944A00C27F3E25" modified="2020-04-22" version="1">MTDVIVAIKRIIKRLITRRSDPQFKRANHQDYLNAYAEFVNKRVARDPHEAIGGYWEELGALQLQFLKAKGLQASHTVLDIGCGTLRGGRLLIDFLEPKKYTGYDISQAAVSFARELIASEGLENKDPRVFWSMKGLADPELRRMKFDVLWAQSVFTHLEPDYIEQHMAQCGALMHEESKFFFTYEEADQFRVEREVDFAYPYSFFEELAKQYGFQLRDLSAQYPHPRGQRILELRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC83</accession>
    <name>A0A654EC83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6265 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046232">
        <property type="entry name" value="DUF6265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19780">
        <property type="entry name" value="DUF6265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062695" description="DUF6265 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6265" evidence="2">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="148" mass="16992" checksum="4652A89B0040C723" modified="2020-04-22" version="1">MKNLLFSSLFFLSFLAYGQSTPNFSWLTGTWTGPGFGGTFEEVWSDPAEDGTIMGMFRHFGEDGTVSFYEFWVLDSTGMKLRHFNEDFTGWETREEYVSFEKVEFSPGKVILKGLTYEQTGPDKMVISLKLTHEGVTRTEVFNMTRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDR8</accession>
    <name>A0A654EDR8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024790659" description="PKD domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="29852" checksum="E641E0F31815233F" modified="2020-04-22" version="1">MRIFFKNFRILSAALLVALVTVSCTEDEEPVAPPVASFSFEVDATNPLSVTFTNATLEGETFAWDFGDGAGTSAEENPTYTYSAGGTYSVKLTATNEGGSNEATKEVTVKDAEPQNQIKNGTFDDDSEWTLQQFNVNANADISIASGVLTIGEVNPDAGWGGEAHGGAWQAVTVEAGTYGFDLDITTDAADEFWAEVWVGDTEPVADQDYNAEVGATVVLAVNTWDCGDAQATYSGSLRDNNCGSSDGTITLTAGTYYVAIRAGGITFPAGGVVIDNVSMFAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE16</accession>
    <name>A0A654EE16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="26282" checksum="2A9E474D6FD0906B" modified="2020-04-22" version="1">MNFNCLIIDDEQPARALIRTYVEKIPGLNILGEFKNPMEAISTISSKRVDILFLDIQMPGLTGLEFIRTLSHKPDIILTTAYSEYALEGYELEVTDYLMKPIAFDRFLRAVNKVIQKKQAPSETPPTNTSEHFLIKSDGQTHRITLTDILYIEGLKEYVTFVLTDKKIIVLESLRKLETELPQEAFMRVHKSFIVNSHRVDSHSGHDLTIGSKKIPIGASYRDEVLNKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEB2</accession>
    <name>A0A654EEB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="2">
        <location>
            <begin position="99"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="408" mass="46710" checksum="B88561F745BEECA3" modified="2020-04-22" version="1">MIEGLLSLPSVFKSMSENSKINFEDTATAFAHKSTARLRKSHFVFSTMNYPWVVKLGTSVTSAALKMRLPVKGLIRNTLFDQFCGGESIEGSEPRMILLAQSNVKTILDYSVEGEASEDGYDEAVEEALRVSEYAKQHVSIPFCVLKMTGIASTRLMERKQKGEQLTPQEEKRFDRVLERIDTIVGRAVQNDMKFMIDAEESWIQDVIDRITYDLMLKYNKEKPYVYNTYQLYRHEALANMKAGFEEVTKAGCYFAAKLVRGAYMEKERDRAEEKGYPDPIQTNKKETDYDYNQALQFAIEHIDKFALCAGTHNEESCQLLVNLMDTHSIKKSDDRVYFAQLLGMSDNISFKLASLGYNVAKYVPYGPVEKVLPYLFRRADENTSIAGQSGREYSLIRKELKRRRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSV4</accession>
    <name>A0A654DSV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="50384" checksum="C11A34E0EBBD2B57" modified="2020-04-22" version="1">MKIIRFIILIGMATSCQTEEKSPINVMTSDIDHFWTAYDLIIKESDSLKRIQLIDSLYIQQGSIGLKKIMEVREYSAEEYIQMITSYPNFLSSLRQNTLKSNELANELSTGIEKLKAVYPNLKPAKIYFTIGCMRSNGTTIDSLVLIGSELAMADQQTNISEFDGATKEWLETFFNSNPIDNLVLLNVHEYIHTQQKTQVNNLLSIAIREGVAEFVSTLAMEMPSATPSIAYGKNNAQGVLEKFELEMFYPNNQSKWFWSNYPNEFGVRDLGYYIGYQLCEYYYTQAEDKEKAIKRMIELDYTNEVEVEDFVEQTRYFSTSLDSLYQRFENKRPYVTGIRQFENNSMNVDAGIRQITIDFSEPLNGHNTGVDFGELGQDYFPKNDVTKRFWSEDKASWTISVELDPGKHYQLLISNNFRTSEDIPLKPYLIDFSTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSY1</accession>
    <name>A0A654DSY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024787276" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="10912" checksum="CFE458C06A68CCAF" modified="2020-04-22" version="1">MKKLAALTVFCFLIVMSTMAQGSGDLKGPEAKNRKPWLDPKPASTVYLVKGESLQGPAAKNVRPLERKTGELVKLDLTTKDKLKGPAYKNYKPWKDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT89</accession>
    <name>A0A654DT89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="20295" checksum="17C36E7885B4BC23" modified="2020-04-22" version="1">MDDQLERFISENRAAFDQEEPSPQVWSEISRKQRRPGIWVGWWKVAAICFLISTVYLIVDRHQSDGGAILEPGDELAEFALVEDYYTSMIAQRKSQLAELSDSELRRNFLLEIQRLDDRYAELKETYTAQNASVMLSDAMINNLKLRIDILDQQLRILKELKDQENENVSQIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTY9</accession>
    <name>A0A654DTY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyhydroxybutyrate depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="91" mass="10399" checksum="C54D0B0BF0AE9095" modified="2020-04-22" version="1">MKRMVIFLWLLLCTVPEALQCERDYGLTAKAIETNWVIVYPEGVPRPGPFEIRTWKAGTCCDYAVANNVDDVGFIRSVIGEMVRTYKKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU25</accession>
    <name>A0A654DU25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="16772" checksum="1DF5E2E0A0DA8A55" modified="2020-04-22" version="1">MKKSRLTTQYPTDFELIGIVSSAKEYQLAWHLNQLNEFHLVKDEDVKIDFAENRQIRVSVLMEETEFRKVYLLKNKLVATNIQTNQFLVQELQQFDFLLKLSSQTDENWANELLLKVKTIPVIDYCLTIDVSKIKMKDNLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU46</accession>
    <name>A0A654DU46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="638" mass="74687" checksum="5140481133EA7EC2" modified="2020-04-22" version="1">MHNNLFLNRMIIHTLNGQIAYDEEYHKGINIIRGDNSSGKSTITHFIFYVLGGAFNDWVKEAKKCQSVTAEVELNGAVVTIKRNIVLNELGKANDKEGIYFFWGSYQKSLTQNDSWQKFNFNTTTERKSFSNVLFENLDLPIVKGENNITFHQVLRLLYLDQESPTSSLFYYEPFDSSLTRETVSDLLLGVYNQELYDKQQREIEADREYDDVRKEIKIIKQFITNPLDLVPSNVVTAIDNKEKEVSEIEEQIIGLREESKRLRYTQKTQLEFEVLNTESIGQREKVNRLKKEIASFRYEIEDTNFFIEALENKRNAIKKSIKTRDLLGEFPLEYCPECLSDLSNHEEEEDRCKLCKQKIDQTFGISQARKIEQELSFQIKESRTLVIKKERQLIDIEANYDAEQVKFHQLQRRVNQALGDVRSHREEKLDSLYVEKGFVEGEIVQLRTLLENAEIYQKLVNREAELKSELEVLSRTISTLKNNRERLKSDINRAIEKKGTYLLNNDLRRQSDFYEAKEFHIDYGNNIAFISDKDAKYSASSSFYLKASARFSIFLASLEIPNMRYPRFIFSDNMEDKGIEEERAQNFQRIIIAESEKFNKDDYQVIYTTSFIPNELNNTAYCVGDYYTESNPSLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM0</accession>
    <name>A0A654DUM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="228" mass="26337" checksum="157E46E38D529EA0" modified="2020-04-22" version="1">MEWIDQLDKLNRINKGTEELWVSGQKIKELTFLKDFRNLKKLFLRSFKTTNLSPLKSLTELKHLELTNVGNGGNLEAISHLTSLQELIIQTPPGWDGGSKRLSYDSLAPLRNLENLVSLTLLDVLFTNDELTPLTHLKSLDQLDTRNTFTTAAFVELNISQPKLKCRYTKPYTIWEGFEYYRCKKCGSMKVEFSGIDLKRRVFCLNCNKKKTDELIERFNEIKAKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU1</accession>
    <name>A0A654DUU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="21806" checksum="F48F2BA7F898508C" modified="2020-04-22" version="1">MSTHPIVGIFNAIAPLNTEIQTRLEQIIAHNIFPKNTALLEIGKKAQSMFFIHKGLARAFYFHDGRDVTDYFATDGQFIGAVPSLFTGLPSQKGIHLIEESDIYHFAAADFEKLCAEYHVIEHIARRMTNFAMIQEQERIESLRFYSMKERYELMEKKYPGIMNRCPLHYIASYLGTTQVSISRIRAGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV29</accession>
    <name>A0A654DV29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="87" mass="10349" checksum="E93F46596387294C" modified="2020-04-22" version="1">MKEREMILRDHLVLDRTKLANQRTLLAFVRTSLYLVVSGIAVIKVDFLDKIRFLGFILVGISLIVLILGVWNYFYFRKKMMNQYHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV38</accession>
    <name>A0A654DV38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="378"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="686" mass="80264" checksum="521EBFEFE60BF0EC" modified="2020-04-22" version="1">MGKNSLFFNILTFDWPKAPITFYFSDQDNGKSQKLHFTLFPNEAESLFPNVVRNSTNELYTTFTGETEGFQPLQIDFKTENPDLIRRYYNRQINFYFRSIQKQIVKVGFVKENQVWLKSRKNETSQWWIYERFSLKVQLNTVSKFPEILLSYDGQSKVSKQSAAELIHQVSPTCFNWVINANQIKRWDWIQNEEEPDYDNCFPVLNKDLEGALGISAEAPPRDNRYPKYLTHIQAFYKKFIDTPKFRELIPLHSGGFMDVPITRIDTTTPESNQLLFGGNNASEVPKFALRDHKPFKPSPYSNIHLFFILHEDDKDMAVKIEEYFRKGYKWFKGMYDYARLLFHTEKGFSIVFKDKENPIPEIERELSNRVINPEVKYIAVYVTPYGKFEYDKEKREIYYQLKEVLLKRNITSQVIDSNKMREQGEGWVYSLPNIAVAMLAKLDGIPWRLNTPHKNELVVGVGAFKHVDEGVQYIGSAFSFGNNGKFNRFEYFLKDELDVLAGSIASSIKEYATVNEDPDRLIIHFYKTMSEKELEPIQEALENLNLSIPVFIIAINKTESEDIVAFDNSWNELMPPSGTFIKIGEAKYLLFNNTRYNGVNYSKADGFPFPIKLKLKCTQPELLQEIRVVRELIDQVYQFSRMYWKSIRQQNLPVTIKYPEMVAQIAPHFVGEEIPPYGKNNLWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA1</accession>
    <name>A0A654DVA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="571" mass="64005" checksum="EC218A81A5D98651" modified="2020-04-22" version="1">MKSIKITVLVLLVALGGCRPEVKKVSQVAISKVKDMPSQPRPYKQLKWREKAINFDQYVFDSNQRGEFMPLIWLDSSNRNVDQTTFGLYTVIGDVRQGYQAHPDFHESLTSLGALMSAGLSGIDKTNQNGFNFVKMSQNYFNSDTGWNIMMNNTNPDVAMLGGGYGRDWWYDVYPNVLYYAVSHLFPGVEGAEEIQRSIAEQFFKADSVLNGNYEYSYFDYAAMRGVNNHIPPQEDAAAGHAYVLLSAYQQFGDEKYLEGAKSAISALANQTESRFYEVLLPFGAYVAARLNAEHGTEYDVLQLLNWSFDGCKAGKGRTGWGVIADQWGPYDVHGLQGSIIDGGGYAFLMNTHSMAWPLVPMVRYQPQYARTIGKWMLNASNSARLFYPYEIDDKHQWLPKKKGLTKNVIAYEGLRKVDAYGKEELAGVEPVALGDGPNWVPGQPEESMFSLYSSAYAGIYGAIINETNVDQVLRLNCLATDFYRADAYPTYLYYNPYQQAQEINFEWDNEEPVDLYDALTHTKVAAGISGYGKFTIAPDESALIVVLPQGAEVTEQDGIYRCNGKIVAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVE1</accession>
    <name>A0A654DVE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="501" mass="55259" checksum="026D34B799E71E19" modified="2020-04-22" version="1">MSKGEEFSNRWGIILASLGMAIGAGNLWRFPRLAGQYGGSFILLWILFLFVWSIPLLLAEFSIGKKYKSGVIGSFGKLAGKRLTWMGFFITFCTLGIAFYYSVVTAWSIEYLSISVINLYDGFMGNTLTDKLASNPNYLLDQWDSLSNGSMVTIGLYILVIVLGVIVVRRGVKNGLEKANRILIPSLFVLLVIVAASALTMENGTKGLEYMFAIKWDNFSNPTIWIEALSQSAWSTGAGWGLMITISSYTRAKEDVTLNTFIGAFGNNTASILAGIAILPAVFALSASDQEATAFLQSGSQSLTFTIIPKLFATIPGGGFMTLIFFLALTLAAFSSFLPMLELLKSNLSTIGVSEGMIAVILLVAFTVFGLPSAYSLDFFSNQDWVWGLGLIVSGIFISVATALYDPVKFKKELIDKDSDFTISNAYFKYAIYVNILLGVFLIYWWMSQGYSTFPWFDAQGSWNWMDVYSNASIVTQWGTVILVGIVINKFLYHRFCKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVG8</accession>
    <name>A0A654DVG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-zinc-cadmium efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="33022" checksum="4EE8DE8A25231553" modified="2020-04-22" version="1">MAHDHHHAHGDHSTSKIRIAFFINLGFSVIELIGGLYTSSVAILSDALHDLGDSMSLGVSWYFQKVARKGRDKEFSYGYRRFSVLGAVINSLVLVVGSILILTEAIPRLFDPTTPDAQGMIYLAIGGILANGLAAYKLHGGHSLNERAVYLHLLEDVLGWVATLIAALIMLYQDWPIVDSLLAIFISLFILFNVYKNLKKALKIILQGTPEEINPKRIDELLRAIPKVISTHDCHIWSMDGQYHILSIHLVVEKYNELQELSEIKQKAKDLLKKEHIDHATIEFETEDEKCDPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU1</accession>
    <name>A0A654DVU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prsA</name>
        <name evidence="6" type="synonym">prs</name>
        <name evidence="8" type="ORF">MARINOS108_11106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="221"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="33659" checksum="2441B060A8CB30CD" modified="2020-04-22" version="1">MSSVKIFAGKGTTELASSIAEQYGKPLGNSTSQKFSDGELNFSFNESIRGSDLFLIQSTTPPSDNIIELLLMIDAARRASAKYVTVVVPYFGYARQDRKDRPRVSIAAKMMANLLTAAGANRLMTMDLHAGQIQGFFDIPVDHLDGSAIFIPYIKSLNLDNLIFASPDVGGTARSRTFAKYFEADMVVCDKHRKRANEIASMQVIGDVEGKDVVLVDDLADTAGTICKAANLLKEKGATTVRAVCTHPILSGKAYENIESSELEELITTDTIPLKQKSDKIKVLTVADLFAKAIKKVHDNESISALFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV5</accession>
    <name>A0A654DVV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="167" mass="18917" checksum="B11574253E75BFB6" modified="2020-04-22" version="1">MKVAIIITDTQVVRFSHLVALELDERLAGLGLNTSILDLADPSYELNELASYDYYLLVGNHAGPLYNHETHRLLTNHRALWRNKKMATVMVTSERILAESADEQLRTVLKSLSANLLPEGLMVMEPEKKFDESFNLIDSVLNLAMYRFLFLLVYGTEAKNGDNRMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW41</accession>
    <name>A0A654DW41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="80" mass="9413" checksum="CDF73FDB6F145F7A" modified="2020-04-22" version="1">MNNAIYLQALIEDQKGNWEQAHDLIQDLTSPEAAWIHAFLHRKEGDVSNARYWYHRANKPFPTVSLSEEWEIIYQTLDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW43</accession>
    <name>A0A654DW43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="31843" checksum="200A41AEB76547EB" modified="2020-04-22" version="1">MIQIDQLSFGYSKQKPLFEQVNLVLPPGNIYGLLGKNGAGKSTLIKMIAGLLYPTQGQIEVAGFQPKDRYPEFLREIYLVAEEFYLPSIRIDRFVKMYSPFYPRFDQERFEGYLSEFQLTQDQKLSALSYGQKKKFLLSFGLATDCKLLILDEPTNGLDIPSKSQFRKVVANAIHEERSFMISTHQVRDMENLIDPIIILDEGQVVFFQDYASVSDKLTFTRQANPPEEKGLIYSESNFGGHIVVKERGSEEETHLSLELLFNAVVSSKEKIRDIFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW98</accession>
    <name>A0A654DW98_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024972637" description="LamGL domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="188"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="38903" checksum="7905271BDD134C54" modified="2020-04-22" version="1">MKTNIKHAMWLLTLAATSIFVACSDGDDPEVVVDKTELNATIQEATDLLANSQEGTAEGQFQLGAKAELQTAVDLAQQVSDSETVTQVQVDNANTALEQAIVTFEGKEVVAIEPDALVGHWTFDEGTGSSTTDYSGNERDGTLSAGHANWGAGTPEWVTDRYGNAAKALHFDKGANVEIPYATALNPQQMSITLWVKGDVVDPIWANNYMISMNRWNGYKFQLQEANKAFMTVKANVDGNPVYYDRDNESPTLDQDVWYHLAVTFGGGEMTFYINGTEVKKWDNTPGTAISIADAPVNLTIGQDLPTGTYSSDDTSPYYVDWGGYFKGTLDEIRIYNKVLSATQVGSIYDLEKPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB7</accession>
    <name>A0A654DWB7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Big_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024915528" description="Big_5 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="423" mass="44398" checksum="F859A29BADB4172F" modified="2020-04-22" version="1">MKTMKLLLVLALMASAMVFISCGDDEGPGALALVSVSATGTDVLSGEATSVDLNGATSASGVPVDLVVTLTFSKEVDAATVSATSVSISGVTADVTASGATVTLTATEELARGTDYTLSIGAIVASDGGEFVATSRSFSTGGVAEVTPPNADAQVAYWKFDGDDTDEMGAFNADSRTKITYVTDRFGQAESTASFDGDESLIQVPGADALMDTDDFTLSFWIKSDGSDVNDNDETRGQFVMGLGAWNGFQFEIFGNYSGCKLASTYALAGGTTGVQDLWWSTTGNLGWQGWTFDQDVSASGGLAAIIKDKWAHVIVSYDAATKIGAIYINGELRKSQDFNLYGETHALYNAVGVAYNGNDAPGNKLAFGFIQGSENRVVTDDWANPVGFPDNNHFKGQMDDVRVFHASFSATQAAELYNAEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWC5</accession>
    <name>A0A654DWC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="21182" checksum="8EB33FC7B1B58A20" modified="2020-04-22" version="1">MIRENPALLQYLAQLHQSNGPVTVTDFHPKTEIISQEKNVKAAFVITAGIAKCFHRENNGKIFVQEFFGPGELFGEIELIRQSLSFSSIEAITQLSAFRMNQEHFHNLLHTDPRFNTLIMETLANKVRYKALRHAHNQSHPAADNLLRLQQSFPDLFHTIPKQDLSDYLGITLRSLNRILKGIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI7</accession>
    <name>A0A654DWI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="36951" checksum="AF8D30D478CD00C9" modified="2020-04-22" version="1">MRDATIYDIASELEISAATVSRAIANNPRISLKTKKLVNEKARELGYRPNKIASNLRSGRGNTIGVILPQIQRHFFASVIHGMEVVLNAHGYNLVICQSNEGLNQEKKAIETLINNRVDGILISNSKETHGNDHLKLINQSGIPFVQFDRIVDDLNSSKVVNDNFSGAYEMVSHLIDQGYSRIAHLSGPQNLKLYRERLDGYACALEAAHIPFDQSLILEAITIDTAEVVAGGIMQSDNPPDAFFAASDLSALGALNYLKCKGYNVPQEVGVAGFGNEPLTEMITPSLTTLEQFGVDMGKSTSKLLLNSIEGNKQSVSVSTLIKPKLIIRESTNRSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR4</accession>
    <name>A0A654DWR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21617" checksum="9E9D82DA92C9010A" modified="2020-04-22" version="1">MAFSDEELIKACCKGERTAQQNLYKKYSGQMYAVALRYSKMQQEAEDILQEAFLKVFQNINNFRQDSSLVYWIKRIVVNTALNHQRSKLYLYPMVDVGDLKNRFTENLTITGINHKELLEMIRKLPSGCQVIFNLYAIEGYKHHEIADLLGISEGTSKSQYARAKSLLKEWILKSDVIYYDRAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV5</accession>
    <name>A0A654DWV5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysM</name>
        <name evidence="13" type="ORF">MARINOS108_11562</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005858">
        <property type="entry name" value="CysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314:SF100">
        <property type="entry name" value="PTHR10314:SF100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01138">
        <property type="entry name" value="cysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="5"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="292" mass="31936" checksum="46D2C03D84E3D348" modified="2020-04-22" version="1">MNLLDLIGNTPLVEITKINQKPGVKIFGKLEGQNPGGSVKDRAAFGMISEALKRGDIKKGDRLIEATSGNTGIALAMIAQSAGLHMTLLMPENSTVERIQAMRAYGAEVILTPAERTIEYSRELAEEKATKEGYFMLNQFANPDNYGMHYKTTGPEIWRDTEGQVTHFVSAMGTTGTIMGVSRYLKEQNPDIQIVGTQPTEGSSIPGIRRWSPEFLPKIFDPKRVDRVIDVSETAARNMARRLAREEAILSGMSSGGALTAALQVAEEIDHGLIVFIVCDIGERYLSSGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX7</accession>
    <name>A0A654DWX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="6253" checksum="9DBBDC509362EC1C" modified="2020-04-22" version="1">MVGSARACADSPTIGSAGYGGSLLKILVMESFEGSNMLLSLPTIQLENGVALGVDRNRQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY1</accession>
    <name>A0A654DWY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="28927" checksum="997A169046875509" modified="2020-04-22" version="1">MKRLSLQTFTIFLSVIVFYSCGPSKKSETSEGTVSAPVKKYTLTKAPASFDYPDAGLALVSSTDNLDTGDVAFEFEVTNYELAVQTPDAETRGIANSGKGQHIHFILNNDPYSAHYESAFTKNIPEGNHVVLAFLSRSYHESVKNGMAYVLKEITVGTPETMGAFDETAQHLFYSRPKGTYSGADTEKLMLDFFLFNTEISPEGNKVRATINGEENYITEWAPYYIEGLGKGKVNVKLELLDKDGNLIPGPFNSVERTVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX47</accession>
    <name>A0A654DX47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GSCFA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014982">
        <property type="entry name" value="GSCFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08885">
        <property type="entry name" value="GSCFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSCFA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="37271" checksum="621F8597A206B629" modified="2020-04-22" version="1">MFTLPFQIPEAPHKIKLKDSIFSIGSCFSDNIGDKLTAHKFDVVTNPLGILYNPFSIFKNLRLLLSEGLDPDNFIEAGGVYFHWDTHSDISGTAMDSFKALLEARSLTSRQSLTSANWLIITLGTIYVYKHLESGKIVANCHKIPQRHFQKLSLSQAEIEEDFFQTMELLRTINPDIKVILTVSPVRHIRDGLIENNVSKATLLQTVNNIVKNDPNIYYFPAYEILIDELRDYRFFKEDMIHPTEQAIQYIWERFITACLDPDAIGFISEWTKVKKSLEHRPFHPDTNEHQRFLRSTLTKLEALSQRVDVSGEMELIKNQLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB4</accession>
    <name>A0A654DXB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="126"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="907" mass="105815" checksum="D07DD2018EDB672F" modified="2020-04-22" version="1">MKLKFVVGYRTQWGQNVYVTGSAKELGKGDARQAVKMQPSSGDLWTAEVAFESTGDFTYHYFLRDESGQEHHEFGEERKLQVNKHFDKIHLRDYWRPQHAFENSLYTAPFTKAFFARGKAVKHKVDLKSSSHFVRLQLRAPRIGRDYQMAVVGSTKSLGAWDESKAVLMSDEDFPVWKVDIPTSAKEVPFEYKFVIYSHKEGRVVTWEGGENRYFPLYTFSLESKLIVHSEEFFHYPVGNWKTAGVAIPVFSLRSKEGSGVGEFTDIKKLVDWSVKTGLKVVQILPVNDTVATHTWVDSYPYAAISVEALHPIYANLQSMGKLKDKKVQLEIDKEAARLNALPEVDYEGVMKLKTRFFKLSFEEKGAAFLKSKEFKDFFQNNENWLPDYAAFSYLRDKHGTPDFTQWGSCAEMSSDALETFVAPKQKHYQDIAIHYYIQYHLDKQLKEATAYARSQGVVLKGDIPIGIYRNSVDAWRLPHLFNMDTQAGAPPDDFSISGQNWGFPTYNWEEMAKDDYHWWRDRMVKMSEYFDVFRIDHILGFFRIWEIPWEHVEGLLGRFNPALPVHLNELRDRGINFDYDRFCRPYIRRHMIYDIFGNYADLVLEEYLHEYKAGCYALKEPFDTQRKIKAHFDELVNNDPESKDFNIWIRNSLYRLHSEVLFLEAPLSDGQAFNPRIGLHSTYSYGELDYDTQQKVDQLYVHFFYQRHNDFWRESAMRKLPMLKGATDMLICGEDLGMVPASVPGVMSELQILSLAIQRMPNDDREFWHPADTPYLSVTSTGSHDMTTLREWWQEDDKQTQRFYNQILGQQGKAPYFCEPWVAHQVINQHLHSPSMLAIFPIQDLIAMDGALRSDTPEKERINVPANPQHYWKYRFHMNMEDLLQEEGFNSFLRQLIDQGGRSADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY7</accession>
    <name>A0A654DXY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="139"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="500"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114578" checksum="A590BC270C2D709D" modified="2020-04-22" version="1">MKRRIQNIVIPIKMVLTCIMCLLCGIGLAEGLPSVEGEKIKVPAQVLDISVSGRVTDSKGEGLPGVSVVVKDASSGTITDVDGNYRLQVPDNAALIFSYVGFITREVKVNYRSVIDVALEENLQELDEVVVIGYGTQQKKDLTGAVSSLSEEDFNVGSISSVEQLVQGRTTGIQISTQSAEPGGNFVIRVRGNNSIQNDNQPIYVVDGFPMDNLDNSINPSNIKSIEVLKDASAAAIYGTRGANGVIIITTKQGKSGAVNIDYNAEYGQQVVSNLDAYEFLGTRAFTENDNLIQRVNGAMEMYSPSRIDSLEQYFGSTNWLQEAFRDGATVNHQLGISSGKENSRVYFSAGYFNQQGVVPSTEFSRYNTRINLNQRMFDDKLTFGLNTGITYTNTNFLGFNASNLQTNILRNIFADARPFVPNRLDNLTETEIQLLGGTRPISPLQTIEASDNEAKSTYILSTGFVELEVLEGLKVKALGGSRMFNGKEYGYLSQESHIVAGTLQPGEAALTNNQSYDLLFEGTINYQKRLGKHGLNLLAGYTNQKVIYESFRAGARDFTTNTLGWNALQAGAIPTTPSSGTSERKLISYLSRAIYDYDDRYLLTLTFRRDGSSKFGANNKWANFPAAAVGWKVHNEAFMSGQSLLSNLKLRASYGITGSERFRVGLAQTQFQANAPVTLDGDNQSIGTVPSVLGNDNLQWEETTQMDLGTDIGLFKDRIVLEFDYYVKNTDKLIVTKSLPPSLGFGSIITNVGRIQNSGVEILLSSNNVTSKNFSWVTDINVSFNSNEIKEVLLPEGSEFLEGAELKPIGQLDRAPYTIIQKGIPVNSFYGYKVRGVLQEGETDDLQPSAVPGDALYHDIDGDSAITSADRTILGHGFPKYLAGLTNTISYKSFQLSFFFSGVFDADVLNVNREIGYRTNRLESALERWTPETPDGTRPFRNHSGQFWVNDDLVEDASFIRLKNISLSYDLPVNKMGLKFVQNLRLYASASNLYTWTNYSGFDPEVSSRVNATTNLNIGSGVDLYSYPLQKSYAVGVKVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY91</accession>
    <name>A0A654DY91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="335" mass="38682" checksum="D41152C215AE5458" modified="2020-04-22" version="1">MRITRKTLIRELKEIFIIALVGALFNFLTSSFTVLNVAVSVTIWVSLSKGNGYIVDYLNTKISWVEKPITRITVGMVCMMAYTIFTFGAVIVLFKWWNSNSELLDLIRNIRFQDFIIAILITLIISMFFHGRAFYINWKEALFKVEKLKNESLKSQYESLRNQVNPHFLFNSLNVLSELVYEDQGKAVEFIRKMSDVYRYVLEHKDQEMVPLDVELAFLTSYGFLQKIRFGDNFDLSIEKNGEGMVPPLALQMLVENAIKHNVVSSAKPLRVEIIISDDTVMVRNNVQEKLTKDSTGIGLSNLKARYQYLSDQEVVISNDQKTFEVTLPLLKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC0</accession>
    <name>A0A654DYC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029095">
        <property type="entry name" value="NarX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13675">
        <property type="entry name" value="PilJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="396"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="596" mass="68156" checksum="523B85C75A33A757" modified="2020-04-22" version="1">MAKLRFKRLGLFYLIALGCIALSIVVSQILIQTSINRQQDDAHVINVAGRQRMLSQKISKLALKIEHQKGERLQNIIALREALALWKQSHEGLQFGDAELGLSGANSSIIMEMFETISPHYEAIYQNAQDLLSLPPDHDDSTALLRADYVSTILAHESTFLEGMDKIVFQYDEEAQKKVRELKETEYFLLVISLLIIIIELIFIFRPLARSVRATVQDLMASEESSRKMTRELSKLYEELGKSYQDLEAVNLEPESPSLYASMSAQGEFMYLAPRFLHMMEYEETEPPKTFQQLLKSSGYKDDFIKGLMLLLQENKNWTGEIRLITEPGDFCWVETFLIPIAITGEIKMISHDITEFKEAKIRSRELNRERIEKSVKEQQYRSVLILEGQEEERKRLSRELHDGVGQMLSAMKLLLESFAPSSNPMKMRLEDAKSLMKSIIQEVRRVSFNLTPSSLDDFGLVPAIKKFCDEINSVTKAKVEFVNETRFINRLESTIETNLYRIIQESVNNALKYAKATHITVRFSHNINSLNILIEDDGKGFDYDRLGSSGHFEKAGHGIFNMKERTSYIGGSFNLTTELGKGTKIFITLSLDKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE7</accession>
    <name>A0A654DYE7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Citrate lyase alpha chain</fullName>
            <shortName evidence="1">Citrase alpha chain</shortName>
            <ecNumber evidence="1">2.8.3.10</ecNumber>
            <ecNumber evidence="1">4.1.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrate (pro-3S)-lyase alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Citrate CoA-transferase subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + citrate = (3S)-citryl-CoA + acetate</text>
            <dbReference type="Rhea" id="RHEA:19405"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57321"/>
            <dbReference type="EC" id="2.8.3.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>citrate = acetate + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:10760"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="4.1.3.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.8.3.10" evidence="1"/>
    <dbReference type="EC" id="4.1.3.6" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009346">
        <property type="term" value="C:ATP-independent citrate lyase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008815">
        <property type="term" value="F:citrate (pro-3S)-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008814">
        <property type="term" value="F:citrate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006472">
        <property type="entry name" value="Citrate_lyase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40596">
        <property type="entry name" value="PTHR40596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04223">
        <property type="entry name" value="CitF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009451">
        <property type="entry name" value="Citrt_lyas_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="514" mass="55491" checksum="5D1B259E8DDD4D4A" modified="2020-04-22" version="1">MVVNAIGRSVPTLVNGKSEIPYKGIGKHRPNGRKFGPLISSCADFPADGNKLVPTLKQALVDAGLKDGMTISTHHHFRNGDLIAIQIFDIAAALGVKDLVWFPSASFDCHAPLIKHLEDGTIHHIEGSMNGQLGRFTTAGKMKGVGVLRSHGGRYQAVQDGEVEIDIAVIAAPSADSFGNANGVDGPAACGLLGFALADSQYANKVIVVTDNLVPFPCVPWHIQGNYVDHVVQLEQVGIPEKIVSGTTAITKSPDRLFLAELTSKFCDQVGIIRDGFSFQAGAGGTALSIGIYFAEMLKAKGMKARFARGGSNKFLVEMLEEGLVEYILDGQTFDLEGVKSMRNNPNHVNTSPFTSYNYHGKGNFAQLLDVVILGATEVDVNFNANVVTHSDGALLHGIGGWQNCLFAKCTILPIPLFRDRIPVVREEVTTICGPGELIDVIVTERGIAINPLRTDLLDKVKDSGLPIRTIHELKEEAERICGVPQKQVFDDEIVAVVKWVDGTILDTIRKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG7</accession>
    <name>A0A654DYG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015305">
        <property type="entry name" value="DUF1961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09224">
        <property type="entry name" value="DUF1961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="31398" checksum="623751CF36BE6B61" modified="2020-04-22" version="1">MWLSSQPYKVFGLHDLMKISIVVLTLMLLGCTTGSQKESSSEPWVEVFSDSCTGDWTDQWFLDGELATIENSREGMTFSAGPVNRDDAHHAVLWTKSSFEGDVKIEYDYTRTDEQEINVNILFIQATGIGEGEFGKDITEWADYRRVPTMSKYWLNMNTIHVSYAAFPMVNEDPGNDYLRVRRYPANSKETFGETEVPPAYERTGLFLPGKTYHLTWTKTKDELTLRVAGDDRDKTYEWDLSGTKPVTEGRIGLRHMFTRSARYKNFKVFTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ1</accession>
    <name>A0A654DYQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase fold protein-3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024935479" evidence="3">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="4">
        <location>
            <begin position="108"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="37954" checksum="6A56D5D2DDFEE572" modified="2020-04-22" version="1">MKNFILFLLTFLTSVSAIKAQSISAENDPSIDPQIREFLKALNNSGGKPLETLSPAEARQVLVSAQQSVEVDYSGIEESEKTITQDGETITIHIVKPEGADANPPVFMFFHGGGWVLGDYATHRRLVRDLVVNSGAVAVFPDYTPSPEAQYPKAINQAYAATKWVAKNGRQIGVDGSRLAVVGNSVGGNMAAVVALMAKDKGTPTISQQILLWPVTDSDFSRASYESFGEERFLTTSLMKWMWDNYTTDVNERKEKYATPIHASIEELRGLPPALVQTAENDILRDEGEAYARKMSEAGVPVTLTRYQGLIHDYGLLNPLAHVPAVQTAIIQAAIVLKEGLDSSNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR9</accession>
    <name>A0A654DYR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated endoribonuclease Cas6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas</name>
        <name evidence="2" type="ORF">MARINOS108_11524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="268" mass="30620" checksum="15C4C617F984FEE6" modified="2020-04-22" version="1">MRVRVTFRVNNRGGLVPFHHQYLISEVFRDILQRESKDDLKDYPFFSFSGIKGQTRLSKAGLHYNSRRVTIVISSLSADFVEHLVGAIFRNKEIQLGALNLTPEMAEEELPVTLHRETKFICISPIVTSDDFHSPEHKLFIEPSSNDFSDQLYDATITRMTEFGIDTDAIPEVHKFQLIPDEDYLDKLRASNKKFSRIYPVYYQGEQLEARGYTFPFTLFAAPEIQDFIFTCGLGTCCSMGFGMLDLVNSDPTERTVPYKSAESLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS7</accession>
    <name>A0A654DYS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="553" mass="61568" checksum="56712EEE56FB8BB6" modified="2020-04-22" version="1">MELFNRTYTLILGIWACSTLTGQAQDLPDLLSNRAIAQANYLPDFSYAGYHFGEDPLPGLTEGEVLYATDFGVIPNDGRDDSKALQQAFSAAHEVPEPVTLQLPPGQIILSEVLYIERSHMVLRGSGSGANGTTIYCPRPMSYFADPPALSELREYLVELDKRQREPENNLDLPFSQYAWAGGVIWTRQPGVRTKAYLDKYDAEPVVLCKVLTGKRGTHELTVSSTKDLKVGQVVQIEWYNTEGQEGSLIKALYGESPLKIGTHHWNYPTHPLVQQRALITRVAGNKVIIKDPLLMDIREAWAPTMVEWLHLEEVGIEHIRIAFPMAPNIAHHVEEGYNAIYLTSLFNGWVTDVKIENADSGILTEEIANVTVSDIETSGEKIAHYSVAMSGVHNVLVQRLRVRNVVRHPLSFNTFSTKSVYADCQVEVAPILDQHAGANHQNLFDNIRVNVSLNGADEYPLFAGGGAGYWKPAHGAYTTFWNIGVTFGDGFETTRVVTLNGMTDGPMARLLGIYANRKIAVVYGPDAYIERVNSRISDIPSLYQYQLDMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX7</accession>
    <name>A0A654DYX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="628" mass="71977" checksum="86B126AF58F819EA" modified="2020-04-22" version="1">MSDPIKHECGVAVLRLRKPLQYYIDKYGSPAFAAKKMYLLMQKQHNRGQDGVGVANIKLDMPPGTRYISRYRTTNQQPIEDIFGKISRKYNKAKKEGGDSFYDAQWMKDNYAFTGEVWLGHLRYGTHGKNGIESCHPFLRQNNWRSRNLVMAGNFNMTNVDELFDKLVSLGQHPKEMVDTVTVMEKIGHFLDEANQAVFNKYRGTKTNIEITDIIEQELDLQRILEKSCRDFDGGYTMTGMLGYGAAFVARDPNGIRPAYYYADDDVVVVASEKPAIKTTFECNYNEIREIPPGHALIIEKDGSYREVKFIEPRVKKSCSFERIYFSRGTDPDIYNERRKLGELLIPSVLKSVNFDLKNAVFSYIPNTAETSFLGLLRGIDNYLIAQRKDIILDQKPSADSLEELLSFRPRVEKLVLKDAKLRTFITDDAHRDDLVAHVYDTTYEVINKRKDTLVVIDDSIVRGTTLEKSILTLLDRLEPKKVVIVSSAPQIRFPDCYGIDMSKMKDFVAFRAVLALLQKHDKEYLLDEVYEKCLASTGDKNQRNFVKELYAPFTYDEVSAMITNIVRPKGMKAELEVVYQTVENLHKACPNHIGDWYFTGDYPTPGGNRVVNKAFMNFMKGSEVRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ1</accession>
    <name>A0A654DYZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative addiction module antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="95" mass="10314" checksum="7216986BEC96B68D" modified="2020-04-22" version="1">MATKEITKFDIAEYLEDDIMIAEYLNTVLEEGDAEDIITALGHVAKARGMSKIAEETGLSRPSLYKALSQGSKPQFDTILKVLRAVGGNLNVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ33</accession>
    <name>A0A654DZ33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="499" mass="55934" checksum="7DCECD762F0D1DE6" modified="2020-04-22" version="1">MNYPPQPGQVGRTKFNKMRSYILFLLVGLSALFSCKEEIERPPNIVVILCDDLGYGDLSSFGHPKIQTPNLDGLAAKGMKLTNFYSAAPVCSPSRVGLMTGRSPNRAGIYDFIIGGNNPRLNNRDIVHMQANEETIPARLKSVGYATCLSGKWHCNSHFNNTEKQPTPDQFGFDHWFATHNNAAPSHENPNNFVRNGEEVGEIEGFSCQIVVNEAMDWLGKQKKDQPFYLQVTFHEPHVPIASPPELVAKYLPYAQNENEAQYFANVENVDIAVGKLVEYLEKNGHDNTLIVFSSDNGPETLLRYSKAIHSYGTTEGLKGRKLWTTEGGFKVPGIIYWMGQPTFNGETDAVVSALDLMPTFCELAGADLPQRELDGQSLTNFLKTGRMTREKPLLWAFYNALNDQVVAMRDGDWKLMARLKYDTAYLPKITNVYVGNIDSVRNAELVDFELYNLAADENEWIDLSADRPEELAKMKATLATEYQALLADSHVWARSETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ82</accession>
    <name>A0A654DZ82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="224" mass="25409" checksum="8645A29B877E8383" modified="2020-04-22" version="1">MTHEDILAKLNSTKSADRKRGAREIGKMKSTALGSDLFEAYLKEKRDKRTWETQVEMIRSLGIIQHKEAISEMEETVMKNKPHDMVTSVASTTFIQLATESVNDARKVIELLKFGSVSVISGSLLSLPTDRMIPSREEIKEVIERSWDINKHPDRIGHEFGLIDSRIYLALQCADWDIEFTSDFLNHCIETAFDISRFGKPVANQNLIAVCENSLKGKFSKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA2</accession>
    <name>A0A654DZA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="40439" checksum="30EF87AC56BEEF6A" modified="2020-04-22" version="1">MNWAKRYGFRISAGVLIFFFLRLGHSEILSEFFVFELIDKILLVYTVGVVLFLWEVLDRVFLYFERKKYDYSRSGDLLKAILILTLLTFPLVVTASGISEFYIKPSLNCPVYEEAIYKEIGQGQIFAWLIIAARIIQLNAVQSRQLEQDKALVQKELLQSQYQNLKNQIKPHFLFNSFSVLQSLIHVNPAQAEEFLSRLSKMYRYILESREESMSTLEKELEILDHYLFLLRVRHEERIEVSIDVDPSKNNFFVPTLSLQMLVENAEKHNRFSKSEPLRIHIFTEGDYLVVQNQVSKKGAEVVSTKVGLENIRSQYDLQSEQSVIVIENDQTFTVKMPILSRFRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA3</accession>
    <name>A0A654DZA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024789831" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="139"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="776" mass="87152" checksum="50FE775F6FE49808" modified="2020-04-22" version="1">MIRGVLLVIFFALTGGSFAQSVVTWQVKDSERAPVLGATVLLESGEVLITNTNGKVSKEISGTEISFQITFVGFKPVQNTFPISGDTTLLIILESDEVVMEAVEIRGNQPRQQLQESGTGYVTFSMEGESELPYLLGEQDPLKFIQSQSGVASGTDGNNGYYVRGGGIDQNAIELDHIELYNTNHLFGFFSTFNPKAIDQVSFMKSGFPAAIGGRLSSMMRIETINPDADAFHGHVKVGVLAGGVSLEIPVIKQKSSLLVAARRSYLDLITQNLMDDESEISRRTDYRFSDLILKYNHRINSHHTLSLVGFMGTDDYLFRSERTFENHIYWKTLNGGVNWKWMTNADLDGEVYATLGRYEQRYGAGLSIYQIDLDSYIANARAGANVFLTRGSHLLTFGAEYSYRNFRPSQVHIESTQEEFNLSEVSWLPTAELAVSVDDEITLTEQLRIGLGLRLSSFVHLGPFTRYETTENLVSVDSTHFSQGEWVQHYVSPEPRVRVNYLMNQNSALKASYDRNVQYIHLSPLGSVSLPTDIWVPSSQKIRPQKAHQVALGYYSLLSSQIKYSVEGYYKLLQNQIEYRNGAIAGYSGSKNFDDDFIFGKGQSYGVEFSVTKDAGSVEYQASYTLSKTERSFEEVQGGETFRAKYDRTHDLNLIGTYHLGNWSFSGLFKLSSGNNLTVPVAKYVINESIVSEYSERNAFRLPMYHRLDVAASWHPSGNEQVTWVFSVYNVYNRRNPYFVYFDVKGDVSAYALDISLKEVALFPVLPSLSFEYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA7</accession>
    <name>A0A654DZA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="31971" checksum="ED068CDD4E240B14" modified="2020-04-22" version="1">MKPFYLIVSMLLIWGCEPIEEGLPTSEQKLVIDGAIEQGQFPIVYLTLSSGFYDPVDSMNLLDLIVTTARVSVSDGENEEVLTLFRNEGYFPPYYYRGTALRGVIGKEYTLEVRSRGETYTATTTIPAPVALDSLWFLQDGPSDSLVNIWVRFKDDGSAVNRYRSFTRIISKNDRYIPAYQSTLSDRAFNGESFRYPILKQPADFTKVAQDVYFTKGDTVNVKFCTLDQVHFDFWRTLERELYSAGNPFGSSGNEVESNIRGTKPALGVWGGYGASYHRIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB1</accession>
    <name>A0A654DZB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase PhyH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="40010" checksum="3C482F5073B55CB6" modified="2020-04-22" version="1">MRFIDQDIEDHFTRNGYCKVQILNGELVEELRHFADKHILSEAIANSDYGMYVSLEEQEEKKALITAFVREKVAPQLDAHLTDFKIHLGGYLIKAPDQVKYTFPHQDWTFVDHETDHTSATVWISLYDIDQSNGTLGFLKGSHRFLNHIIGSPSPAVPTPSMNKELLIFSHLTFENVSAGEALIFNNKTIHAAMPNKSDLHRVAVGIGITPKSAGLYHYYLNPDNPKEFLKLEVEESFFLRYNNDDLMELYRAGLLPELCKVVGSSPVSQHLYPDQSTVEQDILEYGNLPNGHIMDLQNHFGQNEPAEEPSQEPETEEQYVDTRTFFQMYTPLNIYREARYRLTNLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC6</accession>
    <name>A0A654DZC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_12070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="33803" checksum="6A38E3C4D68193BA" modified="2020-04-22" version="1">MQYILDFLRSTTGSKLIQVVIVLTIVFFVVKMLQKGLNKYIKNSTTRYQARKVVSFLGYILALLALMLIYNYKFSNLTLALGVAGAGIAFALQEVIVSIAGFLAILFGNFYKIGDRVKLGGIKGDVVDIGILRTTLMEIGDWVNGDLYNGKMVRVANSFIFKEPVFNYSGDFPFLWDEIGIPLKHSSDHQLARQLMLDITTDLVKEFTLETKTQWNKLTDQLYVENAQIDPMVTMAFDENWITFTIRYVVDFKRRRITKDQLYTRILETIDLHKDKFFIASAAFEVTHMNEPVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV3</accession>
    <name>A0A654DZV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="168"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="46634" checksum="C407485F697C0821" modified="2020-04-22" version="1">MSRIYFFGIAAVLYMAFDLYIYQAIRLVISDYEVVTRRLISVAYFGISAVLFAGIMFYEQLDPKQFQNLRLFITTAFFITLIGKLISAIFLLTDDFRRLVTFVMNMMPSRAEAPKDLSRSEFISKSAIIAGTVPIAVFSFGIVSGAHDYRIRRREIVSSNVPKAFDGLRIVQVSDIHTGSFFNKTAVAGGVDLINQQKGDIVFFTGDLVNNQSEEAKPYLDIFRKIDAPMGVYSTMGNHDYGDYRSWASPQAKQADVHQLQEMHRYMGWDILLNENRLIKEGSDQIAILGLENWGAGRFSKYGDLAKTYAGTEEAPFKILLSHDPSHWDAQVRPEYPDIDLMLAGHTHGMQFGIEIGDFRWSPSQYIYKQWADLYKSGNQYLYVNRGFGFLGYPGRVGILPEITVLELKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M6</accession>
    <name>A0A654E0M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="20617" checksum="150346558D524A43" modified="2020-04-22" version="1">MNRKIQVHYDRLQAGKESLFRQLQPCSEDQLRWKPMGNQWSVLQVLDHLHFAESGSLNYCKKKLLAGDQMPRASLFNSVRMEVYDIILYSRIKIKAPAVVISPSNERNLEEMKSLFDQTSDDLKAFLDEYPDEFLNKGIYKHPMAGRITLPAMVKFFNAHLIHHRHQINRLLHQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P7</accession>
    <name>A0A654E0P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="49937" checksum="6E3B4AD857965F28" modified="2020-04-22" version="1">MEELTEAPVQRRNKITERIPWTDMTRVVIIGGGFAGIELVRKLSKQKVQIVMVDKHNHHTFIPLLYQVATAGLSPGDISSPLREFLQDHKNFHFRMAKVTQIHADEKKIETNLGFLKYDILVIASGATTNFFGNKLLEKKAFKLREMSDAIELRTKLIANFEEALQLDEAEDEALEKFMNIVIVGAGPTGVELAGAIGELQKHVLPLDYPEIDFTKMKIHLIEGADRVLPPMSDKSGRKAAKYLTHFGVNVQYGKLVEKYDGETAYLSDGTSIKTNCLIWAAGVKGNTIPGLREGAVEKGRILVDKFNLVKGHEFIYAVGDVAMQVDEEYPKGLPQLAPVAIQQAHLLGENLKRLFNKEPMKPFKYVDKGTMATVGRNRAVVDAPLNITFGGFFGWFVWMFVHLFSIIGLRRKFLVFLNWVWNYFTYNRGNRLIINKDLEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U6</accession>
    <name>A0A654E0U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY</name>
        <name evidence="3" type="ORF">MARINOS108_120240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13320" checksum="2E62DF8948D2225C" modified="2020-04-22" version="1">MSKTILIVDDSGYSRSTIKGILVNAGYQVIGEAKDGVEALDKIVELDPDLVTLDNILPDMTGLEILRALKEQGISRTVIMVSAVGQQSAIQEGLDLGIKAYITKPFDPKELLEEVKKSFAISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y9</accession>
    <name>A0A654E0Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
                <ecNumber evidence="16">4.2.1.59</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="16">Beta-hydroxyacyl-ACP dehydratase</fullName>
                <shortName evidence="16">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
                <shortName evidence="15">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
                <ecNumber evidence="15">3.5.1.108</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">lpxC</name>
        <name evidence="16 17" type="synonym">fabZ</name>
        <name evidence="17" type="ORF">MARINOS108_11498</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="14 16">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LpxC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="16"/>
    <dbReference type="EC" id="3.5.1.108" evidence="15"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD13490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="51922" checksum="E9EF46EDF103EB03" modified="2020-04-22" version="1">MKVYQQTIRKPITLSGVGLHTGMAANITFKPARPNHGIKFQRTDLKDQPIIEADVDYVIDVNRGTTLEKDGARVQTIEHVLAALVGMEIDNILIQLDSQETPIMDGSAGPFVDAFLKVGIEEQNAQRNFYEIPESIFYQDKSLGVEIAALPLDDYRVTVMVDYSSKVLGSQHASLNKLEDFQNDIARSRTFCFLHEIEELYKNDLIKGGDLSNAVVVVDRKVRPEEVAKLSKLLNKPKIDFYGEGILNDEKLLYPNEPARHKLLDVLGDLALVGRPIKAQILAARPGHTTNVAFARKLKKIMSEASHIHIPQYDPKVPAVLDINKISKILPHRYPFLLIDKIFHLDDEQVAGIKNVTMNEPFFAGHFPGNPVMPGVLQVEAMAQIGGILVLNTVPDPENYWTYFLGIENFKFRKMVVPGDTLVMKLELMQPIRRGFAKMKGVAYVGNNLVCEGIMTASIVRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D7</accession>
    <name>A0A654E1D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase/DNA gyrase B/HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="404" mass="46389" checksum="5304604B8BFA183C" modified="2020-04-22" version="1">MSAYREEPTISLYSNRSSFKWVVLGVALIISAGSIVYTNELVKQIRDRERKQIDLYASTLEYLANENDAPNLIFVMEEIIQANNTIPVILTDEFGKPEHYRNIPAADKIDNDRVRKRFLLNEIKDMMTEREPIMVTLTDDNNQIYGYKNIYYRNSFLLTQLKYYPYVQLSIIAIFGLIIFAVFNYSRTAEQNRVWVGLAKETAHQLGTPLSSLIAWVEYFKETFPDQKDVFIELQKDVDRLEMITERFSNIGSVPQLRQERVFDLVSEVVKYLEKRISTKVSMTVQAFPNEEITCSINRPLFAWVVENIVKNAVDAMVGKGAITIKIMKVSDGRVAVDISDTGKGIAKNRLTQVFKPGYTTKKRGWGLGLALTKRIVENYHGGRIFVKDSELNKGTTFRILLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H6</accession>
    <name>A0A654E1H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplQ</name>
        <name evidence="7" type="ORF">MARINOS108_120470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="21917" checksum="FCC70306B2AAD6A9" modified="2020-04-22" version="1">MRHGKKFNHLGRTASHRKAMLSNMASSLILHKRINTTVAKAKALRKYVEPLITKAKTDTTHSRRIAFSYLQDKVSVQELFGPIAEKISSRPGGYTRIIKTGIRLGDNAEMCMMELVDFNELLLQDSDAAKAKTRRSRRGGKKGGESAETAAVEEAVVVEEPVAEAAVAEEVIEEAAAESTEEEPTNEASDDTEEKEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L5</accession>
    <name>A0A654E1L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011630">
        <property type="entry name" value="DUF1599"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07659">
        <property type="entry name" value="DUF1599"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1599" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1599" evidence="1">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="21101" checksum="D97F820A557F9249" modified="2020-04-22" version="1">MKDRTIHQYREIIASCKEIFAKKTKDYGTAWRILRLPSITDQIFIKAQRIRSIQEKGSQKVGEDIQSEFIGIINYCIIALIQMELSKDDPMEISYEVLEPKYDQAADATLQLLANKNHDYGEAWREMRISSITDIILMKLLRVKQIEDNAGKTIISEGIDANYQDMINYSVFCMIKLKEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z2</accession>
    <name>A0A654E1Z2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">alaS</name>
        <name evidence="12" type="ORF">MARINOS108_10052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="1"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD10439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="877" mass="98528" checksum="69C961E4A34006D8" modified="2020-04-22" version="1">MDSKDIRAQFLEFFKSKSHKIVPSAPIVVQNDPTLMFTNAGMNQFKDYFLGNKTPDSNRVADTQKCLRVSGKHNDLEEVGLDTYHHTMFEMLGNWSFGDYFKKEAIEWAWEFLTDVCGLPEDRMYATVFEGDEKEQLEADEEARGYWKALIPESRILNGNKKDNFWEMGDTGPCGPCSEIHIDLRSEDEVKKVPGRDLVNNDHPLVVEIWNLVFMQFNRLADGSLKNLPQQHVDTGMGFERLAMAVQGKQSNYDTDVFQPIIQSIAKRAGVTYGEDQKVDIAIRVISDHIRAISFTIADGQLPGNAKAGYVIRRILRRAVRYGYTFLNFKEPFLTDLVGQLADQFKDTFPELDAQRVFVAKVIREEEVSFLRTLEKGLKRFEIIKAETKGKVIDGKTAFELYDTYGFPLDLTSLIARENGFSVDEKAFQAEMLIQKERSKSAAEQSTGDWISVISEAEASVFLGYEHLESESRITRYREVKQKKGSFYQIVLDQTPFYAESGGQVGDSGVLESDAERIAVFDTKRENDLIVHYTKALPKDLTATFMAKVNVQKRLLTENNHSATHLLHAALRSVLGEHVQQKGSLVNEEVLRFDFSHFAKVTEEEIAKVEAIVNRRIRENIALDERRNVPIEEAKSLGAMALFGEKYGEFVRVITFDRDYSVELCGGTHVPATGHIGLFKIVSESSVAAGVRRIEAITADKAEAFVDQELEILKEIKELLKNPADPKKAIVSLIEEKNQLQKQIDELNQQQGSALKKDLINKVEDIDGIKVITQEVKLPDANVLKQLSFELKNEVPNLVAVLAANLNEKPMLSVILDDALVQKLGLNASEMVRAMAKEIQGGGGGQPFYATAGGKNLAGLSQALEIGKKIIHEKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E204</accession>
    <name>A0A654E204_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="35418" checksum="252B3B7E8826FC62" modified="2020-04-22" version="1">MKKWWLLGILVLGFFLGRAQSNFFFGHYMFNPSYLNPGWSGSEQQAFVAFQHRSQWVGYSSSFDGSGGAPNTQMLTGIVPIRGFVISSIGINISNDNLGPQSNFQVQLPLTYTLELRKGQLHLGAAPGVFSQTQKFNQLRPNEPDDPLIQGGNEVQTKFNLSAGLFYSSNDGWFIGLGAVNLMRPGFDFGQEGLSNKQELSIAMHGGYSFKINDDLKIAPTALIRSNLTNVTFDLGGIVTLRDKMWGGLSYRRDESAIIYLGYGLLEDNRLKVGYSFDFVFQNQAAKAPTSHEIFIRYDLPDVVFGGRKTVKTPRFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E218</accession>
    <name>A0A654E218_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4581" checksum="248F705476A99FF1" modified="2020-04-22" version="1">MDITNPAVTDGVNLFVNIVIFLVAFGAALSLVDMRKESQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E285</accession>
    <name>A0A654E285_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-antigen/teichoic acid export membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="355"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="492" mass="55616" checksum="573B17C3BF9B3709" modified="2020-04-22" version="1">MGQLRQLASQTVVYGASSVLGRVLNYLLVPLYTAVFSPEDYGVVTELYAFVAFLNIVYTYGFETAYFRFATKSNDARHYFNVAQTSLIITSVLFSGTLVLFSQDIASLLEYPGQGKYVVWLALVLAIDAVVAVPFARLRLEGKALRFATFKLSNIGLNIALNIFFLVFCPWWLAQFPASWVGLVYFPELGVGYVFISNLIANGFYLLFFAPWLVRLKLSMGRDWKLMMLYATPLLVMGFAGVTNEMLSRVLLKYWLPENFYPGQSNQEILGVFGACYKLSVFMTLAVQAFRYAFEPFFFSKSADKNSPELFAKVMHGFIIFGSFSWLVISLVLQDLAPIFLRQPGYLSALDIVPWLLGGGLFLGVYFNLSVWYKLTDQTKYGAWITIIGSLVTIGLNFALIPVLGYMGSAMTTFFSYLLMVCLSYVIGQKHYFVPYKTGKGLFYMALAGLSILAFYFCDLCQEYKYFSATGLIALYVVLVWLLDFRKQTFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A2</accession>
    <name>A0A654E2A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025039678" evidence="5">
        <location>
            <begin position="20"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="39"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="339"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="491" mass="54555" checksum="1667BEE04B7F818A" modified="2020-04-22" version="1">MKYLRIKILSILLALTCLSCENDLTEELKGSLSASTLVSESDARALVDGIYNQMLTGGWFYYGSGQMVKLNDGITDVMVEGRTSNLEQYHWTESHADMVWSSAYVLINRANTALELIEGMDESSFASADAKAALMGEALFLRSLAYFDLTGLFGAVPLRLGATSDPNELPSRTPEGEVYAQLISDLETAAEDLPPVQDGVGKATRGAALTLLAKIAFRQKEWSSAEGYIDQVIDLGVYDLFEGQYGALFYESNRKDNEFIFVVMSLGAEYNKSNHHIKFFTPWGYDTGWSETGVPLQIYNMLDPSDARNDVIENDLSGAYYAYVRDYGTAADWKGFALLTKYSGFRRDVTAPNSIWANYASSALNQPVFRYADILLMKAEVENELNGPTGVAYNAINAVRNRAGLEGLPTGFDQGAFRTAILNERALELVGEGHRKDDLIRHGVFESTMTQYLVDQNYPNPVTVTQDYRVYPIPRQELDLNPNMEPNPLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E9</accession>
    <name>A0A654E2E9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYZ2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYZ2" evidence="1">
        <location>
            <begin position="109"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="31444" checksum="CB6839907E03D2D4" modified="2020-04-22" version="1">MQRPYFRLIAVFALAGLLSCSEPQMVLVLSPTQVTVLHADDILVIDDTLVRPMLYHNLPHFEELPVEESKAKFIGAVLPAILIAKFKIDSVRTEVMALTQKKKWTPTDSALYRTQTERFRAKNISSLLDKMQTHPNSIVLAQAIVESGWGSSRFFQEANNLFGIWSYNTSEPRIAAGKSRNGTRIYLRKYDNISESIVDYFETVARARAYRHFREARKTTSEVATLVPHLRYYSERRDEYVEQLQTIIRQNDLTQYDRHQLDPAYFIPKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N3</accession>
    <name>A0A654E2N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="95" mass="10665" checksum="978B64421A0F1F0E" modified="2020-04-22" version="1">MNDFKPLDPLLHSQLRLAVMSLLLSVESAEFTFIKEKTQATAGNLSVQLDKLSEAGYIRVEKAFRGKKPVTTCQITEQGVEAFERYVNALKGYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R9</accession>
    <name>A0A654E2R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Starch-binding associating with outer membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025011307" evidence="5">
        <location>
            <begin position="20"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="93"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="340"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="685" mass="77158" checksum="39DFAE0CB4568CB7" modified="2020-04-22" version="1">MKRIYILFLISLLTISACADLDIPPPNVVGDETLLTSESGMKVYLARMYSRMPFEDFKYMPQWGFEYNGWLNALGIAGTGEALNRDGICAAFTGERTPYWGQAFTLLRDANYLIETLPEYQSSFPSVTYNHYLGEAYFARAMVFAAMARRFGGVPLVTKLIEYPADAAEADIPRATEEETWDQVLADFDQAIDLLQPTSQERGYANKYVALSFKSEAMLYAGSVAKYNETVPGRLTGFGLKTGVRVIGFDEGSWQTASIRYFREAYAAAQEVINSGAYSLYMNKWVEGDPEAQYQNMVDMFSDLSSSENIYVKEYVYPTVTHGYDAYSAPFIFKAPLASGVCPTADFVELFDGFDRYPNGTLKVTTGNSNTEGDYLMYDSPMDFFSNAEPRLRAYVIFPGDVFKGKEIEIRAGVYTGSEPVEPLFNDYSFAAAETRYQQLSEYTQSPKSLFLSSREGNGQETVNYNGAEMTAAGANGPFYDNGEGCLTGLYGRKWLNDDPSFDAGEGRSDQHFILMRYAEVLLNAAEAAVELSLTGEVAPDGSDLMLTATSAVNQIRRRAGATLLAGNITPDITGRNIVRRERRKELALEHKTKWDVRRWRVQHYEGRDGFWGETRDADQFSNNSRYRFRGLYPFFSTESGQYFFDARFQWVSLKTFEYNVVDYYFAIPGNEVAKSSMIDQQPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E307</accession>
    <name>A0A654E307_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="30"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="515" mass="55375" checksum="4931734ED4110808" modified="2020-04-22" version="1">MSTPSSDMTKILKNLGVEASNPGAAIGSKWLPTKGEVITSFSPVDGKAIAEVRLADADAYEKVVRAAQEAFLEWRLVPAPQRGEIVRQIGLELRKHKDDLGTLVSYEMGKSLQEGLGEVQEMIDICDFAVGLSRQLYGLTMHSERPLHRMYEQWHPLGIVGIISAFNFPVAVWAWNSALAWVCGDVCIWKPSEKVPLSAIACQKIVQGIFEKNGVHPGVCGLIVGDAEIGKRMANDTRVPLVSATGSTRMGKAVGEAVGRRLGKSILELGGNNAIIITENADLNIAIPGAVFGAVGTAGQRCTSTRRLIIHESIYEDLKQRLQSAYGQLRIGSPLDQNNHVGPLIDKDAVQMYESALTKIAAEGGKAVIAGEVLSGPGYESGCYVKPAIYEVKNDYEIVCHETFAPILYLIKYSTLEEAIAMQNAVPQGLSSAIMTTNMRESELFLSQAGSDCGIANVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAYMRRQTNTINYSTQLPLAQGIKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E352</accession>
    <name>A0A654E352_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized ABC transporter ATP-binding protein YfmR</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfmR</name>
        <name evidence="6" type="ORF">MARINOS108_110048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="317"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="627" mass="71873" checksum="EA3DB6F51F503132" modified="2020-04-22" version="1">MNNLSVENLAKNYDERQLFENLTFGLEQGQKAALVGVNGCGKSTLLKIIAGIEPPDRGEVSFRKGVRVAMVPQSPEFDDNDNIVQAVFAEDIEELNVIRDYEIAIHKATVDPENAPDLTDVLERMDQLNAWDYESQVKQLLGELGLHDLEQKMGELSGGQRKRVALARALVVKPDFLILDEPTNHLDLDVIEWLESYLATANLTLLMVTHDRYFLDRVTNEIMEIDQGELFRYKGNYQNFLEKKAEREAQDAATVDKAKNLLRKELEWMRRQPKARGTKAKYRVDAFYETKEKASKGIQRAEMEVNLKGERQGKKILVMEHVSKRFDKIKILENFEHTFQRKERVGIVGPNGVGKSTFLNLLIGNILPDSGNMELGQTTKFGYYTQEEQIFNPNSRVIDVIKEVAEVIKMADGSVITASQLLNQFLFPPKMQFNMVGKLSGGERRRLQLLRVLMNNPNFLILDEPTNDLDLMTLNVLEDYLDNFEGCLMIVSHDRYFMDKLTDHLFIFEGEGQVRDFPGNYTDFREQGGKLAKKEEAPKKSTDKSPAPAEPVKTEKKKLSYNEQREYDKLEGEIAKLEKERDAKTALMNQKTDFEELQKLAEELEAIRDSIEEKEMRWLELSDKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E361</accession>
    <name>A0A654E361_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="20332" checksum="981AD56E191DD79A" modified="2020-04-22" version="1">MNSVRLRIVKTTLEDFPEVRKLFEMTKTHQQKAGYKVWEEIDYSDVQKEIANSNQHKIVVADAMAGIFSVQYEDTFIWGVRDKQDAIYLHRIVIEQSHQGQRLFENLLAWAKGHAKGKGRRFVRMDTWADNARLIRYYQSFGFERVDEVTTGNNPELPIQNRNLNVVLLQFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E394</accession>
    <name>A0A654E394_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase 1</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17143" checksum="F093F39D74913173" modified="2020-04-22" version="1">MAIEIGSYEEFTEYIGKDLGQSEALEITQEQINKFADATLDHQWIHVDEERAKAGPFGQTIAHGYLTLSLVPHMWAQILTAKNLKMMVNYGLNNLKFNQPVPVGSKLILKAHLESLTNLRGITKAEVGARMEIEGNPKPAYTATMILLYHFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E398</accession>
    <name>A0A654E398_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prfB</name>
        <name evidence="6" type="ORF">MARINOS108_20732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="36693" checksum="F3D2E74D9570D0BA" modified="2020-04-22" version="1">MVTAQPDFWNDPQNAETTMKAIRAKKTWTDHFEQVAASVEEAETLQEFLNEGEGTEAEVNAAYEKALSDVEELEFKKMLSGEEDQLSAMLQINPGAGGTESNDWAGILMRMYIMWGEANGYKVREVEFQAGDVAGVKSVTLEFDGPLAYGFLKSENGVHRLVRISPFDSGGRRHTSFASVYVYPVVDDSIEIDIHPNDIEMHTSRSGGAGGQNVNKVETKVQLTHKPTGIVVVCQVERSQLANREGAMKMLKSQLYQMEIEKRNAERDKVEAGKMKIDFGSQIRNYVLHPYKLIKDARTGHERTDVQNVLDGDINDFIKTFLLHQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B0</accession>
    <name>A0A654E3B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025020889" evidence="1">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="26554" checksum="B75F8CA359FEF289" modified="2020-04-22" version="1">MTLQAIKPFVFLYLMASLTACNEGELMSAAELIITVEDAQGNKVTTAEVYLYESLTAFQNETSSVTAGLTNTAGYLQLKNLSPGQIYYLDIQKGSATNWIHQTTSVVIQEGLNEFSTILTENWYSNLSSVGGKVWSPKFILQNEQWVQYDDCFNDDQYQFYKNFDMDFRNNTKCVGSTEDFFTGQWFGSATQLSIYSDAAESAGLSFKLLESSPDHFVGELRATSGQLITVYFGKTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D2</accession>
    <name>A0A654E3D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Co-chaperonin GroES (HSP10)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14490" checksum="8AA2496EAF971EE7" modified="2020-04-22" version="1">MRTQLTAENKLKNIIVVGDRVLIRPKAESEKTSSGIYLPPGVQEKEKIQTGYIVKAGPGYPIPVSADEDDSWKQEEERVKYIPLQARAGDLAIFLQKGAFEVVYEGEKYFIVPQSSILMLEREEDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J1</accession>
    <name>A0A654E3J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="38541" checksum="C4C2147C94E50C8A" modified="2020-04-22" version="1">MTNINAALLSFGMSGKVFHAPFLHLHPGFTLLGSWERSTKAIADQYPGTHSYDSLEAVLADDRIELVVVNTPTYTHYEYAKAALNAGKHVIVEKAFVGCTAEAVELQALARAQGLKLAVFQNRRWDSDFKTVQNVVRQGLLGDIVEASIDFARYTPQLSPKTHKEKPSAGAGIIKDLGAHVIDQALCLFGMPRSVFADIATTRVDSQVDDYFDILLKYDKMRVHVKGGYFFREPTPSFAFFGTKGTFLKSRADVQEDQLKAGMKPNDPQYGVEPDTEQGLLHTEVEGKVIRENIQTLPGDYKEYYEAVYQSLTSDLPEPVTAQDGVNVMRIIDAAFESAEQGKVIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R4</accession>
    <name>A0A654E3R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="93" mass="10109" checksum="F132D9024E7536C4" modified="2020-04-22" version="1">MLGKNTNIKRGQAKTLLIILGVIIALIMTMNSPIFTADNINMPAPEHQEQVAEVDANEAESQPTSGSSSGAKFNSGTRLLHIFTRNLPYLNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W0</accession>
    <name>A0A654E3W0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="896"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="771"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="963" mass="109654" checksum="3128F2BE6EADE90C" modified="2020-04-22" version="1">MIILDRMKKVISLIFSGMLIAQIPQAQPAAPSEIQILGKPRIRHYDRGDFHGDTQFWAACEDSLGVLYFGNNDGTLIFDGTRWQNITFPNNSSTRSLHFAQNGTVYMGGFGQFGAVSKDGFGNYQFESLLDLLRQEDQNIENVWDICEYQGSVIFRTYNKLLALKNNQIRVIPTEYAYYSNVVNGQLLIADADGLKVLELSSINFSTLVTQEELDGSEISSILPGRNDHEMLITTKKGTLFSFSGHKLTRMFSLVGGQSEYQLITGIKSKNEIYYFGTLNDQIISLDKNLNLLESGKDYWALQDNTVLKLFETRKGNVWALLNNGLDLLNTSSASTILFEEASVFDVEINRNTLYMATNQGVFKSTVSENRKPLNMTHLLEGQAWSLQSFEGKVLCGHDRGLFEISETGITRIGNITGVWKIIKIAQQQNKYLVCTYDGLILMEYSDGEGFVLNQKIAGFNESGRDILQAEGEGVFWVCHGYKGIYRLKLDKSFTRVLALEHFREKGLPSPFNINVFKWQGKTVFTTNHGIFQFNESTDLFEPFTPLNQAFGQEKNVRKIIEAGNKTWFVLDDMLGYFEGDGSGGLQLDPFLELKGSFNRGLECIYPMHQSVLIGTTEGLFAYDLNALRQTENQTVLTKVTFRVGSEIKEAILNAAEPISLPNNVSDITFEYAVPGMSDPETVQFRYRLSQAWSEWDAQPVKQYEQLNPGKYTFEVGSRSLLGETGTIAKYAFRIMPVWYKTNWAYLAYACMGGLVLLSFRKLIKAKISREKTLTQQEEQEKRNLLELELERIKLASEKEKIELEKQMLEQDVVDKSKELTNYTMLLAKKRELITNIKEALKDLKKSARTEANRTSIREIVRSINMHLNDEEYLKVFETNFERVHKDFFDELKANFPDLSPKELRLCALVRMNLTNKDIAPILNISIRGVETARYRIRKRLSIDHDENMASFLDKLADANQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W1</accession>
    <name>A0A654E3W1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA</name>
        <name evidence="9" type="ORF">MARINOS108_20610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="191"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="46094" checksum="0B48C4A6B54DA0C1" modified="2020-04-22" version="1">MAYIEPAPIKDKGNPFESMMSRFHIAAQHLGLDDEVYNVLKSPTKQVIVSLPITMDNGSIQVFEGYRVIHSNILGPSKGGIRYDMDVNLDEVKALAAWMTWKCAVVDIPYGGAKGGIKCNPRAMSAGEVERLTRSFTQSMLEIFGPDRDIPAPDMGTGPREMAWLMDHYSRAQGMTVNSVVTGKPLVLGGSLGRTEATGRGVMISAMAAMEKMKINPFKATCAVQGFGNVGSWAAILLAERGVTVVSVSDLSGAYYNKEGINIKEAINYRNENNGSLEGFAGAEKIDPDELLLLDVDVLVPAAVEDVITEKNAGQIKAKLIVEGANGPTSAKADAILNDNGIMAVPDILANAGGVTVSYFEWVQNRLGYKWTAERVNRRSDRIMKTAFDKVYETSQQYNVSLRIAAYIVAIDKVAKTYKYRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E431</accession>
    <name>A0A654E431_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025072600" evidence="1">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="45952" checksum="991747250919620C" modified="2020-04-22" version="1">MKKLLIFACCLTWMFSARAQFNAKIPIDSNYSILSNPFIQMESTEAINDMYNFRFERSMSHFNYLRKEYGWHPLPYFLMGLNYWWRILPNFNNEEYDKAFHAYMDTSMILAERLYKDLNKVEGAFMLAATYAFQGRLYSERREWGKAAYAGKNALKYLEECKGYGDLSPELLFGDALFNYYREWVPENYPFLKPVMAIFPDGDKEKGIEQLKIVARNAFYTRTEAQYYLMRISYYEENDIQGSMQLAGYLHKTFPGNAYFHRFYTRLLYQSGNYGEATKECISILNRIDSAQAGYEYNSGRYASFFLGHMNEIHRNFEEAKKYFKLAMEYGEAADATDMGYYIYAVLHLGRIAEKEEDTEAAKAYYKQVRKITGRSHSANKEAKMKLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C4</accession>
    <name>A0A654E4C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein (Por secretion system target) (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024880892" evidence="1">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="21815" checksum="F10A5C447D017DCE" modified="2020-04-22" version="1">MKKLTMSAAVLLTVMSVAFAAGDGTNENRARVIASKSDIFKVLYVNSESSVVKIRLRDHEGKLIHTDRVKNEGGFMKPYDLSKLENGTYYLELTDQYGVFSEKIELLPEKESSTLSVKALENKKYELSVEQNEKLPLLLTIYNSNEEVLYKERYQDMKNFSRVYDLSQFDSQNFVFELTDHNSTRIVSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E6</accession>
    <name>A0A654E4E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013423">
        <property type="entry name" value="CHP02594"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02594">
        <property type="entry name" value="TIGR02594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="23636" checksum="19865FEA591D6C7F" modified="2020-04-22" version="1">MSELLKIATSQLGQKEISGPEDNPTIVNYAKEIGLSWINDDETPWCSVFVGWCALKAGLSYSKSALARSWLHIGTPVNVPEPGDVVVFWRESLLGTSGHVGFFMGYSQDLKRIYCLGGNQGNQVSISAQSAERLLGFRRLAKSTIISLPEGVLRKGDTGEKVVQLQDAMKAANYEVGTSDGVFGAKMDAAIKLLQANGGLKADGVYGPKTKNLLNTILNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G4</accession>
    <name>A0A654E4G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygen tolerance protein BatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025738">
        <property type="entry name" value="BatD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40940">
        <property type="entry name" value="PTHR40940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13584">
        <property type="entry name" value="BatD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024863916" evidence="2">
        <location>
            <begin position="24"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="482" mass="54907" checksum="48F97D36EE4FEF5C" modified="2020-04-22" version="1">MLKTREGWLGCLMVLIFSLPALAQEKQVEIGDTEIGMNQYFRITIKVENERLKGYTPFPEIEGFVKRGTSSSTSTSFINGRMTSSQSIIQNYQATREGSFQVNGFSMTINDEKIEVPGFTIKVGPPAKQQQRPSNDPFVDPFDVFKNRNSEPTEFIDVDADAFLALTTDKKEVYVGEGFTTTLAFYVAESNRADMRFYDLGKQITEIVKEIKPANCWEENFNIDNINGEPVTINNRAFTQYRVYQASFYPLNQENITFPTVGLKLIKYKVAKNPSFFGRNRQEDFETFYSKPKTVTVKSLPPHPLKEQVAVGDYRLAEKINSLDLKTGESFNYTFNILGEGNISAIEEPRLPETDIFDFYAPNVKQNVTRSGGEVKGTKSFNYYGIPNEPGTYQLGDYFKWIFFNPEKGVYDTLRSQQVLAVTGESRKNEYILSNDMGSFYDGIEFKENTLSSLDDSSWMRIFANVFILAMLALTVLVFIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J6</accession>
    <name>A0A654E4J6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yefM</name>
        <name evidence="4" type="ORF">MARINOS108_60115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="85" mass="9822" checksum="94D887C9B2641D94" modified="2020-04-22" version="1">MIAANYSEFRAGLKKYLDHVEEDNETLVIKRKSGKGTVLISLEEYNSIMETLHLLNSRKNADRLYESIEQMKSGKTHKPNPEQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J7</accession>
    <name>A0A654E4J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13564" checksum="AA12F50EA5D2BB4C" modified="2020-04-22" version="1">MKKVYYLSTCSTCTRIMKELGIGEEFVTQDIKKEPITEAQIGEMQALAGSYEVLFSRVAMKYKAWGLKEKNLMEEDYKRYILEEYTFLKRPVFIIDDQIFIGNSKKNVELVKDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L0</accession>
    <name>A0A654E4L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="426" mass="48843" checksum="FD5F46FFB0360778" modified="2020-04-22" version="1">MAYKTIILFLLSIFFQNQCFSQQDTSYLLGDLQKKVNLIVINAIQQRAFPGCVVYASHRGNPILLKSYGYKTYDSLDAVYTSDLFDMASVTKVMASTLALMKLYEDGLIDLDEPLRNYVDGLGWRKISKVTLRQCLAHQAGLQSWIKFYEEIRRNNGRYKGHTISDSRSEDHPYKVAEGMFLHKEFYKRIKKYIKAAPVNREPQYVYSGLFFYLVPEMVQRLTRRPFEVYLQEVFYQPMGLSALTFNPAEKFTLDRIVPTEIDSFFRYEPIHGRVHDEGAILMKGISGNAGLFGTAEDVASLWQMWLNNGSLNGVQYLKPSTIDVFTSYQYANKGNRRGLGFDKPLLEYDSLISSVAKSASFESYGHTGYTGTLVWADPANDLLFVFLSNRVYPTRESKAIYQLNVRPDIHQALYDYLAAIIENCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N8</accession>
    <name>A0A654E4N8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glpD</name>
        <name evidence="9" type="ORF">MARINOS108_60155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="404"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="548" mass="61723" checksum="593C2293C1116D15" modified="2020-04-22" version="1">MNAFNANDRGDLVKVLGDTHYDLIIIGGGITGAGIALDAASRGLKTALFEKNDFASGTSSKSTKLIHGGLRYLKQFEVALVREVGQERAVVHHLAPHLVKAEKMLLPLITDGTYGKILTSVGLMVYDVLAGVEKVDQRKMLTKEETLEMEPLLGPDVLEGGGVYAEYRTDDARLTIEILKTATRMGADIINYGEVTDFVYHAGKITGVHWRDNLTDTSYTSSCDYTVSAAGPWVDEIRAKNKSLHGKHLHPTKGVHIVVPHEKFPVHQSVYFDVPDGRMIFAIPRDRVTYIGTTDTDYHGDINDVRTEKVDVDYLINGVRHIFPEIKLNIKDVESSWAGLRPLIEEEGKSASQLSRKDEIFESETGLLSIAGGKLTGYRKMAERIVDRLSKKIREDKDKKLSDCVTDKIYLSGGVFKDGNDVHRYQKEVEQQVVSFGLDPYYAEYLVSNYGRQTGDIFKLFRQRQETDPEIRLALSELVFTIENEAVHSLLDFFERRTGRLYFNIKTIPKLIEPVFQHLTSTFGWSEARQQKEKDWLHLGLEVASHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S9</accession>
    <name>A0A654E4S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rpsL</name>
        <name evidence="8" type="ORF">MARINOS108_120502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14085" checksum="523639AD2C05FEEC" modified="2020-04-22" version="1">MPTIQQLVRKGRKKLTSKSKSPALDSCPQRRGVCTRVYTTTPKKPNSAMRKVARVRLTNGKEVNAYIPGEGHNLQEHSIVLIRGGRVKDLPGVRYHIIRGALDTAGVNGRTQRRSKYGAKRPKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T7</accession>
    <name>A0A654E4T7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DctM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_90009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="431" mass="45243" checksum="6F097BA22626C61F" modified="2020-04-22" version="1">MAITEILLLVASFLLLLALGVPIAVSIGLSTALTLMVSIPAMPALTTIAQRMATGLDSFALLAIPFFILSGQLMNRGGIARRLVDFAKVLVGSLPGGLAFVNIIACMFFGAISGSAAAAASAIGGFMTPRMEKEGYDKGFGAAVNLTSATIGLVIPPSNILIVYSLASGGVSIAALFLAGYVPGVILGVGLMMVSGAIAFKRKYKTGEWVGFKVGARKLLDAVPSLFLLVIVIGGIVAGFFTATEASAIAVLYTIVLTLIYKELKVKELPSVLLDTVKTTAIIMLLIGTSMGMSWVMAYENIPQEVSNFLVTLSDNPIVILLIINLILLFVGVFMDMTPAVLIFTPIFLPVVTALGMDPIHFGIVMVLNLCIGLCTPPVGSVLFVGCSVAGVSLQKVLKPLIPLFAVMILVLMLVTYIPELSLWLPGIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y4</accession>
    <name>A0A654E4Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="286" mass="32745" checksum="68FA6428B5AAE94C" modified="2020-04-22" version="1">MEDLIVFFENVPTWFRSLILIGGIVIFWVFEGVLPLFSFQYKKIRHAGLNLFFTFTTAIIGFGLAGVLLMASDYVTTHQIGLLYLIEMPLWLQVVAGILLLDMIGAYFIHWTEHKVKWMWKFHLVHHSDTTVDVTTGLRHHPGETVFRIAFTILAVMVVGAPMGIVMLYQSLSVLFAHITHANINMPARVDKLLSFVFVTPNMHKVHHHFTQPLTDTNYGNIFSFWDRIFGTYASVEDTRSLKYGIDTHMKPEENDRLGNLLGIPFQAYRTPSGKFSDPNLKEQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y8</accession>
    <name>A0A654E4Y8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">miaB</name>
        <name evidence="13" type="ORF">MARINOS108_11043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="176"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="424"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="487" mass="55726" checksum="3F5E80421F4556A4" modified="2020-04-22" version="1">MTQLIEDLEILDQSNDVQEEHCEVKVSKESNNQTAKKLYIESYGCQMNFSDSEIVTSILQKEGFDTTASFEAADVILLNTCSIREKAEQTIRKRLTQFNKIKLERPEITIGVLGCMAERLKSNLLEEEKIVDLVVGPDAYRDLPNLVRQAEEGQKGVNTFLSREETYADISPVRLNSNGVTAFISIMRGCDNMCSFCVVPFTRGRERSRDPHSIISEAQDLFSKGYREVTLLGQNVDSYKWSPEENNKARLEKQEVNQVVNFANLLEMVAQVHPELRVRFSTSHPKDITDEVLHTMKRYENICKYIHLPAQSGNSRVLELMNRTYDREWYINRVDAIREILGDDCGISSDMITGFCTETEAEHQDSLSLMEYVQYDFSYMFFYSERPGTLAAKKYKDDIPLEVKKRRLQEVIDTQRGLSLARNQRDIGKTFMVLVEGFSKRSNDDLQGRNTANKVVIFKNNGAKKGEYVQVKVYDCTAATLFGEVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E512</accession>
    <name>A0A654E512_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3 7">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">leuA</name>
        <name evidence="9" type="ORF">MARINOS108_20906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="506" mass="55718" checksum="0D6E53F2587541A7" modified="2020-04-22" version="1">MSDKVYVFDTTLRDGEQVPGCQLSTPEKIEVAKELEILGVDIIEAGFPISSPMDFNSVIEISKAVSDPIICALTRSVEKDIDFAADALKYAKRKRIHTGIGSSDYHIKYKFKSDREKILERAVAATKYAKKYVEDVEFYCEDAGRTDNEYLARMVEAVIKAGATVVNIPDTTGYCLPEEYGAKIKFLKENVKGIDNAIISCHCHNDLGLATANTMAGVLNGARQVEVTINGIGERAGNTSLEEVAMILKTHKDVDLHTNIDSKHIYALSLLVSKMMRMPVQPNKAIVGRNAFAHSSGIHQDGVIKHRENYEILDPEDVGIPQSSIILTARSGKAALKYHLDRLGYSLEEARVEEVYDDFLKMADAKKDVTDDDLIILIEGSLPEGGIKLKNVQIICGESVFPSATVELEVNKEIIHASATGTGSIDAAFRAVDEILGEVFDMDEFLVQSMGNRNDDGKVHLRVKYQDQHYMGFGVHKDIIIASVKAYVDAINKITSVKSKVLKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E526</accession>
    <name>A0A654E526_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024885448" evidence="1">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="26899" checksum="E6450549B9B1781D" modified="2020-04-22" version="1">MKRYLLSPVLFVCIVTGGAAQATLGGNDASGLDMNTEIGGMVSVVDFTNYDPVGNVYLFEDWKSGKLTLKNGVQTGNLILRVNLLNNNVDVKDKNRVRTFSIEKIQFVDISVLSDSAIRYINPNEYRYSDQTPIIGLLRDVSRGETWSLVERHFIKIYEANYVKALDAGSKQDRYESAKEYYFLRDGIVYPASGNRKKFASGLGLSESEQEALVDYVKSEGLSTKNVDHLTLILRFLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E559</accession>
    <name>A0A654E559_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_90106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="392"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="870" mass="97372" checksum="3A61F6D647CC1B1E" modified="2020-04-22" version="1">MTSANPPKLPFRILRWFCKPWYAEVIEGDLLELYHRQVATHPTKARLAAYMNVIRFFRWRYIKDLEDFQPNTPFGMFKTYFKVTMRSMGKNKVQTTLNILGLSMAIAACLLILIHIKYQFAFDKHLPQLENIYRVTLNERGGNTPALLVKQMQADYPEVLNGTRISGPLESVISLQGRYIRQGGGIYADSTFFDLFPATFLAGRSGQVLSGPRDVVLTKRVSDKLFPNGEVVGEEINVDGDDYRITAVIENPPATSSIPYEFILSMPRESWVTNGWWTGNNFYSYLLVDPNANIDQLEGKFPDFVQRYIGPEILGFYDAYATLEDYFAEGHQYSFGLVPMKDIHLHHPRLSLGTGADYQSILTFGGVAVFILLIACINYVNMATARSSLRAKEIGMRKVMGSVKSLIAQQFLLESFVITFIAMVAGLVLALVCLPYFNQVSLGSYGILDIVNLQNALWFFLILIATSLLSGIYPALYLASFRPIAALKGETVKGGGSRMRSGLVIFQFSISLLLMVGTYIVYQQISLMSNRKLGLATEQTYVIRDARKIAGDFGAFKNQLLSQATISQVGLANGYPSGGMADWNYTSVDEDQIQLSPNNIFVSSEILEVWGLKLQSGRFFSANLGTDTMNIVVNETLVKTLGWEEPLGKMLGRSEGHFKIIGVVEDFALGSAKSGNAPVVFRYMNDGVFDIFGGDYLMVKIDGNLRDALEHIEATWDRFLPNYPLDGRFMDDSFQALYDGERRFGLLFSGFSVLAIVIASIGLFTLSAFVLERKRKEIAIRKVLGARVGQIFVRIIAYFGRLIIASTFIAVPVAFYLGHDWLDNYEERIDLSSMIFVIPLALLALISLVTVALQTYRMAANNPLDSLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5E0</accession>
    <name>A0A654E5E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scpB</name>
        <name evidence="4" type="ORF">MARINOS108_140129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21092" checksum="5EBD0B9E89F1DDE9" modified="2020-04-22" version="1">MDYLANHIEALVFCSPKPITEDEIQSCLKEMFEADVPMEDISGGIAKLSEKYEDEQFSFGLVQSGGGYQFLTKPAYQASISILLKQQSKRRLSNSAMETLAIIAYKQPVTKTEIEQIRGVNCDYAVNKLLEKELIEIKGKAETIGRPMLYGTNNKFMDYFGINSLRDLPTPKDFVQEENTIGKEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F5</accession>
    <name>A0A654E5F5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">argD</name>
        <name evidence="4" type="ORF">MARINOS108_90087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="397" mass="43014" checksum="EF92A18DD104AFD2" modified="2020-04-22" version="1">MSYSTKELHELDKTYYLPTFKRYPLAFKKGSGSRLWDMEGKEYIDALAGIAVNNVGHAHPKVADAIGRQAHELIHISNFYLSEPQVMLTKKLAELSGLQRVFLGNSGAEAAEGAIKIARKYASKNGRRGTIIAMKNAFHGRTLATVAATGKEAMMNGFAPIPAGFLHAPFNDLEAIKEMVTEEVGGIMLEPIQGEGGINLVDPSFLKALRAYCDEQNLVLIFDEIQSGMGRTGKMFAFEHFGVTPDVMTLAKALGGGMPIGAVLASEKVGSAIDWGDHGTTFGGNPLACAAALATIETMEEEGMLKQATEKGAWLKAEVERVRSEYPEIKEIRGYGLMIGIELTIESKPVVTTMMEHGVLANATAGNVIRLVPPLNIPMEDLKTVFEVMLKSIKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Q8</accession>
    <name>A0A654E5Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="13815" checksum="CCB95A1D53308542" modified="2020-04-22" version="1">MSVLQKVIESTFFSLLSVITCRRSSTLSAAASVISTSSMRDFGFILVIAPSMTRSNSLAGSSSSGLTILTGISLMNIFTRSLALRTNKTHKYWGIKAPSNIFKKLIDKACLYNNTTIKSQKKSLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E603</accession>
    <name>A0A654E603_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="2">
        <location>
            <begin position="212"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="2">
        <location>
            <begin position="352"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="2">
        <location>
            <begin position="504"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="648" mass="68542" checksum="4E848241F4B47AC4" modified="2020-04-22" version="1">MKNFKLLIGCLTVMLLSIVITGCEDEMMAEVKVGSISAEAVFQGSPVSLTGEGFDQVQFVFVGNIQASFTLDGNTITFTVPDEAPVGETTITLAMPRNVRATYVFEVVLKPSPVITSFDAYVPVGGDLVIKGSSLNNNTSVTVDGISATVVSAGDSELVVTVPSGVDETSAIEFEITTTYGVAKPTTAFYARESVIPNSDLEAEGDGVPFAGWELLNAGDGAITAITSGYGGSRSMRVVPAAGNPWDRQVASTAVPLNFGDVYTVVLWAKGETAGAQMRVSVSQYDGNGADYFYGETVEMSTNWEQYTWTFTVTNDLPTHRVVLDMGMGAVPFAIDQIGLVPGSIGASGPVELLANSSFETDLTGWTALNGAAEVTSAEAYCGSQSMTATGAGGNPWDVQIASDAMELEVGTDYEIGFWAKAEGPDGVFRLSMSQFASGQSDDFFYSPDLTIPEEWTYFSFVTTAQATSTGNHRLLFDMGASTQTFFVDGVSVKEYEVSSSSEYSNGGFEDGLTGWTALNGAAEASTDAHSGSGSMTATGAGGNPWDTQIASDAVALTVGNQYKISFWAKAAGPDGVFRISMSQYDGNGADFFYSRDLEIPEDWSYFAFVTTAQATASGDHRLLFDMGATTQTFFIDDVSVVEHDACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E626</accession>
    <name>A0A654E626_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9336" checksum="563BE57C0EA33A06" modified="2020-04-22" version="1">MISTIEIEELIKAMISKETGTRLSDINSQSTFHQLGLDSVNSLFLLGDLEETLNLDIDPLSLYDNPTIESFSAYINELQNDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7P2</accession>
    <name>A0A654E7P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="4883" checksum="8F0FF867FE81E6DD" modified="2020-04-22" version="1">MGRNKIIPNTAIPVKAPIDFLDSISFLLKFNQTYAIQAFKNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E867</accession>
    <name>A0A654E867_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="3">
        <location>
            <begin position="263"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="350" mass="40911" checksum="6C5E7E0A6D2F0283" modified="2020-04-22" version="1">MRLKEVSIHIISWLAFSLIVFYWQTNMFEDSDALIQTARMISVGMALFYLNLYVLLPRFFESNQFIKYSLSVLVILAVAYFLFFLTNDLSPRPEMRIPRGMKEGVEMRDRPPMPPRNMSRMVIFTIINGIPMLFFSTIIWLSDENRKRKQREAALINENLESEMRFLKSQINPHFLFNALNNIYSLSLTQSEKAPQLIIKLSEMLRHVVYHNTSPVKLENEIGYIQNFIDFQNLKIGEPIDVSFHHEEADKHLIIEPMLLIPFVENAFKHSNIENDPKGFIHIAITTQHNKVIFDIRNSIPTMQHTKDKTSGIGIENVTKRLAMGYPGKFQFLKEIEQNVFHVNLQIDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E887</accession>
    <name>A0A654E887_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="14346" checksum="6FA0E1E37E1168E6" modified="2020-04-22" version="1">MEIAENEMLFIYDSNDLQDREALAYAKSLKHYHVKALDVRKHTFTEWQLEEILERLEMEPDDLINQRSAVYLEEYVGVELSREDALKAIRKHTDLIRTPVAIYHDTARLIGSSYEFIKKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAS7</accession>
    <name>A0A654EAS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein with beta-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_130007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815949" evidence="1">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="30629" checksum="5B16BDC2310E9324" modified="2020-04-22" version="1">MIKYFIVVLYLLCWTGANAQYWFGPKVGGHRTDFIYQESTYKSDSFDVSTDYGLQGGVMMIYQASEKYAVMAELIYERINRKVTEKEGSDIEVYSKSVYNYLSVPFSLRWDFGREPTYYYISGGPKLSYWLGGTGEIYLDEFNEARTLDGPLPYDFEFKSKNGGETNHRAVPQANRFQYGLQVGAGVYFDVTTGGRVLVDLRHSFGHSNMGFNGNPDFSFETYQENFRYRNYTLSLSVAYLFEYDVQLQRKGMSTIRESNKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB18</accession>
    <name>A0A654EB18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024852755" evidence="1">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="513" mass="52048" checksum="5FE9D68C14C09D14" modified="2020-04-22" version="1">MKKLLAIAFMLSGLMFITSCTEDTVDPDNGVTISGLTAAVSIENLGTYGPVTVTFEGADGLASVSLTKDGAAYGDTTFTGAPTTASLEFGYTATEADEDANIVFVFTATDADGDVESSTVVISVGEATPPRETIVLSGVIDEDMTLTPDGFYELAGRVIVTGGATLTIEPGTIIKGRLGEGSNASVLMIARDGMIDAEGTAEKPIIFTSVNDNIALGALSGTNLTATDNQLWGGVVILGNAPISVEAGTSAQIEGVPASEPLGQYGGDNATHSSGTFKYVSLRHGGTTIDPVAGNDINGLTLGGVGSGTVISNIEVFANYDDGIEFFGGSVNVTNVLVYTVGDDGLDVDQAYSGTIDNFLVYTSTAASSDEGLEIDGPEGSENATGKFNIKNGTITSVDGGGSGADFKSKAQGSVTNVKWANFTGGSTVKIRASFNADCTVKTDAMSHLTAGDLSFTTVEFAAIKVYSDQDCATELAAAQASAEASVTIGTATGVSDATVFASWTAAAQAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECX3</accession>
    <name>A0A654ECX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxaloacetate decarboxylase gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">oadG</name>
        <name evidence="2" type="ORF">MARINOS108_20507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="87" mass="9357" checksum="B8005ED85130E2D7" modified="2020-04-22" version="1">MVTIQFRLMMNSDLSTAFSLLGIGMITVFVVLLLVVITGNLLIRVVNRLAPAPADDSLEKAQVAAITAAVNIFTEGKGQVTRIEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF65</accession>
    <name>A0A654EF65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tripartite ATP-independent transporter DctM subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_60103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006066">
        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="434" mass="46650" checksum="2E4E8E528B8E80F8" modified="2020-04-22" version="1">MIEYLPIILFATIFVLILFGFPVAFTLGGLSVLVGIVVFDVDFFYLLALRVYGTMQNFVLLAVPLFVFMGIMLEKSGIAERLLETMALLFGRFRGGLAISVVIVGAMLAASTGIVGATVVTMGLISLPTMLKRGYGPRLSTGVIASSGTLGQIIPPSVVLVLLGSVLNVPVGDLFLAAVIPGVGLVVCYVLYIVIYAQVFPGRAPAMPKAEVSAFRERGFSGELVKSFVFPFLLILAVLGSIFAGIASPTEAAGVGAFGAILLTLSQRKLTMPVLKEVMRETTLLTSMVFMILVGATAFSLVFRGLEGDKLFLGLIERADMSPYAFLFLVMVLVFVAGFFIDFIEIVFIIVPVVAPLFVAMGIDLIWIGILLAVNLQTSFLTPPFGFALFYLKGVAPPEVKTSHLYQGIIPFVLIQIAFLILLVIFPEMTSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFB3</accession>
    <name>A0A654EFB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS family solute:Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_60153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="565" mass="62032" checksum="F5E6B04A12C03DB7" modified="2020-04-22" version="1">MENVALSFVDIAIIVVYIFGIIWYGISKGKQQTSEEYFLAGRNMTWPIVGISLFAANIGSNTLIGLTSDAFQTNTAVYNYEWMAAVVLVFFSIFFLPFYLRSKVYTMPEFLERRYDSRSRYYFSFITIVGNVIIDTSSGLYAGNLILKIIFPEISSTFIIIGLALAAAAYTIPGGLSSVVHTEVIQAILLVVGSMILTYFCITEVGGWSGLMSGLDALNSSGYISKPADEVFDMAGPVDDAYMPWTGLLFGVPLLGFYFWANNQFMVQRVLSAKDLNHGRWGALFAGLLKIPVIFIMIFPGVIAIVLFSDLDISGLNYLITNEAGEQVICQNLEDCPNMTYPVMLYQLLPTGLLGLVIAGLLAAMSSSISATLNSASTLITMDFVNKLNPNLSSKQLVRVGQIATVVLVLLAAFWTQYIEQISDSLWEYLQLVLGFIAPPVVAVFLVGLFWKRGNGNGAFAALLAGLAISVLIILSSVYELFPSLNAIHFLHKAPLLMLACMLVHVIVSLLTPAPSDEVVNTLTWNVGLYRAETKELAGLPWYKNYRVLAVILLIITAFVVGSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSQ4</accession>
    <name>A0A654DSQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="7872" checksum="51E8EC8C6D024507" modified="2020-04-22" version="1">MKIIRFIILIGMATSCQTEEKSRINVMTSDIDHFWTAYDLIIKEPDSLKRIQLIDSLYIQQGSIGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTZ0</accession>
    <name>A0A654DTZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="16"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="312"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="45976" checksum="69EB320A1FD9E12F" modified="2020-04-22" version="1">MIKFLLKGILGDKTRSVLPVMIITIGVALTILLSGYMRGVMGDMIDQNARFETGHVKVMSRAYAENKDQLPNDLALLGVGELNESLAKQFPEMQWVNRIKFGGLIDVPDDLGGSKGQGPAAGTAVALFSTESGEDVRMNISSSIVKGSMPSHSGETLVGHDFAEKLHIQIGDEVTYMGTTMNGSMAFENFVVSGTVKFGTTALDRGAIIVDITDARRMLDMEDGAGEVLGYFKSGAYDDSRAIAMSETFNGQYADDSDEFAPEMFPLRTQNNLSSFLDYVDSFSTLFVVIFVFAMSIVLWNTGLLGGLRRYQEFGIRLALGEEKGHIYRTLIYEAILIGAIGSVFGTIVGLGGVYYLQVVGIDITGMLDDSTMMMPSVLRASFTSDLLYIGFIPGLVAMVLGNALSGIGIYRRETATLFKELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUK3</accession>
    <name>A0A654DUK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="118" mass="12972" checksum="E0FDEE1FE2CAB67E" modified="2020-04-22" version="1">MDHHLQSVLMPIAVLGTLSVGIVLIIKTLTEYFLRKKMVEKGLVGDDAGELLRKQVENKYAALKWGLIILFGGLGLMIIEMIPFDSSSTLPYGVLATSLSLGFLLYFGLVQKMNKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS0</accession>
    <name>A0A654DUS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein Qin prophage</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspB</name>
        <name evidence="4" type="ORF">MARINOS108_10758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7222" checksum="166D5B2B461D9C34" modified="2020-04-22" version="1">MQEGTVKFFNNSKGFGFIKPNDSSEDIFVHESGLVDDIRENDKVKFDVEKGRKGMNAVNVELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV40</accession>
    <name>A0A654DV40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="29077" checksum="A5EBB2422EC30E9E" modified="2020-04-22" version="1">MLKIAFLLELFFITDHFLQESAELHITGVYQGKTLFIQNPYDRESKLFCVTAIYVNGSKLGLNYKVSALKLDFDGIDKFSPLSIKVQHAPGCKPIILNPDAIHFHSTFSFGEVGFADTALVWKTSGEKSGSVFTLEKYQFGIWIEGDTIPAKGEFGGAEYSYSPLLEEGANKLRIKYITPKGDYLLSREVDFHFYPEPVTFKPYNATNTLYLSRAASYEVFDAGGDLVLSGQGTTADISSLPSGDYVIYFDSKDPGVFRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVH8</accession>
    <name>A0A654DVH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031709">
        <property type="entry name" value="PutAbiC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16872">
        <property type="entry name" value="putAbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="32155" checksum="455C828693356193" modified="2020-04-22" version="1">MKYYHKLFLALALCFLIGSIIVPFLNINDLPIDSVKISVSGEMISLAGTMVLFAALIYQIKEYRLQLEELKKSVEAQVISATELENQRKILLEQRSLSLITSIITDFHNFNSRQDNLKLIKEEVQYLSGLFVYSWKNLSKSSVDERSEIFPKRVCQLIGKVLPNRPEYVILESYVQYAFNVLSVIDENKYLVSSNYKALFLCQLDRHELLLLYFFTFDSFDIPGMPYYDNLQWKNSITTELLRSMKKEDTHSTDYSQINLNKAVSEFQKLQYQSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ1</accession>
    <name>A0A654DVJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="57322" checksum="100A29A83F30D9DA" modified="2020-04-22" version="1">MKTKLKKFTAFAAEILPHEADYLTSIQQFEDAEKEEILKRVSANAHGQQNKMPFNTKIDKRKYSSLMDWIQKRLDNIDVDSYFEWVNDMDRKVITDAISHEEEKVLLKRIKNYEHPVHNFMKFYELVQNYRHYLLIRLRHKDYQEVNDFIEKYKADYEYSKEVNQKLHQATVDIIEQFNLKKGDSKQWEDWLLSLFRNENLDGFNRYMAVVRLTFLYFNSREFEKLKEVYDRLDELLARGIFYTRRILYNYYANRLMLHSKFDVLQQAEEYGYLSIRQKNADHVQYLSNFSSILIRRGKIEEALNLLKESFSEVQKSSNFYHKIGFISFYIKCLNLNNQPQRGEMLADSFLRIYKDEILKERWYSFFTAYIQGLIKQEKYDKILQVFRRYNLIAKDEEDSNKSIYLPTIRWYYEIALLKVGRLEAKELVESIVDFSQEHVANPHKSFILNQVLSELESYIPRTVIMARTRLYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL7</accession>
    <name>A0A654DVL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024895737" evidence="1">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="24877" checksum="278981AA639BE7D7" modified="2020-04-22" version="1">MPFTVKEKSINMKSLLTLSLFCILIAACTHDTVSPTLEADQELASNYTHMEVGNFWVYDWYEIDPEGNSAFYSRDTLLVTGSVKVDGHTAIELTGQRLGLDFDVILFDSAQSVYTYPDRFLYFTLDSTTHHGVIGPSDSPLFTTFYYLEKAPLEVTVPAGTFECLNFQGKYVPQNKNYPYSTRYNDNLFAYKIGMVKMTTSYANSPNTLEGRLITYGMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVN5</accession>
    <name>A0A654DVN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024946573" evidence="1">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="21345" checksum="C7444D72564C4C56" modified="2020-04-22" version="1">MIKTRKTMKRVTLLPLFLALLSSVAPVIAQTNLELATLAAPEAYRANATVYGYNADGTFVLLREGSNHLVCIGDDPSKEGFSVVAYHKDLDPFMARGRELKSMGKSFDEIFATREAEAQAGKLVIPDKSTLTVYQADLDDNGSPINPYLRYVVYIPFATAEETGLPTGPMSDGGPWIMDPGTHRAHIMITPPRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT6</accession>
    <name>A0A654DVT6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">folE</name>
        <name evidence="8" type="ORF">MARINOS108_11192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="7">
        <location>
            <begin position="50"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="26857" checksum="DEDB47E219A55602" modified="2020-04-22" version="1">MKQKETSLNTPHNMNHLDDDFAEDHAGTSDSTPLRSDAFEMDDDLKMELIAKHFKEIMQILGLDLTDDSLQGSPKRVAKMYVQEVFSGLNPKNKPKVRLFENKYKYDQMLVEKDITFYSHCEHHFVPIYGKAHVAYFSSGKVIGLSKINRIVQYYAKRPQVQERLTMQIANELKDILMTDDVAVVLDATHMCVSSRGVSDTNSMTGTAFFDGKFRDQNIKTEFLNYINAKTDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG9</accession>
    <name>A0A654DWG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="244" mass="28042" checksum="B8AE1031536FFD82" modified="2020-04-22" version="1">MPDITIIQLATPNIDRYALFSAASARSYALAHGYHLQIQRSKTITDLHINWTKIDILKTVLANSPQGPDSYVILLDADTVIMRPDRTIDYFVGKYGRPNTSIYMAADTPFSLSRKKKPNAGFVIVRNDETGRKIIARWIDAAYNDGKQFNDIHPRNQLVYWNCVEPEYQEQQVVLPKRYFHKPLWWVPKPMKKNRFLYHITSSNVDSRTAQMQGFYEEACGNRKNLEETKALLDGGKEGLLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT1</accession>
    <name>A0A654DWT1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4915 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017481">
        <property type="entry name" value="CHP03032"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16261">
        <property type="entry name" value="DUF4915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03032">
        <property type="entry name" value="TIGR03032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4915" evidence="1">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="359" mass="40100" checksum="03070F95D48AC9AA" modified="2020-04-22" version="1">MEESPNVPPPFSYRFSPNVPELLQGLKCSLAISTYQTGKVIIFSPKDQDSLVQLPRNFNRPMGMAISGNKWAIATRDQLLVTSNAPGLAANYKPNPNTYDALYVPRVSYNTGTLDIHDLSWAKDKLIAVNTLFCCLMVNSDEFSFKPVWKPHFVSELMPEDRCHLNGMALENEQPKYVTALGATNTPRGWKEGMLTSGILMDVESNEIIMNDLPVPHSPRLYPDGLFMLLSATGEVVKVDPQTGKYDVLTKLNGFLRGMDRVGDYLFVAMSRLRQGSSLFKEAPIAKESVHCGVSIIYIPSGQQVGFIVYNNTVEELFEVKALRNTLRPNVLNMDKGVHQQTIVTSDQVFWTEADDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW1</accession>
    <name>A0A654DWW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gatB</name>
        <name evidence="12" type="ORF">MARINOS108_10053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="335"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD10441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="488" mass="54362" checksum="95EB47ED8FFF196C" modified="2020-04-22" version="1">MISEEVKAKYKLVVGLEVHAQLNTETKIFSSDGNSFGDAPNTNVSTISLGHPGVMPKLNIKAVEYAIKMGLACKSKISEYQFFDRKNYFYPDLPKGYQITQDKTPICIGGSVPVVYDGNQHSEVVLNRIHLEEDAGKSIHLEGETDTLIDLNRAGVPLIEIVTEPVIKTPEEAGAFLTEVRKLVRYLGICDGNMEEGSVRCDANVSVMRTTDTQLGKKVEVKNMNSIKNVVRAIYHEMDRQIALLEAGEEIISETRTFDANTGDSSGMRTKEELNDYRYFPEPDLSPLRVTSDWLEKIRAEMPLLPSDFKSKFEKEYGLSESDALVLTDQKEMAYFFEELCQQTNNFKGAANWVMGPFKSYLNETGNTIESSVIRVSHLSGIIQLIDEGVVSFSAANQQLFPYLVANPGATPLEAAQTLNIFQESDTASIQPVIDQVLIDSPQKVAEYRKGKKGLIGMFMGEVMKKTNGKVDPKLANRLLRESLETIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ2</accession>
    <name>A0A654DWZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FA_desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="362" mass="41882" checksum="84D7BB346C2BCEE6" modified="2020-04-22" version="1">MVRYNQIENAEFFAVLRVRIQHYFKSNELSIYAEDVAYAKAIVLIGAYALTYYTLLHTSAFDLYLILCVVLGMLKIFIALNIAHDAAHRAFFRNRKLNDLMLFTFDALGANGYMWKLRHVHSHHAFTNVPDHDADIKQSALVRIFPNSPLSGLHSYQHLYMPVLYGFYSLHWLLFRDFKDFINTPPNNHLTYHRKVELIRLILGKLIYFTMMILVPYQLLALEFYQVILGFMVMQMSASYTVAIALASAHVGEHAEFPEPDRTGQLPYSFLMHQLITTTDFATDSKLLTHLYGGFNHHVIHHLFPNICHIHYPPLTKILKNTCKEYGIGYNENKTLIDAINAHLQLLKSRSKNNLTVAMPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX14</accession>
    <name>A0A654DX14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0347">Helicase</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="253"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="470" mass="52909" checksum="F0B99226ED923C24" modified="2020-04-22" version="1">MGYKHDSVFPTSKPHIPAINTPSLPSQNFTREHITMGTLKNQQDILDKLKIEKLNPMQEEARQAIHSTQNVVLLSPTGTGKTLAFLLPILSELESDCEEVQVLILVPSRELALQIEQVLREMGTGHKVNAIYGGRAGSKDKLDLKHRPAILIGTPGRIADRFRRDNMPTEFIKTLVLDEFDKSLEVGFEKEMREILSSLRKVKKRILTSATHGVEIPGFVELRNPTYIDYLGEKTSQLKLKKVSSPDKDKLQTLTALLGHIGNQPGIIFCNYKETIQYVSDHLTKNRVSHGTFYGGMEQKDRERVLIKFRNGTHQLIIATDLAARGLDVSELKFIIHYQLPPREEEFTHRNGRTARMNSEGTAYLIQWEKEPLPDFIKGAREEKLSKANLPGPSIWSTLFISGGRKDKISKGDIAGIFFKQANLSSEEVGTIEIKQDCAFVAIHSAKASEVVKTLDNTRIKKKKVRISVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX91</accession>
    <name>A0A654DX91_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5038" checksum="6B8258FF2BCA5537" modified="2020-04-22" version="1">MFGLFLGIVGVKMIHTCPGRARLGCPALLYDPIFLNQSELIGFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH7</accession>
    <name>A0A654DXH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="4960" checksum="25142A442E857DD1" modified="2020-04-22" version="1">MYNISKTFPAHSKAPNQNSVGKLSCAKHTSHYVYNPIFQFSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR8</accession>
    <name>A0A654DXR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="439"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="517" mass="57415" checksum="E194A2A74CC646EC" modified="2020-04-22" version="1">MRRRSFLRHVSHSLAVPGVLGAMGFRMPGPNSLTSLLRMAVDTDRVLVMIFLEGGNDGLNTVIPLDQLSALNKVRPHVIMPDNKLLNLSDADVAFHPSFDGLKSLYDENRFQVIQNVGYPQQNYSHFRSTDIWMSASDSNELVNSGWTGRFLSDSYPGYPESFPNDDMTDPLSIEIGYGSSLLFQGPQSSMSMVISDPDFFYDLIENEEREVPDTPAGEKLKYVRLIAKQSQQYGQVVKAAAAKVKSQATYPQTYIAQQLKIVSQLIAGGLRTPLYLVRMGGFDTHDAQVEGSDHTQGEHASLLKDLNDGIMAFMKDLEMQGTDDKVVGQTFSEFGRRIVSNASLGTDHGAAAPMFFFGNAVMGGVTGTNPSISSNAKYDDNLEWEFDFRQIYASVLEQWLGASSPQDVLFRDFETVSIIGEREKTLAAQPQEGRGLLVYPNPLNGRATIRVDAVTEAVAIDLIDISGKHIESIYRGNISQDQQISWETYRLPPGKYFVTVRGQKTRRVFPVMKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY07</accession>
    <name>A0A654DY07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-hydroxy-acid oxidizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="382" mass="42932" checksum="ADCB38DDCA10F320" modified="2020-04-22" version="1">MSYDSRYPAIDDLIRKAKRKIPRFAFEYLDGGCNEDVNLARNTKEIREVQLIPQYLTKHTKSEMKTELFGHVYDAPFGIAPVGLQGLMWPKAPEILAKAAHEHNIPFILSTVTTMDIERASELTDGKAWFQLYHPADNALRDDIIRRADAAGCSVLVLLCDVPTFGFRPRDIRNGLAMPPRMTLSNMLQIMGRPDWALRTLIHGQPNFTTMKPYMPKGLDMKQLGRYMDQTFSGRLNEEKIAPIRDMWKGKIVLKGVACEADAEKAVKLGLDGIIVSNHGGRQLDAGNSTIKPLKYIAEQYRDKLTVMMDSGIRSGPDIARSLASGADFTFLGRTFMYSVAALGSRGGDHAISLLKTQLQQVMEQVCCERIEDFPNFLDRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA4</accession>
    <name>A0A654DYA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IX secretion system PorP/SprF family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024961836" evidence="1">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="33918" checksum="793729C1A5E9C6F0" modified="2020-04-22" version="1">MKIFTFCSILLVSGFSLSAQDFLGSSSYFMNPFSLNTAYSAPGGDLFAAFQANKYTGSQSEKGAEYISFGTYYGLGRGLSSGLRMNSQSLGMINYQGLDVSLAYMAGITEDHYLSFSLAAGLLREKLESSDVKYSPYVDQDDPLLNSDNVYDHTQLTLGGGFVYNVYKFQLSYYMPYLVKGNESLKFDFNTLAKFTYTHYKSIVSVENYVMYRYFHDGSGFYDGGLLVGWSKTLWLNLAYRSTKSVNAGVAFENSGFKVGYSYNHPFGEFNELITGKHELTVTYSVEDLGRRRPYFFRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE2</accession>
    <name>A0A654DYE2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="49538" checksum="3FDCCFA47968D864" modified="2020-04-22" version="1">METTQSGKAKRIELFNLRSINMRVFHLTWLAFFLCFFGWFGIAPMLSIVRDDLGITTDQIVNTNMIAVASTVFMRLIIGWLCDRIGPRITYTWLLILGSIPVMMIGMAQNYEQFLIARMFIGAIGAAFVITQFHTSVMFAPNVVGTANATTAGWGNLGGGVTQQVMPVVFAGVLAYVGAEHLAWRYAMIGPGVLLFVMGFVYYRFTQDTPEGNYKDLPNINKKKSEAKDSIGTVLKDHRVWVLFLIYGACFGVELIVNSKAALYFTDYFDMDIKTAGLIAGLFGLMNLFARSLGGYFGDRFGKIGGLNGRVKWLFVALFMEGLALILFSRMDTIPLIIMSLIFFSLFVQMSEGATYSVVPFINKKALGMVSGIVGAGGNAGAVAGMLLFKKQLTGLEWTDSFYVLGFIVLGVSFSSFLVRFTKKAEVATPAANKEVTVEKHLQPELAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH1</accession>
    <name>A0A654DYH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_11741</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024926147" evidence="7">
        <location>
            <begin position="20"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="11">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="409"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="566"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="641"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="10">
        <location>
            <begin position="795"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD14054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109504" checksum="37E125F324B58012" modified="2020-04-22" version="1">MKNSAIYLLLMCISLTGYSQTQFETLNYLYSISGNYTVSGMHNDRKTGDDPDYHTNHINSLTGDYPGLWGGDFSYDSRMNSSSRWAMVYEAVEQWNAGALVNLMWHPCPPDQSEPCNWEGGVKSSLTSSQWNDLITNGTYLNNVWKQRMDDIAVYLQYLEDEGVEVLWRPLHEMNQGNFWWGGRPGPNGTRKLFEQMYDYMTYTKGLTNLIWTWDMQDLGQGWNDYKPASNTWQVLAMDIYGSGHSTSWYNYVKSVADGKPIAIGECWDLPTSSQLATQDEYVFFMGWDQNVWQQYNTNSEIQNVIWASNVLVRDEMPGWTGSGGSTDNQSPTAPTNLSSTATTTTTVSLTWSASSDNVGVTGYDIYNNGSWIASSSSASVNVTGLSPGTAYSFTAKAFDAAGNYSAASNVVNVSTQSGGGSLTNLSLNKSVTTSSGAGGYAVDGNTAETSRWSAEGFPQWLEVDLGDVYSISQTQVVAYQDRAYQFVIESKTSAGGSYTTIVNRSSNTTPGTVSSPITDSFGPVNARYVRITVSGASGYSGSWAALVEFSVFGGTSSGDNQSPTVPSNLTSTASTTTTVSLSWGGSSDNVGVTGYDIYNNGSWVASSSGTSVNVTGLSPGTAYSFTAKAFDAAGNYSAASNVVNVSTQSGGGSLTNLSLNKSVTTSSGAGGYAVDGNTAETSRWSAEGFPQWLEVDLGDVYSISQTQVVAYQDRAYQFVIESKTSAGGSYTTIVNRSSNTTPGTVSSPITDSFGPVNARYVRISVSGASGYSGSWAALVEFRVFGSNSGGNQPIVIEAEDYDSMSGVNTYSTSDTGGGSHLGAISSGDWMLYEDVNIPSSGNYTVSYRISSEGGGGTIQLDQGSGGTVHGSVNLPSTGSWSTWATVDQSVTLTAGVQDIRILAVSSGWNINWFSITPAGGSRVDGAEIEISEEITKYPYPNPFKESIVFPLNELGGSNLEIRIFDLSGSLIRVFSKSDFTNGKVFWDGKSMTGELVPLGVYHYQIDNKNHRINGKIIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM5</accession>
    <name>A0A654DYM5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">MARINOS108_10671</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="23378" checksum="FBB91E3C6BCFBD6D" modified="2020-04-22" version="1">MKQCLISPSMLAADFANIQRDVEMLNESEADYIHIDIMDGVFVPNISFGFPVTEAIARHAKKPLDFHLMISQVDPYLEACKNSGAKIITVHYEGAVHLHRTVATIKSMGIKAGVALNPHTPVSVLEDLLADLDLVLIMSVNPGFGGQKFIPHTFAKVEQLASMAANINPDLLIEVDGGVTSENAAALIQKGANMLVAGSFVFQSADPKQTIISLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN1</accession>
    <name>A0A654DYN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="292" mass="31803" checksum="BC3D8832526CB472" modified="2020-04-22" version="1">MINNQHQLKALSLCAILGFGLLFTGCQEDVTEPSAIIDADAATEARAIYSSREVYFTRSNGQVSSSTASSDFGNVSGWDAGATYISSNTLRITLAANVVGTSGGMESRIDVSDGTEYWLEYKVRFHSQFDWSRGGKVGWGFQVGDGVTGCRASDAQAGNGGSMRAMWYSPNSSDSRVYFQPYLYHQGMTSNCGESFGATYPSSGALSRGTWYTIGFYMKSNTGSSYNGTAEMKVNGSTVLRRDNIKWASSDSKRKVKGLYYSVFRGGSQSYWGSSSTGYIYFDDLKWARISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ4</accession>
    <name>A0A654DYQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15674" checksum="AA99E0E82168A916" modified="2020-04-22" version="1">MEFRTDVHVEAARIQNEIKNFLGLKSSDLVFEFASSEGKVKLDLITINPRHNQSFLFKTITGFDKTDALNKMLDYVKTHKEKESSYTIQWTTKGMNELQTSYFRAKNIYDAMDKLYYGRDMNNITVFSVVLNPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV9</accession>
    <name>A0A654DYV9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="44551" checksum="BE22D54692A256A2" modified="2020-04-22" version="1">MNKINDLGSRSDRNTVFSRELLAEADDEKLKMIVEEAARDLNTPIALVTLVMEHVQFFKAHYGLPQDLAAMRGTDRDISFCQFVVATGESFEVENALTDDRVPKELVEQYDIRAYMGMPVTINDTVVGSLCVLDTKPRKFTETERNDLRKLSMLVNGRLSALASRRNQSNAMLLEHAAFPALVELRGLLKPIRSGIDVGHATILELSTFLRIAERSLYGRTFSKEEMLKTLSRAKEALDKYQNGLYDITVSVDDAEDSIDALEHVFHSSTTTLLSEIAISGRELARHSTVQSGGVLLPEIEEDIFVSTPRPFGVSLLAMTLSMFASRMVNLSLHEKIRITMESGDSNAALVLEARGMPEAELLEIVKELKTHTDEDPTVSVRMEDGRVMLLFSVVKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ7</accession>
    <name>A0A654DYZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="44"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="973"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1503" mass="159108" checksum="EF807654A6AD73DE" modified="2020-04-22" version="1">MYNLYATIKGVWKVFLLGFSMSIGYLSHAQVNSGGTATTADHNKQIVGYITNWDAWKATNAGLPAQGALTHLNIDYAKYTILNYSFFGVAQDGSLHSGDLRNKNIYQPGAVQAPGDIFFTDIYSSWDMHIIFGEIDPIQYINQEAADRAAAQGFDVTVGGNSWSHPTWGLSGSLPVPLHKEDGAPGLLELAHQNGVKVLASIGGWSMCKHFPEMAADPVKRAKFVADCQKLINTGFDGIDLDWEYPGPYPGMNFTGTQADYGNFLTLVQEIRTAIGPDKLITAAFSADPVKLADFNWPALSATMDYFNMMTYDFNGGFSNIAGHNSPIYSYDGAESPTFNWQSTYDALMSYGVSASKLNFGVPFYGRGVVTNGAADLNAPTLKRQETVQPDGPISTSADFTNWPKDVYDGTPNHYYIKQQALGAGSGWTRYWDDQAKVPYLVKDNYFLSYDDEESIGLKADYIVDHNLAGAIVWTVYGDLEFSGTATNFGTKLKRWSSVNAPLINTVNQQFAAGGTGGNTNPTTSITSPANGASYNVGDNITISASASDADGSVSLVEFYAGGTLLGSDNSAPYSFTWNNVAQGSYTLQTKATDNEGGTAFSSGINITVGTVPNQSPTVSITSPASGSTHTEGASVSIAASASDSDGSISKVAFYANGSLLGEDTSAPYGYDWIAGAAGSYTLLARAYDNENATTDASISVTIESSGGGGDCNNTPQYVENGGYVAGSQVQNDGSVYQCKEYPYSGWCNGAAWAYEPGTGSYWQDAWTYVDECGTGGSNTPPTASISSPVNNASFTTGADITISASATDADGSVIKVAFFQNGSLLGEDTSAPYSFTWTNVAAGSYSLTVVATDNESATTTSSAVTITVANQGNNPPTVSITSPANGASYDEGSTITISASASDDGSVSKVEFFAGATKLGEDTSAPYSYAWTSASVGSYSLSAVATDNEGATGTSTAVNVTVNTVGGCTSDFKIVGYMPSWSGSANDIQYDKVSHIIYAFIRPTTSGGLTAVEQPSKLQSIVSQGHAQGVKVMIAVGGWSDFNNADFEGMASTPTGRNNFATNLLNLCNQYGLDGVDIDWEYPREGNTPQDYEAMMQVLSQTMHANGKLLTAAVAAQGYYADGILSGVFQYVDFLNLMAYDGGSGSTHSPYSYAVSTLNYWLGRGLPASKAVLGVPFYARPSWKSYATLVSEGADPYADTYNGDYYNGITTIQQKTALAESQASGIMIWELSQDITNNVSLSLLNAIYQAAPDNCDPNGSNPNVSFTNPTNGSTISTSSAITLTANATDDGSIASVVFNAGGQNLTASGSGSVYTASWTPASSGSYTLTVTATDNESNTSSQQITVTASSSTCSAPAWQSSAVYNADDQVSHNGTLYRAKWWTQNEDPATHSGQWDVWENQGACGSGARMTDVKVSQTNQQIITYPNPFTESFTVDLEVHESAPTRVIVYNTAGQLVHEQSLGILGKGTHHHSINALHLPEGIYFCHVSIGDQLIIRKMIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ04</accession>
    <name>A0A654DZ04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="305" mass="32321" checksum="4A7E2EB18B7F3B08" modified="2020-04-22" version="1">MTDQTLWGMDMGGTKIEGVVLDNARDKNVLFRERVPTGAHKGYQHVLSQIDKLYQSMAAHTGHTPSRLGMGTPGTLTREGLMKNCNATVMNGMRVKKDLEALLGTELIMANDANCFALAEAKMGVVNKELPNAKVVFGVILGTGVGGGVVVNGQVINGHHGIGGEWGHNELPGFQGRQCFCGKSGDNESILSGPALEWYYESRTGVKKPLKDIVCDARAGVDSIAVDTLHRLMQGFGKAVSLVINILDPDVIVIGGGVGNVDELYTEGKAAIAQYVFNNEFNAPVLKPSLGDSAGVFGAALLVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ18</accession>
    <name>A0A654DZ18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="904" mass="103879" checksum="B45CE85CF19A6497" modified="2020-04-22" version="1">MKRFLLFLSIVLLLGAGYFTYDKWVKNADLTLWSFVPGTSVLVYETSTPLVSLEEIKQTSIWKNLSYLQEVENIDKNIDLLDSLAGKGNFRNFFAENPLLISLNITSSKSFDFLFVVEIQNLSQQTFISKAQAHFQDANYVKRTREYEGFTITELVGDGPDNSFTYIFYKNYFIGSFSAFLVEDAIRTVSYEETTGFDQKNPELKRLTKLERDHGNIYLNIERVPALINIFTQDPTNLDLGKSAFLDLKVGDKTANLTGFSFVDQPTQFLSNFRTSSGAEFDIANIIPIEASWFYHFSTKDPAALGTSLQQYYQATAPDVLKYQAKLLKDADFDVNYTFNLMDEEIGLITMESAATGEHHQLLILEVNDMGEALKFFNSAGERHMLTTGDTLYHEQYGDYEIRKLPVANFPYALLGNLARGFEDSYYLQYRNNLVFSNNLQQLKNFTISIENEGTWTKSLRISHFLDQTNKEASFSLFVNTPRAWNQLLNGLKPSWKDYLAEHQFSFKNLEFLAFQFSTVDDKFYTNLTIYQPNLPNRSIPERIKTLRSITLPDFIKTKPWLVTNHNNKLKEVFVQDTANNVYLIGSDFSVIWDKSISAPIISDVRQIDYYKNGKLQYIFATKEAVHILDRTGAYLPEFPKKLAQIKEIEHFGIIDYDNTKNYRYAITDDKGLMYLTDKDLKPLPGWSPKNFEKPLVQAPLHRRIDGKDVIIAIRKDGKLFVLNRKGDNYASFPLETNSEISDDLFVSSANSLDKSTITLLTTSGELMEISLKGRLTRREQLYKPGAKTDFQIIEDVTGDAYVILRRTENSYEVLDENGLVLFEKNYFSNTPLYHQYYHLGAGTEFIVFVDPGGSYLYLYDREGQLLTGRPLTATQPISVMQYENEFQIYRAVDRNLELISVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ34</accession>
    <name>A0A654DZ34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="10643" checksum="CD795A62E8A94CBA" modified="2020-04-22" version="1">MKYRIIVRRNKVIRFSQNPILTICETETLSLASTTVLGPVAAGIIKAQEHATVAGIIIKSGLTLAAMAVLANTGNKILALAVLELNSVKTKTKAITVIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ80</accession>
    <name>A0A654DZ80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-succinylbenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="142"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="39709" checksum="501CECE7300091B6" modified="2020-04-22" version="1">MLKLEYRDYTLDFKFEAGTSRGILKDHPIVLLKIYDSEHSEVYGLGEAAPLHNLSPEKVEDVKEALAALSPKLKSIPMPDSEEEVFGLVSRLVLPTLPSLRMALETAFLDLINGGRRLIFNNDFYRGISAIPINGLIWMGAEDAMREQIAGKLSAGFKCIKMKIGAIDFEQELSLLRFLRAHDPDLIIRVDANGAFATDEVFSRLSQLEELGIHSIEQPIMAGQHEAMQLLCKRSPVPIALDEELIGVNEYSQKQELLKFIRPQYIILKPTLLGGFGATLEWISLAEQQGIGWWLTSALESNISLNAIAQFAGRFPSVGYQGLGTGQLYHNNIDSPLEIAGAFLGYNQERTWMNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA4</accession>
    <name>A0A654DZA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinol:cytochrome c oxidoreductase membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="18912" checksum="FBE00BD70DEEBC62" modified="2020-04-22" version="1">MAHESNYIVGVYEDEDVLLKAITQVRAGGVKIHEVYSPFPVHGIDDVLGYKGSRLSVVAFLFGLLGTSLALTMQLGMMTVDWPMIIGGKDYAPIPSFIPVTFELTVLLASFGMVGTFMIISNLKPWGKPKLFDKRITDDKHIVAIDLGKNKVEEAAISSLLKASGASEVNLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF3</accession>
    <name>A0A654DZF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoglucanase</fullName>
            <ecNumber evidence="7">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018221">
        <property type="entry name" value="Glyco_hydro_9_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00592">
        <property type="entry name" value="GH9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3 5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CelD_N" evidence="8">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD14004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="600" mass="66527" checksum="FF6BAC1BB3B38E75" modified="2020-04-22" version="1">MISGVESETKSTMSMGNIIRRARLLLLMSVFGSIVGCMVKSQNIEQVTPDIRINQIGYLQHAKKQAAIVEPTSNNFSLINSSNEPVFEGVLLETKYWNKSGEKVAIADFSAFNESGTYRIQCGETVSHFFEISHTPYLELVKSASKSYYYNRASTSLDPSHSGIYHRGYAHPDTLVYVHASAASSSRPAGTVISTPYGWYDAGDYNKYVVNSGIATYTLISAYQHNSGLFDSLTWNLPESDNQVPDLLDEIMWNVRWMESMQDPEDGGVYHKTTSASFENFVSPSEATGERYVVAKGTAATLDFAAVLAKSSVLFRATHPAYAAQLLEKAEKAWRWASVNSRVPFENPNVAMAGHPAISTGGYGDLDFRDEFFWASTELYLATGRDIYMEGITIDDFQIFRVPSWASVETLGLISLSSARMGVSEKLNKQSSDQLMVIADRLTNVWRTAPYKITLDEFTWGSNSEILNQGMVLINAYRLFGNREFYEAALSGLDYVLGRNATGYCFVTGEGSLSPQKVHHRPSASDGVEAPVPGMLVGGPNPRNVNDDCGRQAYMMSHPARCYLDEECSYSTNEVAINWNAPLVYMSSTLQATYLHDFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY1</accession>
    <name>A0A654DZY1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_110090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="408"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD15928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="583" mass="65527" checksum="C44365683B1550DF" modified="2020-04-22" version="1">MINYLIELFIIHSILTVGYLIFLREESDYSKLRAYLLGSTLLSMIVPLLHFPSILALFAPQQGSPSAEVVTYLLNPAMITVQSTSSYDFSFAIWFYALISIWFLVQIARGIIYLVRLERHSEYQVVDGIPVYRASNIQGSFTFFNRIFMDHTISSDQEEFTPMLNHESAHARLGHSYDILFLQLFRACFWWLPSAWWIQKEIKKIHEYQADAYALKLYSMDQYSSILISSILKSNGLSLASSFHDGLILKRLKAMKRKVTQLKPWKVGALTALCAILAIAFACNEQLDGEIKKMGEQSNAISFDQLPDNMKADLEPMKEQLAFIKLEAKEGDNLSDIAGLQDIDEELIHSMNIDKTNNTIYIAMMKDGTNFDYVAEKSKMDGEVFTMVESQPRYPGGMDAFYQYLGQEMKYPLEARKAGIEGRVYVQFIVEPDGTISEVTTLKGIGGGCDAEAERVMTNTSGWIPGEQRGKKVRVRMVLPLIFKLNNEGVANGGKSKGTIIINEVENVNDRMKINANLQEGVWTGTVYAPNGQPLAGVNIVEKNTTSGTVSDRDGSFRLKLINPASEVILRSVGYESVKLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E005</accession>
    <name>A0A654E005_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="35171" checksum="00A9FEE9C9117423" modified="2020-04-22" version="1">MYFATFISINSFNNLNTLSRVSIIVTVYNRVAFLRAALTSALAQSLPPCEVLVIDDGSDTEQAAEIAAIVAEFDQVKLTRLERNGGVSAARNYGVDLATGDYLLFLDDDDLLEEHFLKVAVSYLEQHSTVDVFISRTTLFAERSSARFERLRRYYTYIQQRDHFKSANHPAYFLIYCPAIHSMVFRKGTFQQHRFPEDLTYGEDRYLLMHMRNEGVTFHSTDVVGGRYRIHEQEPPLVVRQLTFIQKLERSGWLRGPFEKAYLHLLEAYFLLKAGQWFKALGAGLYVLRSPRVMGEAVIALVRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E069</accession>
    <name>A0A654E069_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="88" mass="10160" checksum="B92D8ED9246F197A" modified="2020-04-22" version="1">MLKVDLTPQKNNDEEGQEEIILGMMRFDSRIRLVMRLSVKVSLRSTFNNSCSQNRNYNTQKVRCYIFFDGNVPSLIKKLSARSLLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E3</accession>
    <name>A0A654E0E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose sugar dehydrogenase YliI</fullName>
            <ecNumber evidence="2">1.1.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yliI</name>
        <name evidence="2" type="ORF">MARINOS108_120423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="358" mass="39585" checksum="AF3800A5809CC2F0" modified="2020-04-22" version="1">MFSFFFLITLHGWSQPANEFSFGTEVVISDINIPWGMDWLPNGDMLVTDISGTLYRWNGTKLQAISGTPEVVAAGQGGLLDVKVHPDFGKNGWVYLSYSKPMGGNLATTAVIRGKLQGNAFVESAEVFRAEPASDTRHHYGSRIVFDQAGYMYVSVGDRGNRDENPQKLNNHCGKIHRMNDDGSVPGDNPFVGNPIAMQTIYSYGHRNPQGLAVHPETGEVWEHEHGPKGGDEVNIMRPKKNYGWPVISYGINYNGTKFTEITAKDGMEQPEVYWVPSIAPSGMDFVTSDKYGKLKGDLLVGSLKFGYLHRCDVEGSKIMKEEKYLEGIGRVRSVRQGPDGFVYLGVEGKGVLRLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H2</accession>
    <name>A0A654E0H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="81" mass="9652" checksum="0A71CFAF68640B3F" modified="2020-04-22" version="1">MAEYLVRNITEPCDILQKNIFKLGKIIFNRNYGCLTQSIVTFVFKKLKSSSKLEEQITVNGKRRFRFHFWYALQHRFTCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K5</accession>
    <name>A0A654E0K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="249" mass="28244" checksum="7AA346EBF64B7ADF" modified="2020-04-22" version="1">MNLRKAQISIILVTLLVSGCFPPPEFPDVPNIRFSSLQYIDYETARDSMVLKFEFEDGDGDIGLTADEIRTPYHPFNIVIDSRDSIVRYSDPDVVPPLYLVDPLGNVTPFSETDNRPPFNCSSYQVGNFTDIGTDTFYIQKNPYHNNLHIQFLRKKNGAYTKIDFASEFGNASCDVVDFNGRIPIFDRENIGRSLSGTISYAMLSAGFPIILRSDTFKVKFYIYDRDLNKSNEVESPDLTLSKITLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M7</accession>
    <name>A0A654E0M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024791947" evidence="1">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="27053" checksum="3915EC35246E1F78" modified="2020-04-22" version="1">MRILLVLSFLITSSLYTQAQTDYLITSSKDTLRGKVSLLLQEKLTEKVTVTTENETRTFHSGQIIAVRINEDLYKSIKHGDKYRMMKEITPGYLGLYSFRFEDNYDFDPKFLYKVTGEGQEIPTFGFRSVAADFLSECPSIVQAIKNKAYKISDLSSLVNDYNTQCLNTEAKSNVTEGVKEISGLLDQVTELQQLLRDIQSKKDAGEKIPQYMINALEVHAWGNLNGDLRVLLQQLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P0</accession>
    <name>A0A654E0P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="90" mass="10425" checksum="34846A8B8C25CEAF" modified="2020-04-22" version="1">MNALDAFSLIVSEILEVELFSVKGDDSSIGIDHRREMPQYPVIIKGFDDHLWPNTIKISNGNTYYWFILSVLRSITHILSNLQRRKVNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R1</accession>
    <name>A0A654E0R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biotin attachment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="50654" checksum="0D8179D7C9A9EAB1" modified="2020-04-22" version="1">MLNITDDKIDDMLEEGDFYSLHTLKTPGMGRLLAKVSLTLVVSACLFLFLPWQQNIRGSGKVTALNPQNRPQTIESAISGRIKVWKISEGQHVTQGDTILTLSEVKDKYFDPNLLTRLSQQLEAKEQGLAAKMSKKEALERQIIALQETRAIKLRQARNYFQQSILKLEIDSIAFESEKIQFANSENTFDRNQKRYQAGNITLTKFQEIESKFQASKAKLISAENKWLQSKTELINYRISIAGTEAEYQDKISKAQSTVSETLADIHATEGEIAKIKNEFSNMEIRNQQYQIIAPQTGYIVRALKAGIGETIKEGEAVATIIPDSDDLAAEMHVRAMDLPFISTGRKVRIEFDGWPSLQFSGWPNASVGTFGGIVSVIDRVDSKPGSFRILVAPDPDTEAWPEQIRMGSGIKGWVMLNDVPIWFELWRQLNGFPPSIYENQQTTTNTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R3</accession>
    <name>A0A654E0R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine-binding chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="24352" checksum="E0B828D498AFB1FB" modified="2020-04-22" version="1">MTTGRNLKKKSAHPSKEDKGKKAKKVSEKVESADQSWFLTQEELARRSELHKRFKEEIDSLKGKHVHLIVFKLGQESFAMEISKVNEVVPSVPITKMPQTPKYIKGISTIRGKGIIILDLADKLGLVDANEDIKTRSAYTMVVSTERFTVGILVAEVPSNQKISGDTIQSTIDNLSETSLDETYIKGLVKVQGEMVYFIDIDELIEGDRLRARMKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R9</accession>
    <name>A0A654E0R9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">MARINOS108_110014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="393" mass="44230" checksum="65616C2BC9CE4D8E" modified="2020-04-22" version="1">MPSESLDLNSFLYELPEKHIAKFPLENRSDAKLLVYQKGEITHQIFNKTPQLLPKGSFLVFNDTKVIPARLILHKETGARIEIFLLDPVSPSNVYEAAMTSKTSCTWHVMIGNAKKWKSDQKLTLSIDHHVLTAERLSEDQVAFHWTSGDTFSDILTKIGEIPLPPYLGRSATKEDVPRYQTVYSKAEGAVAAPTAGLHFTDEILSELKARGIQTDYLTLHVSAGTFQPIKAKSVEEHPMHREQVLITKQNVQNLLDNDLIISVGTTSMRTLESLFWYGQILSVDSEAAFHITKETAYSFDHVISRKESLEHVLAMMDAANTEVLVGHTEIFIYPGYEFRICKGLITNFHLPGSTLILLVAAFVGEDWKTIYQEALSNEYRFLSYGDSSLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U1</accession>
    <name>A0A654E0U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="25"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="303"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="408" mass="45412" checksum="53D6A562181BEA11" modified="2020-04-22" version="1">MNLAYFIAKRYFLSKKKKSFINVISIISMLVVAIGTMALIIVLSVFNGLEGLLRNLYGTVDPNLVVSANVGKSFVYGPDISNKVNSLEEIVSITEVLEDNVLIKYNNAQRVARVKGVSESFIEQGRLEDYLVFGDLKLTSNDISYAIVGRGVQYDLSINPKNDFYTIQMYFPDEVRPGMLNPEKMYRLKNILPGGVFAVEKSYDENLVYVPIRFAEELFNKKGKRNLLELQLAPSADPNKVKKRLQDLLGSSFLVQSNDEIHGDLYRVLSYEKFFVFLTFSIIIAIASINIFFSLNMLVLDKKKDVAILSAQGATRGLITKIFLLEGCIVAFTGAFTGLLLGLLVSFVQQEFGLVTMGMQTAIIDAYPVKVEWLDVLLTVLSIIVITIVTSIQPALSASKSVAMTDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z4</accession>
    <name>A0A654E0Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="340" mass="37055" checksum="6199D92F5E249D1D" modified="2020-04-22" version="1">MRVFALVKNGAADEAFELREQATPTPKSGELLIESEGFGLNFADVMARLGIYRDCPPLPAVIGYENVGRIKAIGAGVEGFEIGERVLAFTRFGGYADHVISPAMAVAKIPERFSVGEATALATQYITAYFAAEETVSLYRGDHVLIHAAAGGVGTALVQLLKRKGCVIFGTAGSEEKMEYLRELGVDYPINYREVNYQTEVEKLGFGRKLDATFNPIGGDYVKKDFKLLGPGGRLVLYGASKMTEARGNIIKMLKLLFGFGWWSPIGFVTKSTALIGINMLRIADHKPEAFQRSLRAVIDLAESGAIKPTVGKEYPYTQLSDAHAYLEGRKSIGKVAVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E116</accession>
    <name>A0A654E116_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="39831" checksum="E7E1DB841207D25C" modified="2020-04-22" version="1">MFRKVFVFLLVLIIALSALMVMSSDESTVLLSSRINGVSLVNPHFVIDSTQMNAVRRVNGDWVAVIPFGFSRENEPEVHFNHERQWWGERLEGAEELIRLAHACGLKVMLKPHVWQRGSWIGEFDLDSEEKWKIWEAHYREYAMAYARLAEKMQVELFCIATEYKVAVVKRPAYWSQLIQDIKREYHGQLTYAANWDNYENVPFWDQMDYIGVDAYFPLVHEKDPDVATIKRAWAPLVRKLRSFGALYHKPILFAEYGYQSANGAVGNHWEVSQSADQVNMELQARAYQALYEVLWKEPWFAGGFFWKWHFDERHGGPQDLSFTPQGKPAEAVIARWYGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E183</accession>
    <name>A0A654E183_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="94" mass="10974" checksum="0295A82C69714191" modified="2020-04-22" version="1">MNSLLLKENFELITLVLQDNQQNNTFSGDWVSLPIHDSPLLRDIDQMWTPLKETYQRELSKLVWSDDLPSSESILDSMSKIKSFILAYQFPNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G8</accession>
    <name>A0A654E1G8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="40"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="42446" checksum="6BA354025227E3F8" modified="2020-04-22" version="1">MNGDEFDEIDEPIIDVEDSEESAAPMIYDISSYGADLDVEGLVKRLKRGDIFIPPFQRDYVWNQAEASRLVESLLLGLPVPGVFLAKEGESNKMSVIDGQQRLKSLRFFYDGFFNPKDGDTRKRVFKLKNVQPQFEDKTYETLEEEDRIKLDNSIIHATIIKQESPNDNNTSIYHVFERLNTGGRKLTPQEIRSAIYIGKLNEMISELNDHPSWRELFGKKNNRLKDQEMILRFFAMYSLQNEYSKPLKEFLNKFNGRYRNPTESEIERLSDIFKQTTDLILDKLGKNAFRPDRVFNAAAFEVLMVGIANRLDQNINFDSLIQNLETLYKTQDFIDSITRATSDEKVVEQRHKLFNEFVEEYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K6</accession>
    <name>A0A654E1K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nitrite reductase, large subunit, NAD(P)H-binding</fullName>
            <ecNumber evidence="14">1.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nirB</name>
        <name evidence="14" type="ORF">MARINOS108_11698</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="14"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
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    </dbReference>
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        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
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        <location>
            <begin position="317"/>
            <end position="382"/>
        </location>
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        <location>
            <begin position="420"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="616"/>
        </location>
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        <location>
            <begin position="627"/>
            <end position="763"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023063"/>
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        </source>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="835" mass="91335" checksum="682F17E8A0DAB2C5" modified="2020-04-22" version="1">MKKVIVIGNGMVGYKFCEKLRAKAGHQEVSLLVYGEESVPAYDRVHLSEYFTNQSEEKLLMAPAGWYAENDISLKTSQLVTEIDRDQKIVRTHTGETEAYDYLILATGSRPMVPPIKGVDKKGVFVYRTIEDLDQIIAYAKNVKRGAVLGGGLLGLEAAKALMDLKLDAQVVEFASRLMPRQLDEAGSNMLKSKIESLGIEILLNKSTSEIQGNGKLDGLLFADGSQLDTDMLVISCGIVSRDELAAQAGLKTGKRGGFKVNNQLQTNDPHIYAIGEAASYNDMVYGLVAPGYDMADTVVDQILGSGQKQFTGADMSTKLKLIGVEVGSFGDALGDISGSVPIVFEDKNTGIYKRINLSPDRKKLLGGIMVGDTSAYGMLLQITQNGMALPPNPEDLILGARGGESGGNSMMDLPDTAQICSCENVTKDDIVGAIKDQELTDLQQVRTCTKAGTGCGACSPMVGDIFTATLKSMGQVVRKTICAHFDYTRQELFSLIKVKGIQSFDELLDQYGSGDGCETCKPAVASLMASIWNDLILKQDTIQDTNDRFLANIQKGGSYSVVPRVAGGEITPDKLIAMGQVAKKYDLYTKITGGQRIDMFGARLNDLPAIWRELIDAGFESGHAYGKSLRTVKSCVGSTWCRYGLHDSVSFAIEIENRYKGMRSPHKLKGGVSGCRRECAEAQSKDFGLIATEIGYNLYVCGNGGANPQHAKLLAGDIDEKTAIKYLDRFLMFYIRTAEPLNRTAVWLNKLEGGIDYLREVVVNDSLGLGEELEKDMQALIASYHCEWKEAIEDEGMKARFRHFSNSDEHDPTQQFVPMREMKKPADWQTVTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M7</accession>
    <name>A0A654E1M7_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Mycothiol system anti-sigma-R factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="88" mass="10322" checksum="56ED06CBF24BBC7F" modified="2020-04-22" version="1">MSDNSEKKGSNDCNEFAKCLQYLHLMLDNEATEEQEIYLKNHIHKCMVCFEQYEVEKQIRELLRSKLTNQKVPADLAQAIRNKVFQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N1</accession>
    <name>A0A654E1N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="15208" checksum="26EF823026677D08" modified="2020-04-22" version="1">MFSKACEYALKVMIYLCSVTEAGKLAGLKDIAGAIDSPEAYTAKILQQLVRAGLLESLRGPNGGFKVADRDITLMEVVTAIDGEHLVKSCVLGLKECSGEHPCPAHDKFIAIRDHLKGVLTTTYLSDLKGGVIEGNRFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R2</accession>
    <name>A0A654E1R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Hybrid sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024814492" evidence="5">
        <location>
            <begin position="33"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="865"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="1265"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1365" mass="154224" checksum="CD83075B9FB39867" modified="2020-04-22" version="1">MVFLWCLSLLDRLKFKSLFCILAMCSWSAVFGQSEVITFQKWNVEDGLSNSIIRNIAQDSAGYLWLATEHGLNRFDGLQFKHYFSVPGDSSGLSHNSLFGLGIDASGMVWVGSDYGLNLLNPESEEVQHFFYDSLDENSLSDNYVRCVFVDSRHRVWVGTQNGLNRYQPVSGDFFRYPEQREFDDANRRRIHSYNRINTVFEDNDGAIWVGTDGGGIKIYRSGGEEFEEFFIPGEDVKRQIIRKIYQDTAGDFWIGTDGGLAYFQVETQQFDFYTENGPEGLSNQFVWGILEDQDGLIWVSTYRGGISLFDKKLGQFVAHLNEDTPGSLSSEMIWTLFQDQDGGIWVGTDGQGGLNYWNPLAQKMRHYLGVQPNESKHVVKDVLELTSDILLVVSTQGFFAFDQRDQFVEFLEEWSLEPMVRLLYREGEALVVSGDEVVLMDSLLSPKKTYKYGDGVAEKHPTALALEGEILWIGTLSAGLHQLNLKSGETKSFFSNGSTSLYQDSRSIKALLSRNQSELWVSSVRSGLFRMNTVTDEIKQFFYHTKDFFEPTITSIVATSDSVLWLGTQNEGLIKFNTHDGSYEALVSEGTLTNEITALIAEENGKYIWLTSKNGMGRFDIETGQFHEFTIEDGLQSRVFNQVSHQGRSGAFYFGGVNGINAFNPDEVILNPIRLKVFFEDFMINEVSDPERLRLASQGPVSLSYDENDLSFSFVAPAFLHANKVRYGYRLSEKEDWRDLGSRRNLNLPKLSPGKYHLQVRATNNDGFPGGASSVFLEILPPWWQTWWFRLLFFLGVMILLGSVFVYRVRRIQKQKIALEHIVAERTSELKAERDKAESDKRVIEKQAVKLQELDQVKSKFFANISHELRTPLTLINAPLEAMLDGDFGPVDPKMLKALETARSNGGNLLVLVEEILDLAKLEAGKLRLIKNPVLIGELIDQLFAPYAFGFAQKKIAGEITLDIPEGLTLMIDEKKFSKIINNLLSNASKFTSAGGKIHLLARYQSQDGTMHISVSDTGSGIHPDDLPFVFDRFYQAEKDNKARGGTGIGLALSRELAHLFGGQLSVSSVQGEGTEFVFDFPAELSEYSLIEEVSEDETYKKEILQGLVQSTRVYSEYFQVDMPAVLIAEDNDEMRSFIHGIFQPYFDVTNASDGQEAWDHLESGRFDILVSDWMMPRLDGFELMNKIKETPELSGLSIVMLTARSSEEDKLQALTAGVDDYLTKPFNKWELLARVKNILQNRMARKDKESVNQPLSVDQEFMNRLQGIVSAELKSGLLSVSYLASELAMSERQLQRKIKAISGLSPQQLIKEVRLQKSRAMLMAKRVHTVAEAANLVGFDKTEYFSSQFTQRFGKRPSDLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R4</accession>
    <name>A0A654E1R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NUMOD4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010902">
        <property type="entry name" value="NUMOD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07463">
        <property type="entry name" value="NUMOD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUMOD4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="168" mass="19945" checksum="84664D6542A17AF7" modified="2020-04-22" version="1">MANQTDEIWNPIDGFSNYEISNKGKIRSKTRKTWHKGSKTNMTIKGKLMKQRWNKMCKCYFLDLIDDEKRRRTVYPHKEVAKAFLENNDPETLNMIIHEDNNPRNNKADNLKWVSASDHMKWQFEVGNKDNFKVWKTRKKRYKNGFKPDTVLPGRPKKAKEEKELVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T6</accession>
    <name>A0A654E1T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aryl-phospho-beta-D-glucosidase BglC (GH1 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024824225" evidence="3">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="38402" checksum="1307839D54D68202" modified="2020-04-22" version="1">MRLLICTLFLVVNSALAQQPLERITVNGNQFVNESGKKVVLRGYNASDPDNLIKQGQWGRAYFQEMKAWGSNVVRFPIHPRAWRERGESAYLTLLDSGIRWAAEQSMYVILDWHSIGNLKSGLFFRPGYETTLKETFSFWQTIARKYGDNPTVAFYELFNEPTTNNGQLGVCSWDEWKAINEEMITIIRACGGQGIPLVAGFNWAYDLSAAFERPIEAVGIGYVSHPYPQKRNQPWESQWTMDWGRMKEKYPVILTEIGFSGAEERGAHVPVISDERYGEAITRYCDEKDISYVVWVFDARWAPSLFSDWEYKELTRHGKFFKTKLNTYQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y1</accession>
    <name>A0A654E1Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="80" mass="8696" checksum="89C6A54CCD6C2369" modified="2020-04-22" version="1">MTIIEAIGWLGAGSLLVGFVLNIFQKIAAGSFPYLLLNLGGSALLLYNAYMNGAYPFVVVNLFWVVFSGIKLFQLSFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E290</accession>
    <name>A0A654E290_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase YhcX</fullName>
            <ecNumber evidence="3">3.5.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhcX</name>
        <name evidence="3" type="ORF">MARINOS108_11898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="223"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="507" mass="58325" checksum="2D0FF2C64CE150E4" modified="2020-04-22" version="1">MKKIKQVEVRNIRMADYQELKDAMIEAYSSWPGIFWGEEYINKLLEIFPEGQFGIVADGKVVGCALAIIVDYGKFGDEHTYKEITGNYSFDTHNPTGDILYGIEVFIRPDYRGYRLGRRLYDARKELCEKLNLRAIIFGGRIPNYHKYVDTLKPKEYIDRVKFKEIHDPTLSFQLSNDFHVKKLLTDYMPGDEESMEFATLLQWDNIYYKRKGANKPEYKPVVRLGLVQWQMRPYNTMDELFQQIEFFIDAVSGYKSDFALFPEFFNAPLMGQWNNLSEPAAIRELAAHTESIRDRFVQLAISYNINIITGSMPLMRDGNLYNVGYLCRRNGVWSQFEKIQVTPDEVKFWGMSGGKGIQVFDTDCGKVGVCISYDVEFPEIPRMMAAQGMKLLFIPFLTDTQNGYSRVRNCAQARAIENECYVAMAGSVGNLPKVHNMDIQFAQSVVFTPCDFAFPVNGVKAEATPNTEMILVVDVDLDLLKELHESGSARNLKDRRTDYYDLVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A8</accession>
    <name>A0A654E2A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="958" mass="107710" checksum="DA3A458E0188C625" modified="2020-04-22" version="1">MIPMDRMTQYLPKALVALFIAVVLAFIFAYSQGYDSSIGWNVTTTAESEAFYTLPFKKGPFQFSFQGEKYTLAENFSAGPIERHFTTDAIILSVILLGLCLILTVTTYLSRMWFIGIMGLFIFFIMTLHLPEVRLFGFGERSSVAVVIVLIIYLLPAYLFHAFIKDVDFGWRLLSFVLLSAGIVFFSGVETVALQEQFIAGSYFGMIALTLVFLFLIAEENVFGILFLITQSKGGRSNHVHFSVFSFVYLGILLAHYGKKAAFWNLDIAFFSPYLLLALSALVALWSLKYKRSLFEGFISVGYAQILYCSLGMVVIGFITLAFSRGNDSVYEGLHYFIIYTHMAFGTMFFLYLFWNFVSPLGQGMQVYKIAYKSQSFPYVSARLAGLAAIAAFFFLANKEPFLLFRAGHYNYLGAQAEAQGQDRLAAEYYREGSIYGYDNHFSNYKIGYRELQKGDISEANYRFGRAALRYPSPQTFVNQSATAAMSSETTPSLISLQNGLRAFPDNNQLLNNLGLTYADMGKTHEAVNTLQQAQPKSQWTNAALVNLWKVREVDSAQAEQDYEAGNLAVKANILSALMDANVQTSLSFDSASLFPSYPLHRLAFLINAAWYFEDAKVALWLDQSLSGQLDERMYWAGKNAMVMSYFKAGQVNNALQALDYLKTEVPTRESGKYLNQMGLIALSQHAPKVALDYFDQATQAGFEDALLNKAACLLELGEFSKATEWATYLVTLDSSYAALKKDITNISNTESLTPDQQLFRLYYLYRTYSAGEINALLSQADEQYIRSLWAKVANEQLEEQNYDQLKTYRAVFNSLLPPEYFEEPDALLTLVDGGVPQNGHYLSEILALKDQNEQTAALVNLAGMNSLNEPLVLAISRILSTTHLSESYDVLVNAINFNPRSVALHQQYIMAALEMGLENYANDALQKLTTLTTQNDYQLFYQQYLDKKKALEASGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B0</accession>
    <name>A0A654E2B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="34015" checksum="B2A5B88659FAC5D7" modified="2020-04-22" version="1">MIQYNPRSWFSLIFDVYSRYVIKLLFPLLLFVGVFTLLLCFLVIDVFNLHYGGTIAFHSILGVILGLFLVLRTNTAYDRWWEGRKLWGQLVNDSRQIAIKVDAFLPKEATEDREYFRRMIPNAAFAIKEHLRDSILIGEMDTINDEIKNRIIKSKHRPNMVNRLLYDRVMKCMKEGTITAEQLFILDKELKGFTDIVGACERIKSTPIPYSYSMFIKKFLFIYAITLPVSFMWDFGYWTVFIVMLAFYFLVSIELISEEIEDPFGTDINDLPLNEIALKIKRNVSEILHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C7</accession>
    <name>A0A654E2C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter, sugar porter (SP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="8"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD14407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="444" mass="49164" checksum="2C383468374CE0F0" modified="2020-04-22" version="1">MNRKLLVASVVASLAGFLFGFDTVVISGANLPIKELWQTSDWFHGTFIMSMALWGTVVGALCAGYPTNVWGRKTTLIWIGVFYFISAIGSALAPDPYSFSFFRFLGGLGVGVSSIAAPTYISEISSANNRGRLGILYQFNIVFGILAAFISNYLLEGVGGDLDWRIMLGIEGLPALLYTLMVFGIPRSPRWLVLYKHDADRAKKVLENLTDSKEEAAEMLYAIEEDYERTKGDSDKVFSPKYKKPLVLAFLIAFFNQLSGINFILYYAPEILVKAGFGSSGSLFSSIAIGLVNLLFTFIGMSLIDKAGRKQLMYIGSLGYIISLFMVSYGFYSEADATFKLIFILMFIASHAVGQGAVIWIFIAEIFPNKVRAYGQAWGSGTHWVFAALITLSGSVLINTFEPWVAFAFFGCFMILQLLFVHFMMPETKGKSLEEIEEELMEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F1</accession>
    <name>A0A654E2F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_10220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD10762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="458" mass="50991" checksum="224FB5BD50FDEFBC" modified="2020-04-22" version="1">MDVEILSRIQFALTISFHYIYPPVSIGLGLIMVIMEGLYLRTKDPAYEQLARFWTKIFALTFGIGVATGIVMEFEFGTNWATYSRYVGDIFGSALAAEGIFAFALESGFLGILLFGWNRVSPVVHFTATLGVWLGSMFSAVWIVVANSWQQTPGGYHIVGEGMEARAEITDFWAMVFNPSSVDRLSHVWIGSFLAGAFLVMSVHAYYLLKNRHIEVSKKAFKIALVVGVVASLSQLFTGHRSADGVAVNQPVKLAAMEGHFDSLAAADMYLLGWVDKEKQEVSGIKIPNGLSFLIHQDFNAKVKGINAFPEDERPGQINAVFQFYHLMVGIGMALIGLSLLGCFLWWRGKLFDHRWVLKAFVVAVLLPQIANQAGWFAAEMGRQPWVVYGLLRTSDALSKVVTANQVIFSLVLFSLVYSLLFALFIYLLNKKIQHGPQDGEMIDQRPHQREIVDAIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P3</accession>
    <name>A0A654E2P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="28188" checksum="1516146065F7AD7A" modified="2020-04-22" version="1">MAKLRILVAEDNLVHASKMEMILEELGYDLIGIFNNEAEVMRMFNATLPDLVILDIDLKDSDDGVSIASKINNIRPTPIIFATSFVDKETISRALQTDPYAYLIKPIEKPSLQAAIELAVFKLGKKDQEGSAGKFSGWSEDLVLNESFFIKSGSKLVKVAWADIRWIEVSQDRYCEIVSEKRSFQIRSSMNQLEEKLNPAVFVRIHRSHIVNIEKVDGVDDVDMVVEVGEKSLPLGGAYKNNLMNRLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q0</accession>
    <name>A0A654E2Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_140005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025028917" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="410"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1002" mass="110145" checksum="4093F9E383BE6597" modified="2020-04-22" version="1">MRSYFTCLILLLLAHLSWAQEMTLKGKITDSKTSEPLSGVSIKLPGSGNSTVTNASGEFQISISDGYENVVVSLEGYQSQKIFLGGTTNLNVSLKKGKAEEATSVGFGSQSKTEMTSSVSSIETNDVSPSPLINLEQANQGKTTGMFVQNSSGKLGEGTTVRIRGGSSLSASNQPLYVIDGVPLTSGNQSNINPANIAKIEILKDASAGAMYGARAANGVILITTKSGGSGKMKIDADYQFGISQTPKKLDLYSPEEYNQQVIEYTLRSLSLDQFVTKERLEQWEASGDRTINLPNGSAVTLPSFYDSLNYNTDWQDEVFRKAYSHRANLSLQGGTEKLGYFASMSYTTQEGILIGNKYDRLNGSLSLDSKISSKLSANLNLNYFYSKDFRLKEDQDLGAPLQAIVLPPSDGYNADNNYQLIVRSLEYNPLTEVNFSDNLGFNNSLVGNLGLKYDFTDELTFDINGGMDFNDARQEIRQGPETRDGALTGRSQLGEQNLKNYIFNGWFTYTPELSDNHKVSVMLGASYQESNTTSSYRVANINSVSQLEGLDENNPSLTIVDIPGQASRFASTFGRFNYTLMDKYIVQVSGRMDGSSKFGPDNRYGFFPAVSTGWNISNESFMESVSPVSFLKLKASYGLVGNTPQDDFLYRSNYYNIRYGNRDGIRLSNLANPNLKWETTAQMDIGLDFAFLSDRISGSVDYYKKTTTDLLFPVPVSQTSGFASVLKNVGSMENKGFEFNLSTVNVETGDFSWTTDFNISFNQNKVTDLQGSNLIVGVNAFLEGESAGVFYMRKYVGVDNVTGEALYDNGLGGTTSDWESAPRQIVGNPNPDYYGGFTNSFRFKNFELSALFQFVGGADLYYETGEFLANSGILNLGQLATQADRWYAPGDDAEYPVLDPFQENTFPSTRWLQDGSYVRMKTLTLTYNLPSDMVAGWGMQYMSIYVGGTNLLTFTDYTGYDPDVSYFDPLDGVVGQNISRGIDNFTAPQPKIFMGGIKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y0</accession>
    <name>A0A654E2Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="30711" checksum="0E2AE459733437C3" modified="2020-04-22" version="1">MGEIIVKKTGLHTSIQDLGRGHWRHFGVPLSGAMDQRSAQLANLLTNNEEDTPVIEITMMGPQLQFTESAIIVLTGANLSPNLDGSAIGMNQSVQVKGGQTLSFGKPIQGIRTYLSIKGGFDCPKVLGSYSQYPMVTPSGSLQQGDRLAYKSQTVSGRNHALIHTDPQHFTNKILKASPGPEFDLLENSTQQMLLTSSFLIQGNDRMGYQLKHPDMPPHQMEMVTAPVIPGTVQFTPSGQLIVLMRDAQVTGGYPRVLQLTKESIDQLAQKTNGQSILFQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z7</accession>
    <name>A0A654E2Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="20656" checksum="3C1369CC046B057C" modified="2020-04-22" version="1">MEKLTHLWNGATYQDHLLQSYRGFHLTIQSLLIAVGTGLSIAVIAFADLPRVWAAYIILLAITTLAVYLLWSMQALIKARGIDVDYFHKEIILEEQSLPREQQVLTAFKVEQKFNRGKVDIHEYFASFELTPAIRNQLTEKGKGHTRKLLDKYLFWGFYAVWLSLHVVCIWRITDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E304</accession>
    <name>A0A654E304_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="389" mass="44580" checksum="15F2E1E52464CA8F" modified="2020-04-22" version="1">MKNVLVLIHTPTFGGPHNQMIRLKEPLAVYGWELIVVLPEEEGDGYDRLKSAGIQVIRTNISRIRALKPWRNIFYFRNLRKEVKNLEEIVLKYNIDLIQVCGLMHIHGAILSRRLKKPLVWQLLSTFAPKILRAIYTPIVGKFAHVVMSTGMMIVDKHPFNEQVKSKLIPFYPPVNTADFTYTAEKRKLARRYLSIPEDGFLISTVGNQNRQKSHEQFVKVAAMFKNTESIYFRICGQSTDSQREIYTKSVLNLAKKYDLYCNDFFDVLEPGKITVDQILSATDVFLLTSFAEGVPTAILEAMSVGLPIISTKVGSIPEIVKDQRNGFLYDFDDLSSVKSAIEELYMDPEKRRMFSINNRQDAIELFDTSKCVERHVEAYRLAMSKNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E330</accession>
    <name>A0A654E330_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="214" mass="23488" checksum="F9DE52281D413E04" modified="2020-04-22" version="1">MSKVKVTAFSVSLDGFGAGSDQSMENPLGVGGEELHEWMFSTKRFQQMGGRDGGMEGIDNEFVEKSFENIGAWIMGRNMFGPIRGPWPNDEWKGWWGENPPYHVPVFVLTHHARPPVTMRGGTTFHFVTGGIEVALEKAREVAHGKDIRIGGGVSTIRQFLQAGLMDEMHLALSPILLGSGEPLFAGLDLPQLGFTDTQVTYGEKAAHAFLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E370</accession>
    <name>A0A654E370_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="600" mass="66077" checksum="AEC04713DE07B4A1" modified="2020-04-22" version="1">MLLHTLDWIIIAIFFAIVLGIGWVASRTAGQSSEEYFLGGRGMPWWLLGVSMVACTFSADTPNLVTGFVRESGVSKNWAWWAFLITGMVTVFIYARLWRKSRVNTDLEFYEIRYGGKLASFLRGFRAIYLGVFFNTLIMGSVTLAAIKIGAVMLGLEPWVVVVGASIVVVIYASLGGIKGVVWADFFQYGIAMFGAVYAAYVAVSQPEVGSLSELMSNPIIADKISVIPDFSSASVWVPLLLIPLAVQWWAVWYPGAEPGGGGYIAQRMLSAKDEKNAIGATLLFNFAHYALRPWPWIIVALASMVIYPDLDSIHAEFPDIDPTYLKDDIAYPVMLAKLGTGWIGLVVASIIAAYMSTIGTHLNWGSSYFVNDFYKRFLKPDATDKQMVAMGRWTTVLLMIIAGFLSLYVLDNATQAFNILLLSGAGSGAIYLLRWFWWRINAITEITAMIVATVVAFVLVLGVDDATVATEVLDGFTMKLLITVGVVTVSWVSVTLLTRPENAQVLRNFYRLTRPGGPGWRRVVEEARADNDPCDHGEGVVWQMPLQVLLIFIGLVSVYSALFSIGSFVYQDVWLGVCLAAVSLLSTVALFKVFGKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E377</accession>
    <name>A0A654E377_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="729" mass="79908" checksum="987EA66C6B3661C2" modified="2020-04-22" version="1">MRPYAESVFMKKWITSLVSFWSVALTFCFAQNIPIDTWRTHFSYNNARILEGGNGKIFCAVENGLFYIDLATGAINTLSKTDGLSDAGITALSYSEDFKTLVIGYESGLVDLHHDGKVTTIRDIKNATLVGSKKIHQIITHGQLAYVGTSFGIIVVSLERQEIVDNHRSFGPNATDVTVTEMLVFGERLFAITNAGLLSASLQSNLSTYTSWILEADSASFSHLTATSENVFVIKNDTLIAQRVGNQWIDASWASDESIIDMKADHEFLYLLTSSNIHQYQSTGPTALKSIAHLQANTFLPSDGFWIGDLRSGLIDPAGQSITPNGPLSDDITEIRYIDQHCYAFYGPHPEDYYGQTDSLGYSLFDNTSWGTETIEGFYNITDVAFFENNHYFSSTGYGLYNQTEGSLVTGLSKNLEGYDPLIPQLTTSSDLLYIPSYESGEPLYTLDEAGELNPYSLSFIGTSFPLAVSLSQRGVLWITRGINDGGGFIALNLNNQDFRELTTADKIPSNQINGVAIDLSDETWIATVGGPAIFTEASFIFDDLNAIIPIYDNKEVFEDESVTAIAVDGGNRIWMSTREGLWIFDNSLSQLEAHFTTDNSPLPSNMVLKMAYNSKNGEMFILTEKGLVSYRSGSSAGGITNRSVSVFPNPVRPGYEGMVGITGLVRDASVKITDVNGKLIREVAAKGGTASWDLLDYNGQRVRSGIYILFNASQDGSETHIGKIAVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H0</accession>
    <name>A0A654E3H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046289">
        <property type="entry name" value="DUF6326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19851">
        <property type="entry name" value="DUF6326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15600" checksum="EBD7C32AAE7B2997" modified="2020-04-22" version="1">MLDNPRVNIKIKLSALWTSVVFCYLYGDYFELYVPEKVDSLITGVNVLDSPSKLLIASIILAIPSLMVALSILLNPRVNRFLNVFFGILFTLMMLLIGVNSLTPWYSFYAFLAFLESLITILIVWFAWKWPREAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N8</accession>
    <name>A0A654E3N8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3 8">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">comB</name>
        <name evidence="9" type="ORF">MARINOS108_20683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ComB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3 8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00490">
        <property type="entry name" value="ComB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="PTHR37311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="235" mass="25141" checksum="26BBE97117B49614" modified="2020-04-22" version="1">MNVIEVCLTPELIHQYTLQGKIAVVVDIFRATSCMVTGMAHGVKSIHPVASVEECLALGQQGMVTAGERGGIKVDGFTIGNSPFEYMQEEFKGQSIAVSTTNGTKTILASTDADEILIGAFLNLQALVDYITTQRKDVVVHCAGWKGTVNIEDTLFAGALASALAESHTLSGDAALLAFELYEANQSDLLKIARASSHAQRLSGFGVEKDIEFCMDQSLYTAIPTYNNGCLKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P3</accession>
    <name>A0A654E3P3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme exporter protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="24709" checksum="26859066D4F5D99A" modified="2020-04-22" version="1">MLKQLRWLIYKDLQIDWRSKYPLAGILLYITSLIITSYLSFTGFIEPKTWNALFWLILLFISINAVAKSFSQEEDRTLYYFHLIRPERIILAKLIYYSLYQWLLIGGALLVYTIFLGFPVKEMTPFLVNLLVGSFGLSSAFTMVSSIASKTNNNAVMMAILGFPVIIPILILAISNSKTIVLGGSWSDINDNLITLLSVNVIIIALSYILFPFTWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P5</accession>
    <name>A0A654E3P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="20757" checksum="6B2FB6BD763CC74B" modified="2020-04-22" version="1">MKNLILATSVIFMLIGCNNSSEQLPAEQSLGINVSASDILKELSLDSTIELGQEFSGNLYKNAGGFITVDSAKLKLERGRAIGNVLNQPYGFVFGLDTLDKFIKNIRDVNALYKKDTIEAVRIYLVKTHRKSVTAPYRRFKHFDVMMVPVVSDGSNFFNLGDVVDSLAFTPDYPGVLNNSLPCPDECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q3</accession>
    <name>A0A654E3Q3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ORF">MARINOS108_120120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="131"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="246"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD16271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="374" mass="41646" checksum="F62C7A0613F4DF26" modified="2020-04-22" version="1">MKFIVSSSYLLKQLSAINGVITTNPVVPILENFLFEITDGTLTITASDLQTSMITELEVEAKENGSIAIPAKILLETLRNLPEQPVTFSIDADTYSIEINSDNGRYKLSGENATDFPKIPTVSDGYAVNMSSGVLAQAINSTIYATSNDELRPAMTGVYIKLDETNTTFVATDSHRLIRYRRVDIASDMAHNMIIPRKALTLLKSTLPSENTNVNLEFNASNAFFSFNNVKMICRLIDERFPDYENVIPSDNENAMNINKSELLSSLKRIAIYANKTTHQVRLKITGSELLISAEDLDFSNEASERLSCEHDGEDIEIGFNAKFLIEMLNNMDAEEITLKLNAPNRAGIILPVEKDENEDILLLVMPVMLNNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U7</accession>
    <name>A0A654E3U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="9568" checksum="C647A1A56B27655C" modified="2020-04-22" version="1">MIEIFKTDVMSTEDAYLLVGQLNHQLGYMANFDLQDCDHILRVVNSAGEVEPQIVIRMLEKQGFCAEVLPDVVEHPVDRLKQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E444</accession>
    <name>A0A654E444_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="95" mass="11255" checksum="88A4C179D0A415AF" modified="2020-04-22" version="1">MTKDNSHTFTSAFRKFLTHEKLDVRYREKLLVESWETIMGKPIASRTTSLFLKERILFVKFSSAPLKQEMLNNKERVKSLIEKDFGDLVDDIRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C9</accession>
    <name>A0A654E4C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024977954" evidence="1">
        <location>
            <begin position="24"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="601" mass="62768" checksum="6FB5157E6EBCDF75" modified="2020-04-22" version="1">MRRTKRLFNHSSLLFLAGAFLFAGCGDDDTTDMEPEEQMPSGMLTVSSQTISQNTIRVSNVNFDSKGWVVVHASNEDGTPVVPGIISEPLLVEAGSQNDLELTLTEVDDLMDGDKLWVMLHTDDGIEGTYEFDGANGFDGPILSDGNIVMTDITVSAPGITASNQVVNENWVTIGEVKAAVDGWLVIHADNGSGAPGPVLGQTMVSAGMNSDVAIDLGDAVFAGGEMLFPMLHIESPADGMYGFPENGDDPEVFANDVVVIGIETLAPTGSISAVGQVVQGNMITASELTLNATGWVVVHASNATKDGPEVPGIISTPVQLPAGTNSDVAIELNSDFALSAGDVIYIMLHTENGVIGEYEFDGANGFDGPITTAPMTLEAPSGSFMASNQVVSQNTLMVESITVGQPSWVVVHRDNGAGSFVAPGIISNPVAIDAGTTENVAITFKDDEPLSDGETLWIMLHNESGTIGAYEFDGANGFDLPITFSSIDIEAPSVMVSDQIVMNNMVTIDEVKAGVDGWIVIHEDNGNGAPGPVLGQTFVNAGSTSDVMVDLGSATVAAGDKLFPMLHIESPADGEYGFPDNGDGPEVFNSDVVVVSFTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U2</accession>
    <name>A0A654E4U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphosulfolactate synthase</fullName>
            <ecNumber evidence="2">4.4.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yitD</name>
        <name evidence="2" type="ORF">MARINOS108_20900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043817">
        <property type="term" value="F:phosphosulfolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="SSF102110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="26216" checksum="0DEF0622AD678776" modified="2020-04-22" version="1">MIMDKGLSIREVEDMIDISGDFIDIVKLGWATSYVTKNLKEKLAVYKSAGLPVYLGGTLFEAFIVRNQFSDYQKVLDQFGLEYAEVSDGSIEMNHDEKCGYISTLAKQVTVLSEVGSKDAAKIIPPYKWIEQMQTELDAGAWKVIGEARESGNVGLFRDSGEVRQGLVEEILTKIPEDKILWEAPQKAQQVWFIKLIGTNVNLGNIAPNEVIPLETIRLGLRGDTFDYFLDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z6</accession>
    <name>A0A654E4Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">tsf</name>
        <name evidence="9" type="ORF">MARINOS108_20931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="72"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="29671" checksum="B07F1C581B393F6E" modified="2020-04-22" version="1">MAITAQDVNKLRQMTGAGMMDCKKALVEADGDFEKAIELLRKKGQKVSANRADRETTEGIVVTRTNEDKTKGVVLALTCETDFVAKNEDFVALANLAADLAFENAPADVEALLALSVGSITLGDKIIEATGKIGEKIDVKFYETLAGEAVVPYIHSNGKLAVVVVLKNVNGADVEEAGKDVAMQIAAMNPVAVDKDGVDPKVIQQEIEIGKEQARQEGKPENIIEKIAEGKLQKFFKENTLLSQSFVKDNSLTIASYLNGVSKGLTVSEFKRISIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E515</accession>
    <name>A0A654E515_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026445">
        <property type="entry name" value="AlkhydPrxdase/COmuclacdeCOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04169">
        <property type="entry name" value="perox_w_seleSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12363" checksum="597E1F3EA7989FC3" modified="2020-04-22" version="1">MKETYYNREDLGKFGNITEFQQELGDKFFDYYGSVFAPGALTAREKSLIALAVAHAIQCPYCIDAYTSDTLKKGVDEEQMMEAIHVAAAIRGGASLVHGVQMMNQVKDKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E533</accession>
    <name>A0A654E533_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="8143" checksum="A5F4FA162D7AFCCD" modified="2020-04-22" version="1">MDIQAEKYSLIEYISQIADITLVEKLKQFVKANEQDFWNDLTLCPTSIIEMIKSRVFLSSTARHPSKTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E570</accession>
    <name>A0A654E570_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfotransfer_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="31222" checksum="1F0B5D87F65CB9D9" modified="2020-04-22" version="1">MDKIKLYVIGYPRSGNTWVTRLFAHLYNLEVKVVMGNHEIATEINDRISSDSKNGFIGKGHYTIDNFRQIDSDPERVIYLSRDFPSVAISSFFYFYESPDFQEYYRLFRWTDLLLKPKKIFVYRRNRKRLNTFIEDLLLNGVPWFGTWTNHLEGWKSNSLKGACCFSDYNQLVSNTRSEVERIIKELQLPKLEEGIIDMAIASESFDLMKKRNSTDQRKGEGRLMYRKADPTDWRNYLDDELLARIEDHLRGDASPNAHFTPSGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G2</accession>
    <name>A0A654E5G2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease R</fullName>
            <shortName evidence="5">RNase R</shortName>
            <ecNumber evidence="5">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rnr</name>
        <name evidence="8" type="ORF">MARINOS108_140149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="636"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="720" mass="82493" checksum="B04E812F5892A116" modified="2020-04-22" version="1">MSKKRKNKTEKPQQKSSNVKRIKDQVRGVFAHHIGERFSYRQLIKELGLRDKKSKESLKDILFGMESKGQLAKAPDGRFISAYEPETIEGRVDHVNARFAYIISDQSEDDIWVKTDDLKFAIDKDIVKVQITKPGNDGFRPEGKVVELVSRAKEEFVGRIELSPKFAFVVPDSRNIHFDVFVYPEKIMKAKHNDKVMVKITRWHDAKNRSPMGEVTAVLGAAGENEAEIHSIMAEFGLPFKFPESIEDAAAKIPTEISAEDLKDRRDFRNITTFTVDPEDAKDFDDALSIEKLDNGDYEIGIHIADVSHYVTPKSALEKEAVQRATSVYLVDRTIPMLPEKLSNGLCSLRPNEDKLTFSASFVMDTEGKVKKKWFGRTIIHSNRRFTYEDAQIGIETGEGDYATELQLLNSIAHKLRDKRFKNGAVNFETTEVKFQLDEKGKPLAVVPKVRKDAHKMIEEFMLLANREVATYIYKWGKGENGKYTFVYRTHDNPDPEKLENFSKFAAKFGHKMNVSGDISQSLNKLMDEITGKPEQNVLEQLAIRSMAKAKYTTEPKGHFGLAFDHYTHFTSPIRRYPDVMVHRLLWHYLQGGKSVEVEPEEKKCVHSSEREKNAADAERASIKYKQVEFMQSMLGEDFEGIVSGVTEWGIFVEIVETKCEGMVRLADLDDDFYEFDEKNYRIIGKRNKRIITLGDKLMVKVVKTDIDRRTIDLDLVQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G7</accession>
    <name>A0A654E5G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette subfamily F protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="323"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="632" mass="72215" checksum="605BA8C184EA78BC" modified="2020-04-22" version="1">MISINNLSYYIGDRPLYDDASLFIGPKDRIGLIGLNGTGKSTLLKMITGEDQPTAGEINMSNDTTIGFLNQDLLSYLTDDSILHVAMQAFAETMKIQKQIDEVLHEMETNYRDELVDKLAKLQERFETNDGYTMQAKAEEILEGIGFSTQDLQRPLKEFSGGWRMRVMLAKLLLEKPSLLMLDEPTNHLDLPSIQWLENYLQSYDGACIIVSHDRRFLNASINKIVEVSAYQLNMYAGNYDFYLEEKELRNEIQQNAFENQQQKIRQAERFVERFKAKASKAKQAQSRAKMLDKMERIEAVADEAAAVDFKFKFKVKSGRHVVKMENISKSYGDLNILSHANAHIERGDKIAFIGANGKGKSTALRIVAETESFQGTLQKGHNVTTAFYAQHQLEALNIQNEILEELKQAGSGKTDQELRGVLGCFLFTDDEVFKKIKVLSGGEKSRVALAKTLITESNFLMLDEPTNHLDMMSVSILVQALQQFEGTFLLVSHDRDFISKVANKIWWIEDHEIKEYPGTYEEWEWWYNREQEKKKSSPQPQNSEKKEKAKVAVEKPRHDDTQKQLEKEIAQLEGKIEALESEVTKLETELSKPEVFGDAAKMEKTTNRYQSKKAELETLNATWEQLVEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5J3</accession>
    <name>A0A654E5J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_50094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043772">
        <property type="entry name" value="MBG_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18887">
        <property type="entry name" value="MBG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024910290" evidence="2">
        <location>
            <begin position="20"/>
            <end position="2616"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="474"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="1558"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="1658"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="1758"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="1857"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="1956"/>
            <end position="2052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2616" mass="278714" checksum="33895CB1E0129AEE" modified="2020-04-22" version="1">MNKSLYTFLLIFISHWAVAQLTVTGLVPGQNANYAAIDANIEITFSAAVDATTLAGNILVKSDLQGGLPFTVTGGGTAVITIDPNDSFLYGDKIHVLLKSGIQSVSAAPLTNGFGYSFRVKTLPSYSASPTLKPQKLSTYYAGEKDLSVADMDNDGEMDLLSLGGGSLFWYKNDGSESFSTYTPSVNELANIGGGNSFDMHLDDLDYDGDVDVIYEELAMDLFKWLENDAASFTEHDVTTEADGPNVLASGDLNNDGLVDIAYTSNNGLQLAFNNGSGEFTLVDIEGEQSNGKLVGLADMDKDGDIDLVCQGTSSRCFWYENDGSGNMTQHLLGSSVSSLSYIDPVDLDDDGDMDVVISSNFNDEYYWFENNGSQTFSKHLLSNSADGVHLIKAGDLDGDGDMDILTTYSNDAQVVWLENDGSENFTERVLADNFNSVKFMNPVDLNLDGRMDLVVYQSDGIYWFENKVNEDPTLENPISDESAQAYISFTYTFPSDVFSDPDLMILNYSATLGTGDPLPGWLSFDADLRTFSGTPGGSDAGTISVKVTATDPAGASVSDEFDLEITVPSLMTLDSYAPEHYEQNVSAGANLTFTFSGNIDNTTLTPANIKVRGSMSGLIAGSFSGGGTPTIQFLPGNDFLPGERIHVMITTDLKSEGGGIIAGNKSYYFDVEAALPPSTPALLVSENEYNIDSTPTDMVEVDLDKDGDLDVLTSSRPYQRINWHVNDGAGNFTVTYINHSGVTSCKIDVADIDQDGDNDIVVFANSGGAWTWLENDGSQVFTSHVMSAAMNYTMSVSIVDLNQDGSLDVLATESGSDNVLWFKNDGAQNFTQLEIGTFGTNPNKAYAEDLDQDGDIDVVVGGHNYGTNFLAWYENDGSQGFTYNEITQTADGVSDVDVADVDGDGDMDILTAENREDHVVIYQNNGNQSFTALEVSDDITGPVQACFVDLDADDDLDIVIGADGVNAVGWLENKGGFNFTYWELAANEGNLIGFGDLDGDSDLDLVSVSEGTNKLYWYQNKANETPVVSSPKSDEEVVAGVAFSIDMSGVFSDPDGSNTLVHSMTMTNGNALPDYLTFNSENNTLTGTAPYGADGTYSLRLIATDHAGEAAFDDFDFTVSEPPLISVVSFTPLRGSYQSTDAGISITFDKNVDATTLPGSLMLYDDQGQVVSGDLGGGGTATITFTPAFDLAQNHEYTVVLSDQLEAEDGSIRTSPFSFYFKTSASPAPGAFVKQSTLVSHSFPLGLDLGDLDGDDDLDITVPGGTAATANLLVSAGADAGVTKDLGVHASSILIFDLDQDGDLDVISATTIDDKITLNKNDGDGNFTITDIVPGITDPEAFRIKDMDMDGDFDLIVVSHLSVDIYQNNGSLTFTKLHVSDDDHTALEVLDYDLDGDLDILGGENVWYENDGLLSFISHSGIFFDDLEMDDIDGDGDQDIVVSHANNLTLYNNDGTGSYITETLLSGQGTGVLKVVDLNGDGHLDVVTSFRSDNALFFLENDGSGAFTSALLSDQESDVIDFEVGDLNGDGNLDIIVCNYGDNEVTWFKNRSNADPTVDNAMANQETNEDALFTFSIPENTFADADEDELSLSASLTDESALPDWLSFDPASHTFSGTPLQANVGTISIRVTADDGLEGIVSDDFDITVNNVNDAPVVNQSISTKTALTDLTFSFEVPTNTFEDEDEDVLTLTAGLSDGSALPDWLSFDGSTKTFDGTPTVSDVANHTIRVTATDPSTSSVYTDFTLKVTLDNDPPVVAAPVPDLEASEDQPFQYSFAANTFTDPDDDLLTYGMTLQGGDPLPSWLTFEATDFELSGTPLQSDVSTYTIVLTAADEFAEVSDEFVLTVNEVNDAPFLVAGLPDHSVDVGEDISIVISESAFSDEDHAELIFSIRMEDGSDLPSWLTFDAASRTLSGTSSQENVGQYSLRVTASDGEESASDVFVLTVISTNSSPVVRSSLSLLRLDIGDTLTLAMSTLFEDPNGDDLSFESQLFGGAELPDWIVLEEDTLTISPTVGTLGEYTVEIIASDPFDESVSMTFDLEVSKSDQTISFTQIASEVNIGAESIPLEATASSGLEVVFSSSNTDVAMVEGGFLEIIGAGSAIITASQPGDESYNATTSQQTITVSKYSQSITFELLSEKTYGDGSFDLEAYASSGLEITYESSDETVATISGKVVTIIGAGNTTITASQPGDEEFDVASDVAQVLTVNRAPQLITFEAIGEKAANEKPFDLIATSSSDLEVSFSSSDETVATISGNTVSILSSGTTTITATQAGNANYLPASEEQILSVSDVTKLDQTITFVGPDDRVFGDAPFELSATATSGLVVSFESSDESVATVSGSTVTIVGAGTTTITATQNGDQDYLSAESVGQPFEVSTAELVVTPDDQEVVYGEALPEFTYSISGFVNGEDEQALLVQPQAGAGLSGIPDAGVYEITSSGGEAANYSFVYTEGVLTIHKAMASIVLTDLEHEEDGTGKRPEVTTEPADLNFVMTFNGDAEEPVTAGSYEVIVEIIETNYTGSATETLVITSEQVLSAPSPVRVNVYPNPASSHILVKTPEVTICKLYELDGGLVQEGKSNEPMDISRVEAGIYILQILSEGKVIDQVKVIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5J6</accession>
    <name>A0A654E5J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase-like lactoylglutathione lyase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="353" mass="39393" checksum="ECF2E0A2495B7212" modified="2020-04-22" version="1">MYKRINGIQHIGVGVSDSEVSQKWYRKFIGMDIPIFDGVAPAPLMDVYTKNETITKRATMILNLQGGCAMEVVNPTSFTPRQPDFETQLGDIGIYINQIKAFDVEAAYAHFEKHGAILRSGIVDMPDGGKTFYVEDPNGLLFQILPGRNFYTKGHHITGGPNGCVIGVSNIDNSLKLYADVLGYDQVVYDETRVFDDFKSLPGGEKSFRRIRLTQSNPPGGGFAKVSADTYIELIQAQDYQPRKIYKGRIWGDIGFVHVGLDVRGMKALGEELATKGFGFTCDTRDTLDMGGTTRVHCTYIDDPDGVLIEMIEVYKIPIIEKLGVFLNVEKRDPLKPLPDFMLKALKFSRIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5X4</accession>
    <name>A0A654E5X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="344" mass="39081" checksum="F265090D90FD1CEB" modified="2020-04-22" version="1">MKQTKNILRVAFILASIGSLYFVPWILVKAWILPLPDTVQEQLEEGIGYGFDGMIAYVDQGGKPPEYYAAGWHDRKNKIPAYPQALFKIASITKLYVAVAVAKLVKAERLSLDKTLAEYFPELVGRIEYADRITLRMMVQHRSGIPNFVDHPDFWTKPPKNKQETLEYALDLPADFEPGEDYGYSNTNYMLISDLIDQVVGYPHQQYIKEEILIPLGLKNTFGSLSEVNIDDVMSGYYVGVEEDFKTENTGLMLATAEDVGIFIRALNEGSVFNEGEQDIYSSIYEYEHTGLLVGYQSIAKYHKDIDTVVIQFNNTTNFDGYNWNLAEIFYGRIVKIVRRANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E647</accession>
    <name>A0A654E647_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ORF">MARINOS108_90085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5029054850" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029054849" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="189"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="407" mass="44547" checksum="FA06ED85F45FDF5A" modified="2020-04-22" version="1">MNMIRNITNVRGIKCWGAHTGVKSMRRDLAIMYSEVPAKVSAVFTQNLVIAEPIKLTKKHLQESNYMAQAIIVNSGNANAVTGQQGAEGALAMAQTAADEFKIDVNQVMIASTGIIGQKFPTEEVVDGIKENVKKISENSRAGSFAANAILTTDTFAKEGYVEFDIDGNTINIGGIAKGSGMIHPNMATMLAFAFTDINIDQKLLDKAFKEVVEDSFNMITVDGDTSTNDMASIMANGLADNEMITSASDPHYITFKEKLNELMVHLAKLIISDGEGASKFIEYRLSGAKTREDARKIVRVVSDSSLVKTAMFGRDPNWGRILAAMGRSGVSFDVDKVDLSLGNEKEEVMMMVQGKPQEFDINLVKRILKQSEITIKMKLREGRSSAIGWGTDLTTDYVMFNSMYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6H7</accession>
    <name>A0A654E6H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="227" mass="26064" checksum="EB74038FA4053074" modified="2020-04-22" version="1">MNIILSFLISFTTCVQLDFDWVSFSMVKRSTTHGMVSRIDARVFYKPSGKMVTHFISPIDMYVLNNSLGNVEIFNTKENTVVKSLDNRMGSRNTTFYYFLFGSSEDLGLSEAGFSLRESRIEDMMLVTEYTPPAAMGGLEKVELVSNGDHPVFMGYLDKDGKYLKKTYYYDYRMVRGVDFPMSITEIDFQKNDSTITKTTFSDFRFNVPEDQEFADFKTPNTATLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6V2</accession>
    <name>A0A654E6V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="155"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="32528" checksum="66362C7115F8C6A3" modified="2020-04-22" version="1">MLPKKSLGVILAITGILLFSSKAVMVKLAYQYEVDTVSLLLFRMVFSLPIYVVIAAFNRPKEKVAGKDYMWLILFGFIGYYLASYFDFLGLIYIKASLERLILFIYPTLVLLISFVFLRKKITRKQVIGVVVTYLGVLIIFVSELSISDDSSVILGSVLIFLSALTYASYLVGSGWLIPKFGATAFTSYAMIVSCMAVILHYSLQRPVGLLDFQPEVYWIGLAMAIFATVIPSYLVSFAIKILGANDFSIFGSLGPISTIGLAYLFLGETLTWTQFLGAGVIIGGIVLAEKKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8E2</accession>
    <name>A0A654E8E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024985217" evidence="2">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="376" mass="40687" checksum="7231084D42CE6EB7" modified="2020-04-22" version="1">MKVLFYSILLACSTSSVIAQQVDVQYLNPKHYSTGVYKFIRIGTSSDYGAGLMLNESSADYGDGNDFSLFTYNDRDLTIKTGLGNFIVFPSSGGNMGVGMTNPISKLDVLENSGSDVVARFRTGEGRISIGAAGPSTANYTYGNYISSHNFDGTSYKDLGLKTAAGPPQFVFTTSGNMAVGISSPGTYRLAIKQSSSNSGYGLRILNAAQNRSAQLWVGTGGAVLDAEGGANLHLRTAGIDRIYIKNNGQIGMGTSATGSHKLAVEGSIGAREIKVESSGWSDFVFEKDYKLRPLEELESYVSEHQHLPEIPSEAEVTAHGINLGEMNAKLLQKIEELTLYLIEQNKEIRAHHEQNKSLEMRIKELEKQVSQIGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8I5</accession>
    <name>A0A654E8I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydroorotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="418" mass="45688" checksum="426C561550C22A0D" modified="2020-04-22" version="1">MKTLLANAQIMDVHSKYHGETLDILVEDGIISAVGKGLEGKKVIDLEGKVVTPAFFDFFAHFNEPGLEHKENLTSGIKSALFGGFSDVCLIPNTHPVIDSKSDVGFIRGRSTAGVELHVIAAVSEGCLGENLTEILDLEDAGAVAFSDGLSPIWNTELLLKALQYVQKFDGLIINRPKDVHLSQFTHMHEGAMSTSLGLKGEPGISEEIAIKRDLDILKYAGGRLHFSHLSTARGVELIKAAKKKGLQVTADVAVHQLLYTEEDLIDYDSNLKSDPPFRSERDRKALIKGLKEGIIDAIISSHQPQDPESKELEFDLASPGLMSLPTVYSDLLALQDELPLEIAVQRLTSGPRAILGLPEVKVEEGSTAKLAVFDPYQVWEFSAKHNPSRSNNAPKYGKQLTGKCFGVYNQGTFFQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E997</accession>
    <name>A0A654E997_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="28555" checksum="96CD5DE205459F0F" modified="2020-04-22" version="1">MLKIGISACFLYPDPQRSVFGPKTLSYLENDMARYLTKEGVIPVLIPDVEDKLLLPLVEEMDGFIFQGGTDLAPESYGEKPIENGRWKGDPVRDKYELKLMNLAMESDKPILGICRGMQLMNVYFGGTLYQDTKTQRPEVLVHRDAEQYDTVSHEISFTEKKILSKIYKNAQSTRVNSVHHQSIKNLGKNLEVLAESPEDGVIEAIGYTKAPDGWVMGVQWHPEFSHTLGSQVINADKLYLYFLEHVKSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA20</accession>
    <name>A0A654EA20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA1(Val) (Adenine(37)-N6)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.223</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.223" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTS" evidence="3">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="24136" checksum="82A22F7B7ED20341" modified="2020-04-22" version="1">MKVTTEGCLFGAWVGTVCKAPRTVLDVGTGTGLLSLMLAQANSTAQIDAVEVDGPAATEAQANFEACPWHERIQMIITDVQSFTNSQRYDLIIVNPPFYSQSQRSDSKSINRARHDAELSQPDLIDALCRLLHEEGEAFVLYPVREAKQFADLAMGSGLFLQRALQVYDSPGALPFRVMGQYAYQKVDPVVEDFYIKTGDGGYTSGFVKLLRDFYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAQ7</accession>
    <name>A0A654EAQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024814493" evidence="2">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="449" mass="50807" checksum="733D5362894059D6" modified="2020-04-22" version="1">MRKTLIFMMITMSVLAHAQDTEEVTVLTLDDCIQTALERNIQLKQARNSQLMAESNRLQSIMNFFPSISAGVNYDYFFGNFFDPNAARQVSETTSSSAPNISSSMVLFNGFSNHFQLSQRKHELVAASETIKNTEINVESNILAYYLSVILDKENIKIARERVELLEAQLEREKKRESVGVGNLESVYNFQGQLANQKLTLNNLENTLRRDLLTLFQSMQLNPNDGEVEVQAYDVQEDELLLEADPFEVVLEETLSSSPALKAASSSYEASRYQFKSAKAQLYPTITAFGRIGSNYSSNGARNPTNGDFEPDASFSRQMEFNEFEYVNFSLNIPIFSRYQTSNSIQIAKVGMANAELGVSQAMNTITNLVQTAYLDLVSAQNTYISAKENLAATTQTFEFMKKRFETGNTDFYTYLESLNNKNRAELELINSKYSIVFRKKILELYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBF8</accession>
    <name>A0A654EBF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4418" checksum="3BEFC7EE8F45B117" modified="2020-04-22" version="1">MNHALGDLQSNGLAGFFLKDTKKGDPSRVTFHLLAANFLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBJ3</accession>
    <name>A0A654EBJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenoprotein W-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="78" mass="9045" checksum="504EDF2E515A46A2" modified="2020-04-22" version="1">MMRAHWMSQELLTTFSEELDEVTLRQGTGGIFDIYANETMIFSRKEMGRFPEITELKQLVRDHIAPDKSLGHSDKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECK3</accession>
    <name>A0A654ECK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulatory protein RprY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rprY</name>
        <name evidence="6" type="ORF">MARINOS108_20407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="26382" checksum="E62F92299A9F1F11" modified="2020-04-22" version="1">METPKILLAEDDENLGQILSEYLNLKGFKTTLCRDGEEGAAIFKPGSFDLCILDLMMPKKDGFQLAAEIKEIDPEIPIIFLTAKSMKEDILEGFKIGADDYITKPFSMEVLLMRIKAVLHRTLKSNADRELPEEVTVGALRYQYASNMLHLPSGAVKLTTKENELMKLFLENLNQTVTRTVALKRIWKDDSYFNARSMDVYITKLRKYLKEEDSLKLLTVHGEGFKMVHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECS6</accession>
    <name>A0A654ECS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="5686" checksum="7B388A89D047A214" modified="2020-04-22" version="1">MFFCDYDSKIKKLLTFLQYFAYFLLITQSHKRFVRNYPKRHHQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFU2</accession>
    <name>A0A654EFU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">cobB</name>
        <name evidence="5" type="ORF">MARINOS108_90171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="25805" checksum="03E765A04F2FFA8E" modified="2020-04-22" version="1">MKKIVVLSGAGISAESGISTFRDSGGLWEGHNIEDVATPEGWGRNPELVLDFYNQRRKQALFAKPNIGHTVLAQLEQDFHVTIITQNVDSLHERAGSSHVIHLHGELSKVRSTIDESLIYELDGWELNLGDLCGKGSQLRPHIVWFGEAVPMMDLAIKHTQEADFFIVVGTSLVVYPAAGLLSFVDNHIPKYIIDPNLPALDHVPNLHYFPKSATEGLAIVCDIIRSNNLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSF9</accession>
    <name>A0A654DSF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="79" mass="8945" checksum="22393256DDD49129" modified="2020-04-22" version="1">MKKLLESNQLLRTSGLLSLTLGLAPFVPEPHVWGKVQWVLGGAAGMQPMDYFDLLLHGTPWLLFFTLLIYRGFRYLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTA4</accession>
    <name>A0A654DTA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="17372" checksum="F34EDB8CA0DDD2BE" modified="2020-04-22" version="1">MTTLFRTNAQHADFIELVSQLDADLAVRDGRDHAFYHQFNQIDQIKYAVVAYLDDQPCGCGAIKQLDPKTMEVKRMFVKPQHRGKKMAFQILNELEQWAAELGFDRCVLETGYKQPEAISLYEKSGYQIIPNYGQYAGIANSVCFEKRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTM3</accession>
    <name>A0A654DTM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="386" mass="42941" checksum="C197FA8369AFDA08" modified="2020-04-22" version="1">MVKQFLIPIFLLFFLSCETKSQENVQILPGASQLDQYLPQLKGKKIGLFANHTSLVGQTHLADTLLSLGIQISTAFSPEHGFLGNKPDGEKIEGEYTERFKLISLYGAHRKPTPEQVASLDLLVVDIQDVGARFYTYASTMTYLMEACAREKVPVLILDRPNPNGSYIDGPVLDIAFTSFVGAHPIPIVHGLTLGELAGMINGEGWLGNGLQCDLSIIPVANWDHSMPYTLPVRPSPNLPNELAVALYPSLALFEGTVVSVGRGTDFPFQIIGHPLYSDSSFSFTPTPNEGSKYPPLEGERCFGLDLTHQPINYGFTLKYLIQFYQDLKGKTENSFFNDYFLKLAGTGSLQEQIEAGWSEQEIKASWEKDLEAYRKLRKNYLLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTM7</accession>
    <name>A0A654DTM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine biosynthesis bifunctional protein HisB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Histidinol-phosphatase</fullName>
                <ecNumber evidence="8">3.1.3.15</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Imidazoleglycerol-phosphate dehydratase</fullName>
                <shortName evidence="8">IGPD</shortName>
                <ecNumber evidence="8">4.2.1.19</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">hisB</name>
        <name evidence="9" type="ORF">MARINOS108_10388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the histidinol-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="8"/>
    <dbReference type="EC" id="4.2.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01022">
        <property type="entry name" value="Bifunc_HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020566">
        <property type="entry name" value="His_synth_bifunc_HisB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005954">
        <property type="entry name" value="HisB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01261">
        <property type="entry name" value="hisB_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Histidinol-phosphatase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Imidazoleglycerol-phosphate dehydratase" evidence="8">
        <location>
            <begin position="173"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="41021" checksum="AE4DFB5DB62B07AF" modified="2020-04-22" version="1">MRPILFIDRDGTINAETADEQIDHIDKLNFLPDVFFYLRKIQAESNYVLAMVTNQDGLGTDAFPEDTFWPVHNLIMRTLESEGIKFDSVHIDEHFPKDNHPNRKPGTGMLTQYQDGTFDLKNSYVLGDRATDVQLARNLGCKAIHIAEEAVTDAELTTASWKEIYEYLILHPRKASVQRTTKETDIAIAVNLDGAGNTSIETGLGFFDHMLDQLGKHGGIDLTVKVKGDLHIDEHHTIEDTALALGECFLKALGDKKGINRYGFLLPMDDVLAQVAIDFGGRPWLVWEPEFKREKIGEMPTEMFMHFFKSFSDTAKCNLNIKAEGDNEHHKIEGIFKAWAKAIKMAIKRNPDEMSSLPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTQ2</accession>
    <name>A0A654DTQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043726">
        <property type="entry name" value="DUF5668"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18917">
        <property type="entry name" value="DUF5668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5668" evidence="3">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="126"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="25866" checksum="BDC926C13F963443" modified="2020-04-22" version="1">MRNQENRNQRAWLGVAFVTFGAYLLFRNLDLIPEFIPHYLFGWEMIFLVIGGSMIVTGRREGLIFFFIGGFFLLPEFFYWPQFNLRTWWPAILIAVGVSIILRRRDHVKRAPGDLTDDYIEDTSIFGGSEKSFSSQNFKGGKITSVFGGSEINFSGAKMHGDEIILDIFCLFGGNGLIVPNDWTVINESFVIFGGFADKRPKVSYEPGAPKKVLRIKGSVIFGGAEVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTQ7</accession>
    <name>A0A654DTQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F420_oxidored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="62" mass="6324" checksum="722E596CECF5A3CB" modified="2020-04-22" version="1">MKASKLNIGVIGAGQIGGTLIKQYTKAGHAVKMTNASGLDKLKHLACETGAHAGSLKTSSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTR3</accession>
    <name>A0A654DTR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metalloprotease with PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025050550" evidence="1">
        <location>
            <begin position="20"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="482"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="616" mass="69398" checksum="9BD852E901FB10CE" modified="2020-04-22" version="1">MKKSVIAALMLLTLSWSYAQSEKYKVEIDLTATANDQVPVTIYTPSSDAEYLEYHMAKVVPGTYSISDFGRFVSDFKAFDKEGNSLQVDTLSINRWKIANGGQLHKITYLVDDTWDKFDGYGDNIVFEPGGTNINAEEKVFVLNTFGFIGYLDGLKFSPYEVSITHGENTFGATALRKKTVNATEDLFFADDFNFLADGPIMYSVPDTISRKIANANVLVSVFSPNKALSAAEVMDKIYDLMEAQSKYLGGQLPVDRYAYLIYLNDDGTLSGAMGALEHSYSSVYSLPEAGADRIGQTVRDVAAHEFFHIVTPLNIHSKEIGEFNYIEPEMSKHLWLYEGVTEYSSMHVQVKYNLYGPETFMEEIQDKLRTADRFPNVSFTEMSERILEPEFERMYTNVYYKGALIGMCLDLYLIKYSDGEKDLQWLMRELAKKYGMQVSFEDDELFGVIEALTYPEVGEFLRTYVSGDTPLPIAEVLSWAGIEYIAEKPGSEITFGDIGITLTEEREIMVDDLSEANAFAKDLGYQVGDVITEFNGQAFELSAVRKIISDFKANTTPGTKVTVVVKREKNGKVKSKKLKAKALQIETMDQHFLEFVEEPTESQYKVLQSWIVAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU02</accession>
    <name>A0A654DU02_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5689 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043744">
        <property type="entry name" value="DUF5689"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18942">
        <property type="entry name" value="DUF5689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5689" evidence="1">
        <location>
            <begin position="281"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="51741" checksum="A71E21E740BC2137" modified="2020-04-22" version="1">MFSKFSTFLTLVLGIGVLGCVDENELEPGLEPVSKTSIDFVDKDLFIESAGDSLPLGISLDQMPTTDGQVSIQLGGTARYGLDYTTNPSAEDGVIELPILKGKQFYEVAVYRSSTLDTTDRQVSLTLLNPSEAFQLGTEKVSNMHLVKSLSEEPNNSEGAEVNFADSFVHLVEGEDYLIELTIEGSVEHTVPLTISIVTDGRVYGTHFTTSPASVLGEIDLEVNPGMESVFFSFNSINDRLSLGTFEILFQINDLNDDLTVGNNPTLTVKIEEDDVVSNELHSIAELRAKFEEHGDQFWLGDDYFIKGVITSGSNVQDDKIAYIQDSTGGIFLRFSSERMVTLGDHVQLNLKGATGALINGQKGMMDVNDLVGIKIAEKVYVQPETITFEDLHSGLYQGKKVRIDNVFFPQANGVRTFEGSWAISNDHSGATVTTYSGAEFSGVVLPNGTLSIIGIVGDWGRILPQTYAQDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUB1</accession>
    <name>A0A654DUB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025055912" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="18373" checksum="2CE87410D20EFC67" modified="2020-04-22" version="1">MMKKAVTMMLFLLAGVVGWAQEDTFTNEELTTYASVMVWAENEKAALSSVVSDSVAIWLENTDLTNAQYNELSKADKKGELESVEATEAQVAVYTAIRNRIDDKAAKFKERYVSRIKDDIGAGLYNKVKTALKKDEAVKARYYEIYAQLQTESSEQEESSGDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ6</accession>
    <name>A0A654DUJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="22304" checksum="FC8CB5BEA5AA200B" modified="2020-04-22" version="1">MKLTNLELILYFTTYMDDIQFWLYLAFAAIYFITRMMKKKNAPEPTQSAEEESEHPERRTRPVSFEDLLKEFTEGKQEPEPEAPQPVEARQLVKEREWVAQQKPKEFEEGRTRRFADEESRRVYEESIRLAEGSDLEFKRDEHFKSKMQRQQDEGDQQSLGADIKSMLQDADSAKKAVILSEILNRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN5</accession>
    <name>A0A654DUN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="22330" checksum="4CF506C91639159C" modified="2020-04-22" version="1">MLTPLQKKKLLHYFNVLDFDKSGTLEKADFLNIGENLSILWGFKEGTPEYEASIDRCRGTWAGFRNFIGKSDESHATIEEWIQFADQIVVNGDEELYEKHVNKVMREIFNLFDLDGDGYISLNEYIDLFMAYRIEIRYSARAFTKLDLNQDDLISRDELLSGIKEFFRSDDREAAGNWLFGFWETYLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS5</accession>
    <name>A0A654DUS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041342">
        <property type="entry name" value="DUF5010_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18099">
        <property type="entry name" value="DUF5010_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="785"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1112" mass="117445" checksum="CB8E3319C09DD262" modified="2020-04-22" version="1">MTPITISNQYIRPLLVLILLLSGLLLAKAQVGNVLWEDNFDTFNTDIWTPNVGDGCPGLCGWGNAELEYYHGNNVSIEAIPGESGNNALVLEARNESMGSQSFTSGKVDTEGKLSIHYGLIEVRMRVPNLETGLWPAAWLLGTVNQAWPAKGEIDMMEMGHKAEERTRQGYPGVSSNNFVGANAIFQTEDGGYGSIAYDVDYNQPYVPANALSNRFVTYRLYWEPTQMRFAVEDNGTEYDLYTNPLPLDPDGVTAAFTRPFFMLLNLAVGGNFTDAANSGAVTAPIPAKMYIDYVRVSEWNGHGEVAFDYGALSPEAGTFGVYTDDTPTNNELVFGSDAAIYAWGGTVQEGTTPAYEGSNVIAWETTTANSWFGGGVTSLYGKNMSGFVENGSMKFRIKIPANVSFRIGITDNYTNEQYINFPAGVNQYGLVRNGEWGQVEIPLEDFTGLVAFQNLGYLFAITSLDGSLPASTFQFAIDDIYWTDGNGSNVPVTGVSVSPGTASLEPGETQQLTATVTPSGATNPGVSWSTNNAAVATVNSSGLVTAQSAGNATITVTTADGGYTASSNITVTNRAGGLPSPWQSQDIGAVAATGSASYSSGTFTVNGSGSDIWGTTDEFHYVYQSLTGDGAITAQVNSMTNTDVWAKAGVMIRESLAGNSKHALTAITPTGTSAFQRRTATGGSSSHTGGPTANAPYWVKLERAGDTFTSSVSANGSIWTTVGTATISMGSSVYAGLITTSHNDGTLCAATMSNVSLTTGNPVTYAPLPGIVQSEDYKEGGEGVGYHDTSAGNTGGGYRTDDVDIEATGDTGGGFNIGWVDAGEWLEYDVTSTVASYELSVRVASPSGAGRLHIEVDGINVTGTIAVPNTGSWQSYTTVTVPGIAISPGNHSLRVVFDAAGLNLNYVEAVKETSTPSGCTQSGPNGDYTVDISEDASNPSLTFIPGPAGTGTPTTILYYGTDPNGTYPGYGVSPNSPYTINAANGQTIYFYYTYSVPEGGERNSSTNRHSFVVGNCSGSGARVASTPADLVINSDLTVFPNPVKDIVTLKTEAKGYDRIQVLDISGRVRRDLKISGNHDEFQINLNGLSAGNYFIRISGASETKVRRIIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS8</accession>
    <name>A0A654DUS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="21549" checksum="73F237B362A4950A" modified="2020-04-22" version="1">MKKYLNDAELIAGCTKKSQKYQELLFKKYYGYAMSIGISYLNNRDDVVEVVQDSFLKVFNAIDQYQPSQPFKYWLRKIVVNTAIDYYRKQRKFHLHVDISDAIMESPSPSYCVLDKLGTQDLIDIINKLPLTQKLVFNLFEVEGYSHAEIAERMGFPESSSRTYLTRAKKKLRELVMQYENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV0</accession>
    <name>A0A654DUV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="15041" checksum="CDF42C0DD67CC528" modified="2020-04-22" version="1">MRDFIDHGNYQDILFDLSILKGRHKLHPIHIWHGHIGDNQIKIFLFKFLEGFLSIIGFIQNLYFFICRKVLPDGVPDHGMIIYQKDPNLVFHVAVTLYINDPAISWVQFCHQSNAISQTFDPNKLLIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX5</accession>
    <name>A0A654DUX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antidote protein, HigA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="11521" checksum="0B2E17D21FC73E40" modified="2020-04-22" version="1">MVPGSAMHPGELLKDELEAREMKQIELAKELGIAKNVMSEIIGGKRNITPELAVRLEDALGIKAEFWMKYQVAYEIDKIRIKNKKAVEKANIPAKTKAQMASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV57</accession>
    <name>A0A654DV57_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ORF">MARINOS108_10554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="148"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="30184" checksum="CD8DA1208CD671DE" modified="2020-04-22" version="1">MASWTHFYLIRIQFLGHNYHGWQKQPSLPSIHGAIDDTLKVILKSAPFKTLGCSRTDAKVSAEDYVLELFLNKAIVPEQLLHQLSKHLPADISARSVAPTHQGFNIIQGARSKTYHYYFSFGRKPHPFSSPLIHHVRQDLDIDKMKLAARKFEGNHYFGRYTQKPSAETELQREILSAQIIPNEYVTGSFIPQDSFAFSVKAHGFIRYQVRMMMSALFETGRGLWSMDDLDQSLSMETDHTHKVMHVAPPSGLVLHKVNMDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVH4</accession>
    <name>A0A654DVH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug efflux pump subunit AcrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119299" checksum="3E6ADE7E1B0B18C9" modified="2020-04-22" version="1">MSTIKGLVAYFVKYPILANILIALTLFGGVVSFLNTKKSFFPTAKDRVINIAVTYPGASPEEMEEGVTTKIEEALKSTAGIDEITSTSSENSASISILTFDNYDIDEVYTEVKNAVDGISSFPVGAEKPIVYKQRQRSTAQWLGLTGDVSLKTLKEYAEGIEDDLLATGVISQINVSGFPPLEISIEVSEETLRRYNLTFDQVASAVRLNNRDISAGSIKSANEEILIRSKAKETEADQISEIVVRSNTDGSKLLLRDIATIKEQFADEPSKALLNGKQAVFLEVRKLEAEDLTEISEAVDAYVKDFNAKNDAVQLTTTWDFNNMLTQRLDLLTSNGLVGLLLVLLSLGLFLSIRLSFWVAWGIPSSFLGMFILGTFVGLTVNMISLFGMILVIGILVDDGIVIAENIYAHFEKSKNPIQAAVRGTLEVLPAVFTSVVTTIVAFLPLLFLTGGFEFLKDMAYVVIFSLSFSLLEAFFILPAHLASKKVLSVKKEDTRSYKIRKVLNNGIDFMRYKVYGRMLSYSMKYRMVSMAVLLGFLIVVSGLLAGGQIKATFFPQIPFNSFNVNISFKPGEREQKVESYLTRFNDAIWKVNDDLKKEFETEKEIITYTFTNVGFSGDGESGSHAGNVNVMYEELDEYGINQFDLINKIRKEIGPVPEAEKFSIGGGNRWGKPVSIMLLGKNYTELKEAKDFLKAELENISDLKEIQDNVPVGRREMLFDLRPEAYFLGLTHDDITRQMRQGFFGEEVQRFMKGNDELRVWVRYPNSGRESISQLEDLKIKTASGQEFPLTQVADYRIERGVSGIKHFNSSRAVTVEADLQDPFAEVPPIIKRIEDTIVPQLKAKFPSVSIDYGGQSKESARAGAEIGLFFGGAFLLIFFILMITFRSFYQALLVVIMIPLGWFGAMFGHGVESWVSGRELPVSLLSVWGMVALSGVIINDAVVFLSKFNSLVKDDGLTVYQAAYEAGIARFRAIMLTSLTTVLGLYPLIKETSFQAQFLIPMAISVAYGVLIGTFIILLFFPVLILIFNDFRRALRWLWTGEKPSREDVERVLLDEKRLEEYKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX6</accession>
    <name>A0A654DVX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="245"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="35740" checksum="76980271D72276FF" modified="2020-04-22" version="1">MEEVLSKYFSGEASDEEIKSVHEWRSATENNSKEFLEFKKIWLASQPIEEGNPAMLNSILADEESAPKIIPIWNQKIFRIAAAIIVALGLVFALYPKKADNHYGQVVATVTPFELPDGTIATLQRGASITIGDFKDKREVFLTGKAFFEVERNENKPFIVNTTNVLVEVLGTSFVVDAREERNAVEVMVSSGSVAMAQNPEVFGRRAMKINLEKGEMGIIQVGERGIKKRKITDDNFLSWKTRVITFKSTSLNEVSKTMNEVYGVTFDYENQMLKNCVLTAKFNEKTVDEVVDIIAETFNFTYVKTADKILFTGNSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY3</accession>
    <name>A0A654DVY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035386">
        <property type="entry name" value="Arm-DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17293">
        <property type="entry name" value="Arm-DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="189"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="42221" checksum="01D2B2F4CBC4271F" modified="2020-04-22" version="1">MKVTLRKRNQGGQTSLYLDYYHQGKRKTEYLKLYLDPNAKTKEQKEVNKKTLQLAETIRAQRQIEIQNGVYGFRDNEKLKGSFTAYLELLANKRKDSPGNYGNWDSMIKHMKAFIPQDISFEFVNREFVQDFKEYLDKKATGHGIQKLSQNSKYSYFNKLRAALKQAVKDGIIPHNPAEGVEAFKQGEPEREFLTLEELQAVVKAECEIPQLKTAFIFSCLTGLRWSDINKLLWSEVQHSNDMGYYIRFRQKKTKGAETLPISEQAFGLLGERQDKDERVFKGLKYSAWHNLKLQQWVMRAGITKTITFHCARHTYATLQLTAGTDIYTVSKLLGHRELKTTQVYAKIIDDKKKEAANKIKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ2</accession>
    <name>A0A654DVZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="33724" checksum="89820AA103EC0532" modified="2020-04-22" version="1">MKDILKKLRKYEIRVRKAINSQMQGDFHSIFKGSGLEFDDVRAYQYGDDVRTIDWNVTAKGHGTFVKTFIEEKEQTVLFMLDVSASGEIGKANHQKIDLGKEITALLTMSAVKESSSVGLLSFSDQKETYIKPGKGMKHSYEILSSIFSLKPISRKTNLDQAIRLALGMLKRRAVIFLISDFIDEDYLHSLKGMARKHDLVVIQLFDKRESNMPSLGIVPLLDKESGKTIWINTSSGKFRNVLDKTYRKNTAALEDFCRRNDVNYLSVETEEDYVPKLVKLFRHRNKMNSQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW36</accession>
    <name>A0A654DW36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024960535" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="17977" checksum="E0D12AD3800E052D" modified="2020-04-22" version="1">MKKIALLVVCLSMFGLANAQISKGEHFLGGTVNISDNDGSGAFVLLPEYRYAIGDRDLLGLSIGYISRSVPDVSYAVFHPNYTRIFPIEGSFFWLLNGYLDLSFGDQERVAPGISPGLGYRVHRSTVVILRSGGISYDFKADYFDLGLNTSNLGMSVYFRIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW74</accession>
    <name>A0A654DW74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="144"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="26235" checksum="67888324FAAA6448" modified="2020-04-22" version="1">MFAGSALASNFSSGQTVENGNRANALSVSQEQIVIISSLTAKGDLLQLRDALSSGLDAGLTINEIKEVIVHLYAYCGFPRSIMGLRTFMTVLDERKEKGIEDTWGNAASPIPDSPDKYTRGVETLEKLTKAKLGPKPAYQEFSPEMDVFLKEHLFADIFERDVLSYHARELVTISVLSTLGGLEPMLRGHFGICLKVGLSSNQLGEALNIIHKHIGEKEALAAQQVLEEVITNHRNDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW80</accession>
    <name>A0A654DW80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="1">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="18225" checksum="9CFF90187F0EBBC8" modified="2020-04-22" version="1">MSNNQYHLAQFNIIKLKDHLASPVVKEFSDFLAPVNQLAEESPGFVWRLKDDLGESAANIETPYEDELIFVNMSVWQDYEYLKAYTYQTVHSYFLKSRKKWSLEIEGHRAVMWYVNEGHVPSLAEAKGKLDLLNESGSSRLAFSMTDVYHSDGARLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG8</accession>
    <name>A0A654DWG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="21528" checksum="AA60385CB6A5F210" modified="2020-04-22" version="1">MRNPETTKNLIVSKAISIFNQKGYRATSLSDITKATGMTKGAIYGNFENKDAVAVASFEYAIGRVLDDLRMHIKAAPTAPEKLKAILNYYSKYIENPPIAGGCPVINTSVEADDDHPMLRTRAVGTIAMIKGSLQQIITRGLQEDQIREGVDAHLYASMFYSTISGAILISRVEGNKQSFELIRQGLEMQINAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT2</accession>
    <name>A0A654DWT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="374" mass="43122" checksum="5D3DDEFB4DB4D01C" modified="2020-04-22" version="1">MPIEIQEITSKKGLKDFVRFQWKLYKGVAPYVPPVMDFELSALSKEKNPAFEHSEGRFWLAYKDGEAVGRVAGIIHGAEAEKEKKIRFGWIDFIDDYDVSKALIDTVQEWGKSEDLEVIHGPLGFTDLDFEGTLISGFNQMATQATLYNYPYYQDHFENMGFEKAVDWTETRIKVPPGIGGDINRAADLIGRRYGMQIKKFKSGKEILKYADQVFELLNESYSHLYGYYPLSEKQIKYFIDQYFGFVVKDMVALVTDKEDRVIGFAVTFPSLSKAFKKAKGSLYPFGFLHVLKAFYFNDTVDFFLVAAKKEYQNKGLHALLWSSLYAAFVKHKIKYVFSGQMLEDNKNVNNLLTKYESAKDEEIRRRCFTKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX4</accession>
    <name>A0A654DWX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="4">
        <location>
            <begin position="97"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="230"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="312" mass="35650" checksum="5ADAEC12B8B46887" modified="2020-04-22" version="1">MKTQTTYIDAGIQDTSRPAERPPKTNWKMEVVKKGLFTLQHIAPEKTSEIIWHYFSKPGKVKFTSAQQELVENTTARKVNYGKHKVVTYQWGDTGPKVLLCHGWRSKAADFRRMIESLVQAGYVVEGIDMTAHGQSEGTHTALPEFRDILKDHYLANGPYEALIGHSLGGLAAGILSSEISPALQPKQLFVLSSPPFVRYFFHDTIRELGYKDSVYEEMCKLVEKNYAQPVEYFDLRDKAEKLQNINVHLIYDHQDHIVPYQRGEELREAFPNAHFVQTKGLGHYKIIAFPEVISYIRGQLDAQREQKKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX74</accession>
    <name>A0A654DX74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="91"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="26419" checksum="A93859338227B4F5" modified="2020-04-22" version="1">MKIFINDIPVSIVSPEELDPAKEFDLVIDGAITKIKPKSLIDDVLITDAAADKVDDLLHVMTDNKLKKVDSITFCSTDKRDVIRYIKKKFKVIEAAGGVVDKGGKILLIYRKDRWDIPKGKLDKGENKRDCAIREVEEETGVKVSIEKKINATWHTYINKEKYVLKKTHWYVMRCLDDSNLTPQAEEGIDEVRWMTLTELRAALYNSYRSIRVVIQEYHKLLKIHDQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB5</accession>
    <name>A0A654DXB5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="240"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1409" mass="159262" checksum="FEC8CDC5475CC3AB" modified="2020-04-22" version="1">MYLIFDTETTGLPRNKTAPLTDFDNWPRLVQLAWQLHDAEGNLVSQGNHVVKPEGFTIPFNAQKVHGISTERALEVGEDLKGVLDKFSADVQRAKVLVGHNIEFDNKIIGAEYLRTDQENLLEAYPNIDTSTDTVEFCQLQGGIGGRLKQPKLIELYTKLFGKPFDDAHDAAYDVDATARAFFECLRRKIIKTFDDTDPSKITYEAPDLEAANFSWAREKRTGRASNEEVAVEDIKGPFCHLHVHSQFSVLQATPNVESIVAKAKAFDMPAVAITDLGNMFGAFKFVRAALNAGVKPIVGCEFFVAEERLKLQFTKDNPDRRFQQVLMAKNKKGYENLVKLSSYAYIEGLYGLYPRVDKELIKKYREGVIATSGGLYGEIPHLILNVGEHQAEEALQWWLDLFGDDFYLEINRHGLDEENHLNDVLIGFARKYNVKMIAANELFYLDEEDSKAHDVLICIKENEKQSTPIGRGRGFRPGLKNSKYYFKGQEEMKAAFTDLPEAIENIAELIGKVEEFKLERDVLLPAFDIPEEFKNPEDEVDGGKRGENAYLRHLTYIGAKKRYKEITEEIKERLDFELATIENTGYPGYFLIVQDFTSKAREMGVAVGPGRGSAAGSAVAYCIGITNVDPIAYDLLFERFLNPDRVSLPDIDIDFDNEGREKVIDYVVKKYGFTQVAQIITYGTMAPKSAIRDAGRVMELPLPETDSIAKLVPEKPGAKFSKIWGEVPELERMRRGKDLPSQVLNQAVILEGSLRNTGVHACGIIITPDDMTNFVPLAKSKDSSLLVTQFDNSVVESAGMLKMDFLGLKTLSIIKTAIENVKKRHGIVIDIDEIPLDDPKTYELYQKGETNGTFQFESPGMQKHLRALKPDKLEDLIAMNALYRPGPMEYIPEFIDRKHGRSKIQYDVPDMEEYLAETYGITVYQEQVMLLSQKLAGFTKGEADVLRKAMGKKQKQVLDKMKPQFIGQAKEKGHPEDKLEKIWKDWEAFAAYAFNKSHSTCYSVVAYQTGYLKANYPAEYMASVLTHNQSNIEKVSFFMEECRNQGIKVLGPHVNESGLNFEVNAAGEIRFGLGAIKGTGESAVLAIIEERDANGPFSDLFDFASRVNLRAVNKKSFESLAKAGGFDCFDEFHRRQYVEPDEEGASLIEKAIRYANKLQQEEDSAQASLFGGGSESNVVMRPRIGKIEPYGEIEKLNIEQEMVGLYISGHPLDQYKFEMKYFTNTKLSDLVDLEKLQGKEIKLGGMITEVAHLTTKKGKPYGRFKITGYSDSHEFFLFSPSYLDFKAYLEKGWFIYMTGIVQNRWSGTDLEFKITSMEPLSDIRERMAKGIELQMRLSDVSPALIGELERYGQKYPGNNVFKLNIMGAFEERMINLEMMSRKISVDINDDLIKELDRLEDISYRVLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD1</accession>
    <name>A0A654DXD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="119"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="20738" checksum="8A5D345E42C694A3" modified="2020-04-22" version="1">MKEILDFVSQPWPWYVAGPLIALVMFTLIIFGNNFGISANLRTVCSIVGAGKNCEFFDFNWKSQLWNLVFAFGLVLGGLITHQYLTTPDEVTLSAATLADLAELGIEAPRDQLVPLSIFSWESLATVRGFIILVVGGFLIGFGTRYAGGCTSGHAISGLSDLQLPSLIAVVGFFIGGLFMTYLVLPYLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX3</accession>
    <name>A0A654DXX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="13810" checksum="0C0BB696B6A6384B" modified="2020-04-22" version="1">MIEWVDVFTREDYVFTREDYVWIVLDSLKYCQEKKGLIIHAWVIMSNHLHLIISRELEGSTFSDIVRDFKKFTSSSTVDSIESNIQESRKNWMMWIFRSAGQRNRNNTNHQFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ7</accession>
    <name>A0A654DXZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein HesB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024797419" evidence="1">
        <location>
            <begin position="26"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="667" mass="75426" checksum="DAE3EF7E58B76867" modified="2020-04-22" version="1">MMNRNLILVIAISTSLLFSAKTSEAQSGSKSISVKELRNKIAGAWVGQMIGNIYGLPHENKYVSAPGDEGKWPYGYTKNLDKLRKYEGAFSDDDTDVEYMYLLNMEKYGYEPTYEQMREAWMYHIRDRVWLANRAALGLMHFGYTPPFTGDKNINPHWFQIDPQLINEIWAYTAPGMVQYAAQKSDWAARITSDDWGAEPTVHYGAMYAAAFFEKDIRKLIDIGLKELPADGRYAQTIRDMIALHKKYPNKWQDAWKEMAEKYYVNEPDLTKTIWNANLNGACGILAMLYGEGDFQRTLDLSCAMGFDADNQAATVAGLLGIVYGFDALPENLYLPIEGWVKPFNDTYINITRHELPDASIEDQIDRMLAMTLNLVKGKGGKVTGEAGQEKVIINTKATFDVPLEFYIGPAAVLEVNKAVDFTFYSEANKNYNWTLVQGDLPKGTSFEKGRLTGVPEIPGKYKITIQLDNGKKYLKKDFELLVRNENLANSAKSVLANVNTLNRDVLDSCWTTFGNSMYSDTPEIIRDGKLNGAGSVFYSLAAKAKIPKVDYYGYEWEEDQEIDMLVFNTGGMEEFGGWFTSLNVQYKNEEGKWVSAERTSIQPGLPDTDIVFFQPHFAEYVITFKPVKTKSVRIIGDAMIQDHWNKYTKNVSGFTSIAELGVYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY02</accession>
    <name>A0A654DY02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024904741" evidence="1">
        <location>
            <begin position="29"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="2534"/>
            <end position="2601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2610" mass="287517" checksum="C80FEF0C92C1EF7B" modified="2020-04-22" version="1">MKKTLTKLFRQNLKALMLVMMTSFFAFSATGQYIQDAPDPGVTHYVGQDTTVNVDASGYNGGDTTLWLVYDWDGTLEENYVLGSVVTGSTKSDIDIDFAWPETGNVELTVVITVGSTFEDDLETLYASNYTYTGGAVDGGLSFYRAGARSYTSTAVDLDTDEPVYMSVYLDVSGVSEDNYVRVRYSTNGGAAYSTLLDDNDSSNFYGGSGWVDFTLPEAAKAAATIIKISQVGSDTLGTNEQSWEMYFDDGNVAEFNIGDAYNDIDGETGSIYFISPYSLEIDDLLDEDDVSVLNGDVYPGDELVLSATLYGGTVSDYNYALVIEGVVISETPSDTDDGLGLVEFTFDAPVDMEYDENLWFEIIPYALADASYNAGFEFDADFVSELDEEDPDNEETLIVGGEDDGSDASFYEAGERSATTQALNLSGLLDPEMSFELARLNDEPSPAGTDIIFEYSTDDGATYTELAAFVLNDLPYEDDDTESFYFYGTDDEEADFDFPSAVLVDGVIFRFRQESNIGADEDTWYLSNFDIDAGDNRADDVEYDEAYFSLYAPEISLSPLNISETVPYPMTELTLDWTIDAGEFPANTGAKLYLDGDAAGGYDILVGEVADVTLGTMDFTVPPLEAGDYEMYLMVNGVDYGTVYLPIYDLGISITGISYDPSVSIGGEEYAVIGSAITVEYDISGEPGEDAELTIAVWDYDEEEYVTIGMSSDFTGSITATLPTDINLDDDGESNPYVQIGVTAGIFSLGFDETVYDVYTQGSYLSNIYDNDGNNVFDSWSGTLNWYNADDFVGSGERYAVSSILDTYRGGESGLQGGEITVTLRSLPSYNGSFTVSLEVSTDGEEWEWVDDVTFSGGNQNMDLEYLIEEEYFSETFQYRVIYDYCCYGSYSYGSKIYNVEFVRPEYMEVIGDESEFNFRRPLLTVADLEDKYIQIGEEVTINYNAQFFPEDVEFALKFQAQGNYIVLATSDTHGAGSFTVNIPYDLEETLDPPHVEWDNYSFKVDAFIPETPGGAYSDGSYIELEDEEDFIAVEGTSDTDPYFEFDESGERYVTTRAIDLTVASNPTLEFYWNNSFSTSSTKSLVPRLEASTDGGATFVAVRVNEVAEDEEEMLDSSLLYYSGSYYIEIPEALITDATHFRWRQPLNLGADENVWEFGDIEVTFDDENKYTGYDKDNKIEDIEIYFPDLDGYSFDQADPDVAIFNGSTFEFAFGPYLDKTEEEIEEEELTWDEFPEGTQFNFYIDVFDPTTDDDLMIASFTAGTTSGEVEIPYYVTNGNYDVYVDVYYEVGNEAETILWFEENTWIGDFDVFNRAIQLQSDADQGTILYAGSTVTFSIEVENETSALDATDLYANLIWDGWLLTSQQGFDDITMDLPSFISGNQEFEILVSEGGPLGENLTELEENELGSLNEDVSNFINVAYAIVDDGEFYSDYEDEYDVIELIDAPNRKLTTRDFEAGELENTSLLIIDTYFDVDGDDLFESQYMIFEYSIDGGATYTSLDTLKDYVEDDLKYTVTDEMKSNDVRFRWRQTENEGMFIIYDISFTYAESLPFDYTGVYLNVKKQAVIITSIDQEASGSCFASDITINYEIRGRFGADNLLKVYYDNGDDDDDLEGYEFPATEGSGSVTVQVAAGLIDDDQFDGDAEDNTDFKFKLYADDDTYEDIDEDFEVWSVYSDVVEVVAPIEKGTSAGMYSGGDVSECDPEAFVYLYDPQMYFLYEVLNADTVFASLEYDDESSSTIELGDLTEAVDLTLRVTSRSSAGIVCNVHTFNSSIEIEITPNDVLLRDRYTTSGTIEVTEGESKTICSGDDETVVLSLANYDADDSEVEWFRDNFDNPVEADGDDFDNFEVSGAYFARITEGECSYVTVAMNVTVLEKAETPEITVVSNDISCGDGTAVLSAPEGFAHYLWSNGEITQSITVDEADSYSVRVSNYPIVSTSDAYGCASSSSESVVIENNNFEQVYLSTFYYNEYSSSSYADNYIEDGETLTNCGDDVIYVFVEDDNNYYGGQISGILTLYKDGAVYDVKNGDVAGTNGYTNNNFEITESGEYYVEWSGVEVENACTSVSETFTMTINEAVEERPVITASGDISFCEGGSVTLSAPAGYPFYRWYNSGTVVGNGETLEVADDGSYRVRVSNVAFGNGCGSDYSEYTYVTVYEEQDLMIGYANTTSSSYQYEEGDVVEVCSSDNFTLWVNNEVTSGATYTWYRDGVAIPNANSTSRKVTASGTFYAEVTYGVDDIDLAAPCVYTTPSVVVNFNQKPAAVRIAEPTNVDFCAGEINLTLTADAGAAFYNWYHNGSQMFDEPSTSNTLLINDGGTYSVTVETGDIGCESARSNIITIDERAKANPNIYVYTDGSDCATGDVTVYLTNTSSSTVYQLINRETGAEIGSPVVGSSGTSVYTTLSGLTEPVALLVEASYTDGSGCSDISSSVRGTATPNAVILELDGTEITAEVSSTGGYEVSWYRNGTLMRNATGNTINVVDAATYSVEVTFDDGCTITSSTVDVGAGAPAAGRSASNGRIVANTFPNPSADFVNVEVPGEHFGVYQVQIMTLSGQVVISGEFTKDQESYVERIDISDLENGIYNMMVVKGKQVENIRIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY16</accession>
    <name>A0A654DY16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unsaturated chondroitin disaccharide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="401" mass="46151" checksum="D92E166FCC8AB868" modified="2020-04-22" version="1">MIRKTLGIVCVVLISYGCHLKQKEVFDVDESLQYCVEQADQTISQIPDDEKSLPRNIAPESKEWNYVTYQDWTSGFWPGTLWYLYEYSQEPNLKEVADQFTQYLRPLSEKPATDHDLGFQVFNSFGNGYRLTGNAEYKKVILRTADTLATLYNPAVGTILSWPRPVPNMEWPNHNTIMDNMINLELLFWASKNGGDSSLYQIAVAHAETTMANHFRPDFTSYHVVVYDRETGERIKGVTHQGYSDESMWARGQAWAIYGYTMVYRETKDPKFLDFAQKVTRPYLDNLPEDFIPYWDFQAPNIPDEPRDASAAAVVASALLELAEYSDKALAKEYRDKAIAMLEELSSPRYCPEDGNPAFLRHSTGHYPNGSEIDYSIIYADYYYIEGLTRLKRIREGKKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY54</accession>
    <name>A0A654DY54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17702" checksum="B623D0642CF7CFF5" modified="2020-04-22" version="1">MNVILQFYEAFRKLDAEAMAECYHPDVTFEDPAFGVLKGEHACNMWRMLCKTQTGKDFLVVFSGIEEDEEKGKAHWEAHYTFSQTGRRVHNIIEASFLLKDGKIIQHTDHFPLYRWARQAMGFSGFLIGWSGFFKKKLNAKTAGLLAKFEASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY80</accession>
    <name>A0A654DY80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cbb3-type cytochrome oxidase assembly protein CcoS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccoS</name>
        <name evidence="2" type="ORF">MARINOS108_11895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004714">
        <property type="entry name" value="Cyt_oxidase_maturation_cbb3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03597">
        <property type="entry name" value="FixS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00847">
        <property type="entry name" value="ccoS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="7617" checksum="4EFFDBEACCBB30FF" modified="2020-04-22" version="1">MSVIIVLIGFSITVALGFLFAFIWASGSGQYDDDYTPSIRILFDDEPNQTFYVNNDSHQPARRKGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA2</accession>
    <name>A0A654DYA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="81" mass="8914" checksum="6B5654D44922D73F" modified="2020-04-22" version="1">MNTTDWLGSVGVFLILLAYLLNTLGKLTTKDLAFILLNLTGAALACLASILLDYLPFIILEGAWTVVSCFSLVRYLRNPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA7</accession>
    <name>A0A654DYA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="493" mass="53564" checksum="0D133D1A6BF9EAB5" modified="2020-04-22" version="1">MLSKKSIGALTGMAVFGIILFLPTPDGMNPEAKGAAAVVALMSVWWITEAIPVYVTAFIPLVLYPSMHILSPAETAANYGHNYALMFLAVFFLAKAIETQNLHKRIALTIIHVFGTSRQKIVLSMMIATALVSMWIANVTTALMMLPIGLSIIGKDEDVEKSNRFAPALMLAIAYSASIGGLATLIGSPTNMIFVGIFDKMFPEAPPVNFFVWLKIGVPILVILIPVFWYFIINYFKIDGDLSKNLTIIKDELDALGKMRSGEKRVLYIAAVTVFAWVFKNDLIFGSLVIPGWTGLFGISGQIHDSTIAMASAIILFLIPAGDDKRLITWKEASQVPWGVVMIVGGGYAVAEGFVSTGLADWLGGQLSFISGFSFFYILITVMAFVLVFTEFNSNTASANILLPVLASTAIAASVNPLLIMIPATVACSCAFMMPAATGPNTVVLASERVSVSQMVKIGFWLNLITLFLLTMILYFIIVPWLDLEMTLPIWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF8</accession>
    <name>A0A654DYF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_12079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011403">
        <property type="entry name" value="PPi-PFK_TM0289"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036482">
        <property type="entry name" value="PPi_PFK_TM0289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="10">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="44880" checksum="D0F0875915C8E107" modified="2020-04-22" version="1">MEKSVAIICGGGPAPGINTVISTVAKVFLNDGYRVLGVQEGYKGLFAESPQIKEFDFEHADRIFSRGGSTLIMSRHKPKDDEFTVDFFVKNNVKLLVTIGGDDTASTANRISKFLAKNNLDVKNIHVPKTIDNDLPLPDRNPTFGFHSAKDEGVKIGNTVYEDARTSHNWFVMSTMGRSAGHLAFGIATGCHFPMMIIPEMFNKTKPTLDKIINLIISSMVKRRILDIQYGVALVSEGVFHIIDVEELKNCGILFTYDDHGHPELGNVSKSNIFNVLVQEKLKKLGISIKSRPVEIGYELRCCRPIGYDLTLCTLLGIGVKKLYDEGISGCIVTANSKGDISPMYLSEFEDANGKIPPRLVDMDSQIAKLCLQNMHFITAKDYAAAGALLDHPEEYDFNKILNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG9</accession>
    <name>A0A654DYG9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-amylase</fullName>
            <ecNumber evidence="2">3.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">1,4-alpha-D-glucan glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012850">
        <property type="entry name" value="A-amylase_bs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031965">
        <property type="entry name" value="CBM26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07821">
        <property type="entry name" value="Alpha-amyl_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16738">
        <property type="entry name" value="CBM26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00810">
        <property type="entry name" value="Alpha-amyl_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024810315" description="Alpha-amylase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="27"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amyl_C2" evidence="6">
        <location>
            <begin position="347"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="773" mass="83313" checksum="EAE3DADB43234447" modified="2020-04-22" version="1">MMKHLLLSIAFLLLMMSAGAQAANDGRVLLQGFYWESSHDYPGDWYSHLEGKSADMNAAGIDMIWLPPPSDAGSLEGYLPRELNNFANSYGSLAEHQSLLSTLNGLGIEAIADIVVNHRVGSTNWVDFTNPTWGTNSITGDDEVWSNSAYSGISLRGNNDSGTPYAAARDIDHSQGFVQNDIKAFLDNLKAIGYDGWRYDFVHGFDPYYFTVYNGHTNPTFSVGENWSANKQVVQDWVNATGSTAFDFSTYYTLKAVIKDNNYSYLSTQGAPSGGIGWDPRHYTTFIENHDTPDYDPGNNVLNGNNVGQSYAYLLTHPGVPCIYWPHMYEWGSAVTNEIKALIQVRKDAGIHSESPVTIHRSENGLYVASIAGDIHSVFLKMGYGNWGDPAAEGMGSTWTLAASGTNYAVWSEGGTGGGGGGGSMTVYVQGYSHAYAWDSNQNPLLGAWPGTAMTAGAGGWNEVTISADCSNVIFSNNGAGQTADLSTCNDMPYYENGTWYASEPGGGGGGSSGSMTVYAQGYTHAYAWDANLNPLLGAWPGSALGTGPNGWSEISISEDCANIIFSNNGSNQTSDLYTCSDSPYYSNGAWYATDPNGGGSTLTVYVQGYSHFYAWGDGQTYTNGWPGSTLTNNGDGWYYGVIPANCSNVIFNNNGANQTADLYTCGPTSYYANGSWSGSGSRAAIFDDNDLTIYPNPFFSQASVSFSLKTAAHVRLEVFNTSGQSMKLFDSDLAEGGHQITFHASQLPPSNAMYIVRVSVNDEQYTRKIVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ0</accession>
    <name>A0A654DYJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="205"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="46306" checksum="2DC226FB2681766D" modified="2020-04-22" version="1">MNNKIKIIEVSEPKHVERFLQLPEKVYQGDKNWIRPLDKDIEQVFDPNKNSFHSHGIITRWIAMCGDTCVGRVAAFVNFRTANSFKQPTGGMGFFECIHSQDIAFSLFDTCRDWLKEFGIGAMDGPINFGENNAWWGLVVEGYEPPLYRNNYNPSYYRDFFERYGFQTYFEQYYYNYDFKKGLSPRYYEFGRRLAQREEYHCENVDLNNIEKYADDFREVYNQGWKTHDNFKEMKAKRALSLFKTMKPVIDKDLIWFLYHNDRPIGFIIMIPELNTLLRNFRRGRFGIIQKLQLKIGLTMKMCKVAYGSVIGFIPEFQHKGLEALLFYHIHQKLVPEGKYETLKIGWAGDFNPRVVNLYQKLGFKKVQTSRTYRYLFDPSMPFERAPIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ08</accession>
    <name>A0A654DZ08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase A-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="54"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="627" mass="71299" checksum="ACF42F2D73CA76DC" modified="2020-04-22" version="1">MFIKLLSSLLMTDSKMAVNKTFLYVLHSAMRMSILILVLNLHSCSPQTTSAKKPNVILILIDDQGYGDISALGNPFIQTPNIDQLHDSSVRFTDYHVSPTCSPTRAALITGHHSNRTGVWHTVNGRSLLLERETTAAEIFKDNDYSTGIFGKWHLGDNYPFRPQDNGFDEVLTHGGGGMEQTMDYWDNDYFNDTYLHNGVLQQYEGYSADIWFEEAIEWIDSREDQPFFCYIPSNTAHSPYFVEDKYYKDLEGNDSIPHAPFLGMIRNIDENVGKLMAYLKESGKLDNTIIVYTTDNGTAHGAKAEGHRLDGFIGQGFNAGMRGIKASKYEGGHRVPLFIRWDRGEINQGKDIDELTAHYDVLPTLVDLCNLKVNPKIQFDGQSLVPLINGDHSAFADRIVITNSQRIEVPQPWRRTSLMQGKWRLVDGEELYNIETDPGQQTNIADQYPDKVQAYRDYYDSWWAKISPTYEDQPFIYVGHSADNPTRLIAHDWHTEAEASPWHQRHIRTAVKDNGYWLVDVQESGSYSVKLRRWPEETHLSLHEIAEVRPSLPGTSVTESVESTSISVSKARLNIQDIDEVKEVDPTAEYVEFVIDLKVGESKLQTWFTLDNGETLGAYYVSLEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ09</accession>
    <name>A0A654DZ09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021993">
        <property type="entry name" value="ATPase-cat-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12156">
        <property type="entry name" value="ATPase-cat_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="5">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="821" mass="90990" checksum="A846AEE119AF381C" modified="2020-04-22" version="1">MINVSYKPEYCQTLTCLSKLVLWVPEVYMTSSARISPKLRCHHCGTSCEEDHIEYEDKDFCCHGCRAVYELIEHNNLGAYYQNRELHAGRVAEEKEIHKKYSFLDQKEVSEGLLHYSDANQSAVRFSLPGIHCSSCIYLLEHLPKLESRIFSAEVNFLRKEITILFSKAITLREVAIILATLGYPPAIHLDSVEAPKPRKSNKQVLRIAVAGFCFGNSMLMSLPEYLDSAFQAEESFRHLFGWINLFLSIPVVFYAAQEYYKSAWRSIRHGYMNIDVPITLGIFTLFVRSGYEILWAAGPGYVDSLAGLVFFLLLGKWYQSKSYEALSFERDYKSYFPVSVTRVVSGQEEQVLVRDLKPNDCIVLHNQELIPADGILQSGKAKIDYSFVTGEADPIPVSEGERVYAGGRQLGGQIEISLEKAVSTSKLTQLWNNQTFAKTANPYDNLIDKVSKYFTVVILILALGTGIYWSVADPSKIWDAVASVLIVACPCALALALPFGLGHGMRILGHQGVYLKNAGIIEQMAKTETIVFDKTGTLTKNNPSKVSYQGAELNPIQLSLLKTACANSAHPISRLILGTIAESVEKMAITDFNEQVGKGLRAEIAGHVVKVGSSAWINRSSNTVQETTAYVDIDGVFIGFYSIRAEYRADIFSELKHLRNDYRLCLLSGDNASEAPTLAPYFDQWAFNQKPEEKLSFLQGLQGHTLMIGDGLNDAGALKSASVGFAVCEDIHQFSPACDALVEADSLSRTGSILRFSKVVMRVIVAALVISFVYNIIGLSFAVSGHLTPVVSAILMPISSVTVVAFITLVINGISKKYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ55</accession>
    <name>A0A654DZ55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_110055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024949985" description="TonB_C domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="13122" checksum="D2C4AD27CE9C5728" modified="2020-04-22" version="1">MKKYIFSLALLTVAVLAFATSDSNLSLQAKAINLDEVAESIKYPTMSNESGIEGTVIMYLEIDAEGNISNTTALAYPCSKLKETVELALNDLKFEPARNIEGEAVASTLRIPFDFQLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ58</accession>
    <name>A0A654DZ58_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ORF">MARINOS108_110119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD15968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="17102" checksum="074F1D661998F6E5" modified="2020-04-22" version="1">MAFFTSEYECKLDTKGRLVLPAKIKSSLPEVSTHELIIRKGFEQNLILYPMLEYKKIHAKIAALSEFNAEQRKLKRNFFRSIQQVDLDSAGRLLIPKQMLAHAGLDKELILIGMGNYIEMWNPQHFEEHQIDDSEEYSALAQKYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ88</accession>
    <name>A0A654DZ88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectin degradation protein KdgF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdgF</name>
        <name evidence="2" type="ORF">MARINOS108_11986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025499">
        <property type="entry name" value="KdgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029883">
        <property type="entry name" value="KdgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13714" checksum="869E2875BA2E7289" modified="2020-04-22" version="1">MGRKSEKYILTKEMEWEELGGGVSRKMLGWDNQIMMVQVKFEKGAEGSPHQHFHTQTTYCVSGKFEFVIDGVKQIVSGGDGVYIEPNLLHSAVCLEAGMLIDTFSPVREDFLDGSGVSYFGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB7</accession>
    <name>A0A654DZB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUMOD4 motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="21166" checksum="7446A0F4ECEDD191" modified="2020-04-22" version="1">MEEWKVWESDEIRNKFLVSSYGEVKSLYFDPPKLLKHYKNMGYRAIPTRKKDGKNTLIYVHKVVAELFVPNPENHTHLIFIDENKGNPEADNLRWVDKATFKDHMSKYHKSAYTYDKDFTPNNKLTRTQVAVIKKMMNDPNRKTRVKIIAKQFGVSVGTIFSIKRGDSWKHVKAAGSDKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC4</accession>
    <name>A0A654DZC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="23086" checksum="D97107AF25AF2D02" modified="2020-04-22" version="1">MDKFVVSVADASHIHYAEQICDMIADSAEKRGTGIARRSTEYVQGKLADGKSVIALTKSGKLAGFCYIETWGHGKYVANSGLIVNPDYRNNGLAQAIKARAFKLSREKYPDAKLFGLTTSMAVMKINSDLGYRPVAFSELTDDEAFWKGCSSCVNYDILTRKNHQHCLCTGMLYDPEEKKRKWKQRSKKVQEKLMMWKQKVQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK6</accession>
    <name>A0A654DZK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydratase IlvD1</fullName>
            <ecNumber evidence="3">4.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ilvD</name>
        <name evidence="3" type="ORF">MARINOS108_11774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="574" mass="62621" checksum="ADC99D4EA2219C98" modified="2020-04-22" version="1">MSDKKEKLRSEEWFGKDDKMGFVHRSWLRNQGHPDHMFRGKPVIGICNTWSDLTPCNAHLREFAEIVKRGIYEAGGFPLEFPVMSLGETIMKPTTMLWRNLVSMDVEETIRANPLDGIVLLTGCDKTTPSTLMGAASVDLPTIVVPGGPMLNGKWRGKDVGSGTLTWQLSEGLKEGTITEKDMVEAESCMSRSAGHCMTMGTASTMGVMVEALGLTLPGASAIPAVDSRKKVMAHLAGNRIVEMVREDLKLSKILTREAFENAIKVNSAVGGSTNMPIHLTAIAGRIGVDLDIEDFDRLGSQMPMLVNLMPSGKYLMEDFFYAGGLPVVIDEIRERIHIGAITANGKTIGDNCRNAPCYDREVIGTVDAPIKENAGIVVLKGNLCENGAMIKPSAATPALMQHKGKAVVFETIEDYHQRIDDPALEIDETSVMILKGVGPVGYPGMPEVGNMDLPEKLLRKGVKDMVRISDGRMSGTAYGTVVLHVSPEAAIGGNLALVRNGDLIELDVKGKRLTLHVSDEELAERRKHWVKPKPVAERGYTKMFIQHVEQADKGCDFDFLKGSSGSEVTRDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM4</accession>
    <name>A0A654DZM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="82"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="352" mass="38803" checksum="F10A826BC2EF9362" modified="2020-04-22" version="1">MIIPKEPKLTKEQFEEVVSIVEEYGCRVQPIEGHHRTIYAVLGDERETIMVTRILGLDYIDRFDAVDTPFKLMDIKSELAHHKIKIGNIILGEAPFIIAGHCTIDPKNPNLFIESAHAMKEAGAAAIRGGVWKPRTMPYAFQGDDASMKILIEAKEQTGLPVDTEVMDEHQLSIAVEAGVDILQIGARNALNYSLLKKVGQETADKQIAVLLKRSMGMGPVNEFIAASEYIAAGGNPDVMLCPRGTSPTMDGYRNYPDECITPLLKEKTWAPVIVDPSHSVGRAKYVPSAAMAAMAYGADGVIVESHCDPKKGIGDDPKQAITPDVLKKLIQDIHQIWEIRKHYKKELPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY3</accession>
    <name>A0A654DZY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7068" checksum="78C3E438A085AB7A" modified="2020-04-22" version="1">MITTLRRIVYFGGLFIALMAIVLIMIKNDIGYIPEYLSVFMLSLIFIMGVLLIFLIAKRGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E015</accession>
    <name>A0A654E015_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="22858" checksum="BC724406B0E2DF76" modified="2020-04-22" version="1">MINEFQTIVHPTEGFYKEKGSKFLSFAYHVKTEDDIKAHLEALRKQYYDARHHCYAYIIGLKEQAYRANDDGEPNHSAGDPILGQIRSKELTNCLVVVVRYFGGTKLGVGGLISAYKIAAEDALNKVEVVKIYSQTRFSISFGYEQTSEVERALAEFVVDYEDKVYTADCQFVGLLRDEDVPVLAEKVSLLKGVDFQVLQGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E023</accession>
    <name>A0A654E023_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheY-P-specific phosphatase CheC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22462" checksum="60C301DA031BCB7D" modified="2020-04-22" version="1">MLDKLNENELEIASKLVFDGLSMAKKSMEQILQSPISIEKIDYSSSADVPLPKFEDLGGQSVHVIKTKLIGELKGTSHLIFREDEVAKVFKACLPAKLIDSDTPESRMMKIGFLTEIDNMMAAAVITEFSNFLGLEIYGHVPSLNVVKSTEVNSYLEKEAGEFDAIIRFKAIFHGVELDISPDFVWIFQEEFVDKIRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H1</accession>
    <name>A0A654E0H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="361" mass="41145" checksum="3D93BC986220C145" modified="2020-04-22" version="1">MKYFTHLIVCLVLVSACETLYLLDEDKDVARQIVISGYINQGPGPYHVKIQQTSFTGEAPTDVFNAQVTLVDEGGNREDFVAQTFIQDNKSKVNYRCPANIVKGYPGRSYHIEVVLADGRRYETEPDRMPFYQGQDEISWEETELITTSTLGLDVSVPAVKCHLTTRFQQQDEPIFLTWLGEETYAFFQTDFPDPFNNTPPPCYIIRPIGAEDLNLFTNVGYTKSEFEVPAIITRAIDKSFQIKHIFTLYQYSMSERNFQYMRSIEALTENSGSLFDTPPGVAYGNVIPDQEDENVQGFFQAVLMDTTRIAVFPNFLNTQVSDDCAYLSGTFEYDYPNICKNCTLLPNASLERPDYWVDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J2</accession>
    <name>A0A654E0J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024875964" evidence="1">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="19945" checksum="61E36C70736FE848" modified="2020-04-22" version="1">MKIKFYLGFFLLLGITLSHAQYRQSGRSGGLSDKIYFGGGGGFSGGTQYLNLSVSPLIGYKFTEQFSAGLQITYQYTKFGQATASNYGGGPFLRYNFSPKFFGYTQYEYLNFGLLIPGAPEPERYHFNSWFVGIGYSEPLGRNMAFNITALYNLLYQDGSNSPYNSPLQFRVGIVAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N0</accession>
    <name>A0A654E0N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="29750" checksum="85AC8DC12B83565B" modified="2020-04-22" version="1">MHLYGLDGNGMKNYLHIMIKYFGGLFLIVVGCTSPKPDGSDGIAAVPVALQKVLETHGGLDRWKSFQSMEYDMEGEHHQINLSDRKTRVDKEGGGIVAFDGENVWVTDSADLQGARFYYNLFFYFGAMPFVLADPGISYDTVARRQLLGNTYEAIRISYADGVGQSSRDSYILFYDQDSHQMEWLMYESTFHSGKARNEYNLIHYRDWVLVNGLQMPSKIQWHYFDGDSVGGVTGDATFEQIELRESALSDSLFVMPADGLVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E138</accession>
    <name>A0A654E138_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="276"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="39720" checksum="F1E896C19421A3DA" modified="2020-04-22" version="1">MAFGLFKKKKKEVAADTRFQTLKIKEVIEVAKEAVNVVFEKPEAGFQYKPGQFITIIKEVGGKKIRRAYSLCTTPFEDEYPAVTVKRVPGGLMSNHINDHFKAGDPVEIMEPMGMFTTEYSASTSRKVVFLGGGSGITPLYSLMRSVLIKEPSSSVALIYGNRSEEYVVFKDQLNALKAQYGHRFELVHILEEDANGFAQYTGRPTASMIGEITKGLGTNDNTEFFICGPAPMMEIANEGLLEIGIREEKIRKESFEAGKTSPADIIAPEAPAGSSEVTILLDGEEHVVNVNKGEAILDAALDQNIDMPYSCQSGLCTACRAMCLEGKIDQENAEGLSESETAEGYVLLCIGKPMSDTVKVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E167</accession>
    <name>A0A654E167_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SNARE associated Golgi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="22891" checksum="2761FDDDCBFBED78" modified="2020-04-22" version="1">MQPDEQREAMERTRFFLKNLFRGILWLAAIVGGYFYLKANYNFSLEGVLGPLYDKPFVIFGIFFTSETVFGIIPPELFMIWSLRNEVLQQYILNVAGLSVLSYLAGIIGYYIGSHFSTTQLYRTLQKNYLAKFEKHVNKFGGFLVIVAALTPLPFAGICMLMGAVKYRYRRFLLMSMTRFLRFTVYAIIIWEANIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E7</accession>
    <name>A0A654E1E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SusC/RagA family TonB-linked outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="105"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1004" mass="107380" checksum="5D45704997FCF775" modified="2020-04-22" version="1">MLMGIVVLGQQTVSGTVSDAQSGEPIPGATILIKGTDTGTTTDLDGKFRIQIENETDVLVFSSIGFSAVEEVVGSRAIITVSMDADITQLGEVVVTALGIERDSKTLGYSVSRVKGEQFTKAREISVADNLVGRVAGLNSSAPSTGPGGSSRVTIRGNSSLSFNNQPLYVINGIQMNNDNLGSVGKWDGADFGDGISSINPDDIEDITVLKGGAAAALYGQRGRNGVILITTKSGKSSQGLGVEFNSNVAISKINDFRDFQEKYGQGTLGAAPTDQTSALNTGLTSWGAPLDGSMVTLFDGKQHPYSAVSGDNLTDFYETGATYTNSLAISGGGESGSVRLSLGDLRNSSVYPGADYKRQTINLDASYKLSPQLTGSANVNYTKDGASRTKVNDAPGNGNYAIMFLPPNVDAEYLAPGYDELKNEIRFGSDAFTTNPYFAANRFITETSKDRVLSVASLRYAPLEWLYVQARIANDFYAFNATQITPTGTAYRPTGGLDLQRTVNYNETNADFLVGINKDVSRDFSIGVTLGGNLLKMQQKTVEVNASGFAFPFLYNPGTATTKNANVTEPQKEVHSLYGSVELGFRDMLFLNITDRNDWSSTLPSGNNSYNYPSVNLSYVFSESLNVPWMNMGKIRAGYARVGGDAPVFATSLYYGTLGNAINGVPLGNVDNNVPNPQIEPLQVTELEVGGEMEFLQKRLFVDLAWYKKQTLNDIVNVGISRGSGYQTAVVNIAEIENTGVEFLLGGVPVKTPALTWTTTFNISNNKNTVIGLAEGQDKLTVGESRNGRAFIEHVVGKPFAQVMAYDYMRDDAGNLILGATGLPQAASELTSQGTGVHPVTGGWSNDVKFKNLTLSFLIDFKYGGVIYSGTNAIAYGNGLHKATLEGRGDGITVSGVDAEGNAMTSTVTDQNYYGALAGISKLQVYDADFIKFRSLSLTYNFPNLGNIKGLSISLVGRNLFYIKKSTPNIDPESNYTNGNAQGIEYLGLPTSRTYGINLGIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F7</accession>
    <name>A0A654E1F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ORF">MARINOS108_120494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="92" mass="10523" checksum="31DD1C011E455268" modified="2020-04-22" version="1">MARSLKKGPYIDFRLEKKVDAMNESGKKSVIKTWSRRSMISPDFVGQTFAVHNGNKFIPVFVTENMVGHKLGEFAPTRNFRGHIAKKDKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y8</accession>
    <name>A0A654E1Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="8049" checksum="E41E66E97CD649CB" modified="2020-04-22" version="1">MKHLIWYSSKTENYNHGSSIDLKISESLMGEKMEVLYEMEESEERLVRKIVSQLNNARLEKARNYQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y9</accession>
    <name>A0A654E1Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="244" mass="27704" checksum="ACB971ECAA64F69B" modified="2020-04-22" version="1">MTEKENEVSKEQEEKILEAFKDRDWNEIKSSDSWAIFKIMSEFVDGFEKLAKIGPCVSVFGSARTKDDDKYYKMAEEIAAKLVRHGYGVITGGGPGIMEAGNKGAHKQGGKSVGLNIDLPFEQFNNIYIDRDKLINFDYFFVRKVMFVKYSQGFIVMPGGFGTLDELFEALTLIQTKKIGRFPIVLVGKEYWGGLFDWIKNVLLAQANNINEVDLELFSIVDTATEAVHVIDEFYNKYLLSPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E225</accession>
    <name>A0A654E225_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YfiO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025048502" description="YfiO domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="2">
        <location>
            <begin position="495"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="606" mass="70379" checksum="6EB2E14F55E6E227" modified="2020-04-22" version="1">MKKHTLKTFLLIILFIPQLSVHAQSSDAKLANEYFQQGEFDKAKLMYEGLEKTKQAIPLIHANYMQLMLDANELKEAERYLQRVLKFFPSNLQYQVDLAFYYQYAGEFDKKEKFLNELIKSYADNQYQLSTIAQNLASRQLYREAIFFYEKARAANGRPSSFALDMAAIHRLTNNKPEMTSEYINYAEGNPANLTYVKNLFQNILTEEEDQDFLEQTLIQKTQRNPNETLYSDLLIWLLLQRKDFYSAFIQGRALDKRNQQPGNECMRIAQIAYDNKSWQDAIDIYQYVINTYPNSYNYPPARRLLIRSKENKVKNEFPVDRLAIRNLADEYAKLYEEMGPNPTTLEALRNKALLHAFYLNELPQAITLLNAIIHNNRSPASLISESKLDLGDIYLLTDQPWESTLLYSQVEKAHKESPLAYEAKLRNARLNYFTGNFSLAKSHLDILKLATTRTIANDAIALSLLISDNTVFDTTDQVMKDFASVELMIFMNKSEQAKAKLNEILEQHPGHSITDEIYWLQARLELEAGDYMAAILHLDKIITQYSYDILSDDAFFRKATILHDHLHKDQEAMSIYQEFLKKYPGSRHAAEARTRIRKLRGDLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E273</accession>
    <name>A0A654E273_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="94" mass="10415" checksum="C0AB22A53EAB20A7" modified="2020-04-22" version="1">MKNNRPLKIVIVVALLLLIPLIAMQLTDEVTWSVFDFLVAAIILLSAGFILDLILRKVKSTLYRIAFSIALLILLLLVWAELAVGIFGTFIGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E274</accession>
    <name>A0A654E274_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">MARINOS108_10142</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="6"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD10631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="44351" checksum="97A708EFA57524AE" modified="2020-04-22" version="1">MELKRVVVTGIGAVTPLGNNKNDYWDALAKGVSGAAPITRFDSEKFRTKFACEVKGFDPLDFLDRKEARKMDPNSHYGMVAGDEAIVDSGLDLEKTNKDRIGVIWGSGIGGFTTFQDEVVSYAKGDGTPRFNPFFVPKMILDITPGLLSIKYGFRGPNFATVSACASSNNALSDAYNYIRLGKANVILTGGSEAAVIETGIGGFNALKALSERNDDPTTASRPYDKDRDGFVLGEGAGALMLEDLDHAKARGAKIYAEVLGVGMSADAYHITAPHPDGDGIVLVMNEALADANIKPTEVDYINTHGTSTPLGDAGEVKAIQKVFGEHAYNMNISSTKSMTGHLLGAAGAIESIASIMALELGIIPPTINHFTDDPEIDPKLNLTFNTAQKRDVNVVVSNTFGFGGHNASVIFGKYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E292</accession>
    <name>A0A654E292_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024929191" evidence="1">
        <location>
            <begin position="25"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="310" mass="33870" checksum="362B7792F6700A4A" modified="2020-04-22" version="1">MIMRKFISYAFVVAMILSCGSVGAQDYAFRVLANKGTNQVKKAGAGQAEVLKTGAKLSSGDEIIASDDAYIGLMHKSGKTTEIRGAGTKKVSELEKNINTGSSSIASRYASFVMNKMNEEENTNNRSRLNATGAVSRATGSAAINVMAPSQADLLGDLAILRWDAPEGFTEDDSYVVKIENIFNEEIYSEETKKTSVALDFSDEDLAYDMGLYLVKIYKKGDDEIASGEVGIKKVKSGDKVEVQENLANLKSEVSDDSPLNKIIYASFYEENGLILDALTKYEEAIKMSPDIDDFQELYQNFLIKNGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G5</accession>
    <name>A0A654E2G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21930" checksum="3DD97ED4B128F7CC" modified="2020-04-22" version="1">MRNYFDMRNFLLPVLVFILALGCGENRQSTVTLKVYFDLDSLLDRQVALLSEKKVLLSKEVAMDDQKETLELQPGSAEWESEFVIIRDFNLNKSYYVGAYGTAANADYIQYKLEDDIDAPVKVFEVFKANGQVERIVSNYYEDKSIYQHRRNLELTFENGQLSAYQIRGFQKMILKDTIQYTISGKITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L5</accession>
    <name>A0A654E2L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025064419" evidence="3">
        <location>
            <begin position="23"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="T-box" evidence="4">
        <location>
            <begin position="93"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="761" mass="86407" checksum="D1C709D39EA15562" modified="2020-04-22" version="1">MRMKIWIIRAFFLCSLVLEGNAQINDPVSYVSTMVGTQSKHSLSTGNTYPIIARPWGMNFWTPQTGKMGDGWQYVYTEDKIRGFKQTHQPSPWINDYGQFAIMPVTNKLVFNQDDRASWFSHKAETAHPYYYKVYLAEHDVVTEIAPTSRASVFRFTFPETDQSYVVVDAFDNGSSIKIHPERNMITGYNTKNTGGVPANFKNYFVMVFDKPFEYQAAVESNKIREGTTQWTGDHAGAVIGFKTTRGEVVHARVASSFVSPEQALLNLKEVEDKSFDQVKQEGKAEWNDILGRIEITDTNIDNIRTFYSCLYRSVLFPRTLSEINAKGEVIHYSPFNGKVVAGEMFTDTGFWDTFRALFPFLNLVYPSMNAKMQEGLVNTYHESGFLPEWASPGHRDCMVGNNSASVVADAYLKGLTDHDIEALWQAVVSGANSRHPQIGSTGRWGYDYYNKLGYVPYNVGIRENVARTLEYAYDDWCIYQLGKTLGKPKSEINVFAKRAMNYKNVFDPEHKLMRGKNEDGTFQAPFNPLKWGDAFTEGNSWHYTWSVFHDPQGLIDLMGGYDSFNGMMDSVFNLSPVFDESYYGAVIHEIREMQIMNMGNYAHGNQPIQHMIYLYNYSGQPWKAQARVREVMSNLYSAAPDGYCGDEDNGQTSAWYVFSALGFYPVCPGSDQYVIGSPLFDRAVIYLENGKKIEISAQGNGEDKVYINELTLNGATSSQNYLTHEDLLKGAKINFEMSENPNKSRGTKKKDFPYSFSNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P9</accession>
    <name>A0A654E2P9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">recO</name>
        <name evidence="3" type="ORF">MARINOS108_20532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="26517" checksum="1DA124ED5FDF9EB6" modified="2020-04-22" version="1">MVTKTRGIVIKYLKYQESSIIVQIFTEQYGLMSFMVNGIRSPRSKRSIGYFQAFSLLELVAYIKPNRSIQRLSEYKYYATAHHIQQDIRKGTIVLFLSEILSKLLTHEQGESHERLFAFLSNAIITFDSLQSEIENFHLHFLLKMLPFVGLDVEDGTALIHSMELEMIEEDHNLITFISSIISSDYTEPVHGSGALRFKALELILNYYEHHTTQLGEIKSLKVLHQVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E323</accession>
    <name>A0A654E323_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD-like starch-binding protein associating with outer membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="27"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="371"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="498" mass="56197" checksum="D3B217860B46024F" modified="2020-04-22" version="1">MKKQRRYRLEKMLMGGLLIGGLLGCDDFLDEVPDNRVNLNSLDKSAQLLTNAYSVASPAFTEWMTDNVGFTTGVTIRQSQEQAYQWEDITSGPTEQDTPDFFWYETYNAIAHANEVLAVLDDFEVTSEEEEIRKDAIEAEAKLTRAYGHFMLVNLFGEHYTVESSGDGVPYVKTPETVFIETYERESVKKVYNEVEDDLLDGLEKVNDSYFGNSGKYHFNTNAALAFASRFYLYKGDVTRCIQYSTELLGANPGSFIRDLTSEEFQNAKSSITGYPQLYTSPDLPGNFLLMRKISLVQRPDFAHGPLSDFYSDLFAASPFPGTTDERENPAFVKGDNALLPVRFQNLFERSSLNSNVGLPYHIAISFSGEEVLLNRAEAYTIQNDLNGALADLNVFVARRYSGGNTTLTFENLRAFFGANNDPTFTDQLILLNYILFERRKEFIIQGLRWFDIKRYGISVTHELSDGSTISLSGDDLRRVLQIPQSAIEVGGLEPNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F3</accession>
    <name>A0A654E3F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD</name>
        <name evidence="5" type="ORF">MARINOS108_10550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="26339" checksum="C29A678275A44F4D" modified="2020-04-22" version="1">MSEEKIISIENVTKRFPVGDGEFTALKDINLEFRKGEFAGLVGPSGSGKTTLLNIIGSLDSPSEGRAIVMGRNISDLSHKESALLRNLHLGFIFQVYNLLPVYTVYENVEFSLLLQNKTSAERKKAVMQALEWVGLQDMADKKPSKLSGGEGQRVAIARAMVKKPDIVLADEPTANLDAKNAHAIIQTMKDLNKALQTTFIFSTHDEKVMSYLDRMIHLEDGKIDQDEHISHQMSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H6</accession>
    <name>A0A654E3H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">MARINOS108_20623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="20841" checksum="F348D9649D9226CD" modified="2020-04-22" version="1">MIYPIVLFGDPVLKKKAADIPKGASVKELIADMFETMYSASGVGLAAPQIGKSIRLFVVDDYPMMDEGEEGVRKAFINPQIIDEHGEEWAFEEGCLSIPGIREDVSRKSVVKIRYFDEEWNEHEEEYDDIHARVIQHEYDHIEGVLFTDHISSFKKRLLKGKLANISKGKVDADYRVKVPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L5</accession>
    <name>A0A654E3L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="32694" checksum="68443CB9E4580C0A" modified="2020-04-22" version="1">MGHRSKELVMPKEKVLITVKTYPSLSAKYDELVCTAGFKEDGTWIRIFPVQFRKKKYGQQYSKYQWVEIDLVKNTSDFRKESYRPVSHETEIKIIGEIKPDGDDWSERRKIVLNNVYTSLGKLIAEAKNKEIGTSLAVFKPTEIVNLEIKQVDREWSKEKLDKLNQLNLFESSDKDGKFEVVKKLPYKFSYKLKDSEGTSSTMMIEDWEIGQLYWNSLKRHGGDEKLACEDVRKKYVDDFARTKDLHLFLGTTKLHHNTAPNPFVIIGTFHPKPTTQTSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L9</accession>
    <name>A0A654E3L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="92" mass="10433" checksum="787B5F167CF421C2" modified="2020-04-22" version="1">MTDKEKIERHDTLTTLRTRIGSCFGTADGIFAGHPSDEQSAKELRKLAFDNKIKLIEIREIALGYLFGKGYVGPHIKEQIEKVDQLFGKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P4</accession>
    <name>A0A654E3P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hybrid sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="847"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1112"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="1261"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1362" mass="155570" checksum="18D972458E79997F" modified="2020-04-22" version="1">MLVLIFGLETKGQTEWPLQHVDKKSGLSNSAINAIYMDHLDYVWFGTWDGLNRYDGNEIISYKPIAEDEHSLSNNVVRQILEDKFGNLWIVTHDGINRYDHQLDHFHRYFNDLKDLPFLENNLKATLSEDSTLYISLVGWGVAQYNQQADRFEKIAIDEQVGQNIHSVGAFQNTLYLSNGEGKLYSHTYGKPVVSYDLEWSPKVWFHQFVSLNQRYFYLYQPSIDRLIIKELYQNRVANSFEINTQSAQITGVGSSSDGNRLLLGTDDGQLLEVSLADDQITHRSLSGMIPSLSKRKLKIFSLHTSKQGILWLGTDGDGVYKYLTKERSFYPISEGSPADGKLSNSIVRSIYIDPNNQLYAGTRSGGLNIISPDRSETRVLNKSNGLNGNTVLSITPDKHGNIWLGLDSEGVDMIEQRTGRILHFPRDFTNQPEDLYFGSVYKVFFDAYGHLWLGTSGYGIIYMDIEKTSTGAYRLNESYSISPDQKNTPGEISIRSNIVYTITSEEPNILWFGTRNGGLYRYNTLTRKFTHNLQADETSRYALSNNDILSLYIDQQNKLWVGTSGGLNQVNLSNFTVDQYTQSDGLANNTIHGILQDQSGRLWLSSNNGLFAFSPNANTFKNFNWTDGLLNYEYTDGAYFQLKGNHQLYFGGTKGIDIVDPNKTDTSTAFPRLAITDLLVSNVRIAPGDSTGILQTHIDLQKEIHLNYDQNFLSLRFTTLDYWHKQRCSYRYFLEGFDNDWNIIGKQSMINLTNIPPGEYQLHLNNSNENGDWNPHERTVLITIDPPFWATNTAYTIYVIMAVLSQIGLIQLSRNRSKRKKALEIERLKKEQAESIQKYKLEFFTDIAHEFRTPLTLILGPAVSLLEKTKEKPALHTPIQTIYRNSLRLQKLIQELIQFRKVEMGKEQLNIRAINIIAFAEELLQSFRQYALEKEIILTYEAPEELYAQVDSDILEKILINLVSNALKYTDRGGKVAIKLWAEQEKIYFSVKDNGMGIQEHELARVFERFTSLHHEKEEGSTNSVGIGLSLTKKLINLHHGDISVQSQPGEGTDFTFWLPASLPTQEQVAEDTVDHAMLTRLHEHVQAEFYHKDSLDQELINISLERHEHNLLIVDDNVQILNLLKDLLSHQYNVTSCTRAKEALSILASRKIDLVISDVIMPEMSGYELCEAIKTKIEISHVPVILLTAKGQMEERIEGLQAGADAYIPKPFHPDHLKVRIEKLISTREVLKKKFDAYTPHEKEFASFGIGAKDDEFFQLMDQFIKDQMNDPQLDAQHLANHLGMSKTSLYKKVRALTGQTPHALINQYRLKKAAFLLTNSEYNVSEIIYMTGFNSRSYFYKSFQEMFHCSPSTYGSEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q1</accession>
    <name>A0A654E3Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroE</name>
        <name evidence="2" type="ORF">MARINOS108_20902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.25" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28586" checksum="A0CA1820EC68468D" modified="2020-04-22" version="1">MKRYGLIGFPLGHSFSRGYFQEKFTRLGLTESHKYDLFEIEYLKDFPALWERYPDLVGVNVTVPHKENIRRFLDRLDSSAHKVEAVNVVKKEGNKLVGYNSDFFGFRQSMINYFQGNVTCEKALILGGGGASKAVEAAFLDLGIKYMVVSRDKHRGDLVYQDLKDDPTYVSKVDMIVNTTPLGMHPNLESKPDIPYDVIRAEQYLYDLVYNPEETAFMKEGRRRGARTKNGLEMLYVQADRAWEIWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V4</accession>
    <name>A0A654E3V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021908">
        <property type="entry name" value="DUF3520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022156">
        <property type="entry name" value="Uncharacterised_YfbK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12034">
        <property type="entry name" value="DUF3520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12450">
        <property type="entry name" value="vWF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024797740" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="248"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="605" mass="66690" checksum="6677CB1D358541AF" modified="2020-04-22" version="1">MKKLLLLLSMVMVFSLNAMTLPITGSVYDESGNPLPGVTIVEKGTTNGAQTDKYGKYSIQVNDTNSTLVFSFVGFQTEEIRVGKKQQINVILYTDVQQLQEVVLQDASSSSLRKRLNATGAVSRAAGPSYMVGESNPFHNTESYDAIEENIFHKSADKPLSTFSIDVDAASYSNMRRFLHMGQLPPKDAVRIEEMINYFHYDYEGPKDDKPFAIHTAKTRAPWNEDHLLVKIGIQGKKLAMEQLPPSNIVFLLDVSGSMNAPNKLPLLVSSLKMLTNELRPQDKVAIVVYAGAAGLVLPPTDGANKPAIIEALENLEAGGSTAGGAGIKLAYKVAKEHFVEGGNNRVILATDGDFNIGASSNGEMQRLIEEKREEGVFLTVLGFGMGNYKDSKMETLADKGNGNYAYIDNILEAKKVLVTEFGGTLFTIAKDVKIQVEFNPNVVQAYRLIGYENRKLNDEDFNDDKKDAGELGSGHTVTALYEIIPVGVKSNFTKEVDDLKYQSQTITGDTDELLTVKFRYKEPNKNTSQLIEQPLANDSTFDEDENLNWSATVASFGMVLRDSEFKGNLTFSKILTMAHQSVGVDEFGYRAEFIKLVNIANRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V5</accession>
    <name>A0A654E3V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025054172" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="4">
        <location>
            <begin position="126"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="482"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114073" checksum="5408CE6379C9C562" modified="2020-04-22" version="1">MRLKILHMFKSTNRLLLVLGLSVLSSMAYAQDIRVTGTVTDVETKEGLPGVTVLERGTSNGTITDAEGNYTLTLPTEYATLVYSFVGFTTQEISLAGQTRIDVALEMDIQSLEEVVVVGYGAQKKSVVTGAISSVKASDLETLPVNNISQSLQGRVSGVTIAANSGQPGEGSTIRIRGITTLNNNDPLWVVDGVVVDNGGINYLNQSDIASVEVLKDAASQAIYGARAAAGVILVTTKSGKSGRMNIDYNGYYGVSGPARKLNLLNATEYATLRNEALLADGKAPRFADPTSYGEGTDWQDEIFNNGAKRQNHELSLSGGNENSTFYFSFGHLEQEGIVSTEISKYKRTNLRLNSTHNLKKWLTVGENIGYAHNESIGLGNTNSEFGGPLSSAINLDPITPVVITDPTVAGAPPYSNNPVVRDAQGRPYGISDIVQQEMLNPLAYAQTRLGNHGYADNIIGNVFAEIKPIDGLTLRSTMGAKMAFYGNRDFTPVYYLSATNQNLDKARISGGLNRRLDWNVENTISYTKSLGGHNFTVLVGQGAYKDNMTYSFGVTKANIPVDNYDDASFIYNVTTDDITASAGEGVIHTVSSLFTRLNYNFDEKYLFTAVVRRDGSSRFGANNKYGVFPSASIGWVTSNEGFWQRNQIINFLKVRGGYGVVGNDNLGDFRFLSTIGSGRNYTFGNGDASINGYSPDAPANPDLRWEQTSQLNIGFESTLFNDFTLNADWYRKETTDILRTKPIPRYTGVIGNPYANIGDMENMGVEIELGYRKSLGDVNLNVSANASYVENKVTNLGDVEFYNTSSVQNMGTMARMAVGQPINSFFGYERLGIFQTQSEIDAYVNDEGGLIQPDAQPGDFKWADRDGSGDIDPEDRTFLGSPIPDWTYGVNIKLDYKGFDLLVFGQGVQGNQIFQGLRRLDINAANYQTAALGRWTGPGTSNDFPRLTDDDPNKNFQYASDFYIENGSYFRLKVVQLGYSLPQSLLDNIKVRKARFYVMAENLFTFTEYTGYDPEIGGGSFGIDRGIYPQARSFMVGLNVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W8</accession>
    <name>A0A654E3W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c-type biogenesis protein CcmF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="4">
        <location>
            <begin position="95"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="CcmF_C" evidence="5">
        <location>
            <begin position="336"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="839" mass="94381" checksum="C53C0EDE39E317D3" modified="2020-04-22" version="1">MIHYFPGNLGHLLVILAFVSAIVATYAFAKNINDNEQKWTRFAKGAFYVHAIAIFSIVITLFVMISGHMFEYHYVYNYTSKFLPPYYQVSSFWNGQEGSFLLWMFWNAVLGLILIHTNKSWRPSLMAVFTFTQVFLVSMIMGVVIFDVKIGSSPFILLRDVVSDAIFRIQPDFIPEDGRGLNPLLQNYWMVIHPPTLFLGFATTVIPFAYAIAGLITGKYKEWIRPALPWAQFSAAVLGVGILMGAYWAYETLNFGGYWNWDPVENAIYVPWLVMVAGIHTMIAFKKSDAALKASIILILSTYVLIVYSTFLTRSGVLGNASVHSFTDLGLSGQLLIYLFVFTGLSIFLAARAWKNIPESKEETSAYSREFWIFMGATVLSLMAFQVIIPTSIPVWNEIVEAFGGSSNMAPPADQVGFYTQFQLYFAILLAVLSGTGQFFWWKKIDGKKLKQELTVPVMLSLVVTALIFILAKVQNIWYLLLLTASVYSIFANGKILISVARSNIKLSGGSIAHIGVAMMLIGILFSSGYSKILSKNNTGLLWSKEFPDEVNQNNLLLFLNEPRQMAGYSLNYKGLRKLTKNSGYVDINDIAGAISPLQLVMGNDSRSSTDVALKKGDTIAIINPENSYFEIEYSKLDGSKFTLFPRVQINETMDMIVYSPDISRTLKADLYTHVRTFPDPEQTVEWSEIQEITVTPGDQFFINDYVARFIDMVPVSRIEGVEMGPSDVAVKAIIEIEGEQKTYTAEPIYIIKDKMAGRIPDVVSDLASRITIQSIRPEENSFVFGLSTTQKDWIIIEAVEKPWINILWSGTLLLVIGFGIAINRRYTEFKKMRDKGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y7</accession>
    <name>A0A654E3Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1502" mass="168566" checksum="E32BB978C5F79C71" modified="2020-04-22" version="1">MKGKITFRSAVVLLRKLIFWSITGIAIFLVILILLLQTPFLQNYLANEVLSLINANTRQTAKFTNIKIKWFDFVEIKGLEVKDYQDNVMISASTIQVDYQLDHLLVEGDLWFDQIYLRDGALHMKKYEDTLNLNLIEFINDLRALAPKKQDTVSKASAPKLSLGKIRLDQFQFSYDNRLNDSLPQGKFDYGHFLLEIPGATFADFTIIRDTIQAEIRSLAARDPATGLTVEKLQTMFMLNSHEIDLSDLVLETRHSIIRDHFGLKYSDFSALSDFTNSVALDVNLVDARISKHDLAFFVDLPTDDFEVNISTQISGPVPRLSLSNLQLDFGIGTHLEGSFDFMGLPAIEETFIDARVKEALIYPQDVQVFTTASLKELEELGEISFSGRFLGFTNDFVANATFDTNEGKVYSDLNLKFPKGWEEASYSGKLKLDHFNVGKVIGDTMLVGRVNLEGKIDGQGLTQKNAKFYLDAEVFRSEIFGYEYEHIKANGQFSSQFFEGKLEITDPNCKVLTEGSVDLKQAPERVKIYSEIDTLDLFALGFTRTKWRINGRVDADLSGLNLDSLQGSVRIDDLGLVWSDDSLKLDSVKLNSSLIGRQRRIELILPELDVQLEGDFYFSQISSDIETMASELEAYFSPDYSRDPEKVSADQPVNSYSIDFQVRYHDISRYTNLIFDKDFYLSPKGVFEGTYYQRKNATLSIFAEIDSVYFNGFSFNQNTIDVNLSKDLDSAGIIASVFIDSQKQAWKDNPPTKNLSIEAVWFDDKINFYTSIAQPENNSSADINGEMKLSDDRLTFNFLPSKLVAFGERWYFNPYNKITLTEKELVFDRMELYQNDQSILLKGIYTDSAATNLNLSFKNFDLKALGALLPVSLGGVLDATVDLIREDIQSPFILDSDLNVNAFELNEFVVGNVAGRSKWNPGRRGLEIDFGVQREAINTITIAGMYIPGDSLEQLDIKAEFNQANLQLLDPFLQGLFSDIGGFADGEIAITGSTRYPVLNGSSSVSNGRFTFDYLGTTYSFDGDLSFDNKAINFNGIKLRDRDDDRATLSGAIYHRGFRELEVDINMAVRDFQLLNTTASENSLYYGTANATGDISIAGPVEDLIIKAKATTEKGTKLFIPLSESSEITQKDYISFVDFSDTTNTFNIDEIVKNSISGIRLDFEIDVTPDAYVELIFDIRTGDIIRGRGNGNLKMFLDTNGEFELFGDLSITEGAYNFTIPALGINKEFTVSAGSTISWYGDPYSGILNLNANYRQLASFDEFDGTADASAVSQKYPVLVVLKLQGEMLSPRIDFEIKLEDSQSSPTSDVQRALSVMNNNEQELKRQVFSLLILRKFYRQSSFNVGGSDVGGSLSEFLSNQFSYFISQVDENLEVDVDLSSLDANAFNTFQLRLSYTFMDGRLRVSGGGAIPSSGADDPSTNDVIGDWSIRYLLTPDGHFRVKAFSKTEQIANDLQRETGVSFQYIKSFDDLRELLTRTREAAISSKPKDMSKERAANEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E406</accession>
    <name>A0A654E406_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="80" mass="9528" checksum="0C37E3A6871C8B81" modified="2020-04-22" version="1">MARSQNSFIKKQKEKKKLQKKKEKQEKKKERQENNDKGGTLDDMIVYVDEFGNFSDEPPEPPKAKDKKKDDKKDEKKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E461</accession>
    <name>A0A654E461_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="311" mass="35765" checksum="60BDC6765D2C23AD" modified="2020-04-22" version="1">MMNKPLVSICCITFNHEEFIRDTISGFLSQVVDFEIEILIHDDASTDHTAHVIQEFEKKHPGLIKPIYQTENQWSKGIRASPTYLWPKAKGKYIALCEGDDYWTDPSKLQQQVDLLESNSDYIISCHNVLERRDQELNLFNSEGKIVKEEFQIEDLFSPWFIPTCSVVFRKPPVIVLPDWYLNSPHGDLGLYFTLMRNGGKIHYNDTPMAVYRRHPGGVSSRFTKGKLILSLSYLYTCVNISFDNKYTDAATAGIEEIVDLMNADKYLRVLSDPQKIASVTPFRGLMKALIIKMRVYLRKIGLRLSRKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E490</accession>
    <name>A0A654E490_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-(Ms(2)io(6)A)-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045301">
        <property type="term" value="F:tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07910">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010386">
        <property type="entry name" value="tRNA-Hydrxlase_MiaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42637">
        <property type="entry name" value="PTHR42637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06175">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020736">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="23329" checksum="A4457D14DCC0BC59" modified="2020-04-22" version="1">MMEDHKTVLGLKLPTDPRWVNIAEMQIEDILVDHAYCEQKAASSCISLIIQYPEKSELVDVLTPVVAEEWAHFERVIEQLKKRGYALGYARKDEYVTALNKVLNKGGSRDQQLVEKLLMNALIEARSCERFKLLWKNIADEELQTFYYELMVSEAGHYVNFIELAKVYMTEEYVKARWEEILVAEADIIRSLELRGDRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H8</accession>
    <name>A0A654E4H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="747" mass="83276" checksum="CBD41ADC352DBA65" modified="2020-04-22" version="1">MIKKILSITAIMLIVFTVTGQHLDVREEVYLQTNSAFMLTGETLYFSAFVRSADTGQPSPLSSILYVELVGSDGKPVFQKKIHLTKGRGNGTFFLSSLVSSGRYQLLAYTRWMKNFQDYFQTPITVINPFEEYPQPAQNEELSVSFYPEGGVMVAGHENDLVMKIDQGNPAGIGGRVVSASGEKIADIPASQIGLSHFTIPVKEGESYQTILEDQAGNFLFFDLPKVTSDGATIQIRDAGHSYGITPIGPSSPGILTLSIHDGQNAVFQQTAVINARISLPKTKLVAGTYLVTLTSGTGDQLASRLLWHPGSLREQRSEGMAAYHTRSPVTIPLEFDDEADVSVSVRRMEMGHQPTSAIHQALFGKINKSWSLSVQETSDWKTMDNSLMASEWKGPKTEMPKTVKWLPELRGELIVGALNYEAPSEDKPPFVALSISGDDYQLQTAQVDEYGHFQLLINPAEGPRKAYISVLGSTNEVSFQLEGQFLQAYPPFDYSLPYLDSAQVSALVERSVRNQIENAYYELKKDSIVPQTYWNPQFDYDISYVLDDYNRFPELYEHFIEFIPEVMARKNKTRSKIKVLTKYVTPGSLDPLLLIDGVPTTAEEILDFSPYKIESIGIINNRVFVGPLVADGIVSFHTFERNLHGYKPGPNSLNIQYNGLDPVQQFSFPSYEDADQRLARIPDYRQQLFWNPSLTVGENGTKELEFYTGDTAGTFEVSIDGYDKNGSPISIRRYFKVQSTNPPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R4</accession>
    <name>A0A654E4R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M43" evidence="1">
        <location>
            <begin position="163"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="334"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="908"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="984" mass="109586" checksum="D5D9FB6BDA87CA0F" modified="2020-04-22" version="1">MRGLLLFLLLFSFGISKGQERCATNQLNANVQRTEVQSDFEGWLKKRIQEKKAQQAVSPRRATAYQIPVVFHIIHDGSPVGSGSNISDDKILEQLQIINEDFNRTNADASETPAEYQDVAADAEIEFILAKQDPEGLPTSGIVRLQGSKSTYSPSEDALLTSESYWPQNDYLNIYVTDLSQGNLGYAQFPFSNLPGIASELENYKSTDGVVLDYAWTGNNENTGSFDSKGRTATHEIGHYLGLRHIWGDGGCGVDDFCEDTPPASGSSTGCPKNKISCETKDMIQNFMDYTDDVCMNLFTTCQKLRMHTVLEESPRRASLLTSPGLKEPVLTNNDLGIRSAIAPTQSQCTSMVTPGVQVRNYGLNPITAFKVSLFHEGVLQETLTSNVPLTTGETTEINFTPLFLDDQDANELTFVVTQVNGGPDGNDQNNSLTVTIAPFLPKVVPFFEDFEESTNYYKITETGAQSAWMYTTAPDSTPSNQAAVLPFYNQTANFGYQDFLITPTLDFSALTSVQLDFRYAYASRFSENLDGLIVLVSTNCGQDFLLQNMVFERYGKNLRTAGTSDFSFIPDELSDWESVNLNLTKFAGEEQVQIAFAGVNGGGNNIYLDNISVTSANLLAYDIGIKSVENLPVVSCEQSAFPLVEIKNYGYENVRDIEFQVEVNGVTFMEEFHDLFLPSGHSETFMVNTSDFMTDGSNEFIFTISQVNGRQDEQASNDQKIFYGLVNDTEDAIPVQETFENQSWIVVDPTGVPLFEVLRVNGDTVLASMSYGNETVSKSYLISPTLKTGPYNQGAIRFDYSYGQRTGFNDNLKVLLSLNCGKTFEKELLSLNSEQLAVKVSNTEWVPESREDWKTAFIDITEYMNWPELRIALVFSNGNGNRLYLDNINVLTTNDPGLPEFQNQVQLYPNPATTEFNVAFNLPERQKVNLQLIDISGKVLFDQDFSNIINQTINLKAPSQSGFYILHVTGQEISYTKRLFIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W2</accession>
    <name>A0A654E4W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5562" checksum="BA74B55816550EE5" modified="2020-04-22" version="1">MFHLNPNYDKDIYTFVDVDECGRQALCAGYVYGNVSASVSRISSQWFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W7</accession>
    <name>A0A654E4W7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="404" mass="45435" checksum="832C8180B669FCF5" modified="2020-04-22" version="1">MKHHQQILKSMVLLWMIMVLCYCKPGEEPSEQPPMVEEDTTAWVIEHAQPGAPISHIRWGEPVKVSHEVFGAEYPRMLQLGEDTLFLAYHGGDEQNAWDNIYLRKSFDRGATWSEEEVLMADNDPNYWGFANPEFLELRSGRILMAFTGRGRPDDNQHDNIQFMYSDDRGTTWSAPRIVALGRSWEPAMVQHPNGDVLLFYSSEARWWQVVPADQTQQEILMVTSKNDGGSWSLPKSVAYTSGMRDGMPVPLVLKDGKGIAFAIESVNNRDSPWILRSSLSARFQTPGDISKRLAAPKTTVNFGGGPYLVQLPTGETILSCHDTGDRDIGPDWKRNTMYVLIGDAEANNFSNVSYPFPDLPADEGAFFNALHVLDEDTVIALGSRYFADGHTEVHWVTGEIVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E532</accession>
    <name>A0A654E532_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22561" checksum="88789A17097685FE" modified="2020-04-22" version="1">MKKLLFILIPVAAVAIIFYSLSGNSDEAYISKVADTRAERVRFLKSSEQSPFTQFDLKYEPLSFFTIDPSYKVRANLERIQSPSRVMIQSSDGTSAPYSKFAYASFKFQGQSLKLLILKPAGFGALPNTYFTAFADDTSGESTYGGGRYLDLQIGKSDNIEIDFNLAYNPYCAYVSEYSCPLPPAENVLPLRIEAGEKDYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E566</accession>
    <name>A0A654E566_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter (DMT)-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="145"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="304" mass="34097" checksum="5144021FB579DD02" modified="2020-04-22" version="1">MTQETKDFAFLHFIVLIWGFTAILGVLIDLPSVEMVFFRTLLASVGLLAIVYFRKKSFSFQQRKDHWVTLGTGALIAAHWILFFLSARVSNVSVCLAGMATCSLWTSFLEPLFNKRRIKPYEVVLSVIAFVGIAIIFNVEFDYFSGLILAMVSAAIAALFTVINGKLTKREDPFVITFYEMIGATLAIALFFPIYLSFEGIDSLALSPTLSDWGYLIILALVCTVYAYSYSVKLMKRLSAFSVNLTVNLEPVYGIAMALVFFPEKEQMTSGFYLGTALILASVLIYPLINRRLKRKALNTDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E579</accession>
    <name>A0A654E579_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13541" checksum="0760E7C06B5D15A1" modified="2020-04-22" version="1">MSEVLVRREEMIFETENGSLSQSDATERFQLAFHQEELSFRVCELITFKRKLQAIDLPAMLMSENQDVEVLHMPHCDRLFVLTIQNILELKELLAGAFAMLELNSVIHRQLVRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E596</accession>
    <name>A0A654E596_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">icd</name>
        <name evidence="6" type="ORF">MARINOS108_50049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="593"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="609"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="750" mass="81242" checksum="4D27092841A46D70" modified="2020-04-22" version="1">MTQETQEQMAKQGTIIYTITDEAPALATHSFLPIIQAFAAPAGIQLETRDISLAGRVIASFPERLTADQRITDDLAELGNLAKTPEANIIKLPNISASIPQLVAVIKELQSKGYNLPDYPAEATTEDEKDIKSRYDKVKGSAVNPVLREGNSDRRAPRAVKEYARKNPHSMGAWGADSKSSVAHMKDGDFYGSEKSVSVSEPGDVKIELVEANGAVTVLKEKTSLKAGEVIDASVLSKNALRAFFEGEIESAKKEDVLLSVHLKATMMKVSDPIIFGHAVSVFFKPVFAKYEATFKSLGVDANNGMADLLAKIETLPVAEKANIEADIAACYAARPELAMVNSDKGITNLHVPSDVIIDASMPAAIRTSGRMWGPDGKLKDTKFIIPDRSYAGVYAAVIEDCKANGAYDPTTMGSVPNVGLMAQKAEEYGSHDKTFEIPGDGEVRVVDAAGNVLISHQVEAGDIWRMCQVKDAPVQDWVKLAVTRARASKTPAVFWLDENRAHDAQLIQKVNQYLKDHDTSSLEIHIMSPVAATKFTVERIRKGLDTISVTGNVLRDYLTDLFPILEVGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFVEEGHLRWDSLGEFLALAASLEHLSIADSNPRAQVLADALDAATGKFLEENKSPSRSVNELDNRGSHFYLAMYWAEALAAQDNDAALRDLFAGVAKELKEQESVINGELLAAQGAPVDIDGYYKPSEELTSKAMRPSATFNTILDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D2</accession>
    <name>A0A654E5D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017208">
        <property type="entry name" value="UCP037442_abhydr"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037442">
        <property type="entry name" value="UCP037442_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="33160" checksum="1434A0219C9523E4" modified="2020-04-22" version="1">MHKAEGFQIISEDKTKISATLFSGDAKSAHLIIVSPAAGAPQRYYKGFADYACQYKEFDVITFDYRGIGDSLHSSVKDERCKMSDWGDKDLNSVIAWANKKYDKIFLIGHSVAGQIFPKAANNGRIRSAYFVGSQSAYNGHWKGFWWLYVLIFWYILIPTTVAIYRYLPGWTMGGKIDIPRNAALEWRKWGTHPQGVLQGSKEMAQKFDAVKIPVHFVNIQDDKLLAPSAATQALMHYYRNAVTTFQFIKPKDLGFEKIGHFGFFKKKFARKLWPMPIFFFTQFLNKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5H8</accession>
    <name>A0A654E5H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="293" mass="33515" checksum="D01D99F543FFDD87" modified="2020-04-22" version="1">MRYQVTHITDYIYQNTASLCHNIMVQLPKDSECQTVEESSYEIDPEPSFLGERKDFFDNQYLYFSIERAHKKLTVTSRTRVTLKSPKWMGVDPASTSPWEEVVKWLRTTDALNDIRQFYLESKHVHFVEGIKAYTLQSFTPGRPIMEAMMELNSRIFHDFSFTPGFTDISTPLEKVFETKKGVCQDFAHFALACLRSINLAARYVSGYIETLPPPGKPKLVGADASHAWVALYIPELEWVEFDATNNLLVDDKHVRVAVGRDFADITPLKGIVYSVGKQTMKVSVDVRNLDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5H9</accession>
    <name>A0A654E5H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5269" checksum="BDCAAA1626055B9C" modified="2020-04-22" version="1">MVKAVSRQVGFDPDECLLELLAKGCKEGLKKRAYVFKFRKHVSNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5P0</accession>
    <name>A0A654E5P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="274" mass="31121" checksum="8CD8C00A57699D6E" modified="2020-04-22" version="1">MMRYCFICIFLYGYFVSSGQDVLWGTNAVETREDVLKSALSFERQAFEESDLSRKGFFLLQKSYCYKKIGDYQSALDILNRVKIPSRDTLNRALKYEKILLNYLLGNYQRSFDELLKYRLSQGTSQGEVDGDILILEILNLIGLNKWEEAKELTLMNADHLGTDSEQVEAFFSGRLKPKNPDKAYTLSLFLPGVGQMYSGYFLKGVLSGGIQTLLVGFSAYSLHQGYFFTGGMTGVALFYTFYLGGARHARELAVAKNKERAREISLKFMKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5U1</accession>
    <name>A0A654E5U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016786">
        <property type="entry name" value="YdeI_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021308">
        <property type="entry name" value="UCP021308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="23778" checksum="4B6A91E3EDBE76E3" modified="2020-04-22" version="1">MNKDVNTYFSDGCGRCSFYATPQCKVRNWPKELEQLRRIALDSGLNEESKWGVPCYTHQGKNILIVSAFKEYCALSFFKGSLLQDTYGLLEKPGENTQGGRLIKFTRLKEVLDQETTLKAYIYEAIEVEKAGLEVTFKENPEPLPEELQLKLQENPDLKAAFEALTPGKQRGYILHFSAPKQAKTRISRIEKCIPQILEGKGFFDRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E701</accession>
    <name>A0A654E701_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative FecR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="259"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="37514" checksum="1EBEDBA7967368F1" modified="2020-04-22" version="1">MDQIILKYLNNEMNIDDQHRLSKWLDEDPKNRQILTKIELYWKSSDPSAQSAKNRIWLQLLDEIDLSAGYHGQKESKKFHVTWYHMAAAVALLITSSWLVYNFWSGSNLSNSDIIRVVEKVAPVGKKLELQLADGSTVKLNSGSKISYPEVFEGNSRQVVLTGEAFFDVVRNESTPFIITTDNINIEVLGTSFSIQAYEDESFSEVFVRSGKVRVSDPSGRSFVDILPAERATYDKRENILSRSSIENSAAAFGWMDGRLVFEDEELAVVFRRLSRWYGVSVSYDKIALKEKKITINCKDCSIQELMESLSYNYEFDYKINGDLITIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7D4</accession>
    <name>A0A654E7D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22790" checksum="54AF6DB75972CA98" modified="2020-04-22" version="1">MMDENSCLQAIAQGSEEALEQLYHQYADRVYNTLISYTKNAEDAEELLQDVFVTIYNTASGFQYQSSVSTWIYRIAVNKSLDFLRKKNSQKRSGIFTSLYVKDSAELKHESADFVHPGVQLENQEDARLLFRAIDTLSDNQKTAYLLTQVEGLPQKEAAEIMNQSPKAVESLVQRAKANLKQELEKYFPERGKSKNSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7J2</accession>
    <name>A0A654E7J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024934241" evidence="1">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="19924" checksum="B898EEA61B4EDBEF" modified="2020-04-22" version="1">MKQFKTFSNVLLAMAFIWLTSSGLMAQDKDKNKRPSPPAQVTNTVNGTTVTIDYSQPSVKGRTIWGDLVPYGKVWRTGANEATWIEVSADVKIGDKTLPKGKYSMFTIPGEDEWVVIFNSTWDQWGHYNYDKSKDVLRVKATPLKSAKFSEQFTIGLSEDGVVNMDWANLSARFDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7Z3</accession>
    <name>A0A654E7Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="21686" checksum="1F1727866CCFE843" modified="2020-04-22" version="1">MVANHSTYFMNHQSVCEEQTFHQVHSDHSTSLRNFLFYKFGDLEKAKDFAQDAFIRLWDNCSKVPFEKAKSYLFTIANRLFLDDVDHQKVVLKFQYRQGTTEKQMETNPEYIYQHDEFKERLELAVSELPDKQRAVFLLSRIDKMKNKEIAETLDISLKTVEKHIASSLQNLKGKLDELTNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC60</accession>
    <name>A0A654EC60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="8902" checksum="9C10D74136A8BCBC" modified="2020-04-22" version="1">MIKTFTENDLVRFLYDELNENEREVLEKALLTDSHLRSELDKLQAVKKDLGKVSFSPSKSSVDKILNFSKGYHKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT55</accession>
    <name>A0A654DT55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="PTHR23422"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025019295" evidence="3">
        <location>
            <begin position="26"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="547" mass="61003" checksum="54FC9D5B7001CD7D" modified="2020-04-22" version="1">MKQVSRFLVVALVISLFGCGPQKQAQSTDEAPNEIMKAKLEDYKKVRLTADLTALSEKEKKMIPKLIEAAQIMDGLFWYEAYGQKDSLLSTIEDEATRAYVKINYGPWDRLDNNKPFIDGVGTKPPGANFYPTDMTKEEFEAADLEGKASLYTFIRRDENGQLIAIPYYEMFSEEVQRVSALLLECADLAEDSGLKAYLKHRAEALLTDDYQPSDMAWMDMKTNGIDIVIGPIENYEDALYNYKAAHEAYVLIKDRTWSDRLSKYAAFLPELQRGLPVPDAYKAEEPGSDADLNAYDVVYYAGDCNSGSKTIAINLPNDEQVQLAKGSRRLQLKNAMRAKFDEILLPISKVLITPDQQQYITFDAFFANTMFHEVAHGLGIKNTINGKGTVRAALQEHGSALEEGKADILGLYMITQLHEKGELEGQIEDYYTTFMAGIFRSVRFGAASAHGKANMIRFNFFNEYGAFAQNEDGTYRVDFAKMKEAMDALSELILTLQGNGDYAGVDALVKEKGTIGAALQADLSKLEAQDIPVDIVFEQGVEVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTR5</accession>
    <name>A0A654DTR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRPBCC domain-containing protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="33646" checksum="77393A779B48158C" modified="2020-04-22" version="1">MLDYSDFQFRNDEDSPDYFLWQVFSDWQNGKNLLIEEYNITSPQMTILTAIYWLLQNERDTIQVAVADAAKMDKMTTSTVLRTLQKKGLVTRTEHASDTRAKTVHLTKRGLETTVKSLKRVNNFNLDYFSALGDSKMTFINLLRKLLIINSMQTEFKSTYQTTIKAPIEKVWDALINPEIVKKYFFESNQETDWKVGSPILWTGEYEGTPYTDKGVVLEFSPNKKLSYSYLSSWSGLEDKTENYLLVTYQVKPIEAGTELKITQSNYDEDKAKHSSENWAVVIDGLKKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTU9</accession>
    <name>A0A654DTU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="18436" checksum="938BDA5530C84952" modified="2020-04-22" version="1">MELGTTIIGLGATALCIVPFVLMRRSTKKKEHELINGLKVIAASYNREVSIYDCGIDFAVGISAARDFVFFVKIRNEEMLEQCIPLNAIQKCRIDSTKRSIKTKGGHESVTDKLELTFLPIDKSIAASQFEFFNSEDHFQLNGELQLIKKWEALINEILSGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU98</accession>
    <name>A0A654DU98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="39053" checksum="5F92285EC47FF319" modified="2020-04-22" version="1">MMASTPREQGFRFPAEWYPHRATWLSWPHNENSWPGKIKTIYQPYCEFIKAVATGEQVCINVANDKMEKQARTYLTEVGADLSNIAFYHHPTNDAWCRDHGPAFVIKEGEKAVINWGYNAWGEKYPPYDLDNQIPGLVAGKLGLETFNPGIVMEGGSVDFNNQGIILTTTACLLNKNRNPHLNQSQIETYLKDYYGAREIWWIGDGIVGDDTDGHVDDITRFVNDNTVVTVVEPNTADENHAPLQENLELLKTFKMPDGSPLNVVELPMPKPVVYEDQRLPASYANFYIANSCVVVPTYRDQKNDPLALEILKTVFTDREVIGIDSTDIVWGLGSFHCLSQQEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUE5</accession>
    <name>A0A654DUE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanases superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="2">
        <location>
            <begin position="796"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113378" checksum="D537D8319AE074EA" modified="2020-04-22" version="1">MKYGMFLISCLVSLTVSQAQQQISIPRIDQMPDWPQPYQMRDWKQVAVKYDSLVFARTSGEHMPFLSVGSAGVNYPELQPIFMDSYVGSSSHGTQREAINIIPAVIGATLVGADKTTQFGTDWVTKVRDFYNLKNEELVYLNGPSDRSGHDWWYETMPNVFFYQLYDLYPDTPGFAEHFLSVANRWADAVEAMGADIAPWKVPYMNYRAWNLKEMKPLNEGVKEPEAAGAIAWLLYQAYHQTGDQRYRHGAEAALDFLNELTNNPSYELQLPYGVLTAARMNAELGAEYDLEKMIGWCFDRGDLRGWGSIVGSWGGMDVSGLIGEANDQGNDYAFIMNGFQQAAALAPLVKYDKRYAKAMAKWILNVANASRLFYSTYLPENQQSDYDWCTTNDPDAVVAYEAIKELWQGTALYARGDSKDAGWASTNLGLYGSSHVGYLGALLAPTNVEGILTIDANITDFFVDAPFPTYLVYNPHGESKQVQIQVGDQAKDVYDAISETFILNEVTGTSEVTIGPGEVLLISYVPSGGTVEEKQGQLTANDQVLDFHYGYDFSGKLRIKALAATSDPAESGVADTIYCTVQGESVQYEWYVDDQLQTSDSAAFIWTPGATGAASIRAVVSANGRMAQDSLLLDVVALIPAYPVIDTLFADQKWYKPGDVFWVDAEVRDPKGLDLTLDWTVDHATILEQNESQIKVQAPSEGGVISITLSASNYDKQTQQTLQVLITKDAILTAPLVHLPLNGNPQDVSINQFSTSLQGGSYVAAPTAQAGEVLVLAGQSDELVIANQPALNFGDAVTISFWAYFTDFAQERFVISHGGWEQRWKVSTTTDQRLRWTINTTAGIKDLDASVILEKSKWYHFTVVYGDGAMQIFSNGELDTFVGHTGQINAAEVGVSIGKRLPGDAQYYLKGRVDEIRIYSEPVGPTQAALLPEEWYEQPPLSIRQERFHLYPNPVREGGFVNVQLGSMQHVILTDMTGKRVAELKATSTSDGTFRIDLSMIKRGVYLLYPVQATGDCYKLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUG3</accession>
    <name>A0A654DUG3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024824455" description="PDZ domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="392" mass="43613" checksum="7CAEAC2653BC0913" modified="2020-04-22" version="1">MKRIFLLLTIFGSFGLSAQKLITSTPFELFGNHLFISLSVDDSEPVDFIFDTGDGLAVIDIDLAKKLNLKTDHQKSKTSAQGTISGALIAHNKVEIGDVKVNDIELYTTNLRHLERTIGRNIDGIIGYDLLKNYVVELNYDEMVMNLYQPDGFAYQGAGEAFKFKLVNYIPTIEASVTLNNGESYKDYFFINTGAGTSMDFNTFFATKHDVISKTGNHYSYPVAGLADQETMHYEGRVKKFSVGSFEFDEMPVGISQAKHGIQHNKKVAGILGNNLLQRFNITFNYSTSTAYFEANDLNKQPFLVNASGLNLQYGEDLQKLLVHRVFEGSPAEAAGIKENAEVISINGTDIGTYTLPEIRKMLKDIDNKTVTLEYRQEGVTSEASLNLEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN0</accession>
    <name>A0A654DUN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37881" checksum="B934594C94E94262" modified="2020-04-22" version="1">MSKKLFVLIWVVLGVSLAVISLRYKSRTEALVAVVESQVTAVSYQKPVIIERIYVIPGQEVNVGDTLVVVSRPDLNLDIERKTNEQERVVSGIVQANQDYLSKKELLTIEREGKINRLISERSELQTELNQQTRIRQQLSGGMLSTTADSLKIIQLKAIETEISDLKRFYAQEIQRQQLQLNEQLEIQKKEIELIEKELQALYDERNTLVRVAKFQGIVGTLDVHLDELVPAFKTLLSIYESHPSIIKAYINERFTSMVKPGDTVKVVSENRLYSITGYVKELGARITAYPGKIQSPTANTVSYGQEIFISIPTDNSFLNGEKVFVYPQMSTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR7</accession>
    <name>A0A654DUR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="15844" checksum="E5014D3005AA5878" modified="2020-04-22" version="1">MLESIWVSNHIQRPVIKAYNNIFAESLIYSGKPKGDPNRIALPISGDDKNANEIVAMLIDTSGFDSLDYGVLKESWKQQPGSPVYCTDLTLSQLQKSLAIASPKGLPKKRELGLKYILEDGHEKWMDTVLHNRTIYKSVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ4</accession>
    <name>A0A654DUZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase subunit IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="107" mass="12005" checksum="6316BB58DD34D663" modified="2020-04-22" version="1">MELETTEVQVIPEDKSKINKILKVALILGVVTAIEFVIAFTVPAGVFRTSVFIILTIVKAFYIVAEFMHLGHEKKSLKLSILLPIIFIVFLIFILMYQGAAILEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV04</accession>
    <name>A0A654DV04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine transaminase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohydroxythreonine aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_10932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="7"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="357" mass="40105" checksum="C714AC340B7FB9E9" modified="2020-04-22" version="1">MQHKIYFTPGPSQIFYTVNDHMKEAFQKDIMSISHRSATFQNLFAEVKADLKSLLNLPDHYDVYFISSANEIWERIIQSLVGNASHHFVNGSFAEKFYQFATDYKKESTITRMSDGQDFDNLEVPENTELISVTLNETSIGYAFNANSIYQLREQHPDKLIAVDGVSAFPAVPFDFSKVDTAYFSVQKCFGLPAGLGVWIVNPTCYQKVEKLRKNGVVTGSYHDLLQLKASGDKNQTPETPNVLGIFLLGKVVKDMLFRSAKLIQNDTTYKAALLYQAIEKSSVLSPFVARKTNQSKTVVVAKCEGGNADILARFGEQGWIIGKGYGSYKSDHIRIANFPVHSKEQIEQLSDYISKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV54</accession>
    <name>A0A654DV54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoamylase-like" evidence="2">
        <location>
            <begin position="437"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="668" mass="74070" checksum="D911EFB7C56B832F" modified="2020-04-22" version="1">MIQKGMHVVAPIILVVLFVFSLAGCGDDSTGGVTPATMQLTALRIGTSNLLANPEAPQPVDKSIILSFSHTLSESTVSSSITLTDENDQAVELAFSLLDSDKTISITHSEELAINSTYTLSISKDIKGAEGETFQGFQVTFLTENPPMVLSSVTIDGVSPDQNQRIINISRLPVFQLTFSDPLDLEELKDNINLSGGSIPATFNVTNGASDSTFTMTVTENLEGYERYSLFISSALTSISGKKFESYQLPFYTELDSSLKFPEISDEALLTKVQEQTFKYFWDFGHPVSGLARERNTSGETVTSGGSGFGLMGIIVGIERGFITREEGVARLNKIITFLDEESDRFHGAWSHWLNGTSGKVIRFSSDDDGGDLVETSFMVQGLLTVRQYLDSIHPEEADLIARINSLWEGVEWDWYTQDGQDVLYWHWSPNVGWQKNHKISGWNEALMVYVLAAASPTHPIDQEVYTAGWARNGAMVNSSGASYYGYQMDLRSDKGGPLFFAHYSFLGLDPRNLMDQYANYWNQNVNHTLINRAYCMANPKRFVGYSAQSWGLTASDNHEGYNAHSPDNDLGVITPTAAISSIPYTPEESMEAMRHFYYILGDKLWGEYGFYDAFNISEGWTASSYIAIDQGPILVMIENHRTGLLWNLFMSAPEVQSGLDKLGFSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC6</accession>
    <name>A0A654DVC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4341" checksum="9435E9B3D821FAF3" modified="2020-04-22" version="1">MFDLFVCITYSVVCSKTNGEIYSLIVSSHEKLKSITNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVM5</accession>
    <name>A0A654DVM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="1">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="2">
        <location>
            <begin position="217"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="40907" checksum="3A7FBC98B693592C" modified="2020-04-22" version="1">MKIQELIYDGEAWQKQDVKTGFSPQLVLLFASKGTLLQANCYESLKRLYPETPVLGCSTAGEILGERVYDDSAVATAVQFDSSTISYASVNIDSAKESFDKGVELSNMLPKNDLKNVLIISDGQKVNGTTLIEGLKKHIDQDVVVTGGLAGDGPNFEETLVVANDHPKSGVIVAIGFYGSELQIGYGSAGGWDSFGPNRKITKSKANILYELDGKPALELYKTYLGEEADNLPSSALLFPLTIRDYNSADTGKVRTILAVNEADNSMTFAGDMPEGNIAQLMMANFENLVEGAEDSAKHAITDIIAKNGGEKLAILISCVGRKLVLGPKIDEEVEATKQMFDGQTTQIGFYSYGEISPQFGTGSCELHNQTMTITLIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT0</accession>
    <name>A0A654DVT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021474">
        <property type="entry name" value="DUF3127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11325">
        <property type="entry name" value="DUF3127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="13952" checksum="365BF9B67A1B3115" modified="2020-04-22" version="1">MTIDGKLIEKSPTQDVTDSFKKREFVVEYAENPQYPEFLKFELIQTNCQQLDGFEVGDEMTISFNLKGRKWNDPKGGTKYFNSLQAWRLDKKSGSGDTPPPPQTDEGWMKEDFSSDEDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW88</accession>
    <name>A0A654DW88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024883126" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="241"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="766"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="864"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1233" mass="129193" checksum="7E41C68BFF36749B" modified="2020-04-22" version="1">MKVIRKLGFLTLLFVIIGQNAYGQVDLSNGLTAYYKMEGDMTDASGNGYDGIYASGTNNYEISDRFGLFNTRRFSKGSDGSSVTPAYTSSDAALRSSSFTISFWYNIVDGFDDDSGVLDLGTMINAGTLYTISVVNEGLKFTTADGSGNTTSFTTNSGKPGIYQMATLTYDGTTLSAYLNGELKSEQSANQPALGSGAITVGYPFEGAIDDIRIYNRAISAEEVDALYSEVLFPDFSVDANSGTGSLDVAFSSSASTADASIANYAWSFGDGATSTSANPSHTYTQPGSYTVRLTVTDASNRSRALTKQSLISVASEVAADVQLQYVEYFFDTDPGVGNGTSISFTPSDSVEIIEQIDLSSLSAGFHQLMVRTRDGLGRWSCYINRTFYIMDLAEAPGATTGTVTAVEYFFDNDPGIGNGTSVDVTASDSLDLVATIDVSSLSAGFHQLMVRVKDHLGVWGIPFARTLYIMPQTSGANTSELIVSAEYFIGDDPGVGQATALELGANGASIEAQLEIGLGALVEGDYLLSIRVKDDLGKWSIAERRMFTISNGPISQDNTLSVEEDSILTFVADDFNYSSQNGSTFSRLQINLLPTYGELTLEGQLVSIDQEIAVADIELLEYFGGADFAGEDTFDFTVGDASTFGVSSSTMTIEVTSVNDAPVFSLSGDVNVDQDFTSTEVVTVTPGPVPANEVEQTVTYSIAPASVAFANVAIDAATGTVTITSVADGFGTQEFTVTADDGQAVHNTASSTFTLTVTPSNQTPQIADQTFTLDENSPAETVVGDVVATDPESDPMLFSILAGNDLGAFEIDESTGSISVLDGSVLDFETIPVFELEVSVSDGASEVTALITIELVDVNEVPVLSAGTFTVAENATVGTSLGLISAFDPENEALTWAITSGNSDDAFAIGSDGELTVNNAAALDFETRPEFLIGVEASDGSNSGSVDVTITVTDDGNQAPSLPDQTFTVDENSPVGAVVGTLAANDPEGDVLEYVITSGNAGDVFSMSIDGVITVAAADAIDYEINQEFALSVTISDGDLSTVGNVTISVVDVNEAPAIVAATFTVEEESASGTLVGVLEVSDPDSDALTISITDGNSSGAFTISNGVELTVADASQLDFEIQPAFILTLEVSDGTLTSSAVITVSLIDVEEPLTLGGVGHADLVVYPNPTKGILNIKGVGVERVKIFDASGRLVMTHTSAQVDLTDLKAGVYMIELLDQSGHVSMHRIILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW89</accession>
    <name>A0A654DW89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024849630" evidence="2">
        <location>
            <begin position="22"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="4">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="3">
        <location>
            <begin position="283"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="782" mass="87285" checksum="8B8149D8F89B5685" modified="2020-04-22" version="1">MKNILYLFLVVVAFSCNVPQSAPTQEAKASVLDYVDPNIGTAHSRWFFYTPAAVPFGMAKLGPSTDGSYGNEQGWEAVGYDSRHESIEGFANLHEFQVGGLLFTAMTGDLRTIPGTLDDPDGGYRSRFDKKDEEASPGYYRVLLKDYGVTAELTATKRVGYQKYTFPQSRDSYILLDIGNQLGESGKVKDAMVRYVGDGQVEGWVITYPEYVKKYQAGGEVRMYFSGVLDRNPDAIGTFRNEEAYEGEASISGKGAGIYFKYATEEDESIGIKAGFSFTSIENARENLDAEAADLTFEDALLAAQEVWAEELNKIKVSGSNEEDKTKFYTGLYHALLGRGLASDVDGSFPQNDGSIGSIPLKESGEPAFNFYNTDAVWGAYWNLTQLWALAWPEYYNDFVQTHLAVYKNSGWLGDGIANSKFVSGVGTNFVSLIIASAYQCGIRDYDVELAFEAAYKNEVAYQNRIEGAGKTDLEGFVKNGYVAYVPGWNTTSEGSGFSVSHSLEYAYSAYSVAQFAKALGKDDEYEELMALADKWKNFYDDEIDFVRPIMPSGEFIEDFDTFAPWIGFQEGNAWQYTFYVPHDPEALISRMGERKFVDRLDSIFTVSEKTKFGGEEIDAFAGLTYLYNQGNQPNLHIPWLFNYTDHPWLTQKWVRRICDEFYGTGPVHGYGYGQDEDQGQLGAWYVMAAMGLFDVKGLIETEPTFQFGSPIFDKIEIQTGASNELTIEASNNSKDNMYIQSINIDGSLFTESQIPYERLKNGAHIIIEMGSSPQKELYDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB5</accession>
    <name>A0A654DWB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="91" mass="10546" checksum="97E52B25E955EA63" modified="2020-04-22" version="1">MSNGLPNLKPPNHQPTDMVLYQEEKKYVDSLRKSLAEDNEISKEKIEELLNKFEDMMEMTSVSIKMIDRLMQNYDKLKQQNGAATVAVKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD6</accession>
    <name>A0A654DWD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022134">
        <property type="entry name" value="DUF3667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12412">
        <property type="entry name" value="DUF3667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="325" mass="37527" checksum="C2F33F8E6A47BEC7" modified="2020-04-22" version="1">MKKQKRKTENCLNCGFPLKSTFEYCPQCGQENTDNQISFGKLIKDFLANYFSLDSRFGRSIRPFFLKPGTLTREFMEGKRVKYANPIRLYLVVSLIHFFFFSINMDGKSDKNQGIIKQSTPDSTNNTPTIVTETEDLDSLDTSWPISGSEWKIINRMARDKAADYSIEQIEDSIHNEQKPFAAAYINRQIIKLTKSDMPTINRYIVKNIPILMFFLLPVYALLLKVFFRKGLYINHIIHSLHLHSFAFIALTFLWILGLISPSWADTMDIVFLLAIMGYLVISFKNTYQLGYMTAIYKVLLSGFLYTIIMGLSLFFGVVISLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI5</accession>
    <name>A0A654DWI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="107" mass="12536" checksum="9BF5A040D8550437" modified="2020-04-22" version="1">MELRRDVFQAIADPTRRAIIALVAMQAMTPSAIAENFKSSRQTISKHIQILTACEILEQEQTGRTIHYHLNPQKFKEIADFIEPFRQLWDDRFNKLEAVMKNYQSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS6</accession>
    <name>A0A654DWS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018707">
        <property type="entry name" value="LpxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037107">
        <property type="entry name" value="Put_OMP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09982">
        <property type="entry name" value="DUF2219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="36648" checksum="F76475C564645C68" modified="2020-04-22" version="1">MRKLFITIIALLLILKLTAQEKSQKKYLTFDYQLIVDNDAFTFDLTQDQYYSSGIYGSVRILKDSIANAKVIQSYQLNHRMYTPKWIGWDRQEQLDRPYAGLLSASIANEYYFHSNQYLKAQLELGWLGPGALVGETQATWHRWFGMPQPMGWKYQINNTPIINLNLTYIKPIYSSYNFELTSETNASGGTVYNNIRQELMVRVGELKPINKSAYVSSSLGNKRIKLPEPKISEIYFFYSPGLEYVFYNATLEGNFIGEKSIYTVDAIRWVFQHRGGVMLSWPRFDLGFIAYWRTQENASATRHDYVGVRLNQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT8</accession>
    <name>A0A654DWT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">MARINOS108_10847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="38"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="19104" checksum="05D221A169F4BD2A" modified="2020-04-22" version="1">MISEKLSKVIRDVPDFPKPGILFKDITPVLANPELSAEVSQTFFDYWSTKNVEGVVGIESRGFIYGLQLAQQLGVPFIPVRKAGKLPYQTIKHSYDLEYGSAEIEIHVDAITKGQRVLIHDDLLATGGTALAAAELIRKIGGEVIGYSFLVELSFLKGQERLKGSGEVHSLVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU1</accession>
    <name>A0A654DWU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="92" mass="9921" checksum="A63D8738FDBCF913" modified="2020-04-22" version="1">MNISELMAQGATVIDVRTPGEFQGGNVVGSINIPLNEIPQRVQEIKEIKGTVLLCCASGNRSGQAHTYLRHQGVDCENAGSWLDVNRLKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU6</accession>
    <name>A0A654DWU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18267" checksum="A693B4A7DE80DF62" modified="2020-04-22" version="1">MRQLMIVLIILSCLTGCKEENTDGIFVSMNVFLSLKNDSGADLLNPTTENSISADDISVYYLIDGDEVLFNEPQLDYPGGFAIEFDQSTGIYILDLFTSDHTNNESIATTIVKMEGMDSIRLDCEVKKYSNGSMQAVKVYYKNDLVWDNDRDKSSRYLEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ6</accession>
    <name>A0A654DWZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021448">
        <property type="entry name" value="DUF3098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11297">
        <property type="entry name" value="DUF3098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="75" mass="8290" checksum="95B57FF42B1F6CDB" modified="2020-04-22" version="1">MSDQHKFAFQKANYIIMLAGVLTLVIGFFIMASDSEPYGFGFLGLTLGPIVVMLGFLIEFVAIFYKGKKSESDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX01</accession>
    <name>A0A654DX01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside diphosphate kinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15666" checksum="7CB5CEBC5F2E9822" modified="2020-04-22" version="1">MNRRLITIIDYERLLALKELALLTTETSENVRKLYTELMHAHMLKPGYISENAITMNSRILLRELHTGRQIDLTITYPRDSNAMERRVSVFSEIGTALLGKLVGDRVSWKIKDREAHFEILEVLYQPEAVGHFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX04</accession>
    <name>A0A654DX04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="19845" checksum="C733F115241C399E" modified="2020-04-22" version="1">MKNLFVYLILILSGSIVHAQEIEWLSFEEAVAKSKEEPRKLLIDIYTDWCGWCKKMDRDAYANTHVAEYISKNFYAVKFNAEQTESIEFDGHTFKFIPQGKRGVHELAAALTNNKLSYPTTVFMDENLRIIQPIPGYMNAKSLDPILKYIGGDKFKNTKWEDFQKNYQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF2</accession>
    <name>A0A654DXF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="23488" checksum="7BF987917BB9F483" modified="2020-04-22" version="1">MSSKIFQYAGTLVFLISILFVAGLFTQTNPDHPSLNETSAEPDLYLSNVRHYAKEQLAERSLHHLDKAIESIKKIETDIDVNSKQKVDEAIVHLEMIYEEIVRDSLVSEDLNKAFEFALNALTLAELRISERYAESNNPVQAMVALKYAQMHLKSASQYSDLPNMNLERHIYYEIDSLILSEAMAPVLIAEKIDYFISEMDTLVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH3</accession>
    <name>A0A654DXH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GH15 family glucan-1,4-alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="221"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="593" mass="68411" checksum="568CA8A267491CC0" modified="2020-04-22" version="1">MQRHTYDYGVIGNCAYTAHIHTDTSIAWMCWPRFDSSFIFGSLLDKEKGGEFSVKPLEPDFKTKQYYVENTNILCTEVVSETGKYRVTDFAPRFYQNDRYYRPLMLVRKIERLEGNPRLVVKCAPKGNYGEITPQATMGSNHIQFLGLDAHVRLTTNISLNYVMSEESFVLNENKYLVFTYGAPLEGPLLETIENFLYKTKNYWRDWVKTANIVNFYQRAAIRSALILKIHQYEDTGAIIAAATTSLPESPGSTRNWDYRYCWMRDTYYTLNAFNNIGHFEESEKYFHYILNTTIEETNRYQPLYGISGQKALIEKELDLAGYMGNQPVRIGNDAYTHIQNDVYGQVLISLLPLYADKRIIFTERFDSSELVSKTLDMIEKTFDETDAGLWEFRNLRQHHCYTYLFHWTGSSAALKIAEVIGDKAMGEKAARLQKRSQEMIQKCYVPSKKGYAQAVGVERMDASTLQLIMMNYLDGNTQEAKDHLKALEKELHAKDGLFYRYKHQDDFGAPETTFLICAFWYVEALACVGRLDESIKYFENILSYSNHVGLLSEDVNEKDGGMWGNFPQAYSHVGLLNAASRIARKLDKPDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN7</accession>
    <name>A0A654DXN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4346" checksum="0BB059AF87E4FB9D" modified="2020-04-22" version="1">MYLSFPYLFDYLDVILSYVPRKIGLKNGSCGIPVGRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS3</accession>
    <name>A0A654DXS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt-zinc-cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="222"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="33022" checksum="B43B1689FAC9154A" modified="2020-04-22" version="1">MEHRVGTILGMDNEQTAIKTSYFSIIGNTSLAIIKALAGFFGNSYALIADAIESTTDIFSSLLVLFGLKYARRPADENHPYGHGRIEPLITFLVVAFLVTSATIIAYESILHIQTPHKVPQPWTLIVLGGIIAWKEVSYRIVIRKSELTNSSSLRADAWHHRSDAITSVTAFIGISIAIIFGKGYETADDWAALVASAFILYNSYLIFRPALGEIMDEHLYDDLQKEIRAVSLTVPGILSTEKCLIRKAGMQYHIDLHARVDGQISVTEGHDLAHLLKDTLCEKIPTLGHVSIHIEPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT6</accession>
    <name>A0A654DXT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase (DIM6/NTAB) family NADH-FMN oxidoreductase RutF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="32433" checksum="C14EBD3FE84F16AD" modified="2020-04-22" version="1">MAKIKPSDVSVPEFHQLLLGTIAPRPIAFASTVDKEGHVNLSPFSFFNVFSANPPILVFSPARRARDNSTKHTLENVLEVPEVTISIVNYSMVEQMSLASSEYDRGVDEFIKSGLTAMASDTVRPPRVGEAPAAYECKVIEVKPLGENGGAGNLVICEVQLAHISDDIFLNSKIDPFKLDAVSRMGGDWYCRAQGDALFEVVKPIKTKGMGVDNIPKSIRNSKVLTGNHLGKLGNVESIPSEQEVNDFANEPEVSAILQYVDHEPDRIQEELHKLAAQHLDAGDPLAAWKVLLQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY51</accession>
    <name>A0A654DY51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024866871" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="16842" checksum="45290628DF17C6DF" modified="2020-04-22" version="1">MKKLAVIALTILFIHTLSAQDITARTYIEKTVVASKLGTAIGYIFPCKVEVGGFYQKNADFMNGHEITKRFYEKEFAGMYLNLPLKHYRKINFDLNIRTGAVNGKNFVITPSLLGSYRPVKAIKMGVGLGTRMFRPTLQAALSIRLSKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA6</accession>
    <name>A0A654DYA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4619" checksum="C063568329C8B5C0" modified="2020-04-22" version="1">MHDQLGMRTDKDTYDLGYPVKQEYSFESGRMNKIRACSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH8</accession>
    <name>A0A654DYH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="451" mass="52480" checksum="57776D157587E9BB" modified="2020-04-22" version="1">MNELNDKPRTNKTMNKLKKFLMTMLLCMLSVSLFGQLKNKPELEEDFMDMGFGIFIHWSMDSQLGSVISHSMVGASEDYLQRYMNELPKTFYPDKFDPDEWARLFKLTGAEYVVFTTKHHNGFCMWDTQTTDFNIMNTPYGKDITGMLVQSLRKFGLKVGFYYSPEDFSFIHQQGHLISRKGPMTQVTENAELFEYSKKQVDELFTNYGKVDFAFFDSFSKKNLVQYVHEKYPEIVVTRGEMNTPEQKIPNEPMPGPWETCMTMGTQWAYKPTNEVYKDGGDLINKLIEIRAKGGNFLMNVGPKPNGEIPIEQEERLREMALWMFINDEAVKNVRTAPTQIKDGDLWFTKAKDENTAYVFITNQPEWFKGKRRLFYTESIRATEETEISVLGQNDMVVEYSPTNKPVSLFTQRSHNLEISVTRAQRVYNDKIWPNPIVVKLTNVEFVLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN9</accession>
    <name>A0A654DYN9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tsaE</name>
        <name evidence="5" type="ORF">MARINOS108_11494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="15980" checksum="F0E95646D6BDAD1F" modified="2020-04-22" version="1">MKTILISEEGELNAVADALLPLLTAQRIVCFNGEMGAGKTTLIKVICERLGVQDPMSSPTFSIVNEYRDMEDDPIYHFDFYRIEKLQEALDIGVDEYFYSGDICLIEWPEMIKELIPENHLEISIKLVGDNGREITIASHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP6</accession>
    <name>A0A654DYP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024852245" description="Beta-xylanase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="6">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="409" mass="46039" checksum="C52D46B1BF18C23C" modified="2020-04-22" version="1">MKMSKSILLLIGLVVMGQMAVSQEKPIADGMEKFLGNVYSSSQLSGYETYWNQVTPENAGKWGSVERTRDNYDWATLDAAYNFAKENDFVFRFHVLIWGNQQPSWIEDLPVEEQLEEITEWMDAVAERYPDVDYLEVVNEPINDPPSGAGNGNYIDALGGRGASGYDWIVTAFTMARERFPNAKLVINEYNIVSSSSNANKYKRIIELLQAENLIDVIGVQAHAFSTTGSSTTITDQLDKLGDTGLPIMVTEMDIDGSTDQIQLDEYKRVFPLFWEHESVIGVTLWGWRSGMWRTAQKAYLINTDGTERPALTWLREYASTPIDRTVLGWKNHSNLELFPNPVVDGQLTVRSKEPVHQVTLYDLSGHLVADFTPMEGQEVSLSLNLTSGIYLLKVQGTSKSELRKIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS4</accession>
    <name>A0A654DYS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="17713" checksum="7BAA5A28D1F1120D" modified="2020-04-22" version="1">MNEQSVFRIESRRFENYMQFFKIGAMISAIVVTMYLILKLAVFDGQVEYINLAGYAFAFSMYYEYKRKAKAWGGQFIEATGRVLSFKTRKNEQTTIRLDTITNIGIKLDQIILQTTELGEHTIVLEDFTEYKDRMMIKNKFAELKKQLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT2</accession>
    <name>A0A654DYT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17869" checksum="9F56698812FF1627" modified="2020-04-22" version="1">MQEAQGRKQLPSEPCKAENRQHYFNYPEPGIPYHLNLEVLNEQSRRLAENGGGWRKMAADLRAGVLAAVGLAGRVWCEGRALIHFPKTFFVSFFWSQKNESLPGKGGVLGRFKHRINTNIAIRYPEMLFGQLLLLRSILYFYGYILLPLTFAVMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU9</accession>
    <name>A0A654DYU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025039349" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="930"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108509" checksum="E9CC7EDCA9302D56" modified="2020-04-22" version="1">MNLKSLLSFSFLVLMTVFSWSGNAQSRSTTLYVDASYAGSSSDGSSDDPFKTIKEALDYRQSTLGLAGMVSDEEIIVRAGVYAPDSNGMIVLTQYNGGTGSYWLTLKTEGEVIIDGENLYNKKFAALITITSAAKNVRVQGFKLRDHRCNQSLATTETINGTPTLVKDTKFGIQVANSGENIEIIGNEIYDFSWTVNVDPMKDRLDFTAAEIDTLKSAAPNDNIGPISIVGTDSLPLLNVVVKNNLIHHVIPGWTEGIQLNGHLDGFEVSNNTIYEVQNIGIVAAGHYTWVPDIQGATVSSAQNYARNGVIKDNKVWSCRSPIAAAAGIYCDGSQNITVENNEVSDCQVGFSIGNENSGVHSGGHIVRNNLSFNNSWTGLVLGVPSAASGSYINNVSITGNTIYGNGGVTDTYLGSLGSSQLIIQKNIKNLTIKNNIIYATATNNLVTFAMAFDTTSYYSTISFDYNLYYTNSTADPAVGIFDWSQLGSGYDSYGTFAWYRVNRTDQDEHSSFQNPVFEDIVSSTPDFRLQSTSPAIDAGDPGYTVGTGETDIFGNERVFGDTVDIGAFESSSVAAGDIAATIDGVKSASEGYDALQTGVTTGVWRNIHAYDDNHFIYIYGEYEGTMAEYSIFVNTNSSTGYDYIWTEKSDYYVDGTLNLLNVYDTAASPSWPFTADNSVMTIRFVKTDSTIEGRIPKYALGIGSTGTVGLGIEGHSSGWSSSLGSIPVEDAAMVYLTLDGGSDAGSLAIDGYKSPVENYSALITGVTGSSFKNIYGYTDSDYIYLYAEIDTSALWEYNVYINTNGATGYQYLWTDKSDFYIDANYNQLNEYTGSGGWPFEESTNSAGIEFVMTPLAVEGKVLKSLIGVGSSGTIGIGLEGHTKNWGASLGGVPTSGSMVYLSLAGTGSRVAQETIVELLEESARAQLVMYPNPAVDQLTISHYLNEDGPVSVSVFGLDGRKYLYQEEFLLKGSHQQVLDVSGLPRGIALVRVESLSGVTTHKVLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY5</accession>
    <name>A0A654DYY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LAGLIDADG_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAGLIDADG_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="15372" checksum="E7BFE12AA2C0FDF9" modified="2020-04-22" version="1">MNWSYISGFFDADGSIQLNRIHRNQLPSPVMTFHNNERVILELIKAFIYDELNVNGTIVTKKKKGYADQFELRYSYFSKFKAIVGELVIHHPRKLKRIEFIQKYQGLSKRNGKYSNQELETIASLLKQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ07</accession>
    <name>A0A654DZ07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_110082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TOP_N" evidence="11">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="10">
        <location>
            <begin position="227"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD15920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="680" mass="77539" checksum="992D1C4AFD9FF183" modified="2020-04-22" version="1">MSNPFLSAYNTPFEVPPFHLIRNEHYMPALKQAITEAREEIQNIAESTDPATFENTIEALEKSGALMERVTSVLFNLNSAETNDELQGVAREASPLLSEFDNEVKQNTRLWERIKTVFENREHLSLDGEQSMLLDKTYKGFVRSGADLDGAKKERYKEISIELSRLSLQFGENLLAETNDFLYLVESKDDLAGLPKDVISRAASTAKQKGHEGKWAFTLQAPSYMPVMEYADNRSLREKLYRAYMCKALKGNERDNQEIVLQLSKLRAEKAQLLGYGTYAEYVLEERMAESPARVEDFLNDLMTRALPKAKEEVEELRAFMQELGADHELQRWDWAYYSEKLRKKKYDLDDELTKPYFKLENVISGVFQTAERLFDISFRRNEEIPVYHPDVQAYEVLDGKGTVVAIFFADFFPRDGKRGGAWMTSYRDQKKVGGEKVIPHVSIVCNFTPSSEDVPSLLKFDEVTTLFHEFGHALHGMLADTRYASLSGTHVYWDFVELPSQILENWCYEKECLDLFAKHFENGELIPAEYVKRLKKSATYHEAYATVRQLSFAALDMNWHNIPFEKAGTLADVRAVENEAFASTDLFPPVPNTNMSVQFGHIFAGGYAAGYYSYKWAEVLDADAFSVFQEKGVFDKATALSFKENILSRGGTEHPMTLYKKFRGKAPAPDALLKRAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ12</accession>
    <name>A0A654DZ12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydiI</name>
        <name evidence="2" type="ORF">MARINOS108_10821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="14927" checksum="A77AAA6751F6122E" modified="2020-04-22" version="1">MFPKGITPEGLNEFSINTLVSHIDIEFTEVGEDYLIAKMPVSEKTKQPMGLLHGGASVALAETLGSVAASLIVTPKGQFAVGLEINANHIKSAREGYVYGKATPLHVGRSTHLWEIRITNEAGDLVAISKITMAILDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ76</accession>
    <name>A0A654DZ76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin Q/BCP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17011" checksum="1769E11052E2797E" modified="2020-04-22" version="1">MNKGLKIGDDIPEVTLKDQEGHLIDLTSFKGKHSLVVYFYPKDDTPGCTLEACSFRDRYDEFEEAGAKVIGISGDSVGSHSRFASRHGLNFMLLSDINRVAEKEFGVPRNLLGLLPGRVTYVFNKEGKLVSTFSSAVKATRHIKESLKALSTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ86</accession>
    <name>A0A654DZ86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="27023" checksum="6B40710927D29DBA" modified="2020-04-22" version="1">MLYRIMGDLKDKLVVVTGGTKGIGRAIIEKFSEAGYTIATCARNETDLDDLKKSIEGKYGNKVLVNVSDVSRKAEVNDFIEFIRLTGKPVAVLVNNAGKFVPGQVHTEEEGVLESQIETNLYSAYRLSRGLIPEMKKRKKGHIFNICSTASITAYTNGGSYCISKFAMYGMSKVLREELKVDQIRVTSVMPGATFTASWEGVDLPEDRFMKPEDVAEMIFTTYQLSDRTVVEDLVIRPQLGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC3</accession>
    <name>A0A654DZC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="PTHR11374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="2">
        <location>
            <begin position="199"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="369" mass="40908" checksum="D2932D84835E23F8" modified="2020-04-22" version="1">MANNSIGLIGPGRLGLCVALLLEQKGYSVTAIEQNQRYLEALQTKSFDSPEPEVNELLRTSKHLRFSSDLKECLTEDHELIFIYVPTPENDQGYDHSILKGVLEAIMNQGERKHPVTLVVGCTTLPGFNQTIEERLKALNYHLVYSPAFIAQGTIVKNLQHPDMLLFGASDMTYALKTEVIMSQIALNHPQAHHMSLISAEITKLATNCFLTAKIAFANAIGDLASQSGADQKAILGAIGSDSRVGHKYLSYGYGFGGPCFPRDNRALNYFAREAGYTLQISEATERANEQHTDFQIAQLLQTTSQQEEIYFDHVTYKPGTDILQESQQLKIALALAKEGRLIKVCGSSKVVQTLKSTYGNVFRYEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC5</accession>
    <name>A0A654DZC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062045" evidence="1">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="360" mass="41604" checksum="2E5393A450FED135" modified="2020-04-22" version="1">MIKYFLTICLVLAGLLKSYAQSDSLTWEEKFALLEAEMDSMSIFYLLDSILASSPLKYSEFNARMSYNSNVLNAGRNYGVNQHSISPGMSYYHSTGLYADYAGFWNSQTTPEYNLSIFSFGYLGSFSKKWNYSLSYERWWYHQIESTGLNNNLGGNITYRNKLIYATIDYSLLFGEKYAHRLIGSLSGNVSLGKWWCVKSIKLLPSLSSTFGNSLITTRFEGNIIEEFRSNQILRTNFRSDEFQSYANTVLSDQEKEALRQIRESRNLTTREKITRQMKIYLTNDDVLNYLYALLDTTEEKYGIMNYNFSLPLMLVTEKFSFLISYTYSVPVQLPGEDYALDPVGYFGASVIYRIPFNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD4</accession>
    <name>A0A654DZD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein ApaG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">apaG</name>
        <name evidence="2" type="ORF">MARINOS108_10948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="SSF110069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="17120" checksum="21A1091D16CED070" modified="2020-04-22" version="1">MIDSKLKEKSYKFLSENKAMTTDTTKGIKVTVDTEYQQEYSNPVQRHYVFTYQITIENLSDKTIQLLSRHWDIIDLTFPKREVEGEGVVGKQPILEPGQMHQYVSGCNLKSGFGKMYGHYTMERLVDGKRFKVNIPEFEMVVPFKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI4</accession>
    <name>A0A654DZI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="19244" checksum="2E4A382EC0F05B8D" modified="2020-04-22" version="1">MVDMKYGELYLSKYIGFQHRLRKTFKIITFILSLSGILGWKYFQDYAWVILLIICVMQLLSLVGNQLVRSDKEVEEISALKMMYTKYFNKLERLWDELYTQRINDDEALERFYELRTTDWENIEQLDCKLDIKRFKRLMNKTEIETNDYINKYHNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM7</accession>
    <name>A0A654DZM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein OmpA-like peptidoglycan-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="542"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="658" mass="76053" checksum="F719D0F73137EA23" modified="2020-04-22" version="1">MRISLKKGVPLCLIATFLTLSCVHAQKEKKLYNKGLYAFYDEDFPAAAYFFQEISASGKSYKDSDYRLELSLLTQKEYRERPLDAIIKYSEIKQKTDKFYHYWMGRVFANRYMFPEAVESWQKFLKQKAYKSEEIVIETKDFIAQTERLIAFFDNPDNYEVHQLGKPINTEYAELSPVYFEEKNELLFASNRLDRDDFIIYQATSGDMGWNAPTEISVLGSFKREMTNIEVVNNDGKLFHFNAKKGDLFYSELTANGWTNPVEFDSKITSTKLGSHFYINEHEDRIIFASKNKKNGLDLMESFKDAESGKWEKPHPFATNLNSTANEDSPFLSEDETKFYFSSDRPNGVGGYDVYVSELDPETRQWSDPVNMGWPINSPDDEVNFKINPDLNSGYFSSNRIHSIGDYDIYFFWKIQKTTIEGRVIDGISQEPVTHGEIRFHPAQYLDEYFRSKLDSSGRYKTNIIANESFRVEVLQGFDTLMNQIFTVDGAEGDNVIHFKDFYLLPPELEAEQRAALEARFNQSPEENQDTEQTQEITSENTSDHQNTTLRNVYFEFGTSQLRKESDPKLNQLLTFLTDNPNIRIEVSGHTDNIGSKQANLIVSQRRAESVKTWLVEKGIDPSRIATTGYGESRPMASNDDEVDGRALNRRIEFRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ9</accession>
    <name>A0A654DZQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="152"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="34604" checksum="EBF96A19925DFDD2" modified="2020-04-22" version="1">MEAFKHHSYQVALVTLDLTEMDEHVIRYAAMISKILPIERIFFLHVAKTLEFPEELIQKYPTLMAPLDESIQAEIEQKVGQYFQGSEVKTECIVKDGAPIDKILKLAKVKSVDLIVMGRKKSLKGSGLVSSHIARKCPCSLLLVPENFRPEIKKVLIPVDFSRHSALAVHQAEVLTKKSPKDMALVHIYNVPTGYYKIGKTYEEFDEIIRGHARNECAKFQKDHQFSGDLECSFLSSKLDENEKLVHARAIEFGADIIAIGSRGRTTASSILIGSMAEKLVFHESDIPVLIVKNKGENMGFLEAILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E032</accession>
    <name>A0A654E032_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="552" mass="62678" checksum="1163F834F5FAA1C2" modified="2020-04-22" version="1">MSKVKKVVKYIVIFSIAMLLLANNIQLKSQVLGAIKYRDVEMEAGNVDVPHDRTLEWKKESAFADSIYKTIAAMPITEDMLVKKGDAAIILLARLLLRQDVSDVNAVIQRLPVWGNCGSSWSMNPKGDYDFTLTILTTILWKFGERPDVLYPETKKYLLEVLMIEDGGKFSYTVPRTLGMVMETENHMLMTEGSRYLKNRWVQLHGNTDRYYDNVRNGMEEKLLSLMEEMKTNGLYEFNSIPYLGYTITALLNIEAFASEKVSKTAREVLDYINWSYGLSSFNLKHFPPMRRRYEKASIQELTTDYHSAFVKSWLSYAAIDDYDDHVGVAMRHAFMGACMPYRPADRFVELLFDKEDGYFVRQGHGPEASPEISSAGRHFLLSAGGVNRGRKSQIVTRPICLFLNDTADHLSEVFHLSGPGDDFMHWNNTGVYENFACAAGPVSVPHEMQVIAEEGNWSAYSGPNDVSIIIYSTSEFGLVAVFQEVQTAAIFEEVIRENPDPEVLNTQFQFPDGPLLGYDTKAPHNQWVMQSLDGQKLNRDFDSWPLIEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E042</accession>
    <name>A0A654E042_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heparinase II/III-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024963422" evidence="1">
        <location>
            <begin position="22"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="932" mass="105935" checksum="D35F99639E08D86A" modified="2020-04-22" version="1">MNLKSSLIGVAVLLLASVLQAQGSESGAGENHPRIYVNKVQPTDFAKAVKKVEWKAEIIAKKQEQVDQYIEYCKADPKWLVSRLQMNWKTKHDKVYVRGGDFSYSEGEAPVPTVRFSGTRDWATDYMRPPLEEIEPYFDDDRGMYLRHKQTKEMEWVHPSEAGHIIEGINRHIMSIVEDAAFLYWYTGDEQYAAFALPVYDTYMKGMYYRDAPVDLDSTKQQWVSGLATFEVIHEQIVISLSLIHDFMYDYLGANGHDRNISVAVFQKWGDQIIKNGIPDNNWNFFQARFLTFIALTLDNNEYYENGKGQQYYLDHTFEVSTDRQIALKEAILNYDQQTGIWPESASYSMHVTETLLKILTVLDNATNANELENFPVVEKATLATFQYLFPNGEIVAFGDSRHQTLSAESFEYLIANYRKYGKTEKEKEITALYKSLLNTEKRGNGLFELFFYVDELVENGNSDTGELIASLTSPTFYAPNVSWFVQRMGSGDDATMVSTFGAFGNHAHANGIGLELYANNYVLAPDMGKGPSYWHEDHRQYYARYPAHNTVVVDGISDSRAMRVSQPFSLDNHFPESGDRNNIFDQVTFAKASFVEPATLSNQQRLTAIINGKSGKGYVLDVFRSERPDAERQKHDYFFHSLGQSLSFLDENNESLPLTSSEKLKEPGFLTAYDYFTDEKSMATSHDLNALFTLQGGEHPTSFLNVWMKGGENREYFAVKGPKSNALSKSSAPAALVDEKIPTLVIRSNKEAWNDPFVVVFNPFMEGKNQVISEVDFSENKNNKSSQVLQVTHEDKVTKDRIVVAASQNDIVEAEDFYQKGLLSITRETADELDFIFTAGATRYSSEGWEILSIREPVTLSIERTENGFEIQNNEAVLIGVPKRLNPAYIEIYVDGKLIATRKGMKSRNDPNRIDFRLEKAFQKVVIVVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D8</accession>
    <name>A0A654E0D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Gliding-associated ABC transporter substrate-binding component GldG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019863">
        <property type="entry name" value="Motility-assoc_ABC-rel_GldG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03521">
        <property type="entry name" value="GldG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="34"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="560" mass="62942" checksum="0CC7D41B127EA808" modified="2020-04-22" version="1">MRKSGYRLGLWLHLGIGVLIIVLLFQVADRYRFRLDMTEENRYSISDPTRNLLKRLDADVIVEVYLAGELPANFIRFQKSIRELLEEFAIYTDVNFDVKFVDPGEAASTRARNQYFQGLINQGLQPTNLNYTIDGKSTQKLIFPGAIISYGGRELALNLLKGNRASGPEEIINQSIEGLEYEFANALQQLAGTGRKRVGLITGHNEPDTSQLAGLNNLVLTKYDLFRVNLPTRTTPITGYDLLLVTKPTTAFSDREKYLLDQFVMKGGSVAFFLDALSVNMDSAAGDGTVAIPYDTRLADLLFKYGVRINQNYVADLNCGDFPVVAGNLGDQAQIRMLPWPYFPIITNYGKHPVVKNMDAVMVRFASTIDTVKAVGVEKIPLLMTSAHSKVMGAPVTVSFNDLQSDLMPEKFQSGPRTVGYLLEGTFTSLYKNRFPPQGFKKEEMVEDGVKNKVVVIADGDLVRNELSLEDGKPLPLGVEPYSQKTYANEAMLMNLIDYLVDEDGLVETRAKEVKIRPLDKVKVKQERTKWQVINLVIPIVLLLLFGVLKMIWRKRRNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G5</accession>
    <name>A0A654E0G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15871" checksum="A3172E1867B0AE8E" modified="2020-04-22" version="1">MESRIKGLLEKYWAGETSIQEETELKEHFRENPSLTSEGSYFRELNRLKADPEVKFTHPGRAGRKARWSVAAVVTIGLMAAVLVIQDARKQSEFAVEDPKEAFEITRKALLMVSSGLNEGKTYSTEINNLNKAEELIREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L7</accession>
    <name>A0A654E0L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="24172" checksum="101986AE1F84B783" modified="2020-04-22" version="1">MSDNSENLLIIFVKNLIPGAVKTRLAKDIGIDGALDVYKYLVEHTFEVTQDLDCAKAVFYSEYVEIEDTWDTEKYKLFVQKGPDLGDRMMNAFKHGFDKKFKKVVIIGSDCFELKGTHIEEAFDQLDKNDIVIGPATDGGYYLIGMNKLYPQLFHDKKYSHDKVMMDVLTEIGEMNASFHLLPELNDIDTFQDLKDSDIEFEFVDPDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E131</accession>
    <name>A0A654E131_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="123"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="49991" checksum="7B995F592003663D" modified="2020-04-22" version="1">MKHILVLGAGRSSTSLINYLLENAKENDWKVVIGEKDTSIARKKFKDADVIEFDINDKALATAQITNAQLVISMLPASLHPIVAGICAEIGRDMLTASYISPEIKALSDQFAASGNQCIMELGLDPGIDHMSAMRVLDRIKAAGHTLTSFETFTGGLLAEDKLKENPWAYKFTWNPRNVVLAGTGNVKFLQESRFKYIPYHKLFKRTEIIHIPGYGHFEGYANRDSLKYLDLYKLRGIQTLYRGTLRRPGFCKAWDIFVQLGATDDTYEMENVSEMTHRQFINSFLMFNPHDSVELKLAHYLNIGLESDEMYKLNWLNIFSEEPVGLDKGTPAQILEHILKKKWTLDDTDKDMIVMWHKFSYLDNGRPKEIQAHMIALGDDPVNTAMSKTVGLPLAIAAKMILQGKIKTTGVSIPTQQEIYEPILDELENMGFEFSERETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E165</accession>
    <name>A0A654E165_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GHKL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="387" mass="43609" checksum="2C08CA37DC81A920" modified="2020-04-22" version="1">MFTRFQERSRSFVDQAMKENSTEFQLRERVKELNCLYELSKIAWEEENDLKAIIAKSLVILPKAMQYPDLAEVSMTIHKKQYSTPHFSDCKWDISTPLTVGERKYGTIKIGYRESGDIASKASPFLQEERNLIRIVGRELSLFIRRASVEEDKQKLKAQLQHAERLAFVGELSAGIAHELNEPLGKILGFSQLLKKGGELNFQQEEDIERIIKASLYTREIIKKLMIFSRQMPQQIVPVNLNTIVSSTLYFIDVRFQSQGINIVERLDPNLPLIQADSVQMSQVLVNLITNAIHALPEGGQVTVSTRQKDNAVILAVKDTGTGMPPSVRKKIFEPFFTTKPVGQGTGLGLSVVQGIIDSHDGSIQVTSTRGKGSKFEIRLPIKHVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N6</accession>
    <name>A0A654E1N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="62" mass="7354" checksum="EA4AD244E15917CD" modified="2020-04-22" version="1">MDSFDFHSILFQSVGVYAMLIFSHEGFAAKFEEYPFIFHAGLYNCLLIKISQKYKDYHIKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q4</accession>
    <name>A0A654E1Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="293" mass="33550" checksum="37DFD48B50B7BDD5" modified="2020-04-22" version="1">MKYLLTSMQINHYTERYKKSLEWTVKIIVTGLCIYFISTRVDLSDISLKEAFDKPDGIIIYMIVLMLMPLNWVLEAEKWRVSIPHETSSFQEAWRRVLAGLALNWVIPFTLGDVGGRLLNVQNAKKSAGALLINRTILLLITLLYGGISVLYYFDWYNHWMLAIPFLVVGVGLLVLSSRGNGSMWIQVLALSLLRYVIFTFQFYLVLSLFLPELAWYLILLGIGWIFLFRSVIPSFFGNFGVREASAIVFFQAYVPDVSIVLIPCLIIWMINTVIPSILGTVYVFKLKLNIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q8</accession>
    <name>A0A654E1Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">YD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="86"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="354"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="500" mass="56049" checksum="B903083B051F5906" modified="2020-04-22" version="1">MKLFKIQILATALLIVSACSLEEEPYGFYSEENFLNTPGDAESAISYAYDALTFLEYSRTVFLVGDMPTEEAGPKQDASIDRHELNEWTVQNFSTNSSLVNFFKYAYIAINRSNYILDQLPAAQFDEDVKNSYLGEAYFLRAWNYFNLVRNFGRVPMHTSYVQTLDQTAAPIAGSIDEVYDLIISDCLKAIELLGVQQRLGRADKVAAQSLAAKAYIFIASAKEHGVPQYTDMSRDVSAMYDSAAYFSGEVLFNQSQYTFDDNLLDIYDVDQADGPEHIFIMSMDRSGTIEGDYSKISKLFIPYVAGGDIYMADGDGSYTVSHDGWSAFITNDAFYNSFQDDDIRGNLLMVDAVYDANGNEVASYPDNGLLYPFSRKYIDPEFIGDKTSTKPFLIRYTDIALTYAEAVGPTAEGYNQINTVRNRAGLGDLTPGLSVIDFREAIWQERAWELSFEGNRLYDLRRFKRVASVVPNAAGLSDEETTFYPLPQVETNLNKGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S3</accession>
    <name>A0A654E1S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="119" mass="13079" checksum="10BFD586616B20B3" modified="2020-04-22" version="1">MSKRVLIVDDSIYMRSLIRTALEEAGMEIVGEAKDGEGAIDIALEQQPDLITLDNILPDMMGFEILKVLRDEGLESKVIMISAVGQQTVVNKGKELGAADYIVKPFTSEELIAVVNRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U5</accession>
    <name>A0A654E1U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025020361" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="4">
        <location>
            <begin position="145"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="3">
        <location>
            <begin position="448"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121359" checksum="537A83863AFEE560" modified="2020-04-22" version="1">MPNKYKQLSVRLLKYSVRGMLVQCLFLASALVAEASTEENVNYTVAADLQQELTVTGKVTSEDGEGLPGVTIKIKSTGQGTTTNIDGTYRVKVPDEGAVLVFSFIGYKQQEITVGASSVIDVALEPDIQQLNEVIVVGYGTQEKVTITGSVASIKGEEMLQTRNENPQNMLTGRVAGVRVWQRSAEPGTFNNNFDIRGFEGSPLVVIDGVPRTMADFQRLNPNDIEDISVLKDASAAIYGVRAASGVVLVSTKKGSAGKTKISYNGSYTLQKPSRMPMLADPYETMTLYNEKSMNNISGGTIIYDEDDFEAFRTGRRRAADWNSLLLSDYSPQTQHNISITGGSDQTQYFIGGGYLFQEGFFKSGDLNYEKFNLRSNITTELTEGLKFNINLAGVLDQRNSPYSSSVDIIRNYWRQGVLFPAYADPENTLLNYQGLDLEQNTVAMMTSDISGYRQYNQRNFQSSASLEYDMETLASALKGLSAKAMISYDYRFDDNNSYRREYYQFMYDEATDSYASKLYNLSSPNQIRREMFNRQQVLGQFLLNYNRTFDSKHDVKALLGWESQRKKGDNFFARNDLAFAMDHLVGGTTDNMVSGMLGDPDNLYVIANAAALGRLNYSFADRYIAEFQFRYDGSSKFVEDNQWGFFPSGSIGWRISEEPFFNSVSALSFIDQLKFRASYGMTANDGSLNYEWYPGYIYPSTSGNAENGYYNQYAPGYVFGGEFVNGVDLIVANSHISWWKAKTFNVGVDFEGWNGLFGFSADYFDRRREGLFERRSGDVPTAVGTGAPLENVNSDRQFGIDLQLSHFNRIGQFSYKVKAISTITRRKWLTAVQNGPYANSYDQWRNDNLTDRYQGVQFGYEEAGRYEDWEDIWSYPIYKDRDILPGDYKYEDWNGDGEINSLDEHPFAFDQTPWMNFSLSFDGSYKNFDLSFLFQGTAMGSMQYQEPLYGIWGTNGGGTLTQYLDRWHPVDPSADPYDPETDWVSGYYGYTGNYPFGNSDFNRVSTAYLRLKSIEAGYTLKPKQSSSMNVRVFANTYNLFTITGVRFVDPEHPDSDLGRLYPLSKTYTLGISASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E250</accession>
    <name>A0A654E250_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated rhomboid family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_140151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="38"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23314" checksum="16A678592212B342" modified="2020-04-22" version="1">MISLTTLIIIVTVLVSLAAFNKAEVFQKSLMNPYLVFHKKEYWRLIASGFIHGSYIHLGFNMFTFYFFGRVVEQVFGQVLGGSSTIVFVLFYLSAIVVSDLPVAFKRKNDIHYNSLGASGAVSAMVFASILYYPLNDICLYGIFCLPGFILGIIYVVYSYYQGRNMSDNINHEAHLYGAIYGAIFGIVVNPHSAISFIDQIKTYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E288</accession>
    <name>A0A654E288_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribosome quality control (RQC) complex YloA/Tae2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="404"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="514" mass="59756" checksum="4816177BE3799DD0" modified="2020-04-22" version="1">MFHNYFFLKRLASDLHNLLVGYELQECFSQSKDELILGFAQEAQEVYIRANLNPQICLLQITSDFKRAKKNSIDLFARLRGKKVSSVRVYPFERSFAIDFENGYYLIFKMHASRSNVLLAQNHETLKLFRNNLPGDKELIPAELKKDPKLDFERFEALMGDPKAYIPALGKEVYQSLMELGYEQKNILEKWELMTHTLNLLEGNPIRIYQNNGTPVLSLLEQNLPILLETRETIAACTRFYEEYTRSYYLHSEKHAAVRPLEDTIKKTKSYLIKTREKLEAIKERRGYEEIANILMANLHQIPKGSSSVVLHDFYADTEITIKLNPEWTPQKNAENLYRKSKNQQLEINKLEENLRIRQAQLDTLEKKVAELGEAENIKTIRNLQPTQKKREKQEEVLPYHEYNFEGYHIMVGKHAKANDELTLKVANKDDLWLHAKDVAGSHVVIRHQAGKNIPKTVLERAAQLAAWFSKRKTDSLCPVIYTPKKHVRKRKGTAPGAMVVEKEQILMVEPKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A9</accession>
    <name>A0A654E2A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024930420" evidence="1">
        <location>
            <begin position="31"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="552" mass="61928" checksum="5F7B94B9663F153B" modified="2020-04-22" version="1">MNYILNPISKVFSLVTALVLLGCGSTTAPADVKSEGVLAESDFSISKDDLQNKIKGGWAGQTIGVVYGAPVEFKYNGSMIHDAQNIPWNEHYVKYWWDKKPGLFDDIYTDLNFVQAFETHGLDASADSIARHWSNTAYHLAHANQASRYNILNGIMPPASGHWKNNPHADDIDFQIEADFIGLMAPGMVNEATKIADRVGHVMNSGDGWYGGVFVSALYSLAFISDEPTYIVENAIKVIPEGTEFYECISDVIKWKKEFPNDWKQTWFEVQKKWNHDTGCPKGVFLGFNIEAKINSAYVAIGMLYGDGDFSKSIDIAARCGQDADCNPATVGGVLGVMLGYDRIPDFWLKPLQEIEMDDFENTTVSLNRAYGWSMKHALGMIEKAGGSIDGSEVKIPLAKPIPVAFEQNFENTYPIERNKIDESFTDEINFEFTGNGYLLYGNMAKRSKVDVAYIDRVSKRTYGSESFGLAEPDDPYVAIMEVYIDGELDQTVKLPMMNSARRLEPAWKYQLTEGKHTLKLKWVNHDPKYEYRINDLIVFSENEPSSNLPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B1</accession>
    <name>A0A654E2B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flotillin-like protein FloA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">floA</name>
        <name evidence="7" type="ORF">MARINOS108_20006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flotillin-like FloA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01562">
        <property type="entry name" value="FloA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="36202" checksum="428A46C9B2A10534" modified="2020-04-22" version="1">MITTVIILFAGIIAFFVFLYFVPINLWITAIFSGVRVGLLELVFMRIRKVPPSAVVNALITATKAGLTITEDESGLKRKLKTQDLETHYLAGGNVPQVIRALISADKANINLTFKQATAIDLAGRDVFEAVQISVNPKVINTPSVAAVAADGIQLVAKARVTIRANIQQLVGGAGEDTILARVGEGIVTSVGSAASHKEVLENPDKISKLVLARGLDAGTAFEILSIDIADVDVGANIGAKLQTDQASADLKVAEAKAEERRAMAVAEEQEMVAKAQEARAKVILAEAEIPKAIAEAFRSGNLGVMDYYKFQNIQADTDMRESIAGSGTKKSGSSTKKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G7</accession>
    <name>A0A654E2G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024904401" evidence="1">
        <location>
            <begin position="24"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="31571" checksum="FA14FE4F63D63A46" modified="2020-04-22" version="1">MIIQTKKILTMLILLLTVATLKAQQVTYQVLEDNPDKVYTKFIAPEFGMESNSTNLSFFAGANTRMGLTEAITLEGIARLDLYQISGSGPSFLLEAGGFLPLTSKIKKKEVPIVLSYNPYAGTVYKDGRSYNVEETKSIKIPEGQYRNELGGRGGLYMRKTGAESLAGNASSYILLTGAYLGGQWTSQAYVKTKINNDVERIGAGFTRVYADLLVLPVSTLDNPAANEGLKADGAIGWRLGFQWYVSPHDGDYKFLSNSVFTAELGKRPLTGFLFNMSWGFAFMNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H9</accession>
    <name>A0A654E2H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="205"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="472" mass="53676" checksum="05EC7C279CD9CAEF" modified="2020-04-22" version="1">MEKKYQLKIRQKNLLADMVTPVGLYLKIRDKYAKSFLLESSDYHGSENSFSYICCDPIASFKVENDQVEMSFPDGIVEHGSASEKREVLPFLRDFLGRFDIPNQDDKFIRTGLFGYMSYDAVQYFEDISLSNPKTPSSEIPQIHYSVFRYIIALDHFKNECYLMECHLDEPQDSGFEDLLNVISQKNIPSYSFEKSSETNSNFDDNTFLERVNKGIKHCDLGDVFQVVFSRQFSTRFKGDEFQVYRALRSINPSPYLFYFDYGGYKIFGSSPEAQIVVNKEEAVIYPIAGTFKRTGDDAADAELAKKLLEDPKENSEHIMLVDLARNDLSKSSDEVKVETYKEVQYYSHVIHLVSKVTGKLRKDADPLDIVASTFPAGTLSGAPKYRAMELIDENENIARGFYGGAIGFMDFNGNFNHAIMIRTFLSRGNQLYFQAGAGIVSKSDPQSEVQEVYNKLAALESAMKMAETINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V8</accession>
    <name>A0A654E2V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="24198" checksum="04D51A07F1533F01" modified="2020-04-22" version="1">MSSHHIVRDQQEPALILHRLDSFPVSHLHALLEWSPTVICCEPGIDKYTSLGHKLDFALVSLNRFESWKGRLDNQQPVKIIAIDDSHFLMTGLTVLQKEGHRAVNIITDEASVFDVIQLLTQWLNQLDLVVFTEKQKFLFVKNETFKKWLPAGTRLTLMALSEDSRWDVVGFQEDVKASHDQELEVVKAKEGEAEIHCSHPPYLVVEDLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X2</accession>
    <name>A0A654E2X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="17918" checksum="AAB5293B9A7E9765" modified="2020-04-22" version="1">MINKIIISGFFVLFLLVFACRPEPVRSQAGQWHLANLTNYTSYPEPGSPECLEYNGCQWAGYFAFVDGQQPEDWVKSHNIIAIHSKDAERYRLKTFLLRQGKLEIEATVYDMCADSDCNGCCTQNSSQTGFLIDIEKHTMERFGSGAGIVEWQCLDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y1</accession>
    <name>A0A654E2Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029483">
        <property type="entry name" value="GH97_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019563">
        <property type="entry name" value="GH97_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029486">
        <property type="entry name" value="GH97_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14509">
        <property type="entry name" value="GH97_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14508">
        <property type="entry name" value="GH97_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10566">
        <property type="entry name" value="Glyco_hydro_97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH97_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_97" evidence="2">
        <location>
            <begin position="299"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="GH97_C" evidence="4">
        <location>
            <begin position="587"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="690" mass="77826" checksum="A6B838A5CDC98A59" modified="2020-04-22" version="1">MKKFFGLSLISLMMVGCGGKSEKAWMVSSPDKQIEVKFFTQGGQPAYAVSYKGQSQIDTSFLGFMFQDQPALQGNLKVTSGITSSFSETWEMPWGEQREVENSYNELKLSLEETTPPNRKFDVVFRAFNDGVGFRYEFPKQPALDGETIILEELTEFNLTGDHQVWWIPGDWDIYEYLYNTTRFSEINAYSVFIPGDHLGQVYLHSNAVNTPVTMKSDAGVYLSFHEADLTNYPGMTLKVDTTNLSMVSELVGNKSGIKARVKAPFITPWRTVQIADRAGDLIESKMIVNLNDPNQVGDVSWFTPMKYVGIWWDMHLGRKTWDYASGNHGATTEYTKELMDFAAENGIGGVLVEGWNTGWETWTDPNMRDTIFDFTTPYPDYDLAELARYGKEKGVQIIMHHETSGAVARYEERMQPAYDLMNRLGIHSVKTGYVGTIIPDGEYHHGQWMVNHYQKTVETGAKYQVAINMHEPIKATGKRRTFPNEIAREGLRGQEYNAWAAEGANPPEHLPIVAFTRMLAGPIDYTPGIFNLTLKPYKEDHPIKSTLAQQLSLYVVIYSPIQMAADLIEYYQGNPAFQFIRDVAVDWEQSKVLDGEVGDFVVTARQAKGTDNWFVGGLTDENPKPYTLKLDFLEEGKTYTARVYRDAEETDYVTNPTAIDIVELEVKKGDEIPVNMVAAGGFAVSLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A1</accession>
    <name>A0A654E3A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5929" checksum="35984F2E32A57949" modified="2020-04-22" version="1">MFIENPTLETNMSKASVMDIILFTYFKDTKIKRLLFYRIMLLFYRIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D3</accession>
    <name>A0A654E3D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="22029" checksum="236AA81670AA2281" modified="2020-04-22" version="1">MFFSRKPKGPTKKYIAYKSKMAKYRNVMTAFKNQGDRRLVTYFFEQTGKEVRQLCEALELTISEPGSSSGADITLINAYDLGKHPLLDSSEIVCIEVHPLSRVNALVEEAFQHKAGGQITYYIGMDEPLFEVFGAERMLRLMEQMGMEENEPITHPMISKSLERGMEKLQKTLANPQDIRTSPEEWRTANMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D6</accession>
    <name>A0A654E3D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="60" mass="6704" checksum="083EB20046ECC9E9" modified="2020-04-22" version="1">MLDIPLIYRQEPEVLSTSFCSWEFFICMAQCESDTLNAPADKLLLSKLKKLGGHSAISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L6</accession>
    <name>A0A654E3L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="366"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="586" mass="66952" checksum="91AC33106143979A" modified="2020-04-22" version="1">MVTLLVFLMLLFADDQEPPTSLHRKALSFLEEDCEREASCVQVQELTVLFQNGDFDKAYEILIPEFDHCTGEKCFLLSVLKAKIFYEKSLIKQAINEYKVSLDLRDKLPPSYREDFAIEPVMASLLLEEEAFLTAIQYLRPWVERYSASENKDQFGDYYHNLGIAYLHLKKFDSSAFYFNRSIEIEMEMADTLGLAISYMDIANLYYEQYMDDQAIPYFQKGLEYALLAQEPDVLRNAYLNMAVVEENRGDLQRALSYRKDFEKVQNTLWNRDKVWEMAEKEKIYEIGLKEREITILEQKELVKNAELSRQRWQIKAYLIASVFLFILAGVVGVGYRIVSHSNKQITEQKRVLEQMDTAKNRLFSIVAHDLKAPVRSLQRSQQKMAAAASAQDKETLLALASVNGHLLNATQNLLNNLLQWSLDQTNQVHLMRESIEPGRLIEQVLYDYEPMFQEKGIDLETDFVSGSMVLVDIQSMKVVFRNLLDNALKFTPKGGRVHIATSTRGDMVRIAIEDTGCGMEQEVVDRLFEISQAKIQTGTDGTTGTGLGMILCQAFVSRNGGTIEVESQVGKGTIITLNLPRIAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R5</accession>
    <name>A0A654E3R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein CapI</fullName>
            <ecNumber evidence="2">4.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">capI</name>
        <name evidence="2" type="ORF">MARINOS108_20551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="359" mass="40754" checksum="1160501B7C9FE784" modified="2020-04-22" version="1">MLMITCKKGTMILALHKKNPLEKQTPILVTGTAGFIGFHLARRLLNEGYQVVGIDMVNDYYDLQLKEDRLKILEAFEGFTFYRFNLMDKPKVFECFEKHGFQYAVNLAAQAGVRHSLTHPQDYIDYNLTAFLNILEACKKFGIKHLVYASSSSVYGANTNLPFSEKHNIDHPVSLYAVTKKANELMAHAYSVNYNIPTTGLRFFSAYGTWGRPDMAMFIFATKMLKDEPIDVYNNGQMLRDFTYVDDILEGICRLLPQPSLPDPAWDSNDPNPSTSFGPYRIFNIGNNSPVKLMDFIEAIEKKIGKKAKINFLPLQTGDVPSSVSDVSALEEAVGYKPSTSIETGINNFMDWYREYYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T5</accession>
    <name>A0A654E3T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="16789" checksum="79564CB9B12A597A" modified="2020-04-22" version="1">MGKIFLNTEGEINPLHVGVPHEYSRESTVIFECPICKQTGQFPLVTGGLMEVGTIDLKFPNTSEYTLFELRKFANKFGLLEQTYPKTGIHSFQYETAYGRKEAFIKLYRCKTCNSELAFCFTTYGDFSRFPGQNIILIGVEIFQTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U0</accession>
    <name>A0A654E3U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">recA</name>
        <name evidence="11" type="ORF">MARINOS108_20939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="201"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD19851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="36884" checksum="06C9B9161C554740" modified="2020-04-22" version="1">MSDNTEKLKALQLTIDKLEKAYGKGTIMKLSDNKVLDVPTISTGSLGLDMALGVGGIPKGRVIEIYGPESSGKTTLAMHCIAEAQKKGGLAAIIDAEHAFDKTYAEKLGIDTENLLISQPDNGEQALEIAEHLIRSGAIDIIVIDSVAALVPRSELEGEMGDSKMGLQARLMSQALRKLTGAINKTGCACIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGQIKESADNVLGNRTRVKVVKNKVAPPFKVVEFDIMYGKGISKSGELIDIGVELDVIKKAGSWFSYNDNKLGQGRDAVKLLIEDNPELMEDIELKIKEKIQGSVIKEPADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E419</accession>
    <name>A0A654E419_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Alpha-1,2-fucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="PTHR11927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="33173" checksum="10B729766C23198F" modified="2020-04-22" version="1">MIIINSRGQLGNQLFQYAFGLATSRHLKTPFLITKIDLKDDLQYFVGPSRNLGYLLKRILHPRLYNFMLRCMWGGVLKKEVNVSNWDHPDSAKPLLERGAFFIGYFQSSLFFESHRNLIVNSFRVRPKYVMAFDKLYANKLRRRKLLVIHVRRGDYQHSGNEKLGYDLSLPVQYYEMARSYIDGIDQYYKVVVTNDVAYCEKNLTGWGAHEIVQNEAIIDFQLIQFADVAIISNSTFAWWAAYLNKKEDRQVIVPKYWLGFKVKREYPVAVIPEGWHQIEIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E478</accession>
    <name>A0A654E478_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF RNA polymerase sigma factor SigG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigG</name>
        <name evidence="4" type="ORF">MARINOS108_20394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="19142" checksum="64FEB3F99A3CC5B6" modified="2020-04-22" version="1">MSNDFYTSSILPYAAMIIKICRAYTNTQEDFEDYYQEVCLQIWKSRNNFRGQSEWSTWVYRLSLNVSMTLLKKQKNNRQHLDSGYLPSEVSDEPRAFTEDALEQLYSAIRQLSEVDRGVILLYLEEKSYQEIAEIIGTNPNNIGVRVKRIKERLKKLLDGKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E496</accession>
    <name>A0A654E496_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="119" mass="13555" checksum="C0B63C50C8DAF92F" modified="2020-04-22" version="1">MNTSDNHDEQSSAVKLASGSYDLIQKDLGIADELDFDPGEDPFGQLHAFLTPRIQHLLDHDFGYLINAMYRIDISEEVLKEILEHSKPGQIASDIAERVIAREKMKMKTRMMYSGNKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B8</accession>
    <name>A0A654E4B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021279">
        <property type="entry name" value="DUF2721"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11026">
        <property type="entry name" value="DUF2721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15315" checksum="28C7F2EA87E50781" modified="2020-04-22" version="1">MEVSLTTPALLFPAISLLLLAYTNRFLAIASIIRQLHTKYLNNPESVLKGQIQNLRLRLFLIRTMQFFGVGSLFLCVLAMFFIYLKVGEWGSVIFGISLVCLLLSLFISLREIQLSTRALEIELSDMELGTKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D3</accession>
    <name>A0A654E4D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">MARINOS108_20953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="68"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="406" mass="44517" checksum="BAD038D0D99AF8BE" modified="2020-04-22" version="1">MKYLVKKFDQHLHGTVQLTSSKSESNRALLINALSGNQLQLHNLSAARDTQTMERLLKESGEVWDVLDAGTTMRFCTAFLAIKGSGQTITGTPRMCQRPIGVLVGALRKLGATIEYLGEDGYPPLKISGIKDQQTSLIEIPGNISSQFISALLMIGPSLPDGLTLRLTTEVFSKPYIEMTLDLMRRFGVESLWEGNEIKIAPQAYSSGAYTIESDWSGASYWYSLAALGMNSELTLLGLRSESLQGDQEIATIMEKLGIKTTYDNKGATLTQTGEVAGEIEINFKTCPDLAQTVMVTAAAKGVTLKMTGLESLRIKETDRIAAMQNELRKLGASLIEEGSTWTMIPGTLPVTVETIDTYDDHRMAMAFAPYCAINDITIDDPSVVQKSYPDFWKDFQSVGVVIEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J9</accession>
    <name>A0A654E4J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdA</name>
        <name evidence="9" type="ORF">MARINOS108_20810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="41626" checksum="CC7B386DF8EDF646" modified="2020-04-22" version="1">MNFNLTEEQLAVRAAARDFAEKELLPGVIERDNAQQFPAEQIKMMGELGFMGMMVDPKYGGGGMDTVSYVLAMEEISKVDASASVVMSVNNSLVCWGLEHFGSEEQKQKYLPKLASGQQIGAFCLSEPEAGSDATSQRTTAEDKGDHYLLNGTKNWITNGNSASVYLVMAQTDPEKKHKGINCLIVERDYEGFVVGKKEDKLGIRGSDTHSLMFTDVKVPKENRIGEDGFGFTLAMKSLNGGRIGIASQALGIAAGSLERSIAYAKERKAFGKEIAQHQAIQFKIADMATKVEAARLLCLKAAMLKDRKEDYSQASAMAKLYASQVAMENAVEAVQIHGGYGFVKEYHVERFMRDAKITQIYEGTSEIQKIVISRNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R3</accession>
    <name>A0A654E4R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="5002" checksum="F0982DF8475232AD" modified="2020-04-22" version="1">MALSTFAWSYASYYIRAVLNHLSGVEGSFSAGKALYDYFRIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X6</accession>
    <name>A0A654E4X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IX secretion system PorP/SprF family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_130008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025024703" evidence="2">
        <location>
            <begin position="19"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="560"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="641" mass="72099" checksum="33425D7DF91046BC" modified="2020-04-22" version="1">MKKFLWVILLCFSQFATFSQLLPKVYNQFFMNPYIYNPAYAGVEGHTVLFVMHKEQWGGIDGAPSLSHANFHVPLKGGLAFGAMVYNERAGLYTQSAGKVTGGYLVSIDREHFIRFGLSLGAGNNSLNFGEFDSPTDPAFQGLLTNETFMVGDFGMAYHFGHFNVGVSLPSLFGYDLFTTESATPMHVRPHDNLLFKINYRGHLSDNIAIEPHLIYRYHSYLANQYEATVILHLLHIVWVGASYRQDAGFVGLLGAKFWERMGVGYSYEYGNPNTAALLGATHEIHIGYHLGSKKDHAEHVSSFIKSHRTSAEERAREAELERQKQLQALQKSRQPVQSSKDEDELGLLAGAKKEEPVKAANNWNYEKENEPVERINKFGEKERGIKFDRVNEQGEKEVVFSWLPPPPPGAKEETYEIANPDDEPLIRTRPDGKREAGIKWIRTIDGDRKETLIIWDEILSESAAEAIDHNPAEAHAMKDAKISIKAEVPVKEEPVVKEPEVEVVEEQPVVKQDPKVEPTPEEKVEIAKGDPELTDDFRPLDDYAKSDGHQVAKRGNHLLELPAGNYVVAGVFGSFQNAEDLSDILFERGFHDTKVGFLSARGYYYVVIFNSSNLQRVISEKNRVKNLSGLSKVWVLTVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E552</accession>
    <name>A0A654E552_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="3">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="3">HAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">nbaC</name>
        <name evidence="4" type="ORF">MARINOS108_60139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="PTHR15497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="20386" checksum="A9FA1731DA578AAA" modified="2020-04-22" version="1">MAIQRPFNLQEWIDNNRDLLKPPVGNKNLYADAGDYIVMIVGGPNARKDFHYNETEELFFQLEGDIIVKIQEDGQAVDIPIKAGEMFLLPAKVPHSPIRSEGSVGLVIERKRKPEHTDGLMWFCDACNHKLHDTYFHLTNIEKDFLPRFREFYNAEEKRTCPNCGSIMQTDQRFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F3</accession>
    <name>A0A654E5F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="22446" checksum="A733C175C4EDFC19" modified="2020-04-22" version="1">MKIISALFHPLLMATYCSVLFYLMVPEIYSPIPLQSVPYFIGAIFMTTSVVPAMSILFLKLTKKVSNLEITKLEERSLPFLSIGAFYGVTTYMFYTKMRLPITLLVIMIAVTAMIFAIFLISLRFKISVHSAAVWGVAGLFSAFSMKYLSTDLIMPLAGLFLIAGLTTTSRLYLNRHTPGESWTGAIFGFVFCFAALFFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5U0</accession>
    <name>A0A654E5U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate synthase</fullName>
            <ecNumber evidence="2">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aceB</name>
        <name evidence="7" type="ORF">MARINOS108_20108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="537" mass="61736" checksum="BCF6FC22FE33D484" modified="2020-04-22" version="1">MITEAHIPETQTPLGIQIKGATPAPYMEILTPEALEFLQALHVRFNERRKKLLRDRVIRQEAFDAGVMPNFLPETQDIRESDWTVAPIPEDIWDRRVEITGPVDRKMVINALNSGAKVFMADFEDSNAPYWSTNMEGQINLRDAIRREIEFVNPNGKTYQLNKETATLFVRPRGWHLEEKHLQIDEQPASGALVDFGLYFFHNVRELIKRGSGPYFYLPKLESHLEARLWNEVFVFAQNYLGIPQGTIKATVLIETLPAAFELHEILHELQHHSAGLNCGRWDYIFSYIKKFRNNRHKILPNRDQVNMTVPFMKAYSDLVIQTCHKRGAHAMGGMAAQIPIKDDPEANTAALEKVRLDKLREVMNGHDGTWVAHPGLVSVAKEVFDRHMPWPNQFHNLRRDVDVTAKDLVQTPTGTITEEGIRTNINVGILYVESWLRGVGAAALYHLMEDAATAEISRSQLWQWIHRHCYTVSGVAITVDLYEKLKREELVKIKAMLGEETYHSGRFEEAIEIFDRLVKNDTLEEFLTINAYTYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E659</accession>
    <name>A0A654E659_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proB</name>
        <name evidence="9" type="ORF">MARINOS108_90095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="29418" checksum="4A1191AFD06F5B21" modified="2020-04-22" version="1">MQHNPKNNLAFLNHRKEVKRIVIKVGTNVLTRHDGMLDKLIFRQVVVQLVKLIQEGWHPVLVSSGAVGAGRSIIGDSGITSEAIRRQVLSAVGQTSLMKRYFELFIEYDIVCAQVLTTKEDFAEGEHYENMMNCFEGLIGQGIVPIVNENDVVSLTELMFTDNDELAGLTASMIGAEKLIILSNVDGVYDDTGHVIGLVPFGDDAHKKHISVEKSGMGRGGMHSKVEIATRAAAGGIETFIANGKQDNVILDVLNGKAMGTRFAIKEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E679</accession>
    <name>A0A654E679_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_60040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="310"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="429"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="693"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="787" mass="89142" checksum="4269B49A52E027F7" modified="2020-04-22" version="1">MIRNFLKVALRSIQRNKVYSLLNILGLAIGLACAMLILLWVQDEMNYDSHHQNVKSIYQVMENQHYADRIGTTFSTPGPLGPYLKETYPEVKYSSRLTWESENLFTYQEQSFYEQGRFVDADFFHIFTFEFLEGNPQSPFTDKTSMVLTEKLAQKYFGNESAVGKVIKMNNETNFTVTGVVKSWPANTTNGDFDYLINFDYFWEDNLTWLDRWGNNNVRCFIQLQENIESSDFEGKIAHLLDEKNEDNAIVLFLHPLERVHLYSSWDNGVADGGRIRYVRIFTIVAFFILLIACINFMNLATAQAVKRAKEVGLRKVVGAYRGNLIAQFLSESVIFAFLGGVIALLLVLLLLPAFNTLTEKAIPFVLNPSALLLLATLVFVTGLLSGSYPAFYIASFQPASVLKGQMKSGKGASRFRKVLVTTQFVLSIIMIFCTIVVYQQLVFVQNQETGFDKQGLVYVEMHQNMRDKFQVIKQQLSQNPAIQSVAAMSQAPLGFNSSTWGFDWPGKDPQSKILFTNLSIDNTFTETFRIPLAAGRSFDPQFTTDTLHFMINEASAVAMGFKPEEVVDQPVTLWGDRKGKVIGVFKDFNFSSSKSKIRPLLMLHDPDWYNHIVVRANEGQNAAAIQALEEIYQEFAPAYPFEYQFVDDKWKEFYDNEARTASLFNTFALVAIFISCLGLFGLAAFTIQQRTKEIGVRKVLGASVLSIIQITTREFTILVLMAALIGSPVAWYLMDMWLEDFAFRIDVTFFIPLVATAIAISVAIVTVAYHAFMASHTNPVEALKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6E3</accession>
    <name>A0A654E6E3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="32537" checksum="01BA3AF1988F0F29" modified="2020-04-22" version="1">MRVLITGANGLLGQKLVSLLSGMHEITTIATGRGPNRNPAGSYSYLSADLTHPEEVNQLIRDSRPDVLIHCGAMTQVDECELHPDQCWQANVNATEYLLAAAKTVNAYFLYVSTDFVFDGENGPYEENDLPNPISHYGRSKLEAESLVLNSGLKASIVRTVLVYGVAHDPSRSNIVLWVKNSLEQHKPIQVVNDQWRTPTLAEDLAFGCWLVAKNRHQGIFHLSGEEMVSPYSLAIMVADCFQLDRSLISAVDASTFTQPGKRPPRTGFIIEKAKGMGFRPKSIAEGLAIVESQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6M1</accession>
    <name>A0A654E6M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4791" checksum="39536D790FD61F6C" modified="2020-04-22" version="1">MGWNPVKRGLIMRESLNWTLPNERNSGTLAGAFASWHLIHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E786</accession>
    <name>A0A654E786_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase BI</fullName>
            <ecNumber evidence="3">3.4.14.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapb</name>
        <name evidence="3" type="ORF">MARINOS108_90158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.14.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="35"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="506"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="723" mass="82786" checksum="668B41F3A1DD334E" modified="2020-04-22" version="1">MFTPQSSVLLLSAIFYLGCAGEPKNTTDKEELMQPPIAEKQPYELTGHGDVRVDNYYWMRLADEQKLASEPDEQTKKVLDYLGAENNYTREALKSTETLQETLYQEMVGRISQNDESVPYLSHGYYYYSRYEVGKEYPIYCRKKGDLSTKEQVILDVNQLAEGQEFYNVSGLKVSPDNKLLAFGEDTLSRRIYTIRILNLETGEFLKDEIPFAEAGVAWAADNQTLFYTAKNKVSLLSEEIKKHTLGTSTDTDKTVYKEEDPSYYIGCYQSKSGEYIIIWNSSTLSTDHHILKSDNPNGAFKQFTPREAVHEYSIEHFEDKFYVVTNWEATNFRLMEVGENDTDKSNWKEVLPHREDVLLSSIEVFKNFLVVEERKNGLNQLRVINQKSKEDYYIPMDEVAYKAGIDTNKDFETNTLRYYYSSLATPETVYDFDMVTKERQLRKQDEVVGGHDPSQYIVERIMVEARDGRSIPMSIIYKKGFKKDGSGPFLLYGYGSYGHTVDPGFSSSRLSLLDRGFAFGIAHIRGSQALGRSWYDDGKMFKKKNTFNDFVDCAQYVINADFTSSNRLFAMGGSAGGLLMGAVVNQAPELFRGVIAAVPFVDVLTTMSDPTIPLTTNEYDEWGNPDELESYEYMKSYSPYDNVKAQDYPNMLVMTGYFDSQVQYWEPAKWVAKLREFKTDDNLLLLNTNMEAGHGGASGRFRVYREIAMEYAFMLDLANIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7F2</accession>
    <name>A0A654E7F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Do/DeqQ family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="286"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="496" mass="52898" checksum="6DA05AFFDF7ED348" modified="2020-04-22" version="1">MSKRNIFFAMILSSFLGAAIALGGYATLVETEVTNQIQPVSGNNPVSFTNYVFDTTDYVVPQGLNFVYAAKSATPGVVHIRTKYAATTQSNGARNPMEDFFRDYFGDRYDRREGGPGMGAGSGVIISSDGYIATNNHVVDGASEIEILLNDNSTYKGEVVGVDPDTDLALIKVDAENLPTVKFGDSESMQIGEWVLAIGNPFDFRSTVTAGIVSAKARNINILARGGSATRIEAFIQTDAAVNPGNSGGALVNLKGELVGINTAIASPTGAFAGYSFAVPATLVKKVIYDLKDFGAVQRPLLGIQIVDVSSALAEQENLNVLKGVFVAKVNEGTSAAEAGLKEKDVIIAIEGKKVSNVAQLQEQVALNRPGDKIEVTFIRDGKTKTVDAILKNQFMTTEVVKANSAFQMEGATLEPVSDTYKEKFGIKSGVQVKSIEKGKWKEAGIEEGFIITKIDKRPIANMDDLSASLNGARGEGILIEGVYPNGEKAYYGIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9J4</accession>
    <name>A0A654E9J4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">O-succinylhomoserine sulfhydrylase</fullName>
            <shortName evidence="2">OSH sulfhydrylase</shortName>
            <shortName evidence="2">OSHS sulfhydrylase</shortName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">metZ</name>
        <name evidence="5" type="ORF">MARINOS108_60104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:27826"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family. MetZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071268">
        <property type="term" value="P:homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02056">
        <property type="entry name" value="MetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006234">
        <property type="entry name" value="O-succ-hSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="391" mass="42976" checksum="39EA7624D4E41B98" modified="2020-04-22" version="1">MSDKKFETAAIRHQIERSSQKEHSSPIYMTSSFKFDDAEDARSLFAEEKQGNIYSRYSNPNTDEFIQKLCLLEGAETGMAMASGMAAMFTSLAAFLSSGDHVVASRSLFGSTHQILTKLLPKWGISSTYVDILDDAGWEKAIQPNTKMIFLETPSNPALDLVDLEKICALGKSKGILVNVDNCFATPYLQNPIKWGADIVTHSATKFIDGQGRVIGGAIVTTEELFPEIKFMARHTGPSMSPFNGWLLSKSLETLAVRMDKHCDNALKLAQLLEGHSALKQVRYPFLPSFPQYELAKKQMRLGGGIVTFELKGGIDQGRKFLDALEMISLSANLGDTRTIATHPASTTHSKLSEEERLAVGITPGLVRVSVGLEHMDDIIADVEQALDRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB28</accession>
    <name>A0A654EB28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024953267" evidence="1">
        <location>
            <begin position="26"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="555" mass="63090" checksum="9E5ED83D32993CD2" modified="2020-04-22" version="1">MAQLFCMIRVLCFGMILLCAHLGAAQRVTVYLDGQPTTEVPGMDSVEVSRFVNLYLLRLWNQGFVFSGLDSVFSDRIYFHAGEKYRNEIDQLAVYDAEQDTFQLWKPKKQSFQSAVQKQLTTYADKGHPFVRITWDSVQVKDDMAKGFLRIIPGPLVVYDSMVLLGEVQKGRAFLQTALHLEVDKPFSERTFQNLPKSIARLQYLEMKRPPDVAFEHGKATVFLDLDKRKSSSFEGVVGLLPGQSAGNGVMVTGFLDLQLANLFQSGKRFLFTWNRFADESQSLDLGYYHPFFLSSKLFLDVDFHLLKQDTTFLTQSWNLTSGTNIGPMSEVFFGYEHVSGTLISPDESNISDNLADFTSSQYMIGLRDVLYGQEMGMKSPFRYQVRLVLGEKNISKNPSIDKGAYDTLHRQTSMLRVTAGAKYLIRLKKRTALHHHCEGQLLVNDQILTNELARIGGLKTLRGFNENFFYASNYALSRLEIRQYFEEYSHFMLFYDQLLMEHRGVVSYPRGFGAGLSLDTSNGLFTFALAMGMSRQIPADPANIKIHIGYTSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EER9</accession>
    <name>A0A654EER9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="35506" checksum="ABA2D02DB3B9D120" modified="2020-04-22" version="1">MLKAFNNWKVVLLSIIGATTFWFFNALNKDYDARISYPIEFQFDRDSVVIMQPLPTTLSIDVSSGGWNLLRKTFWFNVTPIQIVLENPTEIGFYTRNSLMPIVSDQLDELKINYLATDTIYINIERKRQKKVALFIDSLGIDLAENHRITSPISLAPDSVILVGPQSFYDTLGTSHQVWIESRGISSNFNREIDVKLKGGRLTSSIPDQVRIQFQVDKFERRSIQIPIEKENFPEDSSVVLSTDFVQIFYTIQQSKEEDYSTRDFAITADLHMLDRADSTVLAILVYQPEEAMDIDVIPENIKVIHVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF39</accession>
    <name>A0A654EF39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="505" mass="57371" checksum="1B410417874E712D" modified="2020-04-22" version="1">MNYTEIPANKLLSIKTLGALKNTGYEPLTIKEELRKNLIANFQKKHNVFEGIWGYEDTVIPDIERAILAKHNINFLGLRGQAKTRIARMMTLLLDEYIPCVAGSDLNDDPMRPISKFAKDAVAEHGDDTPIHWMHRSDRYTEKLATPDVTIADLIGDVDPIKAASLKLPYSDERVIHYGLIPRSHRCIFVINELPDLQARIQVALFNILQEGDIQIRGFKLRLPLDVQFVFTANPEDYTNRGSIVTPLKDRIDSQIITHYPKSIEIGKKITQQEANIEKSQSEQIGVFDLMKDLIEQVAFEARESEYVDAKSGVSARLTISAYENLISAAERRLLVNNEKKTFVRVSDLIGVIPAITGKVELVYEGEQEGPGIVAQNLVGKAIRKQFINYFPDPESNRKQKEGKNPYQKITDWFGDGNMVDVLHDYSAAAYEQELMQIPGLEQLVSDQHGKQPKEFKLFLMEFALHGLAEYSLLSKHKLERGMQFKDLLSSMFSMPEGEDEEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF83</accession>
    <name>A0A654EF83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="26191" checksum="35A5B2707F58A770" modified="2020-04-22" version="1">MEPEHRYRFISYSLFLASTFLILFVLDRFFGFHYAPDEHRLNQKPKVESSVKSHGETAEPAIKPETIPEDQPEFESPTGDAEKEAKETSEVQSSSKSNFFQTLKANYQAEVLSQLPPNKARTDIVIRYYQHAPDGNSAYALQKLGFYIHERPVDPELANYQSNAIYFGENVKLEDIQIVGLTLLSEGLPVKLIKPSRFGDSWKSNSIEIGTDTTLINQPTLTFSEIENLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSU0</accession>
    <name>A0A654DSU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="91" mass="10908" checksum="3E72053B925C2CF9" modified="2020-04-22" version="1">MEIKYTKHFLNRLEDIFSETDYMLRYEKGNFQSGYCILKDTRIAIVNKYYSLDGKINSLLEILKQIDINSKDLSEKNRKLFQEINQTQLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSY8</accession>
    <name>A0A654DSY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="20613" checksum="634717042499F74F" modified="2020-04-22" version="1">MANKKVSVAYVMATLIAVIFTWILHEFAHWLTSESFGHETIMRLNGTSPIDGKSVTDWQKTLISASGPLITLIQALTIFVVLKSDNWNKNLYPFLFTAFYMRLMAGIMNFINPNDEGRISAFLGIGTFTLPIIITGILFFLVYKISKKHHLGWKFQLATTLIVMTFSSILILSDQFFGIRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTB1</accession>
    <name>A0A654DTB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trxA</name>
        <name evidence="5" type="ORF">MARINOS108_10316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="10959" checksum="45DD8011656C89B3" modified="2020-04-22" version="1">MSNFHELINRNTPTLVDFYADWCGPCKLMPPILNEVKSNLGGAVNIIKVDVDKNNKAAHKYGIRSIPTLILFKNGKILWRKTGVAQVAEIQQAVRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTJ7</accession>
    <name>A0A654DTJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AAA domain-containing protein, AbiEii toxin, Type IV TA system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="533" mass="60387" checksum="DE1E9EA79BFB6DF8" modified="2020-04-22" version="1">MKIKNIKINKFKRFTDLSISDIPETARLIVLVGPNGSGKTSIFEAFNHFYQLGGYGDPGAQDYFEKKSETPVAGNWYQNRVKINFHGDQNPNGQQLKGKFYFRSAYRNEPDFTVNNLQKQNNPTDNIKLRTLMQNDQTVSENYQRLVAQTLAGVYEESNDTKSVQELREELIGKVKTSLSTIFDDLNLSSIGDPLSSGSFFFEKGSAKDFHYKNLSAGEKSVFDLILDMIIKSTFYSDAVFSIDEPEAHMHTRLQAKVLAELYTLTPTNSQLWISTHSIGMLKQAEIIEQANPGTVVFLDFANRDFDLTEVMKPAQIDRAIWDRFFDLAFADFSQLIAPRRIVFCEGTSQGRKYKDFDAQIYGKIFEGKYHDTKFVSIGSSTELENIENQSVKIVANILKSSTIIKFVDRDDKSPREAQENIDKGIRTSGRRHIESYLFDDELITKLCNSVGKPELTQDCLDAKNQAVLDSVSRGNPTDDIKSASGNIFTELKRILELTQCGNNKCAFVRDTMAPLVTEDTAVFRELENEIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTZ4</accession>
    <name>A0A654DTZ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">MARINOS108_10116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="4"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD10585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="414" mass="44124" checksum="7D86B2299FF1BB17" modified="2020-04-22" version="1">MKRVVITGMGALTPIGNSVKEFWENAISGQSGAGPITKFDTTHFKTKFACEVKNFAPETYLEKNEIKRSDLFTQYAIYAATEALQDSGLEIATMSPFDIGVIWGTGQGGMLTFEEEVGGYISNGRKPHFSPFFVPKLISNMASGMISLKFGLMGINYTTVSACATSNTAIMDAYNYIRLGKAKAIISGGSESPVTQSSIGGFNAMRAMSTNNDHPKEASRPFDEDREGFVMGEGAGALVLEEYEHAKARGAKIYAEMVGAAMTADAYHISATHPDGLGAAKAMELALEEAGHHAGDVDYLNTHATSTPVGDISEINAVRKIFGDAPGKLKISATKSMTGHLLGAAGAIEGILCIKAIQESVIPPTINTSKIDKQIPESIQIVTKEAIQQKVDLTMSNTFGFGGHNAIVIFKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU11</accession>
    <name>A0A654DU11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="14970" checksum="D5BA39512D4AADB4" modified="2020-04-22" version="1">MVDHKNITVLYVDDEKDNLFVFKANFNRKFEVITSISAMEALDELEEHHNQIIVVISDMRMPVMNGLEFIKIAKARYSKIFYCILTGYGYDDDIQQALSDNLILKCFTKPFDAREIEDTILLAAASRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU43</accession>
    <name>A0A654DU43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="23243" checksum="8529A710743D2286" modified="2020-04-22" version="1">MGGSNKKNGRQLLLQTGRTLFWKYGVRRISVEEVCKSAGVSKMTFYRSFENKEDLAFQVLKGFITEGMDSYRAVMKQDIPFREKIAKVIALKHQQSVDISQEFIQEIYQSTDSVLSAYIEESRKEMLSEIMYDLFMAQQNGWIRRDTKLEFILYMLNSLNDKMMDERFLSMYEDKHDAIMDLTNFFFYGIFPSEQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL1</accession>
    <name>A0A654DUL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024806688" evidence="3">
        <location>
            <begin position="19"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="240"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="705"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="953" mass="109058" checksum="45AB0672EB4D5B8F" modified="2020-04-22" version="1">MRTLLFFLFISLSFLVNAQSNNTLKVEQFTLKNGLKVYLNQDTTASNVFGGVLVRAGSIHESPDATGMSHYLEHMLFKGTQNLGTTDFESENVHYQKIINMYEQLETVTGGKRKKIQDQINAESIAAAKYGLPNEFSALMKSLGSTQVGAFADYDVTFYYSYFPARNMQHWIDINAERFINPVFRTFQSELEVVYEEKNRWDDDYENALYTTSQEILYPNYTYGLWPTIGKTEHLKNPSLTKMHEFFNRHYVADNMALFLVGNFDTAIAKQSIESSFSKLPSADYEPIEFPDYQPMSGERRKEISVTPFPMVSVLFPIKRIHHKDRPALDVVIYLLSNEQKTGILDQLEVDNKVQQLNIEIDEHALSSSLNIHAVPDPKSSLDETKSLILDEITKLKDLDYLNARLNGAKQNLIKDFWLELEDLEARALLIATCDFLNLSWEEALKYPNEIENITADNVLATIDQYFSKNYGLLISKKGQPKKDNLTKPSLKPIPTLQASSSDYGRNLLDKLSKEISEPLTIDFNLADTFSIGSNKGIAIRNAINDLFSLEIRLQTGWQTNPALQQTIDLLSRIATKQRSREELKSAFESLGCSFMASLERDEVIITLDGLEANLQACLKLVNELLVEPKVTSGSIESVYTSEKIKREEEKSSPFVLGYALIRYAVFDDQTRFRRRAPIETIKLTEPEVYEQRISELLQNTIRINYFGSKSKDELRTLLQKELQITPDQPPATSKKSSIREISQNKIFLINDSKIRQSQVYFYLKGDSIDRNQYPYIEAFNTYFGESLTGVVYQEIREYRSLAYSIFGRYIRPNGADEQGYLVAGFGCQSDKTDETIEVMIDLLKEFPHRDGRIETLRSIKMEEIVTNYPAPRQLGAKILAYQNMGYTNDPNEHAFHVYKDLKMTDLAKFYNSQFKDQPFVITIYGNKSDLDIQKLASIGQLVELELSDILTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS1</accession>
    <name>A0A654DUS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sanA</name>
        <name evidence="3" type="ORF">MARINOS108_10835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="24069" checksum="1C152499EF90D361" modified="2020-04-22" version="1">MQLLKKIAKYTVIMVGAVSVLVLGLNFWIISSTSGQIYYNITQVPSKKVALLLGTSKRTVKGGTNKYFKERIDATAELYHRGVIDHVIVSGDNNTVYYNEPKDMLNALMALGVSQADITLDFAGFRTLDSVVRSKLIFGQDELIIITQDFHCYRALFIADYYGMDAVAFSADNKDQLPLSLAIREILARTNTVLDLYVFNRGPKFLGEKEKLPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS3</accession>
    <name>A0A654DUS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="33201" checksum="8FEE498E8D50ACBD" modified="2020-04-22" version="1">MRLPLILLFIGSTLSGLSQVDERKFLLYERYLEFKFINQDDSLRSYTSYSYSLDPNKMTNGKDIDLFREDTISIDTFFLATGMVIMKNGRSQIIKDGLTFERTHSIENNLVKFFIDNDFPLKKRLIEWNTQQIRTGVYSPSSKGIFTKAMIVPHYKDFASLDSITYFLVPISPIKFKPSLWFKKRRYWEVEEFNLDEEWKCEVVWNRKKAGERQSSLERGVITYYIGTFSEDRKAKSIIYFTSGLIIFNKRVNTSLIFHRYPSICRRIEELNASSYVLNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV46</accession>
    <name>A0A654DV46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="18776" checksum="C737F57A6098D1C2" modified="2020-04-22" version="1">MGTYTWLRVEKYQLKRQIKRQLIAQTNKNDLILLKIAHKDSSLLSWEHSKEFEYQGEMYDVVERHQNGDTTYYRCWWDHEETRLNRQLQALVNKAFGKDPYHEANRERVETFTSGLICVPIPIFKFITSASTFQRQTLEMTPIYRQQKPPLPPPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV64</accession>
    <name>A0A654DV64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14352" checksum="B068F7659B31D295" modified="2020-04-22" version="1">MKSLILTGFLLFCASYLPVQGQSHKVRLAQLVIDSIHLEDYKALLKEEIEASLALEPGVLTLYAVSEKDRPNRFTILEIYASESAYQSHLKTEHFLKYKNKTVSMVQSLELIETIPLLPLMKIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA9</accession>
    <name>A0A654DVA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="29"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="39980" checksum="725621366FD67FAB" modified="2020-04-22" version="1">MFSHINFTAMAEYVEIIKDLQKGKYSPLYFLQGEEPFFIDNIIEHIELNALDDTQKSFNQYVLYGKEISFTDILNVARKYPMMGERQVVIIKEAQEIRDWKKEEAQKFLTAYLENPLATTILVFGHKYKTLDRRTKIAKTLEKHCVFLNSKKIYDDKVPGWVRSYAQASGANISEKAIMILTENIGNNLQRLANELDKLRLNIPADQQIDEVAVQKYVGISKDYNTFELQKALSLRDEIKVFKIITYFSANPSSNPLILVIANLYAYFSKLLLIHHQNAFDQNSVARAIGVNPFFASEYIQAARNYPAHVVVRNIELIHQADLQSKGIGSASMKDGDILKELIFKLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVG2</accession>
    <name>A0A654DVG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyisoprenoid-binding protein YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025065075" evidence="1">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="26"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="19622" checksum="F97664BD101BF85A" modified="2020-04-22" version="1">MKKANILTALVAVIALSAFTIKASIDWKISDEFSIKFTSEDPTGVFTKMDGDVSFDPDDLQSSRFDVKVDVSSINTGRGMQNKHAVSDKWFDADNYPTIDFTSKSFAKTATGYEVIGTLQIHGVAKEFTMPFTFEDDVFSSSFTINRLEYNIGDMKGMSKNVPEELTVDISVPVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV1</accession>
    <name>A0A654DVV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="807" mass="91444" checksum="7A2B5D4DBD1EB900" modified="2020-04-22" version="1">MTKTSLKAVFIFLTFTLLFGTIKTFGQENQTTETDEAYLSEVRGLVSFYQYMLNTVGSSKTPTRDKEAILTESYKKIFLNRQVQVEDDLLPDRNAITNKDVSGYLRDVDFFFKDISFSFEDIQITKAERENGKAYFLVEFQNTIEAVTLEGNPFKNTSRRFLEVNVNEEESDLKIVSVYTTKISREKELRNWWENLSYGWTRIFKAYVDFDTISDEALFKIAAIDSINLSGNQMIQDIRPLAALRALRVLDISNTKVDDLGPLRYAMKLEKLSASNTRLSNIDVLQYFENLKQLDLSQTLVQDIMAIGGLIRLETLNLSGSNVIVFTPLRSLTSLKMVDFSNTAFTDPEVLIGSTQLQKALLSRTGVKTLSVLSGFKALKVLDLSETYISSLVGLENHPALEQLSINQTTVNTLSPLRDCSKLKKVYADYTGVSESQASQLMSAKPGLVVVINSEKVIEWWKNLPFDWKTVLTQRVGLSNPSKEDVIKLLNIDSLDVSNQQLVSSKPLEKFTRLRCLNVSKNLFTDLRFTAGMSDLEFLVGEKLPIETLAGLEQNKNLKYVIVKGSLIQDIRSIQSLNKLILVDVDQSKITEDRVRAFLKVNPETVVVYQSEALLSWWEELSDPWRRAFGLSKTDAFTLHQLIESRSVKIENTPISSLRPLDRFINLKEVSLSNTGVTSLIDLNVHEGIEQITCKNGPLMDLEGLASLQYLRLLDISNTAVDDLRPISDNQTLMTLNCSGTNVKKLKGLEALRQLEVLNISNTRVWQLDRLYDISGLKSLICYNTRIRSHKIDEFKGVFPNCEVTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW2</accession>
    <name>A0A654DVW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="S1_2" evidence="2">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CvfB_WH" evidence="3">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="279" mass="31931" checksum="4F96E77D579F2C4F" modified="2020-04-22" version="1">MSLPLVEIGRINKLEVLKSTEQGLYLGDSVEEILLPNKYIPEGLEIGDYIDVFIYTDSEDRLIATTLTPHIMRGEFAYLKVKDATSFGTFMDWGLEKDLLVPFKEQLERMDVGKSYLVYMYLDNVTDRLVGSTHLNKFVEQNTIELEEGEEVQILVGNDTDLGFQCIVNGKYKGLVYKNQIFKDIQPGDTTSAFVKQIRPDNKIDLVLERTGHESIEPNAEKVFEVLKKNEGFLPLHDKSDPDEIKRLLQMSKKNFKKAIGTLYRQRLVTLDDKGITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX0</accession>
    <name>A0A654DVX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="54" mass="6413" checksum="82987B3DE74E8C38" modified="2020-04-22" version="1">MESTFSYEYTVPEEDDEGFHFEAGNIITIQYRVKNSLDNYGYRSLVIRLVDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW16</accession>
    <name>A0A654DW16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="418" mass="48558" checksum="D065868A1F9904B5" modified="2020-04-22" version="1">MRKLFLILILFVGFQAKCAYILIPMDETQTDHLKAYGITYWMLTQEVPADWLLNYRGGSFMVKHLQSIENECVIRNVSYEIISDAQANQILNEIASPASNMDVMKLEKYPKIAVYSPKSKQPWDDAVTLVLTYAEIPYDVIFDDEIMYNELPKYDWLHLHHEDFTGQYGKFYRTYQHFPWYQQQQREYEESARKHGYSKVSHLKLAVVKKIHGFVAGGGFLFAMCSATDTYDIALAAEGLDIVESMYDGDPADPNAQNKLDFDKTMAFQNFRLERNPYEYEYSDIDMQARERGLKQETDFFSLFEFSAKWDPIPTMLTQNHEHIIKGFMGQTTSFRKSLIKSDVVIMGETRSVGEARYIHGVMGKGFWTFYGGHDPEDYQHFVNEQPTDLNLHPNSPGYRLILNNILFPAAKKKKQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW85</accession>
    <name>A0A654DW85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain-containing sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="218"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="434" mass="49506" checksum="51927D5B8EEC23D1" modified="2020-04-22" version="1">MPISSEYLTSSNGLQLLNKIFLGAGEGIIIVDSEGKIRLINKRAEEIFEYEQNELMGRVIEDLIPKKYHKQHVPHRTEYIAHPVTRPMGIGRHLTGQRKSGSEFPVEVSLSYVMHEDEKLVVAFISDITRRKEQEDALRESEEKLKQYTAELESKVQERTQELEHLNLGLKSQIRERKLAEAALHSSLEELKKAEKEILNALEKEKELNEMKSRFISMASHEFRTPLTTIHSSANLVAKYTETEQQANRDKHVNRIKSAVNNLTNILNDFLSLEKLESGAITMKVEAFNMTGLFREVEEIFEQGLKKDQQLKITIEEGLTEVVSDPHILKNIIINLISNAIKYSDEGKTITATTSRVKDRIQISIKDEGIGIPLEEQKNLFQRFFRADNASNIQGTGLGLNIVKRYLNLIHGNITFTSKENQGSEFVISFPIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD0</accession>
    <name>A0A654DWD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025067235" evidence="1">
        <location>
            <begin position="21"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="549"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="614" mass="68801" checksum="6045C134D06D81AE" modified="2020-04-22" version="1">MRIYLYSILFILASAGQAQFAIKGIQNSHHRPLRTTAPEYPRTLPFWDDFSTSDGTPDTLLWITGGDVFVNATLGQNPPTYRVATFDGLKGNGLAHDIANGFNGPADSLISQPIDLSQVSNFKKTTVYLSFYWQAKGNGELPDEKDSIRVQFTTVDSLWVTQWVQVGGPENVSDYFQQVIIPVSGNEFFHERFQFKFQAFSSLKGPFDTWHIDYVYLNQDRHENDLSHFDRSLSGSPSPLFSPYYEVPADHFFRDPAKYLSVQSVLATNLDAETAVGHPLDYYYQLENLTTGEVYDLSSMGNGGLGGLDPLEYRNILGPSDIDIEAYNTPLDSQVIMSTFYYETGDKNLFEVVNGVDTVFLPVNLKVNDTIRTRYTLHNHYAYDDGTAEFSAAINLLKGQVAVKFALEAADTLTHVDIYFPNIAPDPSGSSVDILVWDRLDDARILSRQPYTIQSPTGLNQFTRIKLSQPVLTRDTVYVGYQQFTDNYLGVGFDRNNAIASNNIYTNVTGVWEQNTRLSGVLMIRPVFEFDSTFILSTPGTPLPAITAYPNPCKGTLSINGNFDQLTVFNLSGQTVYSSDKRSSYDLSFLEDGIYLLKINSNNSITTQKLIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWJ5</accession>
    <name>A0A654DWJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="374" mass="40629" checksum="4FF70BEB6BCF46B1" modified="2020-04-22" version="1">MAASRIIYLLLFSSLFSCKSQETEQEGTPVAKNVILLIGDGTGLSQISSAFYYKSTQPNYARFPFIGLIRTSSSREDITDSAAGATAFASGVKTYNRAIGVSDDTTEVATLVEIVSQQGIKTGLISTSAIQHATPASFYAHVKHRKQYEDIAAYMIDSDVDFFAGGGRQFFNQRSDGRNLLVDLEANGFRVDTTALGAFTDIKTQSRVAYLLAADHMEPVAKGRGDFLPKAAELGLQFLTKDGGNFFMMVEGSQIDFAGHQNNADYLISELIDFDDAIGKCLDFAEKDGNTLVIVTADHETGGFTLASTERENEDGSTYKDYTEINPTFSTKGHSATLIPVFAYGPGAESFAGIYENTEIFHKILKATQWSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK5</accession>
    <name>A0A654DWK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="12">FBP aldolase</shortName>
            <ecNumber evidence="5 12">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fbaA</name>
        <name evidence="13" type="ORF">MARINOS108_11313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 12"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="10">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="10">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="354" mass="39073" checksum="56A07A458794F5F2" modified="2020-04-22" version="1">MKFRPGVLTGKEATDLLNYANENGFALPAVNTIGTNTINAVLEAAREVNSPVIVQFSNGGAAFIAGKGLSNDNQAAAVAGAVAGAKHVHQMAEKYGVSVILHTDHAARKLLPWIDGMLDANEKHFAETGSPLFSSHMIDLSEEPLEENIGTCKKYFERMAKMDMILEIELGVTGGEEDGVDNTDIDNSRLYTQPEEVAYCYEQLMEISPNFTIAAAFGNVHGVYKPGNVKLTPKILKNSQDYIQEKFGTGKNPVNFVFHGGSGSTREEIREAISYGAIKMNLDTDLQWAFWDGIKNYYQAKEGYLQEQIGNPDGDDVPNKKHYDPRVWLREAEKSFISRLKVSFEDLNNINQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK8</accession>
    <name>A0A654DWK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="414" mass="48063" checksum="8D5BDD9711F306B3" modified="2020-04-22" version="1">MEELQDSPDITTRSEKKYSLLYVDDEATNLRVFKSNFRKFFKVFTTTNPFEAIDILSENEIQVVVTDQRMPEMTGTEFLEKILPDHPDVIKIILTGFTDIEAIKDGINRCGIYKYITKPWNFDEMKGLLDRAMETYQQSVDSEEHIKELEVSNVELERRVKERTEELNSINKRLIDSIRYAGLLQQSMLPNERYLSRIFSEHFVMYRTKYLFSEEFIWTTSLNFRSEDYTVIALIEFDGKGIVGSLKTLIADSILNDLIQDRKIFHSGDIIKELTQELDAAGSKELECDLKVSVALFDNNAKTLQFSGINQDMIIFNGKEMVVLEGESEENVDDLMADKIEIQEDATYYMFSNGYFNQENQDGVKFSQEKFEEMIKSIQKKTLSEQYKFLNQTIDDWIGEGGLTDDVSIMGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX22</accession>
    <name>A0A654DX22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="517" mass="60258" checksum="208D4FBE33435DBC" modified="2020-04-22" version="1">MQKYRILWADDEIDLLKPHILFLSNKGFEITPVNSGSDALEEIDHHTFDLVFLDENMPGMSGLETLNYIKSTHPNLPVVMITKSEEEHIMEEAIGAKIADYLIKPLNPNQILLSVKKILDNKRIVSEHTNQSYQQEFQKLSMTVQDLDDFEGWADLYRKLVYWDLEIDSTDDKSMLEVLNTQRSEANQRFSDFIVDNYRDWITDPDVDRPLLSHQVLKKKVFPLLKSEKPVFLIVIDNLRFDQWEILEPEISELFNIVNKDYYYSILPTTTAYARNALFAGQMPLDIAKNHPDLWVGEDDEDGKNLYEEQLLMKNLEKERLQVKASYHKIIKASDGKNLTDNVKNLMKNDFNAIVFNFVDMLSHARTDMQMIRELAPDESAYRSITKSWFSHSSLYDLLRYLSGKDVKVVITTDHGTIRVKKPYKIVGDRNTNTNLRYKAGRNLAFEEKGVLFTRDPDEFRLPKVNVSTAFAFAREDFFFAYPNNYNYYVNFYKDTFQHGGVSMEEMIIPLVELAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB8</accession>
    <name>A0A654DXB8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="25919" checksum="37E5CAB057FDE63A" modified="2020-04-22" version="1">MDYGLLFILLLVSALYASVGHGGASGYLAIMALYGFSPEVMKPTALVLNLFVAGVSFIHFYRNGYFKPGLFGWFVITSIPAAFIGGMIDLDPYIYRKVLGVLLIFAVLRMLGVFGKMQKEAQSPSRVLAMLVGLCIGFFSGIIGIGGGILLSPVILLLGWADVKQTAAISALFIWINSLAGLAGDYSNGLQISAQILPLIVVTICGGFLGSYLGSFRFNEVRLRQALSFVLALACLKLIWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG9</accession>
    <name>A0A654DXG9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ORF">MARINOS108_10261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="25780" checksum="FF0513CCFA67BD4F" modified="2020-04-22" version="1">MEIIPAIDIIDGQCVRLTKGDYDQVTRYSDDPAQVARDFELAGISRLHVVDLDGAKARHVVNIDTLRNITSATGLSVDFGGGVKTREDLELVLAAGAKQVTAGSIAVSDKEEVKKWIEEFGPDKIILGADVLDGKVMVSGWQESSGEELMDFLNYYVQLGIQYVICTDISKDGVLAGPSFELYEAIQLRFPALHLIASGGVSGKDDLIRLKRQGLYGAIVGKAFYEGRLTLEELTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI1</accession>
    <name>A0A654DXI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="242" mass="28119" checksum="D3B7A71E9CC726F7" modified="2020-04-22" version="1">MTKKSELSVSNHVSNERLSELKDQIDALRAELELIRQSTHAFETQLRAHLINELIEEQELTVLYKQQKLAKKEQRLAQKRRGKNYVAPEGLKPVVRNNKPGHNESDQKEMKRIYREAMMHVHPDKFSMDGQKMEVATDVTARLISIYQSGDLAALRAYHAHIFSDQELVSMMAPAAASVQPTAPAYDYLEQEKLNVEQELARAKSRQTYRVLTTYDDPMTFLEELKVYYDDRIAKLRRRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS6</accession>
    <name>A0A654DXS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="6914" checksum="3DA0372B4224F574" modified="2020-04-22" version="1">MGIDEQLRELEEKVNLGLKEAYRKMAEFKKKNNSPLVVSRDGKVISIPAEEILPTTNAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT1</accession>
    <name>A0A654DXT1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 6">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dfrA</name>
        <name evidence="9" type="ORF">MARINOS108_10371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="19185" checksum="AAAD64766EC6F827" modified="2020-04-22" version="1">MIISMIAAMGTNRAIGKDNDIPWHLPDDFQYFKQTTEGHHVIMGRKNFESLPPRFRPLPNRPNVVITRKDFFDAEGSQVVNSLEAALQIARENNEPEAFIIGGGQIYQMGLEVADKIYLTEIDGTFDGDTFFPEFDHQLWKETSRLHHPVDEKHKFAFDFVIYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU7</accession>
    <name>A0A654DXU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="16022" checksum="5D615EF2049409CD" modified="2020-04-22" version="1">MINRVVVDTNLWISFLITRKYSFLETLINSNKIKLLFSSELLTEFIEVAKRPKFKSYFNESDLDRILQFMKEFSELIEIQSDVHLCRDENDDFLINLCIDGNANYLLTGDHDLLSIGVINNTKIVSYGDFMEEMSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY4</accession>
    <name>A0A654DXY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024839405" evidence="1">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="22367" checksum="0AFE3C4AF352F241" modified="2020-04-22" version="1">MKNRKIIALLVLCLSAIVSKVDAQTKNPKHLQFSVEIDPATFAFKGYSLHLRMQPVGNDHLLLGVGTYAMDMPDVMVNLNEMNKEEGWEVRLNQGYSFFTEHHFSEVNRKWFIGGQAGIQQFKIKNDQVTGNSTFTNALLMGYFGYTLRPFSLPLYIKPWAGVGYTHQLSGSSRLEQEQYDVAPMTMFATLHVGYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ2</accession>
    <name>A0A654DXZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CelD_N" evidence="5">
        <location>
            <begin position="265"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="829" mass="92320" checksum="A70FEF12C48DFA6A" modified="2020-04-22" version="1">MKKNSNIKLHITIFLAFATLILSCDKKQNNHLKLNDQEYFQSRGLNVLVYTSWYNGLFSDEKKSGIELIHHEVRTATNGDVRLGPTPEQWDPIPTFRERKVDHENGTIEAFLHYPAFNFEYSVKVSQEGPSVNISVNLENPVPEELIGKAGFNLEFIPPAYFEKGYLMDEKSGTFPLYPSSSMEIKNGVVDPLPLATGSSLVLSPEDPKTRVAITSRMGDLALYDGRDKAQNGWFVVRSLLPAAKTGKVLEWTLEANTIPGWTRSPVIGHSQQGYHPDQPKKAVVELDRNDQSTSSAKLIKIAGDGSEEIVIGKALTQWGAYLRYNYGTFDFTEIKENGLYVIEAGNTRTEAFKISADVYGTAWQPTLDIFFPVQMDHMFVNEAYRVWHGKSHMDDALQAPVDWVHFDLYAQGPTTDTPYQPSEHIPGLDIGGWYDAGDFDIRTQTQCYVVQNLVNTWEAFGLDRDQTSIDQTLQYVDIHKPDGKADLLQQIEHGTLALIAQHRAVGHAIHGIVAAHLSQYTHLGDGVTKTDNLIYTPQLDSFKTDGFRSGTFDDRWAFTSRTTPLNYRSIAALAAASRALKGYNDALADECLTTAISVWKEEHAKEPDLFHHGNTTGGALDDEELKAATQLLLTTRDPQYAKRISELWPTIDRNFGQHASRIAAVLHLLDDDLKNKIPQRVAQYKIWMDSIETQNPYGVPVTTGGWAGSGAVVGFGITAYDLHQAFPDIIGSEYVFKSLNYLYGNHPGSDISLVSGVGTKSKKVAYGNNRADYSFIAGGVVPGVLILPPDFPENKEDWPFLWGENEYVVSVASAYLYLANAADHLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ8</accession>
    <name>A0A654DXZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01467">
        <property type="entry name" value="vWA_BatA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033881">
        <property type="entry name" value="vWA_BatA_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="107"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="39659" checksum="709A57F6893611CC" modified="2020-04-22" version="1">MESTNSWFSVNWFTWSKLQSFDWEQPLWFYLLLGILLLLLIRAVVMTQFRQRLPIALTKKDIKSDPVSYFRIIPPILFFITISLLVTALARPQSTNEQVEQWSEGIDIMMTIDISESMQIEDFRPNRLEAAKEVARNFVAGRFQDRIGLVVFSGDAFSRSPLTSDYDLLNSYIDDISFDLIENRGTAIGSALAVATNRLRESDSKSKVLILLSDGDNTAGNIDPITAAKLAQAYDIKIYTIAIGKEGKVPFGTDFFGRPRYVENTLDETNLREIAKIGRGNFYRVSDKEALQQVFSEIDSLEKAEIKETRYKDTTDYYTIYLRWAMIFFLLWLLTKSTFITNALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY28</accession>
    <name>A0A654DY28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024851407" evidence="5">
        <location>
            <begin position="29"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="123"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="383"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="995" mass="108891" checksum="22476310B880B345" modified="2020-04-22" version="1">MRMIFTLNKYYKTLLSVVLMSVTSWAIAQERTVNGTVTSAEDGTGLPGVSVLIDGTQSGTITDIEGNYSLTVPNDNSSLIFSFIGFEQQKINVAGRSTVSVELAVDLMSLDEVVVVGYGAVRKSDLTGSVSSVKAAEINAFPALSAVQTLQGRAAGVQISSNNGGQPGTNYSIRVRGVSSINSSSEPIRVVDGFVGAEMPPPQDIESIEILKDASATAIYGSRGSNGVILITTKKGSSGQIKVDFNSSYSFQNTTNKLELLDGPEFASYIQNFSPNYEYLGSNTDWQDEIYRQGMIANNQLSVSGGTDNVRYYLSGTYFDQDGVVIGSEYNRYSLNANMDVKANEYLKFGLNLYGRRSKDMGIRTQEGSGGSGQAGVVGAAMRFNPDLGIYNEDGSYTVAQVGDQIDNPYAMATEYDRERITDRFQSNTFAELDITEWLSFKTTLGIGVTNWRDGEFWPTTLIRGAGSDGLASISAQKQTSLLSENYFTIHKDFGQHRILWVNGYSYQKNSTESWGASSSGFINNAGRFWALNQGSTPSTPSSGYSQSSIKSFYTRLNYTIMDRYTFTFTGRRDGASNFAANKKWGFFPSAAFAWDVKGESFLKSVDVIDQLKMRVSYGSVGNQAIGPYQSLATLSVRNPHIAGTNALGVGSLANNVLSWETTDQFDVGADIGLVKGRVNLTVDYYNKQTKDLLFNRPLPSYIGVGSQWQNIGVLENKGFEFSVNTKNLVGKIQWESNFNISANRNKIVELADSVQIYGASPGHMLLGSSQLLLEGESIGVFYGYEYQGIYQNGDTFLPGSGFEQEAGGEKFADVSEDGELSNDDRKIIGNPHPDFIWAFGNTVSYKNFDLNVFFQGSHGNDMLSYTQMELETLSGKANASKIALRAWTPENPNTDIPKASSGRTYKVSSRWVYDASYVRLKNIALGYTFPTALLNGLHIRSLRIYASAQNLLTITDYPGLDPEVNYQNSSRNIGLDYASYPNVRTYTFGINLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL9</accession>
    <name>A0A654DYL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024853102" evidence="2">
        <location>
            <begin position="34"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="35605" checksum="289619EDE908F863" modified="2020-04-22" version="1">MLLLSISSRLQLFKMKTIKITILLLICWSTALAQNTFPTPSGNVGIGISTPLSKLHLYHDDSEVSANVGLTIEQDGTGDSKLQFLLTGVQRWVAGIDNSDGDKFIIGRGLDWSQSKNFVIDNSGHVGIGTLTPSKEFEVNGTILSNNFMSSASNTTYNHFIRNGTGAALYINQVESNASLPILRLSSGTATANQNVRFTVENDGSVGIGTTNLEGYRLAVNGSIRSKEVKVEANWSDFVFSDNYQLRTLEEVEQHINENGHLPEIPSEAEVTENGINLGEMNAKLLMKIEELTLYLIEQNNQNQAQQARIERLEEKISRLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM9</accession>
    <name>A0A654DYM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="12402" checksum="BC3D5BE394D2BB4B" modified="2020-04-22" version="1">MNGSFSQWQLYVPSENRLYSMLAVSNTPRWRTRVACALSSLEQYLFYSCDFLFFEYFSVVSRKYKFHNPEGLYFVSFATVYWLDPQWNWFLLETSIVRLCRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ63</accession>
    <name>A0A654DZ63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane starch-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="286"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="613" mass="68331" checksum="318AF824A82E2DAA" modified="2020-04-22" version="1">MKLINKQYIVALVLVTLFSTGCEDFLDENSVSYQTTDNYYVTAQGFEDLVRSNYTKLREIHKERDLVMMGTDLFTSLAWDEAGSGNQGSVLNTYDTRFTPNVGATTNLWDLLYSQISRTNTAISRQHDVQGIDADVLAIRVGEAKFLRAFAYFYAVQQWGDIPMPLVETTTASREVTKVPADQVYDQIIKDLEEAEAVLPTKGNTEYGRATKGAAQFLLARVHLTRGWNYNNSLGGTAADFDKAVDYADMIIAEYPLEPEYHKLFPLHAENPLEETFPAQNDKNAEIVFAVQYSDNIQTNGSDNDEPSEYQIGNDYHSLFGGDAESIPGSPGRTGDYNRHGGRNTYITTPATYRLFDPTLDTRYHHNFVEAMYALSDVNDFVPDLNNPGTTINIATGDTVVYFPPWNNPASASDKGMDVGGSKRYAVLNLDEIGINPVTPYHIKDMTPLMWKFWQPGLPYDEAQGTFDLALFRSAEAYLIAAEAILKGASNGNLGGAEVYYNAIVDRALGANAGSDPLCASQPANLSSMATVSYRANGNLDIDMILDERARELMGEYCRWYDLKRTEKLVERTSSMNPWTVALGQMKSTHYLRPIPQKEIDRTIPSISQNDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH0</accession>
    <name>A0A654DZH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General secretion pathway protein GspF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_12121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="43"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="244"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD14791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="378" mass="43648" checksum="8A9CB9EF3189CC1D" modified="2020-04-22" version="1">MKLTDLDISGPKVTQEKKQESFLTKEIDLFPHRVSDKEKETIYRQLNVLQQSGVDIRASFEILFQQLKRKKTREKLQMVLAEIVKGKSLSESLAQFKDFTPYEVFSLKIGEETGRLTLVFEKLTTYFENQIAQRRQIVSALSYPILITLTSFGAVSFMIFFIIPMFEEVFLRFNSDLPALTKTIIGLSRGFRSNALLLFSSVGIVLFSIYALRKNLRFRWFKEWIWLRVPLWGEIYRQIYLARFCDSMGLLILSAVPMVHTLEMVRKMIGFLHIEVVLDQIKTDLVQGKTITEAFEKHAVFDNQMIALIKVGEEVNQLGSFFQKLSLDYTNSVKHKTALMATFLEPFMIIFLGLVVGVILVAMYLPMFELSSSMDFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH7</accession>
    <name>A0A654DZH7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024975583" description="Beta-galactosidase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42" evidence="6">
        <location>
            <begin position="59"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="7">
        <location>
            <begin position="461"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="742" mass="84795" checksum="53BEF36EB118B389" modified="2020-04-22" version="1">MNMNYKSAKQKASILMLLVCLLLCYQNTMAQVQMPETIVYGTVYNIFHDEYATDKDFFKAVDQDMTNIKKANFNLVMPFPFGQWDAKTKTQSWKRTDYLVDQLEENQLNLMPIMLKSTHRAYLPTWKWVEMDDAIREFPEVGRSSEEVKYMHPEVMHSIEDYFESIANRYGNRKSLVGYNLWNEAHYNSIDEITIPKFRQWLQSKYGDLQTLNRVWAEDYGDWNQITPLMSRNWESSMAAIDWDLFRYANNGDIAKWARSTIRKYDKKHFVTINTVGTVENNTDYSQWTVDGRQISPYTDIWGISFYPDKYMNRTQEPMPYWKYSCMYDVTRADAGDKPYFLVEAQTNQQNGMGLFQFMSYDDIHLMSWIALADNCKGIVFWKWDPFYRGQQAFGRGLTLANGELAPRGEAAKDVGAVLKEHGKMLYEASLNQSEAGILYDIVALQKSQEAVGRPGSAGKMNYFMQESFEGTYKALFDANIQVDIIRTDMPLSWETLKKYKVLYAPYQLVIRKEVSELLKRFVKEGGVLVADAHSFVMDEFDFGFPINPGYGLDTLFGGRRLDIYSASTAFSISGSIAGDQHEYEGLYYQELLEPIANGEVVASFDDVQAPALIKNRSNKGSAYLSATSLGGSYYNGHDGAGKVLVSIAREAGVKSVATVNGQNKTHLMIREHTHKEGRLLYVMNLSNETFEGDLEISNSGNRAKSIKELISGEEVVFKSKGDGISINTSISPRRTTLFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR2</accession>
    <name>A0A654DZR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22981" checksum="C9B12DB3AE96C879" modified="2020-04-22" version="1">MAEFWEESFKDKREMWGLEPAKSSILTNDLFVEQGVKSVLIPGIGYGRNAKIFMQNGMSVTGIEISQTAIDMAKSHFGNDLIIFHGSVTDMPFDDHLYDGIFCYALIHLLDQHERLKLIRDCYDQLSDHGVMVFTVITREAQTYGQGTRIGKDRFEMFGGVKMFFYNEETVEEEFGASGLFEISEVNENYPFYMIKCRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E044</accession>
    <name>A0A654E044_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ORF">MARINOS108_120326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD16640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15344" checksum="012502BE9BA24BEE" modified="2020-04-22" version="1">MKIIIINGPNLNLLGKREPDIYGSQKFEDYFADLQSAHKDITLEYFQSNHEGALIDKLHEVGFDYDGIIVNLGGYTHTSVALADAIAAIKSPVVEVHISNIHAREAFRTHTQTGTNAKGIITGLGLKGYDLAIKYFVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E047</accession>
    <name>A0A654E047_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="8">
        <location>
            <begin position="354"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="677" mass="73419" checksum="433B5C4C552E7343" modified="2020-04-22" version="1">MSNHQKDQRAVDNIRVLSGAMVEKAKSGHPGGAMGGADYIHILYSEFLKFDPDDTRWPFRDRFFLDPGHMSPMLYSQLYLLGNYAKEDIANFRQWGSVTPGHPEVDVARGVENTSGPLGQGHAMGAGAALAAKFLGAKFGGWMNHKVYAFISDGGIQEEISQGVGRIAGYLKLNNLIMFYDSNDVQLSTYTNEVTAEDTAKKYEAWGWKVVSIDGNDHDQIRKALTEANAETEKPFLIIGKTIMGKGCKDADGNPYEGQSELHGKPIGATKASYEKTIEGLGGSLEDPFVIFPDVAETYQEILTRKRAEVKAEKAKEAEWRAANPELSAKLDHFLTGKIPADIDFSAIPQKANVASRDASAAVMGYLAGKVENLIVASADLANSDKTDGYLKNVKAFTPGEFDANFLHAGVCEFSMAAMANGMALHGGVIPVVGTFFIFSDYQKPAYRLSSLMELPVIYLWTHDAFRVGEDGPTHQPIEQEAQLRLMEQLKNHKGKRSMLALRPADTAETTVAWKMALENTETPTGLILSRQGITDVPSDRDRYQDALQAEKGAYVVKSSADAAVTLLANGSEVSTLVEAAALLEKDGINVNIVSVISEGLFRDQPADYQRSVLDSSKPVFGLTAGLPVTLAQLVGANGTVFGLDHFGYSAPAGVLDEKFGFTGAQVYGEVKKYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E055</accession>
    <name>A0A654E055_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="285" mass="32551" checksum="05ECC96164FE4CB8" modified="2020-04-22" version="1">MAKFSETDLIINPDGSIYHLNLKPENVSDKIITVGDPSRVHRVSRHFDKIEFEMNKREFITHTGTYKGKRLTVISTGMGTDNVEILMNELDAVFNINLKTREPKPNPTRLKIIRIGTSASIQNDIRLGSHVMSEYGIGMDPMVHFYQMEMEGLELEVSQALQKEIGLPYLPYCVRGSDELIEQFRDKTVLGNTVTCHGFYAPQGRSLRVPIRYPDLVDKLNYFHVGNFWLTNLEMETAGYYALAKLLGHEMISMNAIIANRIRNKFSKDPNKVVDSLIRKVLETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F8</accession>
    <name>A0A654E0F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="562" mass="65534" checksum="F2107E001E3F6338" modified="2020-04-22" version="1">MMGISKGVMLRFSDLFNDRPPDPRNLLDGLSENTLLKIGPSLIAYDWRDECKSNPVSIFIHFLGKDHPELGPILARFRRLDQKINWRIVNPFASLTLFQDLVEKGHSQGELDSNTVNFNILLYYLLINELMVSTYDTKVLESTENIVPMGVKGAAMYLSQSLRDNDFTNYSIEGIFGASLIKSFKFFEFIERDDFLKPHLQGILENYNIETWRQYLFQLIGIIQFAINQPSPAHFIKISFDPIQANSLLFEDFYFKGKEHEDVDFVTLRSKPLIREGESSFIIVFDLFLAEKLFKGIYWLFKSRMPDKQSHDILKQKVSFDFSEKSLTYDVLDRIFATHFNVHGEDIKIKGFTDYYSRKGSEILLFESKDVLINKLIKSSGDWEQIEADLKLKFLVNKKGERKAIRELLQSVKLVLSNSAQIDPNLENLDKLVFYPIIIVHDRVFDLIGLNTILNYWMYQEMESDNECSPIKNRIRGVTLINIDTLIVNADVIRENPEIFLKSIRKLQDDYRIYASPLRLPISEDQVYQALYPFSWCLEEQIPENTKRSPKDFLETAMRLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K7</accession>
    <name>A0A654E0K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="11"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="275" mass="31231" checksum="799A002F2B0AFA92" modified="2020-04-22" version="1">MKKQAVIYFFLFLLGSFVMAQDFLSWQMNDRYFTAQAGFGFASYRGELKHNGSIQNEISNISLGVEARLLPKVGARIEIGRYSIRGHDRHAPDSSYAQQRNLSFSSTNYEISVQGIFYMKKYAGAYYKRHKVDPYLLAGVGATFISPTAELAGQQYNLYDLQTEDTEYSRFTMIFPVGAGLKWKINPFLNFTTEITYRFTLSDYLDDVSGNYPQNPGQGADLLSNRKDEVGVINQEAYDQLVAGAPRGDQQDKDAYLFLNLKFEFFLPPGLFKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U2</accession>
    <name>A0A654E0U2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sufS</name>
        <name evidence="8" type="ORF">MARINOS108_110034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="29"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="45342" checksum="A41BEBE7AAE4D0CB" modified="2020-04-22" version="1">MSVDTSISVDEIRKEFPVLHQQVNGKPLIYFDNAATSQTPECVTNALIHYYQNDNANIHRGIHTLAERATTAFEETRKAAQRFINAGEAEEIIFTKGTTEGINLVAQAYGRKFLKAGDEIIISGMEHHSNIVPWQLLCEQTGAKLKVIPVQPSGEILLEDFDRLLTDKTKLVSVVYISNSLGTVNPVAEIIAKAHAAGAVTMIDGAQAAPHHQIDVQALDCDFLAFSGHKMYGPTGVGVLYGKRVLLERMDPYQGGGEMIREVTFEKTTYNDIPYKFEAGTPNIADVVAFKAAIEFIEGIGFEFLHQQEMALLQRGKERLYSIDGFTPIGTAAHKTSVISFLIDGVHPFDLGMLLDARGIAVRTGHHCTQPLMDHFQIEGTVRASFAVYNTVEEIDTFAEALSEIVKKFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E110</accession>
    <name>A0A654E110_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22212" checksum="C726E409AAF3B46C" modified="2020-04-22" version="1">MTERILLIFFVFFMSYCGWSQDFSAQINPDKLTIDGKARDGISTSFDFPAKEVERGWWRYSREFGRPLNMRGYYKVTVPSEVNSGNVDIILLSKTLGSKTGCKFFVALDQENVPKTKVAAYNAQIKTILQDFKKAYYIEELGEILGKAEKKAATASKKVSKSNGNGKEKALHELTNYQKQIETIKSQLKIIYQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E152</accession>
    <name>A0A654E152_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="40751" checksum="031E3F5ECE06887F" modified="2020-04-22" version="1">MKNFKIREIHVRWVGIFLVGFLVMFTEQEGTPAAALPFWSHYFVSVAFTAIYWNGAYLLFMWFRKVFPEISQTYKRLFLTYMALFVWMSIGGIPFKMALGLVEYTLSGVFLACSEYFMLNIILAIIIGTIYETVFFFEKWKESIQQNEELKNQQIRTQFEVLQNQMSPHFLFNSLNTLTTLIAENQQVAIDFTQKLSEVYRYILQNKERDLVHLHEELDFAKSYLYLLKMRFPDNLTATFNVDKKYEHLSIAPLTIQMLVENAIKHNVVSKADPLHIDVYVENGSSIVVKNNLQKRPVIEKSTKTGLANIRKRYEYLGNRQIEIITTPKNYMVAIPLIDLIENRNIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B6</accession>
    <name>A0A654E1B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">dnaA</name>
        <name evidence="13" type="ORF">MARINOS108_120395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="160"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="371"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD16847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="468" mass="53519" checksum="760D685538D2A65A" modified="2020-04-22" version="1">MHVETWEKCLLFIKERIPAQSFSTWFEPITPLSMNNQVLTIQVPSQFFYEWLEENYVHLLKQAIKSEIGEGGRLEYSVVVDRGDEQTKPVTVNVSGASHSQNKNRVNGYDAYKNPDFHQELKRNSNLNPSYRFENFIEGDCNRLARSAGYAVAQKPGITSFNPLMFYGGVGLGKTHLVQAIGNEVISADNSKKIIYVASEKFTNQFIEALKNNNLQDFINYYKEVDVLILDDVQFLKEKEKTQEIFFHIFNHLHQSGKQIIMTSDCAPKDLKGLQERLVSRFKWGLTADLQAPDFETRMAIIQTKMQADGIDIPEQVIEYIAYTVDTNIRELEGVVISLIAHASLTKKEMDLELAKQILKNIVTDIDSEVGIDYIQKTVSDYFNVAQDDLKAKTRKKEIVIARQVAMYFSKDYTNHSLKSIGYHFGGRDHSTVIHAVQSVNDMIDTNSKFRFSIDELKKKLKIRTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J7</accession>
    <name>A0A654E1J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">MARINOS108_120475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009034194.1">
        <property type="nucleotide sequence ID" value="NZ_LR734817.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4503" checksum="99CCF9F88010B665" modified="2020-04-22" version="1">MKVKASIKKRSVDCKVIRRKGKLYVINKKNPKFKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P3</accession>
    <name>A0A654E1P3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SusE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025970">
        <property type="entry name" value="SusE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14292">
        <property type="entry name" value="SusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024819348" description="SusE domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="SusE" evidence="2">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="571" mass="61728" checksum="8DAF0A0060F1FBDA" modified="2020-04-22" version="1">MKNIKLLVAFLMVFMGLTACEEEMEKAMIKQEITANSLNEMSSADYTLTFESRSEVFEEFAWTAPDFGFEASITYTLQMDTAGGSFAKPFSFPTTQALTVSPTVNAVNAALLGMGLDPDVAAEVQFRVMSSVNPNVAPVYTNVVSANVTPYLATFPPIYIIGDAQGWNLGNALEVTSTGPGTYEAVGLFQADGKFRFFATPSWDAEQWGWSFFEGGTVASELASGEDGDSNFLFGGATGVYKISVNLNAKTITLEEGELPTLFVIGDAQGWNLQAALELTFLGGGKFEGTGTFQDGGYFRFFEKADWAATQYGYSYFDGGTIPAEFTDGGDGDSNFIFAGSTGEYTVSVDLNSKEISLEVATQYPAALYLVGDDQGWSFANSPTFTNLGGGVYEAEGVNFTKESTFRFFEEADNWSDDFGAGFFTGGIDDELAAVGDNDDNFSFVGESGLYTITVSLSDMSIVVEPYSAYPSSLYLVGDDQSWTFANSPVFSSSTPGVFEATGVTFTNGSTFRFFEELDNWSDDFRYAYFTEVSSDLEAAGDNDDNFKFIGTDGAFNITVDLTTKSVQLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T0</accession>
    <name>A0A654E1T0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pbpC</name>
        <name evidence="11" type="ORF">MARINOS108_20083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011815">
        <property type="entry name" value="PBP_1c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009647">
        <property type="entry name" value="PBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06832">
        <property type="entry name" value="BiPBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02073">
        <property type="entry name" value="PBP_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="9">
        <location>
            <begin position="66"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="8">
        <location>
            <begin position="301"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="BiPBP_C" evidence="10">
        <location>
            <begin position="678"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="772" mass="86292" checksum="52142D5B6500D270" modified="2020-04-22" version="1">MLSGSGDRRSKIKWAAWLSPLLALGIYLAIPPSLGNRPTSTVLNDRNGHLLSASIAADGQWRFPLCDSVPVKLERSILLFEDEYFYYHPGVNPLSVLRAIRQNIRQQRIVSGASTLTMQLARMLQNEKRTFFQKLREVGIALRMELWYSKEDLLRHYASLAPFGGNVVGIDAASWRYYGRPAHLLSWSESATLAVLPNQPGAIYPGTSMEALRYKRDFLLKKLYLSADIDSLTYALSLEEPLPDKPFDIPQRAPHLLTTLRENAEGRPQTTTLHPFWQQKTTEVAERKHRWLKSSGIDNLAVMVVDLRNGQVLSYVGNTTDPTADGYQVDVIQKPRSSGSILKPLLYARSLEKGIMLPKTLLPDVPSSFGGYTPKNFNLGYAGMVKANEALSMSLNIPFTHLLQEYTYEVFHQDLQKFGITTLTQPPGHYGLSIILGGGEVKLWDLAQAYFGLYRKLANEDNLSISYLPDSQKIADVELSEINVWHTFQAMTELTRPGADHSWQNFSSSQLIAWKTGTSFGFRDAWAIGLNGNILVGVWVGNADGEGRAGLSGASSAGPILTELIRLGEYDGQWLEKLRPFSFPHQTCTASGMLAGPACEHTETMELGPQAEQSGLCTYHQRLWMDESNTYIVNHSCYDMHKASLQSVFVLPPKQGYYYQKNHSDYSGRPPIYPGCEQQVENLLAINYPSVNAKIFIPKELQGQSSEVILEGSHQNPNAELFWHLNDRYIGSTHGEHKQSLLLPRGAYLITILDEQGNSTSRSFEVVSDPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U0</accession>
    <name>A0A654E1U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="21142" checksum="7F09A0134ED66076" modified="2020-04-22" version="1">MSKESDEQLMLAVQTGALEKLNVLCERYQKRIYNYCLKSVLDADDSADLTQNIFIRVLKYRKSYKAGSNFEFWLFQIARNQVKDHFRKMKVHRDQFQAADVLPDRADDSDEEQREREQRLMQALSLLPEEKRELLVLSKFEGMKYEQIAALKSISVSAVKVQVHRTIKQLKELYFEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V1</accession>
    <name>A0A654E1V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="183"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="28898" checksum="8E12473927066A47" modified="2020-04-22" version="1">MGFGHLRSNFIIHFHTVFSFHKLLAKFGRSVNRMEQQSISILMADDHTLFRKGMSMMVKTFPGITSVKDVENGQKALDLLAIEKFDILLLDLEMPVLDGWETAKKVVTKFPDTHIIMISMHDSLKLISDLIEIGVHSYLLKSAEPEEVQKAISSVMNNDFYYNQLVARALHQKVQKGAINKPLFNEKSQLTKREVEILELICQELTMKEIGDRLFISEQTIHTHRKNLMRKTEAKNAVGLVKFAIQQQIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A1</accession>
    <name>A0A654E2A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmE</name>
        <name evidence="4" type="synonym">rpmE2</name>
        <name evidence="5" type="ORF">MARINOS108_20315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="82" mass="9643" checksum="807E20E441C66BD7" modified="2020-04-22" version="1">MKKDIHPEYKEVVFLDTTSEFKFITRSTMTSNETIKWEDGNEYPLVKIEVSSASHPFYTGKKIFLDTAGRVEKFNKKYKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B5</accession>
    <name>A0A654E2B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding universal stress UspA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="154"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="31397" checksum="4AEEC66D4A4A2FB9" modified="2020-04-22" version="1">MKIKNILVPIDFSECSKNALKIAIGLAKDFGAKIHMVNAVHVHHPHPDFIGGSLMDSIMADYENQVKESFEELESEIIELNDVPHEADRFISYLTDAIYSESERKNIDLIVMGTRAHHDKIEHLIGTRATDIIESSKVPVIVIPENVKTFKLKKIGFASDLSEVKNFEKLKLIGTLARHFDASVLIFSIVEDPEKLTAMDQKLMREISERFKDVNCSARTVQADSIKEGIVKFAAFHELDLLAMIPRHRSFFERIFRSSVTKNIAIDADIPLLSFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E6</accession>
    <name>A0A654E2E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="4785" checksum="85F2593CD2D49EF6" modified="2020-04-22" version="1">MASKLFELRMIGDDFSSHGGDSKFMKTHPLIPSQEGKLSLNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F3</accession>
    <name>A0A654E2F3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-fucosidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025018821" evidence="1">
        <location>
            <begin position="22"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="831" mass="93303" checksum="8CAF1CA966F83103" modified="2020-04-22" version="1">MKIFKHILSCGLVLLSVAVVAQDNMKLWYDKPAPNWNEALPIGNGRLGAMIFGVPERENIQLNESTLWSGGPHRNDNPGIRENLTQIRQLLFDGNYKEAHEMANAKIISNTSHGMPYETAGNLYLKFEGHENFTNYYRELNISEAIQRTSYTVGEVVFQREVFTSFSDQVLVMRLTASEPGQISFTSTMDRPKPELVTVSTEGNDLLKMAGRNNDRKSKRLPEAAEGTKGKIKFETRVKFLPEGGELIAGDTSLTVRNANSVTVIVSIATNFINYLDVSADEHERTQGYLSATNGKSYEALKRAHTLYYQQFFDRVTLDLGQTEEANKPTDERIKNFSAVNDPAMAALYFQYGRYLLISSSQPGGQPANLQGIWCNDLNPPWKSAYTININTEMNYWPAEVTNLPEMHEPLIEMVKDLSVTGQKTAAEMYGADGWVAHHNTDLWRITGAVDGATWGIWPSGGIWLSQHLWEKYMFSGDLEYLREVYPVMKGSAKFCLSFLTPEPEHGWLIMSPSTSPENRPTHFPNMVNIQYGATMDNELVFDMLTRTASAARLLGEDEDFIKEIEETLPKLAPIQVGRYGQIQEWIKDWDDPKDKHRHVSHLYALQPSNQISPYRNPELFEAAKNVLIYRGDPSTGWSMNWKINLWARLLDGNHAYKLMGDQIKLVGRPNAPKGGGTYANMLDAHPPFQIDGNFGFTSGLAEMLLQSHDGAIHLLPALPDVWQDGRVTGLRARGGFVIESMEWKGGQLVEAKIRATLDGNLRVRSYNQLTMAGKKLKKAKGQNVNGFFQTPEILDPLISDEANLKGYEPPMSYLYDLPANAGEVIVLVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I4</accession>
    <name>A0A654E2I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="532" mass="58079" checksum="6D2330FF931B4B8A" modified="2020-04-22" version="1">MLVFSASGQSNDAVSLNLENASYQSVFQTLTTLTGKKFAYNSDLIPDKPVNVKAEQEPLALVLKKILGSELSYVERGHYIIIVSAEKPKKQVSVTTQGEILDADTHEELAEVSVYEVNRLTSAMTDHFGKYTLTATVPDEVAFIAISKANYQDTVIQVSAKDRFFTVLLKPIKEIQQQNPTDTLKLVQFFARNKVRKHANNVSLTERRLAQVSLTPGLSTNGFISGKISNVVSFNIIAGYAHSLHGVELGGFINMERMEGSGLQMAGAINIVGSHFHGNQWAGASNITLQDMAGFQAAGFSNHTKKVVGFQMAGVLNTASETRGLQMSGFANHTSGTLKGIQLAGFINRTGTLKGMQIGIVNLVKEVESGFSIGLINLFKDELHQLEASANDITPYNLSFKSGLHHFYSIISAGIDPHAGQLWSYGLGFGTQRALNQVLLASTELSINTLQPLNSAFMDGFNSDLRWALRIGGQLTKKISIHGGPVLHYYFFGRHGQNPEFSDRFGTNTLYQKTDGNALTKAWVGYEAAIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J2</accession>
    <name>A0A654E2J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA 2-selenouridine(34) synthase MnmH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mnmH</name>
        <name evidence="3" type="ORF">MARINOS108_20472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043828">
        <property type="term" value="F:tRNA 2-selenouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017582">
        <property type="entry name" value="SelU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03167">
        <property type="entry name" value="tRNA_sel_U_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="38448" checksum="6FDFAC8514CF936F" modified="2020-04-22" version="1">MKQLDPQEFLSLGEKLPIIDVRSPVEYEQGRLPNALNMPLLSDEERVIVGTLYKQDSPQAAFKRGLDFIGPKMSGFIEFAEGLQSQELLVHCWRGGNRSHSVAMLLETNGFNVSILNGGYKAYRREALEFFDQPLPLMVLTGYTGSLKTEVLYALQELGEQMVDFEGLACHQGSAFGRQESEEQPTSEQFQNLLFQEFRKLDLTRRIWVEDESMRIGRVDLVAELYHQKEQSPHVFLEVARPVRVKNLVLNYRHVSLERLVLATKSIQKKLGKKEARQALEFIDHGDAPEAAAIILKYYDKRYGKSIEGKRDHIRLHLETQSSDPMQIAQEILSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L3</accession>
    <name>A0A654E2L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="5423" checksum="1EB160EB3A97B99F" modified="2020-04-22" version="1">MRHFPKVKCRLNDWEFISSDAIRLIVTFDLNSGRFLERLFHGDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R1</accession>
    <name>A0A654E2R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">MARINOS108_20542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="508" mass="56161" checksum="5007010B15AB6922" modified="2020-04-22" version="1">MSEVKIKSALISVFYKDGLAPIVEKLNELGVKLYSTGGTQKFIEDMNVAVTPVEDITEYPSIFGGRVKTLHPKIFGGILHRRDYEGDQKEKEQFEIPAIDLVIVDLYPFEETVASGASEEDIIEKIDIGGIALIRGAAKNFQDVLIVSSRNYYGDLLDLLNNKNGNTELADRKLFATRAFDTSSHYDSAIFTYMNRDNSVPSFKVSGANGKVLRYGENPHQQGVFYEESESYFDQIHGKEISYNNLVDIEAAIQLIGEFKDETAFAILKHNNACGVATGNDVKTAYQKAFAADTISAFGGVLICNQEITKEAAEEMHSLFFEILIAPAFSDEALTVLQQKKNRILLVQKKSWNREKIHKSMLNGTLVQDYDNITDNEEHLKVVTKVAPSTEDVKSLLFASKVCKQSKSNTIILAKDGQLYASGVGQTSRVDALEQAIAKAQKFGFDLQGAVMASDAFFPFPDCVEIADKAGIKAVIQPGGSVKDQLSIDYCDQNGMSMVFTGTRHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S3</accession>
    <name>A0A654E2S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15871" checksum="EBD058A289BD1C2E" modified="2020-04-22" version="1">MDNFKSHLQSLIQLAVSDQNFNEDEKQLIYSIGKANKVEESEIDALIHENISRKGEVDISFSALSFDEKFQFLYNIIQLMKIDSKVFLSEIKYCEDLAQRLGFDKKVVKKLSSQIYSNPSITGNRDKLIKEARKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S9</accession>
    <name>A0A654E2S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_10340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="238"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="271"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="998" mass="114635" checksum="95A9188D7E20C43E" modified="2020-04-22" version="1">MSEEILNAILQLLAIVAKEDDVTSAEKASVENFLVSKLTAERAKKYLLFFDELTKKQHYSDSDETQIAEICAKINKEQTAQQKIIIILDLIILIAADGKVSNRERELLYLISESINISKAITDLIKAFVIFQERSKISSRHVLIIDDGTHEVPDKCKRLIRQGLDGFILVLSVPEIDIYLAKYIGERPVVLNEGPMRINHIYNFASGSAIKFENAEPIYHSEVVNSFRSIASDHHLTFAAREVTFKFKNGKVGLRNINIEEESGRLIALMGGSGAGKSTLLNVLNGNERPSEGTVRINGVDIHKNRRKIEGVIGYVPQDDLLIEELSVFDNLYYAAKLCFKKLNEEELQQLVNKTLESLGLYETRKLRVGSPLDKTISGGQRKRLNIGLELLREPSVLFVDEPTSGLSSRDSENIMDLLKELSLKGKMIFVVIHQPSEDIFKMFDKLIVLDVGGYQVYYGNPIDGIAYFKDIVKMVDQSKAANPEQIFNIIETKVVNEFGNFTKERKITPYQWYQYFKERINIPPVEETPVIPHKTLDIPNKFKQLKIFSIRDFKSKLSNTQYLTINLLEAPVLALLLAFIVRYLPEDTSFYQFRENLNIPVFFFMSVIVSLFMGLTVSAEEIIKDRKILKREAFLNLSRFSYLVSKLIILFGISAFQTMTYTLIGNWILGIQGMFFPFWLVLFSISCFANVLGLNVSSAFKSAITVYILIPLLVIPQLILSGVVVNFDKLNPAITTEDKVPMIGEIMASRWAFEAMAVHQFKENEYEKYFYEDDKVMAQSEFKTAYLFPRIEEDLKQIHHNMGAASEEEKEEYAYQLKTIQNELKKELSEIGYDKFPEVDQLNVDQWSESLFHETMVFVEKLIKYYNLQYKDANSSKQALLADLNSTPEKQARFESLKNENANVAVGVMVKNITTEHRILEHNNHYIQKLYPIYNDPSFPDHALDFRAQFYQPTKHFGGLWIDTLIFNVIIIWMMSLGLFVTLYFDWFRRIIAFISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W4</accession>
    <name>A0A654E2W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2Fe-2S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="106" mass="11735" checksum="D82B4DF913A9CE63" modified="2020-04-22" version="1">MPEVTIKNLNSKTIHCNSKTEKLLDILLTETDWMHACGKKGKCTTCTTEILAGQDALSGYTEAERRFINLGRLKEGDRLACQAEVHGNVTVKAPGAYKLPHIDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E311</accession>
    <name>A0A654E311_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA</name>
        <name evidence="9" type="ORF">MARINOS108_20236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="205"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="49966" checksum="96A0DBDC4CE45FF0" modified="2020-04-22" version="1">MANHSKKVDEFIQRISQRNPHEKEFIQAVKEVAETIVPFIEDNPKYKQTNVLETMCEPERVVMFRVPWVNDQNQVQINRGYRVQMNSAIGPYKGGLRFHPSVNLSILKFLAFEQVFKNSLTTLPLGGGKGGSDFDPKGKSNGEVMRFCQSFMTELSKHIGGFTDIPAGDIGVGGREIGFLFGQYKRLRNEFTGVLTGKGLQYGGSLIRTEATGYGVVYFSKEVLESHGNSLEGKVCAVSGSGNVAQYTIEKLLELGAKPVTVSDSGGCIYDKDGFNEEKLAFIKELKNEKRGRISEYADQFKGSEFHADVTPWNFKVDLAYPCATQNELPLEDAQLLVKNGCIGVFEGANMPTTDEALTFIREKKIFFSPGKASNAGGVATSGLEMSQNSQRLYWTRDEVDYRLKMIMKSIHNNCEEYGRESKDYVDYVKGANIAGFVKVADAMIAQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C5</accession>
    <name>A0A654E3C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="284"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="610" mass="65631" checksum="F4701243C7F74E4D" modified="2020-04-22" version="1">MNDFLIFTLAILAAGSILFGANYILLKQSFLYWIGVVLIVFTCAIALITMLVGVFGIQYLFLTIPLGCGFGVIALLAIIRVVRKPFREMSGYLNAISTGSMAIENSSALEKDAETGGLFRQLHAYLQRIDHVSVFASEIGNGNLEVEFISAGENDLLGNSLIKMRDNLKAVIDDSKAVVRQATEEGKLEARIETTGKEGAWRELGEALNSLLVSFSMPLLRFNTIINALANGDLTNRYDDQAKGDILEMTQSLNSALSNIDALLSQVAQNATIIEESSSDMRVSGEEMSSNTNEIASSIAEMSNGAHLQVNKVDDASSLMEGILNSSKEMGHKAETIHNAAKMVAENSKKGNVMIDEVVANMGQIAGFSDKTNDSIKVLTERSREISRVLGVITEISSQTNLLALNAAIEAAQAGDAGRGFAVVAEEIRKLAEDSKKSAREIEALVMDVQNDTLKASDAMAQMSTSVKSGETTSRAAADSFKVIHDSSHLNLEISEEILNATQNQILDINNVVNITEGIVVIAEETAAGTEQIASSAAELSTGMEVYNQKIQKLAEVAESLKAGVSILKLSGQHHSLDIAPNQEKESVLLDSLVDTDGELEYEELDQKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C6</accession>
    <name>A0A654E3C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pheS</name>
        <name evidence="15" type="ORF">MARINOS108_20583</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="107"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD19118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="337" mass="38722" checksum="2C2F636110D36EB2" modified="2020-04-22" version="1">MKEKIGTYIEAIDKAIAKNKEELEQFRLRFISRKGVLTELFEEFKKVPNEQKREIGGELNVLKQKAQEKFQELIDHVNGSSMSDAGAQDLDVTLPPIVEEGSVHPLSKVKNRIIQIFERQGFSVKEGPEIEDDFHNFTALNFPENHPAREMQDTYFISKNPDVLLRTHTSNVQIRLMEQGKPPFRSIMPGRVFRNEAISARAHCFFNQVEGLYVDKDVSFKDLKQTLYHFAKELFGEDTQIRFRPSFFPFTEPSAEIDISCFICKGDGCKICKHTGWVEIGGSGMVDPNVLKSCGIDPKEYSGFAFGMGIERITMLKYQIDDIRLFSENDLRFLKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J6</accession>
    <name>A0A654E3J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="351" mass="39819" checksum="EF37B166DFFD1AED" modified="2020-04-22" version="1">MIDKKNIRIKDIAQMAGVSVGTVDRVLHGRGKVSKDAQQKVEDVLNRTGYKPNLIARTLGSNKTLKITALLPDPAQDDYWALAEAGILQSIEEWSYYDVEINCIFFDLYNPGSFKKTTDVVLESKPDGILIAPVFHHESIELLAQLKAHSIPYVLFNTNIPEADPLCFIGQNLVHSGKVAGELLSLAGGTRRTIMSLHIYENRDNSVHLMAKEHGLRQYFQEQPYEVISLDLSTPHEVEDHIREAILNPDLLGIFVTTSKGTYIVAQILEKYSLEHIRLVGYDLLEENLRYLKKGTIDFLINQNPKRMAKIGVNHLVNHLLFQKTLPEKEIFPIEIITRQNLDSYLTSRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S5</accession>
    <name>A0A654E3S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aminopeptidase FrvX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="303" mass="34119" checksum="2F7A39E2AA80F273" modified="2020-04-22" version="1">MKLLEQLIDIPSPSGSEYLMRDFITQYVRKHSHSWKVQPKILSGDFLQDNLILVFGEPRTAIFAHMDTIGFTVRYHDQLVPIGGPDVENGYELVGRDSKGLIQCTLRVDDEGQLFYDFPRAIETGTTLTWKPALKVGEGFLEGPYMDNRLGIYNALKVAEHLTDGVIVFSSFEEHGGGSVPMLIKYLAENYSIKQCLISDITWVTEGVQHESGVAISMRDRNIPRRKFLDRVLELAAESGIAHQLEVEGGGSSDGREIHHSPYPIDWLFIGAPEDNVHSPHERVAIKDLTAMIAMYIYLMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U8</accession>
    <name>A0A654E3U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019868">
        <property type="entry name" value="Glid_motil-assoc_GldJ-short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03530">
        <property type="entry name" value="GldJ_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025033303" evidence="1">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="360"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="441" mass="49322" checksum="666AE9AB2D08787C" modified="2020-04-22" version="1">MKKFVSVVAGSGSVLAMAIVLSSCGSGTPTSTNPGAISKTTGLEFNEEGGFQVNDFSGQPEGPNLIFIEGGRTVLGTFEEDVLNTNDHVERAVTVASFYMDETEVANINWLEYEFYIKQDSDEYYWKNNLPDTTVWAKDLAYNDPYVDHYYRYPGFRYFPVVGVNWRQAVNYCKWRTTVVNVSLAERAGLYDDLGGGGGDAAFAGAEGEPAAAGAFPRIPLESGVVLPNYRLPTEAEWEYAAQALIGTQWLDENQTHRRLYPWDGHALRNPYGKSMGYFLANFKRGKGDYAGIAGKLNDGAMIPTYVYDYPPNDFGLYNMAGNVNEWVQDVYRPLSYQDMEDMNPVRRDGTLDAESGYDGAYNFIGNETTYTEEEWLSKTGLQKSYNSDNPPMKRLRVYKGGSWADVAYWMSPGTRRFLFEDSATSTIGFRCAMIRAGTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V6</accession>
    <name>A0A654E3V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide export outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="29930" checksum="ACB4BD4D7D97D458" modified="2020-04-22" version="1">MIFNISTIRWLFLGCVVFLSSCKVYKQDIMFRLDDNFTEEDLSEPVKKAEENYLIQVNDYIELNLFTNDGERIIDPNPEIFSGNNNLNNRLNSRQQFEYLVQVDGVVKLPVVDRVNLAGLTVNEAEIVLQSAYNEFYKDCFVKIKVNNRRVVLLGANGGQVILLENENVTLAEVLALYGGLSLGAKANNIKLIRGDLSNPMVYQMDLTTIDGMRSTIIKVEPGDIIYVEPWRRPWLAGLRDVSPILSITSSVIAFFLLIQSITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z3</accession>
    <name>A0A654E3Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="244" mass="28187" checksum="1C3FE2820A74D68F" modified="2020-04-22" version="1">MHKYLKGITLKDLLIFENDHYLVINKPPYISTLDDRNDPVDILKLAKEHHADAQVCHRLDKETSGALVIAKHQEAYRHFAIMLERRQVKKVYHAVVGGIHEFDNVSADQPIYSTNSKSRVDFREGKPSLTLISTLETFKYHTLVKCFPVSGRLHQIRVHLAFHKAPISCDPVYGGEYIYLSGIKKNFNLSRHTDEEKPILPRVALHAHNIAFYDFDANEERTIEVEAPYPKDFGVLIKQLRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B4</accession>
    <name>A0A654E4B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsI</name>
        <name evidence="8" type="ORF">MARINOS108_20933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14538" checksum="4E2CD3F862B0A334" modified="2020-04-22" version="1">MEITNTIGRRKTSVARIYLQSGKGAITVNNKDIATYFPSEILQTIVKQPLVTLQLDGNYDINVNVDGGGPKGQAEAVRLAISRALVELDEENKPALKKEGFMTRDPRMVERKKYGRRKARRRFQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C2</accession>
    <name>A0A654E4C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09024">
        <property type="entry name" value="Aldose_epim_lacX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037481">
        <property type="entry name" value="LacX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="33420" checksum="6AEDC6B7BD6719CC" modified="2020-04-22" version="1">MKISNNHLKATFNVRGAEITSLTHNATGREYIWQARTKYWGRHAPVLFPFVGKLKKDQYRHEGKTYEMGQHGFARDLDFEIVEHTSDQIIFQLDADSNTLKKYPFRFELRIIYQLEGHSLRTTYEVKNKGKQVMYFSIGGHPAFDCPLNPEEFRSDYWLEFDQQETLFTHRLDGGLFTGKKEAIDLDGQRLHITDHLFDQDALVFKQLNSTRVSLSSLSQKWLTFHFEGFPYLGIWSKSQESPFVCIEPWYGLADYGDHSGELSAKEGIRKLDASAIFSCHYTMEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C5</accession>
    <name>A0A654E4C5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspC</name>
        <name evidence="3" type="ORF">MARINOS108_20716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="43281" checksum="9442CE117290F89E" modified="2020-04-22" version="1">MDLRSERIKNMAESATLAMAAKARELKQNGVDVISLSLGEPDFKTPKHIQEGAKAAIDEGKYFAYPPVNGYLDLREAISAKFKKENGLNYSPDQIVVSNGAKQSIANVFLALLDPGDEVIVFSPYWVSYSALVELAEGKCVFVNGDLEHDFKATAEQLKASITDKTKALIFSSPCNPTGSVFSQEELEAIAEVLKEYPNIVVISDEIYELINYGEKHVSIGAIAGMEDRTVTVNGFAKGFAMTGWRVGYIGAPLWLAKAANKMQGQITSANCSIAQRAALTALTSDYEPSYKMVEEYRSRRELVYGLLSEIPGVEVNMPGGAFYFFPNVSSYFGKSVNGKVIADATDLSLFLLEDANVSVVTGEAFGDPRCLRLSYAASVEDLKTAMSRMKASLAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E5</accession>
    <name>A0A654E4E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="472" mass="52509" checksum="1360A415FCC4BDE2" modified="2020-04-22" version="1">MKPYLHLLLAIVILSCGDHSTVDPEQPTDSADTLTIFFINDQHGQLSNFAKIKHIVDKEKATNEHVLLVCAGDMFSGNPIVDQYEKKGYPMIDIMNKTGFDVSVLGNHEFDYGPSHLKDRVLQAEFDWVCANVDMKNSGVPQPDPFKTLTIGNLNVTFLGLVETFGKPGAIIPATHPWRVTEMQFRRHTDILAKYRTLKEDEGADVFIALTHLGTQNDLELAEIFPELDAVIGGHSHQKVNLTINETPVVQAGSYLALLGRLDLIVDKARITSSDVSFIDLHDYAERDQELADLIATYNNAPQFNEVIGVALSDHDRNELGCFYTTALMDYLQVDMSFQNGGGIRSGIDAGDITTLEIYNMDPFNNQSVIFTMTAQEVSDFFTESRAGVHVSGVDFQQNGSTLVLYKDGKAIPPEDLVTIGINDYIPAVYDQYFPLEKAEIQGLTTAETIIAYLKTINSTLDDEGCNRYFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K5</accession>
    <name>A0A654E4K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="479" mass="53992" checksum="823661867A977770" modified="2020-04-22" version="1">MSPVFVGGIILSYFLLLIVISWLTSRNATDSDFYNANRQSPWYLVAFGMIGASLSGVTFISVPGEVGNSNFYYFQVVIGYLLGYFVIAKVLLPLYYRLNLVSIYSYLEQRFGFWSYKSGAFFFLLSRIIGSSFRLFLVASVLQISFFDAFNFPFWVSVLVTIVLIWLYTFQGGIKTIVWTDTLQTAFMIASVVISIVFVTNELDWSFSEMIGHIAEDERSNIFNWEWQSGRNFFKQFFAGAFIAIVMTGLDQDMMQKNLTCRSLADAQKNMFWFCIILVIVNFLFLSMGLLLFQYSEAIGVSIPARTDFLFPELAINHFSTLGAVVFLLGITAAAYSSADSALTALTTSFCVDFLGFSPKNYRQKKTLRKLVHLGFSFVLFLVILVFQAINDQSVITAVFVAAGYTYGPLLGLFALGIFTKYDLRDELVPVICLLSPVISYIININSESWLGGYKFGFEILILNGLLTFIGLLLIRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S8</accession>
    <name>A0A654E4S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032342">
        <property type="entry name" value="DUF4861"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16153">
        <property type="entry name" value="DUF4861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024987070" evidence="1">
        <location>
            <begin position="22"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="44110" checksum="A5C9DBE2FC66F3C1" modified="2020-04-22" version="1">MKFIPILFFGLSCLFSCTSDAPMASIAIRNPSDLARKEVIEVALNVDGEKPLQGQLNGRTVPTEFIDENEDGIIEKALVLLELEPGETANLEVVTSDGSANFTKMTQAELSVKQGGAWTEKEYIGGSFVNLDFLRVPDQHTDHTYFVRYEGPGWESDQMAYRFYLDWRNGMDVFGKLKPEPVLQSVGLDGFDSYHELSDWGMDLLKVGKTLGLGSIGKFRNDTLHRFRVVDSVTCQIVKNGLLESAISTNYYGWADGGNRTDLMSAISIQAASALTTHSIRFTNPIEGFCTGLVKNVGEEYVNEVVDNYHIFATYGKFSLNDDKLGLAVIVETPSISEVVDGAGSHVVLFNPSEEVTYHFMAVWEKGTNPIQSMDSFMALLRQEVLRLNQPLQVLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T4</accession>
    <name>A0A654E4T4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ORF">MARINOS108_60009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="541" mass="60461" checksum="F0332D1E3E321F0F" modified="2020-04-22" version="1">MLEFGIKSKKSGLTESGIKQVKEAWWNLDPSQLTEIALQNREGTLSDTGALMCDTGQFTGRSPKDRFIVRDSKTENAVWWGDINIPISPDSFDRLYAKMLGYLADKKVYVRDAYAGADKTHRIKLRVINTVAWHNLFCFNMFIRPERYQLETFVPNFTIINCPGFLADPETDGTRQENFSVIDLTRRIILIGGTGYSGEMKKGIFSVLNFLLPLEEGVFPMHCSANMGIKDRDTAIFFGLSGTGKTTLSADPERLLIGDDEHGWTMRNVFNFEGGCYAKTVGLSHEKEPEIFNAIKFGAILENTRFLPESREVDYDNVEVTENTRVSYPISYIPNAVEPSIGGIPKNIFFLTCDAFGVMPPIQRLSTAQAMYHFVSGYTSKVAGTEDGVKEPTPVFSACFGAPFMPLHPAEYAKLLGRKLEENHTNVWLINTGWTGGPYGVGSRIKLKYTRAMISAALSGILDNVGYRTHSLFGAEIPTSCPGVPAEILSPRETWKNDQAFYQMANKLVLKFHKNFDQFRGNTGADILLGEPKVNEQYQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T9</accession>
    <name>A0A654E4T9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ORF">MARINOS108_120512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7447" checksum="94172C902417635D" modified="2020-04-22" version="1">MDKVISFFKEAYDELLHKVTWPKYADLQNSSILVLVASLIFALMIGLFDFGFENAMKWFYNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X8</accession>
    <name>A0A654E4X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="43733" checksum="96596F39AA8FB8CE" modified="2020-04-22" version="1">MNILRTTLSLLGVTIGIFAIIAVFTLVDSLERSIKDSLNFLGTNNINVEKWPYGFGGGPYPWWKYMQRPYPTYDEYKFLRDNVKNAQGMSIFTVRGGVTAKYESSSSVDLDLLGVVHGHKDVYEIPIEKGRYFTPQEAEAGRNVVILGFRSVKELFPNQSPIGKSIKIKGLKYHVIGVIKEEGDGFLGAPSNDENIYMPYRSFLKIYYSGQRSGVESHITVKGLDKDIGLVELEAELRGLMRKKRSLKPKEEDTFALNRPEAIANFIGSTFDVIGLAGWVIGGFSILVGGFGIANIMFVSVRERTHIIGIQKSLGAKNYFILFQFLFESVFLSVIGGGVGILLVWLLSFVSLGSLDLVLSLSNIVLGLGVSAIIGMASGIIPAAMAARLDPVIAIRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z3</accession>
    <name>A0A654E4Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="17438" checksum="31804DB78D4BAEFE" modified="2020-04-22" version="1">MDRPAFDDIFMELAVNLAKKSHCIKRHVGAVLTKDTRIISIGYNGPPAGTHNCDEEYPETGCPRDSKGGCSLAIHAEQNAILYAVKNKATVEGSTLYVTLSPCLACARIIYTAGIVKVIYLNSYAAHKGIEQDEGVDFLSKFGVTMEKYQGQISHVTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5J8</accession>
    <name>A0A654E5J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21509" checksum="39EB99639744B026" modified="2020-04-22" version="1">MAEYKSFEDNIEAGGNELPIIAMGSLGQNQRKAIIEKHGLNANTGAWNNLQSLLDAMKEVASTIGEMNLFLIGKAIIEGTQFPPMDSLENALRSIDVAYHMNHRKNGQPMFNPNTGQMTEGIGHYKLARYDAENKEALLVCHTPYPAKFEEGLVVQIVRMFKPKDSLFTKVKLDETKETKSNGGDSCTFIINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5P8</accession>
    <name>A0A654E5P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024859972" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="41"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="274" mass="29318" checksum="0288F48D03586709" modified="2020-04-22" version="1">MKKSIIICIGLFAAVAALAQEKFSEQFTIPLSKPGAPARIELDHLNGDITVTGYSGSEVIITASASGSSLQHGCDDCHEDKKSAPPGMKRVNANPMELRAKESNNVVSIESDSWKRRMNIEIKAPIKADLDLNTVHGTITVKGINGTMEISGVNGGIALENISGSVVANTVNGDVKVTFKSLTAGEPMSFVTLNGDVDVTLPANAKATTKLRSERGEIYTDFDMALERSKTNVKKESGEYEVSINSWVYGKINGGGPEFTFKNMHGSIIVRKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5R4</accession>
    <name>A0A654E5R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="20978" checksum="9DA3BE2D3C671E3A" modified="2020-04-22" version="1">MDFNFSDWWNSLTTLQQIYWGFAIPFSLIFLLQMIMTFVGGDMDTDGSADFDVETDDGAGFQFFTIKNFVGFFTLFSWTGIACLDSGLSGGLSVVISIGAGILMMVIMAAIFYYFSKLTDSGNMSAKNAIGGIGEVYLPILSGRSNIGKVSIKVQGSLRELDAITDDDQDLPTGAVVTVTDITSNDTLIVTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E635</accession>
    <name>A0A654E635_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024849085" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1072" mass="114207" checksum="C7F2B3BDBBE76107" modified="2020-04-22" version="1">MKLLSNILSILMLCTLSVTGAWSQDDPNQPAVGEWTIYNADELPDAADPAWSASNGSGTTWSIESDPIRVGNNLLALDGADASGMYKTADFDPVPTAVTVVMRVKGKDLTADRLTDIDMHINGFRDQLNIRSSGELSLQRSGASVDLSGLLNTSQWNVYRMTIDASSGTEGVVKIYLNENPFPVLSATTTTTTGSNYFRFGDGNGSPTYSAYVDYVSYDVTGAFSPAQTRLPNDLTKPPVGAWTIYHADQLPDAADPAWSASNGSGTTWAIESDPVRVGNNLLALDGADASGMFKTSDFDPTPTGVTVVMRVKAKDPSADRLTDIDMHINGFRDQLNIRSSGELSLQRSGASVDLSGVLNVNKWNVYRMTINASSGTEGIVKIYLNENPYPVLTATTTTTTSSNYFRFGDGNGSPTYSAYVDYVSYDVTGAFSPEQTRLPNEVTKPPVGEWSIYNANELPDAADPAWSASNGSGTIWAIEADPVSVGNNLLTLDGADASGMYKTSDFDPVPTAATVVMRVKAKDLTADRLTDIDMHINGFRDQLNIRSNGELSLQRSGASVDLSEELNVSQWNVYRMTIDASSGTEGIVKIYLNENPYPVLTATTTTTTGSNYYRFGDGNGSPTYSAYVDYVLHDVTGAYSPSQSRLPAQFTGDDEGPTPVITAPAALSEFVQHLGTPTAAKSFSVSGSDLSTDLTITASSGYELSLSETDAFTTDPLVLSNIEGTVAETTIYVRLNSTELGAFNGAVTLVSGSTTKAVSLTGMTIVPEISVSGALEPFKESVSSVSESQSYSVTAVYLVADLTITAPDSYEVSLDNTTWSGMVSIAPDSEGVINSTSVYVRLNGTETGQYNGNIVHSSTGATDVLLAVTGETIPDPGIIASGEFVAFSQNLNQPSDPQSYTVSATNLASKLEISVPQGFEISFNGELWLSSLSLAPLDGNVASTTIYIRLNAPTEGSHSGSLVHSSVGVDAVSFSLSGSTAAGVVLGATFDDDLFKMWPNPATDRIFIRGKVLQNNQQLSLYTLGGVRVNSYKLLQNNEGVELDLTNLSQGMYVIELTNEGKKVTKKFWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6B1</accession>
    <name>A0A654E6B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024791948" evidence="1">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="17699" checksum="D6D7EF755BE74DF8" modified="2020-04-22" version="1">MKYCHARIIVISLITFLLATSCQKVSQQKALSSPPLTGTWKLLTGTIIQGKDTTITNYTINQELIKIINETHFAFLRHDLGEDSTAIFVSGGGRCKIDSKNYTEHLDFCNYREWENNTFEFEYKITGDTLTTIGIEKIDDLGINQLNIEQYLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6Z3</accession>
    <name>A0A654E6Z3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cobA</name>
        <name evidence="8" type="ORF">MARINOS108_11697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="27006" checksum="6991CF1BFBE8A97D" modified="2020-04-22" version="1">MSKLLLIGAGPGDPELITLKAIRGLQEADVVLYDALVNKELLKHCRPDCELVYVGKKPGIHQYQQIYINDMIVDNAKRYETVVRLKGGDPFVFGRGHEELEHARAHGIAVEVIPGISSALSVPALSEIPLTKRGVNESFWVITGTTSNLELSGDVHLAAQSSATIVILMGMKQLDQIIDIFRVTRGPAEAIGIIQNGSRPDERSVFGTIATISQKVADSGISSPAIIVIGEVVNLGRATEIKQVLENMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7Q2</accession>
    <name>A0A654E7Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="335" mass="37375" checksum="78522F4C8AABED50" modified="2020-04-22" version="1">MAQYITIKEIATKLGISHTTVSRALNDHPRISKATKEKVQQLAEKLGYRRNVSVQVFTRGESKLIGMIVPDLSIHFFARVVQGAQSTLSRHGYGIIIYDTLESLSQEIQAIQSCLDHRVAGILAAISMETTSFDHFLSLSRHDVPLVFYDRVANFLPVPKVVINDHQAAFDATQFLIQSGRKHIAHITASINLNNSNNRLYGYLDALSANNRDADEQLIHYYQLDPSSIDSFIERALLHQPDLDAIFVFNDYVASHTVNVLHRLGKRVPDDIAVMGFSNEPVATQMTPQLSTVKHAGEKMGQLAAQKIVSILAKQEPLVNEKIVISPELIIREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E864</accession>
    <name>A0A654E864_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_12077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18518" checksum="C6EF97FC6768E2C6" modified="2020-04-22" version="1">MIYIIGGVAGSGKTTVGTLLASKLGVPFYDADDFHVPENIEKMASGIPLSDKDRISWLRKISLNMVRWDQEGGCVLACSALKEFYRNILTPIPTHHVQWIILEGDRNLILRRIRERKGHFFDERILGSQFDIFEKPKYGWFYNVANPVDAIVDEILVRINQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8B1</accession>
    <name>A0A654E8B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845674" evidence="2">
        <location>
            <begin position="21"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="327"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="523"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="873" mass="92258" checksum="873F93B2543A0EE2" modified="2020-04-22" version="1">MRKLLLTVGTVLLMAFTVNAQNQRLCASDEVFERQNANPKTLELRKNVEEHTRNFLAKGGKANQRTGILNIPVIVHVIYNTSQQNISDAQIQSQIDVLTEDFRKMNADVSLTPSEFAPLASDIEIEFSLAQITRKSSSKTSWGTNDAMKSSAQGGVDVVSPDEYLNIWVCNIGGGILGYAQFPGGPSSTDGVVISPQYFGSIDRQGAGENFYLSSPFDLGRTATHEVGHYLNLRHIWGDGNCNADDFVTDTPTAGGANYGCPSYPSKSCNNNGGYTSDMFMNYMDYVDDACMYMFSAGQKARMDAIFEPGGSRETLGTSTGGCTLAAPSGLSSSNIGDNSFTLSWSSVSGATGYDVSVDGTVTSTSGTSTTITGLTPGTTYTTKVRSKCAIGSGAYSANLMVTTTGSNCSTGPVTLSLTLDNYPSETSWTLSKDGSTVASGSGYSTSGQTVTEVFDFGSGSYSFTINDSYGDGICCSYGNGSYSLTDANSTVIVSGGNFSSSENTSYCVEGGGPAPDTQAPTAPGSLSASNETQTSVDLSWSASSDNVGVTGYDVFVDGSLDGSTTGTSYSVTGLSSATTYSLSVKAKDAAGNMSASSTVSATTLSSGGGGSNVLLTSYFESGWDGWSDGGSDVARYSGTRSYEGSYSIRLRDNSGAASAMTSGAMNVSAYDQISVEFYFYAYSMENGEDFWVRYYNGSSWSTVATYARGTNFDNNTFYVATVTIDASNYAFPSNAQIRFQCDASGNNDQIYIDAVTVTGISGGAKSAGNSITALDMERRVVEADNGIDIDGFNMYPNPTVDRISLMVDVDEDAEVHMVIHDVQGRVILKKAWNGLEGVTKLDVDVSSLEKGLYFVRVSDGNGLNDIQKLIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9U2</accession>
    <name>A0A654E9U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="97" mass="10957" checksum="7592BD4E6D1D3A6F" modified="2020-04-22" version="1">MNIIVAIHCYIYIMSKSARRKTLSYIEETPKHHGQLVKVIVRGVRKGIASAKEAGHYITYARGSEIVREFPNGRIEVIGRLNNTPVTIDQDAKLTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA09</accession>
    <name>A0A654EA09_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="5">FBPase class 1</shortName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">fbp</name>
        <name evidence="9" type="ORF">MARINOS108_120311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="8">
        <location>
            <begin position="223"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="352" mass="39065" checksum="9316CE1482A7CE51" modified="2020-04-22" version="1">MNKKAYFCQIAQNELYQKMNKNSLGLPIGTTLDRFIKKKQDEFEFATGELSQLLRDIALAGKIINREVNKSGLLDITGAYGSKNVQGEDQQKLDVIANIRFIRALRNGGQVCAVVSEEDEEIVHLNPHCRYIVAIDPLDGSSNIDVNVSIGTIFSIYRRTSPIGGPVTEKDILQPGTEQVAAGYILYGSSTMLVYTTGHGVNGFTLEPSLGEFVLSHTNMTCPEDGEIYSINEGSFHQFDKSIQDYTNWCKDQGMTARYIGSLVADYHRNMLKGGVYLYPNTKKAREGKLRLLYECNALAFIAEQAGGMATNGSKRILEIAPTTFHQRTPFYIGSKNMVEKVVEFVAEKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA31</accession>
    <name>A0A654EA31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045749">
        <property type="entry name" value="DUF6090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19578">
        <property type="entry name" value="DUF6090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="242" mass="28088" checksum="EA234B3F4F2128DD" modified="2020-04-22" version="1">MGDLSTDKTGSKVKSYLLYAIGEIILVIVGILVAIQIDGLNEARKERDREIHYLSNIKQDLVNNIAHMEAFLTQRKACIISAQNVVAHLEGKPIDDWYAFNEDCIRIYDWRRFYQINYTFEELMYSGNLTIISNDSIKSLLLNLESLYKQTKAEEDHFRFDSEEIIYKPIYSIMDLHPTLKMHIGQDVELSRENYGTFFVDTRVKNGFLMAILELSKMNGQLEEMTQITEDLLSIINREIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAM0</accession>
    <name>A0A654EAM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsG</name>
        <name evidence="10" type="ORF">MARINOS108_120501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="17652" checksum="BB49519C6F06CB48" modified="2020-04-22" version="1">MRKAKPKKRYILPDPIYQDTLVTKFVNNLMLSGKKSIAYSIFYDAIKLVESKTKENGIETWKTALNNVCPGVEVKSRRVGGATFQVPIEVRPERKLSLGIKWMIKYARLRGEKTMMERLAGEIIAASKGEGASIKKKDDTHRMAEANKAFSHFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAY0</accession>
    <name>A0A654EAY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AhpC/TSA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024905558" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="17699" checksum="FBAE2013F837CD85" modified="2020-04-22" version="1">MKKILILFCTLFIGVASAQEIRPIKLPELEQLINTNTGNLKVFNFWASWCGPCVKELGYFNALGTQGDTQVILVSLDFPEDIEKARRILEKKEVGLSTYLLDEKDYDKYITSIDNSWSGAIPATLFIDKKGNRYFYESSFEKQELDNVVNKLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED07</accession>
    <name>A0A654ED07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-barrel assembly machine subunit BamA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="POTRA" evidence="3">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="3">
        <location>
            <begin position="420"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="880" mass="99154" checksum="7BBEEEA55552BE76" modified="2020-04-22" version="1">MQKYLLILAVLISYGVDGQIRFGQKSSPASDGVAINYSSPREYEIADIRVQGVQFLDNNALISLSGLRVGDKIKIPGDEISAAIKKLWKQGIIGNVSIEAEKIEGDKIWLIITLSERPRLTKYEFKGANKSQIAELKDKVDLVRGKILTDVVIKNTELSVKRYFEGKGYLNAEVKIKQQKDTLLANSVNIVIIVEKNQKVKVKNINFYGDDNFTAAKLRSKLKNTGEKPRIGLPVDLIEKTLMVLKPKNLFYFLTHKKETSTRELKEYLGEQVNVNVFKSAKFVRSEFEEDKKGLITFYNSKGYRDAEIVTDSVYSIDRKYLNVDININPGNKYRFRDIIWSGNYIYDDAFLDRVLGIEKGDVYDLELVNKKLNYNPTGADISSLYMDDGYLFFRVNPVEVSVSQDSIDLEMRLYEGPQATINEVTISGNDKTNDHVVLREIRTLPGEKFSRSELIRTQRELSQLGYFDPEQVNPVPKPNPADETVDIEWQLVERPNDQVELSGGWGGTFGFVGTLGLSFNNFSVKNIPHLDKWRPLPMGDGQKLSVRMQANGRRYQSYSMSFNEPWLGGRKPNNFGVNFSHSAQRSLNLSNETIGKLQVSGATVSLGRRVTWPDDYFTVSNSFSYQKYTLQGSLTSFYGFSGDSHSLTFNNTLARNSVDNPMYPRTGSSLSLSASFTPPYSLWSKLDYENASSQDLYNLLEYHKWNLDFKYYLKLAGNLVLAPRAHFGMLGSYTDKVGVGPFERFQLGGDGLTGQNFLLGTDVIGLRGYENNVITPTDANGTKGGTMFTKFVMELRYPISLNPSATIYVLTFFEGGNNWNNLDNFNPYNLYRSAGLGVRIFMPAFGLLGLDWGYGLDPAPGSLEVSGPQFHFSIGQQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDI8</accession>
    <name>A0A654EDI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YicC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="206"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="33172" checksum="A3727DF8C4E5F7ED" modified="2020-04-22" version="1">MLYSMTGFGSAEAESKMYRVKVEIKTLNSKFLDLAPKLPRELADKELEIKNLMTQHLKRGKVNLTIELIPVNLEEPAVHINQQLFKSYYRQYEQLAAEVGANPKDLFRLALHSPDVIVPDGGNNEVDWEMVQGALMEALEKCNQFRAAEGKSLQEKLSSYLDGIANGLAEVTEHDPQRISQIRERISSSIEDIKEKTQVDQNRFEQELIYYIEKLDITEEKVRLGRHLEYFREVMESGDSQGKKLGFISQEIGREINTIGAKANDAVIQRAVVQMKDELEKIKEQSMNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFS5</accession>
    <name>A0A654EFS5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tgt</name>
        <name evidence="6" type="ORF">MARINOS108_90161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="13"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="376" mass="42440" checksum="AC79CD3098FE2E65" modified="2020-04-22" version="1">MKFTLQHTDQKTKARTGLLETDHGPIETPIFMPVGTAGTVKAVHQRELKEDINAQIILGNTYHLYLRPGLEVIQKAGGLHGFNGWDRPILTDSGGYQVYSLGDNRKITESGVRFKSHIDGSMHDFTPERVMDIQRVIGADIIMAFDECTPYPCDKKYAEDSMHMTHRWLKRCIQQFDTTDPLYGYSQTLFPIVQGSTYPDLRKQSAEFIAEQGREGNAIGGLSVGEPHEDMYAMTELVCDILPADKPRYLMGVGTPENILECIALGVDMFDCVMPTRNARNGMLFTSEGIINIKNEKWKEAYIPIDPALGGYVSTFYTRAYLRHLIMSKEILGAQICSIHNLSFYLWLVKEARVQIKAGNFDAWKTAMVKKVTTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSM9</accession>
    <name>A0A654DSM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="16283" checksum="C3D1048FBC08CFBB" modified="2020-04-22" version="1">MNIKNLNQAFVEIAEKKNQLFQFAKEGSTYQELQDEVRRLEEDFQMTFGAYIEEALFNVHDEYCPDNEVLKPISYLASHYEPKNGNEVYDVDPEEGIEVEADDFPGIKAKLVLVPGPTRLVLQGLNADFKETVWVARQPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSW9</accession>
    <name>A0A654DSW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="94"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="389"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="769"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="863" mass="97640" checksum="589ED1E79F986BCC" modified="2020-04-22" version="1">MNQATSPPKLADRFLKWYCHEDLLDEIQGDLYEQFHKNLKTKGLTTAKRKFTLDVIRFFRPSSFKSTQLSMNTQIIANYIKVAFRVFKKEKAYTFTNVFGLALGITCSLFIYLWVNDELKYNQWPAHVDDIHYVLVNQIESSGTIHTWRTTPQPLREVLQDKYPAIEKAAITNWGATLILKKGREHVTLSGHYGSPELFEIFSIPFIQGDHQLLYKQPESIVINESSAARYFGDDWRSKNLIGQSITDKNNRTFTLAGIFENIPKHSTLKFDFIIPFDYYVLINPSQKHWGNYNHNMYVKLAPGYSTASANDNILNAISENRPDQEETAPLILQPFSSLYLYNKYEQGQLSGGRIDYVRLLSISAILILILAGVNFMNLTTAKSAKRSRETGIRKVMGAVKSSLRAQFLTEAILITLLAFILSAFFTMGLLPYFNVLAGKEIGADFFTPSFILASLGLILSIGFISGLYPAIYMASLHPILSLKGIMRADRSNALFRKGLVVFQFVITIVMIFGSITIYKQLQYVFSKNLGLDRENVIKMGFGDLNPQTFEIYKERLLQMPGIKAVAASDGDPTNIGSSTSDPYWTGRDEHTDVYFNILGVNPDFIPLMSIQLKEGRNFDRNIASDSNNYLINEVSANIMGFDNPIGQDLEFWGQKGKIIGVTKNFHIQSLHAPYKPLIIRMDPEPSLMLIKTKSNMTQEAIASMETLHKEFQPDRTFDFTFMDKAYNERYKSELLVSQLTLYFTIVAIVISCLGLLSLVSFNTEVKTKEIGIRKVMGASTASILSLIGKEFLMLVFIAIALASPLAYFIMQDWLNQFAFRIDLDLSLFLMAGMSGLLLTILTIGHHTLQAALRNPADSLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSY9</accession>
    <name>A0A654DSY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sulfate transporter YbaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybaR</name>
        <name evidence="3" type="ORF">MARINOS108_10185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="408"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="509" mass="54756" checksum="FDA69727EFBF8D7C" modified="2020-04-22" version="1">MKKYFNLFDLSQKVNYRTEILSGLTVALALVPEAVAFALIAGLSPLTGLYAAFVMGLITSILGGRPGMISGATGAVAVVIVALVQSHGVEYVFATVILAGLIQVTAGVLRLGKLMRLVPHPVIFGFVNGLAVIIFMSQLDSFKDSSGNWFGGEQLYMMLGLVLLTMVIIWGLPKLSKALPASLVAILSVFGIVVAFGVDTKTVGDIASISGGFPPFHLPAVPFTWETLVVIFPYAAIVAGVGLIESLLTLNIVDEITDTRGRGNKEAVAQGTANILSGVFSGMGGCAMIGQSLINISNGARARLSGIVASVLLLVFIMFGAGLIEQLPIAALTGLMIMVSIGTFEWASLRTFNKMPKSDIFVMVMVTLVTVFLHNLALAVIVGVIISALVFAWDNAKRIRARKSIDENGVKHYEIYGPLFFGSVIAFNEKFDIQNDPDEVIIDFQESRVVDMSAIEALNKLTERYLKVGKKVHLKHLSPDCRQLLQNADDLIDVNVMEDPTYKVALDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT64</accession>
    <name>A0A654DT64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="268"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="373"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="469" mass="51199" checksum="BF91F150E53971B8" modified="2020-04-22" version="1">MKVEQIYTGCLAQGAYYIESNGEAAIIDPLRESEPYILKAEKEGAKIKYIFETHFHADFVSGHVDLAAKTGATIVYGPNAKTEYDIHEATDGELFRIGKIKIKVLHTPGHTMESTTYLLIDEAGKEHAIFSGDTLFIGDVGRPDLAQKGTLTQDDLAGYLYDSLRTKIMTLPDEVIVYPAHGAGSACGKNMSKETTDLLGNQKKTNYALRADMTKEEFIKEVTDGLLPPPQYFAQNVAMNKSGAKGMDEILEKGNVPLDVETFEAVANHEGALVLDTRSPGEFAADHVPNSIFIGIDGSFAPWVGALIPDLEQPIVFIAPEGREEEIVTRLSRVGYDNTLGYLSGGMAAWKAAGKDTEQVTTIPAHQFASAYKEGGLNVMDVRKPSEFEAEHVEDAMNLPLDFISENMDQVDKKKQYHIHCAGGYRSMIAASILKSRGFDNIVDVAGGFKAISETDIPTTNYVCPSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTD8</accession>
    <name>A0A654DTD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="8047" checksum="1144BE89BC7B237D" modified="2020-04-22" version="1">MKGLSYSSLRAGKRYWLVNYGDRYEFEILEVLSPQDFKLKDVNTLELYLMSEITRYGKGDDFEIRDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTP4</accession>
    <name>A0A654DTP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="32803" checksum="54E63286129783F7" modified="2020-04-22" version="1">MPIRYWNVKPSETTQNYVRFYWFLESDESYTHHSMADVCPELVFHYHGRFNEILANGQQERSFLAGINAPSSQTRQFSIDQAFGMFGVYLYPHAIPLLFDIQASDLTNQMVDIDILTRKYGSDLEERIMLSKSHEERVSIMETFITQRLQQQKETSLPVFKALQFIMKSEATPTVKDLTQDYFISERQLERQFQRFTGFSPKQFIRIARFQNTMQFYGSQELRLTDVALNCGYYDQSHFINDFKQFSGLNPKEYFKGKTTATLWRDSKTHFKDQAIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS5</accession>
    <name>A0A654DTS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="5">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="111"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="3">
        <location>
            <begin position="456"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="592" mass="65192" checksum="E051DC5205D278E4" modified="2020-04-22" version="1">MKNINRSTVIIAISTLAIGLILGWLIFGGTDKTSENEHIHNAGETKETIWTCSMHPQIRKNEPGDCPICGMDLIPLESETNEVDPMAVSMSPIAMQLAQVQTMKVGRDNTNKSLRLTGKVQADERLLYTQSSHIPGRVEKLTVNFTGDFVKEGQIIAYFYSPDLVTAQEELFEAKKIKETQPALFNAAKEKLKNWKLTDKQIDQILASEKTIELFPILANVSGYVTQKRVNLGDYVKQGEALYEIADLSKVWVLFDVYESDMSWINKGDAVSYTIQSLPGKTFNGAISYIDPVIDPKTRVAKARIETANKELLLKPEMFASGTIESKTNTSNTSLTVPKTAVMWTGKRSVVYVMQTSAQGIGFLMREVTLGPELGESYVIESGLQSGEEIAINGTFSIDAAAQLAGKPSMMNPEGGVAMTGHNHGGNQNTTMTNMPVNSKKTAISDEAKKSLVPLFDSYFKMKNALVNDDFEKAKVAGNEINSSLSKVNMNLFKGDAHTLWMQQSSVLKQSAQHLEHLSDIKALRASFIKVSKSMIAIAESFVPITTPVYLQHCPMADSNKGADWLSNKEEILNPYFGQAMLSCGENTKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL2</accession>
    <name>A0A654DUL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14865" checksum="051118D205526825" modified="2020-04-22" version="1">MTTYLFAYGFLKTRFHGNRKTETPEIKAELITNGFYPGKMFRVNVYPGVVYDPECGQKVKGEIFKLENAEEMLHVLDRYENALPLVLLDPDYERRMRTIETPSGPLDCWVYEYLKAVNPATEIKSGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM5</accession>
    <name>A0A654DUM5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="41"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="549" mass="61629" checksum="BE6079A759202FFA" modified="2020-04-22" version="1">MYKALFILLIALAGLGCSEKPTSEAVEQPPVFKWENATIYFLLTDRFYNGNPENDTNYGRKPDGAVLRSFMGGDLQGITMKIEEGYFDDLGVDAIWFNPPVEQIHGYVDEGTGKTYGYHGYWARDWTAIDPNFGTMEDLKSLVKVAHEHGIRILMDVVVNHTGPVSPEDSQWPDAWVRTSPQCTYTDAASTIACTLVENLPDILTDSDEEVALPDFLIEKWTQEGRLEEEVAELDAFFEKTGYPRAPRFYIMKWLTDYVREMGIDGYRVDTAKHTEASIWGELYKLASEAFKDWKSTSPAEVLDDEDFFMVGEVYGYGIQNGQNYFYNAEDSVNFFENGFKSLINFSMKGDAGRVPEEVFSYYANQLSTVLSGYTVLNYVSSHDDGGPFDRERTNGYLAGTMLMLTPGQAQIYYGDETSRPLQAEGAQGDANLRTMMNWADLDTPEVQGLLSHWQRLGQFRKDHVAVGAGKHQLMNETPYTFSRTYSDAATGDRVIVVMDNDGSAVNSEGIFEDGERVTNYYTGETTDVANGEISFEEGVGLLLIGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ7</accession>
    <name>A0A654DUQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="105" mass="12374" checksum="B9FBAB13B8160199" modified="2020-04-22" version="1">MVLNLIVLVIFRLDDFCSLMFQVLSFYQARMIQPHRRHFVPRLPQAPDTKAYGIEIEENCQRTNKDEISYEVCVKATHINTLITWENVRSSIVLQLKAPGLRFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV28</accession>
    <name>A0A654DV28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="FeoA" evidence="3">
        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FeoA" evidence="3">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="38449" checksum="4F811D3724451317" modified="2020-04-22" version="1">MTPNPILALIVFFAGGALIYLGWKYKLWARVFHDSERDRKTAMEDVLKQLYHVEYSGRKATLNAMAGALKLSDKKLVSLIEEMSALNLIRAQADTISLTRAGKDYALHIIRVHRLWEKYLSERTGIDKSEWHNRAEQMEHTMTSEEAEELYHELGSPRFDPHGDPIPMKTGEIIESNAIPLSGIRENALVKIVHIEDEPEVIYEQIIDKKLHMGQQLKVTEIDDHRVRFFSEGQEYELSSIVASNIGVRKLSEEEVFESGKVRLSSLRQGEKGQVIGISSECRGANRRRLLDLGFIKGTSIETGLEGPMKEPKAYLIRNTLIALRNDQADLILIEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV42</accession>
    <name>A0A654DV42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="29327" checksum="350B6AD33DDB1C82" modified="2020-04-22" version="1">MASPFFTFKEYLKYRSVSLNAHDLHSPFVFELYNEVIRKRAKTQESALRKLRQKITRSDLTVDFQDPKTGEDHRSTVKKLSRRVASSHSFSYFLFKLINHQKYHTVLEAGTSIGLNTLYMSQSVASSVWTLEGSPQIANIAKRHFEKLGLSDIHQVIGDVRDTFVSTLSESQPALIFLDADHRSDTIAFYLDAIRKHSPGTQCIIVHDIYWSQDMKNSWSAIVKNPAYPLTIDIFQAGIIFPHHPIKKQHFVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV81</accession>
    <name>A0A654DV81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="152" mass="16844" checksum="09411F901574F077" modified="2020-04-22" version="1">MLAGCYLSSPHRIMIEQQIQELHDAGLELNKLKTSFFNKITAFSIGLTGLLIGLKPASISVYNAKIAFLTSIICLALCALFSLLAQHYEINFSKQKEAIIRKGIESNTQGIGWINKPLIYKAAESLTYICLTISILTLIAYVYLLEFTNGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV95</accession>
    <name>A0A654DV95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="21096" checksum="21A9D665D2C4BB56" modified="2020-04-22" version="1">MEDSFIISKIQDPETINYGFNLLVKAYQERVYWHVRKMVIDHDDADDLTQNVFIKIWKSLGNFREESRLYTWIYRIATNECLNFLKKKKRKFMIPIHDVAGELSHKIDQGAYISGDEIQLKLQKAILTLPDKQRLVFNMRYFDELKFDDIAEITGTSVGALKASYHLAAKKIEFFLTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF1</accession>
    <name>A0A654DVF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">hisS</name>
        <name evidence="10" type="ORF">MARINOS108_10337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD10968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="51296" checksum="ADF60F183F4404C9" modified="2020-04-22" version="1">MATSKPSIPKGTRDFGPLQSARRSYIIEIIKKNFGKYGFNQIETPAMEQLSVLTGKYGDEGDQLLFKILNSGDYLKKTSVEDYTKGSPHMLNQISEKGLRYDLTVPFARFVVQNQHDITFPFKRFQIQPVWRADRPQKGRYREFYQCDADIVGSDSLWNEAELTLLIHDVYKELKYDGFVLKINHRELLNELARYVGLAGKEMPFCITIDKLDKIGSDKVQDELLALGANGTKLRSVIDLFEQSADNTTKIELFKKLIGENKGTTELLAYFDYLTRTGTKNLKIELDLSLARGLTYYTGIIFEVKATDVQIGSITGGGRYDNLTGVFGLQGISGVGISFGLDRIYDVLEEKNLFPESLTKSADVLIAHFDQECFLHGIGLLNQLRSAGIRAEIFPDAAKIKKQFNYADKNAIPYVLVVGTEEIDKKEYTFKNMRDGNQEMLSIESVVARLESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS8</accession>
    <name>A0A654DVS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019223">
        <property type="entry name" value="DUF2147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09917">
        <property type="entry name" value="DUF2147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025000087" description="DUF2147 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2147" evidence="2">
        <location>
            <begin position="23"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="143" mass="16390" checksum="71599AD3C9BE5689" modified="2020-04-22" version="1">MRQIFILPLFFSLISVQAQSVTGLWKTIDDETGKPRSIVQIEERDGQIFGTIVRLFRSPDEEQDPVCKVCPGKRKNQKIIGMEIISGLSYDQDDEEYGGGEILDPESGNVYDCKIWLSEDGTLKVRGYVMFLYRTQTWLPYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU0</accession>
    <name>A0A654DVU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="564"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="985" mass="109068" checksum="C9BF67AC715BC36C" modified="2020-04-22" version="1">MTISRIKFYLSFLLLCLIGMHAYGQVTIAGQVTDERTGESLIGVNVLVKGTVLGTITDVQGNFNLKITSPPPVTLVISFVGFERQEIEIDQAVISNLQVKMTESFMLGQEVVVSASRVEESILQSPVSIEKMDILAVQNTSSDTYYKAIANLKGVDVASSSINFQIINARGFGNTGNTRFVQLIDGMDTQAPALNFPIGNLNGPSELDVESVELIPGASSALYGPSAFNGVLLINSKNAFDYQGASAFVKTGVNHVGSSADQGPALMKEASIRYAKAFNNKFAFKINGSYSKADDWHGTDAADRNADFNPLASVGGENPGADRLHFHGDEAGINLAIFPFSAAFGTIARTTQFENGRFASNYMNAGDLPNHVATITPYKEVDLINYGAENMKVNTGLYYRITDNMELSYLYNAGFGTSIYTGAQRYSLSNFGIQQHRLQLRGDNFFLRAYGTFENSGDSYITEFLAKRVNDLMVGYNFGDYHNGFNPFENQGKGDLTGYLVDYGIEYLRSISDQGYQPGEIAALSEAERLQVQQNAHQYARSTVDDRYIMDPKTGTVVDGEGNTLTFEDVKKEALKGTIPNGPSFADKSAMYHAEGQYDFKNEIDFMELQMGASFRIYDLGSKGTIFPDTVGNEIAIKEYGVYAQAGKRLTDNFKLSGSIRYDKNENFKGQVNPRISGVFTFNKTHNIRASVQTGFRFPTTQGQYINLDVLSSRLLGGLPQFYEQYLPDPENNYYYSGASVNAFRNNIFSGQEISEAATALVRRTDFSPVKPEQVKSIEVGYKSLIQNKLLVDMVYYYNSYSDFITQELVVKAQKDTDDEPNYLTILRSNADNAFSIYTNLDNQVTTHGAAVGLTYNLVKGYQIGGNYTWSKFISGYDENVLNDFNTPEHKFNVNFGNRKVTDVFGFNVTYRWQEAFRWESSFARGPVPAYGTLDAQISLKLDNLRSILKIGGSNVLNNYYIQSLGGPNIGSIYYVSISFDELMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ9</accession>
    <name>A0A654DVZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="573" mass="65494" checksum="F78B627417901A1A" modified="2020-04-22" version="1">MNNSKDRNYLPKNYQELLAKYRKVPPVVLETNHPASPKRSALATGLEVYSGEWGDVQKLHLLRRTLFGTRQKDLEALAGLDVSQAVDLLLTKGTVTLPVNNYNDPANGVEDPEIAFGETWINSAYGDQYEGPRTNSLKGWLIKNMLNQDTSVEEKMLLFWHNLLPIQTWGVFYAKLSYRYFEMLRRNLFGNFKTMIKELTLDPAMLLYLNGTFNNKEAPDENYGRELQELFCIGKGPNANFTEEDVQAAARVLTGWVVRWEDFEASGILPSYFYSPFHDTTNKQFSAFYGNRVILGRTGEAGAEELDELLDMIFDNNETALYLCRRLYQFFVYPEIDAAAEGQVIEPLANILRTNDYEVKPVLEALFKSAHFHDEANWGAIIKSPTEYVLGLWRTLEVEGVDTEDLLLGYTQHNSFLWNMANLGMEIGDPPSVSGWPAYYQTPSYDKYWLTTDTIANRAIASDSLVYWGFWIKEGVQIPADLIKFISGLNHPEDPNLMLLESSRLLLGMELDTEMLNNLKSILLSGQQTDSYWSTAWGELTENPDDEEYRMVVENRLKPTFQHLLQLGEAQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW60</accession>
    <name>A0A654DW60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">surE</name>
        <name evidence="7" type="ORF">MARINOS108_10960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="28287" checksum="F37BFF5B41346341" modified="2020-04-22" version="1">MSKPLILVSNDDGITSNGIKKLVSLMAQIGDVLVVAPDSPQSGMGHAITVGDTLRLTENRLFGDQIPAYECSGTPADCVKLAKHHLLKDRKPDLVVSGINHGSNTSISVLYSGTMSAAIEAAIEGTPAIGFSLCDYDTDAEMNHVDEYILKIAREALTKGIPKGIALNVNIPAHQNQKIRGIKVCRQANARWEEEFDQRVDPHGRKYFWMIGNFVNHDKGEDNDEWAIANNYISLVPCQFDLTGHHAIRLLNDEWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW69</accession>
    <name>A0A654DW69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="27605" checksum="AFE814AD694086C1" modified="2020-04-22" version="1">MDLKVDHSSPVPLHLQVEKLLRDLIDHPNYTNGAFLPKEVELSKLLGVSRNTVRQATNKLEYEGLIFRKKGVGTKVAKREISTNLGEWHSFTQEMSSKGIPFRNLELEVEWVVVSERISNFLNVDPGFKVLKLSRLKGTEEPLVYFESYFQPRIGLTGNEDFSKPLYDILERDYHSIPAISKENIKAGLAGSKAKKLKIGENDPILIRERYVSDPGNRPLEYNIGYYRSDMFTYTIEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE0</accession>
    <name>A0A654DWE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="102"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="34894" checksum="303D59C31D0A0968" modified="2020-04-22" version="1">MVYDMISCGQFGQQLAELVNSSYRHIARCVYKESLVQEDLQGKNAIAGFYQFDKLDLSEIKWIHAFGAGVDDYLKQPTIQRDLILTRTLGYMDKRIGEYCLAYLLEDLKWVVSTHDNQRSHLWDRTNLNVLYNKKVLVLGTGFVGQGIASALGHLVEKIDGINGSGTSNPLFHQTMAMGNISQAHLEHYDIVISALPLTPSTRNFLNQAFFRLLHGAFFMNVGRGKSLVEDDLLWALENGHVRKAVLDVYQIEPLPSDSPLWDHSGVMMTPHHSGLTTFEDIRKSFEESVKAMKGGIRNQLFVNINQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ5</accession>
    <name>A0A654DWQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospho-acceptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="371"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="248"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="406"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="633" mass="72080" checksum="11492DA07FB6257C" modified="2020-04-22" version="1">MLKKDLYAVLYAITALVVAGTVAYYIFVVQKDVITNFNEDPTIVRVASKQSAMGQQIVKTAVGMGYSSTERNFSIFQSELGRILPEWRKGHKALVSGDPELGFAVPSTSSDYLALQEDLKFFYEQMDINASNLMDIVYTTDEKDINYLALRSSIETLINTVRKYQIATDKIADYFVQEAQSYKTGFSLVEKIVFAAFLGILLLQGLFVFRPLVKLAGDNYLSANKAYVKVKKSEEELKINFKKQKLINKKLYESRKEIELNNQKLKESESKLLKSSEEQIRINEKLIKAQDELNQAYKRLQDSEVEIRELADKQLQDNEKLFLAEKKLKETLKKEQKSKEELNMAIQSLKDAQSQLVHSEKMASLGQLTAGIAHEINNPINFISSGMVSIKMSIESMREIAEEYSRLDEGADLEEVIENVKELKEEHEYEEILEELDELIKDVNYGVTRTIEIVKGLRVFSRLDEEESKTANVNENIDATLTLLRNKTKNTIKVSKYYDEKMKDIECYPGQLNQVFMNILNNGIQAIPKERKDGEITIYTEELDNEVVVRIKDNGVGIPEKIKNRIWEPFFTTKAVGVGTGLGMSITYGIIEKHNGKIELTSEEGKGTEFVITLPKKIQKVTKDQSTKVAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR0</accession>
    <name>A0A654DWR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding motility-associated C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="789" mass="82919" checksum="07C82F30F84BBB1F" modified="2020-04-22" version="1">MTATVTDAAGNSTSDATDGELTIILEGVDTDGDGILDEDEDTDGDGDLANDDCDADGTPNYLDADPCDTDGDGLDDSEEDTDGDGNPYNDDCDEDGTPNFQDADTCDDGTDTDGDGVTDVEEDIDGDGDSTNDDSDGDGTPDYLDTDDDGDGILTEDEDTDGDGDPTNDDCDADGTPNYLDADPCDTDGDGLDDSEEDTDGDGNPYNDDCDQDGTPNFQDADTCDDGTDTDGDGVTDVEEDIDGDGDPTNDDSDGDGTPDYLDTDDDGDGVLTEDEDTDGDGDLANDDCDADGTPNYLDADPCDTDGDGLDDSEEDTDGDGNPYNDDCDQDGTPNFQDADTCDDGTDTDGDGVTDVEEDIDGDGDPTNDDSDGDGTPDYLDTDDDGDGVLTLDEDTDGDGDPTDDDCDADGTPNYLDADPCDTDGDGLNDEEEDTNGDGNPYNDDCDEDGTPNFQDSDSCDTDGDGILDEDEDLDGDGDPTNDDCDADGTPNYLDADPCDTDGDGLNDEEEDTDGDGNPYNDDCDADGTPNFQDVDSCDSDGDGILDEDEDLDGDGDPTNDDCDADGTPNYLDADPCDSDGDGLNDAAEDTDGDGNPYNDDCDADGTPNFLDSDSCDTDGDGVLDSDEDVNGDGDPTNDDTDGDGIPDFLDTDDDGDGIDTKDEDGDRDGDPTNDDCDGDGTPNYLDTDRCPKVEPRRGFTPDGDGINDFFYIKDIENYPNNTVQIFNRWGNKVFEIKGYDNQNNVWKSDVNSGLRIGSDNNVPSGTYYYLIQLGDGSDPISGFVVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX25</accession>
    <name>A0A654DX25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="31255" checksum="0DC8F17F30E64E59" modified="2020-04-22" version="1">MTIDVQIVNAFTEAEAGGNPAGVVFNADQLTSAQKLAIAAQVGLSETAFVSASEIADFKLDFFTPNRQIAHCGHATVGTFSYLRQAGLIQGANSSKETIDGRREIHLKGDQAYMEQLAPVYRPADHCENEILQALGLRKSDLIPGAPLEVVNTGNNFLIIPIKDAKTMAAIVPNMAKITELSEAFDLIGFYPFTLDTGTEERIADTRMFGPRYQIYEEAGTGMAAGPLACYLYDVLEIKQEDFLIRQGRFMASPSPSLIEVHLNIQNGAIASLLAGGKGKVSQQLTIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX57</accession>
    <name>A0A654DX57_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">dnaG</name>
        <name evidence="15" type="ORF">MARINOS108_10963</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="260"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="645" mass="73374" checksum="63B357B40B1689AC" modified="2020-04-22" version="1">MISPATIDEIKNRMDIVDVVGDYLTLKRSGSSYKALSPFTNEKTASFYVVPSKGIFKDFSSGKGGDCITFVMEVDGLSYLEALKYLAKKYGVEIIEEEQSDEAQEAQNKRDSLYILLNFAKESFQELLWESEEGKSIGLSYFKERGFTDESIKDFELGYTLSEWDHLLKAATAKGYRQELLEEAGLIVVKEEGKVYDRFRNRVIFPIHNVSGKVVAFGARMLGKDKKQPKYINSPETELYNKSRILYGLFQAKQDIRKEDNVYLVEGYTDVISMHQTGIKNVVSSSGTALTEEQIKLLKRYTENVTVIFDGDAAGIKASIRGIDMLLEGGLNVRAVALPEGEDPDSYAKQLGTSAFSHYIESESQDIIRFKTKLFLADAKDDPVKKAGLIKDIVRSITKIDDPVKRTVYLKECSDLLGISEAVLVAEQNKILIQQNRDKGKAGYQPGENLTPQDLLVAQPEEPEELDIMKVIELQEKESIRVLVNYGKSHITNHELVDEDLISYFLSEIEEIQFTNPVYKSILDIFKEKLLEGVIIDGDYLIQHGSEEIKREVVNLMTSKHEVSENWEKKFQIYIPKEEEQLKDVTYSNILRLKFRIVQHLIEEENRKLKETTNEDDIDILLDEINGLKKIEMSLAEFLGNVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX63</accession>
    <name>A0A654DX63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="655" mass="72040" checksum="EED2D94ECAA00F62" modified="2020-04-22" version="1">MKNLTNIFSLALAVMLSIVGCQMDEPELDSLISSSSLKYEVTQNPDDPNMVILESLTPGAIPMWVTPMGRSTKVKDTVRLPFSGSYQFIYNISASGGFVAGDTTTLEITTMNLSYVDDPLWNTLTGGVGESKTWVLDLNEDGLSKYFLGPMYFYGTDNGWQGECLVEGGDCWNWNPDWPGNQWVADVGNYGEMTFSLDGGAFLTANHPMIPARGNESGTFFLDVNNYTLNSTDATALHTPNNEACVEDWGKARVFSLTDDYMQLGFLRKTSCDGAAMLVFNYLSKEYSDNWVPVEEGDPEPPYDGDANGDLTTNTSTSKTWIIDLAYPYNWHDLGGAALNEVATLGTDPEGFAFTTWSPPYDADIFSGVSMQLTKTADAEGEYIIETGAGSFEGNYTVNEKNEIDFGQAITFFSGVGGWLTFGTTADNKLRILMAESTAGAVNGIWLGQKAADKDEYLSIHLKASGGGGATDPEDAIKSILTSTSWKIDSDRTYDVTTTWGAEQGPIIFSDFATWSWNPLPGEHYAAGEADVDYGQMTFMENGTVEILQRRRIYTYEEDGETMVRNGMPQDGDMLSTDEQVTLMGIWVLDLEANKLRISVPVLHPWTGDYAVAKWGDLTIQRVEENVMILKVLRDAELSGEDEFLMAYVYVPDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX79</accession>
    <name>A0A654DX79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024899690" description="Peripla_BP_6 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="619" mass="72035" checksum="52AD08C99C046836" modified="2020-04-22" version="1">MKKYLLLSGMLLVCVFAYAQREQAEYLEAKRLFNNAQYSSAKAAFSALSQSEVFGRHASFYFGLCAFQQEDFAVAKDMWRQVLIQFPTWDQKPEVLFWLAYANFMTGDFSRALEYSTQLTSETLNTEDEERMIATFISPLDLAEVDSLFSEYPDSKPLAEVLVKKLNAATYSERDIQRIDELVTEWGFDINTIAEYELPLVRKEVYNIAVVMPFLYESLQNTSLITQNSLVMDMYQGMLMAAEDLTKRGEPVNIFPYDTKRKASATKKILENKGFENTDLIIGPLYPEPNALVDQYSVANKINKFNPISSNSEVVGDNPFSFLMRPSYETMAMKCAEFAIAENKNPYAMIFYEQSARDSVFAAIYKQQLEEAGFEVVLFREITKDNSRQLLDTLWAQYDQYLTQEEADSIQEIRGRFVKSRRIRRDEMDRMSRNPDFVLPISYDDDQNRIVYYEKLFRIAPDSIGHILAATRSNLFANNLISAVETRGDSIRLYGYGDWLDFTMLSFNQLDRLGVALSDPDYKDRNSFYYRDFQERFIAKYKTRPSVNHLRGYELVYFAGHMMHQYGKYFQTDLRSGVYRKGRIFEGFRYGVANDNQVVPMVRFKDSKLEVVNREMYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL0</accession>
    <name>A0A654DXL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044995">
        <property type="entry name" value="TMT/HOL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="entry name" value="PTHR32183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22131" checksum="534CB99BE69E6A13" modified="2020-04-22" version="1">MQQLDQQYWETRYQNGLTGWDAGAITTPLREYFDQLNDKSVSVLIPGAGNAHEAAYLFELGFSDVHVLDISESALRQFQLRNPLFPKSHIHQGDFWAHEGEYDLIIEQTFFCAIDPVLRAAYVKKTSDLLRSGGKLVGVLWNHPMGENEPPFGGSEAEYIELFSERFEINVLETAYNSIQPRAGREVFIKMTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP4</accession>
    <name>A0A654DXP4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035163">
        <property type="entry name" value="Pom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17251">
        <property type="entry name" value="Pom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024843400" description="Pom domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Pom" evidence="2">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="32651" checksum="CFF60D3D0B019944" modified="2020-04-22" version="1">MKIRLIIFFNLFVAELIAHGQTQLTAGMSYTRQSLTWSIAGNLNGTSPNIFSELKWQRVMGVGALVAYQHPITDRIVAFAEHQHQLLVQGSVTDSDYEGDDRTGRVFFAKEDAGKGYTLASQGGLLYQVCKRKSMTFTLGGGYGLMSQRFFLLNEKMGLRSSYTNQWYGPLLTGRLQLLAESAFGITLKTTYHQVRYHATGNWNLIERFQHPVSFRHRAKGFGLENQLVMSYKMSGGLCVEVRPSYGYWTTGMGIDTVYKKDQSTPKTRLNDVTTEVLGVEVGVVWRLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY8</accession>
    <name>A0A654DXY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="43191" checksum="65494E8C16F5C0B3" modified="2020-04-22" version="1">MKIHIKTLFGLEEILAEEVRKIGGQNVEVQKRSVSCEGDMHFLYSANLNLRTALKVLVPVYNFTARTEQQLYDQVMRHDWSKYLNINQTFAIDNTVFSEFFRHSQYAALKTKDAIVDQFRNRTGKRPSVDIKTPDIQFDLYGFKDQFTISLDSSGDTLNRRGYREPGHEAPLNEVLGAGLLHLAGWNKSIPLIDPMCGTGTILIEAAMMGQNIPPQINRHDFGFKNWSNFHPTVWNQVVSEAKAGIRKAQLNITGGDIDGDAVLMVNKSLRKFKLSDSVTVTRQDVRDHRPKTPDGMIISNPPYGERIGRENTNDFYKSIGDVLKNNFTGFDAWLMSSNMEAFKHIKLRASKKIVLFNGPLECKFQKYEMYRGSKEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ0</accession>
    <name>A0A654DXZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043744">
        <property type="entry name" value="DUF5689"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18942">
        <property type="entry name" value="DUF5689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024821618" evidence="1">
        <location>
            <begin position="21"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5689" evidence="2">
        <location>
            <begin position="379"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="776"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="847" mass="92366" checksum="08038DEA710C606D" modified="2020-04-22" version="1">MMKKYTFLLPFALLSFLAFGQAPSGYYDGTDGLTGEALKKQLHRISSGHKVWAYSDFRDTILPDLDEDPDNPDNIILFYKNASIPKANFASNNEPDYWNREHTWPKSHGFPDLSDTAYTDVHNLRPSDATVNTSKSNKDFNDVENIAANAEGEAPDTYTNADFWDPRDEIKGDVARILFYMDMRYESEALDLELVDHKSFSGDPELGVLFTLLRWHAQDPVDAAEIARHEKAYGYQNNRNPFVDHPEWVGEIWGTASEPFVSLDQSNFSQNFGTVPFGQSLVQQYTVNAYNLEGDLTVTVEAPFYVSSDNSTFSGSSTFTHADGVVSENFTVYLKFEPQQSDGGTYEGMVTHASAGLTSVELNVQGKEGEVTVTTIAKARQQELGSMAYVTGVVIDAGNNSGNSRVIFDGTAGIVVRSFDAGNESANLVQGDSIVVSGGLSDYAGVLQIEQSPITITLVAQGAMLPEPQEVTIAEVGEQYESELVVIRDAAFKDAGGTFAGGGSAGNFEIKDATGTMVFRIGSSEHPLVGTRIPNGLFDITGFVGEFAGDYQISVRDLEDMVLVDEEEEERPPVISIAEARTMVEGSVVTVKGIVIGGENNNRDNRVVFDGTAGLVVRSLDLGNASSVLVMGDSVMITGGIFDYNGLFEIEESPVYIDILNSGNALPEPQEITLSAVGEEYESELISLRNVSFVETGEFAVGNYTLTGDDAEVVFRVGTIDHPLVGTSIPQVSVDLIGYVGQSNEDYQVFVRVAEDLTFLEEVLGVKDARPSLNLVYPNPVSGLLHLHLPEGIDYPVNLSLFDLQGKKVKTAQVTEGTLSVEELQSGMYLLTLDKEGRIFYNRIIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ3</accession>
    <name>A0A654DXZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two component regulator with propeller domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="811"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="865"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1393" mass="158427" checksum="24000F319D65C58F" modified="2020-04-22" version="1">MMNIKLKNTLIEYRRVFFVISLLLVGGLGFGQENHRFRHLSTADGLSQGSVIAIAQDQKGLLWFATRDGLNTYDGNQFTVFRNDPKDSTTISNNDVLEILTDQYGDLWVGTYNGLNRYSYSQGRFYRFYNDKNDPTSLANNSVWAIHEMDNGEIWVGTGGGLTIYKDGKSFRVQHDPADDKSLSGNYVVEIFQDSRDDIWIGTSKGLNRVSAREGNKIYFDRYLSDPGQQGTLSDNFVQSIAEGLDGTLWFGTRGGLHRLEEQDRFVAFHHDPADPASISNDDVRSLTFDEEGNLWIGTYRGLNKMSTPGIFLPILNDPNDAQSLSKNTIKSTFIDKKGSLWVGVYYGGINMLDETNSNFRNYQQLPAGNGLSYDVVSSIVEDQFGKIFIGTEGGGINFLNPKNGKISHLKATGKPAALSSNNIKALYLESGKNLWIGTLNTGIDVFDTESGTFKAHFDKDLGLSHNSVYAILKENDSLFWVGTFGGGLHLLNTHSKTSENILYDPADAGSLSDNQVRLLCKDADGNLWVGTQYGLNKLPARNIADHNYTFERFFYNEQKKSGEDVLVIFEDHLRRIWVGTYESGLSRYDSQRNEFISFPIFDSSDGNSNVIHGILEDSEHYLWVSSNQGISKVNPENGNTLTFDESDGLVSNEFNNNACFKSQSGMMYFGGPQGLSAFFPDKIRTNRYAPSTVITDLKLFNQSVKVGATDGILKTSIMETHQITLDHDQAIFSLDFAIPNFINPDKNLYAYRLAGLEENWNITHKNTATYTIQRPGTYVFKVKGANNDGIWSEDITSMKIVVNPAPWRTWWAFSIYFIIVVVALYALNNIMLSRSRLRHQLELEHFENERQKSVNQMKLRFFTNISHEFRTPLTLILGPLEQILQDYKGSNKVYKQLKVMEKNSVRLLKLVNQLLDFRKFENKHEKLHAAEGNMVKFIEEIVLSFRQYAKIHQINYEFDKSSEEIKAWYDRDKMERVFYNLISNAFKYTNEEGSIHIKVWQEDKQFFFRITDTGIGMEREHLERIFDRFYEVEHTEASPKHQHQKGTGIGLAIAKGVVEMHGGVIAVESEKGKGTAFTVSMPLGKDHLQEDQIIKDFKDSEDVSTYVKINMVEAELMESEDSIEEVTHTVDEDKMPCILVVEDNPSVRRFIVDVFRGEYRTEEAENGMEGFKKAVQIVPDLIISDVMMPKMDGIEFCFQAKSNLKTSHIPFMLLTARTSLIFKFEGLESGADEYLNKPFNVKELKLKTRNLINTYNRLREKFASESIVKPSEITVSSLDEKLLKRALEIVDENISNEFFNIQLFSTELGVSRTMLFTKVKAWTNLTPNEFIHSMRMKRAAQILEQNKVSVAEVSYHVGFSNPKYFSKCFQKYHSATPTEYAGKFSVAEVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL4</accession>
    <name>A0A654DYL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted D-glycerate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="46942" checksum="00375D41E2431D01" modified="2020-04-22" version="1">MISSFLYVFLWLLAGIAVIVLLTTRFKVHPFFALIIAGFVVGIGVGMPVSEVLTHVKNGFGNILKSLGLVIVLGITLGVILEHTGSTRVMAGFIRKLVNEKRAALAMNLTGFSVGTLIFCDSGFIVLDGLNNSLARKTKVPIATMAVSLAAGLYAIHCMIPPHPGAAAAAEIIGVDFGQLIMAGIIVAIPTSLVGFWWATYAGKKNPVVLADEEEQESDLPGHSVIRAFLPIIVPILLIAIRSFIALDAPDQNWVISVLVTIGDPVIALAIGVLLAFNTKRGWQKNTVSHLMQDAVQKSGGILVIIGAGAAFGAVLVAINIGEYVNQAIPLEGLGILFPFLLAFILKTAQGSSTVAVITSASIVQPLLPNLGITTEMGYLLCVLSMGAGSIMISHANDSYFWVISKFSGVGMKEMLRVYSVATILMWLTSFIMVYLLSLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN0</accession>
    <name>A0A654DYN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021958">
        <property type="entry name" value="DUF3575"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12099">
        <property type="entry name" value="DUF3575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024853395" evidence="1">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="20595" checksum="0D89B7054521B8B0" modified="2020-04-22" version="1">MKKVLTSFFLIAVFGMTSVSAQDAEKKNTLKANPMGLIIGLGKINYERKLGDASSAQLGVSYFSYSSDGTSFSGLGLLPEYRFYVTKEALDGFYLAPFMKYNNFTLKNDEEDFKGSLNAYRFGAKAGFQWLMGKRKSFVMDLAFGGKYSDFNLKVKEGSEDDFDNENLFQGFSPELHFAIGYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU6</accession>
    <name>A0A654DYU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5554" checksum="667E5CA7BA641127" modified="2020-04-22" version="1">MLFIEFGRGRGAAAIFFFKAFRSWQDASSGIKRNSCREIALKVDDEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ00</accession>
    <name>A0A654DZ00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-fucose mutarotase</fullName>
            <ecNumber evidence="1">5.1.3.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.29" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036373">
        <property type="term" value="F:L-fucose mutarotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="109" mass="13090" checksum="EA8108F63EEECF2C" modified="2020-04-22" version="1">MKRYALTLDLKDDPQLIEQYIEHHENVWPEIIASIKGSGIRHMEIYQVATRLFMMIEAEESFSFEAKGRLDAGNLKVQEWERLMDQYQQRLPFAQWGEKWVLMDKIFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ42</accession>
    <name>A0A654DZ42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative beta-barrel porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025631">
        <property type="entry name" value="Porin_10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14121">
        <property type="entry name" value="Porin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="610" mass="71339" checksum="2C16C95E7D36C820" modified="2020-04-22" version="1">MSLLSAAQITDDSSELVYGSKTTLIIYESDLKNNQEKERHPDTTLYELEKFTKLDIERRKFQDLGNNGTALFPIFYPAPKEIGRTSGLSVYDPYMINPDQLKYYDSKSPHINLMVVFGGEGRSVVDMAFSRNVNENWNVGFDIYRITSDKQIGKSGQQDRNVVGTVFDLYTYYKHKEKPYSAMFHMVKMGYDIEETGGIYIEDLSQATKADLFEYQDSDIQLSEARSNDDRLNFHLYHQYNWTTPLQFYHQFDLKNQEVGFQDFKDVSSGTDVTYGGYYDQFLLGTDSTYERFTWKEMVNEVGIKGDLANIFYRLYLKRRDLDFDNLYQDPTPRFSEMFLGGYTRFDWKDQFNIEAKGELMQSGEYQLTGQLNSDFLFGSYKSVRYKPAFIYEKYFGNHHEWNQSFASAFSNEITAGLQVDLGFLKIRPQGRLLSLDKFFYFDEEKTAQQSGDVAIMASLGGDFNFRLYTNKALKEAFHLENEVYYTNTSGGGADHMEVPQFFYNGRFFWRGYWFKDTMGVEVGIDVHAKSQYYAMGYAPEIQQFHLQREFLIEQFYTADLFLSMKINNLRAFVKMTNINQQSNDGYFVTPYYPGQSQVMDFGVRWMFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH5</accession>
    <name>A0A654DZH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021471">
        <property type="entry name" value="DUF3124"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11322">
        <property type="entry name" value="DUF3124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="19073" checksum="53436F60B4614EE7" modified="2020-04-22" version="1">MKKISPVLLVFVALMSCQEKTVGSDEVTPVNWNKRSANLTTSDSLQKGVTYLSVYSQIYSRSEHRRHDLTATVSLRNVSIEDTIYVSRAQFFGTEGKLIRTYFDQPIFILPLETVEIVIQEVDNEGGTGGNFIFEWMINPGTPEPLFEAVMISTSGQQGISFTTRGIQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK9</accession>
    <name>A0A654DZK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CHU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="859" mass="96322" checksum="D542229413527CC9" modified="2020-04-22" version="1">MGLRLGMKKFSLFICALMFFFGLEAFHIVGGEIEFITIEPGVYRINLIQYRDEAQQQNTEPDPSVTVYIYSNKDNRLVSTHLLPLSSVSEVFYTNPECSIEELQTSRVVYTSVVELEPSGYADTKGYYVEWERCCRNLDIVNVENPGQTGMKYVVEIPPLWKNGKPFINSSPVLLKPLSDYACINQLYYTNFTGTDPDGDSLVYRLVTPLNSSSADALPIPQSKPHIPVYWAEGFSLENTVPGSPPLRITSKGLLTVNPKTKGLYVFSVLVEEWRDQVKIGEVQRDFQMLVREEGCDPPDPPEVGIQIPGNDSFDPEVDVLTYALEDDKCFDFIITNISAGEQITLRAVPVNFDEELDDLFSITQSFINPGQDTLVVQVCAPGCPPIRDGPFIIDLIASDDACPLPQMDTARLTINVEPPPNQFPDFTSFGPGYTINENEVLTLGFTATDANNDSLEMIMYVPGIEDPAEMGLFIEVTKSENGLMEGTLTWDTNCQIYDFSSLKNFQLALLPEDFDICEVENPNVVWLSMGVILPPNTSPEVTLGSDHVITARDGDVISFDVLATDLDQDTVNLSLQPLGFQGSGIGVSFAEASGVGSVNSLFQWKVDCSLLDLAEKRTYEFLFIAEDEDRCDEVNQDTVVFTVNLDIPENNRPEMREYADTVLKINVPFEMDISAFDFDAGDSVTIEFLNPSRLPRSESLFFERKTGLGEVTSTLYWTPECSLLDLGEESGFFEISFLAYDDACPVQKQYTMSITFEVRETQELFLGFEPPNVFTPNGDGHNDTYTLTNLTQPRQNLPPDNCDDAFQYISIHDRSGTSVFRSEQRDFVWDGKNVPSGVYYYVIKYDRTQYKGFLQVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX2</accession>
    <name>A0A654DZX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="337" mass="38958" checksum="979D4D2CF58009A7" modified="2020-04-22" version="1">MESRPPMNKDYSVLLENLLGRRYDEALRESIISEAFEESEYADCLKYALEGMQEIDPSYAYKTFHITKRIQEKIEKAFSAINLSVDFRYQGAIQTETHVVLYGGVELLVLAKPTDNKPWNTVSRMAREILEVLSGDLSFKEVDYSNKLDIRLRTMKPTCEVKILPAIWLQNPEYMTSKREIDRGISEYNLAKKTRRKYLPFLNIARINSKDTRCNGGLKKMIRLLCTLQRDAHEPIGLNNYQIGSMLYAIPEKQLKFNPEYSLSLIGVVSAQLNRIITDKNYREKLVSPSEKELVFGPSPMMKEEIQKLKNELDSLVADIQETLRAEGKTLYSEIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY2</accession>
    <name>A0A654DZY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="6721" checksum="1CC7B5823328B1B6" modified="2020-04-22" version="1">MLIIYLVLTSPSGSISLPILHLGEQPLEQNLFGLSARKVYHALLLTQEPVSSYLTFSPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E070</accession>
    <name>A0A654E070_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="20504" checksum="2879073D1943D07B" modified="2020-04-22" version="1">MKGLREFQIDIFNLGYKLHEFEFQIDNRLLGMYEHSLVEKGSGICKLSLEKSETMMNLHFHIDVKVELICDRSLDSFDYPIKLEESLIIKFGEDNYSLSDDVIVIKDDTATIDVSEFIYEFITLAVPLKKLHPRYEETEDDEPDLIYTSEDEDTDRENGEVDPRWEALKKLKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N9</accession>
    <name>A0A654E0N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ORF">MARINOS108_120516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="pyrH_bact"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="51"/>
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        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="26081" checksum="6233B020C8975B1F" modified="2020-04-22" version="1">MKYKRILLKLSGEALMGENQHGIDPNRLEQYAMEIKRVHEKGLELAIVIGGGNIFRGVDGEKSGIDRVQGDYMGMLATVINAMALQSTLEKHGMYTRLMSGLKMEQVCEPFIRRRAIRHLEKNRIVIFGAGIGNPYFTTDSTASLRAIETEADVVLKGTRVDGVYTADPEKDPTATKYTHVSFQEAYEKGLSIMDMTAFTLCMENNLPIIVFDMNKPGNLFDIIDGKEVGTLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V2</accession>
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        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Karimi E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
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        <source>
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        </source>
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    <sequence length="113" mass="12778" checksum="15B4914C90D4506D" modified="2020-04-22" version="1">MKINYHKKRFKAVTNSEHGEVDPQTIFHYSQEGDVLWAVYQGSSIKLGTITGLVKTDGSLEFAYQHVNTEGDIRSGKCISWPEILEDGRIQLHEAWQWNDGGEKGESVIEEIA</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="39"/>
            <end position="111"/>
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            <begin position="175"/>
            <end position="239"/>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="271" mass="31777" checksum="89622A5D6D1BCD0C" modified="2020-04-22" version="1">MSRQLSKPDPRRAEKLVAFDRLLTIMDELRENCPWDKKQTMETLRHLTIEETYELGDAILENDLEEVKKELGDLMLHMVFYAKIGAEKEAFDITDVLNGICDKLVHRHPHIYGDVEAKDEQAVKENWEKIKLKEKGNKSVLGGVPPSLPAMVKAMRIQEKARGAGFDWDKKEQVWEKVEEEMQEFKEEFNIADEQKINRERAQNEFGDLLFSLINYSRFIDINPEEALERTNKKFIKRFNYLESESGKDGKTLSEMTLDEMDAYWNRAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X8</accession>
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        </source>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
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        </location>
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            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
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            <end position="147"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="246"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="378" mass="41768" checksum="755EC97ED672CCF4" modified="2020-04-22" version="1">MITNPAITHRSNSQARQEETKDVMWKQLLSLTLLYASVIIGWIAYYNYQPKLLEAYNFTDLTLFLFVVQGIIMVITPMIAGRLGDRFRGKAGKRLPIISAGVSFAAMIFMATAFTLYTEPGPVFKWILPGLITLWLFSMALFTSPAISTIELFVPVKKLPTAMAMLTIVYGLLYSIEPIIVDIIDFLGAPLTFVAGGVAVFFSGLLMKKNTKIMVDVPKKTELAKSDYTYAFVLGIALGLATTLLFNMFPDWFEAKNFHFFGISGNGAVSVILAMVAILSLPLSKFTESRSIYFTILLSILASFAVVAGIYFTDNYALLVILIILFALFYSMMSVSFLPLALTVIRDQHKVFGVGVFFAGFELPNGILEAILVAQGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E190</accession>
    <name>A0A654E190_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
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            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024992286" evidence="2">
        <location>
            <begin position="26"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="453" mass="49057" checksum="4CD3C696696530BF" modified="2020-04-22" version="1">MEAFKQLSRISGLLVMMVVSSGALAQEYDDLYFTSKDRKQVKEEPKVENKSASTYQSYTNNTYTDNYSAHEVNPEYIARYQASKDYGTDSDYVDQVDDNATYSEPSYSNISYYPESYVDDQPGTTVINNYYSNSAGDGNGWNNRGWNSGASLWYDPWFGWNTGFNISFGYGNGWGGYYSPWYNSWGYPGYAGGFYDPWYGWSSPYYGGWGWSRWNRYNYAYTSGFYHGLYHGGYYSDNGYVSPRGRDVVVGSRYSRGGTVASGTRTNSRVNAPSSASGRADVSTADRRDYSRTQNEYFSRSRAGVSGTNVSNSSPTSSRSRVTTVTNGNSRSTQPTYSSRSGNSNSGGTLRNSGSTSGTRRYNSAAASSSNSNSSYSRSRSSGSSSSSSYSSGSTRSRSSSSYTPSRSSSSSSRSSFSGSSSGGSSRSSSGGSSSGRSSGGGSSSSRSRGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D1</accession>
    <name>A0A654E1D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized zinc-type alcohol dehydrogenase-like protein YogA</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yogA</name>
        <name evidence="2" type="ORF">MARINOS108_11638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="8"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="36112" checksum="C3BE9A241EEDF06E" modified="2020-04-22" version="1">MKAIVLNQQTNRLEYQEVPNPVVSKSDVLIRLKAASLNHHELWSLKEKNLQKDAPIIMGSDGAGVVESVGSGVTRFSKGDEVIINSSMNWGPNPRVQGADYQILGFPTDGTFAEYISIPEEYVFTKPPHLSFEEAAAIPLAGLTAYRALFSRGEFEPGQSVLITGVGGGAALMALSFAVAAEASVYVTSGDPSKIQKAVKLGAKGGANYKETYWPAQLQDLSGGFDVIIDSAGGPGFKYLTELANPGARIVLFGRTAGNIEDLSPRVIFWKQLSIHGTSMGTSQEFEQMLKLFSDRKIHPVIDAVYPLKQINEAFNRMDASDQFGKIVIQIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E200</accession>
    <name>A0A654E200_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">UvrABC system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uvrA</name>
        <name evidence="15" type="ORF">MARINOS108_20289</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="244"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="586"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="626"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD18551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="931" mass="104227" checksum="E8034B07A022B05C" modified="2020-04-22" version="1">MAKSIDQYDPKKFIIIKGARVNNLKNLDVAIPRDQLVVITGLSGSGKSSLAFDTLFAEGQRKYVESLSSYARQFLGRMEKPEVDYIKGVAPAIAIEQKVSSRNPRSTVGTTTEIYDYMKLLFARIGITYSPVSGKAVRKDSVTDVVDFMLRHEEGEKLIISAPMNIKKGRTVEEELKILLSKGYTRILLDDETAFIEDLLQTKVTKKHAFEILIDRAVVKNDEENQFRLADSVQTAFFEGEGRCKVNIVGKETREFSDIFELDGIRFEEPTINLFSFNNPYGACRRCEGFGKILGIDPEMVIPDPNLSVYEGAIAPWRGETMQKWNEPLVKNGIRFDFPIHRAVNELTEAEYELLWTGNEYFDGLNEFFKHLESKTHKIQYRVMLSRYRGRTVCPDCRGTRLRKDAGYVKINGASLTDLVLKPVDQLSGFFQNLQLTDHQQAVAKRILSEITNRLSYLEKVGLGYLSLNRLTNTLSGGEFQRIKLATSLGSALVGSMYILDEPSIGLHPRDTDRLIEVLLSLKKLGNSVIVVEHEEKVMEAADQIIDIGPAAGVHGGELVYQGRIDQMNGETDSYTAKYLRGDEKIELPTRRRKWNQSLTIEKARENNLRNINVEIPLGVMTVVTGVSGSGKSTLVKKILYPAIGKMLGVTGEATGKHDKISGDYKRIDQIEFVDQNPIGKSSRSNPVTYVKAYDAIRQLFSELPQSKNNGFKPAHFSFNVDGGRCEVCEGEGTVKIEMQFMADLNLECENCKGKRFKKEILEVKYKEKDISEILDLTVEEAIEFFDDKAGIVNKIKPLFDVGLGYVKLGQSSSSLSGGEAQRVKLASFLGKGGNIKKDHVMFIFDEPTTGLHFHDIKKLLDALNALVNDGNSVLIIEHNMEIVKNADWIIDLGPEGGENGGNLCFAGLPEDMVKLAENHTARYLKEKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E216</accession>
    <name>A0A654E216_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">asd</name>
        <name evidence="14" type="ORF">MARINOS108_140122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="36651" checksum="184850BC95B7A328" modified="2020-04-22" version="1">MKIAVVGATGLVGQEMLRVIEQRELPFDELLLVASERSVGKEMTFKGKTYKVISMQDAVDQKPDVALFSAGGSTSITWAPKFAENGTIVIDNSSAWRMDPTKKLIVPEINGGVLRIDDRIIANPNCSTIQMVLALGPLHERYTIKRIVVSTYQSVTGTGKAAVDQMMNERAGKEGDMVYPYKIDMNVLPHIDVFLDNDYTKEEMKMVNETKKIFGDDTVQVTATCVRIPTMGGHSESVNVEFEEEFDVAEVKALLSKAPGVVLEDDPKNNIYPMPINSHGKDEVFVGRIRRDETQEKTLNMWIVADNLRKGAATNAVQIAEFMLENSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E223</accession>
    <name>A0A654E223_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thump_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="44753" checksum="950407FB22E69A5B" modified="2020-04-22" version="1">MNNLEFLGSEDVQQFMLENQHSDLQKLLLNPPPQFKDQVKLIVDQILSRRKAKGKLPDWLDQPGVIFPPPLSLEQCSSPETAEYKSQLMSGKMLVDLTGGMGVDTLAMSREFDHTTYVEHSEWLCDVFQHNHPLLGNGAIEVVNASAEDYLSRFESRGHFFIDPARRDVSKKQVFHFENCSPNVLELLPLFQSKADLLLIKAAPMIDITLGLKQLQHVHQIHVVSVKNEVKEVLFLLNFKEISEPLIKCVNLRSEHPALSFTLSGEKDLEVTFSSVKRYLYDPNSAILKAGAFKSLTSIYDVDKLAPNTHLYTSDQLIEGFPGRVFEVVASDVGKKELGRHLPELKANVVNKNYPIKPEELKKKLRLKDGGDWFVMGYRDLHEVPRIALSKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E299</accession>
    <name>A0A654E299_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rsmI</name>
        <name evidence="8" type="ORF">MARINOS108_20372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="227" mass="25128" checksum="2BED96A5A9761C45" modified="2020-04-22" version="1">MESSTRLYLVPTPIGNLGDITFRAVEVLKSVDKILAEDTRTSGVLLKHYGITTPTESFHSFNEHKRTETIISRIKAGETLALITDAGTPGISDPGFMLARAAADEGIKVECLPGATAFVPALVKSGLPSDKFVFEGFLPHKKGRQTRLEYLKEEPRSMIFYESPHRLIKTLGQFAEFMGADRKVSVSRELTKKFEETVNGTLEEVIGYFEAKTIKGEFVLILEGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F7</accession>
    <name>A0A654E2F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ORF">MARINOS108_120468</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="426" mass="45759" checksum="79242ED612A325AC" modified="2020-04-22" version="1">MSIIESVHARQILDSRGNPTVEVDVYTENGFMGRAAVPSGASTGEHEAVELRDGDKSKYLGKGVLKAVENVNEHIAPEIVGISVFEQKLIDDVMIELDGTHNKSKLGANAILGVSLAVAKAAAEESGQSLYRYLGGVNAHVLPVPMMNIINGGSHSDAPIAFQEFMIRPVGAPSFSEALRMGAEVFHNLKSIIKDKGLSTAVGDEGGFAPNFSGGTEEALDAVLKAIDKAGYKAGKDITIAMDCASSEFFEGGKYNYAKFEGESGKVRTSAEQVDYLASLVEKYPIDSIEDGCDENDWEGWKLLTEKIGSKCQLVGDDLLVTNVKFLEKGIKEKAANSILIKVNQIGTLSETFAAIEMAHKAGWTAVVSHRSGETEDNTIADISVALNTGQIKTGSMSRSDRMAKYNQLLRIEEELGEMAKYPTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G6</accession>
    <name>A0A654E2G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplO</name>
        <name evidence="10" type="ORF">MARINOS108_120478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="16084" checksum="2DB4F4235A4FC5F8" modified="2020-04-22" version="1">MKLESLKPASGATKNRKKIARGQGSGKGGTATRGHKGAQSRSGYSRKIGFEGGQMPLQRRVPKFGFKNNNKIVMKPLNLDDLQALSEAKKLTEITPEILRENGLAQKSDKIKVLGRGELKAKLTVKAHKFSKTAQEAIEKAGGTASVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G8</accession>
    <name>A0A654E2G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="9278" checksum="4BC31919D03975FB" modified="2020-04-22" version="1">MLELIAMFSIGKTIRNIAVEKRLKPSPFIVNMVLLWLGFEFVGAFIGLTIFNNLMGGYFCGLAGAAIGGYLGYQRVVRAEPEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H6</accession>
    <name>A0A654E2H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024840875" evidence="3">
        <location>
            <begin position="26"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="AMP_N" evidence="4">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="496" mass="56290" checksum="AB62BDF215951140" modified="2020-04-22" version="1">MNMVLKSIAAVLLAGISFLSFGQKAAQLPDDFLSTDFHQERRDLLREKMPENSVAVFFANPVRNRANDVDYMYHQDPNFYYLTGHREPHAVLLIFKDEQVVTDYAFDELIFVRKHDALKELYDGARLGKEGAVDKLKFELAFEGPDFEDFNIDFSTFDKVLFYDFKEDVRDTKEEADLFDLIAAFKEKVNYGEDAMAINAEPKASNLDTKSLDELMKSLRGIKTKEEISLIRKAVDISTMGQREVMKAMKPGMSEQEIQGLHEFVFKKYQAEFEGYPSIVGAGHNGCVLHYIDNYKPAIEDGELILMDLGAEYHGYTADVTRTIPVNGQFTKEQKLIYDLVYEAQEAGRAACKPGATFKEVYAATAKVVNEGLVELGLYASTEEEDMINPETGRNRYYPHGCCHHIGLDVHDKGDYAELKENMVITIEPGIYIPEGSPCDEKWWGIPVRIEDDFLITKEGCELLSDLAPRKSEEIEALMKESSPLDNFILPSLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N1</accession>
    <name>A0A654E2N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_120538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="156"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="459" mass="52017" checksum="6AFA3089ACB36F5F" modified="2020-04-22" version="1">MDKELGKILIIDDDEDVLLAAKMLLKKHAKEVLIEKNPKKIPFLLNNDTYDLILLDMNFSKDITSGKEGFYWLEQILDKDPQAVVVLITAFGDVEMAVRALKAGATDFVLKPWQNEKLIATLNSAAKLKESYKEVSQLKQTSKQLQEDSNLAFKNIIGESNEIKEVFKIIDKVAGTDANILILGENGTGKELIARAIHQKSLRKDNVFIGVDMGAITESLFESELFGHKKGAYTDAKEDRAGRFEIANNGTLFLDEIGNLNMPLQSKLLTALQKREVTRIGSNQSLPIDIRLICATNMPIYEMVGESTFRQDLLYRINTVEIHLPPLRDRLDDIPLLANHFLETYNQKYRKNISKIAPNTIKKLQKYSWPGNIRELQHAIERAIIMSDTEVLSPDDFFFLAQKPENNNTVEADNFNLDEVEKNVIQRAVNKHNGNISKAAKELGLTRASLYRRLEKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U2</accession>
    <name>A0A654E2U2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">metK</name>
        <name evidence="17" type="ORF">MARINOS108_20515</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="114"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="244"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD19012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="45990" checksum="3FA008038D432428" modified="2020-04-22" version="1">MSYLFTSESVSEGHPDKIADQISDALVDHFLAFDPQSKVACETLVTTGQVVLAGEVKSKTYLDVQQLARDVIRKIGYTKSEYMFEANSCGILSSIHEQSPDINQGVDRQDPKLQGAGDQGMMFGYATDETENYMPLALDISHRILRELAALRRANDEITYLRPDAKSQVTIEYSDDNQPVKIVAIVVSTQHDDFDEESKMLEKIKKDIISILIPRVKAQLSPELQKLFTDDIKYHINPTGKFVIGGPHGDAGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYATRHIAKNLVAAGVCKEVLVQVSYAIGVVEPMGIFIDTYGTSNVSLTDGEIARKVEEIFDMTPYGIETRLKLRTPMYLDAAAYGHMGRKSETVTRSFTNGEGETKSMTFETFTWEKLDYIDKVKAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W3</accession>
    <name>A0A654E2W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14167" checksum="8A9CF35F43F8C505" modified="2020-04-22" version="1">MDAHKRLLAILHIIYGTFHILIFTFISLLANTLLPFIMAEIEDNSDETMLLVKGIMLIIRSVMFVLFVIVPLPSIIGGIAQLNNKKWGLTTMMVSGCLSLFNIPIGTTLGVYTIWVYLENKKPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E393</accession>
    <name>A0A654E393_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YcxB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="88"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="18615" checksum="3250180CE9F03F20" modified="2020-04-22" version="1">MIVRTKKYQLATGTYIKTALVSVLKEQWWVGLIYLAICAGYLWIPNWWWIIGATIGLVLYLLFWLIQFAGVTQLEQGKFMFQKLSYEITSQQILLKINPKQGMPMKWEQIKRVKKGKDHFVLFVSKAQLLYFPFKIFNNENEIKFIETVLKRKGFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L7</accession>
    <name>A0A654E3L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="18557" checksum="DB3B9CD20E328F1D" modified="2020-04-22" version="1">MRPQDIVILLKIAIKGEQSWNMKALSQELEISASEVSESLNRSSFAGLLFQDKKQLMRQALMDFLQYGLRYVYPQQPGALVRGMPTAHSAPPLDNEIMSDAPYVWPYYDGTVRGQAVEPLYPSVPAACLKDPVFYEVMALCDALRVGRARERNFAVEELKKRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T4</accession>
    <name>A0A654E3T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="389" mass="43760" checksum="F41224DE71FCEBC3" modified="2020-04-22" version="1">MKRTYIIMMALVVSLAGYAQKKPKITKANQARENGDLAEAKAIIDAAIEYEKVKDDGKTWYYRGLIYATIDTTSNEQYASLSDNALEEAVAAFNKADEIDPEGKGYYVTGMMGIPVLKEQQISNYYSYYYNKAVMAFQDSEYQTAVDAFEKSYYIVPDDTNAYINAAYAAHNGQLYDAATKNYRLAIDNGATSKDLYYNYVSILTSALDDKEAALAVVDEALGKYPSDGTLQKNRINLLINMGKIDEARGNLEQAIESEPDNANLYFTLAVINDELKEQERAIKAYLKAIEIDPNHFEANFNYGVILINQANETIKESNSLGMSKADQKKARELEPVINQKLKDALPQWEKVHEINSSDRTAMETLAYIYTQLKMKEKANAMNKKLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U6</accession>
    <name>A0A654E3U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VCBS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="532"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1183" mass="131250" checksum="E987FC28202917DF" modified="2020-04-22" version="1">MRRTNQKILNSWLFATFSFLCLVSCEEKTAFKSLPMDLTHVNFNNEITENDSFNILDFEYVYNGGGVALADFNNDGLSDVFFTGNMVPNRLFLNQGGMTFKDITTKAGVGALDKWSSGVAVVDVNADGWLDIYVCATVYSDPKKRKNMLFIHQGLEEGIPVFEDQAEAYGLADNSHTTVAAFLDYDKDGDLDVYLAINKMDPIMIPNVYKKSHTEALDRVDKLFRNDWNDSLSHPVFTEVSKEAGIIYEGYSLGVNVSDINGDGWSDIYVTNDYLTQDLVYINNQDGTFTNRSKAFLPHTSYSAMGNDVVDINNDGYPDIVAVDMLPEDNFRKKTMLMNNNYTGYINNEKYDYQYQCVRNTVQLNQGFSPVTGEPTFGDVALLAGVSSTDWSWAPLVADFDNDGYRDLIITNGFPKDITDRDFSDYNVEVGRYAKKSMLLARIPSVKIRNYAYRNINGVQFEDVTTAWGISEPSFSNGAAYGDLDNDGDLDYVVNNINDPASIYENLSNRKKESPNNWIRIRLKGRGLNPGGIGAQLKVYHGGNTLYWDHSPYRGYLSSNDPTLVFGLGQSARVDSVVVYWPTGEVEALSNVPVNENITLDIENAKRRQPVREAGSVQCFEALPDDVVAGYVHEEEEFIDFNVQPLLPHKLSQYGPGMAVGDVNGDGLDDVYMSGSRFKKGTFLIQQPEGTFIKQDLLPEINNKTKGEELGTLLFDADLDGDLDLYLVHGSYELTPEDSSYQDRFYENRDGRFVLNRGALPPFLVSGSCVRAADYDQDGDLDLFIGGRQVPLHYPLPASSYFLRNESDKEHIEFVIDEEASALMEDFGMVTDALWTDFNNDGSADLILAGEWMPISFLQNTKGTFRNVTATSGVGENVGWWNSLSAGDFDGDGDVDYVAGNLGLNTINRASTETPIGIYASDFDHNEGLDAVPTVFLPDEQGKLKEFPFFGRGDMIKQMTKIKADFRMHADFARAGITDIFSTEQLSGATAYHATYMESAYIENLGDGRFAMTPLPLECQVAPVYGMISADFNNDGNLDVLMVGNDYGNEVLQGRYDAFKGLLVVGTGDGTFRPTGMEQSGVYVPEDAKSLTYVINSEEDTKILAAQNMGPLKAFSVAISGQQVITLKPTDARVEYLDASGSKRIQEVYYGHTYLSQGSRKVLLPATASQVRVTTFSGDQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y6</accession>
    <name>A0A654E3Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024890146" evidence="1">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="33793" checksum="671DFC666A706E6F" modified="2020-04-22" version="1">MNKIYRLLLILVVVSFGFTSCDDEDFTGHSSLVPTSPTISISAPSSITIDEQDTTFSWTVTMSEAQIVDVAIYVTVAEGTTATEHDDFDIDNSNSRVYIPAGSTTGTAMVTLYADDDTREETEMLMIQIGDSRTANATITPTTVAITINNSPDFAPLETVTLTAVWDNGDETAVGESFCSSFDVDVLFLVEDFSGYHPDFSMATGSCPEVGDLDWADGHYWVTTNLYGSVDLGEFATDIPVSLQLTRYNNDGSVASSSTVLIDEQLHSDDDGSSLYLVGYITVTNGVYELFDADDTSYGDVSVQKMDLPAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E495</accession>
    <name>A0A654E495_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_50097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024987638" evidence="6">
        <location>
            <begin position="27"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="445"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="698"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="839"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD20680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="939" mass="107259" checksum="E52BADBB833280A9" modified="2020-04-22" version="1">MSNPPANKYAFFLLISTFFCVHCAFAQSNEFQDLVRSIEAIEAQDEPPTDSLWALSQPYFSAKSDTIKARINLLWGRHYFSEFQFDSAKHFMEEAIGYYAKAPGRKRDLAASLIYLGHLCYDIEDISSAISAYHRALAIYEELGMQAEAGNAYNGIGNSYCYIAEFNLSLENYQKSMELYSTIGDSTGVSKVLGNIANLYTVRKDYDKSLEYYEKALKWSVNNARQRMDHILGIGIIKEETKEYDGAEAYYREAVSLGKEVKDYIQLAYTYQNLAFLYVNTDQLDSVPKYMELTRELAEKYAIGNLHNNLNEINHQYLFKKGLYKEAYELLKEVRAKSDSFYNLDMTRQLQEVEAQYSTLKKQKELAQKDLELERASGELGRKEFQRNILIVGLLFVMVLVVMIYRSRRLKDRANNILKQKNQQIEEKNKEIKSMEEAKSRWFINISHELRTPLTLIKGPIRQALGAIPSNDHIYQDLKIADRNVGQLQKLVDEILDLSKMEDGKMPVNLGRTNLTELVLNALASFDNAARHTKVKLEFELDPQDPVVISADREKINNVLTNLISNALKFTHEGGKITVGLQVSEEGVALFVRDTGDGIPADDLDKIFDRFYQSTHSGGGQGGTGVGLAFCKEIARMHGGDLSVTSELGVGSRFELFLPGQRLSGADEIAQEEEALQLATPDIHEEPAQYRSVLKDKKILVVEDNADMRAYISGFLSRDFEVIEARDGMEGLEKLRAHTPDLIVSDVMMPRMDGLTFAREVKKHPTWKNIPFITVSAIGDETEKVNTLRIGIDDYLVKPFFAEELRVRVQNLIYNYSERITSQAEPQEEEISHEEKTLKKLEKEVYDNIDDSNFNVIRLAEAASMSERQLYRYIREMTGLTPANFIKEIRLQRAMDLIQKKVYKRTSQLSYAVGFPQPAYFSTVFKKRFGRLPAEYIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A3</accession>
    <name>A0A654E4A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">exoA</name>
        <name evidence="4" type="ORF">MARINOS108_20686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="29838" checksum="6C7A0A5435323E28" modified="2020-04-22" version="1">MAELHLVSWNVNGIRAIIKKDFLKDIKEMDPDILCLQETKAQPEDARTALELLPQYKSYLNSSKARKGYSGTAILTKEEPLEVTYDLGIEEYDQEGRVITAEFDKFFLVTVYTPNSGEGMKRLDFRAEWDKVFREHLEALNEKKPVIVCGDLNVAHTELDIARAKANYNKTSGYTQTEIDGMDNLINAGFIDTFRHFHPEEIKYSWWNYKFKARERNVGWRIDYFLVSKELGPALQSAHIYNDRFGSDHCPVGIKLSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C7</accession>
    <name>A0A654E4C7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">rnhB</name>
        <name evidence="14" type="ORF">MARINOS108_20691</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="14"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD19327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22346" checksum="0525A9C3497A6660" modified="2020-04-22" version="1">MMLLPYFQENQIEAGCDEAGRGCLAGPVVAAAVVLPPDYHHPVLNDSKQLTEKQRDELRIEIVKEAISFGVGVASPGEIDDINILNASYLAMHRAVDQLKITPEMLLIDGNRFKPHNEIPYECVIKGDGKYYSIAAASILAKTHRDELMRQLALEFTGYSWETNMGYPTRAHRSAIKAQGVTPHHRMSFQLLPAQLELFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E8</accession>
    <name>A0A654E4E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5899" checksum="DE9A8C0B5E355125" modified="2020-04-22" version="1">MITLWRGGRKYSTFCIFLIMDASRDNYYGYNKNLRKFAHEKPWEYEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F4</accession>
    <name>A0A654E4F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdhA</name>
        <name evidence="3" type="ORF">MARINOS108_20721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004642">
        <property type="entry name" value="Ser_deHydtase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00718">
        <property type="entry name" value="sda_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="302" mass="31816" checksum="10E96004F1E4BE14" modified="2020-04-22" version="1">MSILFDSFDEWRKYCSDENKPLYEPVLRYEREQKGKSEEEVWTGLSKAYLVMREAVQTGLTQEMNSFSGMINSGAKKVANLPLSVLSPEFQKLISRALAAKEVNSCMGRVVAAPTAGASGILPGTMVTLQEIHDLPDRMILEGLLIGAGVALIMEKRASISGAVGGCQAETGAAAAMASAAIVYALGGTVDQAFNSVAITIQCMLGLVCDPVAGLVEIPCVVRNASAAAIANSSAQIALADVSPVIPVDECVDAMGEIGQSMEAKYKETALGGLAATPTGQAISRRVLIQDIEIMDDEEVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H6</accession>
    <name>A0A654E4H6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">rlmN</name>
        <name evidence="14" type="ORF">MARINOS108_60095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="99"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="39718" checksum="388960995CA4103C" modified="2020-04-22" version="1">MMEKKDIRKMSLQQIKDYFASVDEKAFRAVQVWEWLWQKSARSFEEMTNLSKGLREKLESEFVLRPISIATSQKSNDGTIKSAFKLYDNELIEGVLIPADDRMTACVSSQVGCSLSCKFCATGYMDRKRNLDPGEIYDQVVAIDAQAKKDFNLPLSNIVFMGMGEPLLNYANVLEGINRITAEDGLNMSPKRITVSTAGIAKMIKKLADDEVRFNLALSLHAADDKKRNQIMPINESNTLEALREALMYFYQKTQNKITFEYILFYNFNDTLEDAENLLKFARQIPSKINIIEYNPISEANFKNTEEDRLEKFANYLKKNKVTVNIRRSRGKDIDAACGQLANKNKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J1</accession>
    <name>A0A654E4J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="16139" checksum="99962E63AD4DDB72" modified="2020-04-22" version="1">MNKSRPIVIVFFVIVFGLPIAWYFFLQAFGENRFDLPVLGEWNTTCINDSSFVVLDANLAMDFVNERNRIIAKMKDLQKMNYHEYPLDSCGLPGSIYLVDNGRMIRGEFELNREEVDRLLAEIDIYLLNLDNGTDYSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L8</accession>
    <name>A0A654E4L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024843169" evidence="2">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="19761" checksum="2DCA713AB205FD47" modified="2020-04-22" version="1">MRHLITLVFTLTAMGLWAQSPSTMERVEAAKIALITERLELTPEQAEKFWPIYREFSEQQRNLRKEFNNLRTNHNPQTASEEENQKMLEMGMQIKERQLGLERTYSERMQQVITTRQLMSLRKAEDDFKEMLMKRIREQQGQRDQMRQDRIRNNDNMQRKRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P9</accession>
    <name>A0A654E4P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="48"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="321" mass="35816" checksum="3454B260A4661C07" modified="2020-04-22" version="1">MSEMENEVEVANELHAAYQKLEQEIGKVVIGQKEVVRLLITSIFCGGHALLVGVPGLAKTLLVHTMAQSLGLNFSRIQFTPDLMPSDVLGAETLDQERNFRFIKGPIFSNVILADEINRTPPKTQSALLEAMQEGAVTTGGNNYILDKPFFVLATQNPIEQEGTYPLPEAQLDRFMFMIKLNYPSLQEELSIIKQTTSGDDYAAGEILTKEQIIKFQKLVRKVPVADNVFEYVVNLVHKTRPFTENADPISNEYLEWGAGPRASQFLILAAKCNALLKGKYSPDIEDVREVAKPVLVHRIVKNFKAEAEGKTEETIIDQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q0</accession>
    <name>A0A654E4Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023204">
        <property type="entry name" value="SP1917_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014580">
        <property type="entry name" value="UCP033199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09966">
        <property type="entry name" value="DUF2200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033199">
        <property type="entry name" value="UCP033199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="13984" checksum="A6BE6FDF87D233F3" modified="2020-04-22" version="1">MSSTAHHDERIAKMTFASVYPHYITKVEKKGRTKDELHQVIEWLTGYDEAKLNALIEEKVTFETFFQTATLNPNAHLIKGVICGYRVEEIENTLTQQVRYLDKLVDELAKGKKMEKILRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S0</accession>
    <name>A0A654E4S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusC/RagA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025029171" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="422"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1076" mass="119588" checksum="7991B1217C914DB6" modified="2020-04-22" version="1">MCTKITIRKSWIQILFLPVLVLVSMTSATAQDLTVTGKITDRETGEGLPGVSVVVQGTSEGTITDIEGNYKVTVAEDATLTFSFIGYANQIIPVAGKSIINVSMDVDVQALDEVVVVGYGTQKKSNLTGSVVSVTGDALKKVPVASVAESLTGRLAGVQISTTEGSPDAEVRIRVRGGASLTQSSSPLFIVDGFPVSTISDLSPSDIKSIDVLKDASSTAIYGSRGANGVVIITTKSGTEGKVTVNYNSFYAVKKIAKTLDVLDPEDYARWQYEYAVLDASEEGDYSSYEDYFGLFGDLDQYEGQAANDWQRQIYGRTGTTFSNDLSIRGGGQKFNYSANFARYDDKAIMIGSDYVRNNITLKFKNAPNDKIDLNFSLRYSDTEINGGGANEQNEVSSADSRLKHAVAYAPIPISGVSLSDDTNEQTSGDLVNPIVSTNDNDRLQKRNNYNIAGSFAWKIIDPLQLSTSFTVDNYNYQDNRFYGVTTYKARDRSPAYPNQPSALFSDRKEVRLRNTNTVTYDVLKGELHNLKVMGGHEMLFTQTNELEYEIQGYPVLFSADEAFKLTTQGQSIYADNNFSPDDKLLSFFGRANYDYKNRYLISAVYRADGSSRFKGDNVWGYFPSLSGGWKITEESFMSGLTKWVYLLKLRASYGLAGNNNIPRGQTVQTFESRNTTYINDVNSYWAASTIMANPDLKWETTETKNIGLDFGLLEGRVTGTIEAYQNNTRDLLIRFPVAGTGYEYQYRNMGETENKGVELSLNGIALDKKDYGLNFNFNIAFNRNNIKSLGVMDELVGTEVTTGWASTQIANDYLAQVGDPIGRMYGYVSDGRYEVDDFEEYDENSGQWVLKEGVVTSDGILTPRPGMMKLMDLDGNDTITIDDRRFIGNANPKHTGGFVLNAYAYGFDLTAAFNWSYGNDIYNANKVEFTSANENNQYRNLISVQEEGERWTNIDWNTGELITDPAQLAAVNANTTMWSPYMDRYIFSDWAVEDGSFLRLNTLTLGYTLPKAIIERARIENLRFYITGYNLFILTDYTGFDPEVSTRRKTPLTPGVDYSAYPRSRQFTVGMNLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T1</accession>
    <name>A0A654E4T1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_20614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD19202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="37201" checksum="5D1AC6F3E548C001" modified="2020-04-22" version="1">MVKIGNLEIGEFPLLLAPMEDVSDPPFRAVCKENGADLMYTEFISSEGLIRDAAKSVEKLDIYDYERPIGIQIFGDKIDSMRQAAAIAEEANPEIIDINYGCPVKKVACKGAGAGILLDIPKMQEMTAEIVKAVNKPVTVKTRLGWDDSTIRIVEVAKRLQDVGIQALTIHGRTRKQMYKGEADWTKIAEVKNHPDIHIPIFGNGDIDSPEKALEYKEKYGIDGIMIGRAAIGYPWIFNEIKHFMATGEHLDKPTLTERVAVAKKHLEFSVEWKGELKGIFEMRRHYTNYFKGIPDFKPYRTRLVESASFEELKSILDEIPEVFQEAIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W3</accession>
    <name>A0A654E4W3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+-binding EF-hand superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="21680" checksum="B3188CE162AD7009" modified="2020-04-22" version="1">MVSEFQRKKLIHFFGLLDSHKNGFLHADDFSEIAERIRIGLGYEANGPKHIWLAEKSAKFFHALLLEIPHKDNQKISQDEWVTFVSEQVIAQGNEDVLEEFQEFIIGFLFDLFDDNHDGYISTDEYVDMFVVYGIDIKYSAKSFIKLDINRDDRLSRNELLHAFETFLLSNEPNQPGNWIFGNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z8</accession>
    <name>A0A654E4Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="24426" checksum="028F5F3DCDD6E093" modified="2020-04-22" version="1">MKRLFILAIIIFFGYMSFGQGVSFSYLIPKNGYLSAPVSPFSVRGIGLGNKIGVETGATLYSIPGLAMEKLPFEYEKPLTGPHYALLVPMELFFKIPLGPMQIKLLGGGFGWWNINTRINEGNMDRAFRDYEGWEVLNSDFKLEDQLGLGWMAGIEFEFKVNDNFSITAESQYLKGAASSHLSGSYTGGTTASGIQTKAIDLEDTAILLEGIEFSIGVKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z9</accession>
    <name>A0A654E4Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Tyrosine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MARINOS108_20896</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="16">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="18">
        <location>
            <begin position="455"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="17">
        <location>
            <begin position="583"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VXD19798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="779" mass="89210" checksum="DC39698400014FC3" modified="2020-04-22" version="1">MKDFDQIENTQGGDEIFNSFDLEKFLFILRKSLLWIFLFIAASVSLAFVYVRYTKPVFQSTSLLKLDFESEATTLGLTSGFKGTMGTGLSGEIELLRSKLFFAKVVDVVDLDVSYYYYGRYLTDERYRNSPFVVSYKIKNLSFYNRPFDVVLNSEDSFELIYVQNGIEQSHTYKFGEDIITEDFNFILHKTDQFKYPESTGKYYFTVNSKDALISYLQGKITVSPENITARTIRISLVDYNRYKARDLLMAVDTLYLDYTKQAKNQALEQKIKFLNSQILVTEDTLETYDSYFENFIIEHRTLNLMADIQRVIENLIKLDSAQHRLDSQLSEALEFNSNYDNYDSLLSESAVPGMPMSLNGFLIEYRELLNQRKEKLRHYNENTYVIKGIDEKLEVFRQSIESLIPKHIEYLKERSKKLGAQSASLEKLFAELPSMRTSFDRNKRFYNLHESYLMSLWRTKMDLEITRAGTVTDFVILSPASIPASPIKPQPTIIYGISLAAGFLISFVFLLIRYLLHNSISSYHELEKLVNVPILGSVPEFTTHKLPLTKLVIMPSSKSAISEALRTIRTNMEFLNGNKVTKTITITSTISGEGKTFVAVNLGAVMAFSKQRVCVVDMDMRKPKVHLAFGDEAHFKGMSTLLIGKNSLDECITNTSIQNLDYIPAGPNPPNPSELILNDEYDNILEELKTRYDLVILDTPPVGLVTDAVLSMKKSDLQLYVVRSDYSKRSFVKSIENLKKMNRFNNLTVIFNSVKAGGRGYGYGYGYGYGYGYYEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E541</accession>
    <name>A0A654E541_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6505" checksum="E6B17E431556B53E" modified="2020-04-22" version="1">MNNHFPFTAKQLIKTTRIEVYHSLTEKFGSLEPQKTASGQDMDFQLDRLLSIIHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E558</accession>
    <name>A0A654E558_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit omega</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_90149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="11701" checksum="B324576B4DAF31E9" modified="2020-04-22" version="1">MATNASIITRDNEKIAEPTGNIYESIAVIGKRARQISAQQKEELNSKLAEFASSVDNLEEIFENREQIEISKFYERMPKPTSVAVEEFMEGKISYRSIDPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5L6</accession>
    <name>A0A654E5L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent transcriptional regulator, MalT-like, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_60106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="483"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="550" mass="62320" checksum="51EE7CA9B7DDF29D" modified="2020-04-22" version="1">MSNSFPAIARYGFFILWFSYSGCMGQSSESYLLSLYNQEKYQLVVEKADSILKGEPENLSRIYQIKADALYFLNQVEESLENYLLTVSVLDEYPLDTVYLIESYSHTGFTYKYLGKYLDAIPYYKMALSICRAADDSLEISNQLAHLGTLYSHLGMYQESAAYYNEGYAIDFALNDSTALAYDLVNLGDLKCSIMEYPQAVDYYKRALKVKSTKAGNHNTHVLRLGKLSEAYLKMGELDSATFYSRMAEEAAIDLNDSLSLAKQWITKTKIFNAKGEFPAATRVGNLCYNYFKEVGQGQYQVASALALAQAHNGLSNKDRADYLLIQAALIAEENGLLEDQALVYREMASEQERYGNQKDALTYYKRYQAIRDTLSKRDKQRAILVLDREYQTNQKEQQIALLEAKALVAELQLAERKQNIVLLLTVIFLLLVVGLIVILSIRRSNRLQKSLLTAQVNELRLQIRSLVDGSAEDLGIEIQQLNDSIQDPLSERELEVLKFALSDLTNTEIAEKVFVSVNTVKFHLKNIYSKLGVANRKEALKMAMKSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5W0</accession>
    <name>A0A654E5W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="58" mass="7151" checksum="127F4F8537330B81" modified="2020-04-22" version="1">MHTVRRFLWVCTIGFMIAWHNVYFQDDRLREEDRIEQTQLEEDEEKEAGDFDWESDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Z1</accession>
    <name>A0A654E5Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="66" mass="7855" checksum="91B0001EBF5BB0C5" modified="2020-04-22" version="1">MIRKRFITVVIRIYLNNLHLEKEQTTLTQTANSICHLADNLSYLRRQKGRICIKIERLNTIIPRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E669</accession>
    <name>A0A654E669_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="35752" checksum="AD13F8A9B1994735" modified="2020-04-22" version="1">MVGLIVEVSKKYPEMKKILSLLVFFFVAFALMGQDGESIDELFKVNYETPLTLDMKADLEKDPLDKAETKKKEKKKNPKIYYKIKAKRGFAKQGFGDRTVVELFYYLKDKDYEGPDPYARDFYWYDFKKKKIVNSLRVKRENAGVLHGHYEKKMGDQVIEEGYFYKGMKHGRWVRYNRHDILQEKEIYWKGWPKESLLAYYDFDRTQLKEMIPVHFGERQGEYYAYHPNGKLAVVGHYQFDHRVGVWREYYDNERVKREVTYPLEAFDKKAKPVITKEWDREGHIIYDRKKYEARVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6G8</accession>
    <name>A0A654E6G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipopolysaccharide export system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="360" mass="41592" checksum="5B704D2244642DD2" modified="2020-04-22" version="1">MKKLDWYILQKVLSTFVFVVFMLVLIICVIDFTEKNDDFMQNDVSREQIFKYYLTLFPYFAILLTPITAFIATVFVTAKLAAQTEIIAILASGVSFRRMLVPYFMAAVLIAAMSYVFMGYVIPNANKFRIGFELNYLKKPYFYSDRNIHLKIAENDYIYIDRYNNQRDIGYNVTLERIVDERLEDKLTAKRIHWDTATAKWSLKNWQRRQIFENTEIITSGGAAGDLDTLLNMSPSDFQNKERLQETLTIPELNDYIALQKSRGADDVQLYQIEKYIRYMQPFGVIILCFIGVIVSAKKSRRGTGFQIALGFLIAFIFIIFFILARAIAEAGSLNPILAVWIPNIIFSVVGVLMYNTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E721</accession>
    <name>A0A654E721_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic chaperone for outer membrane proteins Skp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025053805" evidence="3">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="20851" checksum="A3782E626F190823" modified="2020-04-22" version="1">MKKSALLVFCLFLFAISNTFAQKFGYVDTEYVLSRMPEYKEAQAEIEKLARGWETEIQGMYKKVEEMEAALQAEEVLLTAEMSAERRQEIDREWKEVKEYQKQIFGFDGLYFLKKKELVKPVQDQVFEAVERVAKNNRLQIVFDKSGDLVMIYTDPIHDYTDYVLEELGLGENQESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E745</accession>
    <name>A0A654E745_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25877" checksum="D91D9935F385F831" modified="2020-04-22" version="1">MAEHIMEDLSIDCVIFGFTDELKVLLVKHGEGISKGKWALPGGWITYEESLDAAANRILYLLTGVNNLFLEQLKAFGSVDRFPTKRVVTVGYYTLIKDTDYDVVAGYTASDVQWFSLNEVPELPYDHDEILTYALDQLKSRVKQEPIGFNLLPEKFTLLQLQNLYESILQIKLDKPNFRRKILGMKLIVDLGEKQNNVSHRAAKLYKFDQEVYQALKEHKFVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E753</accession>
    <name>A0A654E753_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="311" mass="34563" checksum="E0AB8656942FCF52" modified="2020-04-22" version="1">MKKITYILAIVIVSMTSCVQDPWDDVEESGWNNERSVLDIQFENQVGTASIERVNTETGNIEFTINTYAVEDFSAIKIMKLTLSYGGESSVEAGQTLNFDNASNSATLMVSSPTGKTREYTITVDPFEETLVGTYAITNVVVYGGTGPEYGGASVIPMMNKPWLWDETNGPSAELDNTLTFEFGGFTEEGNTYGTVINNAGDDGLYADFIFTRDPVTDVNNFYRKIPTGEGQWERNYTTGNINFTFSDGSTTTGTLIGAGTEDMGYDKSKTTENQAFVFSLSGTDDWDNIYSDYDKFVRRPRRYWIDVTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7L1</accession>
    <name>A0A654E7L1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrinogen-III oxidase</fullName>
            <ecNumber evidence="7">1.3.98.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hemN</name>
        <name evidence="11" type="ORF">MARINOS108_11897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:15425"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="1.3.98.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7 9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the anaerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.3" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004558">
        <property type="entry name" value="Coprogen_oxidase_HemN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000167">
        <property type="entry name" value="HemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00538">
        <property type="entry name" value="hemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="59"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD14346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="52974" checksum="86215785F8016FA9" modified="2020-04-22" version="1">MIIIRNKPPSPEFLCYMQDFISKYNVPGPRYTSYPTVPHWHTEDHTESRWKQAVSDGFWRNGKEISLYIHLPFCESLCTYCGCTTRITQNHKIESKYITYLLKEWKLYLATFGGQPIIREIHLGGGTPTFFSAENLKTLIDGLTYEATLSDDFVFGFEGHPNNTTEEHLKTLAALGFTRMSLGIQDFDQEVQKIINRKQSFSQVKEVTALARTYGFTSVNYDLIYGLPKQTISGIAQTIAQTIALKPDRIAFYGYAHVPWVKAAQKSYEQYLPSPAQRQSMYATGKKALMANGYHDIGMDHFALPTDSLYEAFATGKLHRNFMGYTTQDTNLLIGLGMSSISDSWTAFSQNEKLLSRYYERLDRNELPISRGHQLTTEDLIIRRHILNLMCNFETTWEVSELLEIGFGFNTNLLATLVTDGFIQWTDTGIKINDAGKPFIRNICMALDARLWRSSQQASFSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7T6</accession>
    <name>A0A654E7T6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="479"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="829" mass="90714" checksum="AF93B57B967E6893" modified="2020-04-22" version="1">MKHISNLPNEKRGSIPEGIGLRKLGFLIIAILMIITQSSVFGQSCWLEASGTQIVNAETNQPVILRAVGLGNWALQEGYMLNPQGCTGCPGTQWQMKLQYLNEGQSMAQVEAFYQSWRDNFITKADIDYIASLGFNSVRLPMHYELFLSSAQRAVRNNVITDLNFGHDTYKNSLQNWHDNDQLFNDPNLEGYRVIDNLLSWCADNGMYVILDLHAAPGGQGSDKNIADIFHDNNLWQFPVFQDVTNRLWDRISARYINEPRIAFYDLINEPNNVPGGGQAIHALLQRLITTIRDNGDNHMIMVEGNGWGNNYDYLEPFTFSPNWGLVYNAHRYWIDPADDWVSDSNPNQINRMANLVAFRNNHQVPVWIGETGENTNEWLSQNIDKLDQEGIGWCHWTYKRHDVGANAALMRIGGSYPTDGASAMAGVLESIKFQNCIPNTNTIAAVTQDLPAPWTSGCTGGSTPPPSGCTGSFQSISAAIQAEAYCDMLGIQTETTSDTGGGQNVGWTDAGDWLGYRVDIPTAGDYTVEYRVASQNGGGSLQLEGLGGGSSYGTKAVSATGGWQTWQTISHTVTLPAGQQELGISVLAGGFNLNWFKITPVANGAPTGQTIWLRGSNNQYVSSENGQNPMMCNRGSVGGWEQFTVVATGDGKVALRGTNNLYVSSMNGTAAMLCDRPSIGGWEAFEWVSLGGNALALKGFNGQYVSSENGASGMMCNRATIGGWETFTWGSVSGSRMAEESNGLEATEESFLIYPNPAVDLFKIDLRNLDFHQGVMKVTDLSGKVILTEELVKEVTEIGLSPGMKAGVYVITVESGDLKISRRMLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E875</accession>
    <name>A0A654E875_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="66" mass="7429" checksum="71F0ACEC5E274B1B" modified="2020-04-22" version="1">MMFLALLSCENKQNLVGNENEKETSTQSATKVRNYVESDSGYNNRPGRKKIASEGASDIYKSRLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8Y4</accession>
    <name>A0A654E8Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="81"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="430"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="566" mass="63916" checksum="AF426DFF81C64920" modified="2020-04-22" version="1">MNFNNKAKAENTYDAIVVGTGISGGWAAKELTEKGLKTLVLERGRDVKHIKDYPTMNLNPWELPHDDQVSAEEKKDYDVQLRTGYTIKESTKHWWVKDTEHPYTEVKRFDWIRGYHVGGRSLLWGRQSYRLSEMDFEANAKEGIAVDWPIRYKDVAPWYDHVETHIGVSGRNEGVPQLPDGKFLPPMEFNCLEEHVRDSISKNFEDRLLTIGRVANITQNHNGRAHCHYRNLCMRGCPFGGYFSSQSSTLPAAMATGNMTLRPQSIVMEVLYDPETRKASGVRVKDAETGEVQEYYAKIVFLNASALGSTYILMNSKSEYFPEGMGNQSGELGHNLMDHHFKAGAEGEFDGFEDMYYSGRRPNGIYVPRFRNINEKHPDFIRGYGYQGGASRESWRSSIAELGIGEELKDDIQTPGKWRMGLMGFGEMLPYHENKVTLNPDKLDKHGMPTFIFDCEFKDNELAMRKDMQSSAAEMLEKAGLKNVSTYDNIGGPGLGIHEMGTARMGRDPKTSVLNKWNQVHEVKNVFVTDGACMTSSACQNPSLTYMALTARAADFAVNELKKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9A7</accession>
    <name>A0A654E9A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22226" checksum="AB3ACC2D3F313644" modified="2020-04-22" version="1">MNKKWITIIVIIVAVFLVYNFFSGKYNSMVTKEEAVNTEWSNVETQYQRRSDLIPNLVNTVKGFAQQEQDVLIGVTEARSKASSINLDANNLTAENMQQFQAAQGQLNSALSRLLVTVEKYPDLKSNQNFLELQAQLEGTENRIAVARKRFNETAQDYNTFIRVFPNNFISGWAGFERKALFAADEGAEKAPEVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9B0</accession>
    <name>A0A654E9B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="29221" checksum="47F16F86D9F5C76C" modified="2020-04-22" version="1">MKLSKDLATEWWMDNLEGQLDAERKLQLDAYLKENPELATELRETTAFWTQMENLESPAPSEAMDLKFEAMLSGYQSAANRRAFDWAPLTQWFRANWQVGFAALIIGLVVGTLIIPKPTQEVDQLAAEVQDMKKILMLTLIEKPQAQERIKAVNMVSEMPRSDEKVIEALVFTLNQDPSNNVRLAALEALMVYGSNSSVREALVSSIATQDSPLLQVALADAMVLLQEKSAAAQFSKVLSSSKVDDSIKSKLESTIQTLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9S2</accession>
    <name>A0A654E9S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase subunit c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024797148" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="47" mass="3776" checksum="5B9C07886D4194CB" modified="2020-04-22" version="1">MMVMRCASLAGAGAAGAALGASLAAAGAGAGAGAAGAAGAGAAATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED85</accession>
    <name>A0A654ED85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase RsbW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15693" checksum="2A096F5C625576CB" modified="2020-04-22" version="1">MENKLTISCSKQNLAKIRQFVADILHRQAIKEVEAHKLVLAVDEICANLIIHSNHCNPTQTIEVYVDFQPAEQVTFVIRDQGISFNLSTYAEPSLDEIVSSRRKGGVGLMLVKRIMDKIEFSTEKNYNICKLTKKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDK8</accession>
    <name>A0A654EDK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="15382" checksum="2B2D6E441294D0A0" modified="2020-04-22" version="1">MAWMMIGCDEDVVMTTSDIRYGTSFGECIGYCIRETTLHDTQITVQAKSRDDGQATKTKVAELPTADAMAIRSGIDVHQFQQLPSTIGCPDCADGGAEWLELQVEGETVRVTFEYGADIDGIGAGVLRLRELTQEMDPSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE05</accession>
    <name>A0A654EE05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4528" checksum="117D5D2E478CCCAA" modified="2020-04-22" version="1">MPDYGSLSIFNTITPQIFGLIHFIEDKGDLSYKHTSLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSK3</accession>
    <name>A0A654DSK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="610" mass="70923" checksum="E614C061D55FC165" modified="2020-04-22" version="1">MRYLPWIILFIIISPFCALGQKTFEKKTYYDDQKTKLKEVITLLKKDSTLHGFYHSIYENGSLAIFGHYSHGESDSTWIYYFENGREKARGHYQKNQQVGLWKYHYENGEPKAVGSYQNNIKHGQWTYYFENGEEKSTGIYYNNDKEGIWNYFYEDGSLKAQAFFNGGKGIYKEFYPSGKLKTEGRNEFDKSEGLWTYYYESGEVEARGEFVNGLRNGLWKYFHKNGQLAAEGEFLKGEKSGPWKYYFPDGSLSSEGEMNSNQKDGFWKLYYQTGEIKGEGRYDQGTGEYIEYYASGKQKARGAMQEGRREGRWVYFSEEGLEDGAAVFEQGEGAYTGYYPDGSLKMTGTIKDDRRVGEWTLYNPDGSVAGIYRPVYEEQSPIFRTSNVKESEDVKKASDKPEYRYKNKKIRYFNPRINEYTGFILGTNPLWTLAGQLPISMEYYIQERLGYEAQIVAHKKPFYKDFSDRYNKVSTLGLDIHLKQKFYHEDTDLGMFYFGHQLSAGYLQHYVSTLDSLSGPPIKKRFTSEQMRFAYGFFIGDRWMQRASDSGLTFDLNLGVALGSRIFSNHAEAPFRFLFDELNQDKFYLPIIITLNIGYAGPKRRSTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSY0</accession>
    <name>A0A654DSY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024961488" evidence="2">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="6753" checksum="9D76978C10F7F800" modified="2020-04-22" version="1">MKKFLLSLMSVIALTLPAWAQETAGTAEPSLSQKLIFYGITIAGVAFLVAAWRRSKWGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT68</accession>
    <name>A0A654DT68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="22924" checksum="FB759B3836798612" modified="2020-04-22" version="1">MKPLMYVIFIIPMVCWSQLPGNSESINKKTPAKYPVQSGIISYTVSGGATGTATLYFDRNGWRALEHRTIQINRYGTMSTEDRKELTDGDYIFKINLTSGSGEKAKDERWSGLMTYKSNAQAFEAIMVSRGGSKVGMDTLLGKPCNKWAFEKGPVSHLWVWQGIPLKVIKKLPGLSYEQTAVSFTENPQIEEVTFTLPEEVIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTF6</accession>
    <name>A0A654DTF6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="415" mass="46287" checksum="18BD9505EC190CCF" modified="2020-04-22" version="1">MSKYAEIISIGDEILYGQTLDTNSHWISGRLDEIGIKVRRKITIGDEREEILNTLKESTERADIILITGGLGPTRDDLTKPLLAEYFGVGLKMNDEAFEHIRTIFEKRGREVTELNRMQAELPENCIKIDNKLGTAPGMWFEENETVYVSMPGVPYEMEGMMNDIILPKLKEKFTGGVIYHKIVKTVGIGESALAEKITDWEDHLPKSIKLAYLPTFGQVKLRLTALGDDRAHLEKEVGKEVEKLIPQIASYVYGYDNDELEKVVGDILLKHNKSIAFAESCTGGYISHLMTKVPGSSQYYKGSIVSYDYDVKVNSLDVDRKVMEEKGAVSEEVVLQMARSVRSKLGADVGISVSGIAGPDGGTEEKPVGTVWIGYSDEQKTVAKKFNFSKDRNVNIKLSALCALNMFRINFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTF7</accession>
    <name>A0A654DTF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ascorbate metabolism protein UlaG (Beta-lactamase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="104"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="37990" checksum="4BD200221800674A" modified="2020-04-22" version="1">MLFWIFPALMVFVIFALSLGKVISAPGHSGPQTKHFNGKKFLNTSGSQAKGVTEALKWIARRDQGPWAKNYETEVGPKPSNSSESLLITFVNHSTFLIQWNHLNILTDPIWSERCSPFSFVGPQRMRPPGIDFEELPHIDAVLISHNHYDHLDIPTIRQIEAKWSPVFIVPLGVKAYLDQLGIQNTIELDWWNETNMGITIRSLPAQHFSGRGMFDRDRTLWAGYLLEHGGKKVYFAGDSGYGDLFKEIGKKVGPVDVSLIPIGAYLPKWFMSPIHISPAEAVKVHQDVKSAVSVGMHFGTFPLADEGQGKAEEDLILALEAAGVKQGAFIIPEEGKAMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS1</accession>
    <name>A0A654DTS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_3" evidence="1">
        <location>
            <begin position="464"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="947" mass="106325" checksum="DD059370E424962C" modified="2020-04-22" version="1">MFLVFSIRAIPRITLIHPTQNFNVFRYAGGLAGTKNEKESMKYLIFIAVNCIIFPLLAQEFSISGSIQSHEDQSTFPGATVVVQNPGDSSIIKGSITDYEGHFKISGLSAGTYLIKADFIGYQTLYQKVDLTRNLDMGTLALVEDTKVLEAVEVVGKPVAAMQKGDTTQFSARAYKTAPDASSQELIEKLPGISTQDGKLQANGEDIQVILVDGKPFFGGDVNAALQNLPADVVASIQIFDKKSDKAALSGFDDGAQQKAINIITKPSRRVGQFGKSTIGVGTGGTYQGGASVNFFNNDRRITVTGLSNNINTTNYSADPGSMGDNINANGLIKTNNLGINFSDHLGSKFELNGNYQFSREENEQTERKLRDYALASDSGQIYSEDRYSNRLNVAHRLGLKLEYKINENNVLLMRPHLSFRNEESINDFLGQTTSGSSPVNATDNTATASYQDYDYDNNLYYSRKFGKKGRSFTSRLHTGWHTNEDRSRRYAENQFFNESDSLGILDQRTTRSRTGISWEVQASYTEPLGEHSMMELEYEIGDRIDDSDKLTYDADESGDYNALDTALSNTFKSEYLRQKFEVGYQWQNEGLKLQVETEFQRSDMSNDQVFPTQTDLNKGFSSLLPSARLDYRLSEDKRIELSYRTSTRQPSIGDLQDVIDNSNALQLSAGNPDLNQTYNHKARARFWSSDPENGKSLYASVESSFSQNLITNSTFIAEEPLEVAEGVILEQGSQFTRPANVDGYYQFRSYMSYGNPLEVIKSNIRFNGGVNFTRKPGLVNDVLNFSDAHNYRLGVSLNTNISETFDVNISTRSSYNVAKNSLRPSLNNNYYNQTTRLKYRWVFLGGFVYRADLRHQLNTGLSEGYDNSSMLLNMSAGRKFLKNDLAEISVNVYDLLQQNNNARRNITELYIEDQQSTVLERYFMLTFTYNIRHFSAGTTREDFEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTW0</accession>
    <name>A0A654DTW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5245" checksum="EE0E5A3C0EE025F0" modified="2020-04-22" version="1">MVELSTQKGEDLDRRGIFKDFAGNHWAIGNAIMTLGRKTMKGQMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU16</accession>
    <name>A0A654DU16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="683" mass="77981" checksum="FF59B21404890B3D" modified="2020-04-22" version="1">MKEVLIIGLIGLTLFTQAQVRSEIDLEDFAERRFQIQDDDINYEDLYESLLLYYTNPINLNRATRADLASLSILSPIQLNAFFNYIDKRGKLISLYELQAIPELDMATIRDLLPFVTVTETADGRPLPQRILTEENNYLLLRYSRTLETEEGYRREDGSGYQGDQNTLYGRFRVSHPDDFSLGITFEKDAGEAFAVNPDQKQYGFDFYSFHFLLENKGRMKTLAIGDYQMQFGQGLVLGSGFGAGKGAETVNTIKRSTVGIRPYSSVLESGYFRGAATTLSFGQLEATVFGSTLLQDGNLRTDSTYSNFEEFVNSIQATGFHRTQNELGGKNTLREISTGFALDYTMGPGLSIGATGLLSTFSRPLHKKPNNYNQYEFTGDQNLLGSLYASYNWQNFIFFSEVARSQSGGIGAVGGLLASLTPKLDFSWMVRNYDKNYHSFYGNAFSESSRNINETGVYWGLMYKPSRKYQLAAYFDKFSFPWLKFRVDAPSEGYEYLGRFTYKPARSVQMYAQFRQENKELSISSEDGNLSQLTQTIKQSYIFNIDYAIGRTFSFKSRVQGSNYEQENIKTHGIALVQDVNLAFWKMKLSSRFALFETEDFNNRQYLYERNVLYAFSIPAYNGTGFRSYLLLQYTASKSLSFWARYARFEYPDQDAVGSGLQEVAGSTRSELRLMIRYKFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUB5</accession>
    <name>A0A654DUB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="36319" checksum="8C3FD9ABBA22BF04" modified="2020-04-22" version="1">MKTRKLGNQGLEVSEIGLGCMGMSFGYGPPKDEKEMIDILHKAVYAGVTFFDTAEVYGPWINEELVGDALKPFHGEVVIATKFGFNIQDGKMAGLNSHPENIRKVAEASLKRLKVDTLDLFYQHRVDPNVPIEEVAGTVKDLIWEGKVKHFGLSEAGTQTIRRAHAIQPVTALQSEYSLWTRQHEKEIIPTIEELGIGLVAYSPLGKGYLTGKINESTAFQAGDIRNILPRYQEEARVANKALLEVICQFAERKQATPAQVALAWVLAQKPWIVPIPGTTRAHRLEENLGAASVRFSSDELEEMETASANVKVVGERYTEQMESTTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUC8</accession>
    <name>A0A654DUC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_10229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024929444" evidence="6">
        <location>
            <begin position="24"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="430"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="693"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="840"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD10784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="940" mass="108915" checksum="012A2AE1DBD7BE8D" modified="2020-04-22" version="1">MMKYRYYLCFLLLSFLTLTSTFSQEREQDSLRHLLHQLDETEPEKLIEAHNALAWSYRDIRPDSALYHANSALKLARRNGYVDQEIQSINYVGVAYRNLSNFSKAFEKYLEALKLSEEAGNGEQRGYSLINLGNLYLYQTNFHGAIKYFIQALDQAQSLADKRMVAYCFLNLGRSYKGIAEYGQAELYFKQAIEIRKEQGDLYGQLASEIDLAEVYLLQGDLRKSEQYHLSLIQRLEEMDNPRMLAVVYNNIAKIYLSRNELKKAEGYAYKAIESTRDINSRFEEKNVWENLSKIYANGDNFERAFESHVKYAELNQQLFSEENIRKIEQLKGQYEMEQQEVENEFLRKQSELNEQVIRTQRIMITVSVIGILLFLTMTIISVRGYLVKKKLSNEISKQRDEISRDKELIQQQSDKLMELDKAKSRFFANVSHDLRSPLSLIIGNLEMLREDEDVVLSSRAIKNLETGYKNCKRLLYLTDEINDLTKLEEGKINLKKEVVRFGSYLEMLAEMFVGTAEYKGVKLTCKNNIRKEETVFIDPRQFEKIFYNLVSNAVRHTSRGDKITIETFMEQDNILLHITDTGEGIAQESLPYVFDRFYQSKNNEYRSREGLGIGLALVKELVELHNGKITVESTLGLGTSFKLSFPKVVSESEHLTVPHTFTYVSERKHLYDDLDREERAGASVPKTEEMETILIVDDHPEIRYHIRQILEDDYHIIEAAHGIEALELLKHNEVDLMISDLMMPWMDGFELIESIKSNPELSKIPILVVSARISDSDQEKVLYQGINDYLQKPFQKKELMLRIGNLLQQKKNYEDSEGDVFGRLADKQNLDTVEKDILSRLEQIVMEKIDDENLSVYDLADAMAASERQVYRLVKKITGLTPFEYVSEVRLKYAEYLIRKGKVKNASEAARSIGLKNVTAFGKQYEKKFGVKPSEAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV2</accession>
    <name>A0A654DUV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor IF-2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="31869" checksum="0B9C923879C847AA" modified="2020-04-22" version="1">MPMRLGQLSRQLNLDTKDIVNFLAENNIEIKDHPNVKLDETAEQMVMEKFSDPKPEEPVVLIEPAEIQAIESESSEPESDILPEPQSEELEDDPVTEPIATTSDVEPAEPTSEEAIASETPDSEEEIEVIKAPKIELPGLKVVGKIDLPEPKAPKEDEEPEEPIEKEEKEESIPKVRLVHHSKRNSRPRLTPEQLEEKRLRNKRAKEKRIREAEERAKAREIQRLKDIKAEHYKKKLSKASAKQTTNKKKATSKPKQVTQQKPQPKSLLGKFWRWLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV72</accession>
    <name>A0A654DV72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="36281" checksum="165AE4122C5D13D2" modified="2020-04-22" version="1">MNRKNFLKTILGASLFTSIDGFASIAHIISDMNKEQQTSEKFASFGAIHLNITHLEKSTRFWTEIVGMKLLSTSGNTAELGTDVNTLVVLHETVKKKFQKGYSGLYHVAIHAPNIQEFASMVYRLALNKYPFSPVDHTMSKSVYLDDPDGINIEFTLETPERFKRVVTDRGLSIEDVNGNIRSASDRLDLDEVMSHLGSPNIDKIISNETYIGHLHLYANNVANSNSFYQKLGFESFNNLPQFMYADVGAGGSYKHRIAMNSWHGMNKPMAPSDSAGMRHFNIIFNNKEKFDLALNNLTGVETKDDGYWFLDPTGNKICLTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVB6</accession>
    <name>A0A654DVB6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="2">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="703" mass="80532" checksum="212A8AF93D7FFABA" modified="2020-04-22" version="1">MKILILSTLAISFLFIQCTQNMTHQEETTEEYEFTNHLINSTSPYLLQHAHNPVDWYPWGPEALNKAKEENKPILLSIGYSSCHWCHVMAHESFENEEIARLMNERFINIKLDREERPDLDNIYMDAVQAMGLRGGWPLNVFITPDQKPFYGGTYFPPDQWKKLIVSVSDAYVHKYDQLYESASQFAANIDQSEAEKYGLTDGGLALTLSDFDTAYDSLKNKFDPKWGGMNRAPKFPMPALWNFLLTYSHTSAQTKAREHCLLTLDKIASGGIYDHVGGGFSRYSVDGEWHVPHFEKMLYDNGQLLSLYANAYKLTGKSEYKRVLTGIAQWLRREMLHEQGGFYSALDADSEEEEGKFYVWTFEEVKELAGGDFSVIAEYYNVTKEGNWEPGKNVLRKLEDDKVLATELNLSVTELRDQVEQFNAKALEVRNTRVRPGLDNKLIAGWNGLALTGLCHSYQATGETIFADLATENAAFISQQLMTDKGLVRIYGLDTRGYLEDYAAVIQAFITYYETFFDETYLELARTMTNQVINEFFDPKENLFYYTSNQAEHLIARKKEIFDNVIPASNSIMAENLHKLGLMYDDESYKKIAFTMIYQMNKLIRQEPEYLSNWASISLLRLKPTAEVLLVGAQAQEQALQINKTYLPNKILMVSTTGSSLPLFEYKTVVNNETTIYVCFDKVCKRPVNNFTDALAEIHDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI0</accession>
    <name>A0A654DVI0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DM13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM13" evidence="1">
        <location>
            <begin position="204"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="33224" checksum="6557B400E0B5B08C" modified="2020-04-22" version="1">MRYREMYLLCLLSLASCIGTDFIDDPKDAAILTEVTSISLKVGETVQIEATYYYNMWVAKEDAELIWQSNDRSVASVDQSGKVTAVGKGQTKIQISYANEETVTVDVTVVENTDDVARVQITAPGSSLMINETIQLTARAFTMDDVEVTDKPVIWTSSNETLATVNSSGLVTAHANGIVSITAEIEDVKSPPFQLMIGTQARSGVFEGSGSYKAVGTVTLFIDDNDQLILTFSADFETSFALGTFVYLANSTSGTVVRSQGLEIAEVTTNGAKTYNVSLVNSSVGLNDYNYVILLCKPASITFGSAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ0</accession>
    <name>A0A654DVQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="65" mass="7044" checksum="B6163161990E8CA3" modified="2020-04-22" version="1">MNRTKVVKSAASGKGKLTTVPNSTTSRKSISSNEQKPLESTTTSQRLIHGELALKYVKSQLVHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV0</accession>
    <name>A0A654DVV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="21086" checksum="F07A6AAF697B3711" modified="2020-04-22" version="1">MKDSEILEKIAKGDETALDYLYKKYYRMMTNLVLKNNGTEEEAKDVYQEALLAFWQKAISGKLVLTSKISTFLYSICLNQWRKELDRKSRLSNEEVDSEEFQGHDQNERYKIVMQCISELGDTCKRILTYYYFDGLNMTDIAEKLNFANTDTAKTKKYKCKKKLDSLIKARYTTTDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW18</accession>
    <name>A0A654DW18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28048" checksum="A3A9409ED9B49243" modified="2020-04-22" version="1">MANTAVIVDESTSNPWGGGVAPMKASYGKLMMWFFLLSDAFTFSALLITYGMIRYSHPAYDGAVADFAFSQEYWPIPEKVFDAVPFLHGVTAPLVFVGIMTFVLILSSVTMVLAVEAGHRMDRKGVEKWMLWTIVGGFAFLGCQAWEWSHFIHGTDLSKNVGSNILQGASLTMNQYGPSNFAALFFFITGFHGFHVFSGVMFNFIIFYQAVIGVFERRGHYEMVEKVGLYWHFVDLVWVFVFTFFYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW90</accession>
    <name>A0A654DW90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="83"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="429"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="565" mass="64050" checksum="E1BFCB03F1E828D1" modified="2020-04-22" version="1">MLQDSKKKRTYDAIVIGSGASGGWAAKELCEKGLKTLVLERGRDVKHVQDYPTASKAPWQFEFRGTVPIDQRMDYQNLKRVSADSLHWNIKDEEQPFVEEKPFRWFRGYHVGGKSLLWARQTQRWSDMDFEGPVRDGFAVDWPIRYKDLEPWYTHVEKFAGIAGNKDGLPELPDSEVMPAFEMSCIESHFKESLKKNYGDTRHLINARCAHLTDPQPIHMEQGRSKCQNQNMCRRGCNFGGYFSSNASTLPWAMKTGNMTLRPDAVVHSIIYDEEQQRAAGVRIIDAHTKKMIEFYADIVFVNASTFNSNAILLNSTSGRFPNGLGNDNGLMGKYISWHNYRGKANAQFEGFADKVTSGRNPSNAYIPRFRNLRKQETDFLRGYAIGIGGGRWMGPDTQGIGLSLTENLLNPKHGLWSISSWMMGECVPVEENHLRLHPELKDKYGIPQIVMSCDWTENDDKMVADYVEQSKEMFEKAGFINITAEDTHSPPGSDIHEMGGVRMGHDPETSLLNEWNQLHQCKNVFVTDGACMTSTGTQNPTLTFMALTARAANYAVDEMKKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI9</accession>
    <name>A0A654DWI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phaA</name>
        <name evidence="7" type="ORF">MARINOS108_11024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="269"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="41703" checksum="4110BA1361856171" modified="2020-04-22" version="1">MQEVYILSLSRTPIGSFGGVLSSLSAVELGALAIKDALKKSGLESSEIQEVFMGNVISSNLGQAPARQAALKAGLDVNVPCTTVNKVCSSGLKAIMLGAQSIALGQADVVVAGGMESMSNVPYYVPRARFGYKYGHGTLVDGLQHDGLWEAYNNFAMGNCADHTAREMKISREAQDEYTVRSYKRVESATLEGKFKNEIVPVEIPQRKGNPLVITEDEEFSNVNFDKIPALNPVFSKEGTVTAANASNINDGASAVILISKRKMKEYGLKPEAKILGYADAAQEPLWFTTSPSLAIPKALKMAGIEKSYVDYYEINEAFAAVALANMELLGLDEDKVNVFGGAVALGHPLGCSGSRILTTLSSVLSDKNGHIGVAGICNGGGGASAIVIEKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP6</accession>
    <name>A0A654DWP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="26689" checksum="8E6910EE4B8B5D12" modified="2020-04-22" version="1">MKRSHSISFILLLIVVSCSSEKESDLKKDCSGSDLVVSIVSVEPTTCSDKGGLVASSTGGEGAVTFSINGTDFQQEGTFDALSAGNYTVTAMDQNGCTATVSTNIASESGGVTLAVASQSSAGCGSANGSVSLGASSGNGDYTYSKDGSTFQSSSEFDGLAAGDYTFSVKDESGCVASVSATIDTGVSLDADIMPIISANCAVQGCHGDVQSPQLTSKASVIGQAARIKVRTNAGQMPPAGRPDLTQQQIDLIACWVEDGALDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU9</accession>
    <name>A0A654DWU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="227" mass="26019" checksum="A4E61BE8C1B09670" modified="2020-04-22" version="1">MNKTLLFILIVFASNLCFGQQWYGVINDPDGYTNVRKGPGTNYEIVAKAQDNEIFYIEDSDSDWFLIYLIENNYLEGYIHSSRVRRISELQPIGEREYKSGLLTIKDKKYEFTIARSDFKKSEHEYELQDDKWVIKIDGTSPYGVDGNYPSTQISTFKFKIDSTTVNTPKSAYSDLYENNLGATSIFKNTDGTIYITMAENSDGAGAYDAVWLFKDGQYLKRVIIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV9</accession>
    <name>A0A654DWV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="31996" checksum="C972646C076FEF73" modified="2020-04-22" version="1">MKAFLILLLLFINADPTEIARINRLKNKAEVAFGHGQYDVAATNYRLLYDSIGVDDPTVGLNLAHSYYALGDTANAKLKYQSVASSSDKKLKSIAYQQLGVMAKTPATLSESLQYLKAALKADPANEEARYNYEVVKKLLDQQKEQQQDQDQQNKDENKDQDKQDQEKNEDQNEDQENQDQKDQEQQQKDQEQKDSEQKDDQKGDEEKEQEQEGEQKEEEKDQQNQNPSTKQKLEDMNISEEKARMILEAMKNNEIQYIQQQKRKATEQPDSGKPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ9</accession>
    <name>A0A654DWZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="19843" checksum="8B9531C40764E553" modified="2020-04-22" version="1">MAMGQEKLDFWIDDLTDSIRNRISGDSFQTEVSRLTKNDLKIITKKAGWNFSWHTELMDNSREVFKLTIVNNPSVIQGLMSVTIESDHIYMNLLESAPFNIGEDKLYEGVPGNMVAYACKLSFRHGHEGFVAFTAKTKLIKHYETTLGAYHFGGHKMIIPTDASKKLVEKYFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX53</accession>
    <name>A0A654DX53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025033302" evidence="1">
        <location>
            <begin position="24"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="120"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="853" mass="93643" checksum="27331F2D4CA440E2" modified="2020-04-22" version="1">MRKTLRNYALVASMLLASVASFGQSRITGTVVDAENGEGLPGASVVLKGTTNGTITDFNGDFSLTVEKSTATIVISFVGFQTVERTINLSETQSLGKIELAPGANELSPLEVIASVAVDRKTPVAVSTIKRAVIEENASNQEFPELLKSTPGVYATKQGGGYGDSRINVRGFNDENVAVLINGVPVNDMENGNIYWSNWAGLTDVTTTMQVQRGLGASKVAVPSIGGTINIITKTTDLEKGGNVYQGFGNNGYLKTSFSLNTGLTENNWAISVSGAKITGDGWADGTQFVGYNYFMNISKVLNDKHTLSFTGFGAPQVHGQRQNMHSIAKFREAPQGLRYNADWGVLNGDVVNVEDNFYHKPQFSLNHYWTISNKSELSTAVYYSTGTGGGGGYATEEDAVTGFEPTFNNYRTGGTYSPYDLDAIVDLNQTSSDGRALGYLRASRNDHRWYGVLSTYTQEINDNIDILAGLDGRFYKGIHFSEVYDLLGAEYVYDDNNMNNPNAALNVGDKRDYYNDGLVGWAGAFLQGEYSSGPLAAFLTLSASNTSYQRIDYFQYAPEDQATPWQNFFGYQVKGGANYNLNRNHNVFANVGYFEKAPDFDAVFQNFRNDINSEAENQKILSYELGYGYRSPKFSGNVNLYRTGWNDRTFTKSFQGDDDKLYYANILGVNALHQGVEIDFTYTPVKALKVIGMLSLGDWTWSDDVNSVNVFDEQQNIIETIDQLYIADIKVGGSAQTTGALGIDYNIIPAFKVGVLYTYFSKFYADYDPTNRTSSEIAGIQAWEVPTYGLLDVKARYDFKIGDLDANLFVNANNLFDVEYISDAQDTNSTAAGASVFYGVGRTWTTGLKINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC6</accession>
    <name>A0A654DXC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="203"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37465" checksum="65FF2039B16BBC66" modified="2020-04-22" version="1">MNKAIKNIKPLGFPWETQDPFLFCVYHKDDYPKGNAQMGPDASLAGRNLGQDFDTSNAWRMYHGDTVPGFPQHPHRGFETVTVVPKGLVDHSDSLGAAGRFGNGDVQWMTAGKGVNHCEMFPLLKQDEENPLLLFQIWLNLPSKSKFVEPHFAMLWNEKIPMYKSDDGKTSVTVVAGNIGEVKAPAPAPDSWAADPAHEVAIWTIKMDANAEWELPKASAGVNRSIYFYQGEPLTINDEVLQSHQCIELNPSETVTLKSGTSETRILMLQGKPIGEPVAKYGPFVMNNQDEIRQALQDYQRTQFGGWPWPKNDHVHPRERGRFAKHADGRLEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ8</accession>
    <name>A0A654DXJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="21221" checksum="8D76E7DDAE902438" modified="2020-04-22" version="1">MVYKVSSFMKNTIVISMLTLIVGFISCDQSSKESAAQQQASVPVEEVVLKDSVTFYSEDQQDAFLQAKLVLALKENDSVMVASEVLSRSNEGAPSLVILRTGPGDVELHEQWDDVAIIRSGSGVLITGDSIVGDQRVRGAAPIRDWLGGVIQNPSKRSLLPGDFVMIPAMVPHQYIPTPGDSLTYWTIKVRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU1</accession>
    <name>A0A654DXU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14210" checksum="9BCF3C4EEFDFD472" modified="2020-04-22" version="1">MKVLFEWLLSILAAFLLLQTLFYKFSGSDESVYIFTQVGMEPWGRYASGVVELLAGVLLLSQKYRAYGAVLGLGVISGALFFHLTSLGIEVLGDDGRLFYYALTVFISCILLLIMRKKDIPLIGQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU6</accession>
    <name>A0A654DXU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="47138" checksum="9645A6E37C342EE5" modified="2020-04-22" version="1">MNKKKILNDPVYGFINIPNELVFDIIEHTYFQRLRRIKQLGLTDFVYPGALHTRFHHAIGATYLMQKTLDTLRSKGVMIFDAEYEAALVAILLHDVGHGPFSHTLEFSLFKDVQHEQISLWIFDKLNKEFGGRLELAKQIFTGKYHRKFLHQLVSSQLDVDRLDYLKRDSFFTGVYEGTIGAERIIKMLNVENDQLVVEEKGIYSIENFLSARRLMYWQVYLHKTAVSAEAMLISLIKRAKKLTQSGKDIPATPAFRIFLERNITQQEFFDDKDLLDVFAMLDDMDVWGSIKMWQSHDDVVLSKLSNDLLNRRLFGIRLSNDKFSSEQIDQVLQQLLAQGYSAQEAKYFIQKGSISNAAYIAKGGSINILMKSGEVVDVAQATDLPNIKAMSKIVKKYYLCFPKNLSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW2</accession>
    <name>A0A654DXW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15984" checksum="DAE93D3FE0AAAB5B" modified="2020-04-22" version="1">MGFFRFERKDPNWCMIYKVVIFSFFIFGLVVCGFSQSTRDVNAPKPPSARYQSSKKAKKQFFLFRVFKKKDRQLTGAEEVAEFRKRIANTTRKKAKMEKKAAKPQYSDPLYFGHKKPPKKRPNGKKKFCKECGLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY23</accession>
    <name>A0A654DY23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24419" checksum="C56315E83A028502" modified="2020-04-22" version="1">MKTTILLVDDHDMIRDAIKFYFKDDPDYEICEEAQNGLEALEILKTKKIDILLTDINMPEMNGIELMESVRQNHKELKVLVLSMINEASYINKMIALGASGYVLKNTSKSEMRDALNKIMKGEDYYADAVYKTIVNSIARKAPKQRLTIDVPLSEREREILLLIVNEYTNQEIADKLFISTRTVESHKRNLLEKTGCKNVAGLVMYAVERNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY35</accession>
    <name>A0A654DY35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024945853" evidence="2">
        <location>
            <begin position="20"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="1159"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="1268"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2042" mass="210276" checksum="1FAFA893E23107FC" modified="2020-04-22" version="1">MRKLFALVLFFLLTHWSWAQTTYTVTNTNDDGAGSLREAMTLAEGSSGADVIDMTGISGTITLGSALPDITQDLTINGPGSSDLAIDGADTYRIFFIVNETAPTVVINDLTLQNGLAKGQDKNYAGAGAGMGGAIYADNATLSLENVIFDGNTAQGGNGGVAGGTHSGGAGPFDTGGAPGSSGPNGNPGGTGGFGSGGGVGGAATVYGGGANGRGGTGGYGAGAGAPGVANFQAPGTSPGGTGGMFGGSTNSFNGSSSSSARSGGGGGGLGGALFVRAGSAEFTNVTFSNNQASKGLGGAYSGDGQGKGGALFLMDGVTAEGVGVSFSNNTASNAGETDFDNNNNYGTLSIITNIVIESNPEDDEISEGEDVVFSVAVTGSGATYQWQVNDGSTWSDLEEDDQISGSDTEELSLTCLDIDWDQYQFRCVVEGTLNTETSEVATLTVNPAAALEVTITGQDFILCGAQEITFTAVAENVETTPAYQWVVNSEEIAEETDETFTYEVSPGDEISVILSEPGACYTRAAATSEIITIEESDTIAVTTDASSGQGSFAWAVALANTAACDQTITVDLTGLPDNSTINISGILITASRLKIVGPGRDLLRFEDTTPSGYSLSSQGMEYLEMSGFELYHDQENTDDGLRLESSMIVLSEIAVSGYGQNGISTVSMDNDFDQLFLSDNRTAILFYSSQLGGQTSSEVPARVSLTNSEFDNNEKSVFINDYQSFTTSTIENVVIKNNQDEYSGGLQINLYNTSGSFTTTHYITNVSFINAYGNGANLNASDGNDQIIAHFTNCTFSENGIRSYDDNLDDTTIDIAALANKNSEVILTNCTFAQNAIAIGYDEVSGGSALATIKNSIFVGNTISNVYTSAGAATITESNNIGYPTFSGVAADVINTTLTDPNGTGLLVHELVVCTSSALDAGDDSVAPETDQLGNTRSGISDLGAVESQGFINTQPQDLKDFLGNEASFSVVASADAPTYQWQVSSGGEYTDLADDATYSGTQTSELTIAELTDDLDGNSYRVVINGLCENISSGALLDVIHYPTSDDGSVTALEDATYSFQESDIVFADSDEDLFAGIQIISDVSLGYLLYDGDAVSTDVTYSDLTLLTFTPEANANGEDYATFTFKVADDSGEDVLSTLTYTMTIDVSPVGDAPTDMSLSKSDIDEDAAVGSAIGTLTTTDVDADDTFSYEVLTSIEIGGQTIFPIVASGDQLVTTVPLDFEQVPQYLIEVEVTDGYDLTFTKSFLLSTNDVNEAPTNLVLSVSTVDENTTVGGKVGDFSSDDQDTGAAEATFSLKDGATDNAAFTITDNALYVAEVFDFETRSSYEVTVLANDGNGGETEGVFTITVNDLNEAPTAITLSVAAIDENEASGTLIGVLSAADTDAGDSHTFSLASGVDDNDSFTVSGSDLSAAESFDFETKDTYTITVTATDAGGLTYDESLTISITDVFEKLDQVITFDVLPAKAFGDADFTLTGSSSSGLALTYASSDPSIAEISGTTVSILKVGSVTITASQAGDDTYNPATDVTQTLTIGKASQSITFGALEDKTFGDAAFDLTATASSGLSVSYVSSDESIATISGSTVTIHAAGTVEITASHGGDDNYAAAGSVTQTLTIGKASQSITFSTLEDKTFGDAAFDLTATASSGLSVSYVSSDESIATIAGATVTIHAAGTVEITASQAGDDNYTAAGSVTQTLTIGKASQSITFGALEDKTFGDAPFDLAATTSSGLSLDYVSSDESIATISGSTVTIHAAGTVEITASQVGDENYTAAGSVTQTLTIGKASQTITFGALEDKTFGDADFDLTASASSGLSVSYVSSDPAVASVSGSTITIHAAGSATISAAQSGDGNFLAAADVQQVLSVNKASQSIIFEDMDDIPVDSAPVALTATASSGLEITYTVTGPVTLSGNEITATGAGLVTVTANQDGNENYLAATPVVVSFEVLAGQSVVLSVLQEELTIYPNPFTDRFTLDVSSPYQGEVHLSLSDLSGRVVFSARYEKSAGRLVMEENVVLAPGIYTMILTVGNERELRRVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY41</accession>
    <name>A0A654DY41_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3347" evidence="1">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="19087" checksum="9DC5785391F93812" modified="2020-04-22" version="1">MNHINFVKMKKYILSLGLVSLLMACSNPNNERQNESQVSAVPELEEVLVAQSSALSDYMILKDALVKTDRDQAKNAAGKLAKSAASENWNTDIIKAAEVIATSEDVETQRTAFKKASDSLIVMLKANGANDGIYVQYCPMAFGTGANWLSMSEEIRNPYFGDKMLKCGRVEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD1</accession>
    <name>A0A654DYD1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="2">
        <location>
            <begin position="51"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="18638" checksum="9B2FF60F5D0A6177" modified="2020-04-22" version="1">MKTSKKILLIVAGIFGGLLIVSLISFRKETMAVVSDIQARSPFAPVAVEGFDQVDFSGKWNAKIRFGLEQRVLLQTGHAEGLNLVLENVDGTLYLKTASNGESLDTIHVKITVPRLRTIRASGGAMINYADFDSDTLRVVLEGGSTFSGYENVFDYTSFEVSGDSQIKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW4</accession>
    <name>A0A654DYW4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="9" type="ORF">MARINOS108_110062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="44212" checksum="00D30F80FF28C7E5" modified="2020-04-22" version="1">MSDQKKVLLAFSGGLDTTYCSLYLKELGYQVYTVTVNTGGFTKEELDKLEERSRSLGSESHSNVDVTEEFYQKAIKYLIAGNVLKNNTYPLSVSAERVFQATAIAKEAIRLGVDAIAHGSTGAGNDQVRFDMIFNILCPEKEIITPIRDKRLSREEEIQYLIDHGVSGNWEKSLYSVNQGLWGTSVGGKETLTSDQFLAEAAFPSQLKKTGEEVVEISFEGGEPVGLNGKSLTPVQCIEQLNTIASAYALGRDVHVGDTIIGIKGRVGFEAAAPVILIKAHHTLEKHVLTKNQLLMKDQLSLTYGNLLHEGHYLDPVMRDIESFYDSTQKYVTGTVKVHLAPYRFYVVGITSEHDLMQSSFGKYGEMNNSWSGEDVKGFSKIFGNQNMIYHKVHQTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ2</accession>
    <name>A0A654DYZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="55"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="280"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="507" mass="58678" checksum="6CE0880463F0809F" modified="2020-04-22" version="1">MNRIMKKYTLTITSFILLSLLTVSCFDLSESVYSEIPVDDFFNSEKDVIAYAGRAYVKLQPYPEEQRLWSLGQNASDEMVIPQKHNGEWYDQGRWEEIQKHTLNSATAGNKILTKSWDMVFEGITACNETLLVIDPIEFENKERVLAEIKILRAFYYYWAMDYWGNIPFSIDFSEKDPPQQKDRAFVFDFIVQEILDNVDAVQDVPTAEYYGRVTKGMAYTFLAKMYLNAQEWIGQNKFAEAVLACDQVIALGAYQIEPNYFTNFEVHNEGSRENIFVIPYHPQLTDEHFYWQNLTLNSASTATFNLAGVPWDGFVLQPDFFTKYSENDIRRNSFLFGQQNDIKGDPIVIGGEPFIYSPTIQDYNSRGEWEGARCAKYEYQEELSYDVVDMENDFVLFRYADVLYTKLEALHRLGRAGEFIDDPDLQLIRTRAGLTPYTVGDLTDSELLDELGREFAWEGHRRQDQIRFGVWGNSWWEKPASGTAKKLFPIPQSAINTNPNLTQNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ41</accession>
    <name>A0A654DZ41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter (CPA2 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_110102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="539"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="618" mass="69041" checksum="3F55EE3394B1C69A" modified="2020-04-22" version="1">MEFFNYWPLFVIFIIAWIVPLILSWLEVSKVPSVIVEIVMGVIVGPYVLDLIEPTPLMDFLAGTGFLFLIFLSGLEIDVPKMISSLPKGRIRIIDILSNSLLVALFIYFGSLFLSIPMAWLISQFIEIDLIFYILLFPTVALSITVPILKSEGELTRKFGQIMLMEGAIATIMSIILISVYSGVLKNGFQVELLLFTVIFIVFILTYVIGRRLIKVRTFQKVLYTLEHAASQIRVRGTVALLLFFVLIAYLIDTELAMGAFFAGVLLSLFINKERSALVFKLDGMSYGFFIPIFFIMVGVQLDVSALSQFGESIPFVLTLVLGFFATQVLPALILIKVFGLKKALAGGVLLTARMGLTIAAAQIGLSLQVITAADNAAIVAAAIFTSLLSPLAYKFFSQEEDLYYSIYIFGGSKASLLLAERMKMHDIPCLTIIQNQAIIPDFEQKNLNIWAVDELDTSVFGELDIRTPDLVIMLTESKKLNQQLALYVKNKLNHSKIILRKQSASHELVDTESDLKLIDIDELLAGYVEDMIVRPETLTSLSESFGMYRIEEILLTRKELHRKQVMEVAFPPSGSLVVLRRDDEVFIPHGDTHLLLGDTLTVIGNSTALTEFRDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ46</accession>
    <name>A0A654DZ46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_110045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="82"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD15869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="378" mass="42756" checksum="051E765A28EBA80C" modified="2020-04-22" version="1">MISPQASGAFKAFAESKASSLLLILLWLLAQLIAYLLFGIQTPVDTKEYMTDALSISSGAWPSDHTFWYSGYSSLLALIHWFGAPYEVIIWIQLMASALAAATLYRLAQLWGGESSAFIATLLYIGWLEIHQWTMILYTDSLFTSLIILSVYAIYFSHHHLQYLGAFILILLTAFIRPVGALFLVSLLSAMLFHSSVKTTPVPYRIGIGLIVLAGFLILLNFILRDYVSSFINSYSQAEIIYPGRSILTPPKSLEIPDTDLQPLVRLVSFMVYNPLYFLQLSLIKGLLYLGHVKPYFSIIHNLIIVLSLYPIYYFSIRGWKSVKMNPLKAFITVFISSQILMISFTSENWDGRFLLPVLPWIFLMASIGLSRSFFESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ81</accession>
    <name>A0A654DZ81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="52695" checksum="D6DC59E218335889" modified="2020-04-22" version="1">MIFGYFSSRKSNSLPGLRAPYSLQWFVWEGKSARFGRERLTARGLLVGCCDQFRNFKNSSFMKKFFSIVITIFISTYVWCQTETIDNGDLKFTGNRDNVISLNGDNTTNKPMLVIGEQQLYGLGFKWSSVLDLDIVQFDNQNFFSTSPTKLGHFRVRDKVFYWSGNVGIGVDQPSKKLDLALGNDSDFLRVRRYSTTGRSQLALADESAQEIWRFGMTGSGSTNFAFWDGLRDVITMERQGDLLFNPVNNIGIGDTNPSKRLTLNSGDMLFNGNRDNILSVNGDDTSNKPMLVVGEQQSFGVGFKWDSGLNLDIVQFDNQNVFTTTTPTKLGHFRVRDKVFFWSGNVGIGTDSPDSKLSVNGTIHTKEVRVDLIGWSDFVFENDYELRTLEEVEQHINDKGHLPEIPSETEVKENGINLGEMNAKMLQKIEELTLYLIEQNKQNRSQQARIEQLERKISKLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN3</accession>
    <name>A0A654DZN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="1802"/>
            <end position="1877"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1879" mass="202431" checksum="931E987A886829BE" modified="2020-04-22" version="1">MDDITNSANVTTFAESNVTGTTLTLSHPATNDLLISGNGLTNFSYNSGGTSSVKFSPIAAGAGVHTLKYRWENNVSGVTASFNAIYMTVNQTENVFDLNRQELSFQKVMGSGEIYLYGSDGVSDPTYDINGVDGPDDDFYFLEVYYIENGSSLTGYGEVGISEADGNIVNRLINYVPGSPTANIPTSVVDGDWIFDPSALDSIAGIPSREVDTLKFVSVLSQESDGALIVKDEAFVYLYPNPTVTFDHTVTGQKLINDFYCADDGDFRIQASIYTYTGSGGVDSTGYITNGYLLYSSSDGVAPYELLADSTSSGSLGVVNTFDPTSVDPGYYQIVYISKPQTVAATTDTGRFEFRVLSVAEAPTLDLASNPDLDAISAFDSGTGEYIIEYCGGQSIEDVVVSSTGASTEFFKWYLDENGNNEVGTANLTGANDTTLNVLNEFFGGNIPNSRTTVNFWISELSHVGITGANTTSFSGCESSLRKVVVEIYAVPSPVTIVDNILATATNQTNLGSVNLLGEASNVNSSGYLYEYCEIGGSSASLETIVINSGLNNEDLTETYFTIYDGDASTALATFDPSDLDGSNNLNLAELDLLGATGYDPIAATSDTFYISRTDFDNAVGSDSYPFTGCESDLRKFIISVYQIPAAPVDSNFKGGAGSTSRQASAVDNELNYYLCFGEEEEFIQLESPGLTGSKYTWYKDDGTGTAPGDPLVAEAFNGRLITLDELEDQGVFDDSVSATYTYWVTQTKNENSSTDFYGCESDPMKIMVTVFPDPSTIAFDESGVRELEVSYCEGDLGGVGFDITANANASFGYYSSNGAGTIASSRTSLFGGNIDPDGQVQVTAQSLLLTNAIQGTYYFLIAQTNDIAPNGSTFPGCESEVSDMAYLTVHVYDIPLAPSIVDATMVYCEGDGINDVEVSGEAGSTFKWYLDSNNDGFPDDAFNPLYTETPSGTSSVATASNLGLVGANDGIYRFVVSQTQDIAAGVDDFEGCESAYTKFSVTLYSVPTAPIANTPAPQCNRNVTSTSTIINYSGVETTAGETVFKWYNEDDVEVQQTTLTNPVLGGQFSVNLEGFVGDTTIYVRQITNIVVGESFAGCISDPTPITLTVAPVPVVSTLANNQRIDVIQACDEQNIILEVTLDNLDVSQASFVWSAGRTAAQAIEIETSTQTDVGVRTRRIEFDPKSVGADGLAAGDNYFEVKVTDNNAPAGLTGCVESASNTTEIGTTPQPKMRWDGITEGNTTTFVFGDNNPTQSNNYDIALIELSIPALGEVVTVTDIEIQNRNSIAVGEFTFQESGTYELDLFYQSTSGCVASITRSITILDRVVVTEDITYDFENGTSGWYADSTTVDGFGTRSSPVWELGTEESVNYASPADQSGINSTNYWATGLNSAYASDEDAWVYSPAYDLSNMIQPTIGFDHARELTFTDGVVVQYSTDDGLTWILLGDYTRNTNSASGLEWYNSEELSGAPGLVTFNSRSDGWTTTSAWKFSAHKLPSSFAEVRFRIAMGSTAGDKVDNNNNVLHGFAFDNFRIYNKDKFILIEQFSDLGESSQDVSAEIKTRIDSEISSDAIWINYFQGEEDEVSQRNQSDPGARSNFYGIDSRPKSLLSGKKTSDTDVVGWSLNSYKARALEGALFEIGDIIIGGESDELVITASFISKIDLPAKSEVSFRFAVIEKQITDPEVIAANGGQPLYNVLRKMLPSSAGLTYSGAVTDGQSVFFNGQESVSVSWDISNVYDVNELSVVVFVQVDNVGGSTANELNKLILQASERTNAGAGKVVPLLTGLDNRLEDIHNFAVYPNPADKVFKVQFETAPLNDMDWILYDQVGREVITGAVKSGELEIEIASKELPSGIYLIHFFNDQEKWAPQRVMIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP7</accession>
    <name>A0A654DZP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="21697" checksum="42C177A930E5751C" modified="2020-04-22" version="1">MSKKSYRKELIEWTIIVVVGLTLYVTGLHTEVIGQIQRVVLATGIMQPEADDEKATASYDLRLSNIAGKPVSFSTFRGQTIFLNFWATWCPPCIAEMPDIEDLYQKMGKDVTFVMISLDEDRDKARRFVDRKGFELPVYFLESPLPSPYNPSSIPTTYVISPDGQVVLTRHGMAKYDTEEFRAFLSTLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT7</accession>
    <name>A0A654DZT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="20509" checksum="0F8DDCBAB8FEE574" modified="2020-04-22" version="1">MNKLLPNNLEYEILDFTFEETEYGILKGRNFQLILVNEQERYIPFLSKNESKSLKKDTIYVRRGTQSVQANYEELQKILNQRIESEYDSSSEMKLDEHLAQLKTLYAHIKKYYYLDPSWDLIPEEELESIMAEQEHYRRKNNNYPNEDFEEFVVRLIEIKKQVIISGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW2</accession>
    <name>A0A654DZW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pth</name>
        <name evidence="4" type="ORF">MARINOS108_11109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="20927" checksum="A4744FBBB38995BD" modified="2020-04-22" version="1">MKYLIAGLGNIGAEYELTRHNIGFLILDRLADREGLKFEHDRHSFITELKYKGRSIHLMKPTTYMNLSGKAVNYWLTQLKIPKENLMVITDDIALPYGKLRLKAKGSAGGHNGLKNIEQMIGGQDYPRLRFGVGDGFGKGQQVDYVLSPFNKQEMDEIVLNMDLAIDALLSFCTIGLERTMNQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J3</accession>
    <name>A0A654E0J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7693" checksum="FFBD1D4044F6F6CB" modified="2020-04-22" version="1">MVAELFVGDADVKIMYLIWQSSCMNARMIQAIFKSYHWLWHVSLDFFNIFNRSILYNILRSETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J9</accession>
    <name>A0A654E0J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="50603" checksum="D06994B4BFE2C05D" modified="2020-04-22" version="1">MQHIVILGNGIAGITAARHIRKRSDDRITVISGETDHFFSRTALMYIYMGHMKYEHTKPYEDWFWMKNRIDLKKGWVSSIDFVQKSLHFDSAESMTYDKLIIATGSVSNKFGWPGQDLKGVQGLYSKQDLDLMEENTKGIKHAVILGGGLIGVEMAEMLHSRHIPVTYLIREKHFWDNMLPQEEAMLIDHHLAEQGIDLRPETELDEILDDGQGQVKGVKTKSGEIIDCQFVGLTVGVSPNISLFKDAAIDTDRGILVDEFLQTNIPDVYAIGDCAQLKHPLPHRRAIEAVWYAGRMMGETIAQTITGTKTSYQPGVWFNSAKFFDIEFQNYGVVPPQCPADCTAFYWEASDKKKCIKVIFETDTKAVKGVNIFGIRNRHEVWDDWISKEKSIQFVMENLPKANFDPEFFTHWEGDIQQKFNAEFPNLRVSVRKKSFLEKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T0</accession>
    <name>A0A654E0T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane starch-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_140003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024958146" evidence="5">
        <location>
            <begin position="28"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="110"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="380"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="504" mass="55629" checksum="FE4D346A9341761B" modified="2020-04-22" version="1">MKNLILKNTAMKAFRIFILLFSLSLFSCEGLLDIDAENTISGEVLTDQAAIEEALNGAYYNLMGIYDGTGGGELLGGDFKLFPELLSRRNSNEISWDDVNAPPYSDFIDKDILKTNLRVESNWRRAYEVINTVNSILANIENVENATAKARIQGECQAIRGILYFEMVRLWGPQYEEGGSSLSVATLPLLTEPITEIGEIQTPELATVQQIYTQVETDLTTASSLLESSGKNGTAISYYACQAYLMRVALQKSDFESAETYADNIIESGAFSLVSNPLLAFNNNTNSTEDILAVQQTTANTTGDKSTGTGLANHFSSLTESGLGTMRILEFSLNSSFISGSPLFSDDDIRGIVDYDVDEQTRATEINTAFYTNILNTSTISSSKFMTADKVIPVIRLAEVHLARAEAIFEQTLEIEATALSDLNAIRTRAGLPALQESDFGGDAFAFYDSLVLEKNREFMYEGILFHDLKRRATYLDDLDMANSDPLDDKFILPIPQAETDTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E100</accession>
    <name>A0A654E100_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB</name>
        <name evidence="4" type="ORF">MARINOS108_140016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16013" checksum="B05B10512ECF7C02" modified="2020-04-22" version="1">MSKKIAIGGDHAGYYHKEKLVKWLQSEGYEVTDFGPFNADSADYPDFVHPACEAIEKSDCEFGILICGSGQGVTITANKHQKIRAALCWDTDLAAVTRQHNNSNVVCIAARWTAYELAESIVKTFLTTEFEGGRHQRRVDKISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E158</accession>
    <name>A0A654E158_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_140024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="33774" checksum="0148B4B560794E41" modified="2020-04-22" version="1">MARIPSPIGQIHDPLFEEKGLEVWIKRDDLIHPHIMGNKWRKLKYNLLHVRESHLAGIVTFGGAYSNHIAATAAACAANQLPSIGIIRGDELSPDSNPTLRFASDQGMKLQFVSRNEYRQLKENQHQLQQIHPGYLILPEGGTNELAIRGCQEIWTEINQSFDYVITSVGTGGTMAGLLKAMSGEGKLIGISALKGNFIHSEFRNMLQHHNIPFENYELMDQWHFGGYGKVTDDLVAFINDTKEKINVLFDPIYTAKMYFAVTKLIETNYFPSNSKIVLIHTGGLQGIAGFIEKQKKNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E177</accession>
    <name>A0A654E177_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6063" checksum="F9561C4D916E70AB" modified="2020-04-22" version="1">MAWESLYLEWSKRSVASYGYVGVFISGLIPRVFGGYKIRKAELISYEDNQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E192</accession>
    <name>A0A654E192_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="472" mass="49407" checksum="3906EF75F4B56631" modified="2020-04-22" version="1">MSNSMSLNTSSLYEKRWAALAVLCTAQFMVIMDTSIIGVALPAIQSALNYTPSGLQWIFNAYVIVLGGMLLLGGKLSDLYGSKNVFLWGFGVLTLASLLTGMAWSETSMNVGRALQGLGSALIAPAALNLLMSIFTDPKELGKAFGFWGAAAAAGGSAGVFLGGVLTEYMSWRWVFFINIPLGILVMLLGVSLLTNGSKLRGKIDYLSALLVTAATMLIVYTLVMVEQNGWTSLTTIGLFAIALALLILFIVIQKRSKSPLLPLSIFKAPNLSAANLVMALMAGAWIPMWFYLNLYLQQTLGYTAFWSGVALLPMTIAIMILMVGVSGKMIERFGMKNNLVAGLSVLTASLVWFSTVSVDGNFLVDVLGASLLGAVGMSLAYIPGTMAAMSGAKPEETGLASGLVNTTYQVGSAIGLAIVVAVAIAITNGLAPDGEVTTESLTAGFQGAFRTAAVIGVLGTLVALVGIKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B9</accession>
    <name>A0A654E1B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="265"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="385" mass="44716" checksum="32DC1837ACC5D010" modified="2020-04-22" version="1">MSLLQVLLFASCIQALLLAGYFLFYSSLRGIRLFGLLLIVMALHLYLVANDNQAFFLRFPHLLHITWVIPALYGPLILIFVRRITRLGVHFSKVEVIYFLPFLLLVTYHFPFFMSSASAKSLYIADFERSVVDDFGLINQAVAWLHVAYFGTALWYLKAYQLKILDFAANEEARLLWLGHFLRFALIVVAIGILAFYSKKFDWPMLRHLYPYHFLGLLALIYWCAFCLIRQPVIFQSPDEEDLFISNQKAPGKSKVQETNVELAEQLKHLMEEEKLYKTPGLTLADLATLLQTNKQYISETINQTFGKNFYDFVNEYRLQEFLFLSDNPDYHHLKLLGLAYEAGFNSKATFNAVFKKHYETTPSNYLRSKVVEKESELINSDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R8</accession>
    <name>A0A654E1R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="681" mass="76132" checksum="76E9E1377F4FC908" modified="2020-04-22" version="1">MDNSWYSFDVSPVWVFASLITALGVAVLLYARKTAPWSKSWNIFLGFLRLSAVFLILLLLINPLLQFNVNKTDTPLVIIAVDNSESIGLRSEAATPSEVVNWINNVQRELENSYTPMAETLSGRQDTILFDQKTTNLGALLKKVENVYKEQNIGAVVLLSDGIINEGRSPAYQTYGFPVFTIGLGDTIPPKDIAIRNVRNNQVAYQGNQFPISILLSQKGYDGLPLPVEIIENGRKIAAQEITLQPNAQEVNFQLDANSPGIRRLTIAVGEKEGESSYVNNQQDVYIDIIEGKDKILILAPAPHPDINAIRSVLNATTNYESVLFIPGIHERPKEKKFDAIVEHQAFSGHQYGDFEATGKWYIMGNSSNVRNMAQTITYLSINLKGNGKDKVRGAYNQNFTKFKISEDLTDRIQNYPPIEVPFGEYQLVGPTEVLLYQKIGSINTERPLLVFFDDGAQKSAVTPGAGIWQWRLQEAGSEENSQLFEELILKTVQYLSIKVNKDRFVVKPRESNYHIGERVFMDAEVYNEIYERAYGNTIQLVITDESGNQTSYEMVDSPVNSSFNLGALEAGVYQFKATTTLGGKGFSETGSFAIRDIQLEGINLTADHNMLRAVAEKNDGRFYPFSQASQVSEDLIGKGYKNIIKTSKETFPLINSIWVVLLITGLLGTEWFLRKYLGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V6</accession>
    <name>A0A654E1V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025461">
        <property type="entry name" value="ABA4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14108">
        <property type="entry name" value="DUF4281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16414" checksum="858E4D26790F519B" modified="2020-04-22" version="1">MDSNTLFDLTSAIAACAWALMIFTPRWKYTQRAIQTIAIPGVLSVFYLGIVITHFSTGLPDFSSLREIRVLFSNDYMLLAGWIHYLSFDLVIGSWILTKSQAQGFSHWLVAPVLLLTFMMGPVGLLAFFILYYLKIREWPLITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X5</accession>
    <name>A0A654E1X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="8017" checksum="EC323A520BBB3D8C" modified="2020-04-22" version="1">MTKKKSEDDHKPKVNKELEGFDIRIDPFGEIKSTIDIDKINQFLNKSVDDKKLRDRDDLEELKKGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E221</accession>
    <name>A0A654E221_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025071212" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1633" mass="184080" checksum="B2C6D13EB8DA46D9" modified="2020-04-22" version="1">MKRLGLFVLIGMALLSEVQAQRSFSDDKATFFNQVMTRLRALDTEPARKVAFDFNNAWTGAFTSANQDMIHSIALQMDKKGYGFDPFFWYYFSYLAFANAQANLPSSDIAQVLKINDQMVKTMNREEYRNFLLGLNMFMARRIIGKSKNVLALTDNGTFQFKLLDEYIEPVEQIEEPIEEKEPLNPPDNKGSLWSGPQNDDWNSGQNDPWADDADPWGDQKDDPWADDADPWADDGKSSYDDNWVDSENVWGYDDSGEVFEEKADRQFVETIAQDYVAGLQAKYRHPALEGPAIQLENNSMLIVTPYDSMRIKETDGTFLLKNRVYAGENAVINWPADNKNFKGAVVNLGKFYIRADRADFWSPNATLTFPKLFQGSVSGAYEFKSQTRKPNQLSNFPKFTSNESNIDLILPMTNVRYRGGIEISGNRLSGASVSRRLGKLTLLDGKGNQAILRSERFEFRADSVITSASARLTIKHGSDSLIHPSVEVFYDTKTRKLALLRTKEYNVTPFVSSYFQVNVNAQIINWDMKTDSINFSILNGKDLIPVTIESRDFFSQERFSRLSAGFQFHPVITSVFYANKFNTREFADREIANHFNVPLKQVRGAMKLLKQFGFAKYNPETGLVQLNDKAFHYHDASGQKVDYDNLLIPSLSPNLPNATWRLDSGDMKVTGVSRFYYTSDFKVYAEPKDQVMTLLKGRNIEMDGMVNAGDFQYKGKHYLFDYDQFLINLQQVDSIRIQVELPDSLKQAGQEKVSLQNHLNETSGTLYLDDPRNKSGLKSSAAFPDFVSESDAIVYFDGPEVLNGAYDKSVKFIIPPFDSDSLSSQEAIRFDGTFNSGGIFPNFEETLSLQPDQSLGFIHQIPPEGYTLYGTTARTYENIRLSNQGMRGKGKIDFITSTIYSKDFVYYPDSVAAYGTGGVIRPGEANGSSYPEAVLGPYRMHWEPRIDSMFLRNIRKPFKFYNATAELDGAVNITSRGVYGVGTMLTRGSRAVSQELTFKEFSYSARHAKFAILTNNPDKPAMAGDDIRLNFDLKNGTALIQPEKAGVAALSFPYAQMRTSITNAVWNLDDSTVTMTKPKNVPIASSYFYTTRKDLDSLAFNAEQATYDFNSRELNVKGIPYIIVADAKIIPENNETTILENFELQSFNNAELIIDTLNAYHYLYNGEVKIISRNKFIGSAMYRLVSGADTFAIKFDQFVLSEVFVDGKPKLMTTSGGEVLAKENLIIAPGFYYKGAAKMFAYKKALELNGAVKLMLSDPAYDYWILFERKDNNPEIAIDVETALYDNEDPVVAGLQYDLRGSLYSTFLADKKNDSDEDFFKAKGILTYDTASLSYRIEKPSKTLGESYDGHTLIYDDKTKNIIFEGPVSFFSPYAQKVTIEASVLGNGNATSNEYNIDAFLAITLQNSQTFMELMSEDLLDIIERLGPPLANDISLELLYKLANFTSDKVAKAYEKASLKDYKPLYTSAENLEKSLVISGVKMKWSQAHKSFYNTTKLAISNIYDNDVNAKLDGFIEIKKDDSNNDAMNIFIQAAPGTWYFISYASNNLLMYSSNSKFNDEVTAKSNYGKSKPGELVLVLGDENETLSFINDFREKYFGITDPYDLVSPDEVNLDDETFDTIEESDDDGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E233</accession>
    <name>A0A654E233_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Death on curing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018297">
        <property type="entry name" value="Doc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="14747" checksum="9BE60940109270F3" modified="2020-04-22" version="1">MSSPSEFRWVSEPVVHAIHNEQISRHGGLPGIRDNALLESALARPKNVFAYENGSITQCAASYMYGIVRNHPFLDGNKRTGFVVGVTFLILNQHYVEVSEADVVMEILNLANGNTSEEALELWLRRIIVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E255</accession>
    <name>A0A654E255_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">atpA</name>
        <name evidence="13" type="ORF">MARINOS108_140117</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="12">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="151"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="11">
        <location>
            <begin position="396"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="525" mass="56514" checksum="223F1CC4311DEB2F" modified="2020-04-22" version="1">MADVRPDEVSAILREQLSHSKTEAELEEIGTVLQVGDGVARIYGLTKAQAGELLEFNNGLRAMVLNLEADNVGAVLLGESSGVKEGDTVKRTGRIASIQVGDGMSGRVVDTLGNPIDGKGAIQGELFEMPLERKAPGVIYREPVSEPLQTGIKAIDAMIPVGRGQRELIIGDRQTGKTAVAIDTIINQKEFYDRGETVYCIYVAIGQKASTVAGIQAALEKAGAMAYTTIVSAAASDPAPMQFFAPFAGAAIGEYFRDTGRPALVVYDDLSKQAVSYREVSLLLRRPPGREAYPGDVFYLHSRLLERAAKVINNDAIAAQMNDLPESLKGKVKGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETNLFNSGIRPAINVGISVSRVGGNAQIKSMKKVAGTLKLDQAQFRELEAFAKFGSDLDASTKRTIDRGRRNQEILKQAQYSPSPVEEQIAIIYASTKGFLDKVPEDKVKAFEKEFLTILNNAHRPVLDALKAGKWEDSSTDVLAQVAKDLAARYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C5</accession>
    <name>A0A654E2C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="192"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="455" mass="50346" checksum="2E9EF7B675A6D7A1" modified="2020-04-22" version="1">MDAIQHFQSNKERYLEELLDLLRIPSVSADSKFKGDVRKAAEFIKAKFEEAGADTVELVETPGHPIVYAEKIIDPKLPTVLVYGHYDVQPADPYELWDSPPFEPVIKNERIYARGACDDKGQMYMHVKAFESLVKSGSLPCNAKFMIEGEEEVGSSHLETFVKENKKKLAADVILISDTSIISNDTPSITVGLRGLSYLEVEVTGPNRDLHSGVYGGAVANPINVLCDMIASLQDKEGHITIPGFYDKVEDLSTEQRSEMAKAPFDLEAYKKDLKINDVKGEKGYSTIERTGIRPTLDVNGIWGGYIGEGAKTVLPSKANAKISMRLVPHQDSDEITEIFTKHFESIAPKSVKVKVTPHHGGEPAVISTTSPAYQAASRAFEEAWGKKPIPTREGGSIPIVALFQKELALDPILMGFGLDSDAIHSPNESYGLFNFYKGIETISHFYRFFSELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M3</accession>
    <name>A0A654E2M3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">ftsH</name>
        <name evidence="10" type="ORF">MARINOS108_120528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="220"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="639"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="698" mass="77798" checksum="C2F9FAC0257C0BB2" modified="2020-04-22" version="1">MGGKPNKPNYQLLIIVGLITVVFGFTYFSRSNTTVSISDKRFEQMVLANDVKKVVLIKNQDEVEVTLKPEALQNTKYKIELEEQSPFSTNSGPHYKFKIVDPTIFNQKFNELMDKLPKDQQIGYEVDERQDFTTFIFNWGFLFLIIFGFWFLMRRMTGGGGPGGQIFNIGKSKAALFDAENKVKITFNDAAGLEEAKEEIKEIVDFLQNPGKFTTLGGKIPKGALLVGPPGTGKTLLAKAVAGEAGVPFFTLSGSDFVEMFVGVGAARVRDLFKQAKEKAPCIVFIDEIDAIGRSRGKGQMPGSNDERENTLNSLLVEMDGFSTDSGVIILAATNRPDVLDSALLRPGRFDRQISIDKPDIIGREAIFKVHLKPIKQHENVDAKKLAAQTPGFAGAEIANVCNEAALIAARRDKKAVDMADFQDAIDRVIGGLEKKNKIISPEEKKIVAYHEAGHAVAGWFLEHADPLVKVSIVPRGVAALGYAQYLPKEQFLYQTEQLMDEMCMALGGRVAEDLVFGKISTGALSDLERITKLAYSIVTVYGMNDKIGNVSFYDSKQSEYNFTKPYSDATAELIDKEVKSLIDQAYARTKELLKEKGKELEIIAKELLEKEIIFQGDLDRLIGKRPFENQTTYERFTNNKNVNDERDEQEALEKLEAEKAKQEELAKLKSNVIQEVQKEDGAVDTETEEELEDKKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P4</accession>
    <name>A0A654E2P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="13538" checksum="1899C9A32AA208D4" modified="2020-04-22" version="1">MKTIINSPKAPAPIGPYSQAVLSNSVLYVSGQIPIDQATGQLVSTSIEDETRQVMKNLSYILEAAGATFANVLKCSIFIKDMGQFAQINAVYGEYFPENPPARETVEVSRLPKDVSVEISCIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S4</accession>
    <name>A0A654E2S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="27785" checksum="8733A3835C26A21B" modified="2020-04-22" version="1">MTHLTDEDLVAYLEGDRSPEREDHLRKCDTCQSRIKEMEELLFLMETTRELDPPASIAWNVAEAIREERNEGSPSRNIPFWQIAAAVALLVVGFAVGQWSVTDHRDEVIALRSQVDLLKEVSMINALQTSTASQRLQVVSRIEEEKSEASDQLVATLMKTLNTDESPNVRYAAAQALARFTDQEQVRLELSKSLEYQSDPLIQIALISILMEAQERNAVRPLKKLLDAEGTSPEVKQQAKVALEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W1</accession>
    <name>A0A654E2W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012683">
        <property type="entry name" value="CHP02302_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13779">
        <property type="entry name" value="DUF4175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1124" mass="130016" checksum="BE09DF76901F90C3" modified="2020-04-22" version="1">MSVDLLKNNLDRFKRKYFVNKILKGSLVSGVLFGSILLIISLLEGYFWFSETIRLMLFSLFVLLIGYCLLFQVLAPLLSLVRLRKGISDHQAAHEIGRYFPEIQDKLVNYLQLSELSNSESSLLAAALHQKTNELTIFSFKEAINFRVNLKYFYYLSAVAVFILLVSFINPNLFIDSTTRIIHFNQPYEKPAPFTFHVLSDLVGFQNDNYELKVALKGNSLPEEVYLVENGRRFRMSANGEELKFNFPALSKDKQFRLEAAGYFSPRYEIKVYPRPEIRDLNIQIKYPKYTGLSDQKTSNVGSLIVPEGSQLHFTLKSSDADKVFFITESDSTSMTSTGDQTYALSRTALNSFNYELALRNNHARNKSKIAYEIAVTKDQAPEIEANFFPDTVTYQSLLITGSIMDDYGFNQLNLHYKRANADSYRRIPISYDRSLNSQQFIYQWNFDSLQLEDREYLTVYVSVGDNDAINGTKFGYSARFTLRMPSNEEIKSLIESKSENSQNELEKSLQNSEALNKQLKELESRLKNKKEIGWQDQKMLEQLIRDKKKLEKDIEELKLKHQQLLESQKEFGKQSKKLQEKSEQLQNLINEVLDEETKKLYDELQKLLKEESNSEEVLKQLSKIQNKEQNLEKELERALELFKRMKLETQLEQAAQELKELGEKQEKLGEKTQSKPSDENAESLNEQEEINKAFEEIQKDLEEAEELNEELKSPEPLDDLNKDREEISEKLDEIKDQLSPDEPSESEEENEQGERPENEQNNKERMNSTGQKMKNAGQKMKAAAQKLEDMQAGAEMVMMQENLDNLRDILDNLIKLSFEQERILKDIQEVEQVDPRFIELSQEQLKLMANIEVIEDSLLSLASRVAQISNFVTREVSEINRNLETAMFELRERNKGKATSNQQYAMTSMNNLALLLDDVLSQMQMSMAEAMGKPQSKGQQKQSMPSMSEMQKQLSEQIQQLKQSGKSGRQLSEELARLAAEQEQLRQAMEEMQKNLAGQPGKEGEDGKDGIGNKLKEAIQKMEENETDLVNKRITQQLINRQQDIITRMLEAEESMREQQKSPEREGETASDITRNIPPAVEEYLKARRQEIDLLKTIPLDLNPFYKKEVNDYFRRLSGQQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W2</accession>
    <name>A0A654E2W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="18060" checksum="CA4EC35B14199E3C" modified="2020-04-22" version="1">MEQLTFENVWGEKSPALIEEISNKWKSLGVIPPNESPEKRARQVVFLIRNEKRGIVGISTAYNLRVEQLGNHLLAFRSLLDPQYRIPGLFIKLVHSSFDYLESIHHTLEPKPIGLIAEIESPNLLKLRDAVTSTGFVFIGYSARKLPLRVRYFKGAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W8</accession>
    <name>A0A654E2W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="354" mass="39421" checksum="72B0295F3A095F44" modified="2020-04-22" version="1">MKEQHDVNKVYDVIIVGGGQSGLALAYYLRRTGLRYVILDAGTASGGSWQNYWSSITLFSPAQWSSLPGTLMPGGTEHYPGKGDITDYLTSYEKRYELKIDRPVRVTEINWHQDIFTLQTSVGTYQARVVVGATGSFENPFIPEISGRETFTGKIIHSAQYRESTVFKNQKVGIVGEGNSGAQILSEVSRVADTFWITKDPPDFLPDHVDGRYLFDAASQLFEAKKRGREYIPPSLGHIVMVPSVKDARSRSVLVHYPSITRFTTNGVELEDHRELPLDSVIFCTGFRPALQIFKNLPVTFRHDKIPTNGTRSRELPGLWMVGYGSWTGFASATVVGVGRSAKATSIEIEEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X5</accession>
    <name>A0A654E2X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="128"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="29190" checksum="F38101F48A65A405" modified="2020-04-22" version="1">MPFKIAILGTGNVGYHLARRLKEVDHEASMVIGRDAEKARSMVETLSLNSAYTSETNFSETPFDFVLLAVPDKAIEEVISRYRFHKNTVIIHTSGAQPLDLLKGVAHCGVLYPFQTFTKNKPVDFEQIPLLIEGNSEQSVSKILELATLFGHDIHQVNSAKRLKIHLAAVFASNFTNYLYTIADDILKDTGLQLSDLNHLMQETVEKAIELNPRMAQTGPAIRHDEEVIQKHLNLLERHPDYKTIYTIISEQIGLLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E303</accession>
    <name>A0A654E303_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21888" checksum="13303C85B7AE82FE" modified="2020-04-22" version="1">MEPFEYVVVLFSLILGLGIAQLLTGIADIVSNLRNTKTGLAHSVMVFNVFLLHIQEWWYSYQYASDVKVWTLPLVLFLLIYPILLFLLARMLFPTGLRGHETNLEEYYYDQWKWFFGIILSIIVVSFLQNIIVSGWAITSQIPQYLMALAYIIFLTLDIHNKKAHNIFVILQGLAWLIWAIVDPYELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E315</accession>
    <name>A0A654E315_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024880541" evidence="2">
        <location>
            <begin position="28"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="179"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="282"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="51149" checksum="CC8ECB7C864291F8" modified="2020-04-22" version="1">MMNQRNNICLKYIAISIALILPLITNAQTEGVVVDKIIAKVDNYIILKSDLEKAYLDYLSRGEFRGSTAKCNILEQLVVNKMLVAKAEIDSVEVADEEVRSNLGRRMEYMISQIGSREEIEAYYKKSMDQIEADLFDDIKEQMVIQRMQQDITADLKVSPAEVKRFFGKIPQDSLPFFSTEVTVGQIVKQPKAGTKQKEDVKKLMYEIRGRVLQGESFAALARQYSEDPGSAARGGELPFYKRGDLAPEFEATAMTLKEGELSMPIETQFGYHLIELQQKRGNTFKTRHILISPKPSSEDVIKARTYLDSLRTAIVNDSITFQAAAKEYSDDQLTSSNGGFFLDDNESNRVSVDQLDPTIFFTLDTMKIGSITKPLEFQQPDGSTAFRILYYKNRLAPHQANLKDDYQKIAAATLNNKRNKILSEWFDDARDEVYIDIDPEFDHCNLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E357</accession>
    <name>A0A654E357_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027471">
        <property type="entry name" value="YbeD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117991">
        <property type="entry name" value="SSF117991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="86" mass="9821" checksum="A0693B854940B984" modified="2020-04-22" version="1">MSWDVESFREKVELQHNFPGYYTFKFIVPVDKKREILDLIPPGEISFKESSGKNYISITAKTKLETSQAVLDVYIAANEVEGCFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M5</accession>
    <name>A0A654E3M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="99" mass="11063" checksum="A7F10DF58DEF3F98" modified="2020-04-22" version="1">MRVSNSDITHIKKTAKSIYGNSCEVYLFGSRVSNDTKGGDLDLLIRTNDPTQLLTKKLTFKARVKQLIGDQKIDVIVRSASAPDEQDHIYQEALKGQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N0</accession>
    <name>A0A654E3N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025045299" evidence="2">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="23994" checksum="7601FA171D07A81A" modified="2020-04-22" version="1">MKTNTALLLVLMAVLFTACGSTKQAMDCPQVYKKKDRIKSQHLTLRSFKKTRKVAKAPQKIQPNQELINAPDNHYPETVSLYGFTTSPTDLITYRYKPYEYEVFELDKEESAEKTLIGDDSPPQKVTSKDELKSAKKDIKEVKNITNSNTKGMARASLILGILSLFIAGIPLGTLAAIFGSISMSKLEYGNGRGMAIAGFIIGLVGIFGALFFLITMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N1</accession>
    <name>A0A654E3N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024816221" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="3">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1152" mass="128233" checksum="7DB459E2C38DD566" modified="2020-04-22" version="1">MRKLVCLSILLVLTTLHAQSQAVARLDTRDARERVPSDSDSVKDVLFKIEKTFEVFFNYDDDLLNQITLQEEVTIPESKADLDVFLGKLFSNYDLEYEKLTDTTYIIYRKTRKSSRSAPDKEDNPEEEQSIRETQDIKKGLGRIDRKGTTLEGKVTDENGETLPGATIIVKGTNDGTITDIDGNFKLDIAGSTFPVVLAISFVGYKSQEIAVTAESFIKVTLSADIAALDEIVVVGYGEQKRSNLTGSISSVKVKDLENKPIIRLDQALQGMSSGVFVSKGGGAPGASPTIHIRGVGSINNTDPLWIVDGIKMSPGNHFNLDDVESIEILKDAASAAIYGAEAAHGVILVTTKRGKEGQTQISYKSSFAKVNPIRLPELLGSEDFVNYKRQARLNAGQNPEPAWDNWEYDTDWIDAYYAGSGFSHYHDFSISKGTERSNYYLSLGYDDEEGILIDNSFQRFSLRFNSDFELAKWLKIGESILLSRVGENPIDNFNEDYQGSIPYRSIPIMPIYDESNPYGGWGRAPVYFQGPNPVASQYQQHEKQVNNRLDGNMYIQATPLKGLTIRARVGYNYTSFLGRAFKEAFDYGAFANPINSLTYSDGNYENITGNFVTTYEKSFGKHSFKIMGGYEASKVENVSYNVTATDLPLDIAWSFNLATGTFNTTNRQTLYESRLLSQFGRINYNFDDRYLLEANVRRDASAPIFGPKNIWGIFPSYSAAWRISEESFMQNVDVLSNLKVRASTGRLGSDNIGSFIYAKTYTSQFSTYAYDAAAQNKQSGFYISKFPNADVKWEEVNMHNIGLDVGLFDDKILLSADYYIKDTKDLLYAVPIPSSSGISTHNFDARNPEINVGTMRNSGLDLDLAYRDHFGVFNLKVNGNTSFMKNEVLRLNGDEYITSGNGGGQIGGMTRTQAGMPISSFYGYVVQQMLNSEADVYAVNSWAPDGIYQEAGTGPGDFMYKDISGPNGVPDGQITAEYDRTFIGNPWPKMMYGLNITGGYKQLIDVMLQFQGVHDVDIFNANKAYTRNFFGDNNTTTDIFEAWTAEAHTSHPRNIANDPNGNFGRPSTYFIEDGSYLKLRNAQIGINMPPQMLEKMGIGKIRVYVNANNLLTIRKYSGMDPEIAGSNVSRGVDYGLYPHTRTFGGGLEVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q5</accession>
    <name>A0A654E3Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14118" checksum="2B7FA03F6199F307" modified="2020-04-22" version="1">MGINSQGLRTTIYKVDDLAEARSWYERAFGVSPYFDQPFYVGFDIGGYELGLLPEKVEGIRTENVLTYWAVEDITDAYDKMVSHGAKELETPNDVGEGIKVALVKDPWLNVIGLIYNPFFKQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E456</accession>
    <name>A0A654E456_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cbs</name>
        <name evidence="13" type="ORF">MARINOS108_120272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="343"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD16506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="457" mass="50502" checksum="5177293034811611" modified="2020-04-22" version="1">MRYYNTLIETIGNTPLVKLNRVNKGIKGTILVKVEYFNPGNSVKDRIALKMIEDAEKSGQLKPGGTIIEGTSGNTGMGLALVAQAKGYKCIFTLADKQSQEKMDILRAVGAEVIVCPTNVSPDDPRSYYSVAKKLNEDIPNSIYPNQYDNPSNTLAHYESTGPEIWNDTDGKITHYAAGMGTGGTICGTSKYLKEQKKEVVSVAIDSYGSVFKKYKETGIFDEKEIYPYLTEGIGEDILPKNVDFDMIDHIVKVTDKDGAVMARRLAREEGLFCGWSCGSAVHGALEFARDHLKEDDVMVILLPDHGTRYLGKVYNDNWMKDHGFLETRKFATAKDIISSRNGSSGLKTIDKNLKVGEAILTMNQYGIDQVPVVDGDEFVGSLNDTHVLKSLLQNPDIKNQPVSDIMDSPFQFVGMDNTIDVLSSLIQKENKALLVRDHQNVVHIVTQSDLLMAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A9</accession>
    <name>A0A654E4A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="18748" checksum="E2B3C5285211ACB6" modified="2020-04-22" version="1">MKRHTINILLVAILGVVALSCGNKELESRIAKLEGKIAELESKGSPARPAANPAPEAAEPEVKPEGPLPAIEFAEEDHDFGTIKEGEIVEHMFKFKNTGDAPLIISSATASCGCTVPVWPKEPIAVGEEAEIQVRFNSKGKPGIQNKTVTITANTYPKINRVKIKANVTKEANPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E0</accession>
    <name>A0A654E4E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_60048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="974" mass="108309" checksum="236D0FF46E460582" modified="2020-04-22" version="1">MNFDLLEKQLEGELFTDETTRKLYATDASAYREIPLAVAIPESDADIVALIRFANEHGTSVIPRTAGTSLAGQVVGGGIVVDVSKHFNQILEINEKEGWARVQPGIVRDDLNAALKPYGYFFAPETSTANRAMIGGMIGNNSCGSNSIVYGSTREHLMEVNTILADGSQAWFGPLDMNAFLARCNGMSTSGELEASIYFQIKEMLSDQENLGAIKEGFPKASVPRRNTGYAIDMLAEMVPFKENGAVFNFSKLIAGSEGTLAFVTSAKIKLTPIAPPHKRLVCIHCHTIDESLRANLVALKHQPTACELMDHYVLEATKRNITYRDYRFFVEGDPQAILVAELTHDSEEAADVAAAALIKDLQDAGYGYSFPVIAGEDIKKVWGLRKAGLGLLSNVAGDAKPAPVIEDTAVDVQDLPEYIAEFNEILARHDLFCVHYAHAGSGELHLRPIIDLKTADGRRLFRTIAEEIATLVKKYKGSLSGEHGDGRLRGEFIPQMVGEHNYELIKKVKQTWDPKNILNPGKIVNTPPMDTSLRYEENQVTREFETVLDFSDTEGYLRAAEQCNGSGDCRKTELSGGTMCPSYMATRNEKETTRARANILREMLTRSEEANPFAHEEIKEVMDLCLSCKGCKSECPSNVDMGKLKQEWQYQYYKEKGVPFRSRLIGNFAGGMKLASWVPWGYRFTFGNQVTSTLAKSVMGFAQKRSMPKLSKQTWERWFKKEFKPTVSEPIKQVYLFIDELLNYNEAEIGITTVKLLDKLGYEVVYIEHQESGRSFLSKGLLDKAKSLARANVDLFKNLIDEETPLIGVEPSAILTFRDEYPDLLRGEDKEAAKAIAANTFMVEEFLAKELEAGHIDLSLFREQKQLIKLHGHCQQKALSSLTPVKKILTKMGSNEVHLIPSGCCGMAGSFGYEKEHYDLSMQIGELVLFPTVRKQPEEVIIAAAGTSCRHQVKDGTGRVAKHPVEIIWEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I7</accession>
    <name>A0A654E4I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_60108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031317">
        <property type="term" value="C:tripartite ATP-independent periplasmic transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026289">
        <property type="entry name" value="SBP_TakP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039026">
        <property type="entry name" value="SiaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="2 3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039026-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR039026-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="374" mass="42064" checksum="D14A2E792A6229A4" modified="2020-04-22" version="1">MTSKKGNKDRRDFVKKIGGSMAMVGTIGLAACTPEEKKSININFNNTYRWKMTTTWPPNFPVVGEGCKMMAEWVRKMSGGRMEITVYGGGELIPALEGFDAVSNGAVEMNHGAAYYWAGKLPAAPFFTCVPFGMNAQQMGSWIISGGGQKLWDELYAPFDLKPFICGNTGVQMGGWFNKEVNSLESLKGLKMRMPGLGGKVFAKAGGTPMLVSGGEIYTNLERGVIDATEWIGPYHDYKMGLHQVAKYYYYPGWHEPGPVLEMIVNNTKYQALPEDLQEIIITACYRLNRWMMSEFDAKNGEYLLKILEEKKVDVRPFPDEVMQGLKEATKEVLEELTASDPMSKKVYEHYSAFRKQIKPWMDISEKVFYDQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P6</accession>
    <name>A0A654E4P6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplS</name>
        <name evidence="7" type="ORF">MARINOS108_20821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="13237" checksum="44DED7A2915DFE2C" modified="2020-04-22" version="1">MSDLIKFVEEENKAAKANHPAFSAGDTVNVHYKIKEGNKERIQQFQGTVLQIRNVGSTGETFTVRKISSGIGVERIFPILSPNIDKIELVRKGKVRRARLFYLRGRKGKAARIKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V9</accession>
    <name>A0A654E4V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pnp</name>
        <name evidence="8" type="ORF">MARINOS108_90063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="632"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="714" mass="77909" checksum="45894A9123712209" modified="2020-04-22" version="1">MKPQYTVKKFALADGREISIETGRLAKQADGSVVVRMGDAMILATVVSKKEAGEGVDFLPLSVDYQEKFAAAGKIPGGFLKRESRLSDYEVLICRLVDRALRPLFPSTYHADTQVMLSLISADPEVMPDALAALAASAALAVSDIPFDGPISEARVIKLGDEFLVNPTPAQMAEASLDLIVAGSADNIMMVEGESKEVSEEDMLEGIKVAHEAIKIQCQAQVELAAEVGATVKREFDHEPSDAELEAKIRAHCYDACYEIAKKGSANKTERSEGFDAIKESFLATYTEEEREELNSFLVKKYFHDVQKDAVRNCVLDTKKRLDGRDLDQIRPIWSEVDCLPSAHGSAIFTRGETQSLTTVTLGSKMDEQMIDGAMISGYNKFILHYNFPGFSTGEVRPNRGPGRREVGHGNLAMRALKPMIPTEDNPYTIRIVSDILESNGSSSMATVCAGALALMDAGIKIKSPVSGIAMGMISDSATGRYAVLSDILGDEDHLGDMDFKVTGTEKGITACQMDIKIDGLSYDVLKEALSQANRGRLHILNEMKKTISEPRAEMKENAPRLVQLVIERDMIGAVIGPGGKIIQEIQRESGATVNIEETDKGGLVSVFAADKGALDNALSRIKAIVQVPEVGEIYEGKVKAIMPFGAFVEVLPGKDGLLHISEIKWDRVDNVEDVLEVGEEIKVKLIEIDKKTGKYRLSRKVLLPKPERKEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y2</accession>
    <name>A0A654E4Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6114" checksum="CB0FFF08B9BA9C2A" modified="2020-04-22" version="1">MLCDALNIARMRMANRNDRMTTIQIKVSDASCVVDIAAFTSGDLYRKEWIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E576</accession>
    <name>A0A654E576_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hemolytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12990" checksum="DC9FBFED8FD84F25" modified="2020-04-22" version="1">MCHLLHGQDEQRDFELVLEKLSIREAPAHQRSFFLFHFYQKHLSNQILNDCIYDQSCSEFSKLSFAGYGLFKGLFLTADRLTRCNRATFAETSPALINLQGKVIDHWDDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A0</accession>
    <name>A0A654E5A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formimidoylglutamase</fullName>
            <ecNumber evidence="3">3.5.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formiminoglutamase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Formiminoglutamate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hutG</name>
        <name evidence="5" type="ORF">MARINOS108_50078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:22492"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="EC" id="3.5.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.8" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050415">
        <property type="term" value="F:formimidoylglutamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00737">
        <property type="entry name" value="Formimidoylglutam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005923">
        <property type="entry name" value="HutG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01227">
        <property type="entry name" value="hutG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="36786" checksum="4402D5D273E75C8A" modified="2020-04-22" version="1">MYQSPNKKIWTGRNDPFDGEDGHLWHHVVEVVDMEKNLVPAAHPNQVAILGFASDEGVKRNQGRPGAKDGPDVIRKAMCNLAVHFNNDELMIKDVGNVVTVKSKLEEAQKELSEKVTTLLGAGYFPILLGGGHEIAYGHYNGIYEFVKDKPKRNIGVINFDAHFDFRSYANGAHSGSPFRQIVDDCEERGEQIHYLPIGINQAANQRAQFKVMEIYNQTYIPLEEVRIDTIEEIKMRILGFAARMDYIYITLDLDVMSMGFSPGVSAPAAFGVFPYLVRGMIKTILGTGKVISFDVAEFNPTYDDGRTAKLAASFVYDVAMSRKKKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D5</accession>
    <name>A0A654E5D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YvlC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yvlC</name>
        <name evidence="8" type="ORF">MARINOS108_20844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="65" mass="7314" checksum="F36D9C5B802840CA" modified="2020-04-22" version="1">MEMTKRLYRSKKDSMLAGVCGGIAEYFDLDPTLVRIGYLVLSALSVGFPGILVYIILWIVVPEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5E2</accession>
    <name>A0A654E5E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6825" checksum="FF1D659A69AA3DB5" modified="2020-04-22" version="1">MLTTKSRKDVHPLYKYMQHWQAFNQLMRKQVNHSLLRGLGYLIFALIILGLLEYWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5E3</accession>
    <name>A0A654E5E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016828">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025414">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024839172" evidence="5">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="358" mass="40010" checksum="D344AACAA073522E" modified="2020-04-22" version="1">MQMLRAVLVHLVGILLFGLTACAEEGSPKIDKNPPKEEPTVDSLFLNPVHTSGPDPWVFQKDDHYYLTFTTGINVTLYKTDVMSDLSKAYQRVVWTPPASGPNSRNIWAPEIHFIRDKWYIYYAADDGNNDNHRMFVLENSSADPTVGQWVDKGELKLPGDRWAIDGTIFEHADQLYYLWSGWSGATNGRQDLYICKMTDPYTAEGDRVLLTKPELSWETNGTNPTVVEGPQVLKNGDKLFMIYSAGGCWTDGYSLGMLTAAADADLMTAESWVKSPNPVFSQNPSGNAFGPGHNGFFKSLDGTEDWIIYHANPFEGQGCGGARSIRIQPFTWDQQGYPDFGTPHPLYQKLTRPSGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5E5</accession>
    <name>A0A654E5E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane receptor proteins, mostly Fe transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="225"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="473"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121021" checksum="06257982792DAF46" modified="2020-04-22" version="1">MNTKVHLFISFMSKLAICTMIFCYSLTMAFAGESLAQRKRLVETHVDVRQNHEELLGLIKELEDVTDFSFMYTRSDLKGKKISIPKGEWNMERLMKDVSSQSKVSIRRVNEIISIKLVLDNTQNPQLYEELISQITVSGRVIDDSGETLPGATVQVKGTSVGTITDVNGLYSIVAEEQDVLVFSFVGFKTMEVPVDSRTEINVELSMDIEALDEVVVVGYGTSKKEELTSSIVQIKSEDFRAGVTNNPVELLKGKVPGLSIINQAGSDPNSTPQVNLRGVGTISANNEPLVIIDGVYGTMPDLYILNPNDIESFNVLKDAASAAIYGTRGSNGVIIVETKFGEREKSQIIYTSSYFIEKPRRNPEMLNAQEYLDVMRTLGFSKESIDKGFDTNWTDELITSKLSSYHSLAISKGTKTSQMRFSLGYRDSKGLILNSSNKTANFRLNFKQQIYKWLEAEGTIGGNRSDQAFANYNALDEALKYDPTAPVYNEDGTFYQLPGVGASNPVALLKQIENGAISNRVNLNVNLTGHITDNLSVSVKGSSFLRNYERSLFEDIDSRNSVLSGIPGRAEKENNSSVENIFEATSNFNQQFGKHNIKLLAGYSLINNVTHGSNMFNRGFLTNKLKYNDIGAGSFLQDGRADFGSFKQSYRLIAFFGRFNYSWSTKYLFNASLRQEGASVFGENNKWGLFPAVSGGWRISQEDFMSDLPFISSLKLRAGYGVTGRSQGIAPYQSLARIGESGRALYNGQWIFTYGPINNPNPDLRWERSKELNIGLDFGVLSERVTGSVDFYTRITDDLLGSFNTQTPPSLEPVLFTNVGSIKNQGIEFIGTFKAIDGNEFKWDITPTFSINTNEVISLANDQFQADTIYYGDYGNVATSLYMMAEGTAVGTFYGFKFKEIGSDGKWVFKDQNNDGRIDENIDYQVIGNGLPKYFFSLNNQFSWRQFDLSIYMVGAAGYHVFNEKRLWYENTANSPSNYFKSMLDEPQSSLDDRLRFSDYYLEKGNYLRLDNITLGYNLKNVSVFKQARIYTTVTNVALLTNYSGIDPEVGSGTNGGLSFGWDTRSFYPRSATYLLGLNITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F6</accession>
    <name>A0A654E5F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ORF">MARINOS108_11157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22382" checksum="1828E423CD842661" modified="2020-04-22" version="1">MNYFVTAIGTDSGKTLVSAILTEMLHADYWKPIQSGAPRDTETVRALVTNEQSKFYKETFLLKTPASPHAAARIDGIEITIDQIVPPISNRDLIIEGAGGVMVPLNDEEVILDMVPKLNAEIVLVSNLYLGSINHTLLTAEVIKSRGYDVKGIIFNGPGNEESERIILLKTGYRQLLKVEQEPVINKEIVKKYAEKLSACWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G0</accession>
    <name>A0A654E5G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_60046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="190"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD20853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="672" mass="78205" checksum="66AD3CC93123CD42" modified="2020-04-22" version="1">MPSKNTPILVKNDPWLAPFESDIQDRMKRFEARKKQLESEYGSIDAFASGYNYLGFNYDTKKKGWWYREWAPNASALSVIGDFNNWDRSAHPLQKNDRGIWEIFLEDKLYGSKLTHEAAVKVHVVSDKGGVDRIPAYARYVTQDEKTYDFTARLWHPEKPYKWTDKKFAPDQSFDNPYIYECHVGMAQEKEGVGTYREFADKILSKIKEQGYNTIQVMAVQEHPYYGSFGYHVSNFFAPSSRFGTPHDLKYLVDTAHKLGIAVIMDIVHSHAVKNLAEGLNEFDGSDDQYFHPGGRGFHTLWDSKLFNYGKEEVLRFLLSNVKYWLEEFHMDGFRYDGVTSMLYFHHGDISFDHYEKYFKDVDWDVLTYFQLANDLIKEIKPKGISIAEDMSGMPGLCRPVSEGGMGFDFRLGMGIPDYWIKLLKHKHDEQWNIHEMWDTLTNRRYGERTIAYAESHDQALVGDKSIAFWLMDKEMYTHMHKDTPSLIIDRGIALHKMIRLFTLSLGGEGWLNFIGNEFGHPEWVDFPREGNGWSYKYARRQWNLQEHPDLRYKQLYNFGAAMVQMANDEKIVGSLPAQQLNMDEDNKAIIFERNNLIFAFNFSPTNSVPDYRFKVPVPGKYKIILNSDKGEFGGHDRIDDEMTYPTVALFGEHFLSVYLPSRVAIVLKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5M2</accession>
    <name>A0A654E5M2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside N(6')-acetyltransferase type 1</fullName>
            <ecNumber evidence="3">2.3.1.82</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aminoglycoside resistance protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B</text>
            <dbReference type="Rhea" id="RHEA:16449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58390"/>
            <dbReference type="ChEBI" id="CHEBI:58549"/>
            <dbReference type="EC" id="2.3.1.82"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.82" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047663">
        <property type="term" value="F:aminoglycoside 6'-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024170">
        <property type="entry name" value="Aminoglycoside_N6-AcTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000452">
        <property type="entry name" value="6-N-acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17724" checksum="F055710BC45F55D4" modified="2020-04-22" version="1">MPKGFDLMEIVRFDHSNIDQLTKMIVELWPECKLDQEYTNCVKAMESERECYFLARAHGQYIAFIYLNLRFDYVEGASSSPVGYIEGIYVKPAFRKQGVAKMLIERAEKWCREKGTSFLGSDTETDNLDSVAFHQKVGFKVTNRLVTFIKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5P6</accession>
    <name>A0A654E5P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="18108" checksum="287510B50E1DF70B" modified="2020-04-22" version="1">MLFPEKLMKTQVEQLLDEYKKVRNIDLTLDQFTYILNLYPSLIVCMCDGVLDKGEWDGVLRLAKGLAMEYGDGLGDPDLERLEQSFRTEFRYLLDNIEKWQKKFLNALKNHISDSRTDKEFVLESMYLFANAADGISDVEQETIEMLTERLSLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E653</accession>
    <name>A0A654E653_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="47" mass="5302" checksum="CAA7E7381BA6063D" modified="2020-04-22" version="1">MLKNMTEGNDAKNTKISLSKKNTNDCAHENQAGQIFLGNVYNHCYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E688</accession>
    <name>A0A654E688_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">MARINOS108_20248</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="6"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="399"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD18480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="621" mass="69386" checksum="AFA8B508A2B40028" modified="2020-04-22" version="1">MFPEYDVIVVGAGHAGCEAAAAAANLGSKVLLATMNMNTIAQMSCNPAMGGVAKGQIVREIDALGGYSGIITDKSMIQFRMLNKSKGPAMWSPRAQSDRMRFAEEWRMALENTQNVDFWQEMISGILVKDNRAIGVRTSLGIEIRSKAVVLTNGTFLNGLIHIGEKQFGGGRAGERKATGITEQLVSLGFESGRMKTGTPPRVDGRSLDYSRMDEQEGDEVPEKFSYLDSTQPLQKQRSCYITYTNPDVHASLQTGFDKSPMFNGRIQGLGPRYCPSIEDKINRFAERDRHQIFVEPEGWDTVEVYVNGFSTSLPEDVQYKALRLIPGFENAKMFRPGYAIEYDFFPPTQLSQTLETKLISNLFFAGQINGTTGYEEAACQGLMAGINAHQKVKEKDPFILSRSQAYIGVLIDDLINKGTNEPYRMFTSRAEYRLLLRQDNADLRLTPLSHQLGLASDHRNQLTANKLQATKQLINNLKQKKFKPLDINPTLADLNMAPIKDTSSLYQLLKRPDIELSTFTAFNQSTKEFVESLDKDIAEQASIQIKYETYIIREQENAEKMSSLDEKKINPDFDYLKISSLSSEAREKLLKIKPTTLGQASRISGVSPSDVSVLMVYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6X8</accession>
    <name>A0A654E6X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="25406" checksum="31241308626FD9AE" modified="2020-04-22" version="1">MIITPDFVWTHMAKTGGYSVHRMISLVGDENIQLDPLGGEWSDYRRHEPFWMRSEKCGYDITANKIKVLTIRRLPAWILSFGEFKKREEGFEFDLQELSKGYFKHEKRDMVSGGLSDPGSYDTHHADEALAYYRPETIDHWWKQESLNEDVVCFLGRFYTLTPLQIKQMSCSHENSNEYDRNLGKRFSQRQLEELYHNCPLWSTYEQKVYGSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E707</accession>
    <name>A0A654E707_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pdxJ</name>
        <name evidence="3" type="ORF">MARINOS108_20518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="26249" checksum="4494DDD6B9F92A64" modified="2020-04-22" version="1">MTKLSVNINKIATLRNARGGNNPDVIQVALDCERFGAQGITVHPRPDERHIRYDDVMQLAKVVKTEFNIEGYPDARYMEIIEKVRPAQATLVPDGPDVLTSNAGWDTIQHQKQLTDMISTIKGWGVRTSVFVDPDIKMVEGAKAIGADRIELYTEPYASGFAEDKAGAIADYVMAAQTAQKLGLGLNAGHDLDLNNLKFLKTNIPFLDEVSIGHALVCDALYYGLENTIQMYLRQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E785</accession>
    <name>A0A654E785_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12601" checksum="1C62FA6B6439A44F" modified="2020-04-22" version="1">MVEINIQAESDYQLIEVRGEVDASSSIELDNALKSAAENYAKILINLSKLEYISSAGLGVFISYLEELKTNDIKLVIFGLQEKVREVFDILGLQHLMNITNNKEEAQALLNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7A6</accession>
    <name>A0A654E7A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025498">
        <property type="entry name" value="DUF4389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14333">
        <property type="entry name" value="DUF4389"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22849" checksum="A2319749F8E5DF08" modified="2020-04-22" version="1">MKLTIQHQEYYSRGELILRSLFGAIYIAFPHLFLLIFVSIWGAILQFIAWWIVLFTGKYPQSFFEFQVGLLQWNLRLNARLMNLSDGYPAFGINASDEYTSLEVPYPENISRGLLLLRAFFGFIYVLIPHGFILYFRTLWGIILSFLAFWAVLFTGKYPESWHTFNVETLRWSTRVSLYMGFMDDQYPPFSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8X1</accession>
    <name>A0A654E8X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045755">
        <property type="entry name" value="FtsL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19579">
        <property type="entry name" value="FtsL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13968" checksum="3010E06C4E7E5EFB" modified="2020-04-22" version="1">MATNTYKIPGKSSGKQGSFFTLLERYLPMDESLAEVIHVRFLPQILFICALCIVYIGSRHYAEKKIRTISRLETQVEDLRADFTTLKADYKYASKQSEVAKQARSLGLVESDVSPYKIIVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E901</accession>
    <name>A0A654E901_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6061" checksum="9B58545DC6865BA8" modified="2020-04-22" version="1">MVEDGWQSGGVGHLLPHIFSTHEDSTNYIVHFILQLSERPRRTNSQANNRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9B8</accession>
    <name>A0A654E9B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">fabH</name>
        <name evidence="10" type="ORF">MARINOS108_120099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="109"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="247"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="335" mass="36939" checksum="281E0B0A87140711" modified="2020-04-22" version="1">MYTSKISGIGHYVPDNVVTNKDLEQYMETSDEWIEERTGIKERRWIDPTTDDMPSTMGTKAAKIAIENAGLTPDDIDFIVFATLSPDYYFPGPGVQVQELLGIREIGALDVRNQCSGFVYGLSVADQFVKTGMYKNVLVIGSEYHSGGLEKSTRGRGVTVIFGDGAGAVVLSRSEDTTKGILSTHLHSEGKHAKELALIGPATNRWVDKIMTENDPEDTSYYPYMNGNFVFKHAVTRFSEVIQEALMTNGFQTSDIDMLIPHQANLRISQFIQKKMGLGDDNVYNNIMRYGNTTAASIPIALSEAHLEGKIKPGDLVCLAAFGSGFTWASALIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9I8</accession>
    <name>A0A654E9I8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fused isobutyryl-CoA mutase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="5">Isobutyryl-CoA mutase</fullName>
                <shortName evidence="5">ICM</shortName>
                <ecNumber evidence="5">5.4.99.13</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">P-loop GTPase</fullName>
                <ecNumber evidence="5">3.6.5.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="5">G-protein chaperone</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">icmF</name>
        <name evidence="7" type="ORF">MARINOS108_120161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-methylpropanoyl-CoA = butanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:13141"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="EC" id="5.4.99.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IcmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.13" evidence="5"/>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047727">
        <property type="term" value="F:isobutyryl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034784">
        <property type="term" value="F:pivalyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02050">
        <property type="entry name" value="IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033669">
        <property type="entry name" value="IcmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4 5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="5">
        <location>
            <begin position="406"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="208"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="345"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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            <position position="760"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="853"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="1005"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1124"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1125" mass="125474" checksum="4DB51C1C0D5E08FC" modified="2020-04-22" version="1">MSQTIAPYKPVNHIRIVTAASLFDGHDAAINIMRRIIQSTGCEVIHLGHNRSVQEIVDCAIQEDAQAIAITSYQGGHVEYFKYMYDLLKERGASQIKIFGGGGGTILPEEIKELHEYGITRIYAPDDGREMGLQGMINDLVKTSDFPVGENLNGQLKKLDKKDVNAIARVISAAENYPEENIGLLDEIRKSMDAKKIAPVLGITGTGGAGKSSLVDELVRRFLLDFEDKNIAVISVDPSKRKTGGALLGDRIRMNSIFSDRVYMRSLATRQSNLALSKYVKDAVDITKAAGFDLIILETSGIGQSDTEITDHSDMALYVMTPEYGAATQLEKIDMLDFADVIALNKFDKRGALDALRDVKKQYKRNHGLWETPDEELPVYGTIASQFNDPGMNQLYRAIIDALSKKTGADLKSGFETTQEMSEKIYIIPPKRTRYLSEISETIRDFNETVEKQKEIAQKLYGLDKSLEVMRAMDKEAAIQAIEEAKSQLELDLDPHNKKLLEEWEAKKANYAGEQFTYEVRGKKIEVETTSETLSHSKIPKVSLPRYEAWGDVLKWSLQENVPGEFPYTAGVFPFKRKGEDPTRMFAGEGGPERTNKRFHYVSHGLPAARLSTAFDSVTLYGEDPDHRPDIYGKIGNSGVSICSLDDAKKLYSGFNLCDPTTSVSMTINGPAATIAAFFMNAAIDQQCELYIKEKGLEQEVEAKIKKIYDQLGSERPTYKGDLPAGHDGLGLMLLGVTGEDVLPREVYEEIKARTLSSVRGTVQADILKEDQAQNTCIFSTEFSLRLMGDVQQYFIDHAVRNFYSVSISGYHIAEAGANPITQLAFTLANGFTFVEYYLSRGMDINKFAPNLSFFFSNGVDAEYAVIGRVARRIWAKAMKIKYGANERSQMLKYHIQTSGRSLHAQEIDFNDIRTTLQALYAIYDNCNSLHTNAYDEAITTPTEHSVRRAMAIQLIINNELGLAKNENPMQGSFITEELTDLVEEAVMVEFDRITERGGVLGAMESMYQRGKIQEESLYYETKKHNGDLPIIGVNTFLSSTGSPTITPDEVIRATEDEKQAQITNLNALHHRNESKSAAALQKLQNVALNNGNTFAQLMESTKYCSLGQITHAMFEVGGQYRRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9K3</accession>
    <name>A0A654E9K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024831196" evidence="1">
        <location>
            <begin position="36"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="303"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="44793" checksum="8DED5A9B303B6480" modified="2020-04-22" version="1">MSIRIDNFITQTHHPKNMKTIASLCSLIVCSFAFAQSPITSIPFELFGDHMLIKVSVDNSEPLDFIFDTGSGLTVIDSDVAEGLKLSGKKIKMNEATTTVELIKHNEIEIDGFPMEKNIKVYATDLDHLEISLGRDIDGIVGYDLMHHHTIRINYENKTMDIYEHGKGPKSGDAVPFVLNTSIPTISGKVVLNNKEPHTGTFFIMSGAGTTLDFNSPYAQKYDVIHKTGKHYSYVVKGITEEETLHYEGHVLSLSFGNQVIKDLPIGISQANHGIQASPEVSGIIGNKILSMYNITIDVPSKMLYFEKNANFGQKLSVNCSGIDLQLTPDKKRVLIHQVFEDSPASDAGIKLNDELITINDKSVAEFDLPDIKDLLKKEGETVNLVIKQDGQEKSVSLTLRSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAW0</accession>
    <name>A0A654EAW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="507" mass="58863" checksum="E6C6A10F3FE1D1D3" modified="2020-04-22" version="1">MEILNSILTWVMKKRIHDIELFMKYPHEVQEELLMSLISRASKTEYGKKYEFDSIATREQFRQRVPIVTYEDIFPYVEKLMRGEQNLLWPTEIRWFAKSSGTTNARSKFIPVSNEALEDCHYKGGKDLLSIYVNNYPDTKMFTGKNLVIGGSQQVNQFDKNAKSYYGDVSAVLIKNLPFWAQMVRTPSLDIALMEEWEEKIEKMAHYTLDENVTSISGVPTWTIVLLERILEIKGASSILEVWPNLETFIHGAVAFTPYEKLFNSLIPSPNMRYMETYNASEGFFGIQDRTDSKEMLLMLDYGIYYEFIPKEEWDSEQPKTISLDEVELGKNYAIIITTNSGLWRYKIGDTIRFTSLDPFRIKISGRTKHFINAFGEELIIENAEEAIAEACEQTDAEMENFTAGPRYLEAGTRGCHEWIIEFNKQPKDLDQFKRILDAKLREINSDYDAKRHKDIALVAPLVHLVAKGTFYHWMKKRGKLGGQNKVPRLSNNREYLDDLLEMIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSR1</accession>
    <name>A0A654DSR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Quercetin 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yhhW</name>
        <name evidence="5" type="ORF">MARINOS108_10134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.24" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008127">
        <property type="term" value="F:quercetin 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="26934" checksum="0C3E3BE2C54A996E" modified="2020-04-22" version="1">MNTIKHTSESRGTAHFGWLQSRHTFSFGRYYNPERVNFGALRVLNDDIVTAGMGFGAHPHDNMEIVSIPLSGDLEHKDSTGNTEVIRTGDVQIMSAGHGLTHSEYNHSKSNEVNFLQIWVLPKERDIEPRYQQITFSPEGRKNQWQTVVAPDNDQVLWINQDSWFSLADLDARMELAYALKKEGNGVYVFVIEGEVTVNGEELKKRDALGITGAEVINFSATKDARLLLIEVPMIESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSU9</accession>
    <name>A0A654DSU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module toxin RelE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="13303" checksum="0E6ACD0073B91DCC" modified="2020-04-22" version="1">MKRFEVSFLEEAVEFLDRLDEKAREKIIYNVKKAQMSNDKELFKKLTNDIWEFRTLFKKTYYRLFAFWDKTGSTETLILTTHGLVKKTGKTPKGEIEHAEQIRKRYFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTJ2</accession>
    <name>A0A654DTJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="19659" checksum="50800A633E9D64C1" modified="2020-04-22" version="1">MASGEHTGPYTGVTTYTRSDPMISKLELITLSIIVLAGCSKPEPVAEYRDGKQFLNLNELNIKGESIEPISLVVIKPDSIKVKEEAIFRIVTSNPNFKLVNGIFDCNISNESLIDTSNFKVDNCKKEFVVRNDTMFIALKPGKTGQFEFGTEIIGITKGIDGILRYHTTTFNYEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTN0</accession>
    <name>A0A654DTN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14751" checksum="1A391B636D2CE722" modified="2020-04-22" version="1">MSLAFGLMTSYNSPPEGNKYQLIIFEGSDWCVNCRRLERSVLSDVDFQVFLEANNISLIRVDFPQRNKLTAAQKNQNDSIARRYDFRGVYPTIVLVEPTDQAYLELGYMNETSSDFARRIDLGLKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTV6</accession>
    <name>A0A654DTV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="150"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="253"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="407" mass="45024" checksum="974A313632D84E83" modified="2020-04-22" version="1">MSTDTLTPNGQATKRNFKDEFESPDFYQIDDLLTEEHKLIRSSIRDFVKKEITPYIEDWTEKNHFPSEMVRKFGEIGAFGPTVPETYGGGGLDYISYGLIMQEIERGDSGMRSTASVQGSLVMHPIYAYGSEEQKKKYLPKLASGEMLGCFGLTEPNHGSNPSGMETHFKDMGDHYLLNGAKMWISNAPQADIAVVWAKNEDGRIKGLIVERGMEGFSTPETHGKWSLRASCTGELVFSDVKVPKENMLPGKDGLGAPMGCLDKARYGIAWGAIGAAMDCYESARRYAAERIQFGKPIGSFQLIQKKLSEMLTEITKAQLLNWKLGKMMDEGKATTAQISLAKRNNVAVALEIAREARQIHGGMGITGEYPMMRHMMNLESVVTYEGTHDIHLLILGAEITGIPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU52</accession>
    <name>A0A654DU52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23422" checksum="5A3AC170877EF5F4" modified="2020-04-22" version="1">MSKISVIVVDDHQLFREGVRSLFAEDDLISIEGEADSAESMYSFFDQALPEVVLMDITMPGADGLSIIRESRKRFPDVKFIVLTMHADGQYVVKAVRSGAFGYLLKNADKEELSEAILTVSKGKKYFNSEISQLMVGNISLEGDNTQRLSERETQVLQLVSNGKTTKEIAEELFVSSRTVETHRVNMMKKLDVQNTAELIKKAVKLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUB3</accession>
    <name>A0A654DUB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="109" mass="12239" checksum="97521CAADC7DA4CD" modified="2020-04-22" version="1">MNGYQYIDGGTFDNFPVKPILNKCEKIIGINISPVNEIEELKSLSAIAARVFQLSVNATAHNSLRECDLLIEPKELFKYTILDSSAANEVYQIGYEATKKELEENPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUG9</accession>
    <name>A0A654DUG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Outer membrane beta-barrel porin/alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="30590" checksum="4043B0CEB6CCFBCF" modified="2020-04-22" version="1">MNQKKHILASILLSISLQTIAGGGWVYQKNKGFLKLGQNMIRSQYFFNSGGNITDIPTVSLYTTSFYGEYGLSDRFNAILYVPFFVRSTLNRVEFNQSGNTIPGDEINSFGDTNIGLKYGMFQDQPVHLAASLILGLPFGSSEVSSDRILQTGDGEFNQLLKLEASHSISGTPAYITGILGFNNRTQGFSDEFHYGGEIGVSLNQFTTLLKVYSVNSLYNGDADTSNANGVFANNTEYMSFTPELIYSVDNGLGFAASAGFASSGKRILAAPNFGIGVFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUH2</accession>
    <name>A0A654DUH2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mnmA</name>
        <name evidence="8" type="ORF">MARINOS108_10668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="7">
        <location>
            <begin position="106"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="42495" checksum="C15B21CF822DAC02" modified="2020-04-22" version="1">MSKHGRILVAMSGGIDSSLAAVMLHEEGYEVIGMTMKTWDYQTSGGSKKETGCCSLDSINDARNIAVSLGFPHYIVDIREEFGDYVINHFTSEYLEGRTPNPCVLCNTHIKWDSLLRRADKLDCEFIATGHYANVRHENDRYVISKGKDEHKDQSYALWGISQESLSRTKYPLGHLHKSQIREMATERGFHELVSKSESYEICFVPDNDYRGFLKRRVNGLEEQVKGGEFVLEDGTVVGTHEGFPFYTVGQRKGLGIALGYPVYVTEIQKDTNRVVLGTFDELSRDGMYVKNLTMQKYASIEGERKDTVTKVRYNDNGTPAVIEQIGDTMKVYFGNGVKAIAPGQAAVFYEGNDVIGGGWIKSSFRQENPMGMPAISNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUH8</accession>
    <name>A0A654DUH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="526" mass="59775" checksum="AED9EFFA23591168" modified="2020-04-22" version="1">MIFKSSYLFLVVCLLFGGCQQHTSQTERPNIVLVMVDDMGYSDIGCFGGEIHTPNIDQLAASGMKFTNFYNNGICVPSRTSLLTGVYPQKAGIYTNRPGKYQNSITFAEALKPAGYRTLMVGKWHADETPFQRGFDRHFGLTDGAANHFNPGPGRLNEPEPGRKLTTVPRGYPRRWAIDDQEYLPYETVKPNFYSTDTFTDYALSYLEEYKNEPDPFLLYIAYTAPHYPLQAWPEDIEKYKTRYKSGWDSLRQERFERLKALNLVEDHLVLGDRDEEVEPWEQVEDKDEWVSKMAVYAAMIDRVDQNVGRVLDKLEALGERENTLIIFLSDNGGCAEDANYTPDIAPGPVESYRSVGAGWANASNTPYRRFKRWNHEGGIKTPLIVNWPGVVASGSTTDRVGHLIDFMPTFLELANAQYPDQFNEKPILPIDGKSLVPVLKGAPDSGHELLFWQSNPKEHRAVRQGNWKLVSQGDEFETELYDLASDPLEQSNLALQNPQKLKELDSLFQSWASQVNIGDQEYIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUI4</accession>
    <name>A0A654DUI4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">menA</name>
        <name evidence="7" type="ORF">MARINOS108_10383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="32929" checksum="4CE6569729894F15" modified="2020-04-22" version="1">MKKIKAWIQAFRFRTLPLAFSCIFMGAFLAASNGFFNWPILIWSLVTTLFLQVLSNLANDYGDATSGVDGEHRTGPKRTVSAGLISQSAMKKALIVFSLLSLCSGLWLIFLSFGDRWTEIIVFLVLGLGAIVAAIKYTVGKRPYGYAGFGDLFVLIFFGLVGVGGSYYLYAHTLNLLILLPALSCGLLAVGVLNVNNIRDIESDKLAGKHSIPVRIGRVNAIVYHWILLSLAMVSSCVYVSIVNPRGFSFLFLVVLPMLFSNARAVKIKKTSEGLDPFLKQLALTTLIFVILFGIGQVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ2</accession>
    <name>A0A654DUJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tail-specific protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020992">
        <property type="entry name" value="Tail_Prtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040573">
        <property type="entry name" value="TSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11818">
        <property type="entry name" value="DUF3340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17804">
        <property type="entry name" value="TSP_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="243"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="591"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="688" mass="78266" checksum="94FC7358E32A329C" modified="2020-04-22" version="1">MNNLLLILLLVLSLGFSDGSEHLVQTSSQDQLVSDSLKVLEPKPEHSSETFVIINLLNRYHYRKATLNDSLSSVVFDNYFESLDPNKSYFLKGDLDYFEKYRYRIDNDLPEGNLDFAYQVFSIYRERSLDRMDYVHELLKTEPDFDQKEYFETDREALPWPENKIEQNEVWAKIIKSQALSYKLAGKEWKDIAEALGKRYKRVEKALYQYNSEDVYQAYMNALTSAYDPHTDYFSPIAKENFQIDMSLSLEGIGAQLTQQLDYTKIADIIPGGPAYKSQRLQKDDKIIGVAQGDDAEFVDVVGWRLDEVVQKIRGPKGSVVRLQVIKHNKDINGLPDTIRLVRDKIKLEKSAAKAEIIPITEGNQTFSLGVINIPSFYLNFEEMNSGVKDYRSTTRDVKKLIDSLNQKGVDGLMIDLRYNGGGSLQEAIELTGLFIPKGPVVQVRNTDNSVDIMEDEDNGKVYYDGPLAVLTNRYSASASEIFSGAIQDYKRGIIVGENTFGKGTVQNLIDIGRYMRQSDVELGQLKMTLAKFYRVTGSSTQKLGVAPDIAFPSPYDDEIFGESGRPNALPWDEISSSNFKMTNQISPKLISKLEALYQNHLEEDKDLQDLVKEIERAKELRKQTAVSLNLEERRLLQQEDEEIEDNLSTTLDQGEVFTDENAKKLSEDPYLKEGLRLLAELSKIKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW9</accession>
    <name>A0A654DUW9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">bipA</name>
        <name evidence="4" type="ORF">MARINOS108_10796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="9"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="599" mass="67008" checksum="1A8316F8ACDA1C33" modified="2020-04-22" version="1">MRSFRQRMTNIRNIAIIAHVDHGKTTLVDKIIYAAQANDSKRSQDNNELILDSNDLERERGITILSKNVSINYKGTKINIIDTPGHADFGGEVERVLSMADGVLLLVDAFEGAMPQTRFVLGKALGLGLKPIVVVNKVDKENCRPDEVHEEVFDLMFNLDATEDQLDFPTLYGSSKHGWMSHDWKNPTDNLEPLLDTILKEIPAPEQKEGVLRMKITSLDFSAFTGRIAIGRIHQGSIKVGQSLGLTKSDDTIKRVRIKELHVFEGLGKRSVEEVGCGDICAVTGIESFDIGDTITDFDNPEPLERVGVDEPTMNMLFTINNSPFFGKEGKFVTSRHLRDRLMKEIEKNLALRVESTDSEDKFLVYGRGVLHLSVLIETMRREGYELQVGQPQVIYKEIDGQKHEPIEHLVIDVPEDVSGKAIELVTKRKGELTIMEPKGDIQHLEFNIPARGLIGLRNQVLTATAGEAVMTHRFNGYEPYKGEIPERLNGSLVSMETGPGTAYAIDKLQDRGIFFVAPGDELYVGQVIGEHSRANDLAVNVQKGKQLTNMRKSGTDASMKIAPPKKFSLEEALEYINKDEYVEVTPLSLRMRKINFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY2</accession>
    <name>A0A654DUY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytTR family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="26596" checksum="778483D64E78433C" modified="2020-04-22" version="1">MKRKFNILIVEDELMIAEMTREMLLDLKYSVVGIAKDHDSAIDYLTKSEDIDLVILDINLGRKKTGIDIAEVIQDQYEIPFIYLTSYSDPKTIKKAAQTSPAAYLLKPFIKSDLYTTIEIIIARNLKSEGTILIKDGDLNVKLKTRDIHYIMSDNNYLEVFTLRKKYIVRNSLDGFLEELNDSNFIRIHRSYAANILKIEAVNGQYVLVGEAKLPLSRTHKQEVIDLFMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV09</accession>
    <name>A0A654DV09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="12123" checksum="398AC971A689AA8D" modified="2020-04-22" version="1">MNDSSIGSLEETILLIVLVMQEDVYGVSVVEEYEKRTGKTISIPAIHTVLSRLEKKGFVSSQMGGATSERGGRKKRIFEITRTGYKILAELKATRDELWEMAPQFNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV11</accession>
    <name>A0A654DV11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12743" checksum="DD15FFCE77CFDCC5" modified="2020-04-22" version="1">MVSPEDFQKMALEFPETEELPHFEKTSFRVNKKIFATLDLTHLQASLKLSIAEQDIFSLGQAGVIYPVPNKWGKQGWTIVVLRKIDKTLLRAVLTSAYCQVAPARLSKGITRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV48</accession>
    <name>A0A654DV48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046111">
        <property type="entry name" value="DUF6048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19515">
        <property type="entry name" value="DUF6048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024814785" evidence="1">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="26265" checksum="AF231ABE81A1262C" modified="2020-04-22" version="1">MRPLLYISSFLLMWQAFAQADSVAVDSLEEESVRFIQPSFSFDYGKALVSAAGFEQKYEGAFSLLFFENYYLTGEIGTGNLQPKNGIENGKYQSEGNYYRIGGGYLKAINSTSRLGLGVRYAMSTFNDLGEYYVESQSGSQDDYSEQFIRKNLEARWVEMVLTSESKVRLKKSVPEARINQLFSLGFHLRLRVMSSYDRFSPIDVYSVPGYGRTVNNPNLALNLFLKFTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVB1</accession>
    <name>A0A654DVB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding universal stress UspA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="152"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="34315" checksum="22F0D052D7FD595A" modified="2020-04-22" version="1">MYKYNKILVGLDHTETDLDLVKAASDVCELSGSKVVYFVNIIKDINLPEKLMKEFPHILDQAIEERKNNLQKTVTDHFKFEGAEVVVNVIVDQGQVTKTLLKHASAEKIDLVILGRKNEKKGGGVLVNRIARRAGCSLLILPKGSQFSVSSVLVPTDFSAYSRSAMEKATMLVKKSKKPGKIIVQNVYQVPVGYHYTGKSFKEFSEIMKDHAKNDFAKFTKSMKLDGVNIEQIYTLDKDEDIISDIYKAAKKIKASLIVIGAKGRTATTALFIGSKAEKLIHVDEEIPMLVVRPKGKNAGIIEYIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR2</accession>
    <name>A0A654DVR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024861326" evidence="1">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="13914" checksum="FEA7B0B52C0E04A5" modified="2020-04-22" version="1">MNILKKTGTITSLLAIYLLAIGLACSAQAHLLVQKQGTAAYYQSDQLSDQFKHTFPPTYNVIIQGTSSPRPYPTNESQTWAVLWAHSFHFDRPFNGLYYHVLNLLIEQEKTDLLYPFHFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR3</accession>
    <name>A0A654DVR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-2-hydroxyglutarate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lhgD</name>
        <name evidence="2" type="ORF">MARINOS108_11077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="44548" checksum="6BF66C9A999846F3" modified="2020-04-22" version="1">MYNVVVIGGGIVGLASALKIKESNPKLRVAVVEKEKGLATHQTGHNSGVIHSGLYYKPGSLKAKNCVDGYHKLIKFCDEEEIPYELCGKIVVATNEEQITTLNMLYERGIQNGLTGMKKLNKEELNDYEPHVNGIEGIHVPQTGIIDYKAVAAKYAEKIRHFGGDIFPDNKVLDIQENKGFIQVITQHQTLTARLVINCSGLFSDKVAKLTGVPVNYRIIPFRGEYFKLKKEKEHLVKNLIYPVPDPNFPFLGVHFTRMIGGGIEAGPNAVLAYRREGYTKSDINLGELAGTLGWKGFRKVAGKYWKTGLGEFYRSYSKSAFTKALQELLPEIQKNDLEPGGSGVRAQACDREGGLIDDFLILESDKVINVGNAPSPAATSSLAIGEHVAGLALKRFEKVTVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW9</accession>
    <name>A0A654DVW9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mro</name>
        <name evidence="9" type="ORF">MARINOS108_11199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024920747" description="Aldose 1-epimerase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="376" mass="41364" checksum="29911BF0899C174A" modified="2020-04-22" version="1">MKNRNILFLALIILGFACAQQEAPKATLTSAPFGTLPNGDSVTLFTLTNVNGLSMDVMTYGGIVTALRVPDRDGKLEDVVLGYDNLDGYLKSSPYFGALIGRYGNRIADGRFTLDSVEYTLVQNNGKNHLHGGTVGFDKVNWTATSVDVEGGVALALSYVSADGEEGYPGTLTTQVIYTLTNENEWKVSYEATTDKRTVVNLTQHTYFNLSSMKEDILNHELVLNAPAFLPVDSTLIPTGELRPVADTPFDFTSGKPIGRDILKDNTQLNYGLGFDHCWVLEKSDKKMNFAASVYEPVSGRFMEIYTEEPAIQFYSGNFLDGSITGKNSTVYNHRNGLCLETQHYPDSPNQPEFPSVVLSPGETYRTSTVMKFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ6</accession>
    <name>A0A654DVZ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14291" checksum="EEF27A04A194BE2F" modified="2020-04-22" version="1">MQQLVQLALVVADYDEAIAFYTQTLRFELIEDTKMSETKRWVVVAPPGNTGCRLLLAKGVGDEQLSRVGNQTGGRVFLFIHTDDFEGDYENLKAKGVKIVRGPVDEPYGQVLVFEDLYGNLIDLIQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW48</accession>
    <name>A0A654DW48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024937269" evidence="1">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M61_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M61" evidence="2">
        <location>
            <begin position="290"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="509" mass="57366" checksum="A0380BEB6C7E4849" modified="2020-04-22" version="1">MKKIIILCGALAVSTLAMAQDLPVMSYEIDISQNLDTFFVTLSPATTLDKSARIYQFAATAPGTYQTMNLGRFVSSFRAFDKKGRELLVTRKSVNQFEISKPHKIAKITYQIAETFDTPVEDFPVYLMCGSSIEEDHALINAHTIMGYFEGYQKRPLSISVTGKDDWKIGTALPMEGHRFLASSFDHAVDSPILMGELSFADTTIADTQVEIYTYSQQGKFESKSLLAGMSDMLDATLQFLVKLPVDRYTFLYFFEPGLTGATGAWEHSYSSEYVLEEKDPTPEYMQSVTDIASHEFFHIVTPLNIHSEIVESFNFVSPTPSVHLWMYEGVTEWASNMLLYRGGVIEEEDYLQNAIATKILVDEKYFDPTWSLKKLSDESFNGGAASKEYANIYFRGSLVAGLLDIRLLELSGGQAGLRELMLKLIDQYGKGKPVSEKTFFDDLTAMTYPEIRDFFDQYILAANPLPHEEYLAKIGLELTRGEAGISVTKMKEMSEDQRKLFEAWSKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWC4</accession>
    <name>A0A654DWC4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">murB</name>
        <name evidence="18" type="ORF">MARINOS108_11359</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VXD13302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="37706" checksum="190C1280DBC6A276" modified="2020-04-22" version="1">MLIEENFSLKDHNTFRLDVRANFKAGITQPEELQELYANPKFKTVKKLVLGGGSNVLFTRNFLGLVLKMEIGGIAVEQDSADSVIVSFGAGENWHQCVLWAVEHGYAGIENLSLIPGTVGAAPMQNIGAYGVELKEVFHSLDAYDVKTGKISRFYNEDCKFGYRYSVFKGPRKDKYIITRVYLRLSKKPKFNITYGNLKETLEQMGVEELTLKNVSQAVINIRQSKLPDPLEIGNAGSFFKNPVVEKVYFDSLKAAFEEIPGYEVDEGSVKLPAAWLIDQCGWKGTRIGDIGVHDKQALVLVNHGNGKGKDILKLSMEIQKSVFSTFGVELEREVNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK0</accession>
    <name>A0A654DWK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">MARINOS108_11429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="72"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="34769" checksum="DD13B97532572599" modified="2020-04-22" version="1">MVLLSIWRISQDFSLSERGAILILCEHPLAGRGKFISFIGTCREQGAFLRAGCSQLKQNEMSITKESELIGMLKISEVVGTTLKLMREYAKVGMSTKELDEYGGEILKSYGAKSAPYETYGFPGYSCISVNEEAAHGIPSEKKILQEGDLINIDVSAELNGFWSDNGGSFILGKDIHHHQPLVDASRNILRKAIGHIKGGVKISEIGYLIETEAKKSGFKVIKNLAGHGVGRSLHEEPENILNYRVRTNRERFRKNTTVAIETFISTKSTVAVELNDGWTLVGNKGGYVTQHEQTILVTDNHPVILTESNEIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM6</accession>
    <name>A0A654DWM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin RelE3</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">relE</name>
        <name evidence="1" type="ORF">MARINOS108_11482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9513" checksum="1C95A3128F7770D4" modified="2020-04-22" version="1">MFSFSKDLDKIKKPKDLKSVAEIIELVKSAKSFEEVIGVKKLTGFEDAFRIRSGDYRIGVFVNGNTVEFARVAHRKDIYQIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX27</accession>
    <name>A0A654DX27_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="17127" checksum="7CFF238DB6F0271D" modified="2020-04-22" version="1">MEIKPYQETDREQLLDVWEKSVLATHHFLSPEDFISIKAMVREIDFSRFEVHCLMDESRVIGFLGVAEKKVEMLFLDPHYFGQGLGKKLINFAIVQLKAHKVDVNEQNVGAVAFYENLGFATYERSDKDDQGNDYPILRMKLRTRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX29</accession>
    <name>A0A654DX29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mercuric transport protein MerT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mercury ion transport protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MARINOS108_11599</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MerT family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015097">
        <property type="term" value="F:mercury ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003457">
        <property type="entry name" value="Transprt_MerT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02411">
        <property type="entry name" value="MerT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0475">Mercuric resistance</keyword>
    <keyword evidence="11" id="KW-0476">Mercury</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="145"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="23533" checksum="D4604058CBB17F05" modified="2020-04-22" version="1">MSTTNHASRQTSLSSKSAGAGLFAAIVASLCCITPVFSLLAGIGGIAATFSWMEPFRPYLIALTIGVLGFAWYQKLKPRTKEKIECACETDEKPSFWQSKKFLGIVTAFAALMLAFPSYSRMFYSNGSSPNTSVILSQDTTKTHKIVLDVKGMTCAGCEAHIEHEVRSLPGIKSVDAIYTEGSATIEYLPSRLEEKTIIEAINQTGYTVIEKPKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX36</accession>
    <name>A0A654DX36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <ecNumber evidence="10">1.17.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dapB</name>
        <name evidence="10" type="ORF">MARINOS108_10944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="9">
        <location>
            <begin position="106"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="26809" checksum="AA99547075EA6054" modified="2020-04-22" version="1">MRIALIGYGKMGKSIEQIARTRGHQISYIIDQDNHSDIQKISPDNTDIAIEFSQPSSAFDNITTLLSNKVKTMAGTTGWLDRYDEVKALCTETNGTFLYASNYSVGVNLFFELNEWLAKKMSQLEDFVPEMVEIHHTEKKDAPSGTAITLAEGIQKNDPSVKKWVNESSEDHHTLGIISKREANVPGTHTVTYRSPLETIEITHVAHDRKVFAEGVIKVAEWATNQTGILSIRGFLNNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE9</accession>
    <name>A0A654DXE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PilJ/NarX-like methyl-accepting chemotaxis transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029095">
        <property type="entry name" value="NarX-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13675">
        <property type="entry name" value="PilJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PilJ" evidence="7">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="34366" checksum="23B978EBB59462C2" modified="2020-04-22" version="1">MKKYTSKYLSVLGILTLVILGSQILMQQTISGSESDSRIINISGRQRMLSQKITKASLKLKAAENEREFSVAKTELREAYELWVQSHHDLQFGSKEINIIEMNGNEDLTILFKDIEPHFQTIKEASGILIGMRYEDMSNPDKFSIIRQSITEITATEATFLNLMNQITFQYDKQAHAKITKLSTTEYYLLGCTLILILLEIFFIFRPILMDAKRKESLISELSILRADEQSFSSEQIGLANRRIKELRKVALQLKEELTEKHKAYTLKTTDQMMENLRLKAALEEYQATSKKTSSFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI7</accession>
    <name>A0A654DXI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25929" checksum="C8934A8E2F39F952" modified="2020-04-22" version="1">MNILLVEDERSLGESIITYLSKEGYHCEWAENFSKASEKTWAYSYDCVIVDITLPDGNGLDVIEGLKKLKSLSGIIIISARNSIEDRIKGLDIGADDYITKPFDLSELNARVKAVIRRRNFDAQNEIVFKEITVKPYDRSVIIHEQFVSLTKKEFDLLVFFISNQNRVITKESIAEHLWGDDMDMADSYDFIYSHLKNLRKKIQEHGGNDYIETVYGIGYKFTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW4</accession>
    <name>A0A654DXW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008354">
        <property type="entry name" value="Glc-Fru_OxRdtase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01775">
        <property type="entry name" value="GLFROXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="41400" checksum="6EAFFA4A3F2BFB36" modified="2020-04-22" version="1">MKRRHFLSNTAKSTGSIMVASSLTTLGLLSGPSGRAGEKRGLGVALVGLGGYATGQLAPALERTENCYLAGIVTGTPSKADSWVDQYLIPSKNVYNYDNFDEISNNDEIDIVYVVLPNSMHAEFVIRAAQAGKHVICEKPMATKYEDCQRMIDACRKAEKKLSIGYRLHFEPHNLEVMRLGQRQVFGKVLESDAGFAFPLRDKSRWRLDKEMAGGGPLMDVGIYAIQSTIYTLGQLPIALQATDTTVDKAFYGAVEGTLDVKFDFPTGINAKMRTSYEESSNYLKVQAQEGNWELAPAYSYGGLKGRTHLGAMNFPAVNQQALQMDDFATCILKDKQSTVRGEMGQRDMFIIDKIYESAAAGKPVSLKGIPNILHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX4</accession>
    <name>A0A654DXX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="412" mass="44403" checksum="FA299EDBEF9C9CC6" modified="2020-04-22" version="1">MGKIKTFMKSILPGLFLVGLNIGTGSVTAMSNAGADYGLDLLWTIAISCYITYFLIKVFGRFTIVTGETALHSFKEYIHPVFAGFFVVALTINVCGSIMGVIGVISDVCYHWSLSYTPGGVPAIYFAVFFIGVVYLIFLVGKSSMMERIMGILVALMSLAFLANLLILSPSAGQVLSGLIPQIPGTVSPGGQTPYLVVASMVGTTVFSGLFIIRTVLVRDSGWTLKDLKVQNRDAAISSLIMFIISFSIMAAAATGLHQSGLRLENTSQMLSLLEPLAGSFAVVFFVIGIVAAGVSSQLPNVLLPLMMISDYKNQDKLNLKKTSARLVVLILSIFGLVVPLFNARPIILMVLSQAFGALLLPFTVAAMLFLGNKKRLMGEYSFGLISNVQMVLILFFALFISVNSLMEMFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY25</accession>
    <name>A0A654DY25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="317" mass="35031" checksum="26CE3390E257257A" modified="2020-04-22" version="1">MQADSLAQATKKMAQEIKSEMKAPVEHITEKVDSWMDGFLSMLPNMAVALVLFIIFLICAKAFQKVFLKLFRKSSENQALENLFGTIVYYIVLGTGIFIILGVLQLDKAVTSLLAGVGVVGLALGFAFQDIAANFVSGIILAFRTPFRIGDIVKIGDYMGAVSRTNLRVSVIRTFQGQEVYIPNKDVLQSPIENFTILGERRIDLAVGVSYGDDLEKVEQLVRETISNLEGVVRKEDLIFTYTAFGDSSINFEVKFWILYPDQPGYLTMLSKAIKAIKSAFDQNDITIPFPIRTLDFGIKGGEKLSAMQLNTGNAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY84</accession>
    <name>A0A654DY84_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-threonine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ilvA</name>
        <name evidence="13" type="ORF">MARINOS108_12009</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011820">
        <property type="entry name" value="IlvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02079">
        <property type="entry name" value="THD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="340"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD14535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="423" mass="47016" checksum="C661590F54964505" modified="2020-04-22" version="1">MTTNTTHTAFYPEVEEVKKAHNILSKVIYQTALQYSFNLSERYDAHIYLKREDTQIVRSYKIRGAYNKITSLAPDQLINGVVCASAGNHAQGVAFSCYKLGVKGVIFMPAPTPKQKVQQVKMFGKDKVEVILAGDTFDDAYQTAMEYCTVNKSTFVHPFDDPKVIEGQATIGLELFKDANFSIDYLFLPVGGGGLSAGVSSIIKALSPHTQMIGVEPAGAPAMHEAFQQGHVVTLEEIDKFVDGAAVKRVGELTYPLCKANLDEIALVDEGKLCSSLISMYNESGIVLEPAGALSVAVLDQYKDQIKGKNIICLLSGSNNDITRTEEIRERSLLHEDLMHYFIIRFPQRAGALKEFVAEVLGPDDDIVHFEYTKKTSREKGPALVGIELKAKEDFEPLLTRMKQRNFFGEYLNEKPDLFSYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC8</accession>
    <name>A0A654DYC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="20012" checksum="347492611C428CC3" modified="2020-04-22" version="1">MDLTKHCQLCERQLYDIQSGTKCGLTNERPNFSGKCPDIKFETKYEDKIKEINIEYELVKRTKVISIGNFIFFITISIAVIVGGYLLGTYAFDKGVISTVPLIIMGTGVLILPLASGPLNKYRWGMKIARNKKNELDELLANYNIQYSIEVIVNKDLHGNQDITTNLTFQRKHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF6</accession>
    <name>A0A654DYF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="31471" checksum="4D216BB2985C5D6F" modified="2020-04-22" version="1">MKIDSHQHFWHYHPVKGAWITDEMRVIRRNFMPADLEPLLKAEGINGCVAVQADQSEHENWFLLNLAKANPWIKGVVGWLDLKSATLEDQVVLCSEHDSFRGVRHILQAEPDGFMTDPEFIKGVSLLGAKGLTYDILITENQLEEAMRFVKALPEMPLVIDHIGKPNIAASSFEHWAKYMKQMSAFDHVYVKLSGMITEANWETWTPEDLKPYVDFCLEHFGPERLMYGSDWPVCLVAGTYAQVVSALKKMLSHLSEDEQAAIYGNTASKFYKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ4</accession>
    <name>A0A654DYJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045619">
        <property type="entry name" value="DUF6443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20041">
        <property type="entry name" value="DUF6443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6443" evidence="2">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_3" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129713" checksum="D1EA747D177B1E1C" modified="2020-04-22" version="1">MNLRTILLTLTGIVLSHFSYSQTSDENYVTTHRARISGYTGSIAGVTDQTKVMRSTQYYDGLGRPMQQVIRKGSPNSKDLVTPIAYDTYGRQDKGYLMYENAHATPGNYHSSWSTEIASFYSSTTNKVADESTYYYSETKFEASPLNRPSKQYGAGDGWRSPDKFVAMNYSPNTPGTDTRHILQRFSVANNSNQTITHESAYSAGDLWVTETTDENGNISLEFRDKLGQTVAKKSQVSGNTYATTYYLYDVYGQLTFVLQPEGTVQMGTTYSLLNDTAFRKKWMFRYQYDGRRRMIEKQVPGAEPVYMVYDARDRLVLTQDGNQRVQLVNSNISLDKYSGQSYQLNGGTVTLTPGFHAGGSSTNTFSISTTAYNQYTFTKYDVLNRPIMTGICTITDDLVDIRADAQAMSGGETITTTGHGYSTSTTYPNESRSSITFDQVLSVTYYDDYRFKGQGYFGNHTHNYIDKGADFENTAMSAVSGQVTGNKVKVLGTDDYLYATSYYDDRYRMIQSISTNIHGGTDRVSNAYSFTGTVKKSIRNHDGEESVDTEETYTYDHMDRLITATHKIDQQGAVTMQSNSYNEIGELVEKNIGNAVQSIDYRYNIRGWLTTINGGTTLDDGNDRLGLELQYDLAGQFNGNIGKMKWKTAGLGNAYPKTYDFTYDLQNRLKTATYSQLGANNFFNVTGDDNGIRYDANGNIKDLIRTMAGQVADDLAYAYNGNQLVSVKDYGTSGLFTDGNTTNTDYKYDQNGNMISDANKAIGSITYNYLNLPERVSYTDGNGVQEVQYTYDASGVKLKKETTSGADIDYLGGIQYRDGLLDFIQHSEGRARKSGASFLYEYNLTDHLGNVRVTVDAGGNVIQRDDYYPFGLTFNSYTSGTENLYKYNGKEEQKETGWLDYGARMYQPDLGRWFNIDPLAEETYDLTPYHYVYNNPLLFIDPDGMFGDYFDEDGKHLGNDGKDDDKVYEVKGNTDLDQWGPDGPVVNESETTITEIGTRDDFVDMNGKEISSDETKNALVGLSINMKNNGITEDYAKITVTGGDRSETKNKSVSGAKKSRHIQGDAADIKVKGMSNKDLAKAAGNSGLFSASIYYPNMGDTQGFGRHSHTISIGVFNIRTSRRNIQKNAPHVHVDNRPGKPQKAIEYTGHNPKNPTFKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM3</accession>
    <name>A0A654DYM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="183"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="293"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="630"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="806" mass="91150" checksum="D138752B9C4E7938" modified="2020-04-22" version="1">MKRQLARPIIGGVLYFLLIGSVLSQSFSDRKTNINQGWSYLENPEINVEKARNMDGWVLVDLPHTWNNLDATDLEPGYRRSASWYRKVLSFAPEKGSRYFLYFEGANNVTKVYVNGTKSGEHIGGYVGFEIEITGQLIAGKNEILVRVDNGYHPQLIPSHQSDFFIFGGITRDVWLKKTAESYLQDVTIQTPEVSAKSGSTRIVVETQSTGSTKGLEVKVEVKNPAGEIVFSKQADVQAGQAEMSFTLKDPELWGVKNPVLYTAEIQLLRGKRVVDTVEETYGYRWYEFKEHGPFFLNGERLILRGTHRHEEYAGYGAAMPNALHRQDIEDIKAMGANFVRLGHYPQDPEVYKACDELGILVWDELPWCRGGVGDEVWKENTKRLLTEMIDQNYNHPSVILWSLGNEIYWLPEFEDGDNPEKINAFLRELNDLAHALDPYRKTAVRKYYEGADIVDVFSPSIWSGWYSGTYKNYQHAIDNSLKKYPHFVHMEYGGSSHLGRHTESPVTGDGLINANEWEEPINQVQIANIAQNGDWSENYIVDLFDWHLRVSETHPDFAGNAQWAFRDFGTPLRPENDIPYINQKGLVDRAGNPKDAYYVFKSYWSEEPFAYIESHTWTERSGPAGVARNISVFSNADSVELFISGQSLGMKTRDITQFPACGLNWDVLFPAGDSEFRAVAYIGGKSVAEDTLTVNYTYEKSGIPEALELSYKLLENGNYLITATAVDSKQGRCLDYEERVYFQCLTGGTLVEHMGTPTGSSSIKMANGKAAIEVMPEKDTREFIMTVLNQNFKGTFLKVPINVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ25</accession>
    <name>A0A654DZ25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shufflon system plasmid conjugative transfer pilus tip adhesin PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024928529" evidence="2">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="319" mass="34352" checksum="C043B917120369E4" modified="2020-04-22" version="1">MKILVSILLGLLAIGAVAQGNDDLTMNNNRFVKFLASGNVDDGVKIGRFSGNALRVSYQGNVIAFDALDNRAIIFNNAGNQTKIQLHPAGKSFIKGGDFGVGLSNPDAKFHVLSDAVDINSTDEKAANLIIEASSGTRSMNEGATLGFVIPANTNGGNAWQQGRIMVTPNNESNANASGRMLLQTRYYNSGSWEWQNNLTLTAGGSVGVDVINPTEKLEVNGTIRSKEVKVEAAPWPDYVFSEGYELPDLGATADFIKANKHLPGIPSATEVAEQGILLGEMNAKLLEKIEELTLYVIELKNDNQNLSERVIELESKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB9</accession>
    <name>A0A654DZB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain-containing sensor histidine kinase (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="309"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="523" mass="59482" checksum="F737558523552C70" modified="2020-04-22" version="1">MINLSGRQRMLSQKITRLSLAISITNDSLQSDTYVVELEDAWETWKQSHDELEGAYRNNDYPALKLLFDELEVSFNEIDLAVGQLLKQNLSKDSTAIALNLETISENEPLFLSYMDQITFKLDELVNDKIDKLSRIQLTLLIITLVFIALEIFLVLRPKLAEADTNKSMHDNMLKMINQISDYAIIFLDKEGKIQNWNSGAERIHGYIGTEMIGHHITVFSSAEDQASKKADKQLQVAKENGIATNEEWIVRKDKSGFWAKTTITAIYNIEGNHIGFGRVTQDLTEAKKTEQAKVLHAKNKELEEFTYIVSHDLKVPVRTISNYIEIIREDHESELSKELLRYINSIDKAAARMQALIHGLLDYSLLGKSPTLEPLNLNQTLKDVREDLNSLIQVHDARISVGELPNLNVYPVEMRQLFQNLITNAIKFRKDDVAPVISIEGHLVEGFWKFSVKDNGIGIEEKQFEKIFIIFQRATTESKFEGQGIGLANCKKITEMHGGRLWVESEPGIGSTFYFTISSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH1</accession>
    <name>A0A654DZH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate ABC transporter substrate-binding protein (PhoT family) (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="44"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="33927" checksum="3E3F04144D411F0B" modified="2020-04-22" version="1">MSAVVGSYSSFVFSFTTMKTIHYASIIALLTIAACSQPEINHYQLRIKGSESMYETFLELKNDFEKRQDSIIISLEGGGSRTGLMAIKNHEAEIGLSSFPFDLEKTLGSDHHVSEAVVAYDAIVVITNQNNPIDSLSDESLQKIYSGTVYDWNQLGGRPGLILPIIRDENSGTQQFFVEHFGVKQLAPTAKVAHDNAEIVAKVSSNPNGIGFIGFAYFTESVHNMKLPSDSTQTQFEAPTHRNLENGKYPLKRGLRIYYRDTNNPAISGFLQYLKSKHAEGVIESFGLIPVQDKSTEISAGQPPQTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ0</accession>
    <name>A0A654DZJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34279" checksum="30F43628EE216C0A" modified="2020-04-22" version="1">MTTHNRNLLVIFMGLLLVNVLFFFLGSQRTGVSFDENKFILADTAGISNIQIGEGVALSKNTGKWRVNDQYPADPSVRQLLFSILTRVKVKKPVDIEPEEGIEVAVGGANPLNFRVWGNPTKTKTYFALTGSEEVYEVHIPGYNEYLGGLFELKPAQWRDRLVVDASWRTIQKLTLDYQQSDDSDFTINFDKDFFVVEDIAPIDSNAVVNYLNLFQLFQTNEWLSAGRFEKYDSLSKMPPLATLTIEAINQEAPVVIDIFPKLSGDRFYLLMTYEGSMLVVDDRRMKEILLKKEDFKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E025</accession>
    <name>A0A654E025_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ahpC</name>
        <name evidence="6" type="ORF">MARINOS108_120303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23285" checksum="0A9A2F54FCD0668D" modified="2020-04-22" version="1">MSLVGKKAPLFNAPAVINGEEIVENFSLEEFVGKKEVMFFFYPKDFTFVCPTEIHAFQEKLAEFEKRGVQVVGASCDTEETHLAWLMTDRDKGGIAGVTYPLVADSSKTVANNYGVLAGDWNYNDEGQLVFEGAPVAYRGTFFIDKTGVVRHETINDLPLGRNIDEMLRIVDAWQHVEKHGEVCPANWEEGKDAMQATRDGVSSYLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E074</accession>
    <name>A0A654E074_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="170"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="47169" checksum="CF2C8488D395BBC2" modified="2020-04-22" version="1">MEEHEMIELSNGIRIIHKQITNTRIAHVGIMLDIGSRDEAQNEQGIAHFWEHMAFKGTKKRKSFHIINRLDSLGGELNAYTTREKICFYASLLDNHLDKAVELLADITFNSTFPMAQIERERMVILEEMSMYLDTPEDAIQDDFDELIFKDHPLGKNILGTQDTVNSFKQKDFLDFLDRNLNTEKIILSSVGNYSAKKLQKMAEKYLVAVPHKNHTPKRNFFEGYRPLIETVNKPISQAHVAMGSTSYGLLDERRIPFFLLINILGGPSMNSRLNMSLREKHGFVYGVEASYTPYYETGQLGIYFATDPKNLKKSLRLVEKELDLMKKQPMGHLQLHKAKQQIKGQLAMSEENNNSMMLMMAKSILDLGRIPDINELFKKIDQTTASQLLELARENFQTDKMSQLTYLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B3</accession>
    <name>A0A654E0B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_12044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="339" mass="37376" checksum="881445117AD5C38D" modified="2020-04-22" version="1">MNKQLESLITAVALFIFSLLVGLTGFTLIEDLNFVNALYMTIITVGTVGFTEVKELSSAGRVFTSIYILMNLGLFAYVVSVVSSYFFEGKLKTIFKSYRSGMEISKLKNHVIVCGFGRNGSMACDELQKSGKEFVIIEKDPEMVQVIPDSMKQFIGDATEDDHLRIVGIEKASTIIITTPSDAANVFITLTARHLNDQIMIIVRASSKDTENKLYRAGANKVVMPDILGGMFMAQLVTKPIVIEFLDLLNGVSETSYHLEEVGYENLKPEYKDKTLKELNIAASTGVIVLGVKDNIKGLIPAPSADTFIGEDDYLIVLGSDAKLKAFVKEYTVLNYNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I5</accession>
    <name>A0A654E0I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="79" mass="9394" checksum="28D3CB4E02BAB61F" modified="2020-04-22" version="1">MPEVLKRIFFAMNGAFLPKDGYIDESLQEFQDYVYSDLEMSHPIEDRINMKQDVNNVRSDFRKSLKQYKEEHTENGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I9</accession>
    <name>A0A654E0I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">MARINOS108_120347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="433" mass="47579" checksum="B988DCBD3E9F0302" modified="2020-04-22" version="1">MASFRVKGGNRLKGSIVPQGAKNEALQIISAVLLTSEPVHIHKIPNIRDVIKLIDLLADLGVQIEKTDEESYRFTAKDVNLKFLDTEDFKEKASSLRGSIMILGPLLARYGTGKMPRPGGDKIGRRRLDTHFVGFQKLGAQFDYDAKNSFYTVSGKLKGTYMHLDEASVTGTANIIMAAVLAEGLTTIYNAACEPYIQQLCNMLVRMGARIEGIGSNLLKIEGVESLGGTDHTMLPDMIEIGSFIGLAAMTRSEITIKDARIDMLGIIPDTFRRLGIKLEFRGDDIYVPAQEHYEIESFIDGSILTIADAIWPGFTPDLLSIVLVTATQAKGTVLIHQKMFESRLFFVDKLIDMGAQIILCDPHRATVIGLDRAFDLKGISMTSPDIRAGVSLLIAALSADGTSTIHNVEQIDRGYQFIDKRLKALGADIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L6</accession>
    <name>A0A654E0L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZnF_CDGSH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="15422" checksum="07CFEF728AAE2066" modified="2020-04-22" version="1">MATKEYTNGEVTVVWKSDLCIHSERCFHGLSEVFNPKNRPWINAQGAPTDKIVEQVSKCPSGALSYYLNADGKPVAREVINEEQIVEVIPNGPLMVYGNLKVKLTDGTEATKNKVTAFCRCGGSSNKPFCDGTHKKNGFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P9</accession>
    <name>A0A654E0P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="49"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="17285" checksum="23CDE7D30C6BD455" modified="2020-04-22" version="1">MKTSKAEFDATCSLFINSVNNYFRHLTEIDSELNVPYIKQSEGLMLKDYTGMIGISGNRKGFVYISANRIMYEDLIKIFIGIDDPSEEDILDMAGEISNVVAGNVRANLGANFMISVPVVFQGMPSKLKIPEDVSIYVIPIVWNNHEAFVVIGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y6</accession>
    <name>A0A654E0Y6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_130005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4062" evidence="1">
        <location>
            <begin position="192"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="501" mass="57486" checksum="9BF175689597161F" modified="2020-04-22" version="1">MDFNKEILLCFSEEDNQPIEGGLKGWVSNFHKFLSTLLSQISRESPEVTLVSESNYQQVEIEKAAVIIAVCSPAFIKNEALIQRLDKHAEDVKNNDRLIIEGVSRLFKVHKAPFNEDKVLPHLDSLISYDFYMVDPLSGEAQEFKRFFGSDAERSYWMKLVDMAYDINHVLESNLSGKSGTAAEVVPMEKTVYLASTGVDMVIQRDIIKRELIRHGYKVLPQHTLSKEVGQLEQMVKEDLHKCRLSIHLIGEDYGYKPKGSDLSVVDIQNRIASNHTYEMVEYNKTAKDKRPFSRLIWVSPDLKNVTERQKIFIEDLKSDAAALEEAEVLQITLQELKAIIREELVTGGRFNKNRREIKGYTHEEEGNAKIIYLIQDKMDTSKTKPLKEFLEKSGFKVVSPSYEGDLVDIRYIHQENLRRCDASIIYFGSAKEAWIKTKLQDLLKAPGFGREKKLQAKAVYFDGQKEVDLEHYKKNKAMVLGMNGGFKPEHLKPFLTKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z5</accession>
    <name>A0A654E0Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024922600" evidence="1">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="50072" checksum="8E1A18CD647CC663" modified="2020-04-22" version="1">MQKIIVLLALVSIGFSASSQAGWNWPEDETMNAATKEKQAYYKVLMQTDKYQEAFTTINWLYKNTPNLHESIYQDGSKIIDELLELPDLSDNRKAALEDSLLWTYDMRMKYFNDKASVLDRKAYTAFKLYYRNASKYAMLRELYKELYTFSASDISDFNLTPYMTLATYYYKQKPAELSATDVLDIHGKITSVIDEKIMQGGNKEKLQKEQDKIDAFLNSLGDIISCEFIEEQLVPKFKSSPEDLNLAKKIFSYSLSAKCTDQPYFISAGEVFFQSAPSYSLAKALADKYYFAGKYDKSMYYYQQMEDLALDNEQKFDALMGQASTEVKLGNKKKARSVAYEALSVKPGASAAFNLIGNLYFLSFEECKAGESKVKDRAVYLAAYEMYQKAGNTEQMNACKEQFPSIEDIFNESREEGSKITVDCWINESVTLQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E108</accession>
    <name>A0A654E108_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="8">Kdo transferase</shortName>
            <ecNumber evidence="3 8">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_120300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 8"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_N" evidence="9">
        <location>
            <begin position="36"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="46656" checksum="111ADC6B84858A28" modified="2020-04-22" version="1">MLLLYRMSVWLYALIVRVIAPFHRRAGQFISQRKGIFERLESDFRNHEGKLIWIHCASLGEYEQAKPVLGLLQERRPSVKVLLTFFSPSGLLGFKDQELVDYLHYLPLDARGNASRFLETVRPSLAIFIKYELWYYYLMALNARNIPLLLVSGIFRRSQIFFHPMGKFYLTALSTVNHFFLQDDYSAALLRSRSIRAYTVAGDTRFDRVLEVANAAGEVPLVEAFKGNEKLIVMGSVWPSDMKYLLPIVEANHDRFKFIIAPHQVGDLRIYEKIHASAKYSELNEGSASALRVLIIDNYGMLSKLYRYADYAIVGGAFRGALHNVLEPAVYGIPVFFGADASNEKFIEAIELVKHGGGFTYENSADLQSKLDEMTNDADLYQEVCRLSRTYVSARTGASGQVMKKIEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E122</accession>
    <name>A0A654E122_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mraY</name>
        <name evidence="8" type="ORF">MARINOS108_110114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="392" mass="43467" checksum="D034F64617210B87" modified="2020-04-22" version="1">MLYYLFDFLDKQFDLMGASVFRYISFRAGMAAVISLLITIVFGKRFINALRNFQMGESIRDLGLKGQMEKQGTPTMGGIMIISAIIIPTLLFAQIGNVYVQLLLITALWMGLIGFTDDYLKIKKKNKDGLKGNFKVIGQVGLGLLVGLVMVMHPDVVIPELGGMGIEDSSSIVTTIPFFKDNEFQYDWLLPYFLEDYTWLIYVLAVIFIITAVSNGANITDGLDGLAAGTSAIIGLTLAILAYLSGNAVFAEYLNIAFIPNSGELVIFSAAFVGACIGFLWYNSYPAQVFMGDTGSLSLGAIIAVLALVIRKELLIPILCGIFLIENLSVIIQVSYFKYTRKKYGEGRRVFLMSPLHHHYQKKGWHEARIVTRFWTVGILLAILTLATLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E148</accession>
    <name>A0A654E148_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rbfA</name>
        <name evidence="2" type="ORF">MARINOS108_140014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14736" checksum="A4E3A0DACCC0D1FB" modified="2020-04-22" version="1">MTQNKRQHKYGRQIQKDLSEIFQRDTRHYFGHSLVTVTAVEMSPDLGFAKIFLSVFPIQNTEDVFFNLNEKKSEIRKHLGNRIGKQVRVTPELAFFHDDTEERASRMDQLIDGLNIPPADETEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E173</accession>
    <name>A0A654E173_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3857" evidence="2">
        <location>
            <begin position="77"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="318"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="661" mass="76142" checksum="ECA52DAE4E92AA87" modified="2020-04-22" version="1">MNRVLQSSQPIRLLIVLFFVALAGASTAQRYSQEFGVIAKDEFDLELYSDDPEAEALILFDVGDSYFLEGNTGFDIKFTHSKRLKIFTSAGFDYAEIEIPYYVEGNKRERVEEIEAFTYNQLENGTMERISLNQQDIFDEVKNKYYRVKKFAFPGVKAGSIIEYRYKLISPFKFNLPDWAFQSTIPTLYSKYTVRMVPFYEYIYLMQGGKFDSHRSYTSSELPRYFGSVKYNDFVHEFTKKNIPAFKDETFISSTDDYIIKMDFQLTQVNNPNGLKTEIITTWPKLIEELNDHENFGKYIKKAQKFSEKTILPSLNLSNKTQTEKAGLLVDYVKNDFSWDRYYAKYANQSVKEFYAAKQGNAAEINLFTIGLLNAAGIKAKPVLISTRDHGKITMDYPFSHFFNYVVIIIELESGKILTDATEPLLTFDRLPPFCFNDNGLIIDEAGVGWVGLESPKASLNNYTISQKPDPDSLKSTILVSSQMTEFEGLKMHKNYGTDDRLLTESLEKGEYLDVHKVSFPGRSQNSQYSFAFTGACQLERVDGKFLISPFLNLPIDENPLKYPSRTYPVDFTYKTTDHYQSIIEIPEGYRVTYLPSNQNIDDHLMTIKYNIISTDKSLTVDGQIEYKKAVYSSGEYLRIKNRLDTIVKTFNDQIVLEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E187</accession>
    <name>A0A654E187_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="332"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="434" mass="47806" checksum="AA6433E58E1ABF6C" modified="2020-04-22" version="1">MKNFKYILLSLLFTGVFSCEIEEISDPNNPSLVDIEADATKSDILLLITGTEELMRSEIGFYYDVLGILGREYYFFTNSDPRYTGELLGKGDAVLDDAGFYGTRPYAGRYKVIRNANILMTAMANTSETLTEAERNGVKGFAKTCQAYSYLLALNLQYQGGIRIDVADTENLGAFVGYDAALGAIALLLDQAYTDLNGAGSEFMFSLSSGFAGFDDPATFGEFNRAIRARVALYAGDEAGALEALGDSFMDLNGDLDAGPKHYYSVVGTEEINPIFRAPDQSEALIAHPSFVTDIRAGDTRMSKVTERTETAVLDGLSGDYDVTVYPSNASPIPIIRNEELILIYAEANIGTDNIEAIDALEVIRDAHGLGVYTGGFTDADVRNELLYNRRYSLFGEAHRWIDLRRYDMLQTLPKDRAGDDVWTQLPRPVSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E191</accession>
    <name>A0A654E191_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">MARINOS108_120380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="156"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="34272" checksum="8E702F7EA9B62A74" modified="2020-04-22" version="1">MSQLKTKHLLGIKNLDRDEIELIFETADNFKDVLNRPIKKVPSLRDVTVANVFFENSTRTRLSFELAEKRLSADVINFSSSSSSVKKGETLLDTVNNILAMKVDMVVMRHSSPGAPHFLARHIKANIINAGDGTHEHPTQALLDTFSIREKTGGVEGKKVVIVGDILHSRVALSNIFALQKLGAEVMVCGPATLLPKHIASLGVKVELDIRKALEWCDIANVLRIQLERQKMRYFPSLREYSLYYGINKELLDSLNKEIVIMHPGPINRGVEITSDVADSEHSIILDQVENGVAIRMAVLYLLAGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K4</accession>
    <name>A0A654E1K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="6357" checksum="B8049BBAA8529B9F" modified="2020-04-22" version="1">MFIRRELVERIQIFIIIITFAANKIWNEVKFTALKARRNRQEDFRDFTIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T7</accession>
    <name>A0A654E1T7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="19041" checksum="A85C429BEF08A3D8" modified="2020-04-22" version="1">MMAVLAMGVMLSCSSGNTERTDDQATSAATSHPKGQASVSDNVSDRNILQVAVASDAHTTLVAAVEAAQIEHVLVNAGPLTVFAPTNEAFNLLPEGVVENLLKPENKSDLATTLTRHAAPGSFDLEALKREASKGRKIYMATGDYLEVKVDGDNVSVGGANILATISTSNGIIHVIDKVIASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V4</accession>
    <name>A0A654E1V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">MARINOS108_20113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="11417" checksum="326E9B6EF81E8176" modified="2020-04-22" version="1">MYAIVDIAGKQFKVEKDNFVYAPLLEGEEGTKVDFDQVLLVDNDGKVKVGAPTVKGAKVSGTILGHVKGDKVIVFKKKRRKGYQKKNGHRQNFSKVLIEDIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W2</accession>
    <name>A0A654E1W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="26713" checksum="D4AA4DBC8485FDE2" modified="2020-04-22" version="1">MTLKHRSEEMEIMDDLSISGEVIGQTLRELDIINRRLGGNHISLRAFAKILKNHRIQTVADLGCGGADILMAMARIAKRKNQDIQFTGVDANQHIVEYANDHTREWANISIIQENILSEAFRRQHFDIIHCCLFLHHFTESQLISIFKSLKDQARVAIIVNDLHRHILAFHSIRLLTRFFSKSYMVRNDAAISVARGFKKSELAAILEQAGISNYQLSWRWAFRWQLVIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y4</accession>
    <name>A0A654E1Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024852754" description="Plug domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="3">
        <location>
            <begin position="118"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="992" mass="109659" checksum="0414A90D3702E808" modified="2020-04-22" version="1">MIKRFTLKKGLVISALLFVSFLAGAQSVIKGKVIAEDGEAIPGATVLIEGGTTGSITDLDGNYTIQAAPDDVLIFSFVGFESQRVPVNNQSRIDMTMTVDIAELSEVVVMGYSEKSRRELTASATTIGEKDLKNVTSSNIESMLQGKVAGVSVTTSSGSPGEPAEIRIRGVNSLTADRAPLVVVDGIIGGTYQPNDVASVTVLKDAAATSLYGSLASGGVLIVTTKQGKGDPVIEFSTSVGVKEITTGNFSMMNGSDLYDLQEIMWGDERVNFLKVRPEDLRDRDFNWLDESFKRGVLQNYYLSARGGTDKMTYAVSGDYYQEDGTLLETGYERMSLRTNLNFQLKENVSLKTNLSLISSERNQDFWDWRYDPFLYLPWDSPYSDDGSIKYIDNTSSEEWYGRDSKNVLHSAQYNYNNSKGLDFSGNAFLNIDLTDWLSIESRNRVSISHGRYESFYDPRTREGKASKGSISTSTAASKDAISTLILRGEKSFGKHTVGGFIGAEGNYYYYENLGASARNIPIGLNVIGAASEPVSIYGNNVTGTRLSYLSEMSYSYGGKYFVTGVFRADASSKFGPESRWGYFPGASASWIVSSEDFFVYNNVISFLKVRGSYGEVGNDNVGSNSFPYLSYYDLSDQYNGIPAATIPLLANNNITWETLVSRNIGVDLTFFNRINATFDYYNNTTTDLLLDVQLPLSTGFEIQARNVGEIRNQGVEAAISADIFKGNGINWTSSYNVAFNQSENLKFADTDQLLFGTDVNQISAVGEELRQWYLPKWLGVDPANGDPLWEKVNRDASGNVVSREATSNYNEAEFQRVGSVLPKLYGGWTNSVSYKGFSLSVLLSYQYGNKVYHSARQLFDNDGAYTEYNMMELQDGWSRWEKPGDDATHPLPKRGGNKLSNAPSSRYLEDGSYIRLRNVSLTYSFPQSVCNALKLQSLNLGLSGDNLYTWTKFSGLDPEARVSVAAFELPGFQDFKYPISKQYLMKLTARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E243</accession>
    <name>A0A654E243_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdd</name>
        <name evidence="3" type="ORF">MARINOS108_140152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013171">
        <property type="entry name" value="Cyd/dCyd_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08211">
        <property type="entry name" value="dCMP_cyt_deam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="16985" checksum="F9D712414AFC23F1" modified="2020-04-22" version="1">MNQSFTFEYQRLTYDELTPADQQLIDAAMQALDGAHAPYSHFQVGSAVLMADGSVVTGNNQENAAYPSGLCAERVALFAAKSQSKQPIQAITVVARNAQGEMADAFSCGNCRQVMLEYAGQQQEGLRVIMGDRTGHFIVLADTRQLLPFSFGSETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E284</accession>
    <name>A0A654E284_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="37872" checksum="45A5BF7673F8F83F" modified="2020-04-22" version="1">MTEYYAIGVMSGSSLDGLDVCLCRFISEQGWSFEIIKSETIGISPEITTQLKQADQLTGRDLALLDIQYGRWIGNVINDFLKDLSLPIAVIGVHGHTVFHLPGQQLSMQIGNAEAICVITQTPTVGGFRGMDVLMGGQGAPLVPFGENQLLPDYQAFVNLGGIANVSVHTHQIRAWDVAPCNQILNHFAKQLGHVFDDGGHLASSGQMDMPYLAYIRSLEYFHLPPPKSLSNQWSAQVLSNAPENPANGLYTYSHFLAEQLANDLSQVQGKVMLTGGGAYNDFLIQLLKEKVSPDLEILLPAPQLIDFKEALIFAFLGLMRTLRLPNVLSSVTGAQKDTVSGTLHLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C9</accession>
    <name>A0A654E2C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="57" mass="6743" checksum="34BA89F519FB1C31" modified="2020-04-22" version="1">MVGFKKHMDKEKEEKAKKRLEELKKKAQQEEENSEHKEVDKEEVPREAFRKNLGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J4</accession>
    <name>A0A654E2J4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hemB</name>
        <name evidence="13" type="ORF">MARINOS108_20425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD18785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="36111" checksum="37DF5106980E5A0F" modified="2020-04-22" version="1">MERRPRRNRASQAIRDLSQETLVTANDLIYPLFLLEGSHKKTEVKSMPGIFRLSLDLMLKEMEQCLKLGIKGFDVFPVVEDFHKDKLATRSYDRGFFYIQALDTIKKEFPEALIITDVAMDPYSSDGHDGIVKDGKILNDETLDVLGQMALAQAETGIDMIGPSDMMDGRVGHLRNVLDEAGFSHVGIMAYTAKYASAFYGPFRDALDSAPKFGDKKTYQMNPANRKEALIEAELDYIEGADVLMVKPALSYLDVISDLKANYDLPIAAYNVSGEYAMIKAAGLQGWLDADRVRDEVLLSIKRSGADMILTYFAKEFCSQTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M4</accession>
    <name>A0A654E2M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="26638" checksum="4595624C89471BAD" modified="2020-04-22" version="1">MSNDRKIIWNPEEPVFISDSSKDFDRLVRRAQQRKFTVKIWRQASTASIMGIGVLTIILFNLPETESPTPNIHTAPLSSEIGPFLSPISMVEIPANSQRISKTELAIPAANEKPENELERKEDKETFTPTEYTRAYPAVGMDSLYAYFNTGIHDLLKSGEYPVTSTKTTVNFMIDQTGRPVKISVNALEHTLLEEKIIGLVTGMPEWDPATADGVPIATWFAIPLGLEYQVVLDSGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q3</accession>
    <name>A0A654E2Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="81" mass="8501" checksum="73DE7E5A72E98D0C" modified="2020-04-22" version="1">MCALNQQINLFIMKNKIYLALISLAFFACGGAGTSQSESTAADTVEVSEPIAVVEEVVEAADSLAMEVSDSVEVVTETVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q4</accession>
    <name>A0A654E2Q4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrous oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026468">
        <property type="entry name" value="Nitrous_oxide_Rdtase_Sec-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041114">
        <property type="entry name" value="Nos_propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18764">
        <property type="entry name" value="nos_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04246">
        <property type="entry name" value="nitrous_NosZ_Gp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="652" mass="72452" checksum="361C3E8F3914B676" modified="2020-04-22" version="1">MKTISVLSNVFIVGAFILITSCGQSGSNGKSALSSNVAEKVYIAPGERDEQYAFLSGGYSGNLTVYGLPSGRMFKEIPVFSQFPTSGYGYSEETKPMLNTSFGFVPWDDLHHPDISQTNGELDGRWIFANGNNTPRIARISLSTFETEEIIEVPNSAGNHSSSFITENTEYVVAGTRFSVPVPQRDIPISEYKSNFKGALTFISVEPEHGHMEIKFQLLMPGFNYDLSHPGRDKSHGWFFFSTYNTEEANTLLEVNASQNDKDFIAAVNWKMIEAYVNNGGGKKMSTRYAHNVYDESTHTATSTMNKEVLTVDPAEVPGAIYFLPTPKSPHGCDVDPTGQYIIGSGKLSADLTVHSFDKMLAAIKAEKFDGEAYGIPILNYQDVLAGTVSSGGLGPLHTEFDGRGNAYTTFFISSEVVKWKLGTWEVIDRKPTYYSVGHLMIPGGNSRKPHGKYLVAMNKITKDRYLPTGPEMEHSAQIYDITGEKMELLYDFPTHGEPHYAAGCNAELLVNNSKKIYRLDENNHPYAIKSPAEARVERTGNEVHIYMSTIRSHFTPDNIEGIKVGDKVYFHITNHEQDFDVPHGFSMIGQGTSEILIMPGQTKTSLWEPKRVGVWPFYCTDFCSALHQEMQGYVRVSPANSDLELSWSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R3</accession>
    <name>A0A654E2R3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="223" mass="25394" checksum="3CD3C7F387C313ED" modified="2020-04-22" version="1">MNYLLKTDWWKWLAMILLAYIVVGGLLFTVPRLPILNETIRVLHFHVPMWFGMLFLFLASVIHSIRYLSNGEHKHDIISSQLATVGILFGVLGMVTGMFWATFTWGEPWSSDPKQNASAIGLLIYFAYFILRGSLQDEQQKARISAVYNIFAFAALIPLLFILPRMTDSLHPGNGGNPGFNAYDLDSNLRMVFYPAVIGWTLLGFWVTTIKIRYALLIQKTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T1</accession>
    <name>A0A654E2T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031977">
        <property type="entry name" value="DUF4783"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16022">
        <property type="entry name" value="DUF4783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14355" checksum="6AB904A8F1F55D42" modified="2020-04-22" version="1">MIKIGFLLSSLLFTFFTPTQEDILANIAVAMKAGSSKELIKFCNTNIEIKVDGKASNYSIAQAEVVLKDFFLKNPPKGFQYIHQGSSPEGLKYTIGTYSLEEGSYRVVMVVKNVKNQFKIDTINFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W6</accession>
    <name>A0A654E2W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="11144" checksum="1DB8A4087BF12CC8" modified="2020-04-22" version="1">MPMKNTFLVIVGFLLLSCKKDCCESIPDRPAFKFVNADGLDLLNPITPDSLEADDIEFWTIKDNNQIPLFASIQERIRFTSDTSFWLLSFVKTGKLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W9</accession>
    <name>A0A654E2W9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">psd</name>
        <name evidence="7" type="ORF">MARINOS108_20609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="5">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5029072666" description="Phosphatidylserine decarboxylase beta chain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029072667" description="Phosphatidylserine decarboxylase alpha chain" evidence="5">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="5">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="24516" checksum="CF1246E6DF908CB6" modified="2020-04-22" version="1">MNIHKEGYKIIPIAAIILVLLYALLYWLIPFQVVQVILGLAAVIFFILVVRFFRDPEFPVEKNPSQIIAPADGKVVVIEETEESEYLKDKRIQVSIFMSPLNVHVNRSPVAGEISYFKYHPGKFLVAWHPKSSTDNERTSIGLKLASGVEIMMRQVAGAVARRICFYSEAGKPVEQGEKFGFIRFGSRIDLYLPLDAKIKVNIDDISYGGKTVIAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y9</accession>
    <name>A0A654E2Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gliding motility associated protein GldN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019847">
        <property type="entry name" value="Gliding_motility_assoc_GldN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19841">
        <property type="entry name" value="GldN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03523">
        <property type="entry name" value="GldN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="31895" checksum="E87256E1AF0CACD3" modified="2020-04-22" version="1">MKKFCYALLIGLLTVPVLYAQEVKIPIIKPEVQESQIMFQRMVWRRMDLREKQNQPFFSRNGEISRLLLDAVEEGLLKPYMTDSCLNLMPDSVFKTKTTVERQGGADFGGGFGGGFGGGFGNESSSQAQSSGPKADAIPKDVFDVMYIREEVMFDRNRSRMYWYIRALTIALPGRAGSTWNPAGFENQVCHFKYEDVVALFRGPYADKAIWYNNQNQAAHRNYGDALELRLFSAPIIKMSNAQNLDIRQLTSDPFDAVMLQQKYEYDLMEYESELWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E314</accession>
    <name>A0A654E314_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024877915" evidence="2">
        <location>
            <begin position="19"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="498" mass="56589" checksum="B87780902C3A3CE5" modified="2020-04-22" version="1">MKRLIFIFSFSLFLSAYLSNDGRAQLITDSENRLKTQKQKNKGEGFSLFKKKKGASSHGAQKHEPISSSPRYSSGSPFASFNKRKSVTPRSSSSNRSRLFKSYEHKAPRYSSSGIAGIMSGKKSSTRYSPGSPFTKKDKFVSPRYSAGEPFKQPFLSQIFDQRYGPRYSAGSPYTKKDKMASPRYSAGDPFRKQFSLSGLFNKDSGPRYSAGSPYTKKDKMVSPRYSAGGVFTTRQKSVSPRYSAGDPFQKQFSLSGLFSKDSGPRYSAGSPFTKKDRMVSPRYSAGNVFTTREKSVSPRYSAGSPFTAKDKSVNPRYSAGSPFTRKDKGVNTRYSEGSPYDGMRWGWISPAYSTNKHRFDVNEKLKKSRVYDYADTEYKGTYRKKSKWYYDLDNLIVSGVTGAFESRQKAELYDPQQNKEAAAYTGTYKKKWITENNMHPSANYTKANQDSEMIRNSMRKWNLFWTRVNRNKQQPNAVTDTTLKPKFDRKEAQIWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E327</accession>
    <name>A0A654E327_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011396">
        <property type="entry name" value="UCP030850"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030850">
        <property type="entry name" value="UCP030850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="214"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="322" mass="36812" checksum="D6922E06B2E17955" modified="2020-04-22" version="1">MNQLIAKYLKAFKKLRVDRSHGIAPHKPILLITIIESYQTGEILNRRVYITPELVALFKSIWSSLVTTSHDCRISYPFYYMKSESFWKLKPKAGFSDIDKMGSLVKSFSSLNSAVDFAEIDKELFELLISETDRAILKQFLLDEYFPNSQGKFGDGSEGARGLISGINDQIVNEPPAEYRASIRQLINENNDEEIFLRGSLFKREIPRIYNHRCCISGMQVDTPHNISMIDACHIIPFSESYDDTVTNGIALCPNLHRAFDRGLISINSDFSVIVSSSFIENESDYSLKNLEGNKLELPSDERFWPSIENLEWHSLTIYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E371</accession>
    <name>A0A654E371_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="43950" checksum="510A3990F72C4DF3" modified="2020-04-22" version="1">MSYLQIVRKHPQILGYGALHYFFSAIGQTFLISVSVPYLLRDMGLTSIGFSNRYAIATISSALVLPLVGGWVDRARLSTLSFLGGLGLLTACLMMFFSARYALLLPALFLMRFFGQGSMVLIGSTAIAKFFTKNRGKGLSLASMGLSLAETFMPLIFVGLIGLYSWENAWLIMGSGVILIFIPVSYLLIRNHLPGQEEVGTPLSTTINDFTRRQVLGDPYFYMTVPVMLFLPFFITGIFIHQNLIAQAKGWTMDWMAFTFIGFGFSKVVTSFLGGALIDRFTARKVFVFYLFPLAVGLIFLAIGEHKIFALVYMILLGMTASLGTLTGVAIWVEMYGSKNLGAIKSMVTTFMVVSTAVGPILIGWALEISLEMTLYTFSGIILLLILLSYLVVNRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H3</accession>
    <name>A0A654E3H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025054414" evidence="1">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="33651" checksum="842CA42B961BFE95" modified="2020-04-22" version="1">MRILVFLLCLVAGQLQAQPSRKDADAQYSNEQWTEAAKGYQHYLKKNEKDSSAWYRLAFCQLKLGAYEASLKNFDEAVARNFYPGYTLYTKSKAYALLEKQAKAYETLQAALDRGFSNFRLMESEEEWSPYQQDQKFLSLLYACKVNAYPCLSDSVRRHFDFWLGEWDVYVKGTKVGENSITLANGGCALHESYTTPGTYTGQSINYYDKLDNKWHQTWVGSAGGVLDYVEIDKRPGMIQFQCDYRDQQGNVVKSRLTFTDNGDGTVRQLFENSSDGETWTPGFDGLYKPKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M1</accession>
    <name>A0A654E3M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="13681" checksum="5A652ADEC0317055" modified="2020-04-22" version="1">MNALKVTMFAALICLGYQGMAQRGSFDPAERVSQEKQNVLESMEDLTEDQQVVIDQIYENHLEKVQEITASTDGPSPEVREKMMVINKEKNELMKDVLSDEQYAKYEQLIARKGRGPRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E411</accession>
    <name>A0A654E411_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_50010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="32158" checksum="BE4B61AE5E7277E3" modified="2020-04-22" version="1">MDKPQEIHIYEPESQLHHPLRLLRSILIGFSEGKFLAWRLFRRNISAMYRQSFLGLAWAFIPPIMSTLFWVFLRGQNVFTVDDTPIPYIVFVFTGTILWQIFLDALNTPLKVIQQAKSMLVKINFPREAILLSGFYEIVFNLLIKLVLLIFVFVFTGMHFHVSAFAGLIGILTIIFLGFTFSLILAPISLLYGDVQKGIAIITQFLFFLTPIIYPMPKGGMIAVVARINPVATILDESRTWLAIGYNGVSADFILIFGLSLLGMVCGLILFRLSLPHLIERIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E426</accession>
    <name>A0A654E426_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="22365" checksum="6F748375370D3332" modified="2020-04-22" version="1">MKFISSNKDEQPDEALLIRYQQTGDKALIGALFSRYVHLVYGLCLKYLKDRDGAQDAVMTIFESLFKKLLDHDVKYFKSWLYMVAKNHCLMELRKAGTSKDLNGSIMENEVFLHPIEEMPTDVTDDLDAMEKCLEQLRDDQQKCLRMFYLQELSYEEVSTKTTFALKKVKSYIQNGKRNLKICIEKQHADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E454</accession>
    <name>A0A654E454_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Outer membrane cobalamin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024851408" evidence="6">
        <location>
            <begin position="20"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="391"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="989" mass="106738" checksum="EC04EEED349EDDCA" modified="2020-04-22" version="1">MKKYLLLGLSLILSATLWAQERTVTGTVTDAETGEAVPGANVVEKGTTNGTITDFNGQYKLAVGDGATLVFSFVGYASSEAVVGSRGVIDAALDLDVQSLSEVVVVGYGTQDKKEITSSVASISSEDFNRGTVNDPVQLLQGKVAGLNITKPGGDPNGGYNIRLRGISTVGANASPLVVIDGVIGGSLSTVDPNDIASIDILKDGSAAAIYGTRGSSGVILVTTKTGSKGKMQVDYNGSYAVESIYNTIDFMTADEYREVPGAQDFGSDTDWMDEVTQLGQAQVHNLSLSGGTGQTSYRISMNYRDTEGIGIGTGFSQLNGRVNITQRALNDRAKITVGISSTTKESDYGFAEAFRYAVVANPTMPVNIAASGGGLTEQGGYAQRDIFDFFNPVGIAEQNVNEGVDHRLLASVKAEYDFSDLVNGLSASVFYSRQEENDLRGEYYSKNSKFRGAGRNGLARKSNERRTNQLIESTVNYNKDVSDLNISLLGGYSYQEFFTEGSGMEGGDFLTDAFGYNNMGAALDFANGLGNLWSYANSYKLIGFFGRLNLNYDNTYFLSASARYEGSSRFGINNRWGIFPAVSAGVNITNLVEIPTVNSLKLRGSFGRTGNIPGQSYLSLQRYGPQGNFFYNGEYVPSFGPVSNPNPDLSWETKDEIDVGIDFTLLDNKLSGTVDWYTRTTTDMILSVNVPVPPNLFGQTWVNIGEFANSGLEVALNYQAIVTNDFTWSTGVNFSTFKTEVVSLTSGDLSFGEGGVLYRANMGAPGQNDTELVRVKEGEELGQLWGPVQIGVDEDGTPRFADLSGDGSYCNCDDDRTVIGSGLPDATFGFNNSFTYKSFDLNIFIRGAVGHDLLNSYRGFYENNESTTVGNYNVVKTKYYDSNVKKASVNSVHVESADYVKIDNATIGYNFPLQSGSAVRKLRLFASVQNPFVLTNYTGVDPEVRYEDRIDSDNGGRPGDADTLSPGIERRSTYFTTRTFTLGLNLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A5</accession>
    <name>A0A654E4A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_50063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="100"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="279"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD20613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="529" mass="58966" checksum="D9C482CDE699830E" modified="2020-04-22" version="1">MKKYRYLFIALLLTFTTSFWGCDKLLDDIELRHSLSAEEAARTAKGSDAILSGALLAVRSTFRDPGISVYKACGTDIVRDGTNLSDEPASGMPGMNSYNGSFAANSTQVLSIWDTYYSGITFANTAINGLVSSGSVDDLDPEIKDKLGQAYTMRAYLYLELVRRFGNIPIIAAADLDQGPVFEAEQRQESEVYDLIISDLETAVPLMFTRSEIGDRGVLIPSKGLANLLLAEAALDRGLYEKAAAAAEAVITDPSYSLQPLDGIFGLDGGKSGEENNAEIIFSIGFTSDIPDEVQWTSQHFMPLYDRVNGVARTMEAGGRPWSRLSPSDYYWTLFDEADGRLEAWHKTHWVFDDPEALPDGRNIGDRVEREDLEAQFGEDPIRLRYADPTTFKYYEDNTYGRTTAQAEGWRNIILFRYSHAYIAAAEAYFGQGNTGQAMTYLNVLRERAYGNVTGNFSSITLEDIVEEQARELGHEGHRWAFLKRNDLLVERVRMHNPAAAPNIESKHVRWPIPLEFIDQTGSTQNTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B6</accession>
    <name>A0A654E4B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="20571" checksum="314D7B110292FA23" modified="2020-04-22" version="1">MKILYTCLLLSSLLLTSCFEYEEELSLVQYGSRDYALSGVLQEDWGAHSGDHYNMDFTIIGETSVFEENQNALGETYFTLSEDFDCYLFTEFFSPGKEGFQEGTFTALGNRKLSEAEGEFVYRRVQFGRSLEEAIFGENGTITIVITSKGVYRMKYDILMENGRKLEGTFIGTPQYLDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E4</accession>
    <name>A0A654E4E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="907"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="780"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="969" mass="111483" checksum="D166BC38E9108BC6" modified="2020-04-22" version="1">MKMHIKDWKIVLVGCLIILLSPLFGQKSDDNATARAEIKGTPRIIHYTRKDFSGDPQIWAMCQDNDGIMYFGNNDGTLIFDGARWQTVSLPNNSSVRSLLHTTDGHVYAGGFNEFGRIERDEYGQYSYHSLIDQLSPEDRNLENIWAIHEVQNHIVFRSLSRLVAISNNKAFTIPSTGFYHSAVINDKLYLVNGEGVKTLDLQTLSFESLVAPSQFNQETIVAMVEGTAENQVILFTRSGASYTIDHGSKNIHFFKSYFTGNSNNQILSAIKSSAGHYYLGTLSSQIMVLDEHGDPVPLTESFMELQDNTVLNLSESSEGNIWALLNNGIDCINISSPISVLFENASVFDAMIRGGKIYAATNQGVFVSQRIVQNPHFASMEFRKIPGLEGQAWSLLSLHGQILCSHNDGLFVIDDNNILKIEGLAGVWKVIPIKGKDNHYFVCTYTGIHMLRFEDGKFELLYRVDGFNESSRDIIQSDEENTFWVCHGYKGVFKLQFDRNFERVVGLEHFREKGLPSPFSINVFRWNDHIVFTTNQGVYTFNETSNQFDPMTELNERFGTDVNVRKLLQYEDKTWFVQDDEAGYFQGDSKKLEKGLFLELKGTFNRSMESILPINTSNVLIGTTTGLYAYDLSFQQHADTKKTLITEVNYQYNGERTKRSLKGSSEQIPHSASDLRFEFSAPKLKDQTQVQYSHMLEGIDEDWSDWSVDPFKNYSQLFPGKYTFKVKARSMIGETTSESSYHFTIAPIWYLTRWAIGAYVLMILLIMIGSRKLVKKKIVVEKEKTREEEKKKRTVLELELDQMRLEREKERIERDKKILEEDVIFKSKELANYTMLLVKKRELLTDLREDLKELKEVAKNERSRNMLRNLIRKIGVNLNDEEHIHVFEANFERVHDDFFQELKTYFPDLTSKELRLCALVKMNLTNKEIAPILNISLRGVETARYRLRKRLSLDHEENMVEFLEKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H7</accession>
    <name>A0A654E4H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_60051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="293" mass="32694" checksum="6C099D45E72840EC" modified="2020-04-22" version="1">MSQKVALVLSSGGARGLAHIGVIEALEEKGYEITSVSGSSMGAVVGAFYACGKLKEYKEWALNLDRYDVFKLIDFTFSVQGFVKGERVFKTLKTIIPDQNIEDMRIPFAALVTDIKAKTQEVFRTGSMYQAIKASVAIPTVIKPVMINGREYIDGGVTNPIPIEHVHRTEGDILVVSNVNAIMPFVKVKEDKVLEAESATYNQKIQAFINGWGKLLPGNTETEKKLGFFDLLNESIDLMQDKLTSLLLEKYKPDLLVNISREACSTFEFYKAKEMIELGKDLFEAAYQAKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H9</accession>
    <name>A0A654E4H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="458"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="700"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="912" mass="102099" checksum="93070C274C284002" modified="2020-04-22" version="1">MRYFFKIGVLCCFLLVFGHWVSAQLLHTEGQKIVDSEGNEVIWRGIGLGGWMLQEGYMLGTSGAQHVLEQRIEELVGAESKEQFYEAWLANHTRKIDLDSMARWGYNMIRLPMHYKLFTPPIEEEPVAGEITWIDKGFEMTDELLEWCTANNMYLILDLHAAPGGQGENADISDYDPSKPSLWESEANRAKMVALWRKLAERYADEPMIGAYDIINEPNWGFQNHDSDPNGCAESQNTLLWDLQKEVTAAIREVDPDHIIVIEGNCWGNNYSGLPTLWDDNLVISYHKYWNGNTQGDIQGMLNMRTERNVPIWLGETGENSNKWFTDCIELLEDNSIGWSWWPLKKLGLNNPLEVPYNDDYRAVVKYWNGEGAKPSQEVALAGLMQLAEDIKLENTLYHKDVVDAKIRQPHTLDTKPFKTHRLTEGQATVVQATDYDLGRNEYAYYDKVSANYHGSTGEYTAWNSGWAYRNDGVDIEPIADSEEVTNGYNVGWTEDGEWLQYTVEVDVSGAYQVVVRYAGQAAGSIHLEVDGVDISGPVELPATGGFQVWKDQVIENVALESGTKSIQFHIDKGGFNFSYLSFFLTGELSELDFKALSSTTYDDESILLNLNKRVKQESISSAGFVVSVDGEDLTPSEVMINDKSEFQILIKLSETLGDDNVILLSYTGTNLEAQDGTSLEAFSDLPVDNQLPAHFSIPGKIEAEDFEVNVGLELEATTDTGLGQNIGYTSTGDYLEYLVNVQFSGVYDLDVRIACNNNSGKLAFQQLDKEGNVLNEAQVDVPVTGGWQTWETVSAQMTLEEGRGRLKVKILDPEFNMNWFRFTAAPEILGAEAPGRLTFYPNPADDFLMINAPGLGGLLQVTIHNLSGQLVFKKQEVHNQERIDISGLPGGLYVIEVSGEKGTLESKVMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L1</accession>
    <name>A0A654E4L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="26034" checksum="108857E093B9F809" modified="2020-04-22" version="1">MNGLNKYRQRFLDDWYNIDGKAFFFVLCLLYFSAFLIKRMFIIDSIAAFEILQDRGEMWIMDVFFGLQYLSVPIFIAWKFTLTSFLLWVGCFLFGYRVTYAQLWKMVMIMELVFIIPELLKVVWFTVFETDPTYHDFVAYYPLSLINFFNYESLDAKWLYPLKALNLFEILYWGMLVAGIYWLSNKKLKTSLFITLSSYVLFFFLWLIYYVIVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E503</accession>
    <name>A0A654E503_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_90079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="23414" checksum="13450D2FF1FF27C5" modified="2020-04-22" version="1">MTIRRKIHNINSLDDTHQWFKSCYDQNFTSLYQYAKSITHDVQSAEDIVSEVFMNLWSNRDSLTSIRDINSYLFITVKNSAIRFVTRNPNSFFGSNLEETIKEIDRHDPEQVMLEQELVGAINDAINALPDKCQIVYKLIRQEGKSVKEVATEMGISEGTVKNHMTKAVSRIREEVTDYLEASGGTKSNYGSFSVLLFLGTMGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5K7</accession>
    <name>A0A654E5K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="351" mass="39277" checksum="67C49BB21F406F2C" modified="2020-04-22" version="1">MKTIKGPAIFLAQFADDKEPFNNLKSICKWAKGLGYQGVQIPAWDGRLIDIKKAAESKTYADEIKGIVNEAGLEITELATHLQGQLVAVHPAYDIMFDTFAPDSVKGNPKARTEWAIDQVKSAATASKNLGIDVMASFSGALLWHTVYPWPQRPAGLVEMGFEELAKRWLPILDHAKDNGVEICYELHPGEDLHDGITYERFWEATGKHSSAKILYDPSHFVLQQLDYLQFIDFYHENIRMFHVKDAEFNPTGKSGVYGGFQGWVDRPGRFRSLGDGQVDFSGIFSKLSQYGYDGWAVLEWECCIKSPQQGAEEGAPFIQNHIIEVTEKAFDDFAGAKPDDVANRKILGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5N2</accession>
    <name>A0A654E5N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">murQ</name>
        <name evidence="5" type="ORF">MARINOS108_11237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="271" mass="29195" checksum="B337F06FA951625C" modified="2020-04-22" version="1">MDKLPDTEKASKYERIEEMSTLDVLSNINREDATVADAVALAIPQIQRLVDAIVSRMQTGGRLFYIGSGTSGRLGVVDASECPPTFGVPHDLVVGIIAGGDGAIRKAVEFAEDDQKQAWEDLKAYFPDEKDTVIGLAASGTTPYVIGGVSEARAHGLLTGCIACSAGSPLGKVVEFPIEAVVGPEFITGSTRMKSGTAQKMILNMISTSVMIKLGRVKGNKMVDMQLSNHKLVARGVRMLMNELKIDQREAESELKRFGSVRAVLKNREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5S8</accession>
    <name>A0A654E5S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="33674" checksum="1CC18A0CACA95746" modified="2020-04-22" version="1">MTKKRIFFTGGSGKAGKHVIPYLLDQGHRVLNVDLRPLDHPGVDNLIADITDSGQMFNAMSSYAGLDELEPGGGVPKFDAVVHFAAVPRILIHPDNETFRVNTMGTYHVIEAAVKLGIEKIVIASSETTYGVCFSDGQTNPHSLPLDEDYDVDPMDSYGLSKVVNEKTARAFQRRSGFDIYALRIGNVIEPHEYAELFPAYLKKPEVRRRNAFCYIDARDLGQIVDLCLKKDGLGYQVFNAGNDHNGAIIPSKELAERFFPGVPVTRELVGHEALFSNRKIREVLGFKEQHHWQKYLKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5W9</accession>
    <name>A0A654E5W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Autoinducer kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_90044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="406"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="663"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="810"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="913" mass="102963" checksum="7DE45A693330705F" modified="2020-04-22" version="1">MKYSFQTIVFLLSALLWACKPQITDKKYLVGFSQCTSFDSWRKTMQSEMQRELSFHGDMQLVIKDAQGDNDAQNKHINELVEMGVDLLIISPNEAEPVTRSVDQAYRSGIPVILIDRKTNSNFYTAYVGANNYKIGKIAATYIASLLDGQGKVLEIKGLKGSTPFIERHNGFRDQIKTFPQIEVTEIEGEWGGEETARKRFVELMKGGNSFDLAFAHNDIMAYAAYESYRELSPGGSLEIIGVDALSGPGGGIDYVTSGILKASLLYPTGGDVAIQIASDILHGRPYDKDNELVTTVIDSSNVHVMRMQTNKILAHESDINRLAERIDQQRVVYKNQQYILYVIAVLFVISALSFAFTLKLLRERREINKSLKKRNEEVSRQKAEVMEMSQQVNKANQSKIQFFANISHELKTPLTLIQGPLDELHSSNTLTGFMKKDLELAQRNVRRLTGLVNQLMDFQKIENGRMKVRASKTELVGFLKEITDSFRNLAKKGRYTLIFDSREDRIDLWVDKTMIDKVFFNLLSNAFKFTPPGGTIKVILLPVPEKNEVVIQLTDTGMGMSKDQRARAFDRYYQGDDSRADGTGLGLALSRELIAMHDGTIEISSQKDVGTTFEVRLKMGDSHFSEEQLSSDGDQLVNDHEIEDGFGYEEGVEASMADHEFTVLIIEDNQELAAFLKRKLAESYKVLWAKDGEAGVTLAKEQIPDLILSDLMLPKLGGRDILAKMKSDVRTAHIPFIIMTASSSEEERVEGVREGADDYITKPFSFRFLSERIKTTLANRAKLREHYLHEIPSDQSQRSEGKLNKKFVNDFTAVVEQNIADQSLDVNVICESLGLSRIQLYRKVKAMLGYSVNDYITTVRLKKAKYLLSTTDKSIGEICYEVGFSSPSYFSSTFKSKFDISPSEYRQNRANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E640</accession>
    <name>A0A654E640_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043772">
        <property type="entry name" value="MBG_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18887">
        <property type="entry name" value="MBG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="171"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="255"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="348"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="423"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="751" mass="76122" checksum="81660162286919FB" modified="2020-04-22" version="1">MDVQQTLTIEKASQAITFEALADKTYGDAAFDLTATGGASGHEVTFTSSDETVASISGSTVTIVGAGTATITASQAGNDNYSAALDVQQTLTIEKASQAITFEALADKTYGDAAFDLTATGGASGHAVTFTSSDETVASISGSTVTIVGAGTATITANQAGNDNYSAALDVQQTLTIEKASQAITFEALADKTYGDAAFDLTATGGSSGHVVTFTSSDETVASVSGSTVTIVGAGTATITASQAGNDNYSAALDVQQTLTIEKASQAITFEALADKTYGDAAFDLTATGGASGHEVTFTSSDETVASISGSTVTIVGAGTATITASQAGNDNYSAALDVQQTLTIEKASQAITFETLTDKTYGDADFDLTATGGASGHEVTFTSSDETVASISGSTVTIVGAGTATITASQAGNENYSAALDVTQSLTIEKASQAITFEALADKTYGDAPFDLTATGGGSGYAVTFTSSDETVASVSGSTVTIVGAGTATITASQSGNDNYSAALDVSQSLMIGQASLMVSAGDEFRVYGEVNPGFTIGYQGFIGDDSEADLETIPTASTLATQTSDVGTYAITVSGGVAQNYAFTYTDGTLTINKAQATVTLENLTQPADGTAKSPTVTTNPAALAYSMTFDGSSTLPTQAGTYVVEVTLLETNYEGSVTGNFVLTKAVALGALPLVNEVKVYPNPAAERLTVSGDDGLLVKIYDISGVLLLEDEINQTIAIDRLRAGVYLLQVSDANGRVVSHQRVVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6S4</accession>
    <name>A0A654E6S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="14753" checksum="DCD810AC19DF7582" modified="2020-04-22" version="1">MFGDKPRQMKTKILMTLSAVTLALAGIALTFAPEEILLSISAEGTPTLTLVLQLLGALYFGFGMLNWMTKTARIGGIYNRPVAVANSSHYAIAALALMKSLTGNSDLPAIIWVVAIVYAVFATAFGALLFWSPVKSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E774</accession>
    <name>A0A654E774_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="13560" checksum="96236EC245880ADE" modified="2020-04-22" version="1">MSNKISQYLENMEGEPTAHLSGFKKVFLTCDDTDSAITQFAYASFMPGEKCENHVHPTMMECFYFISGFGVYKVGGELVRIKPGTFLRIPPNTPHEFRNDSIENLEFVYFGIAIENSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAK1</accession>
    <name>A0A654EAK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rplR</name>
        <name evidence="8" type="ORF">MARINOS108_120481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="12610" checksum="4D05190DE4217637" modified="2020-04-22" version="1">MAVTKLERRKRIKLGIRRKISGTGTRPRVSVFRSNKAIYGQIIDDVKGVTLAYASSLELGKEQINVEVSKEVGKKLAEKASAAGIQSVIFDRNGYPYHGKVKAFAEGAREGGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDH1</accession>
    <name>A0A654EDH1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferritin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="17438" checksum="F2CD40F5BEC52E41" modified="2020-04-22" version="1">MNSEKLIIELNQLLSDFHIYYQNTRGFHWNIKGKRFFELHVKFEELYTEALTSIDEIAERILTIGGTPLHAFDDYLSTSKLRVHKNVSLDTATVTAIHEQLSQLVDQENVVKALAVECGDNETEDMMIALINTQQKTMWMFKSWLGEEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEM5</accession>
    <name>A0A654EEM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na(+)-linked D-alanine glycine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dagA</name>
        <name evidence="9" type="ORF">MARINOS108_50075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="585" mass="63998" checksum="A9ED1B2AA8CE0C19" modified="2020-04-22" version="1">MSDYQFYNLFPFMLQINEFLSLIDSFIGGAVWFPYALLGTGLFFTIYLKFPQVRFFRHALRIVSGKFDRKDLPGDTSHFQALSTALSGTVGTGNIAGVAFAVHLGGPAALFWMLVTAALGMCTKFVEVSLSHKYRNKLDDGTMAGGPMYYMKNADFKIGGKKVNLKWLATIFAVATVLSSFGTGSLPQINSISSTMLSTFGVNQMLTGAVLAICLGLVIIGGIKRIAAVTSKLVPGMAIVYFIGAFAVIFFNIENIIPSFVSIFSDIFTGTAATGGFIGANLAFAFNRGVNRGLFSNEAGQGSAPIAHASAKANEPLSEGMVAILEPFIDTIIICLVTGLVLLSSGVWSEKHNNQFEYAEIEILNDSYKESNPDNSKTIYDHLNGIKALPVYTGALNVVDGKIQNEDITFLHSRSFAENVMVYKNEGLLTDEVFTGSVEIVNGTVTDSKPLKFIGESLVHSAPLTAIAFNRGFFGDYGQYIVSIGLLLFAFSTAISWSYYGDRAMTFLFGSKSVIYYRIVYVIAFFFAAFQDTTIIWTLSGITIALMTIPNLIGIIWLRKDMKQTIKEYGEFFEKTFPGEKHPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSD2</accession>
    <name>A0A654DSD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_10002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="291"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="779"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="849"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1332" mass="152457" checksum="3C589DDF6EEF6ED4" modified="2020-04-22" version="1">MRIPEIPANEQSRLEALRELEILDTLPEEEFDNITKLASEICQVPISLITFIDEGRQWFKSHHGLDVEYTSREVAYCAHAINDPKEILEVHDAYEDERFHDNPLAVGEPLVRFYAGVPLVDPEGHALGTLCVIDHKPNQLSIGQKEALRTLAQHVMAILNVRSKNIELIKSQQKFQDLVNHMDDMIYELDSNGYFKFSNIKLQKLSGYSDQELSQMSYLTLVKENARSEMIAFYNEQRTKKQSKSYYEFPMITRQGEERMIGQNVVIDFDQHGKLSRVMAVARDVTELHEQQRVFRLLSENSKDLICLHEPDGTYIYVSSSVKDLLGFDQEEMIGRNPYDFMHPEDRDRLRENPHAQTLKGKEIGGVQYRMKTSAGNYLWLESYTKPIVIDGEVVSFQTSSRDISKRRFNELQVQKSKENIEALIENTEDAIWSVDRKFRYKIANGAYKALIKWLVGREPEIGESGLDVGDKMFQDLLQHYRKSLDGKKFNIEYQLTHNGVRRYFQKFFNPIRNQEGIITGVSVFARDISYEKKILRNADRYREGLQLLNIIFSNTSLTMDQQIGEALKISCEYLKMPSGIIGQVEKGFVTIKKYYSSEPVPIKEGDRFPFENTFSQLIYDYGRTLAIENVSQSDFKEVSSFKAFKVSSFIGASISVNGVRYGTISFGSTEQRGEFFDSNETDFVDILAGWIGFNIEKQLYEKRLRSEQDVLRAFVHSAPAAIAMLDENLTYLAVSSQWKVDYQLGDRDLIGANHYEIFNNIPDSWKEAYESGLQGKESRKERELFEMGGQTRWLKWEVRPWYTSNKEIGGIIVFTEDITRQITQEEELKLAKNEAEKASQAKEFFLSSMSHEIRTPMNAIIGISNIMLYENPRADQLENLKLLKFSSSNLLVLINDILDFNKIEAGKMELELIDFNLKEVAMNVYQTMLIRANEKGLVFLFDYQNGLPENFVGDSVRITQILTNLLGNAIKFTEEGIVKFKIEEKKRLGKEVILGFTVTDTGIGIPKDKIDAIFENFTQASTNVARKFGGTGLGLAITRELLKIMGSDVTVESEEGEGSVFTFDLKLPIGSLKSLQQDYSEISAVAPESSNTGIRLLVAEDHKTNREILAKFLDRWGFKYDFAENGLEAIQMASKKNYSMILMDIQMPVMDGFEATREIRKMKNPQLKDIPIYALTASVLLGVQEKAITAGMSGYISKPFDPDELYAKITSESIRLEYETPVVTRDVLSHEAITQMSLGDEEFKEELYRYYSSEFHRLLGDLHSALEQEDRDMRHASIEELTKLNKGEIMPDLTPLLQALNDEQSAADLKRIPAALYELIHTLTARHDRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT90</accession>
    <name>A0A654DT90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="30078" checksum="174E570F83094F91" modified="2020-04-22" version="1">MPQSILPDRIQIIHMKPLHFIFTFMALLAFSCERTSNFNDKLLKQLAELNSNRINNFIETTEQMGVPYAGVKRMDLFLSDWHKVIKEHLSLDSIPTATINDHINRLEKQRWDDDADVLIDLFKRNLDKSDVTSVVLNEIELLDRSLELLNSNFRLFDIALPVVVGDRNLKLNQTDTLKFVFQGVSRYLRNIVYFGKIDELMESTEGIEEATEFSNKLFANYHVIKATERGQHELTGVMVMFDRGEELKLPFRYVYTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTJ6</accession>
    <name>A0A654DTJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_23" evidence="1">
        <location>
            <begin position="97"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="26671" checksum="19151F3B6AE7FB85" modified="2020-04-22" version="1">MLQVYPFMEKTATKTRKKSLSQEDFKLAYMDHVLTHGSNPASVFAFAKDLKSTEAQFYSYFNSFKALERTIWSDWFAQTIKTIEEDPAYAEYTVREKLLGFYFTWLEILKNNRSFVLKRFEEISRKELNPYFLEGVQPHFKSYVNDLVTEGKDTTEVAERPFTNQYEKAFWLHFLFITRFWVNDDSSDFEKTDAAIEKSVNLAFDLVGKGPLDSMLDFAKFLFQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTW7</accession>
    <name>A0A654DTW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="349" mass="39957" checksum="108BEEC20508E632" modified="2020-04-22" version="1">MSHPVLRGSGNKVYLLVWVLMVFLHGTVLYFYYGWSLEISAADSLVYNLLFASIAPGFWYIVTFASLSKDDLALVGTHLAGATMAIFLWAALSGVALRFLFPDHQEYMAFLKRAYIWRLIIGVMYYSITVLVFYLIKYYQDLQERTHRELELQNLLKDSELRMLKSQINPHFIFNSLNSVSALTVSKPEAAREMVIKLSDFLRYSLGKDSVHMNTLAQELDNATLYMDIEKIRFGSRLRFEKEVDDACLKVNVPNLILQPIFENAIKYGVHESIHEVTIRLKCVGHPGMLEIHIGNNFDEESMPSKGAGIGLENVRRRLGLVYGRNDLLEVDQQDGEFMVKIKIPTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU05</accession>
    <name>A0A654DU05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhbW</name>
        <name evidence="3" type="ORF">MARINOS108_10193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="37871" checksum="6514A43823FA8AC9" modified="2020-04-22" version="1">MNYLHLLFVVFTDMKKTFGNIPLSVLDLAVILEGNTPADSFRYSMRLAQKTEALGYLRYWFAEHHNMASIASAATSVLIGHIAGGTSTIRVGSGGIMLPNHSPLVIAEQFGTLASLYPGRIDLGLGRAPGSDQATARALQRDPTAAYRFPDTVQELQQYLSADNKNAAVRAIPGEGIDIPIWILGSSTDSAHLAANLGLPYAFASHFAPQQLHDAFRIYHQEFTPSAQLSAPYTMACVNVTAADTLKEAQLIATSMQKIFLGILTNDRKPLQPPDASFVLSQEIAQVMKQFLTYSFVGGPEEIRTGISKFVDDTQVDELMVVSHIYDLEARLRSYEILKELHLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUA4</accession>
    <name>A0A654DUA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="319" mass="35974" checksum="C810A601D0B2C442" modified="2020-04-22" version="1">MKFDFYVYSPILGIILAPTCIRSQIQKNLERLSQNLHEKMNSKTPIFLTLAATFLSFTTSFGQKNSQSGEFNPKNDLLLVQFDCKTDVDDLHTVAALATLLTDSNYSTLNYHAIAGTYGIQEGLYVPPNDLFQLAFGNNWTDAHNKSEAAVEKVKLIVQATLNRQGDIWIAEAGQSDFTALLIKAIQKDLPQIKTAQRIHVVQHSDWNENSTSPERLQFVKENAHYQKIPDGNAVGNGTPGFRDPEFTSWKEEIKDPNLFKIWQLSTDLSNQYNGKDGRYNNEAVAAGGLDFSDLSEVCWILGLQDIRDTEHFFRLYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUC7</accession>
    <name>A0A654DUC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="30958" checksum="7C03726EE51D1CBA" modified="2020-04-22" version="1">MESAVNFLSFISLIYVILPILFLIGLGIYLAAGKPVPSSGYEKIIEISKWYIVSVALVFSGNLVKDGFTERETGIKEMQVYDKYVDLILEADNIEKRWKLAEYFATVTPTDRLRERWVEYQGKLQDDYDEYKKLLADEQKLEKLDTSATDPESALEIIQRQKAVYERPLVSKEPTPFRVDIFYLEETMASRDSKGKANQLAQQLASTGYLVKVKKLTTAKNAEAGYRVKNNQIRSEASELDVASGVNALIGGEYEIITISYKTPNYISVFVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVE3</accession>
    <name>A0A654DVE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15497" checksum="CA1F81EC85B64635" modified="2020-04-22" version="1">MKTTKPTATELYYQKIAGPLYPFCDNALVHFKDIGGGKKKAFINAYLPTLVEDKITVSIHDEQQIRNTEVERQLSKGPLIGTLITLTYKSQKGTGSYYLWQIAFTYESKYPVGVEDVVLVDTDPETSRGTVTTVKDPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK1</accession>
    <name>A0A654DVK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="27129" checksum="A16A74D04C69AC51" modified="2020-04-22" version="1">MPVETEETLSIIKVSIFKFAENIQISVAKERILEGAHSLFMQYGVRSVSMDDVARELAMSKKTLYLHFSNKDELVTEVVRFHMDGEMAEFGRVIESAVNAVDEIFKLAKCMREHAFRVNPSLLYDLHKYHAEAWAIFQEFKSEYLVGQIIDNIERGKQEGYYRLELNARVLAILRMEIVQMVFSDQVFPRSEFDFIEVQMQVFDHFVHGLLSEKGKQLYQEYQSQEVNNHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP8</accession>
    <name>A0A654DVP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="25801" checksum="DEB60DF77B6F63EB" modified="2020-04-22" version="1">MNINTTFLVTVALLGLHFGQPLPDVYCRTTRHCANSVISWELADMIRTKPNDLRIVGLPGIVETPFGQSVYFDGVDDALFLEDMPLDSMESFTIEMIFYPDTAGPFEQRVVHIGEVFEDRMLLEIRAVDDQWYFDGFVSSAGNNKALIDENLTHPLGQWYHVAFVVSDSSLDTYVNGSHELHEPFTFKGIQTGKCAIGVRLNEVSWFKGIIHEIRITPGQLDPSAFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ2</accession>
    <name>A0A654DVQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018821">
        <property type="entry name" value="DUF294_put_nucleoTrafse_sb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10335">
        <property type="entry name" value="DUF294_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="636" mass="73099" checksum="99CA7B3450EA4908" modified="2020-04-22" version="1">MVSMSDKLSFLKNTHPFDLLPDDALSHLADALEEIEFGQSGIIHEQHKTKVDGLEIIVMGQYETYFYNSEGKKEASSNLGPGDTYGAFSILLNKGKSIKTVFAAKKTKIYRAPTATFRTLCKEHDAFYQSFVTLFGREMLNDAFANFVTRPSYDLDTLTFDRYFIGRMDSVNTRPIVSCERGTPVHEAAKLMEANKLSCLFVRDDDDFIGYVTDILLRNKIIAAQRDANTPVEEIMEGPIYRISREAYIYEAILMMFNHKIRYLIVEDHGQETGVISRSKLLSDQAQSPFVFIQSVRLAMSVDELKAKWAEVPEVVYNLLTRGVKSELANQIITNISDTIAQKVIEGVIAEIGPPPAKFVFMALGSEGRMEQTLKTDQDNAIIYEDKANEFREITRTYFLHFAELVSERLNHIGFVFCTGGLMAKNPKWTHSLSHWKRNYNEWIENPDSQSVMNFSTFFDCRFIYGEESLVKELQAHILQKLEDPGTYFFTQLATNALQYEPPLTFFRGIKTIEKDDQQVFNIKRSMTPIVDLVRVYALKHKILKTNTGERLSALRDQKVFTEEAYHELMQSYYYMMGMRLRYQARQIMNDHTEPHNYVSPGSLTKIEVVTLKAIFKVIENFQQGIKINFTRNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX7</accession>
    <name>A0A654DVX7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">MARINOS108_10873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="19996" checksum="20C246B10E175740" modified="2020-04-22" version="1">MEKITLGSGCFWCTEAVFQRLNGVESAVSGYSGGKTKDPFYKEVTTGRTGHAEVVQVTFDPAVISLEEILEVFWKTHDPTTLNRQGNDVGTQYRSAIFYHDSAQKEVAERLKKALDESGAWGDPIVTEITPFEVFYSAENYHQDYFNENGSQPYCQFVVAPKVKKFKEVFADKLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY8</accession>
    <name>A0A654DVY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pycA</name>
        <name evidence="8" type="ORF">MARINOS108_10883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="2"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="497" mass="55264" checksum="F8C039EA457FEB81" modified="2020-04-22" version="1">MKIKKILIANRGEIAIRVMRSAKEMGIKTVAVYSEADKAAAHVLYADEAVLIGPPPSAQSYLVADKIIEACKLTGADAVHPGYGFLSENAQFAEKIAQAGIIFIGPSVEAIKVMGDKLASKQAVKSFDVPLVPGMDEPISDVEKAKAVAQKIGYPVMIKASAGGGGKGMRIVTDPKDFDEQMTRAVSEARSSFGDEAVFIEKFITSPKHIEVQILGDQYGNIVYLFERECSIQRRNQKVIEEAPSAVLSPEQRKRYGEAAVNVARSCNYYGAGTVEFIADAHLDFYFLEMNTRLQVEHPVTEQISGVDLVKEQIKIAQGEAISFTQEDLQINGHSIEVRVYAEDPENNFLPDTGTLSTYRRPQGAGVRVDDGYEEGMEIPIHYDPMIAKLITHGKDRAEAIERMKRAIFEYKIIGIKTTLPFCEFVLNHPDFIDGSFTTKFVEEHFTPDHVRKEPSEDLERVAAIFAFEQYKAKKERLQYTPAASQKSGWKSRIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW25</accession>
    <name>A0A654DW25_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ORF">MARINOS108_11195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="25345" checksum="7717CAE50D0B5507" modified="2020-04-22" version="1">MEISEIKAKLESYKAEGKKMFTTSSFQTHSLVMLHILSRIDNTIPVYFLNTGYHFPETVSFKDQVTEAFGLNVIETRSSVPRYMQKDHSGKLLFTSDPDHCCYINKTAPTEELLRTYDIWINGVRGDQSSTRKAMKTEQEAPFDTIRFHPMLDWNMKTIFAYIREHNLPRHPLDSKGYLSIGCEPCTRKLDPEMQEREARWFGLNKVECGLHTDLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI3</accession>
    <name>A0A654DWI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="20027" checksum="D6B9E506E6613992" modified="2020-04-22" version="1">MMVGIDLVDLSDPLLKPRDHRALRLISHPDDHVPDHPHSFWLLWTAKEAVFKAQRQIIPFDPKKIAVSISQSDNTLSFQSEILRGNIFQDQSIIYAIVHSENQPCHHQILKRNTQSPSEEVRAMVIQFIKLHHQIQVAVRTDEKNLPVLSHQQLPISFTHHHDYLGFILPKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR6</accession>
    <name>A0A654DWR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase RhlE</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rhlE</name>
        <name evidence="10" type="ORF">MARINOS108_11150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="51169" checksum="53B6E5BEDDC0A2C2" modified="2020-04-22" version="1">MNTFEILNLSKPLRQAIDDLGFERPTPIQEQAYPVILSGKDIIGIAQTGTGKTLAYMLPILKDLKFSEQVNPRVLVLVPTRELVLQVVDQIEQMAAYMSVRVLGVYGGTNINTQKITALQGADIVVATPGRLYDLVLSRALQLKEVKKLVIDEVDVMLDLGFRFQLTNIMELLPERRQNIMFSATMTEDVEVLINDFFSAPVKISIAVSGTPLDNISQEYYPVKNFYTKVNLLLHLLRDRETFHKVLVFVSNKKSADRLFLAMEGIYGSETCIIHSNKSQNYRIRSIRQFDEGKNRILVATDVMARGLDMAKVSHVINFDTPAYPENYIHRIGRTGRAEEEGKTILFCTEKETPFREAIEYLMAYEIPRLEFPEEVEVSTELAPEERPKNKEINAHHKVPDPDAPGPAFHEKKAKNRKTNLGGSYRREVGKKYKKPRTRGDKNQKGKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW9</accession>
    <name>A0A654DWW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nucleotidyltransferase with HDIG domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="187"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="263"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="477" mass="54172" checksum="F5B5300567CF8144" modified="2020-04-22" version="1">MMVTEVLDKQVDFHPLIHRVGQVATGLGVSAYIVGGYVRDLILGRNSKDIDFVCLGSGIRLAEQLKKELGKEAKLAVYKNFGTAAITYGGYELEFVGARKESYRADSRKPIVEDGTLEDDQNRRDFTINALAISLNEHDFGTLIDPFGGVEHLGQKLIKTPLEPEVTFSDDPLRIMRAIRFATQLKFDIDPDTFNAIVTQKERIKIISQERITDELNKIILADTPSYGFKLLFSSGLLEIIFPEMARLQGVKKVNGKSHKDNFYHTLQVLDNISEDTDDLWLRWSAILHDIAKPATQRFHDKAGWTFHGHEDMGARWVPKIFKNLKLPLNDKMKYVQKLVRLHLRPIALVNEKVTDSAIRRLLYEAGDDIEDLMTLCRADVTSKNMDRVRRYLANFINVQNKIREVEERDHLRNFQPPVSGETIIETFDIKPSVIVGEIKNAIKEAILEGQIKNDPAEAYDLMLEIGKAKGLTVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX33</accession>
    <name>A0A654DX33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="104" mass="11562" checksum="AA4F7213CAE65AA5" modified="2020-04-22" version="1">MRAFRVTLQAVSGSLTKYRSTCLDSFLLVSGFPIVYLWIMSSIVINPKSSEELKFISELLNKLGVKSKVLSDEDTEDLGLSLLMKDVDRTDIASDDEVMAKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX58</accession>
    <name>A0A654DX58_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">acpP</name>
        <name evidence="11" type="ORF">MARINOS108_10143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="78" mass="8596" checksum="5F94DDE2E9A9D54B" modified="2020-04-22" version="1">MSEIAQKVKSIIIDKLGVEESEVTTEASFTNDLGADSLDTVELIMEFEKEFNISIPDDQAENIATVGQAISYLEENVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX83</accession>
    <name>A0A654DX83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="421"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="597" mass="67491" checksum="C8854C62423790AD" modified="2020-04-22" version="1">MPAAIFQGRITHFEQQFTRHSDLATRYSLLRAITFLAGAVCFVLLLNKDHWMFVPLLFMALVGFIFFVTRYQFHEGKKAFFTQLILINREEIDRLNLHLSGFRTGDEYAQKDHPYQADLDVLGQHSLFQLLNRSALPDAEKMLVQWLSEPAEARTITRRQEAIRELSQKVDWFQHFRAAARVAVNQKSKEAPHTNASHLYHWASKQLMLRQSLWKMASIILVVISLALGACILLQWLPYQVIYISIILNGGLLALVIKKLNHQIAGIDKAHYMVSTYSHMISEMEKQTFTSEELCHLQSQLTTPNSASLAIKKLSNLTLRISARGNMFYMIADFLLILDAFLLLDILKWKKANADHMNEWLEAVHQLECLISTAAFAHANPQYVFPEVTLAKQSLKASDMGHPLVSAAEMVTNDYEISGSGSVDIITGSNMSGKSTFQRTLGINMVLAGAGAPVFASAFTFTPCRIFTSMRTKDNLEEHTSSFYAELKRIAQLLDLTKRGEVVFFLLDEILKGTNSQDRHTGAVALVKKLTKTEAFGLISTHDLSLGQLEETEPKVRNYSFNSSIEGDRIIFDYHLSKGVCRSFNASQLMRNMGIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX99</accession>
    <name>A0A654DX99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SM-20-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P4Hc" evidence="4">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="23989" checksum="45900270C6ABBC2A" modified="2020-04-22" version="1">MTNDLVLTEEEARFEALIQGLLSEGHGTCADFIDSLTANGLRSNLLGHKQSGDMRPAGISRQFDYQRNAEVRGDVIRWIENDTSDVFELLVLSRIQAFITYLNRTCYTAINDFEFHYAYYEQGSFYKRHLDQFKSDKGRKYSLVMYLNEDWLESDGGQLSLYHPDGTQENVLPVSGRAVFFESDKVEHEVHPSLNRYRLSIAGWLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA5</accession>
    <name>A0A654DXA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="277"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="490" mass="56128" checksum="3EC8C77E82B58A84" modified="2020-04-22" version="1">MNNIKSVSHHHLSMLESFPCATVVIDDKGEIHYANHQVRELFGHDPNGLVGQTLETLIPPKFGKSQIDNLVSDIRDQPLSQLKNTVLHGNHIDGQEFPVKVKLTTLPIEFGGLVAAVISDESRKVNIENELIRKNHLLNFAEEIVGMGHWQWDLRTNDVIWSDNLYKVFGRNEEGGLKYDTYFSYVHPDDIEYVTERVQTSIADKKFHHFFHKILLRDGRVKTIHLVGQIFTNDNDEVIEMVGTCQDVTENLKNEELLRNASILEAKSTEMEQFAYIASHDLRHPLLTIINYIKAFDEDFGHSLTDEAKEYLNSISQSADRMDKLITGLLEYARLSQKKQRETVDCNEVVKDVIKDLSATIEKQDARIITDPLPVIDGYEMEMHQLFQNIILNAIKFRKKKITPVIHIKSQKMETGEGYLFEINDNGIGIPEKDLGKIFSIFRRLHENEEFEGYGLGLANCKKIVELHHGKIWAQSEVGIGSSFYFTIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD3</accession>
    <name>A0A654DXD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="305" mass="33526" checksum="289D015B663C80F7" modified="2020-04-22" version="1">MMYSIGVDIGGSHITSGMFEHMNKQLMKNTIVTLPVDNGASKSEILSQWTEAIQRTMSISGVAHVEGIGLAVPGPFDYYNGICLIKGVQKFDSLYEVNIREELSSRLNLPGDKIRFINDAASFSIGEAKFGEASTFRRCVAITLGTGFGSCFLIDGQPIVNGPNVPEQGVLYDKYFDGHMADDLFSTRGLINSFNQLTGKKVDSVLDIYQMAKENTTAYEVFQDFGSELGKFLKPHLSLFNAEVLILGGNISKAFEYFGDKLQEQLPEIKITVSKLNENAALIGGVSLFEKGYYSELSTTLKLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP6</accession>
    <name>A0A654DXP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="28738" checksum="40686EBF2BA52FCC" modified="2020-04-22" version="1">MPINTRNSTVSRRNEILNAINSEGQVYVDELSAKFGVSEVTIRNDLDQLEQKSLLIRARGGAMKIEGRVGVDYNLSEKDKINYQEKVRIGRAAAKLIKNSEIVLIDSGTTTAEMVKNLTEIEDLTVITNALNIATLLISHPGVNLTIPGGYLRKNSQSLVGPLAERSLKNFYVDKAFLGVDGFDTKTGLYTPNIEEAHINELMIEIANEVILLADSSKFKKKSFAFICPIDKIDIVVTDDKLSDDDRKRLEDAGVKVIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ3</accession>
    <name>A0A654DXQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="14911" checksum="E3B32025CA65F507" modified="2020-04-22" version="1">MVELSLEYWNKLSSQFILMSVFLGGFSIALTANLLISKSETRLLNIILKLATTSSAGFLTTVFAMTNILMRTTDGYPGAIAESGLNTPRIIGFLGYIVGVFSLLTIIGLSGWTKSKGTGIFTTVVSVITLIFFLISAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR0</accession>
    <name>A0A654DXR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="22585" checksum="44677C6CCD0A0418" modified="2020-04-22" version="1">MKITLTDLGKKYNREWVFRHLNFEINPGDTIAITGHNGSGKSTLLKVLGGYLTPSQGKVTYGDNREHIQTQFSFAAPYLNLLEEFTLKEHLAFHSKFKKALCPHEEMLSLSNLTGAEDKLVKDFSSGMKQRLRLVLAFFYESSLLLLDEPTSNLDQDGTDWYLSMLQKVSDEQTMIIASNQPQEYAGANQIISIENFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU5</accession>
    <name>A0A654DXU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="17223" checksum="16D3FC5C64278CC0" modified="2020-04-22" version="1">MKRITQLLTALVFCSLIVFVSCKKKKKSEKDDPRDAVGMALSKTWSPTSVTKDTENRTEWDGFTIGFTYNSETDIGGYSVSGVPSNEGASDVWGSGLSWTFDGEDESADTGTILRSDGVTVQATLDNPDAPTTLTLSFTITDASARAAGFNGAWIFTLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW8</accession>
    <name>A0A654DXW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate/guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="484"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="590" mass="67281" checksum="19F1DC9660FEEA56" modified="2020-04-22" version="1">MNDQKSIAVLPFRDLSVDGSNEFICDGISEEIINALAKIDGLKVISRTSSFFFKNHKASLDEIATKLGVAILLEGSAQIHDGKIRVRAKLIDVEEDTHFWSETWDRKLENLFETQDEISLLIADKIREQYGHLNISSQLVNSPTKSVSSYEHLLKGRHHFYKWNPEDTHLAIEHFEKSIALDEELVEGYLGIADSYSFMAVAGFAPREEAWQKSIAAIASAKNLDPDHAGLNYMLGMQYFFTEADFARAMQYGMRSLAAKPTYSEAHQFVSFLHSIKGDFKKAWEHIHYAKSIDPLNPETKFYEANYYYRVGENDKAKEILNELLEANDKNLPAILVNIYILIQERQLELACQTIDKIPEQALTPDERLGLFALIDAKDGKSTTHLQKLEKHAQEPEAHHAHAYLFLTYANLGRYDDAFSVLEKLFESTSSILLLAFSDPLGVPIHSESRYLEFHARVYPKIGEKTKVKKARQSDHTIAKEQVEKIQTYVESERPYLNPSLTLRSLAEHVEIHPNQLSWLLNESIGKNFNEFINHKRIEHFKQLVLDPDNSHISLIGLAYESGFNSKTVFNTAFKKEVGMTPKAFQKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY40</accession>
    <name>A0A654DY40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="13729" checksum="CC73B435889D8EA8" modified="2020-04-22" version="1">MTKTCIRVYADVDQINQCKQDIEKVEESVSRLAKALNLAGNEVRLKILFLLEKESKMCPCDLSDILNMTVPAISQHLRKLKDAGLVETKKVGQTIFYSISESNTNILNPIFKLLESEKVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY92</accession>
    <name>A0A654DY92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zeta toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21183" checksum="785223F072344B38" modified="2020-04-22" version="1">MYIIAGPNGAGKTTLSYTILPEIFECDEFVNADEIARGISPFNPERAGIRAGRIMLDRIKELVSKGESFAFETTLSTKSYRSFIKKAMSSGYDTTLLFLALDSIELAKQRVKTRVLEGGHNIPIDTIERRYSNGLSNFFKIYRSLVNRWILVDNSTENFEFIAEGSGTDVIIRSETKWSQLKDAYNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ01</accession>
    <name>A0A654DZ01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8389" checksum="EA3CB482C500963E" modified="2020-04-22" version="1">MTPGSGRHIGLRSDNGPEYFKNGSWTLKIHLLNHKLWAMADNSYRFLAIRPIIVPTVLMQCSLGFCVKCWLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ48</accession>
    <name>A0A654DZ48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplT</name>
        <name evidence="7" type="ORF">MARINOS108_10861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="13401" checksum="6B03642E1D04A7DD" modified="2020-04-22" version="1">MRSVNHVASRARRKKTMKQAKGYWGRRKNVWTVAKNAIEKGMQYAYRDRKVKKREYRALWIQRINAAVREYDLSYSQFMGQLKAANVEINRKVLADLAMNHPDAFKAVVDLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ51</accession>
    <name>A0A654DZ51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="431" mass="49868" checksum="F56E078BB1D9DD63" modified="2020-04-22" version="1">MRLLAIANRYYLATLIIVFVAGSLAAYLILKSIINQEFNEKLFAEQDQLLYELRNYENLEKTYYLNIGDLIEINEVAENPNIPPTLIDTVMYDPYEKKELPFRLLTFSSEIKSRFYVITISKSLLPNQDLMEGVSEIMLGIALMLMVSLGLLNRFIFKKLWHPFHQIIDQLHKFQITHPEQLAIEPSHVEEFNDLRQVLDKMISKSIYDYKTLKEYTENTSHEIQTPLAIIKNKAEMLLQEPLSEAQLNEVSKIYEAAGRLSRLKEGLSTLTKIDNNQFVESEPIELKAFIMSRLSGFDELVDLKGLKVDLRFEGNPILNFSNDLMYMMITNLLSNSIKHNIQDGTIRIILTQNHLVIENTGKDPGLPTASLFDRFKRSGEGHESTGLGLSIIKRIADLYDMTILYTYQDGWHRIKISFNSQKHQNHEDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ52</accession>
    <name>A0A654DZ52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusC/RagA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025005482" evidence="5">
        <location>
            <begin position="29"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="123"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="375"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109778" checksum="4B55D68D9F384B19" modified="2020-04-22" version="1">MRRLLLLKIKSKYVALLAMCFVSYLASAQMTVSGVVASAEDGLGIPGATVLEKGTSNGTITDVDGRYSITVSDPQTAVLRVSFVGYVNTEVQVAGRSEIDVSIEMDLQQLNEIVVVGYGSVRKSDNTGALSSIKSEELNAFPALSAVQTLQGRAAGVQIQSTNGGEPGANFSLKIRGGSSINASSEPLRVVDGFVGGEMPPPQDIQSMEILKDASATAIYGSRAANGVLLITTKSGGEGKMKVDFNSSYSYQEASDRLDLLSGEDFRDYILEVLPNYDYNPDVDTDWQDEILRSGHIWNNQVSVSGGSPSSKYYISATHFEQEGVVVNSDYERYSITSNLSFTASDRVNLGVNLYGRRSIQNGVLTQETTGGSSNTGVLGAAARLEPDTPVRDADGNYTQSKLGDNIDNPVAIANGIDRERITDRFQVNSFAEVKILDWLSFKSTLGAGVTSYREGTFTSSQLGRGGNGGIGTLEFDKAINLLTENYFTVKKDFDGHRINWVNGYSYQKSQDEDLLATSSDFVSEAVSYWNLGGGATWPAPNSGTSTRILKSYYSRLNYTLFDRYVFTVTGRYDGASNFAANNKWAFFPSGAIAWNIGDEAFMKNLNPIYSMKLRTSYGLTGNQAIGAYGSLATLRSQYSIRPGEGAFILGTLANPNLTWETTSQLNVGLDVGLIDDRINFTVDYYNKLTSDLLFDRPIPSFLGVAGTATQIQNAGEVRNKGLEAAITTRNIQRADFSWTSNFVFSMNRNEIVSLADTVGIRYEDAPGHFNIATGFQLLEIGQPVGVYYGFVYEGVTQPGDPLLEGSDGKIGGEQFADLNDDGILNDDDRKIIGNPHPDFVWSMNNNFTYKNFDLNIFLQGVHGNDMMNLTRMELESFRGTWNVSTAALDRYHPIDNAKGTIPSADTDRTLKVTSRWIEDGSYVRVKNIALGYNVPSSLLDKINVRSLRFYVSAQNLLTFTDYSGLDPETAYNNSTSNADSNRNLGLDYGSYPNVKTYTVGLNLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ74</accession>
    <name>A0A654DZ74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="29754" checksum="A9B7B29D2D836722" modified="2020-04-22" version="1">MKTIFITGASRGFGRLWTEALLQRGDRVIATSRDITSFNELKAQYSDAFVPLSLDITDRNAVFETVKEAHARWGVLDVVINNAGYGVFGATEELSEKDAKEVVDVNLFGTLWVTQAVLPLFRAQGNGHLIQLSSVLGLWTLPTLGLYSATKFAVEGLSEALAQEVERFGLHVTLVEPNGYATSFAGDSAVLSQPISDYDSVRSALTANEGMQAPATGIPEATVPAILQLIDSDNPPLRYFLGKVGLQRTKQVYAERLIEWEKFNHVAIAAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ85</accession>
    <name>A0A654DZ85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_110085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="IG" evidence="3">
        <location>
            <begin position="299"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="3">
        <location>
            <begin position="892"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="3">
        <location>
            <begin position="1574"/>
            <end position="1652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD15923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2394" mass="258007" checksum="23B4BA96F9C9C0DB" modified="2020-04-22" version="1">MKLLIYILKMTIISIALLSIREAKSQTNTSDSLALVVLYNSTNGPSWTNSNNWLAGSVDTWHGVTVSGGRVVSLDLSDDGTLSYNGNNLTGTIPEDVGNLSELTFLSMAGNALTGTLPTTLGNLTSVQYMYLSTNSLSGSIPPELGNMTSLTALTLFDNQLTGSVPAELADATALDLLYIGDNSLSGALPSALGNLDMIKFDVRNNLLSGTIPSSFSNWINVEEFGLFGNDFEGPIPSGIGASLIFFDISNNAFSELPTITASSATTFNVSNNHFTFEDLEPNESVITLNTGQKAFGNEQFLYTDIGADTLLSPPLPGVGTSDSYYWERDGVVISGATESTLTLTNLQASDGGEYVLYVTNSQFPGLTLNSEPLNLWVGPLGDSCEGAIEATLGTNTTASAPRWFFYSPSVSYEKVLISSLGSGEDTYLRIYSACGGDLLAEHDDIDYPTYPESEAELILYDNDTIWIEWVDQYSSNGFDWTITAGTFSTTNVSDSLALVAFYNATDGTNWFNNSNWLLGPVETWFGVQTASGRVTELQLSGNNLGGSLPDEIGDLDQLQRLNLNINGITGAVPESIGNLINLEVLGLTNPISSLPESLGELNSLWGFNMANSLVTTIPDGLWSLPNLYDVRLVGNAQLEVTLPDTLGKNDALDFFWLDGSSLSGSLPCGADNTSLRVLRIQNMQMAADFPIGITQIPSLQELSLAGNGLTGLIPEELGGLTGLLHLDLGSNQFFGPIPLALTELTSLNYLSLFSNQLSGGIPPELGWMVSLTDLILSHNPLGGTIPPELGNLTNLTFLGLRADELTGTIPPELSALTNLNVFSVRINQLEGDVPSELANLTLLDEIHIESNLFTGLPDLSALSPSVFTVANNFFTFEDLAPNIGTMTSYSPQQLEVPAYDTILAADSELIIYYPIAGVGNTYQWIKNGEPIEGAVADSLVLTNVSGSDNGIYILEARNESVPNLTLTTDPFYVTIEGTGNELTEGPEWSYAYAFGETGARSNTAGMEVDAAENLLVYGSSEGTTDFFGQSIEGTGAFLAKLDANYNILWLTHLAGASAGAGIGDKFVHDKLSGANYVIGQRGLDELVIQDSVITSSVGSYNYFIAKLSASGSFLWIEEFPAQITLDDLTILPDGVLLSGIYPAGSLVVNGETMINQGSEDCFMIKYDADGNRVFVRTVGGSDIEYLCITAADQEGNIYLASEATSQGVTMEDGSQFPMADGDGNVLVVKYDHNGTRIWQDSYSGSSTTDYSSWPTSLTIDPFGNPVLKGWFGKKHGFGTDTLQSPFNYNKFLLQLSPEGTVNWAKGIMEQQYGFGYNEMETDAEGNIYVISDQRGDLYIENAKYPLIGNQDVYIMKYTQDGEVDWIKNATTTTGSSSLGVLAVVEEDNLYLGGSFSDPAFTLDDYTLSSSGISHGYIASIGAASLIPDSITLVAIYDATGGSDWLNNDNWLSGSVDTWYGVEVQNNKVIGLNLTGNQLNGVIPAEIGQLVNLKSVNLANNQLSNVDDSITTLPNLKALDLSGNDLVKLPAGLESMLLDSLAVSHNQLDFGALEALSGVLYEWSYAPQDSVGVRLDTVVSVGEDLILIADGGGTADSYTWKKDGDILVDQVMDSLKLLNLTIGDRGVYAYEVTNLLLPDLTLYGREVQLEVSSLEDDSLALLQIYDALDGANWTRLNNWRSGAPIADWVDVTVKDSRVIAVDLSENNLSGDFPEISSGLVGLDTLDISGNRVISLPDLSGLASLRELDASHNRLGFASLELNQGLSSLLYTPQDSIGIRVDTLGQQGSEYLLTREISGSANSYTWFKESLSDGGITELENTGPTLTINVNGFGDEGAYYAEVTSSIVTDITLVTEPIIFKVSSLERDSTALANMYASMNGASWAGEAANWPNESTIHDWFGVIIENERVTGLELPEKGLTGALGRDILDVAGLVSVDLKDNRITALPDFSALKNLTSLDVTGNHLEFDDLEKNMDVSGIVYDSQRPIGSSAQEIIPQGSDYEVMIAVGGTANSYEWTLTNHLGAHPVEDATGTLQVSGITYETMGEYYLEVTSSLVPNLTLTSGVYQILASADLTFNALDLNGNPFVEGTGYALRVNAPGIPYDTLGIVSGAEAGFVFDDLLLGDYLISVEPEDLEEFLPTYYPGTDLWVEAQVFKLRNDSTEVLKMGQIPPELPPLPEGGVVTGDVGTTLGDEEEGGRVEARRKVKRAGCSLRRFVRSGRIDQDGTFVLIAYVQSDDEGRFTFTDLESGLYRFNVEYPGIPMDPNSFVEFEIGADGMERNTFVLEATITENGIVVKRTNVLGFRRKYFKDLEVYPNPVEDMLTINYRNLVSPNVAARLMDMNGNLIEELTLKNGSEHSVELQMNQLPAGVYLLNFVDRSSNKGHIVSYRIIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ99</accession>
    <name>A0A654DZ99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein OmpA-like peptidoglycan-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="542"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="664" mass="74824" checksum="AC4DCD2FCACEF162" modified="2020-04-22" version="1">MKSRYALLLAFVLTLVIQDAGAQKLKRIKKTINAGLYAKALRMIDAIDQPKEEEHEALQYYRGVSLLQSYRQEEALAALKKSSPSVDEKYPYYLTLAYLQNDSLKAAQSAWGQVDTTLLSQEELELLTIHMNAYESIYLNRKDVVVQNLGPTINSEGHEYNAVITKDQKSVVYTVRRAEMDDMATDGLAYEQILKATLDETGLWENPQQFDRQSSKKHHDATVQLFDHDTKLVTYHDEDLLLSELRDGQWSMPKSLNMLNRLGSAETHCSINETFDTIYYATNFYSANGNLDLYQLTKGADGSWNEPTPLKELNTIYNDDSPYMAANGELYFSSRGHNSTGGYDIFRSRYDRVTGKWSKPENLGHPINSPSDDTYFNVFGKIAYLSSGRTGGYGNMDIYRVFLFNKVRITGQVVDDESDEALPGAEVMVEGPDSTYTATTDEMGRYAMLVPIETVFKLSVTYQSQLVYAQQQVIKVLLQDHNDNVVQLRVNKEGVNGDEVQEQQIAIEMLNDFNVDPERLVPGDMAKPLLATMRVHKPENQEEPIAEIPIPIVHFEFDRSVVTEQYKSTLRLFANEIKDRPSLKLALEGYTDKVGANDYNKLLALKRASAVMDFLVAEGVSSDQLKVNALGEENPLEDTEGESLLNRRVEIKLISSSSAGLVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG3</accession>
    <name>A0A654DZG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025005088" evidence="1">
        <location>
            <begin position="31"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="104"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="37629" checksum="F47970CAE4E401EE" modified="2020-04-22" version="1">MKSNRRNVIKTLGAASTGLALFGGANLVSACGPGKKEQSAEASSEEKAAALFFNISLAQWSLHKSFFGEGLSSWENFGKLWDEHPDKVLQGVLNPVDFPTIAKRDFGINAVEYVNVFYYSKKNDLQFWKDLRKQCDDQGVKSLMIMCDREGNLGDTDEAARTQAVENHYGWVDAAKTLGCHSIRVNAAGNGTAEEVKAAAIDGLGRLTAYGQDNGINVIVENHGGYSSDGQWLSSVIAEVASDYCGTLPDFGNFCVEGGHGNCIREYDRYQGVKELMPFAKGVSAKSHDFDQEGNETHTDYERMMKIVKDAGFTGYVGVEYEGNVLSEADGIKATKKLLEKVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK2</accession>
    <name>A0A654DZK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15263" checksum="FD65F31965CD6C36" modified="2020-04-22" version="1">MSHYIPISRIKPDIQITTARSGGPGGQHVNKVETKVILRFNVLESGHLTEEEKSRLKEKIGSQLTSDGSLIITADSHKSQLKNKELAFKKLDRILTKASFVPKPRKKTKPSKSAINKRIKAKKEHSEKKKWRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM8</accession>
    <name>A0A654DZM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024961489" evidence="2">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15817" checksum="69480BAFB092F039" modified="2020-04-22" version="1">MALIRILIIFLLAVFSANIVNAQSQKDGFSKDMPTENINFGKEANRSSTRPKRQKIEYIYKSSSEGLLYGNPCAMQATRKMGFEYVLQPPGIPGSPTQKESELNNFLVNLKLIFTKSPFWKLILNNRIKKCRQDSGDIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ2</accession>
    <name>A0A654DZQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="232"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="390"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="626" mass="71422" checksum="4C8CE9EE75E6ABCB" modified="2020-04-22" version="1">MSPARKRNLVIYIVGGVLMITLPLFAVWMGSIVRSSAGTGISDELQFFRNALLVASAVAAVLLLVLYWHFQQLLSEYLQEKRKVEEKLETYSARLTSYIESPEYVSIFSLDRDMCYTGFNSLHQKEMRLYFHAHAEEGAYIVDLLPDEIRERTVRNFKRALNGEHFSVTSLYNHRYYTQIFNPVYDDHDNVVGLTSNVFDVTDRIQAEQELENYKDQLEELVRQRTAQLEEQSEFFQKIIDNLPNLIFVRDAQSKYVLVNQAMADSFGLKIEEFIGRTIAETHQNAEDAEKFAAEDVEILANNKTVEEESLHKYPDGSEKWLFLSKRRMQIGAEKYLLGVHNDITNLKQTEFKLLEANHELQQTLNRLRATQMRLIESEKMASLGQLTAGLAHEINNPINYVAGNIGPIRRDLGELKEFLISLNNNHHEQSPVVETQNFELLFDELDSLLEGVNEGADRVKTLMNDLNTFSLPEGAKKVYCDVNDSLKSTINLVRHHLKDRIRLELDFGELPDILCNPQQLSQVFLNILNNAIQAIAHEGVITVKTKRKDGHVVIELSDTGHGIAIEHINKIFDPFFTTKEVGEGTGLGLSISYRIIEEHKGKIEVYSAPGKGARFRIFLPLGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ7</accession>
    <name>A0A654DZQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="107"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1010" mass="117838" checksum="41BF1753E37A1BD0" modified="2020-04-22" version="1">MIRFEESLVRQIEIIKKAANAGKLVLFVGAGVSQNSGIPGWGHLTEELRKDLTGIPPGEYSAQVIAQMYFNKFGKRAYTDKVQRILNTESKQPNPIHNLLFDLNPRHILTTNFDNLIELSAYENQHPFSVVSQDTELPTAEYIQLIIKVHGDFSNGGENIVLKEDDYLSYPRKYPLIKSYIESLFASSVILFIGYGYKDDNLKQIIDQVRVYLGDDSHQAYLIRPEPTDNQIELDYFDKKNIQVISYFDDMWNYLKSGNPHDQPLNIEVNGIEGIGLNLFKILNFISKFDPEVYRLSFENVVNQSLTAIGNLNKQLAFIPPFHLMNIFPFNKGQLKWSYVDDYNYDRSNYSLTTKNSELLSLFAAIKTDKNGHFKGVSSKFIKNILPQKLTPEAEKAFSEKLNSDVSALINALNKNLIYDLPISAAQNTSSGKKRITYKIENQLTDCHSLFFKFQFSKSFEIAYSNNSIKLTAQEYLEHGYTFYQFRDYKRACIEFQNASRIAWKQKLYIIYIIASMNIKRLLKSVDFDRDTTGGDSTKTFIENAINQSGVRHLHETAFSLDVSLTEREIIRYLIEDNMSDSVSNKVRKSLFEVRKLPSTYSDSHLSLTYEINSLFVHLNANCIIYDHYTNFKNLVRDAFESYCLNYSKSNPKTQFEIFYLEIAILYISYLDVSDILSDSLIERINIDENNISGFIQIINDLLESSYITNEFGKVSSNNFNDDKVMFGFKDRLSQMINTSLALMAKIDIDSSHFELLTNPILHVIQLMRRHELKHVSGVLLKHQEAFSNIQLETILLNLLDHDIWAYNSIYSVINILKERDENYKIKRADILDKIRSLDFKGEQGLPFRLYEITDIEIKHFIKEVIENRMKETFHEDDYKSAVISDIVEPSLYLSPYLQRILGNTDKRETIINHWHYRFIIEHLIERLHLENLFQNELNELLENSDYFSWLYKPEAFNYERFDKEWLNFERSDWFISRIKNVDILKEKVQEIAETDQDKELAYFFTCHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ8</accession>
    <name>A0A654DZQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="50" mass="5650" checksum="80BE5E5A199055A0" modified="2020-04-22" version="1">MPTRVRLSCFIQVHMKSPLGKMIIQVPNNLLRLFAGLDVGNKDVYHMLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX8</accession>
    <name>A0A654DZX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0114 protein MARINOS108_120256</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UPF0114 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00143">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005134">
        <property type="entry name" value="UPF0114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020761">
        <property type="entry name" value="UPF0114_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38596">
        <property type="entry name" value="PTHR38596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03350">
        <property type="entry name" value="UPF0114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00645">
        <property type="entry name" value="HI0507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="21711" checksum="D1F60A40550FD089" modified="2020-04-22" version="1">MAQDSGIKRFENFFEGFMFWSRWVQAPLYTGLTIGAFLYLVKFFQELYHTFQQTTSLHETEMMLRILGLVDISMVMNLVVMVTIGGYSIFTSRIDVDSHEDKPLWLEDLDAGQLKIKLATSLASISGVQLLKTFIDYREAEQKAGAEGIIIEIVIHMVFIISALLLAQTEKITHSYKHGHAAAVKFSDEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E017</accession>
    <name>A0A654E017_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="27774" checksum="99AD213D9D53222C" modified="2020-04-22" version="1">MAYSTETESFHYNQLQVQQLQNLYVADRNRFLEVIDFFPLMVSSNDVDGWSFRMVNQSFAEYFERDKQFLLEVDNAYSTKLVHPESLAYISQFLKNHPYESSKSQVITYYQNVRKSRDREYAWFLTYKKFLDKDHYFSLYHTLTELGRTGRILRDFLGEVPVSITNYLRYQSLTNREKEVLKHVARGTTNQEIAEKLVISKDTIRTHRNSIWKKLGIKRVQDCLIYDMFFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E4</accession>
    <name>A0A654E0E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3857 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3857" evidence="1">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="614" mass="70808" checksum="631838C5F86B0127" modified="2020-04-22" version="1">MTTPTRTPLFLISFFLFQYALAQVGSGILEYNIDLEVNKGSLVETKSYLIKIGDREANWLGDISIHHQATDKFKLIEAVLLDQSFNVVRKVKAKDVYTKNMNLTSTFFDDHLEDKFSLKHNQFPYYIKYSYRVIKRDFLFLAYWIPQYYSNVSTISSSLSLTRPLDYEIHLDSIGEFTYSSTEAEGLITEKWSIKHPKKIGKEDFSPPATESLQQISIVPSDINYGVKGSQASWEDFGEWVANLNSELDVLPEEEITILRKKFGHLENQDTLIKELYHYLQDNTRYINVSLDIGGMKPYPAEYVLINKYGDCKALTIYMKALLNAFHIPSFYTLVESGLNPKAIRENFPSQQFDHVILCVPTKSDTIWLENTASYLPYNYLGSFTQNRKTLLINKGGSQLVRTPALTHTDVHQTNNYHLTFDEDRLTGTLHSKLRGEDYEKIAYVETNLSSQEKRKYYNKYFNNQGFELIDLTIHQNNRSLPEVELNAQIDLPKHLRQVGPLRIISLPASPMPASEVFKNRTRPVRLMMPIDAHDKVIIDSSQNWTWKLPKDFSLISEFGTYQITYELVNNSPVINRHISLRSGDIPIENTGELYTFLLEIETYESSAPIIPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q3</accession>
    <name>A0A654E0Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="29549" checksum="BA0AE28205349E02" modified="2020-04-22" version="1">MLDQERTYYNLGVSSLEDVTKKNYFSLFPEEVVASFLDAFIINLPMSGKVGGDGFWIFKDGEDLFIALFDCMGHGHLASMMTRVYKQSLQRVMESYETRDPGTILRYLHHKIATKFSDREKLQVGTGADVGLLKINLAIRHVEFAGAKVDLMHVKKGKMEIIKADRMQIGEMFEMQHTYQTSTIVLEEGVKSNLYLSSDGFRDLMGGDKNKKLGRKMVAEAILENADKPILDQKTLLTTFIDQWKGSNDQPDDVLIMGFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S2</accession>
    <name>A0A654E0S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_130002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="436" mass="46859" checksum="3683DC1FC20221FC" modified="2020-04-22" version="1">MKQFFLYTLLLCFIWSCTPSDENSPAPTEVFVKYYGQGTNEAVDLARTSTGEIIILGSNIQSESQDFYLLKVDAEGNEVASEVYDLKSGSTDIPLKMKPLGFNSTTGLDEFLLVGYIQSRDASGLDFFEGAWCKIDADLNIISTGSDSSRFNLLENVITTDIIRTTETDGVEKFVVLGHSRQTFAGDPVSDGGYQIYLTKVDDQGEVYWSKSHGYLGDEESLALFENADRSLVIVGSTEAGADGRNVYVIETNSLGTSDKNAPRIVINNSVSGADETPTAAIKSSLGYSIVGYTTGVNGQMAGFHVAITPSGDMVANSNNVLETDYSLPCQALALTKTIYNDLMVLGSIPNFRETTGEGTAGANKLEQILLMRVSPLSGHIEGFDQNYGTTVGNDQARAAITLPDGDILVAATIDFGSGTSMLGLLRLNRNGELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W1</accession>
    <name>A0A654E0W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13965" checksum="7B4BF0695C5A8691" modified="2020-04-22" version="1">MKDGIQLFFLSLSPTMKRFYEKVPRIFKNFYFLSALFFLIWMLFFDSNDIITQIKLGHKQAELENAKEFYEHKIVEVKNDREALLNNKELLEKLAREKYLMKKESEDLYIIVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z7</accession>
    <name>A0A654E0Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="14"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="373" mass="41312" checksum="D970E4D89A06C52D" modified="2020-04-22" version="1">MVSFWEQQSLLSYDVIVIGAGITGLSTAASLKEKSPNLNILVIERGSLPTGASTKNAGFACFGSISELVQDRKALGDEGMTRLVKRRWDGLQKTIQRLGRDQIGFLQKGGYELLTEVNSHYLDDMESLNELLRPVFDQPVFSQTDEAIGTFGFAGTKHLIFNQYEGQLHTGKLIRSLWQYCAQSGIQIITGTEVTALYSQGEQVTVQTKNYAFRAGAVAVCTNAFTKELIQTPLDLTPGRGMVMVISPQRPSTISGTFHYDEGYYYFRDFEDKIIFGGGRNLAFEEETTTEFGFNEKIEQKLHQILKEIILPGNAYTVDLKWSGIMAFGQTKEPILQKVQPGIYLGVRLGGMGVALGSLLGEELAERIVRDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E107</accession>
    <name>A0A654E107_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">frr</name>
        <name evidence="5" type="ORF">MARINOS108_120517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="20965" checksum="1A2EEECAB61F4E20" modified="2020-04-22" version="1">MEEIDFYLDHSQEMMDKAVSHCNSELAKIRAGKAMPNMLDGITVEYYGASTPLQQVASVTTPDARTLSIKPWEKKMIPEIEKAIINSNLGFNPQNDGELIRINIPPLTEERRISLVKQAKSETENGKISVRNVRKEVMDSLKKLLKDGASEDAIKGAEEEVQKITDLHTKKLDDLLELKEKDIMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E111</accession>
    <name>A0A654E111_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="60" mass="6768" checksum="24AB15EA66F698A5" modified="2020-04-22" version="1">MKALFSTIANTTVAYYDFCMKLSNLLLSNQQTDGNLRKNTIHRGVHFGCSFSSLDDPRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E154</accession>
    <name>A0A654E154_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22671" checksum="A5AC561C3F87AA67" modified="2020-04-22" version="1">MLPLSTLENDVIRLSPLESGDWKKLTHLVSDSSLWTYFPYDLAEESVFESWMESRITLMNEGKWLPHVVYHKPSGKYAGLTCYLSIDEPNKVIEVGGTWYGSEFHATEVNPNCKLLMMTHAFETLGFYRVEYKTDVLNVRSRRAIEKLGAKEDGILRSNRIVAKGRRRDTIYYSILKDEWPQVKANLEKRIATYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E176</accession>
    <name>A0A654E176_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15139" checksum="D11CF60B16C0455C" modified="2020-04-22" version="1">MNELKINHLAVLVSVIWMFVLGFLWYGPLFGESWMSMVGLTMEDAQANPPGAGVWITNVISSVVPVYLMAWFFVKMDVRSLVAGAIHGFLIGFAFNLLPGMSGGMFSGDPYALAWLEGGFQVVGWAVSGMILGAWTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H8</accession>
    <name>A0A654E1H8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoglucanase</fullName>
            <ecNumber evidence="7">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018221">
        <property type="entry name" value="Glyco_hydro_9_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00592">
        <property type="entry name" value="GH9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3 5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031598352" description="Endoglucanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="CelD_N" evidence="8">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="9">
        <location>
            <begin position="595"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="664" mass="73099" checksum="10A806B393BFFEB0" modified="2020-04-22" version="1">MKKILVPLLLLYFLESLAQTAPGNIRLNQVGFLPEAQKIAVVVGSSQSAFEVIKNSNSAVVFSGTLSASKYWSKSEEDVKIANFSDFKTRGTYRLKLGNGDLSHPFKIADDVLLDVTSATIKAYYYNRASMELTEEFAGVYNRPLGHPDNAVVVLPSAASDERPAGTVISTPKGWYDAGDYNKYIVNSGISTFTLLAAYENYPEFYDTLDLNIPESGNALPDLLDEALWNIEWMSTMQDPNDGGVYNKTTTANFQGVVMPHKATATRYVVAKGTAAALDFAAVMAMAYRIYKPYLPDFADECLAKAELAWTWAKTNPNVSYNNPGAQDGYPAVHTGGYGDGNFSDEFFWAAAELYISTKDDSYFSTLNFSQYFGIPGWPNVQTLGILSLITHRKSLTAAADTTAIKNILINMTDDIKDYQKNTSPYLIPNNDFYWGSNSIPGNQGMLLMYAYELTNDVDYLNAAIGAVDYLLGRNATKYCFVTGFGTVSPIDIHHRQSGADNVASPVPGFLAGGPNPQNVNDDCGASKYPSLVAAQCYVDDFCSYSTNEITINWNAPLVYTAGAIHAVYDRDFKTPNTDPVEEPLSLSPSFKVEIYPNPADDFLIVQTDEHTFGEMDIRIFSINGKEVISTTQSRIDVSALTQGVYVVRCKTRQQTISRQILIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J6</accession>
    <name>A0A654E1J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="224" mass="26399" checksum="ECFAC6009629F71B" modified="2020-04-22" version="1">MVVLQLVLNKNLYSKDPQSSELGQRITEHSIEMIHQLGFEGFTFKKLSDRIDCTEASVYRYFENKHRLLVYLITWYWAWLDYRIEYETHNLEDPKTKLSRALRIITEKKMKDPAFPDINEEALHKIVIAESHKIYLAKQVDEDNKDGFFRGYKSLCKKIAEFITEINPSYPYPSTIVSTAMMVANQQIFFAEHLPSLTELSKEDDPYMANYEFLKSMIFQTIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M1</accession>
    <name>A0A654E1M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK family alpha-L-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025839">
        <property type="entry name" value="RLAN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14401">
        <property type="entry name" value="RLAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="287"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="482" mass="55370" checksum="7A15A7EE0CF360C6" modified="2020-04-22" version="1">MAYKLIVTERQDEWKDLPDDVELISPSDYFSTDIYQKSRKYKVVNLCKSYQYQSVGYYVSLLAEARGHKVMPQITTLQDFRFPALVREDAEDFDDIIQQSLKKQTGDKLDLIICLGQVYQPQFARISTLLFNLFQVPILKACFTKKDKWMLTQLKPLNLSELPEDQKGLLRTALDEYLQGKNKLNKQYSRKKYDLAILINPEEETPPSNKKAIQNFVKAGEKVGFNVDLITKNDFAKLIQYDALFIRETTNVNHHTFKFAKKAASEGLVVMDDPESILRCTNKVYLSELLRAHSIPTPAYYIIKKDKMSQINASAFEYPIILKQPDGSFSKGVKKAKNEAELIKVLKDFFQTSELVIGQEFIPTDFDWRVGVLNKKPLYVCRYYMAADHWQIVNWKGSDTPDEGDADTIAVEDAPKALIDLAVKATSLIGNGLYGVDIKQRGKKFYIIEINDNPNLDEGVEDAVLKHQLYQTIMQEFMNRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U9</accession>
    <name>A0A654E1U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="9944" checksum="54A2AAC4D64A9D68" modified="2020-04-22" version="1">MTWLSEGPKKKALQRFNAFKTATKTFEHSLFWSHEIIPKDEVRLHFYDFNCSIPQISSLVIPELRTIVIGPCDGTATQVGHAGGEGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z7</accession>
    <name>A0A654E1Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gliding motility lipoprotein GldD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gldD</name>
        <name evidence="1" type="ORF">MARINOS108_20272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019850">
        <property type="entry name" value="Motility-assoc_lipoprot_GldD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03512">
        <property type="entry name" value="GldD_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="22398" checksum="AC5AD04DED406314" modified="2020-04-22" version="1">MTIRISILFLISILVLSCGQNPYLPKPKGYNRIDLPAHEYTALADSFPYQFEYSKHARILKDSSWITERYWIDIFYPAMDANIQLTYKPIKNKAELMQEYFSDSYKLTSQHNVKAYAIDEKVLELPNGDFASFTELEGEVPTQLQFHVSDSTAHFLRGALYFKTATKNDSLAPVIRYLKEDALHLLETLEWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E269</accession>
    <name>A0A654E269_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024951812" evidence="1">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="27421" checksum="B2423FC1D3C2B6A5" modified="2020-04-22" version="1">MKPILLLLLSVMFWSCLESTLDTTDKITDNAINYLGPNHDVGDVPNDSYRIIGITPSQNTWKVIVEYSGGCNEHLFYTWWNGNTTGDNVSVYLFHNSNGDNCEAVVRDTINIDIHAALINSVALEETSVSVINAKSLKRIRVDPYLALLPQGTECLQVVSLLGTSCGDGIWDNQWMLLADTFLTHQKVWFQPVKNSTNVEIRKPEAGSYSIAITLLFGFKYDSSSDATCQSLPEGAIVPVAINCLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D2</accession>
    <name>A0A654E2D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purU</name>
        <name evidence="5" type="ORF">MARINOS108_20081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="33341" checksum="B742AE6FA6CE9258" modified="2020-04-22" version="1">MGLKNHAILLIHCTDRKGLISTITNFLFEHNGNIIDLDEHVEKTEGVFFMRAEWELDGFTIPKEDIHGTFQDKIASQYDMDWQLHFTDKKPRMAVFVSKSSHCLYDILSRHYSGEWEIEIPAIISNHTVHQTIAERYDIPFYHFEINKDNKQEMEQAQRSLLSELNIDFLILARYMQILSDEFINAYPNKIINIHHSFLPAFAGAKPYHRAHERGVKLIGATSHYVTADLDAGPILEQDVVKISHKNSVEDLIRKGKDLEKIVLSRAIWTHLQRKALVHNNRTVIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G1</accession>
    <name>A0A654E2G1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MARINOS108_20111</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 12"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="756"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD18191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="797" mass="90511" checksum="668BD473A6AC0A74" modified="2020-04-22" version="1">MLVIKRDGRRESVKFDKITARIEKLCDGLNSDFVKPVEIAKKVIDGLYDGVTTIELDNLAAEIAATMTTRHPDFAKLAARISISNLHKVTEESFSNTMKRLYTYVNPKTDENAALVSTEVYGIIRANAKRLDEAVDYTRDYNYDFFGYKTLERSYLIKLDGKIVERPQHMLMRVSVGIHMDDIDAAIETYNLMSEKWFTHATPTLFNAGTPKPQLSSCFLLTMQDDSIDGIYDTLKQCAKISQSAGGIGLSIHNVRATGAYIKGTNGTSNGIVPMLRNFDMTARYVDQGGGKRKGSFAIYLEPWHADIFDFLELKKNHGKEELRARDLFYALWIPDLFMKRVEENGEWSLFSPDEAPNLYESYGDEFEKLYEKYEKEGRARRTIKAQELWFEILESQIETGTPYILYKDAANKKSNQKNLGTIRSSNLCTEIMEYTSKDEVAVCNLASIALNKFVNEKGEFDHQKLYEITKVATRNLNKVIDVNYYPVPEAKTSNMRHRPIGIGVQGLADAFMLMKLPFDSPESRKLNKEIFETIYYAAMETSMELAQKEGPYETFKGSPVSKGIFQFDMWGITPDSGRWDWYDLKQKVRKHGVRNSLLLAPMPTASTSQILGNNECFEPYTSNIYTRRTLSGEFIVVNKHLMTDLINLGLWDDRMKNRIMTANGSVQGIPEIPEDIRERYKTVWEISQKSIIDMSADRGAFICQSQSLNIHLLDANFGKMTSMHFYAWKKGLKTGMYYLRTKAATDAIKFTLEKEGAAQPEGKSKPAADPDADKTQNQAAMQCSLDDPEGCEMCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G2</accession>
    <name>A0A654E2G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alginate lyase (Modular protein)</fullName>
            <ecNumber evidence="4">4.2.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.2.3" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045135">
        <property type="term" value="F:poly(beta-D-mannuronate) lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alginate_lyase2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_lyase2" evidence="1">
        <location>
            <begin position="422"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="3">
        <location>
            <begin position="714"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="804"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="885" mass="95528" checksum="E79A0744FD60CC9F" modified="2020-04-22" version="1">MKATTTRESEFSSSKGNICSYLIMFVLLQFASVSASWAQDPDLPPSGNFDLTDWKITLEDQSEVQEADLSNGFERPAQFYTDPNTGAMVFRCRNDGETGGSSYPRSELREMLRAGNTSFNTQGIGPNNWVFASSSQANQEAAGGVGGTLTATVAVDHVSTTGEAGKVGRVIIGQIHASNDEPCRIYYRKLPGNTKGAIYFAHEPTTSAEQWHEMIGSRSDNAPDPEDGIALGEKFSYEIKVEGNDLTVTIMRPGKPDVQKVVDMTDSGFADDWMYFKAGVYNQNNSGEDGDYCQASFFALSNAHSTASNKAPTSSITAPSSGATFSAGENITISADASDSDGSIAKVEFFHGSTKLGEVTSPPYDYTWSDVPAGRYVITATATDDGGISYTALGVSIAVNPVAEYNAPYDIPRFKAFIGECKLQAPTSSTIATQTQLKDGYTDDNFYVVDEDKVAFNQSGSSQRTELRYLNNWTLSEGDRSLHARIHIVEMTCDQVTVLQIHDDANTGSGPNKPLLRIYKHQTKEPVNHLWAAIKTDNEGVNTTHVDLGEAPAGYFDCDVRLVDGSMIIDVDGAEKANMDVSYWTFPSYWKAGVYLQDDGEATAYFDELYVADGSGGNVNPVVSIISPENGASFVNGDDITIVVDASDPDGTLSKVEFYNGATKLGEDSTTPYSFTIPFAVTGSYIFTAVATDNEGATTTSSEINVAVTATQTYKLTTSAVGNGFVSYNPSGGVYEVGTLVYLTAKPDDGNLFDHWSGDVTGTSAQTTIIMDADKSVTAHFSEEEVTLSVDPNTLEASNRGMIVYPNPIHSKATIEYKVKKPALVELTIFNVSGQKIVNLVNELQNAGTQKVEWTPDNLPNGLYIAKLRIGNETKTQRLIIQPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H2</accession>
    <name>A0A654E2H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional repressor for pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="27322" checksum="5FCD18982E016C97" modified="2020-04-22" version="1">MEILSNFSRIKIETPVDKIINQIKELITSGQLKPGDRLPPERKLCEKLGVGRTHLRDAIKKLEFYGILKTLPQSGTVVGGMGITALEGLISDVLKLEANDFRALVETRVLLEVNSAKFAAMRRSDADLIHMSKALSDYEKAVSKGADTVEHDLMFHLKIAEASNNTALKSLMLIISPDILTHFKENNICGGDRPVCALEEHYQIFEHIESRNPELASETMEHHLQDILSFSLEQSGFINGKTKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N7</accession>
    <name>A0A654E2N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cbs domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="25010" checksum="53385C8D2AC22C71" modified="2020-04-22" version="1">MIAKDLINYMIPPLKPQDEISKAKQWMDELRLSELPVVEGGLFLGLIDEELLLNDELRYPAVGDYPLVGQQCMVHAGNHYYDVLKTSGLEGFRIVAVIDELNQYLGVVSIEDVVEAFAQNSSVNTPGAILGLRLKLHDYSLAEISRIIESNEAKILSSYLSPHSIEPGELNLTLKINKEEITHIVASLEQHGFFVENSYNMRDSSYEEKERIDILMKYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R0</accession>
    <name>A0A654E2R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="19615" checksum="590FCE55D0FF078A" modified="2020-04-22" version="1">MIRVNIQQQVLHFIVFLVIQIPFLYKLILFNSAFGFFYIGFILFLPYALNRSLTMVIAFLTGLIIDAFSNTPGIHASACILVAFVKDGWFNLMMGTSDDDVYLDWNELKVWGSIKYLLPLIFIHHIIIFTVENGGFNSFGFLFSKILYSALYSFIIVFGLSFLMAPKARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R7</accession>
    <name>A0A654E2R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815650" evidence="1">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="18222" checksum="D7AE5D38275EB4C4" modified="2020-04-22" version="1">MKKLSLTIFALLLIALTYQAEAQSKVVAKDLIGSWKLVIDVDEEFEEAKREVDEEDSFLGKIILNSVSGIVSGILEEIDIYMEFKPGGEVKVIVEAFDEREIEYSEWQIDKKGRLYISDTENFSTGDSDYWLMEKGVLILFEDDNERSDNVYLVNMDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S1</accession>
    <name>A0A654E2S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rffG</name>
        <name evidence="7" type="ORF">MARINOS108_20552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="39394" checksum="564C507DDCCD05EE" modified="2020-04-22" version="1">MKKVLITGGAGFIGSHVVRLFVKKYPEYHVFNLDKLTYAGNLENLRDVEAAPNYTFIKGDICDASLLEELFEKNDFDGVIHLAAESHVDRSISNPMAFVETNVLGTVTLLNAAKANWKGKPGKRFYHVSTDEVYGSLGAEGYFTEATPYDPKSPYSASKAASDHFVRAYHNTYQLPVIISNCSNNYGSFHFPEKLIPLTIHNIQQGKSIPVYGKGENIRDWLFVEDHAIAIDVIYHKGKTGETYNIGGFNEWTNIDLVRLLCKIMDRKLGHVPGTSDRLITFVTDRAGHDLRYAIDASKLKNELGWEPSLQFEEGLEKTVDWYLENQDWLSDVTSGEYQNYYNAHYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V5</accession>
    <name>A0A654E2V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="367" mass="40087" checksum="69FF2D6FA6E95628" modified="2020-04-22" version="1">MSIIISIIAAFIVTFILLPIIIKVSRSVDLLDAPDRRKIHRVSTPALGGIGIFVGFMVAVFMAVPLAELATLKFFLFGLIIIFFMGIRDDISSLMAKHKLLAQVFAAFLVVYFSDIRLTGFYGMFGIGEMPEWFSIPFTIFVLVGLTNSFNLIDGIDGLAGTIGILILSFFGWVFLTGGYYAYSVLCLSVVGSLFAFLLYNWNPSRVFMGDTGSMILGFIISSLAILFINVAPGMTLGYFEITSSVSVCIAALILPIFDTVRVFTIRFSNGKNPLDPDRNHLHHGLLKLGLNHAQATIFLGLFNLLILSMALLLDPYLGNGSLMLIITAMCVGVTMTLGYKLKRKGHLGKITPVATKSSDLYISKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z2</accession>
    <name>A0A654E2Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbG</name>
        <name evidence="2" type="ORF">MARINOS108_20565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.45" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047733">
        <property type="term" value="F:CDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05252">
        <property type="entry name" value="CDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="41722" checksum="27647C34D654865C" modified="2020-04-22" version="1">MTSFGVENYFREKYAGKRVFITGHTGFKGSWLTTWLIEIGAIVKGYSLEPVHGLNLFESLEIKGNHESKIGDIRDYERLESEVVDFEPDYVFHLAAQPLVRYSYDYPIDTYQTNVIGTGNLLMAIKKLDNPCAIVLITTDKVYLNNEWHYPYRETDRLGGYDPYSSSKACCELLIDSFRNSYFNLNQYQYHQKAIAVARAGNVIGGGDWSRDRIIPDIVKALRSNKTVEMRNPRAVRPWQHVIEPLAGYLLLGARLSETPCQFAKAWNFGPLLQDNITVNKLVDHAIEIWGSGTSKDISNDKDPHEAGLLKLDINKTLNELGWKPKFDSKEAIHLTIQWYKDFISGQNSKDLLLKDISKYLKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E308</accession>
    <name>A0A654E308_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="35787" checksum="CDB6C7A0D15E04A2" modified="2020-04-22" version="1">MTQTMKATVATGYGLPDVLRLQVVQKPIPKPDEVLVRVMTAAATTADAMMRTGKPYIARLFVGITKPKKAIPGTGFAGVVEQVGQGVTAFKMGDRVFGETTFGFSSNAEYLTISQNGVILAMPENLDFSEAANFCDGHLTSYNFLKEIAKVKPEQKVLINGASGALGTSAIQIARYMGAHVTAVCSGRNVGLVRSLGADEVIDYLQKDFTKSDRKYDYVYDTIGKSSFSACKNILSEKGIYLSPVLKFSLLLQMIKTSLFGQKKAKFEATGANKEEKLRCLLSEVLDIYKEGRLKTVIDRQFPLEKVAEAHHYIESGRKKGNVVIVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E351</accession>
    <name>A0A654E351_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="27357" checksum="7AEF510EAF987F58" modified="2020-04-22" version="1">MKIAFFSDIHANLPALDAFFKDIEQVRPDALYCLGDLVGYNVWANEVVEAIRKRHIPTIMGNHEEALLLPLKEDDRSAKGITARLLTTENKDYLTNLPRHLKLVFETNGEPFTLLLVHGSPKAVNDYLVEDYPEDEIVEMMKAQNAQFVLCGHTHIPYHRTIQTGMDYTHLVNIGSVGKPKDGDPRLCYALITLYENLSKHNPNAIRVEFRRVNYDIDAAVSAIKESEFPNELADQLLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E374</accession>
    <name>A0A654E374_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate dehydrogenase/leucine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="2">
        <location>
            <begin position="181"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="45363" checksum="276EDCE65F1E58D0" modified="2020-04-22" version="1">MKDLLKKFENKKPEIVFEWSDPETEAEGWAVINSLRGGAAGGGTRMRVGLDKREVESLAKTMEIKFTVSGPQIGGAKSGINFDPNDPRKNEVLKRWYKAVYPLLKNYYGTGGDLNVDEIHEVIPITEGFGLWHPQEGVVNGHFNPPKPQKIHMIGRLRQGVSKILEDQNYIPTSDKKYTVSDMITGFGVAESVRHYYQLWGGDITQKKAIIQGWGNVGATAALYLSYYGAKIVGIIDRDGGIINENGLGLEEIKKLFYDRQGNKLIAEDQLSFAECNEKIWNIGGEIFIPAAASRLVTQDQVEGLISHGLEVVACGANVPFKDDAIFYGPIAEYVDERAALITDFISNCGMARTFAYLMDPKNDKKITDDEIFTDISKTIATALDKVYQQNPGKTGLGRAAFEIALSQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G5</accession>
    <name>A0A654E3G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="311" mass="35176" checksum="8D1A0AEE5324E12E" modified="2020-04-22" version="1">MQNILKNTDEGDSTPWMLLLILGGYVLAALFLFSFIAQGLIMLLFNYDVQESLGILTNPYGSESAKLPLMIIQAVTSIGAFIVVPLFFIKVNLKGRYAPFFNFPEQALRPILMTVVILFCFMVANSVVIEWNQNVDMPDIFSWFENWAQSKEAQLEKLTEYLTTFSGIHEYLIALVVIALIPAVGEELLFRGLIQNLFGKAFNNPHVAIWLSAIIFGIFHFQFYGVVPRIFLGALFGYLYYWSGYLSLAMVGHFINNGLTLTLLYFSQIKFINYNPAEADSSPPLYVVGIFFLAGAVLLYLFRNLFPEKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V9</accession>
    <name>A0A654E3V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="3">
        <location>
            <begin position="735"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="833"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113705" checksum="E2641728340624BD" modified="2020-04-22" version="1">MKQIVQKCILVFCFLNQPAYSQDKKLIFNHISLDEGLPNVPINCITQDSYGYIWLGTTEGLFMYNGYHFTRYTYNDSTSISGNYINAIIEDADKDILIGTNGRGFCIYNRESEQFEGFSHRDDVPGSIINNTVKSIFQDSKGNIWIGTLGGGVDIFDKEKKIFRHLTTPGSTYSERHVSSFAEDNSGKIWVGHYEGDLCYYPSAQSELVCMTDSLEEKVNIDGYLKYLYVDSNNELWIGSISSGLYRYNIDTKQVRHYIQGDATGDLTSNIVTAIQELSPGILAIGTDGGGLELLHTDSETFEHYQHNPGNKNGISSNAIHSVYIDNDKNLWLGTFREGLNLASKNIEKFVAHSVRTDANDGLSQKSVLALLEVDNETLLIGTDGGGLNIYNRPHQSFLHLKHSQDNKKSIGGNVVKALFKDSKGYIWVGTYGNGIDRYDLQSNSFEHNAEIPGIPEDIKDANIWNITEDHNQNIWMGTLGGGLFRYNLNTKQFRRYIHDPEDPASISHFQVMCTLVDHQGRVWIGTEDAGLDRYDPQCDCFEHFSNRPDDPGSIPSNFIRTLFEDSKGQLCIGTEGNGLVILKNNGTFARYDGVSGFASNTVYSVLEDDQYQLWLGTTKGLTKLNTVNGTIKNYSTNNNLQGDLFNMSSCLRTSDGTLFFGGINGFNEIHPTQFELNNTEPHLEITNLRILNKSVKVGEKINDRIVLKKSLALTSELDLTFKDKTVSLEFAAIDYTNPRMIRYKYMLEGFDDEWNLVNSEKRFATYTNLPSGEYQFMLLAAGPDGIWSDNVRTLTIRVAPPFWNTLWFRCLIFIALAIMVTAWYRTRVIKRERILKQERLAAEKEIIKLQNENLEATLVNQNSKLTTSILHIAHKNKVLRNIKEELENVTNTNSTPVKNQYLRLVRSVDREIADDENWQQFEIHFNETHHQFIQRLHEKHAGLTKSHLQMCLFIRLNIQTKEIANILNISVRGVEKSRYRLRKKLGLSSSESITDYLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E499</accession>
    <name>A0A654E499_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_50053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815347" evidence="4">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="37704" checksum="8FC59936732F91F9" modified="2020-04-22" version="1">MLNPRFLFLLILIALSACIETQSSKGQEDTPNAAPQVPTNPSGRMVSLLGTVLPPKQLSERVMGKRLEQLEDARKKYESDPENLDNIIWYGRRMAYLGRYQEAIRIYSIGLDINPNSYRLLRHRGHRYITVRKFDAAIEDLQRAAFYARPAENKIEPDGLPNRLNKPLSNDKFNIWYHLGIAYYLKGNYDKAISSFKKCITYADNDDLIVATTDWFYMTYRKIGNLPAAQELLAPISRRMNIVENYAYHQRLMMYQGHYQPEDLLDKADRDNDSIDPTIGYGVANWYLYNGQVDIATELIDKILRNPQWDGFGYIASEVDKVSLGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P5</accession>
    <name>A0A654E4P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="23071" checksum="191071E12044F3BA" modified="2020-04-22" version="1">MKSRELYIAYSVRRDHDLWQDLCAGDRNALDYIYYSQVPALLSYGRYLTPDSTLVDDCIQDLFVDLWVKRDRLGPVRTIRFYLMKSLKHRIVRELQNQKKRRSLTESEGAFEELEDPNPFFSAGQYQPTSAVVECLNKLSPLQKEIVYLKYFNGLSFDEIGDILELDKKQLYNALSKAMHNLRGMLKLAVLMILLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R1</accession>
    <name>A0A654E4R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">MARINOS108_120482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="19878" checksum="3C21D8318F63400A" modified="2020-04-22" version="1">MSRIGKAPISIPAGISITVDKTVVTVKGPKGELKQEIHPDMKVNIEGDTLTVERPTEQKRHKAMHGLYRSLINNMVVGVSEGYKRELELVGVGYKAAVQDNILELNLGYSHNIFLAVPGEINVGAETAKGQNPKVTVEGIDKQLVGQVAAKIKSLRKVEPYKGKGIRFVGEIVRRKAGKTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T3</accession>
    <name>A0A654E4T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="19566" checksum="9550D3BAB68ED632" modified="2020-04-22" version="1">MDFKNLKTKNLEKGTLLLSPGQKCNYGYRVISGCLKSYVLDSSGKDHILQFAPEGWFISDLESFTKQTPSKIFIDAIENSEVQMIGKEVVPSFEELNHEWQVELGLKFRNNLIASNNRLISLLSGTAEEKYLEFTQTYPALVQRLPQKLIASYLGMTPEHLSYTRGKLAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W0</accession>
    <name>A0A654E4W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glucosamine-6-phosphate deaminase-like protein BT_0258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="44"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="654" mass="74580" checksum="CA41970AC207EDA9" modified="2020-04-22" version="1">MTDILEEPIQNSQILTHEMVGLHEEKRFEKIHNVVFSESSIGSRSIAMEIADLIRHKQSKGDVCVLGLATGSSPKGVYNELVKMHQEEGLSFHNVVTFNLDEYFPIAPISSHSYWHFMHEYLFDHIDIDPENINIPKGDLQESEVRKYCLEYERKIETYGGIDLQILGIGRTGHIGFNEPGSHVNSITRLVTLDQVTREDAAGDFYGKENVPRKAITMGIGTILKAKRILLMAWGESKATVAGRMIEGDISGEIPATFLQQHHNTTVVLDTGSCAYLKRIYTPWLVGGCKWDEFTTKRAVVWLCQQTGKPILKLTERDYNDHGMNDLITAYPSTYELNIKMFNALQHTITGWPGGKPNADDSQRPERALPAQKRVVLFSPHPDDDVISMGGTFIRLHDQGHEVHVAYQTSGNIAVFDEEVIRFADFYNELKNSQDNKQSGQKEFYQKIKADILNKGTGEMDTDDVRRIKGLIRRGEARAGCRFVGLPDERAHFLDLPFYETGRVKKLPISEEDVRITVDLLRAIQPHQIYAAGDLSDPHGTHRVCLDVIFKALEVLKDDDWLKDCYVWLYRGAWQEWGIEDIDMAVPLSPDELMKKRQAIFKHQSQKDGVVFQGTDGREFWQRAEDRNRSTAKLYDQLGLAEYEAIEAFKRYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z1</accession>
    <name>A0A654E4Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024819349" evidence="2">
        <location>
            <begin position="27"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="39993" checksum="0F9AFDBD03C3EDE4" modified="2020-04-22" version="1">MKEQMNMVIKGAVLSLFLLLFAGASAQMTIHVINVGQGNCVFVEGPKVDGKRRTLIFDGGKSERSYEIVDYLTRLGYMPDKTVIDYMVVSHKDADHFEGFMGLLSAGYDIDTFYHSGSDKVQKDYDTEFIPQVKKLARKLYVMKPGYSINMGNGALITCMVSGGQLIGGEVIEDLSENDKSIGLLFEYGDFEFFSAGDLGGGKFAADEKCTNRSTSQKNIESSLLRAMQRERFIERDKGIEVLHVSHHGSESSTNYEFMNGMSPTVAVISVGQNQSTTYQHPRIDIVERVLMAQAPCITVPPALVLQTEEGLDKGKTSFEGLVVGDIIIEVDASGDYKISTTGEFEGTSTDSVPPGLWGEFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E520</accession>
    <name>A0A654E520_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="5837" checksum="A1B0FF70A33021A3" modified="2020-04-22" version="1">MNTFEVIFLIDQNGLGDSQKGIREWGGAAINGQMRPGLRLGCGFNKKRSVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E590</accession>
    <name>A0A654E590_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper type II ascorbate-dependent monooxygenase, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="SSF49742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="452" mass="51514" checksum="8673C99045FD9C4A" modified="2020-04-22" version="1">MRAQAYLTLLILLLASCSEKENKPEDPLKAYTSSYEIIQGEIWDQTCISCHVSGSSFARQSDLILTADVSYAQLINRPPKNTAALEDGLMLVGDKGLESLYESFLWEKINAPDQEHFYADHPGYGSQMPLGGDPLTNGQIEFIRQWISAGAPQEGDVIDREVLKDTSWFERVAFQPLPLPEQGYQFHITPFEVRPNSERELFKYQPLNNTEPLYISGFEITMKSGSHHFILYNFPETFAPSLLPNENLIRDVYDASGNYVFTTLYHMQFHQFVAGTQVPKVRYNYPEGVALKVPANSGFDMNSHYANRTDETMEGEVYANIYTTSASEVTHIAQILNLNNDNFYLPAGKVTTIQKTYTFDKDRHIFQLWSHAHEHNTSFKVFISGGERHGELVYFSNDWEHPPILQLDPPLGLKAGEGLMLEATYNNWEDRDLAFGLRSTDEMMILFGAYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D6</accession>
    <name>A0A654E5D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025021733" evidence="1">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15411" checksum="7F76F5C6A003D105" modified="2020-04-22" version="1">MVFFLRTLYVTMYNKLIIASFACLLSLAAWSQSGTGSVVSAETNFYNQPLDISNKIEIYPNPAVEYVIVEISNSTLTNTEFEMHSIIGNEIKISPEEIGNGRFRVPVKDFATGYYFLVVKDEVLRFKKAYRFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5E6</accession>
    <name>A0A654E5E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="16848" checksum="A7ACE92DFF863A2F" modified="2020-04-22" version="1">MVGTLIVLGSMAFALLRLSEFPAIVICIAISFLIPAMWSAYYILEIDPEQKTISEFSWVLSFKNGKTKSFQEVEKIFVNETKKAQRMTSWSGQVRTSKFNEYMAFLKLVEGDKYFLISDPDPANLMKRLTPISEKLGCDIHENYEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5M5</accession>
    <name>A0A654E5M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rplM</name>
        <name evidence="5" type="ORF">MARINOS108_20934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="16321" checksum="349CB804C66E3449" modified="2020-04-22" version="1">MDTLSYKTVSLNSATVEKNWVIVDADSKVLGRVSSEVAKIIRGKNKASYTPHVDCGDNVIVINADKVRLTGKKWNDKQYVRHTGFPGGQRFETPLEVKAKSSTLLVERAVKGMLPKNRLGSKLFKNLYVYAGAEHPHAAQQPKEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5N8</accession>
    <name>A0A654E5N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="302" mass="33224" checksum="B7B396915674D3EA" modified="2020-04-22" version="1">MESIDNITINFSDQNIFILNLSLGFIMFGVALKLTPADFKMVLAQPLGTLAGVLSQFIILPFLTFVLVWILEPHPTFALGMMMVAACPGGNISNFFSALARGNIALSVSLTAISSILAIFMTPINLSFWASMYAPTAALLTEVSLDFWDVFKTIVTILGIPIVLGMSFRHKYPKTAEKLHPYMHFGSIVIFAAIVILAFSANLDIFLNYIYLVVFLVFLHNAIALISGYQLGRIFGLPEADRRSLAIETGIQNSGLGLLLIFAFFQGLGGMAIVAAWWGIWHILSGLSLAYWWNYRVAVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5R5</accession>
    <name>A0A654E5R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="887" mass="101401" checksum="EF76A957FC628D0D" modified="2020-04-22" version="1">MELKPYQQQVINDLQKYLEYLNTYQNPGKAFNQYWADRVGEYEMTLNGPKGMRPYKDNIPGAAHIAIKVPTAGGKTFMACNALHSISKSMDVTCPKTVVWLVPWSNLLQQTVANLSDPDHPYRKKLNSLFANRIEVFEKDQLLQGTGFNPTSVHDQLNILVFSFSSIRIDKLKKEDRKIFQQNGMLEPFRAFIDDTAVYPDSEDTVTLINVIRSLNPIVVVDESHNAESDLSVEMLKALNPSFVLDLTATPKQNSNIISMVNAVALKKESMVKLPVIVYNHHKKEEVITSALHLRRQLEALAVEEEKETGKYIRPIILFQAQSNIKSKDNTTFDKIKEQLVKLGIDEEEIKIKVSSNDELKGIDLMSKSCKVRYIITVNALKEGWDCPFAYILASLADKSSAVDVEQILGRVLRQPYVVQHKKALLNLSFVLTASSKFNDTLNNIVKGLQDSGFSKDDYRAEELALPPKTEDQVLQEELFGQPQEESKSDEAFDLNQVAFNPDAPADLSEADRSFQTLQEITSKAEADAKEFDQKVKEADTDNETFMLSEMGNEVKKYRIEPAFQELAESIKIPQFFIKEATDEDRANVLFEELVPYDVFLSPNKLLREFKLSNQDTKINFDESSADVYKVDYDEIKNTTTIDKLRDNAKNILIGNILAKPKENQIMEVSKLIVSKLGDMTPLSDQELRKYVGRVFEDLSPEKVRDIINNEYIYIQKIKNKIRELQAAEARRQFDVYLNTNKITTQPRFIFSETILPGKEAPSINKSLYEREGAMGKYEQEVIMEIASLDNVVFWHRNLEKGKGFMLNGFDKNHYPDFIIYTRKGTLILLETKGDYLDNDDSRTKNLLGKKWAEKSGEKYKYFMVFETKEVQDTYTAKNIAGVVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Z0</accession>
    <name>A0A654E5Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4279" checksum="0A22D4364F4141C4" modified="2020-04-22" version="1">MNVVNNDILEPHLFTVFFQAPKIKKGNPELNSPLNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E643</accession>
    <name>A0A654E643_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="122"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="254"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="36451" checksum="E3B186EE09457348" modified="2020-04-22" version="1">MNTKLPDHISTELLIRHFSGLASKEEELVLMHWTNTSVENKELLRELHILWADTGAISTPNTDYKKRDIDAAWQKVLAQKPVSPTNGTYTLLKIAAIILVMVGVGYLVRFLQDPQKTYTTHSTVGNIQLEDGSVVALNEASQLTYPGSFSTEERRVALSGEAFFEITPNPNQPFIIEAGPTQIRVLGTSFNVKVDDKSVTVIVETGTVQFTRGNESVLIVQGEKATFSNTTETLSPAQKTSSVGLEQFWRTKSLRFSGEKLPEVIRTIEEAYATQIKLGSEKLSDCSLSVTFNNDTLENILDVIALTLNLEISQTDQQYILTGKGCTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E668</accession>
    <name>A0A654E668_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="32096" checksum="18C13415B3B62B8C" modified="2020-04-22" version="1">MQTFEWRSLQKTDPDHLRAAREQLHQAIQNVAAVGRKFSPKSRYDEYAVLTWVPGLSRLAGQWVSGSVTFRSSLSLESFTIYLVDQKVNVLGSYPVEGQTQLQMMIWLEEQIGKLGLNAANLTMNLPYELPEYPTQSGEPFHMQYPAAALELAKYYHNSYVSLREIKVRMGVENNIQVWPHHFDQALEVVLKNSGDPETDTHILLGMSPGDHLFGSPYFYVSTWPFTDTSQCGRLSNNAIWVSEEWTGAVLFSKHLFDGDQKAILDLFYEEASAQLIELLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6F6</accession>
    <name>A0A654E6F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024868197" evidence="1">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="25797" checksum="68863CBEC9AB9E88" modified="2020-04-22" version="1">MKKVILIMVLISASLLAAAQPDRNEYDTEITWGVNKNTRGGLIGGIVFKLAKQKKEDLFAVYGIEVMNVKHRQEQRYLSPTSGTSFVWGKQNFLYSIRGLYGREALLFKKAPQQGVQISGIVAGGPTIGVIAPYYILYNGNYVPFDSDVHRNFNSIQGSGKLFQGLGESELTIGLNAKAGLSFEFGTFKNNVAGVEMGVTMEAFPKEIILIPTQKNSALFSALYFTMYWGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E796</accession>
    <name>A0A654E796_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yoeB</name>
        <name evidence="5" type="ORF">MARINOS108_11787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="92" mass="10719" checksum="A4B44D1095B1C0AE" modified="2020-04-22" version="1">MSYVLEFSDHALEDIEKHKRAGDQSVLKKLNRLFNELREHPMTGTGQPEMLKHDLAGLFSRRINRKHRLVYGIKEEVVVVYVVSARSHYGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8Y7</accession>
    <name>A0A654E8Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amtB</name>
        <name evidence="10" type="ORF">MARINOS108_110127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="23"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD15984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="429" mass="45274" checksum="393AE7FF194D71CF" modified="2020-04-22" version="1">MFLLFGYQSFAGDEAAIDTGATAWMLTSTTLVLLMIPGLAMFYGGLVRTKNVLGTMMHSFTAMGIMTLLWVICGYSMAFGPNILGGWFGWSSDYFLLRGIDDVITDGIPEYVFAMFQGKFAIITPAIIAGAFAERISFKGYCIFIAVWGILIYNPLCHWVWASDGYLFNLGADGAIDFAGGTVVHISAGISGLVAAIYLGARKQHPHLPMQPNNLVMTMIGVGLLWVGWFGFNAGSSIESGLSTAQALTVTQIAAAAGALAWILIEGFHQGKATALGFASGILAGLVAITPAAGVVQPMGAIALGIFSSGICYLAIMVKNKLGYDDTLDAFGIHGVGGIVGALLLVFFIRESWMEDAAGLAGGTWSVIDQLGVQALAILIALVYAGVGTLLILFVLNKIVPLRATEEAEMKGLDSSYHGEKGYGMINPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA32</accession>
    <name>A0A654EA32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">OMP decarboxylase</fullName>
            <shortName evidence="4">OMPDCase</shortName>
            <shortName evidence="4">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrF</name>
        <name evidence="6" type="ORF">MARINOS108_120331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="30343" checksum="4D961D673709323F" modified="2020-04-22" version="1">MTRQQLFDKIKEKESFLCVGLDTDLEKIPKHLLAAEDPIFEFNKQIIDATYPYAIAYKPNLAFYEALGSRGLASLEKTMEYMPDDVFTIADAKRGDIGNTSNMYAKAFFENMNFDSVTVTPYMGEDSVTPYLNYSRKWVILLAATSNSGSFDFQEVLIENSSEKLYERVIRTSATWSNPNNMMYVVGATRPESLVGVRALVPDHFLLIPGVGAQGGSLSQVCKYGMNRQCGLIVNSSRGIIYAGNGEDFAQKAAKAAQEVQVQMAAELQKHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAZ0</accession>
    <name>A0A654EAZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_140058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="10">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="654" mass="73108" checksum="B0B2EE638A1E2365" modified="2020-04-22" version="1">MKIALVGNPNSGKTSVFNQLTGLNQKIGNFPGVTVDKKSGILKRSHTPHEIIDLPGIYSLYPKTQDEQVVYDILGNQQHADYPDRIVVVVDASNLERNLLLFTQVLDMGVPVTMALNMTDIADKKGLVIDTEKLSELLGGVQIVPIVARTGVGINELVDEIISHKPHQASQPFLGGEFDKGQFLITDNTEQKTRVEKRYRKITQILKFVVKQKPVRKSIINRHRAVDRVLTHPVFGYLIFLGILLMIFQAIYAWAEWPMDLIDTLFLSMSKWVKNTLPEGLLTNLIAEGIVPGLGGVVIFIPQITLLFGFIFILEETGYMSRVVFILDRFMRPFGLNGRSVVPLISGVACAIPAIMATRTIDNWKERLITIMVTPLMSCSARLPVYTLLIALVVPDTFIGPFNLKGLVLLGLYLIGLVAALLIALIFKFFIQTKEKSFLVMELPLYKMPRWNNLVITLWEKVRLFVFDAGKVIFSISIILWVLASFGPGDRIEEAVAAIPEPTSEVSQEEFEQQVASVSLANSYIGILGHAIEPVIRPLGYNWQIGIALITSFAAREVFVGSMATIYSVGENFDTERTLLERMRSEKNSLTGRPVYTLASGLSLMIFYAFAMQCMSTLAIVLRETKNWKYPLIQLVYMTGLAYVAALITYQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECL5</accession>
    <name>A0A654ECL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024790338" evidence="1">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="17330" checksum="EA9D7ADBAB4F7539" modified="2020-04-22" version="1">MNLKNIAPRLFMIVLLAATGCLSSCKDDISGFDLEKDPLKGKIGGEEWQYAAGSANVNSSSYYLEGLIVGESTQDPCAIRVSSKLHLSIKIPGRKGSYNLPFPANEGYVIFNLPNGTKKFTASGGFIEVVAVGSQQLIGYMSADFDDDNTVQGSFLLEFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDD6</accession>
    <name>A0A654EDD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4888" checksum="F8642B9E74AD156A" modified="2020-04-22" version="1">MVFLVETEFKKQYYSRWNIASTFRTQNFLKKNCPLLELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEI1</accession>
    <name>A0A654EEI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ORF">MARINOS108_50035</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="407"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VXD20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="498" mass="53400" checksum="A0DADC2B49358C58" modified="2020-04-22" version="1">MIPILTAQQIRDADQYTIGHEPITSINLMERASRAFVRKFSTLVPGGSRIMIFCGTGNNGGDGLVIARVLIQQAHDVSIFVVGSVERATEDFKVNFERLSVLTGIHQVVNEDQIPSIPDNAVVIDGLFGSGLSRPVSGLFANVIDQINKSGAEVYAIDISSGLYPDQPLGEGAVVEATHTISFQTPKLIFFLPEMRKYVGQWHVVDIGLDEPFIQSCETDAFFTQARDIALPSRSTFDHKGSAGRLLLIAGSKGKMGAATLSARAAMRSGCGLLYIHTPCCGLNILQVNVPEAMVIEDEHTEVITEVMPADNVDVLAMGPGIGTNSLTQKALADLILHTSEPMVLDADALNILALNPELLNALPPESILTPHPGEFARLVGAWRSDFEKLEKLRWLAKTYQLNVVLKGAYSAVCSSRGYLYFNPTGNPGMATAGSGDVLTGIVAALLAQGMAPFDALRAGVYLHGQAGDEAAINVGEISLMASDLIEYLPAAFKKLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFI5</accession>
    <name>A0A654EFI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="32720" checksum="6F77D5D6EB2BCA7B" modified="2020-04-22" version="1">MTNLFVGNSYVLGMDIGGSHVTAGLVDLDNGLIVQDSLRRVELDSQGSTEEILNVWRGIVESCYSDMSKHIGLAMPGPCDYERGICHIDGLSKYSNLYGLNVCETLAHALSIPEENIQMTNDAACFLQGELDMGVGRKYQHPIGITLGTGCGTAKIRHGVGVDGELWQYPFNDGIVEDFISTKWFKRRYSELTGQEISGVKELTEMSNSEPSIRSVFKEFGFNLAKLIGLFVSEENPDAIILGGNMLKAQHIFLPKVQAELTKTGIKEPIHLSTLGESAAILGAASAYVKKKMNLKSKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSR3</accession>
    <name>A0A654DSR3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="476"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="538" mass="61640" checksum="72E94160CB16801D" modified="2020-04-22" version="1">MRFRLHYIILLLLVGTRLMAQDKIKMDSLYLLVNTSKEDTVKINALLEISQLYHHESYQKAMEAAKQASDIATKSKIKAYEAKTVRAIANVYLSMGDYKNASINYFNALLYYEDIKDTLGLLAMHNNLGVIYDRLHEYDKALDEYFKAQMLLNLQKPSAEMTFRLPTLHNNIANIYQTQGDTSSALQYYTSALRLAQESNNQPLQGTALNNLGKLYMVDLKQPEKAIEYLLEGLKVREAYGDKAEIAKSLVILGNYYLRLDQPDKAEPFAKKAITLSEEIGAMETTMNAYLCLSEIEEAQGKLGASLSTYKAFKAQSDSLRDMQANREITRLQLQYDFDKAEKARAEERRQARLRYITIIITLSIGLLIAILITVIIRSRARQTALLQENLTQDVEIKNKELTTNVMYLIRKNELINSVAERLLKLQPNVLPENYKEIHNIILDLQREADNDSWAEFELRFNQVHTDFYNKLHELHPDLSPADEKLCAFLRLNMSSKEIAAITQQSVKSVEVARARLRKKLNLTNTTSNLVTYLSSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DST8</accession>
    <name>A0A654DST8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="18912" checksum="FEED893A68229E78" modified="2020-04-22" version="1">MATQNWNIDPTHSEVQFKVKHLVISTVTGTFKSFEGSLTSDSEDFDGAKAAFTLDAKSVDTNVADRDAHLKSADFFNAEQHPKLTFEGVLSKVGDNYKLVGPLTIKETTKEVELDVELGGTMVDGYGQTKAGFEINGKINRKDFGLTWSMVTEAGGVVVGDDVKLHLNIQVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSY7</accession>
    <name>A0A654DSY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nadE</name>
        <name evidence="8" type="ORF">MARINOS108_10140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="616" mass="69611" checksum="1009B3C91B8736CB" modified="2020-04-22" version="1">MGRTIKIGGACLNQIPMDWSNNLQNIKQSIAQARSEGIEILCLPELSITGYGCEDMFLSEWLPEKALLKLQEIVPHTQDIAVAVGLPIRYHERVFNTTCFIANQKILGVYAKQKLANDGVHYEPRWFTPWESGKITDLQIGQEAYPFGHLTIDYLGIKIGFEICEDAWRKDRPACHLINEEVDLLLNPSASHFAFAKADFREHLVISSSETFHCTYLYTNLLGNESGRMIYDGDILIAQEGVLKGKNTRLSFKNFNTLGCTIDFDQPELSEENILPDANGRHEEFTKAASLALFDYLRKSKSKGFVLSLSGGADSSSIAVLVAQAVKNGLSELGFEEFAKKLNLDLKPSDDPKEIVKQLFYTAYQGTKNSSEDTLSSAKGLAESIGARFFHWTIDEEVSAYTRSIETVLERSLDWSTDDIALQNIQARARSPIIWMLANIKKCLLLSTSNRSEGDVGYATMDGDTSGSISPIAAVDKNFILSWLVYAEKELGYTGLHKVNTLSPTAELRPQDRHQTDEDDLMPYAVLVDIEEKAIRDRKSPLEVYARLKGQWPDHVLLKQWITKFFRLWSINQWKRERIAPSFHLDDFNVDPRTWCRFPILSSGFDEELKELQQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTE7</accession>
    <name>A0A654DTE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="24374" checksum="36CF55D5BC15AB10" modified="2020-04-22" version="1">MITTNKKLTWFIVITQSVLMIWSIGSSILESGPLSAAIISYGLFGVYILYAFITRDSTLSRLILFGLAAGMMELFTDHYLVDTINSLVYPGKEAMIWSSPAYMPFAWANVLIQLGYYGLLLSKWKGWPMAAIILGLAGAMYIPLYEHLAKDAGWWWYHPNAPMIFNAPVYVIICEGLISLSLPLLLTRSSNKGAISATVLGIICGLWIYLSALIAYWIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTH4</accession>
    <name>A0A654DTH4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">hisG</name>
        <name evidence="14" type="ORF">MARINOS108_10385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="51"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="212"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD11076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="285" mass="31521" checksum="C27F20379C73E13E" modified="2020-04-22" version="1">MSNLKVAIQKSGRLSEDSLRLFKECGIKFNNGAKKLKAQSSNFPIEFLFLRDDDIPGYVEDGIADIGIVGQNVHEEYQKQIEVVKHLGFSRCRLSLAVPREEKYSDISFFEGKNIATSYPNILKKFLDTKGITAEIHQISGSVEIAPGIGLAEGICDIVSSGSTLLSNGLKEVETVMKSEAVMVADSKLSDEKRVLLNQLIFRINSVLEGKNNKYVLLNAPNDSLDKIISLLPGMRSPTVLPLAQEGWSSIHSVINEDDFWENIEKLREAGAEGILVVPIEKMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTH7</accession>
    <name>A0A654DTH7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ORF">MARINOS108_10382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="477"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="595" mass="67569" checksum="0EC6ABA64E062B13" modified="2020-04-22" version="1">MELIEKELKQEIVAAFKSLFDFELDADSFSLQPTRKEFEGTHTLVTFSYLKQTKKGPEESGQLIGEYLKSHTSLVSDYNVVKGFLNLSISDSTWLSAFDKIHQDEHFGTFSRNGQKVMVEFSSPNTNKPLHLGHLRNNFLGDSVAKILEASGCEVMKVNLVNDRGIHICKSMLAYEKFGNGETPASSGLKGDHLIGKYYVLFDKEYKKEIEGLVHQGMDPEEAKKQAPLILEAQEMLKKWEDGEEKTVALWQKLNDWVFEGFDASYQTMGITFDKIYHESQTYLLGKDIIQEGLEKGVFFEKEDGSVWVDLTAEKLDEKLVQRGDGTSVYITQDIGTCELKHDDFPFEKSVYVVGNEQDYHFKVLFNIMKKLGRPYADGLYHLSYGMVDLPSGKMKSREGTVVDADDIMQEMFDTAERQTRELGKIEGLTEEEAEALYRTLGLGAIKYFLLKVDPKKRMLFDPQESIEFQGNTGPFIQYTHARISAILRRARTLEVPAEFDTTGITLHPRELELIHKLTDFPKTIAAAARDYSPALVAQYVYDLAKEYNGFYQEVPIFNEEQKEVVGLRIALSKAVAQVIKRSMGLLGIAVPDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU58</accession>
    <name>A0A654DU58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024862207" evidence="1">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="68"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="344" mass="37360" checksum="65F08849024C55DD" modified="2020-04-22" version="1">MMKTYSALCIAVCSMVMACTSPPKSESSESTVPTTFETTGSIERLLPELDLLIPAEAKIEVLASGFTWSEGPLWLKDQNALIFSDVPKNTVYKWTEQDSVSIYLQPSGYDGDRTDKHEPGANGLALDNEGNLILCQHGNRQLAKMATSLDAPKSAFLPITSTYSGKRYNSPNDVAISKEGVYYFTDPPYGLDEWDEKELEYNGVYKMGTDGQVSLLIDSLTRPNGIALSPDERSLYVAVSDPKAAKYYAYELDIDGNITTGKILLDVTPLVGPERKGLPDGLKVDNSGNLFATGPGGVLVISPEGKHLGTIMTGQATANCGFNADKTVLYMTAHSYLMRINLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ1</accession>
    <name>A0A654DUJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug efflux pump subunit AcrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112335" checksum="AB3E7233740C6483" modified="2020-04-22" version="1">MNLTAIAIKNNRVTYLLLGIIIILGITGYASLPRNSMPPFTIRIASIVTVFPGASPERMELLVTDPLEKVVQEIPEVDYIQSESRTGISIIKVALKENVHESELRPIWDRLRRKINNVNVPSGVVKGPDLKDEDLGITYGIALGIKNDGYEPRELEKYADQLRNQLIRLRDAAKVELSGVSERHVFIDYNDAELAKIKLSANELKNAISSTNIIIPAGQISVGDERVILEPSGNFETIEDIQNMLIPVGKGRESVYLKDIAEVYEDYISPRESIVRMNGQSAIGLHISLKEGANIIQLGGEVDELLTSFNQTLPVGITAKRLASQDDSVAKSVSDFISNLIQSMVIVLAVMLLFLGLRTGVVVASLIPTAIVMSLFLMGVFDIGLNQVSLAALIMALGMLVDNAIVMAESMMVKMEKGDKAFDAAVSSCKELMVPLLTSSLTTSAAFLSFFIADSVMGEIMGTLFSVITITLISSWLMALTIVPMLAVLFIKVKKKSKDQKPGFFEKLNIYYKRIIVWSLAKPVLILSVVSGCLALSLVGMGQLGFVFMPDSDRNLVTVDLMLPTGTSLETTDSQVSLLERYLSDSLLINNERSRGVQDWSSFIGEGPKSYDLGYQPDQKQTNYAHLLINTTSGDDNQAVIDQLNQFAFNNLPDAKVTVKRLTSGGGATVPIQIRISGPDAEKLTRMAGETKSQLRTITGTSNVDDDWGPKIKKVNVDINPSKLSYNGLTHQDVALSSYTTLSGYTVGEYRDQEDNIPISMRTEGNLEVAYEDLEGLNIYSQMTGKTVPMAQVADISVDWQLAKIIRRNLNRTITVESQLEAGYTAAEITTQISKWLNEQQDEWGSGYTFEFGGESEASGDAMGAVMAKLPISFFIIILLLVMQFNSVRKTSIVLLAVPFGIIGVVGGLLITGTNLSFTGFLGIISLSGIVINNAIVLIDRIQLELDEHKRNPYNAILAAAQERFRPILLTTFTTSLGLIPLWLGGGDMWEPLAIGIIFGLLFATVITLVLVPVLYQLFFKVSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY6</accession>
    <name>A0A654DUY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/cholesterol/gamma-HCH transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="30655" checksum="F82B1B9D152A224E" modified="2020-04-22" version="1">MLFKKTKSSFCPLVGQTVCVCFVLINFGKANTSDAREYFMKSLGKFLIFAGQLFVRRESFSTYVSLTIDECIKVGYNSLFIVTIVSVFMGAVTTIQTAYNLVSPFIPDYVISLVVRDMTVLELAPTIMAIVYAGKVGSNIAGELGTMRITEQIDALEVMGINSTSYLVLPKIIASMLMYPMLVVLSAFLSIYGGYLTSLATGIISGHDYIYGIRYDFIEFNIAFALIKAFVFAFLVAAISAYKGYFTSGGALEVGQSSTAAVTNSCIAILLADYLLAQLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV15</accession>
    <name>A0A654DV15_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_10929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="6"/>
    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="576"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="645" mass="72520" checksum="8F287EBA97E96917" modified="2020-04-22" version="1">MPFTCLILSLRESELMENHKHFVIDFDSTFTRVEALDVLCEISLRGQPDAQESLAKIKEITDLGMEGKISFRESLENRLEILRAHKSHLPELIARLSDQVSDSFQRNKEFVRKYAGQIYILSNGFKDFIVPIVEHFGITEDRVFANEFTYDEAGNIVGFNKENLLSENNGKPNKIRSMNLKGEVYVLGDGYTDYEIKKAGIAHKFYAFTENVRRANVLQNADHEAPNLDEFLYVNKMERALSYPKSRINVLLLENIHEHGIKKLQEEGYNVKVHPAGMDEDELIEAIKDVSILGIRSKTQVTKKVLESANRLLAVGAFCIGTNQIDLLTCQRKGVAVFNAPFSNTRSVVEMAIAELIMLMRNLPDKSVSMHQGKWNKSASGSFEVRGKTLGIIGYGNIGAQLSVVAESIGMKVQFYDLEEKLALGNAVQCKSLEELLSSSDMITLHIDGRKENNGFLTEKHFSQMKDGVIFLNLSRGPVVDIAGLKKYVLTGKIRGVGVDVFPEEPLSNNDEFISELRGLPNTILTPHIGGSTLEAQENIADFVPGKIMEYINTGSTSNSVNFPNIVLPMLKNAHRFIHIHRNEPGVLAKINHELAAHNLNIVGQYLKTNEEIGYVITDINKDYDEEVIKNLKSIKETIRFRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV34</accession>
    <name>A0A654DV34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsR</name>
        <name evidence="6" type="ORF">MARINOS108_10952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9835" checksum="93645C20E52BEF79" modified="2020-04-22" version="1">MTLQNEPINREQKKDKYCRFKKSGIKYIDYKNPDFLLAFVNEQGKLLPRRITGTSLKYQRKVSQAVKRARHLAFLPYVTDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF4</accession>
    <name>A0A654DVF4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ORF">MARINOS108_11054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="544" mass="60922" checksum="4FD32E89B8614623" modified="2020-04-22" version="1">MNEKGLKSQKVGLEAAGILKVKEAFWNLNAAELIEDSVRNGEGHLTDTGALMCDTGKYTGRSPQDRFIVEDAKTQDKVWWGDINRPVSPENFDKIHAKMLKFLEDKKVYVRDAYAGADKTHRLKLRVVNTLAWHNLFCYNMFITPPDYKLQDFDPNFTVICCPEFEADPKTDGVRQGNFAIINMTKRIILIGGTAYSGEIKKGIFSVLNFLLPTEDHVLPMHCSANMGVEKHDTAIYFGLSGTGKTTLSADPERLLIGDDEHGWTNNNIFNFEGGCYAKVINLSEENEPDIFNAIQYGAILENTRFIPNTRTVDYSNTEVTENTRVSYPIESIKNIAKPSVGGLPKNIFFLTCDAYGVIPPIQRLSKGQAMYHFISGYTSKVAGTEAGITEPVPVFSACFGAPFMPLHPTAYAEMLGKKMEENEVKVWLINTGWTGGPYGVGSRIKLKYTRAMISAALSGVLENVGYRTHSIFGAEMPLTCPNVPNEILSPRETWKNDEAFYKKANELALKFNRNFDKFREYASKEILEGEPQPNKKYPMKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVN1</accession>
    <name>A0A654DVN1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4435 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029492">
        <property type="entry name" value="DUF4435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14491">
        <property type="entry name" value="DUF4435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4435" evidence="1">
        <location>
            <begin position="25"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="34270" checksum="026E019092A5993B" modified="2020-04-22" version="1">MEDHITPDRIANAICMDTTFQGYHVIVEGKKDYKFYSKFFNSSEIRIVEAFGNERVIEVLQLLDDRGFNRDIGIIDLDFNRILGIDHQIDGLFVTDDHDIEVMVIKTDALVDVVNQYCSPKSIKDFESSKSTTIREELLKIGREIGYLKLAAKVYDLGLVFKPKMADGNQLRYNKLMDNNFDFAGKNVLIETIVNFSNGKSDCIKSQAEINMAFDAIKQKSYPDYELVNGHDLANLLYLLMKKVLKSKSKSLGDWDCVEDSLSLAYDSSDFKKTILFKELEKWRISENVNLFSERITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW31</accession>
    <name>A0A654DW31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02757">
        <property type="entry name" value="TIGR02757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="30299" checksum="391E87641CE9F3ED" modified="2020-04-22" version="1">MTKIPELKAFLDEKVTQYNQPGFIENDPISIPHEYTRLQDIEIAGFMASILAWGQRVTIINKCREFFERMDNAPYDFILNHSESDLRAFLDFKHRTFNATDALYFIEFFRHHYSQHESLENAFVRGALVGASDTYSHLAGFFEYFFSIPDHPRRTYKHISSPVRKSACKRLNMFLRWMVRQDTSGVDFGLWKVIKPSQLVCPCDLHVDRVARSLGLITRKQTDWQTAIELTNQLKAFDPKDPVKYDFALFGLGVEEKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW33</accession>
    <name>A0A654DW33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845955" evidence="5">
        <location>
            <begin position="29"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="37"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="6">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="359"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="573" mass="62117" checksum="205636285E80DBF5" modified="2020-04-22" version="1">MKTLLQNQSIKITLLLTLGLCSSMFTQAQNWNLVWADEFTNGIGPDWVFETGTGSGGWGNNELQYYRQQNATVENGQLVITAKNESFGGMNYTSARMKTQGRKSWKYGKIEARIAMPSFLGVWPAFWMLGDNITSVGWPSCGEIDVMEHVNTEAATHGTIHWQDHNNSYANYSGSTGTNVTAFHTYAVEWDANAIKWFLDGNLYHEASIAGGVNGTSEFHNNFFILLNMAIGGNWPGFNVDNGALPAKMYVDYVRVYQSGGGSSNGVATLFQHCDYGGYSASLNPGSYTLGQLQALGVSNDDISSIQIQSGYQLTMYQHNNFTGNSLVKTSNDNCLVNEGFNDNISSVIVAQASSGWSATIEAENWTVQSGTQTEACSEGGQNVGWIDTNDWMVWDINPPSSGAYTVEYRVSSPNSNGMIQLEKAGGSPVYGTKSVQNTGGWQNWTTVAHTISLSGGQQQIAIKALTGGWNINWFKIKSAGGSRVVSEPSVPEPTPEISLSIFPNPASNLLNIKGLKGLGNYQIYDLSGKTVLGGILSSEDGLSSTIDVSSLNTGSYFLVESLSNTKMRFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW37</accession>
    <name>A0A654DW37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="194"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="34704" checksum="5C9D3E56853516C0" modified="2020-04-22" version="1">MHNIKSISEYHQLANLPKPEHPLVSLVDYSQVNYQTDGDEISIVSGHYSIALKRGMSGKFRYGQQPYDFDEGLMSFVSPGQVITVKVHREPNPHPTGWILLIHPDFLWNTPLATRIKNYEFFGYHIHEALFLSEKEEKSMIGIMENIREEYHSNIDQFSQNIIISQVEVLLSYAERFYQRQFITRKISNHEILGRLETILRRHFAQGNLASVGLPVVEEIADQLNVSSGYLSSLLKIHTGLNTQQHIHEKLIEKAKEKLSTTQLSVSEIAYSLGFEHSQSFSRLFKSKTKLSPLEFRQSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW87</accession>
    <name>A0A654DW87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein Soj</fullName>
            <ecNumber evidence="2">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj</name>
        <name evidence="2" type="ORF">MARINOS108_10941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="27832" checksum="23DA59FCA9227B79" modified="2020-04-22" version="1">MGKIIAIANQKGGVGKTTTAINLAASLAALELKTLIVDADPQANATSGVGKNPKEVEISIYECMVDGADAEKSIVSTDIKFLDLLPSHIDLVGAEVEMVSVSQREGKMKEALSKVKEKYDYVIIDCSPSLGLITVNALTAADSVIVPVQCEYFALEGLGKLLNTIKIIQNRLNPELEIEGILLTMYDLRLNLSNQVVEEVRTHFKSMAFETLIPRNIKLSESPSFGVPAISHDAESKGSLAYLNLAREIMQRNEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG4</accession>
    <name>A0A654DWG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">mgsA</name>
        <name evidence="4" type="ORF">MARINOS108_11055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="14619" checksum="CEF2206ADFBF8C18" modified="2020-04-22" version="1">MAAIFYFAPMKIAIIAHDGKKAEMVAFLLKYKDWLEKVELVSTGTTGSHVEKAGLKVHRYLSGPLGGDAQIAAEAAEKKLDMVIFFRDPMGKHPHEPDVQMLMRICDVHDIPLATNPAAAGLMMNSLLKKIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN9</accession>
    <name>A0A654DWN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="26817" checksum="45CB919D5335FC72" modified="2020-04-22" version="1">MSKVWIITKRELASFFDSLIAYVMIVLFLGLSGTFTWLVGTNVFLINQASMQVFYSIAFWSLFFFIPAITMRMIAEENRAGTIELLITKAVSDSQIVWGKFLACFILVIIALVCTLPYYITISQLGNIDDGAVLGGYLGLILLSASYISIGLFASSITQNQIVAFLMAMSIGIFFQLLFDVIGGSVRGFFGELFSYLSMSTHFESMSRGVVDSRDLIYFFSIIASGVILSQVMLSKRNWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT6</accession>
    <name>A0A654DWT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Histidine kinase</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="143"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="270"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="345"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="583"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="636"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="753"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="830"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="907"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="873"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1119" mass="127561" checksum="66C29E44FB70553E" modified="2020-04-22" version="1">MKDSTNHITLDILNNLPGLVVRYQLHSDHTDEIVFANEAASLLFGSKSGLVDATTFWEKVHPEDSEPMHQSFFCSAEKLTQWEFEWRVKTNTGSIIWLWGTGNPSRQKDGSTVWDCMISDITSRKVLSETSKPLAADHALREDSERLLSLLNNNTEESFVLLNKDLRVINYNEQFLKKFGAYLGKVIRKGDLILDHVTSEQRKPLEELYSRVLQGQEESKEFSISVDQELLHFQIKYKPVSDENGRITGVFVTTADITDRKRAEEQLALNNSLFRSLVENGADAVIIIGPDGIPTYASPSITKVLGYTEAEALSLNLFEMVHPDDVGGVAEKMAEVMANPGVTIPGHTSRTRHKDGSWRWMEATITNMLHDPIINGIVDNFRDVTEQKELQDLLKNASELAKIGSWEVDLVKNSVYWSDITKKIREVEPDFEPDLDTGISYFKEGDREIIASRVKECIENGTPWDEELQITTFKGNSKWVRTIGRAEFSQGKCIRIYGSFQDIHDTKIAQLDLLKFKQVIENSRDGIALANPQGKSIYLNPAMEETLGYTIESLQKAKGSVAVYSDPQKLEEVFSTLLSGGYWKGDVELLNKHKEPVSFYLSGGPIFDHTGQLIAIYGIHTDITDRIRAEQNLKKAFDEKNQILESIGDAFFTTDRNFTVTYWNGIAEALSQTPREKIVGKNLWEVFPEGLSMQSFEKYHYALSEMVTVNFEDYYESLGKWIEASAYPSEQGLTVYFKDVTERNKAREAIHQSNDRFKKVSEATNDAIWDWDVINDTLFWGEGFKTLFGHEMRENQSSTFLWSKYIHPDDLDDVLASLFDVLENNTTKKWEKEYRYLRSDGSYAFVVDRGIVIRDGEGKAIRMVGAMSDITHRKEYEQSLKILNENLEKQAKDLATSNAELEQFAYVASHDLQEPLRMVTSFLTRLESKYATALDEKAHQYIHFAVDGAKRMRQIILDLLQFSRVGRHEDDLELIEVQEIVAEVVTLQKKIIEEKQANISIGDLPTLRTFRSPLLQIFHNLISNALKYTQEGRPAFISITCYSTKAYWQFSVEDNGIGIEPEYYDKIFIIFQRLHQKEEYGGTGIGLAVVKKLIDNMGGKIWVESIPGEGSSFHFNLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV4</accession>
    <name>A0A654DWV4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hppA</name>
        <name evidence="11" type="ORF">MARINOS108_11190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="778" mass="81450" checksum="B770ADBC4BC94669" modified="2020-04-22" version="1">MSYLIYAVPVLALIGILVMIVKSRWVNKQDAGEEKMQTIANHIKEGALAFLSAEYRVLAIFVVIAGILLGVISALVETTHWFIVVAFVIGAIFSAVAGNIGMRIATSANVRTTQAARTSLSKALKVSFTGGTVMGLGVAGLAVFGLSMLFILLFGWLMGGQWTNTDDMTIVLEALAGFSLGAESIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGMGADLFGSYVATVLASMVLGNYVIRDMGGSIDDSFNGIGPILLPLVIAGLGIIFSIIGTFFISVKDENAKEPQVQAALNKGNWSSIIITGIASYFVIDILLPKNMKMDFFGMGVIDIPSSNVFYAVLIGLFVGAAISFFTEYYTGLGKKPVMDIVRNSSTGAATNIIAGLSTGMISTFAPILLFAGAIWGAYELAGFYGVGIAASAMMATTAMQLAIDAFGPIADNAGGIAEMSELPKEVRERTDILDSVGNTTAAVGKGFAIASAALTALALFAAYVTFTGIDGINIFKAKVLAALFIGGMIPVVFSALAMRSVGKAAMEMVKEVRRQFREIPGIMEGTGQPEYSKCVDISTKAAIKEMMLPGALTIITPILIGFFMQAEALGAYMAGVTVSGVLWAIFQNNAGGAWDNAKKSFEAGVMIDGEMTYKGSEAHKAAVTGDTVGDPFKDTSGPSMNILIKLTCLVGLVIAPILGEIHGASGHGKAAVEIVDPVVIKKEVKVKVEGEDESNMKAEITITEGENTTTETLEGSKEEIEKKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX20</accession>
    <name>A0A654DX20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="760" mass="89651" checksum="F6A5116A785A0F96" modified="2020-04-22" version="1">MEKLFDSAKKHILTFLNETFDLEVSESTLTIIFYSLLILGTSVLIPLFKKVRAWYSYKRVTQRQNPYYQPYEFRDAYRFYVHTKFQNIPPSYEEEPYFSQASVARQKLIPFFLRTFSNDRNKHKYYIILADSGMGKTTFMMNLYMRYKRRLFKHFDMYIFPLSQPDIEKDIENISDEQMCKSIILLDAFDEDLNAARDYMNRIEELVKLTSKFRFVVISSRTQFFPIEEVEPGEIRIRKHGSVGGFHTFKKIYLSPFNDSDIRKFLLKRYPIYRVNKITRAFRLTRDCPYLMVRPMLLNYIDDLLDHQDSFNSIYNIYSLLIESWIDREANRKRQVERAIFKQNLYEFSEKFAVELYNNFYAESSLRVPAQSVITFAQESNINLSDLELKSKSLLNRDGRGNYKFAHKSILEFFLAKIAFSKHFFLREFNFSSFTFARQMYRDLCKINYDQNKSNLSYRLDSKSHGEFIGNKMGVLTPSTDFLQHVSGVVHNRVLSLIQFDLTDDYLHFIKMMTEVVVLNLSSNRLTNLETLNALTGICDLYLRDNTIITFSLRSFPKLTVCDLSYNALESFHIDSSSIEELDLSFNPITRLTFSDVSNLRILNLSNTQLNEVPQLPKSVHIIKDNEFDLLLNDSRSKVIKSRRVKLEMELKTLAFGVFNKCTHAHDHIVYYRVRIDGVKKQSDYDGRFDYADGLDHNNLLAIFKILPLVETKNHKPQLDDMNFVKKLSEGIQLELDHPTFSLVRFGIKNESLCMHLMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX78</accession>
    <name>A0A654DX78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylneuraminic acid synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFP-like" evidence="2">
        <location>
            <begin position="406"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="750" mass="85081" checksum="854BBF6DE4C9A7DD" modified="2020-04-22" version="1">MIIDRNIYKYIIYQEETIHNSLKKINEQKGRILIVVSERDIVMGVATNGDILRWLVENDMPDLGQPISSIANSKFKFVRDTDHPSRFQELLKEVNFLPLLNESKQLLGVVRKDHPAEGIEIGSHHIGKGHPSFVIAEIGNNHNGDISLAKQLVDAAASAGASCAKFQMRNLNSLYANAGKADDIKENLGSQYTLDLLSKFQLSNEQLFEVFDYCKLKGILPLCTPWDTESLNALEEYGMPAYKVASADLTNHGLLRQLALTGVPIICSTGMSIESEIIETENLLQSLGVPHVMLHCNSTYPAPFGDINLNYLHQLKEIVNCPVGYSGHERGIHVSIAAVALGAQVIERHITLDRTMEGSDHKASLLPKEFAEMVKGIREVEESLGAREVRKISQGEMINRVNLAKSLIINQPLKKGELIEEHMVEVKSPGRGLQPNYLNALVGKRAKHDFNQYDFFYPSDIEEEEVVKRSYKFNRPWGIPVRYHDFKEIIEGTNADLVEFHLSYKDLEVDIRQFVDEQLDLDFVVHSPELFEGDHTLDLCSLDETYRQRSIEELQRVIEVTKQLRPYFKRSVKPLIVTNVGGFTSQGFLTEQERIKRMRILEASLKELDTEGVELIPQTMPPFPWHFGGQQYHNLFVSAGEIADFCQRNDMRICLDTSHSKLACTHYKWSFHQFLEEVVPYTAHMHFADSENTGGEGLQIGEGEVDYHAVGEVINRLNPNASFIPEIWQGHENRGEGFWIALERLEHLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX81</accession>
    <name>A0A654DX81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterol desaturase/sphingolipid hydroxylase (Fatty acid hydroxylase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="413" mass="48434" checksum="B146EABD535B1CF7" modified="2020-04-22" version="1">MNVYTFITPIVLVLLLAEIIYSVRTKKPYYDFQDTITNLATGIGNQCVNLAVAFFVFKWYGWLYQFAPWQIPNTWYFLLLLLLLQDFVFYWFHRTGHTINVFWAAHMPHHSSEELNLSVGIRASFTQRLFQFVFFDWILVLIGFSPEAVYAIAAVHLLLAYWHHTQVIKRLGWFEKYFVTPSHHRVHHGVNPQYIDKNYSEFLIIWDKLFGTFEEEDEEICYGVTHPPRTWDPIFVNFQYWKQLWDDAVAAPYWWDKIRLWFMPLGWRPRGLETEKKDRIGYTKAEQVKYHSAQYKNLKPYLMAHVAITLAYLMVVINLSSPLSALDRLILSSGVFMTIISWGGLLQARTWSIPLEVLRTAFMAIALILVLNQNEMANWTSWTTIVILGITGVSILYFSFKIKKGQLESVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX94</accession>
    <name>A0A654DX94_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4159 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025297">
        <property type="entry name" value="DUF4159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13709">
        <property type="entry name" value="DUF4159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025073167" description="DUF4159 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4159" evidence="2">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="25257" checksum="3B1BA7C9BDF81C33" modified="2020-04-22" version="1">MLNSILKNLCFCLILLAAVTVEAQTLRVAKLKYDGGGDWYANKTALPNLISYCNEHLKTDIASEEEIVEVGSPDLFLFPYVYMTGHGNAVFSSQQAENLRNYLTSGGFLHIDDNYGLDPYIRLEMSKVFPNLNFVELPFDHPIYHQKYDFPEGLPKIHEHDGKPAQGFGLFYEGRLVCFYSYESDLGNGWEDQVIYNDPQEVRLKALKMGANIISYVFTTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC4</accession>
    <name>A0A654DXC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024792232" evidence="2">
        <location>
            <begin position="24"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="592" mass="64608" checksum="6F4626CA2C5B5A45" modified="2020-04-22" version="1">MNRIKLFAIYLTLGGLLAFNAEAQKLPFGKKDDANDDPKEEATEEESGGFGGKLKAKAKNFNVMKSLGKLAGNLLTSTTDDLSTLSMQVIYMQNLYPSETETIETEYFGFWEPGMDMAGVLFLKKEGVGMSKIDGTVNIDGNLTEHVANGFYGGIVSQNSGAHTVNVSTVRGDQAELKADPIEPIEIISVNGKPKGEVVDVNMDEDLVLELNHPEGGTADFYVAVLGKVMGIRGFNEIGFFKSTTKIIIPKEAFRHTATTAYKFEQGSNYLLVQRTKEKVVNLPALGAAQVISGAMDWSPINLVGDQKTFLGIGTDEFNAGYKAKTKDGFEVNANKPNAFWGPPLSEPKKLAMASFVVRATQLKQQQVNTSTSTSGNVTTTTTTTTTKTFPEVPEAYWDQLVNEFYKKFETALLEQMNVQLVPIETTMKASQYQNLFATMDTVSEEIVVKPYKGCKLLLPTTFSETWASRTSTFPSDKPEIKLLEELGVDGIISVTVDCAMSWEDGSLSPRMSFRINGPTNGWKVGPTTYANGLIAGPGQGVSETAKNAADITDQLNQIMNVDRVIALFTEAMEGLKADEANKGYEKIWALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI2</accession>
    <name>A0A654DXI2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="17063" checksum="BEDACB0D5D32482E" modified="2020-04-22" version="1">MAINDRISDLIGELHTNPNSFADNIGVKSPVIYNIIKGRRSKPSFDVLQKILMAYEAINANWLLKGEGEIWKEKENNFALDTGYASIEDRIVSLVSALREEIGLSPSLEELSELIGTLLTENMKQKEKIAALYVKQDKILEVLRNKLNLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN8</accession>
    <name>A0A654DXN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phaA</name>
        <name evidence="7" type="ORF">MARINOS108_11436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="270"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="392" mass="40974" checksum="832DB2DB4286AC0A" modified="2020-04-22" version="1">MEEVYIISAVRTPIGSFGGSLSGFTAVELGSKAIKGALDKAGVSPDQVNEVFMGNVISSGLGQAPARQAAIGAGLGYNVPCTTVNKVCASGMKSVMFGAQSIMLGINDVVVAGGMESMSNVPYYIPKARFGYKYGHGQMLDGLMHDGLWEAYHGFPMGSCADNTAKEMNISREAQDEYAINSYKRAAAATEAGKFKDEIIPVEIPQRKGDPIIMSEDEEYKNVSFDKIPVLRPVFNKDGTVTAANASTINDGSSALVLVSKKKLDELGVKPLAKIIGFADAAQEPLWFTTAPSEAIPRAIKHAGLTASDVDFYEINEAFAVVALANNQKLGLDAEKVNVNGGAVALGHPLGTSGARIITTLHSVLAQNNGRIGVAGICNGGGGASAIVIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP2</accession>
    <name>A0A654DXP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4257" checksum="DC26C2B55CD18561" modified="2020-04-22" version="1">MRKNSRLNYSLSIDQEEPPIGEAFFVGGGGKIIVWPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR5</accession>
    <name>A0A654DXR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="676" mass="70370" checksum="B681F1E6E37E5DA6" modified="2020-04-22" version="1">MKLIKYINSLNILSLALVCILGASGLLMSCEEEDTMGSEVVLLSYGPSGVRHGDTIKFIGLNLDKVSAIVLQPEIEITDFLTKSSTLIEITVPKAAQAGLVTLKTKDGDIETKSPLSFEVPVTITSITAEARPGSTITVTGDLLNWVESVTFKDGLLVEEFVSQSLTELVVEVPMEAQTGFLIFSSGGTDPLTFASENELVVTLPAVTSLSPTAVRHTENLTINGTDLDLVTSIGFGGDLTVTKDNFVSQAASKIVVAVPAMTLKGTLTLNQLSPVSVVTSQSLTIVLPIGTAAAPAVAVPGVDNLTITGTDLDLVAQLSLPSVDPIAAANFVSHSPTEIVLSVPEGTKSGGITYTTIHGYSANLGVNVVVPGAGPAPLGLTLYDDEVFFGGGDWSWNTDVSDNASTEQFYSGSKSWKYSTASDGGVSAGGMSGVDATGMNVFAFSIYGGPGTDGASLAAILGSDGADVWGNYNSVTISEGEWTEFEIDLANYPDVNLANVTRWIFKVEGVTGTTIYVDRVGFDLGGPKPLAIDMFDESVNFGGGDWSWNTDVSDNANTEQAYAGSVSWKFSTASDGGVSAGGMTGVDASGMSVLSFAIYGGPGTNGASVAAILGSDGSDVWGNYNAVTITEGAWTEFNLDLSNYPDVNLANVTRWIFKVEGVTGTTIYVDRVGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS1</accession>
    <name>A0A654DXS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="267" mass="30958" checksum="B3C52309C572CDD1" modified="2020-04-22" version="1">MHHIIDEDWPEAMKVYCQRLIELFGMPIPGLSQSGNTLSVRYSKGNHSFKDSKYFLDPKDQSFSHLTTYRGLFSIINSGVLRLYNLNNSNDPNELFSLAGIPTYENVSENIKPYVYTFSFCKASQVANPAMWRDYGQVSLNFEIVNDPLAWEYYRISPLHYGGSEFVPKYVVLLDEMHKRFPQWNFSPDLESLLSLLAFHKESAHKHEEEIRLLYVPFMFDDRGEAQFDFRVSEVRTGATKFIELQLLAADEQKAIDHCLTKGNLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT7</accession>
    <name>A0A654DXT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 109 protein</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024802371" evidence="1">
        <location>
            <begin position="28"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="50536" checksum="8CE3E01B79A49103" modified="2020-04-22" version="1">MNKMDRRNFVLKTAAGASLAMMAPSFAFGLGKGQDKIRIGFIGVGARGTGQLGLTLQRKDILVTAVCDIDQERLANASKMVQDAGMKKPATFGAGPYDYQKLLQREDVDAVIISTPWLWHTPMAIDAMEAKKAVGLEVAGAFDIQECWALVDAYEKTGTPFMILENVAYRRDVMAVLNMVRQNLFGEIIHLQGGYQHDLRHVKFNNGQQLYGGGVEFGEKGYSEARWRTNHSVNRNGDIYPTHGLGPVANYINNNRGNRFVYLTSTSSKARGLHEYIVEHPQGGKSHPNADVEFKLGDIVTTVIKCAQGETIVLSHDTNLPRPYSLGFRVQGTDGIWMDLNDGIYIEGKSPAHEWESDAAYMKQYDHPLWKKYESDSAGAGHGGMDFFVIHAFVEALKRNEPMPMDVYDCVSWAAVTCMTEQSIANGSAPVQFPDFTRGKWLTRKPIFGFDDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV4</accession>
    <name>A0A654DXV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sialate O-acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="4">
        <location>
            <begin position="105"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="3">
        <location>
            <begin position="274"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="4">
        <location>
            <begin position="407"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="644" mass="72286" checksum="8FD65B110850A7B2" modified="2020-04-22" version="1">MRKVLKSLLLPLLLLLSLCTTGQLRLPRLVSDGMILQRGADVKIWGWDTPNQAINIDFRDVTYLAKTTPEGTWEIKLPSLEAGGPYQMTISGSEVITLEDILIGDVWICSGQSNMELTMQRASPIYAKEIATAENPLIRQFNVSTRYDFKKPQSDFEKGEWVKATPETVMSFSAVAYFFGRALFEKYQVPIGLINTSLGGSPAEAWMSEKTLMEFPKHFDELQRFKDDDLINEIQNSDNERIGAWYRTLLQKDAGNKNTPWNTPDLNTDAWPSMPIPGYWADQPIGPVNGVVWFRKEINLPPSMKDQPAKLLMGRIIDADSVFVNGVFVGTTSYQYPPRRYEVPAGVLRAGKNILTVRVINSSGKGGFVPDKPYTLTVGHKTIDLTGDWKYQLGAEMELLGPPTFIRWKPGGLYNGMLAPLFNYTIKGAIWYQGESNASRAKEYRTLFPAMIADWRTQWDQGDFPFLFVQLANYMETKATPGPSDWAMLREAQLQALSVPNTAMAVITDIGEWNDIHPLNKKDVGNRLALAAAKLAYGDDLVHSGPVYKDFQIKGNKMILTFEHTGSGLKIKGEELKGFAIAGKNQKFVWAKAKIKGNQITVWSADIKEPVAVRYAWADNPDQANLYNQEGLPASPFRTDQWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY34</accession>
    <name>A0A654DY34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="8191" checksum="103BB6CA8F36B054" modified="2020-04-22" version="1">MSKSIFYHAGCPVCVSAEHDILNLLNPKEVEVIHLGEDKTKIGDAEKIGVKSVPALVTPNGHVLHINFGASMADVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY88</accession>
    <name>A0A654DY88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formylglycine-generating enzyme</fullName>
            <ecNumber evidence="2">1.8.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.3.7" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:Formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="38384" checksum="F2028F02855DF8DA" modified="2020-04-22" version="1">MRLLKFGMVCLLAAGCSQADKDRGSIEAPEGMVYIPEGSFHMGAKSTEAYEDEFPSHEVSVSPFFMDATEVTNAQFAEFVEATGYVTIAERDIDWEEMKTQVPEGTPKPPDSVLQAGALVFRPTSSEVNLADYTQWWVWTIGGNWRHPEGPESTIADRMNHPVVHVAWDDAVAYAQWAGKRLPTEAEWEWASMGGRKDIKYPWGNESAENASDKANFWQGKFPYQNYVLDGFETTAPVKSFPANGFGLYDMAGNVWEWCQDKYDARAYESYQRKGAVEDPKGSAQYYDPRDPYTPKHLIRGGSFLCNDSYCSGYRVSRRMSSSKDSGFNHTGFRCVQDVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI8</accession>
    <name>A0A654DYI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025022626" evidence="1">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="18384" checksum="5E07BE37E9C43632" modified="2020-04-22" version="1">MMSVKKAAGLVGLLLILQIPSLAHSEMAGQLIFENFKNELYVKSIIDKRMLSLALMQEADCTPDQMISICGDEYLQEHIQITVNCQPVTYEKVSVTLEKNAVVYSYRMIKADEPITSVSVTSDFLLRYNEHAFVRAQFAIDNISKSFDLKASKKTIEANFIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI9</accession>
    <name>A0A654DYI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="159"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="39843" checksum="D1D1DCC5FCF0FB88" modified="2020-04-22" version="1">MKNKSIKTVRFLGLGFLEPLIRLFSGEEPARNGKLFAKKALLPLFSIILFIGLWHIGATALYNSEAAVRIEKAREEQGEAAATAMKECITSGDVSCQPNTLPSPTKVYQAYLALWQDHLAIAQKKSDFKTRVSATNAQREAQGLAPITYTGRPSFLDQVGTSLKTVAAGCLLAMLVAVPIGIIMGLSNSLRTSFNWLIQIFKPVSPVVWLLLVFMIVKTVITDPSMDKSFIISFISVGLCAMWATLVNTSMGVATVDKDYINVARVLKLNIAQNIFKIILPASLPLIFTGLRITVSVAWMVLIAIELLAQSPGLGSFVWEEFQNGANDSNAKIIVAMFIIGLIGFLLDRIMLSVQNLMSFNKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM2</accession>
    <name>A0A654DYM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="14242" checksum="87056C3A76749F15" modified="2020-04-22" version="1">MQNDPTLDPKYLGKISSDFVKVSEYLKEASYLIRKKGFSEYPVFPVSKEDVPIGQLLYEKGKLENEWNYYASFMEEFAQRQLIAEEAKFKEAYKDPDEYCCLFIVDREFTNFLFIPFPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU7</accession>
    <name>A0A654DYU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="23654" checksum="27C9A52BFBA3FF3D" modified="2020-04-22" version="1">MVKTIKKQVGKQASIRVNIDKTWSANEFATFFRSFESLYSLYLFYFEGCELVKNKKKNKTYYAKQQHTPLFHFLATKSLISSFYHEEGIFQDGNQSFITSTSKVDSGLSVTSIRFSSPGFTDFTGLSGVVGHLKEVFMYYFPNKLAKEEIKIKQQKRVNLQIKNLKAMGFSSTDIKKIVLLEEMTIDKMKLLIDEGKITSIESNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV8</accession>
    <name>A0A654DYV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="12323" checksum="9750256073601814" modified="2020-04-22" version="1">MKDLQLGEFEEIVLLTVAILFGDAYGVTLKAEIESRLNRKVSIGALQSALRRMEEKGYLNSEFGEATAMRGGKRKRFFTVTDLGKKALAVSRDTRNQLWDAIPDVAFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ14</accession>
    <name>A0A654DZ14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="449" mass="50671" checksum="AE10D4C317B7FFAA" modified="2020-04-22" version="1">MMRKDRRNFIIKATAGAAGIGLTSQLNAMSAKSYSKIIGANDRIRVALQGLGRRFPAYKDAIADKNNNVELTYLCDVMKSQRERAAAMFAEVTSDKPKLENDIRKVINDKKVDAIFMATPDHWHAPGACMAMQAGKHVYLEKPCSHNPREGELLVAYQKKYDKVVQMGNQQRSSPQSQEIIKDIHDGIIGDVYQAIAFYTSRRGAVPHQTPASPPEGLDWELFQGPAPRRPYTDNTWDYNWHWYGWNYGTAETGNNATHELDIARWALQVKYPERVEVNAGKYQYKDDGWEMYDTMEATFKFSGNKVIQWDGQSRNGYYKFGAGRGTIIYGSEGSVFIDREGYKLYSLKGELIRENLSSGTEAGTALGGGGDMSTMHTKNFFDAIRGKAALTSPIDEGAISQMLTHYANIAYRIDDAYEVDENTGRIYNREAMKLWSRTYEPGWEIKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ87</accession>
    <name>A0A654DZ87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024847427" evidence="2">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="205" mass="21887" checksum="10604135288D91F0" modified="2020-04-22" version="1">MKKNQYLKAFAAFGLAAVLFTSCGDVPQAEIDQATLAINEAKAAGAEVYATESYLALEDSMKAVIETVEAQKTKLFKNFTASKAGLASVAQLATMVKQETETTKEELKNQIQAEIAEVKSLIEANKQLITEAPKGKEGTTALLAIQGELSTIESTVSESGSLFEKGEYLASLDLTKAAKEKAAAINTELQDVIAKYKANTKAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA0</accession>
    <name>A0A654DZA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-regulated ABC transporter permease protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="49014" checksum="1D63C287346FCF4D" modified="2020-04-22" version="1">MSEVLSIEQTISEQFQQWAGQHFADESPLKALKTSALEQFSTLGLPAPKSEAYKYTPISRILGKQFDFAAETTPASFSKADCQSQFYQIADANHLVFVNGLFNEEYSTIVSPSSDLTIRVLDDQALKEHSDIPQLLGKISHIETDAFALLNLAFFNQGIYLKAAKNKDNKDTFIYHFIDGTAKDAIVYPRILVSSETGSRLNIFEKTFIRGEQNTLNVSIFEADVQANAELRYTKIQNYLTGTYAVEGIYATQKKDSRFYTNTFSFKAALIRNNIYINVDAENCEAHMNGLYQLGGKTHVDNNTSVDHLKPNCFSNELYKGILDENSRGVFNGKIYVRPEAQKTNAFQSNNNILLSDTATVNTKPQLEIWADDVKCSHGCTTGQLDEEAIFYLRSRGINKKRAKALMLNAFANETLQEVKNDLVTAEIEDIITNKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA6</accession>
    <name>A0A654DZA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5570" checksum="CCAF7AA2B469F52A" modified="2020-04-22" version="1">MPNLLGDLILYKTQECLIKIFQLSLRFIKLGLEYLNILENEKSVGQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA8</accession>
    <name>A0A654DZA8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="3 6">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gnd</name>
        <name evidence="8" type="ORF">MARINOS108_120044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3 6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="7">
        <location>
            <begin position="179"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="50842" checksum="D13ED2933903C46C" modified="2020-04-22" version="1">MADQYDFGLVGLGVMGRNFILNVADHGFSSMGLDTDDEKVNALKAEGAHVNVNGSTDSVTFLKALKTPRKIMLLVPAGKPVDSVIETLLPNLEKGDIIIDGGNSYFEDTERRITYLEEKGIHFFGAGVSGGAKGARRGPSIMPGGNKEAYEHVRTIFEAASAKVNDEPCVEYMGRGSAGNYVKMVHNGIEYGLMQLISEIYDVAKKGIGYSNEKLAHLFDEWNRGELQSFLVEITAEIFKKKDDLTGKDLVDMILDKAKQKGTGKWTSQNAMDLGIPIPTVDAAVTMRAISALKDQRVDADAVYHTPSLGNDKPDAQTLEHALQFAYIVTYAQGMSQLAAASKEYNYGLNLETIAKIWRGGCIIRATLLEDIRKAFDKNPNLANLMLDDNFVKTLKTIEGDARIVVQFAVGSGIPVAGLASAVSYFDAFRSGNLPLNLIQAQRDHFGSHTYERTDREGIFHTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF7</accession>
    <name>A0A654DZF7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nuoH</name>
        <name evidence="7" type="ORF">MARINOS108_12100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="372" mass="41510" checksum="56DAAD85500DE9DF" modified="2020-04-22" version="1">MSVSSFNLAANIFRKTDVLGLMITFLFFLPFLLGFVVVGVYGERKIAAFVQNRLGPMEVGPKGLFQTVADLLKMLQKEDIRPKAADKALFLFAPILIFASIFGGFAALPLTTEAFPPAFSVGVFYLLAIVSIDVLGILMAGWGSNNKYSLYGAMRSAAQIVSYEIPLGLSVLAVVMYAQTMDLQSITQQQGILGEAPRYFLGISSLEVTGIGGFLSWNVFTMPFMWVVFLIFFISGLAESNRVPFDLPEAESELIGGYHTEYSGFRWGIFMLSEYAMMLLVSFLAAILFFGGWNTPLPNMGVLKLADWTTGPVWGAFWLVSKGTFFIFLQMMIRWTYPRLRVDQLMSLSWKYLTPAAILLLFVVGIWKLWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF8</accession>
    <name>A0A654DZF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="28601" checksum="88DB51F951FC5CE6" modified="2020-04-22" version="1">MKITLVIIGFLLLVFLIQLGVAPAGVARQWQEKLEAKDSLYMQKYDPAYELSEVSSLARKKAFLEAQLQLAEEDSIHLIVNLRDSSIHLAIHGVIIHTSKLPSIENDALLKSIPNRLYLGLFSDPVPIISIHSTILKEPIVERQAPKDPVEAALNAYEPDTLIQNPAYIRLRLAHGIDLILEQHPNPTFAEQWTRYRFRQENRPTVTSRLQRMVSLKGQEYTPDIRLKLPANDIRALYRALPAQPKVVLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ3</accession>
    <name>A0A654DZQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024819879" evidence="1">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="292" mass="31847" checksum="4D7ACC08F02CF6AD" modified="2020-04-22" version="1">MNMMSKITKLTLLAFLCAYGTAMAQINTPQASPAGSVSSVVGLTEVSIDYFRPKVKDRKIFGEGSEFLQPYGQLWRTGANSGSKLTLSTEATIAGTKVPAGEYLIFTIPGKDEWSFMLYSDLSLGGNVNGYDAKNEVVKATVKAEKLSSPVEALTFNISDISEDNTKANIELTWSDVSVKVPLEVSFVEQVMADIEAKTKVNPSNYVQAAGFYLSQNKNLPQALEWMNTYLAIGDNGQQFWHVHTKARIQAAMGNKKEAIATAQKSLDIAKASPNGDFGYVKRNQDFIASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT5</accession>
    <name>A0A654DZT5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">msrB</name>
        <name evidence="5" type="ORF">MARINOS108_11080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="63"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="20710" checksum="7E721E5609CF6492" modified="2020-04-22" version="1">MFLVKGNKSQISLVRLFMNGLKLLSTVIILGILSQACAQEKTANESGQEKTTESDIIPIKLANSEWKQRLSPEAYYVMREQGTERAFTGAYWDHKKEGTYVCKACDLPLFSSETKFKSGTGWPSFYEPLAKSNVGEEKDSSYGMARTEVHCARCGGHLGHIFPDGPKPTGLRYCINSVSLNFKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY4</accession>
    <name>A0A654DZY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_110091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD15929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="13446" checksum="1B5D10558D7CD3C6" modified="2020-04-22" version="1">MFELFMMGGPLFMGIITVIFIAALVVSVRSALFIFGGASVASDQLFRQLGYIKSIGLFALVMGVLGQMIGLYSAFAALEQMEGGVSPQLLAGGLKVSSITTLWGLLSYGITLLIYLILSAVARSKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E030</accession>
    <name>A0A654E030_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="510" mass="56155" checksum="5F79DC1F78194F36" modified="2020-04-22" version="1">MQRFKTAVQCLKKAVQRSKKAVQCSKTAVQCSEITVQRFKTTVQRSKMAVQRYKTAVQYFKRTMQRSKKVVQCTYGQQWFDQDRKSARFGRERLTNDHWWLLACCYDQFLKFNNHLNMKKIILTLGLALTVMTVLAQWTDNGGYITTNDKVGIGLNPSAQFQIRAGTSATSYFNGAAIYNNAGNAIRSSLSVTSDDNGRINLYNNSTSLKVLINSYGDSYLNGGSLGIGTNSPNDGLVHIYRNATTGGIGSVNTANAGLRIQDNGSSLYIDGNTLYTSGNMVLGTLNNTTFSVGTNDTERLRIDSNGNVGFGTSSPSNSLVHIYRDATIGGIETPNTSNSGLRIQDNGHNLYIDGNSLFTTGNMFLSTINNTFFSIGTNNSERIRINANGNVGIGTITTGTHRLAVEGSIGAREIKVEANGWSDFVFENDYDLPTLEEVEQHIDENGHLPEIPSEAEVAENGINLGEMDAKLLQKIEELTLYLIEQNKELKTAQTEILELKKEVSALKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E049</accession>
    <name>A0A654E049_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024793054" evidence="1">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="14871" checksum="DC84E93CC174386E" modified="2020-04-22" version="1">MKNYSRILLALVAVFAFTFSNAQDLPKTGAVIRVDADKVQLVPGETFETTLTIVRSKADRKTKFETPVVQEMEGLHASVSATDQADTYLLRLTPTTLLEGTHLLIIKGSGPNRRYLTSKALSVKMTDGESLASVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N7</accession>
    <name>A0A654E0N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="29600" checksum="85BB45633096D683" modified="2020-04-22" version="1">MKLSTIIITYNEAQNIERCIRSVQKVSDEVVILDSFSTDRTPDICRNLGVRFEQKAYLNQIDQKNHVLTLAQYDHVLSLDGDEALSEELAGSILHEKDLGFPNQAYLLNRLSFYCGKWIRHGDWYPDWKVRLWNKHEAHWGGSNPHDRVFPRKGIKPKKLQGDLLHFTFSTLQEHQRQVKKYAEISATTYFGSNRKFSLARMILSPITSFVKSYLFRGGFLDGRHGWQIIRLAMMEKYLKYKKLHQLQKMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E115</accession>
    <name>A0A654E115_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">uvrA</name>
        <name evidence="16" type="ORF">MARINOS108_140093</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="617"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="652"/>
            <end position="659"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD17556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="952" mass="106727" checksum="D4F82E6DB3E4249F" modified="2020-04-22" version="1">MSISETEIEQMVDSQEETQQYIEIYGAREHNLKDVNLNIPRNKLVVITGISGSGKSSLAFDTIYAEGQRRYMESFSAYARSFIGNMERPDVDKINGLSPVISIEQKTTSRNPRSTVGTVTEVYDFLRLLFARAGVAYSYVTGKKMIKQTEDQIVDHLLKTYDGQKLIILAPVVKGRKGHYRELFVQIRKMGFTKVRVNGEIQDLVAKMQVDRYKTHDIEIVVDRVIVQSKDEKRIRQSVQAAFKQSDGILMVQDQENNVAHFSKYLMDPESGISYDEPAPNTFSFNSPYGACPTCHGLGLIEEISKDSVIPDPSLSISRGGIAPLGEYRDIWIFKKVEAILKRNKVNLTTPIKDIPEKTMEVLLYGDDIPVAVGSVKYPGTDWHTKFEGIIKFLEKQRETGSDKIRQWVEDFTDIATCPECSGYRLKKESLHFKIHDKHIGELAEMNINRLSDWFEGIEARLDDRQNIIAGEILKELRKRIGFLLDVGLDYLSLNRSLKTLSGGEAQRIRLATQIGTQLVNVLYILDEPSIGLHQRDNVKLIQALKDLRDLGNTVIVVEHDKDMMLASDFVVDIGPGAGRHGGHIMAAQPPAEFIQNKSLTADYLNGNLKIEIPTDRRKGNGNFLELKGATGHNLKNVDLKLPLGTMICVTGVSGSGKSSLIHETLYPILRKHFYKSRTEPLPHQSLKGLDKLDKVIEVDQSPIGRTPRSNPATYTGVFTDIRSLFSELPESKIRGYKPGRFSFNVKGGRCETCQGGGMRVIEMDFLPDVHVLCETCKGKRYNRETLEVRFKGKSISDILDMTVEAAVDFFEFQPKILKKIETLHEVGLGYVSLGQHATTLSGGEAQRVKLATELSKRDTGNTFYILDEPTTGLHFQDIQHLLEVLQKLVGKGNTVLIIEHNMDVIKVSDYLVDLGPEGGEKGGQIVGRGTPEDLAKNEKSHTGKFLKEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E175</accession>
    <name>A0A654E175_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="14161" checksum="319B42E785FBF6EA" modified="2020-04-22" version="1">MEKEIKKAVMLLKSLILHYHGLDDDEKLILEAAAKELDAVEELAWADHFISEDYLSAFERSRDFFFKNLAESSNAEKLKHLKDVWEDNHQKGYVTEMETTAMIKLSKDWGVEKEFLKVIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F3</accession>
    <name>A0A654E1F3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="638"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="745" mass="82605" checksum="008D56FFF54BACC6" modified="2020-04-22" version="1">MINYAAKIAQELSLQPRFVEATTTLLDGGATVPFISRYRKELTGTMDEVEVAAVRDRLAQLRDLDKRREAILKSIEEQEKLTPELKKKIEAAETMAALEDLYLPYKPKRKTKASVAKEKGLEPLAKVLWQQGNVSPEQEAEQYISEEKGVEDVNAALQGARDIMAEWISEDAEARQKIRDLFKAEGMISSRVLKGKEVEGQKYKDYFEWEESLKTIPSHRLLAIRRGEREGILIMDTFVPEESAIDRLSRQFVQGSNAAAEHVATALKDSYKRLIKPSIETEARMESKKAADTEAISVFVDNIKQLLMAAPLGQKAVLALDPGFRTGCKVVCLDRQGKLLEHTAIYPNEPQKDIHTSAAIIGALCQKHSIEAIAIGNGTASRETEQFVKGIGLPASIIVAMVNESGASIYSASEVAREEFKDYDLTVRGAVSIGRRMMDPLAELVKIDAKSIGVGQYQHDVDQNALKHSLDDTVMSCVNGVGVELNTASKQLLTYVSGLGPQLAENIVKHRNENGAFKSREDLKSIPRLGDKAFEQAAGFLRIKGAKNILDESAVHPERYNTVYTMAKDLGCTVEDLVKDQNLRSRIDLKKYVSDDLGLPTLKDILAELAKPGRDPREQFETFAFADHVHEIKDLSVGMKLPGIITNITKFGAFVDVGVHQDGLVHVSHLSDSFVSDPTKAVKLQQKVMVTVLEVDVPRKRISLSMKSDPYGKSAPKQDRKKREEKEPEGDLQAKLAMLKGKFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q5</accession>
    <name>A0A654E1Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_130006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="956"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123308" checksum="05E7A71277A3619C" modified="2020-04-22" version="1">MIKSFLAFLGGEPGEEKPMLLLLGMGFFMGIFLATYQIGSETLFLDILGEPYLDVAFFSAGGAGIISTVLFVYLQKRVNYSSLVVVNLFLIFAFMAVMRAAFEWTSYDGSEGGFQILPFIMFVMIGPITAITLLGFWGIFGRVFDLRASKRIIGGIDTGALTATIIAFFSIPFITQLPFIDSTYDLLFVSAISSFGVLFFTIWIIRDFNVNKATKVEKGDVKPVEVNFFDLIKDPYLRLLSLFLIFSMGASVFVDYTFYSATEIMYPDEQELTNFLSFFSGTVMIMSFLIQSFVNDIIIGRFGLKVALMTMPLILILFTIGGIVAGHIFGYQVKTEEFILFFMFTACAKAFTASLKDALENPAFKLFFLPIDIKIRFDIQTRIEGVVNELATLLAGAAQIALGLLVFFELIHFSYLILGLAGMVVYLSGKLFSQYKVTLQKTLTEQKKALKGEGVRNEQNTINVIRSEVSSKNSDRVISGLRIFEKLEPIQFEFTLLDLLNSRMSKVREYAYKKLDEYLVFEALDIIRKDIKTEGDEAVLKAATACVKNLEAAEAYELNDISIRQLVRSTEAKDRIKGARLLVKSNEDKFLPYLSELLRDINPRVRIAAMTTAGKIRRPEIWPNLVENLHLATYGNSAMSALTHSGEAAFHAIDTSFYKTGQYKATMLRIVQLLGRIGGKSAIDLLWKKIDFPDKKIVSEILLSLSYIGFAARDFQAARIKIAIESEIGDIAWNIKAVLDIPEENEIDMMIRDAFREEDKQNYENIFMLLSMIYDPQNVTLVRENIQDGTTDSITFAVEMLDIFVEEELKPKLLPVMDELKVDDRLAKLQNYYPPEDFESYYDLLLQIINRDYNRVNRYTKALAFYRISNMTGVEVSDDLIANLFNPDHLLLETAAYTIYKLDQSAYHLHTKRLKSGVKKELDKAIVPPVFQGEGEDYHQKLLLIERVLLLKEVPEFKRVSGELITYIAEELDEIRLNEGTTLVDAGESGNTPVYIVVEGNVDVYQNDVLIDQKSRGGLVGHELILDTNKFEYTALTRNRCTLLVLRKEELLDLMSKHIEIIEAYLNILNRVEFEEEEVEIADILLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R5</accession>
    <name>A0A654E1R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized PabA-like protein HI_1170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="71"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="319" mass="36279" checksum="816EEB277232CD14" modified="2020-04-22" version="1">MLEREEAIARMNELGARGIPFFFFTDFLGHRCLIQPLDEINPSVLRFAIDQPAAKDRKPAFHFKKHPLTQAQFHGPFRYVVEQINYGNSYLVNLTFKTTIETNLSLADIYELSRAKYKLLYQDQFVVFSPETFVKIADGRIYSYPMKGTIDASLPNAEAQILNDPKETAEHVTIVDLIRNDLSQIASEVQVSRFRFISEVKTHEKKLLQVSSEITGKLPADYHQTLGSMFFQLLPAGSISGAPKKETVHIIETAETYDRGFYTGVCGLFDGKDLDTGVMIRFIEKEGDQLYYKSGGGITSFSDEAREYQEIIDKIYLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W3</accession>
    <name>A0A654E1W3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mltG</name>
        <name evidence="8" type="ORF">MARINOS108_20175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="344" mass="39274" checksum="C31BABF72D99D777" modified="2020-04-22" version="1">MKKKNFIAAFMIVFAVMLSSFAFYGYQVLYTPNILVDQEDRMFAIEDGTTFKELQNKLYDQRIVNDLVSFSFLAKVKGFDREIKPGMYLFKKDMSNTEAINMLRAGIQTPVKLTFNNARKIDELASKLTFPLQIDSADIAPLLMSDSVAQAYGLNANTFICMFLPNTYEVYWTASPKDILDRMKKEYDRYWNDTRIAQAAALGLTPTEASTLASIVDAETNKMDEAATIAGVYLNRLKKGYKLQADPTLVFAIGDFSIRRILNKDKDFESPYNTYKYRGLPPGPINMPSIAALEAVLNAEEHRYLYFCAKDDFSGYHAFAKTLEEHNVNAARFQRALNMERIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y6</accession>
    <name>A0A654E1Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster repair di-iron protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ric</name>
        <name evidence="5" type="ORF">MARINOS108_20143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019903">
        <property type="entry name" value="RIC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36438">
        <property type="entry name" value="PTHR36438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04405">
        <property type="entry name" value="ScdA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03652">
        <property type="entry name" value="FeS_repair_RIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="78"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="242" mass="27855" checksum="6A0768967B096581" modified="2020-04-22" version="1">MKNLAKSKVGVIVASNFRTSRVFSSHHIDFCCSGGISLEEACTRNNVDLDRVLEELEATFQTPDTMNYQELDLDKLIDTIVSMHHSYVWATVPALRAYLEKLCTVHGDRHPELHSVNDLFAKGSQALLDHMTKEEQILFPYIKAMVQAKAKEFPLSKPHFGDIENPIQMMEQEHEEEGFRFRQIAELTGGYECPPDGCQTYKVAYAMLKEFEEDLHKHIHLENNILFPEARKLFREFSFSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E206</accession>
    <name>A0A654E206_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32709" checksum="77AB3F26DC565825" modified="2020-04-22" version="1">MNARLITIILMAVSLFSCNEEDGNDPNIPDIEEYTTDISFRLKGKEYFTGKLHMPEVRDGISAFMYLYNQGVMYFYFPQAPLYTVDDNKEVIAGVLGFYASQGEDDCCISEGETLDYTNGRLNLAISLFEENGEYERGLTFFYADGTEELAYQETPFNTYAAFTNGQPADINMSFNTLKPNRIAATLRGTVESFLNNELFTEEVNIQFAIEGVLPLFMDLRSLPDGSGAVCANLNYNGPTEGQAKQWCQYAQFLDCNGLITERDVQCQILLDYGATCPYCKAYPEKLQLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E246</accession>
    <name>A0A654E246_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="33747" checksum="F9A119CD1C5A655D" modified="2020-04-22" version="1">MWKPSINHSFEPMHQNELRNSEKKPSRWLFHATIIGLAMMASCKPADKTGFADDAGGEPTEIVVYNNPPSEGFDIEGSTPHAIVMADQIMNAMGGREKWDQTNVIFWNFLGVRTLLWDKANNKVRIDIPSSKMVIALDMNDMTGNVWKDQVKYTQEDSVSKYLEQGRKMWINDSYWLVMPFKLKDSGVTLTYVGEDTTRQGNRADVLRLTFKNVGVTPDNAYDVWVDFDTRLIEQWAYYKEATQEEPNFVLPWTDYQDYNGLLLSGERGDRDLTNIKVLKSVPKGAFESPEPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E287</accession>
    <name>A0A654E287_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein SprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026377">
        <property type="entry name" value="Cell_surface_SprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025684">
        <property type="entry name" value="SprA_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14349">
        <property type="entry name" value="SprA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04189">
        <property type="entry name" value="surface_SprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprA_N" evidence="2">
        <location>
            <begin position="108"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="SprA_N" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2379" mass="268578" checksum="091D1D4FF63D9D8F" modified="2020-04-22" version="1">MVSVISLCLWVSLPEATFVSASSSVLIFQDTSRQDTVRTDTIPPYTPTKAPTFQPAYRFGDPFSNRISPSPLLLADPSSIDLEVDFDSTVNYSVSERIGDVNFRPVTTMTFEEYDRYNDKQITKEYFQERSAGLDGESAISGRSLIPRLYISPVFDRLFGGSYVDIQPNGFVNLDFGGRFQRVDNPAIPIRQQRNGGFNFDQQISLNLVGKIGEKLAVTANFDNNNTFDFQNNLKVEYTGYEEDIVKKIEIGNVSMPVSNSLMTGAQSLFGLKTQLQFGKLYLTGVVSRQQGKSDVITVESGFQGKEFEVRASNYDENRHFFLGHFFRENYEKWLKTLPQITSGVNVNRVEVYVINRNNDTKSTREVLGLMDLGEGQRIYQKGNPKVGSGDGNVPTDNGANDLFQSITNTPNFRSSDQVTNTLENDFGFVNSTDFVKVGTARRLDQDEFVINTRLGYITLLRKLQNDEMLGVSYTYSYDGKTYRVGELTEDYSGLADDQVILLKMLRPNKINTKVPTWDLMMKNIYNLNASQIEREGFTLRVHYRDDATGIDNPSLHEGRFTKDQPLVELLGLDQLNQNNDRQRDGNFDFIDGVTIDVRNGNIIFPVLEPFGATLESKFASDEVSLKEKYVYDTLYHTTKADAEQVASKNKFFILGKFNAGSSNEIALPGINIAENSVIVTAGNTPLTEGLDYTVDYNLGRVRILNEGILSSGKTINIAYEKADLFNFQSRWLYGARADYKFSENFNIGATILQLNEQPGGVSRYTIGDEPTRNTKYGFDLNFQDEVPFLTKFMDFLPLVSTKAPSSITVNAEFAQMIPGTSNLVDGKGTSYIDDFESAVTPINLGGWAGWDLAATPKTTDRKFDKSTEAGSTLGLNYKRAKIAWYTVDQSVFYRTGGPNKPTNITDEDLQNHYVRPVLPQEIFRQQSRNLIVTPETLFDIAYFPSERGQYNYNPNLTRDGLLPDPKSNYGGITRAITNEVDFDKTNIEYLEFWMLDPFIDTPRGRVMDGKFNTNNTTGGDLVFNLGSVSEDVVPDGRHAFESGLPANGDPAQTIANEWGRVPSEPFLTNYFENSGSARANQDIGLEGLKDEEELTYFADFINRVSVSTEVLDQLKSDPSGDNFQYFLGSDLDNQDLKILERYKNYNGLDGNSPVNSGNSITRASTTTPDNEDLNQDNTISDLEEYYEYRLSLKPGELEVGKNHIVDAVTDDSREATWYLFRIPIRNPDRVYGGISGFKTVRYLRMYATNFQQPVVFRMTKLQLVGSQWRKYQEALNEPGLNEIPETSYSDFNVSVVNIEENSMGGENKSPYVVPPGINRDRDNTTIINRQLNEQSLQVCVDNLEDKDARAVYKNVTFDLINYGRLQMFLHAEAHNGEMLLDNEINAFIRFGTDFTEHYYEIEVPMKVTPTGLDANGGDNIARLVWPLENEIDLSIDELLGIKSERNRNDFDENVPYSTPSNNGQYKLTIKGRPDISSVQVLMLGVRNPESDDRATKSVCLWANELRVTDFDTKKGWAANARVSTKLADVATVSASTRYTSIGFGNIQQTIQQRTRNETIQYDISANVNVDKFLLPEKTGLKVPMFVSYEKSRITPQFDPLDPDVPLEASLATMDSDEERERYRRIVEDRTERRSINFTNVHKEKVNPEANSHFFDVENLSFSYAYSDVMTSNVNTETYLQKKVSGGVAYNYAPRTISLEPFAKMEALKSPYLKLIKDVNLSLLPSSLAFRADLDRSFRMTQLYNDKLEVSPDLAPYYERLFTFNRNYNLRWNLFKSLNLDYTARVNAVIDEPDGIIEGDITTQEERQYVWEEIKDLGRMKNFAQDISATYKTPLDKLPLTDWLSADIKYATGYTWTAGSQVEHDSLFFGNTIENRREQGLSGKVDLVKLYNKVTFLKEINSPPRAKAGEEAPGFNIGKSFLRTVMSLRNINVTYSVREGTTLSGYSPRAFLMGMDSGFNAPGWGFILGSQDPDIRFRAADNDWLNKNPDLSSPFMQTYTTDLGLRASIEPAKDLKIQLDAKRTNNATYEELFRYSDEQTENNGFSSLTPSRKGSYNISFMSISTAFDKRGPGNTSEAFDTFAENIEKIRIRQTALNNEIGFYDSLSQDVLIPAFISAYSGQSSSEVSLSPFPKIPLPGWRVDYNGLSKIPVLAELFSSITLTHGYRSLYNVNDYNFDNDTYGDLLGNDLSVTLNSNVLDYPQATDTTGTGRYAPVYILNQVTISEQFAPLIGINFRTKSNISTRLEYKKDRNLSLSLANAQITETTSNDVTLDFGYTKEEFKLPFKIQGRTITLDNAVTMRISMTIRDAETIQRKLEGENKVTTGNTNFQLRPSFTYKLNDQLDLTMYFERSVTEPKVSSFKTATTAFGTQLRFSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D3</accession>
    <name>A0A654E2D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4920" checksum="BCD3ED8C4DC5532E" modified="2020-04-22" version="1">MLNHSWILQREASGIGHLMDLGFHFIVWFLILYKDAIHPSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K6</accession>
    <name>A0A654E2K6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAA_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22906" checksum="8C7B80E2C2026A49" modified="2020-04-22" version="1">MKIICIGRNYADHITELGNERPETPVIFMKPDTAILRNNDAFYYPDFSKDIHYECELLIRINKEGKSVEPRFAHKYYDQIGLGIDFTARDLQAKAKEKGLPWEMAKGFNGSAPTSPFISKEGFDLTNTQFQLELNGQVVQDANTSLMLWPVDELIAYVSKYFTLKKGDILFTGTPKGVGPVKIGDRLVGKLAGRQMFDFEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V4</accession>
    <name>A0A654E2V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF559" evidence="2">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="17136" checksum="82D97BD663703AFC" modified="2020-04-22" version="1">MRRKIIPYHPKLKELARQLRNNSTKSEIRLWQCLKGKQMMGYDFHRQKPLLEYIADFYCYELELVIELDGYTHNFEEVVEKDEIKQKALEEVGLTVMRFADVEVMHDINNVLRAIENYILDREKHTPDPSQEGRNGDQHQSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X8</accession>
    <name>A0A654E2X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative enzyme</fullName>
            <ecNumber evidence="4">1.13.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="386" mass="44419" checksum="5AC934236D69B4FE" modified="2020-04-22" version="1">MTFYHRLGEIPPKRHTQFRQPDGSLYAEELVSSRGFSGIYSNLYHITPPTRIKAVKQSIPYDTKIVKEHGLKQTHLKTSGVRETGEDYLGAREVVLMNSDVKMALCNPRSRSMDYYYKNAEADEVVFIHDGNGYLLSQFGKLRVKQGDYVVIPRTTIYKFEWDEGPLRLLVIESASPVETVKRYRNELGQLMEHSPYCERDIRPPSELITEKERGSFLMKIKKDGMLHQYEYDQSPFDLVGWDGYLFPYALSIHDFEPITGRIHQPPPAHQTFQSQGYVICSFVPRLFDYHPLAIPAPYNHSNIDSDEVLYYVDGDFMSRKGIDRGSFTLHPGGLPHGPHPGTVEKSIGAKETKELAVMLDTFRPLYVTEEGMKYVDEKYPMSWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E355</accession>
    <name>A0A654E355_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="21017" checksum="285B8067D38B6B85" modified="2020-04-22" version="1">MTREEELALIEASKKEPGAFRPLYQKYYGQILGYVAKKIGNTTLAEEITSDVFFKALTKINLFRPSGHSISPWLYKIALNEIRMHFRKTQKENYLFDRKTLVEPLHLFELPGDHEVLERLEKILLQQKEKDLTLLELRFYQGLKFEEVGQVLGMSHENAKKRTYRLLEKLRTELMEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E369</accession>
    <name>A0A654E369_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein OmpA-like peptidoglycan-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024993841" evidence="3">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="113"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="25801" checksum="89D754AEA3EBA1EA" modified="2020-04-22" version="1">MYRTLLSLILITAALISQGQAIDKYVRFNGKVLSQKDSSGISASIYYEKLPYYDDMGTAKSGPQGNYEFYLINGDKYNFRITLNGFLELTRELTVTNANGDGSMNFDFYLEPEEEPELITLNNLIFARGSDVITESSFEELDNLVEYLDSRPSLIIQLEGHTDFAGNPEANMSLSEARVVAVKEYLVSKGVKKNRVLTKAFGGSQPLYTERTDEAKTKNRRVEVRVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K7</accession>
    <name>A0A654E3K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="14535" checksum="35FB87BFBDA4847B" modified="2020-04-22" version="1">MKNNTALFVMISLLTITSLYGQYQEPTKSAQYEAGLLLQKFSKQYFAGTALVGGGYLFTTLALSGNQPNEPMVIAGSLMALCGAVVMIASHGQIGKAGEKLMISSQSLSYTDQKVNSLGIRWKIGSRKQHGLLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R3</accession>
    <name>A0A654E3R3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="25988" checksum="2032B27ACDC0B8A3" modified="2020-04-22" version="1">MPISNANFRFLNELSLHKNREWFAEHKHEYEVFHEEVKNLAKDVEVLMNEHDLLAGGRVYRIYRDVRFSKDKTPFKDYWAGSFRRSTALLRGGYYYEIAPGRSFVAGGFFGPNPSDLLHIRKQISQEPEPLWEVLNQREFKQYFGDLKGDAVKTSPKGFSIDDPAIMLIRQKQFVIEHYFTDEEVLSPDFPETINSAFRAMRPFLDYMSEILTTDLNGESMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R7</accession>
    <name>A0A654E3R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="93"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="782"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="876" mass="99490" checksum="4E3B2F47B89AAD2F" modified="2020-04-22" version="1">MQMTPPKRALKFLRWFCREEFLEEIEGDLIELFEKRLEVSPQSANRKFLWDVIRAFRPINIKSFTINNWTMNALQNYTKVYFRRFRKETTHYLVNTLGLALGFAVLFFILMYVYDEEHLDRYHAKADRIYRVLEKRTGEDGEVQHFSATSNMLADGLKAEFPEIEETAKMISLGSGGLQYGETLFNDRNYVFATKSLFNILDFNILAGDPFQDFNGGVGVVLNETTARKLFRDEDPIGKIVTMPGRMSSVEVVAVYEDLPATSTYQFNTVYVADFAQFPAAYGDWLTSWNSRGMTTWALFKAGSRPESVLAKKEGFMKKYYNDEIRPHHDFYFQPIAEMHLGSGHLDTFGSDAVVSIPYSQRQFVSIIFLIGLFVITIAALNYINLSSVQALKRTLEAGIRKVNGATIGQLRFQLFVETFLTLLIAYVLSVVLLIVFHSKFLELSDKVIPLSRFFSLDLLGYHAVAFGVIWVLSSLIPAVYYSKLNHSLILTRNVFVGKGDLLRKLFVVVQYGISLCLIIGSIVLYRQLHYVQTKDLGFRNDKLVTLDINSGTARQRFKSIIAGLKEHASVVNATTSSRVPGEWKYIPSVELSQVQNENPVVATHYAADENWLDTYQMTLKTGSNFSGVAGSDTLKVILNEKAVELLGLEDPIGASVWIAEDTLSKMQVIGVVKDFHFQSLHVPLGPVVITSWNNPVLGIDYFTIRYQENLPEVLAHIEEVQKRYDPETPAEINFLDERWERYYQADQSRSYLILIATVISIIISAFGLFGLVNFTVERKTKEVGIRKVLGASIPNILQIILRDYVALLLISLFVAAPVAWWTLNGWLQDFAYRIELSVGVFTIAFAAVLVISFVTVIARVYRLAKSNPVNSLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S1</accession>
    <name>A0A654E3S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="527"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="597" mass="63922" checksum="6759DBE5FA648903" modified="2020-04-22" version="1">MKAKLIIVITLMIIGTGLRAQDAIHDLDFDVQKSSISAVDIDADGDRDILIIGENPNGKFAQLFRNNGEMSFEKVASPFAPSAITSVTFGDVNGDGQLDALQSGFADSVIVNLYTTNESGDLALDDFYSSLAHIAPSSAIADLNNDGHADILIFGNHNIEDQRPKIYFGDGTGGFTSESPFDTYKFIDPKVSTVDVDTDGDLDLWVMAGYEEGIDARFARLFINDGGTFTETDPGIIAKGPGSSDWGDYDGDGDLDLLIGGWGYVNSGEDNDMIYRIYKNTGGTFTEAAVFQPFGAFSPSDASRFADWDNDGDLDVILTGWNPDEGGQRTAFFINTSGTFAAADYNATLPGISESAVAISDLDDDGDLDLIINGYSGNEWNGEGSAYNRNVALVIENTTAGTNAAPAPPANLSAKANGKAVTFSWDEATDDSTPAASLSYNLFLVDSDGNYFFYPVADTTSGKLMVQEKGNMQLNNAWTVKGLPYGEYRWGVQAIDHSFAGSTFAKDNFSHLEGGPLATSLESDALIYPNPNQGQIQVRVNNQIRQLSILTMDGKLVRSLNVEAGAKSVQIPMAAGIYLVRALRADGHSTSDKVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T8</accession>
    <name>A0A654E3T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmotically inducible protein OsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15610" checksum="7A65E5C6F68D5137" modified="2020-04-22" version="1">MSTMKIKMGFKSDQEYFAVNESGNRIEIDMLAAEDKKAMSPMQLLLAGVVSCAAVDLVAMVKKRRKTLVAFSGEIDGTRREEYPKKFTDIHVKYTFTSPDLQEEEAEKLVNLAVEKYCSVAATINESTKITHSLEILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E450</accession>
    <name>A0A654E450_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RSAM/selenodomain-associated transferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02522">
        <property type="entry name" value="GT_2_like_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026461">
        <property type="entry name" value="Trfase_2_rSAM/seldom_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04283">
        <property type="entry name" value="glyco_like_mftF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="29303" checksum="90C4A6922EEC6535" modified="2020-04-22" version="1">MSYPLESIKFRFQITAAIVLNISIIIPTLNEVANIRRLCAFLCNHQANDHFEIIVVDGGSTDGTIDSISDLRKVTILNSHIASRAVQMNLGAANASFDVLYFVHADVILPYTFYADLQQALVDYQVGSYRYRFDSTKWLLRINGYFTRFSMLWCRGGDQTLFIQRSLFDQLGGFDEYFSVMEDFDLIRRAKKLTHFYIIPKEVIVSARKYEHNHYLRVQWANMQAFRMYRNGVKPEVIRHFYKESLKLATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C8</accession>
    <name>A0A654E4C8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">metXA</name>
        <name evidence="5" type="ORF">MARINOS108_50093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="59"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="37534" checksum="BFBE5A0B041266F8" modified="2020-04-22" version="1">MQTIKLMPNTIEQIQPKSAILKVEEPFILECGDTLRNVRISYTTYGTLNSEKTNVAWVFHALTANGNPAEWWPELVGPGKAIDPEDKFVVCANMLGSCYGTTGPKNYNFPLVTIRDMVNAHKLLKAHLGIETIHLGIGGSMGGQQLLEWAVEEPTLFDHIVPLATNAFHSPWGIAFNEAQRMALENIDSAKGLEAARAIAMLSYRHYNTYNKTQRDIDQRWDDFSASSYQRYQGEKLRKRFSVESYYYLSKAMDSHHVGRHFGSSETALKRIRSKALVIGIDTDILFPPEEQQYIAGLIPDAKFRLVTSAFGHDGFLTESEQISELIRDFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K8</accession>
    <name>A0A654E4K8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15 16">Protoporphyrinogen IX oxidase</fullName>
            <shortName evidence="15">PPO</shortName>
            <ecNumber evidence="15 16">1.3.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MARINOS108_120432</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:62000"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 16">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cell membrane</location>
            <topology evidence="3 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15 16">Belongs to the HemJ family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="15 16"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070818">
        <property type="term" value="F:protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02239">
        <property type="entry name" value="HemJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005265">
        <property type="entry name" value="HemJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40255">
        <property type="entry name" value="PTHR40255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03653">
        <property type="entry name" value="UPF0093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004638">
        <property type="entry name" value="UCP004638"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="13 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD16954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="21271" checksum="3E4AB499E28C2A95" modified="2020-04-22" version="1">MDYLNVKALHIIFIVTWFAGLFYIVRLFIYQTEAQLKPEPEKTILSEQLAIMARRLWLGITWPSAILTLIFGSWLLILQPAWLQQSFMHIKLTFVFFLFLYHFSCHYLYKKLQKGETKFTSNQLRIWNEVATLFLVAIVFLIVVKNQISWIWGTIGIFTFALALMLAIKLYKRIREQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X0</accession>
    <name>A0A654E4X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025028241" evidence="1">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18913" checksum="636EB582AFB834F9" modified="2020-04-22" version="1">MRRGYFIKLIIAVFFLVAISSTDTRAQLVSESDISFDILKWHFHHYPKSETKQWLDSGEDTYTVSFVFESMDVSVVYDSRGKRIEERVDVSNSMPVSLVYHLDDQYEKYKVMRFEKVTKFKQDNSVGYEMKIRSKEKGDEQLYFDQNMVPIDFNLISKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X7</accession>
    <name>A0A654E4X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="395" mass="44935" checksum="CB293BCDF66F6538" modified="2020-04-22" version="1">MGCASCSTAGSEDGVALGCNNNGGCSTGGCNKMNVFDWLSNMEDPIVSDFNIVEVRFKNGRKEFFTNNNHLNLTTGDAVVVDVPNGHHIGHVSLQGELVRLQMKKRSVEENEEIKNIYRIASQRDIDKYREVKKREMPTLYRTRQIIEDLKIGMKLTDVEYQADNTKATFYYSAEERVDFRELIKLLAGEFKIRVEMRQISLRQEAGRLGGIGSCGRELCCSTWLGDFKSVSTQAARYQNLSLNPSKLSGQCGRLKCCLNYELDTYMEALKDIPEVEKPLETAKGRAKLQKTDIFRKIMWFGYDDENTWYPLDVKRVNEILELNKAGKKPVTLAEDVVEVVKDDVGLNSDLVAMDRKFSKGDPKSKGKNKKRKFNKNKNKNKNRKNRPNNQNKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y6</accession>
    <name>A0A654E4Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase-like metal-dependent hydrolase (Beta-lactamase superfamily II)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24131" checksum="F19564A3446AC654" modified="2020-04-22" version="1">MKIKSFVFNPFYENTYVLWDDRMEGVIIDPGCYESYEKEELTDFIKKTGILIKAIVNTHCHIDHVLGNYDMKLAFGCPLWLPEGELEIFRAVKAYAPQWGIHQYSESEPDRLLKEEDHIEFGETTLECISVPGHSPGHLVFYHSGEKKLIGGDVLFRESIGRTDLPGGNHAQLLKNIQTKVYTLPEETEVFPGHGPSTTVGYEKANNPFIKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E506</accession>
    <name>A0A654E506_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21780" checksum="C9EB5D9A1D66B49B" modified="2020-04-22" version="1">MNPSSKQIVHISDDQVFESLFRTHYDELVHFALSYISNEDDAEEIVQQLFVTLWSQTTIDINTSVKSYLMGSVRNRCLNHLRHEKVKASHATHHQITHPNASNIDFLELEELKEAIEAALNKLPTKCRQIFNLSRYEGKKYQEIADHLHLSIKTVENQMSKALKSLRNELKDFLILIFLWMVNGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E577</accession>
    <name>A0A654E577_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024813905" evidence="1">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="326" mass="37120" checksum="DA3AAA1A61A1CB9E" modified="2020-04-22" version="1">MRKILRVILNLFLATSCLMGYGQMVPSEFEQITYLVTFGQESNPGWGDDDFSQVFFFIVPETFTKPVYIRVYDPEVGGQLDEKNGEWNSRTKFSVYGGQGTHSDKDAKQINPVGNYKSGSMLATKTFGNESRYDEDWYSFGPFNPLEGEDAPELGGRVFKVVTEGISGDDGNLYKYFLSTQPYENKEVEGANAFTYEYSFRLPEAKGSVAHLYPFIDKRVVSITQNNFDFDNEGSVLIYSISKNRHRAVASANKKWGRSMHFIDDEEKNTTVDLQIVKGRTSRNDMVCYITNQYEEAIAFFSVPVGGPPKFKYKVDVRYKSEEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5J9</accession>
    <name>A0A654E5J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13623" checksum="2B9671F2744BAA5E" modified="2020-04-22" version="1">MQVYRDVRKLLIPFFIVVLTSCQKETVQVNCDVDYTLVAQDQTYWICGGNYQFVSSDERDTLRIQYNDILRDFFVNEGIQLEDFPLEVSLSFTELPADHTCREWLKQLTCITRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5K2</accession>
    <name>A0A654E5K2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="19783" checksum="A511AABC1E47408B" modified="2020-04-22" version="1">MRKLILYIAASLDGYIAKPNDDLSFLNLVQIEGEDYGYTDFVSSVDTVIVGRKTYDWVIGQGYDFPHADKESYIITRQERPREGNLTFYTGNLKTLVTDLKKKEGKNIFCDGGAEIVHLLLQEKLIDELILSIVPVIVGAGTPLFKTGRPEQLLELKKAKNFESGLVQLHYQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5L2</accession>
    <name>A0A654E5L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024957680" evidence="1">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22313" checksum="0F6FB7EAFEF0B78E" modified="2020-04-22" version="1">MRYTLFFSALIWSSLLSAQPSHHEVTISSGRFILQGTTNLNTFECTLSQALPCKPIVVKTTSEARQIRFEGLELKYPVSEFDCGLEAMSQDLRKTLKSDAYPYLLLRINDIQIKNESQEVAKLTVVSSVTITLAGKSHDALVENGLVINHSEGALTLAGTQHLSMHDFDLEAPTKFFGMVKVNDELNVSFELRMEVKSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Q6</accession>
    <name>A0A654E5Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory ArsR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14951" checksum="4986776DBB7C2454" modified="2020-04-22" version="1">MRLKNFSLNYGTQIFKAFGDEARVRIIHLLFKNDELAVSDLEAILDYTQTKTSRHIGYLKNSGLVNATKKDQWVFYSIKDEVYDMVSQIFDFLNKDLQLQRDQEVYNTMNSNRELAINKLAAKDYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5T1</accession>
    <name>A0A654E5T1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_20994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD20000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="16426" checksum="A4EAAC5D02BB2838" modified="2020-04-22" version="1">MIYVSRKEHFNAAHKLYNPNWTRERNVEVFGPCANDNWHGHNFELIVTVKGMPDPETGFVVDLKKLSTLVRTDITDKVDHKNLNLDVDFMLGKLASCENLVIEFWKILAPKVKRLGSDCTLHSLKLYETPRNYVEYFGETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5U3</accession>
    <name>A0A654E5U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="17842" checksum="3767D589F6A1A3CE" modified="2020-04-22" version="1">MKILAFFASMLLIWVASYGQITQEELMKMLNGEADKDYIGTVTLGLLQGGGSLIGGDLEFLIENKLGLQVGAGLIGYGAAINYHPKGGIRSSFLSLTYWHQGFKEYYTQSLLGPSYVFRGKKWFTAQIGLGFQLEEGPGAKQISTDLPPTQLIYSIGGYFPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5W4</accession>
    <name>A0A654E5W4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="32"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="608" mass="68195" checksum="F7A6BD898E012EC1" modified="2020-04-22" version="1">MKNYLLVSILFLGHLTQAQSELDWWNDAVFYEVFLRSFYDSDGDGVGDFKGLTEKLDYLNDGDPNTDTDLGITGIWLMPINPSPSYHGYDVTDYSGINPDYGTMEDFKAFLAAAHARGIKVIIDYVMNHSSAQHQWFVDSKSSASAEKRDWYRWSDTKPGYSGPWGQNVWHSSGTGYYYGIFWDQMPDLNYENADLKAAMFDHAAYWIDEIGIDGFRLDAVKYIYENGSQLEDLEATHTFFKDLSSHIKSFNPDAITVGEAWTSTSKVVPYVTDERIDFCFEFDLATSIINAARSGSISNLTDQVTNVINAYPWYQFSTFLTNHDQNRIMNELSSDIGKSKIAASIYLTLPGVPFLYYGEEVGMLGAKPDENIRRPMQWTGGRNAGFTTAGSAWNAPSSNYADNNVDKMEDDPSSLLNHYKKLIHTRNEYAALRTGDFITLDASLGGVLTYLRQLDDERVVIAINTTSSNKRFDIDFSSYASASDLPPFDHIGGESLLSVSSEGDLKGLFLSPYQTMILTFDREATVLNASSYGQFEVVPNPAHDLIRINTGTKNLVQHYQLLALNGAVVQSGVFKNEIPVEKVDNGLYLLKITMGNITHQQKIIIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E600</accession>
    <name>A0A654E600_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative periplasmic trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">treA</name>
        <name evidence="5" type="ORF">MARINOS108_60152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024924950" evidence="4">
        <location>
            <begin position="25"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="533" mass="60272" checksum="C9A2CBD9F537940A" modified="2020-04-22" version="1">MTTLKSLKIAGLVVLLFFSCTPQKQTEAADETADFYEPWESLGPLFHDVQMAGVFPDSKTFVDCTPKSDPATIASDYLARKDDPDFDLKAFVSANFIPPSEPEIVASREESLKMHLENHWKNLTRKASESDEISTLIPLPGEYVVPGGRFREIYYWDSYFTLIGLGASGRTDLVEAMVDNFAYLIDTVGFIPNGNRTYYLGRSQPPFFASMVNLYAQLTSVEEATIYLPAVQKEYDFWMQGSEYLSPDLPAVNRVVRLSDGTILNRYWDFLDFPRPESHKEDYELAEGLSDQEQKKLYRNLRAGAESGWDYSTRWFQDKADFGSIRTTDMLPVDLNSLMFAVETTLANLYAADGKVQQSDFYSAQADQRKAAIQRLFWDADKGAFTDYIWTENRLSDQLTLAGAYPLYFIVASAQQADEQARVLESDFLLPGGVVTTTIESGQQWDYPNGWAPLQWMTIKGLEHYDKMDLATEIKTRWLRVNDKVYQNTGKMMEKYNVADTTLIAGGGEYPTQDGFGWSNGVALGLMSDNVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E611</accession>
    <name>A0A654E611_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="642" mass="72599" checksum="8C3739DCBBA0A9F4" modified="2020-04-22" version="1">MKTLNINSVIDPSLLDKGIEIRLKNGEILTQQFAKANDFYLMKSGRVRFFLSMDDSGGEIEVGESDTKLTPIGWSGFNSPGRYATTVKVDSLSATFIKWNHEELREILEANPELGTAFLRDICGRARDLIKIAVKILNAKAPSVLPSLPESSNGFTITAPSPEEDLVKFLRKSAFFEAFDEVPLEFLSQNVERRMYAANEIIYTQDKKSDGLFILGMGKVRFSYHSENQANVSFTQITTPGFVLSWASSVFKANIINAHAVQDTLVYFVPQTSMDRIIKLNPTFSPQYFKRLLWLISHQLQAIRARIIASRLNHEVVAISNLIDQNSARLTLTSPLHKIPHLLDNKLTVTDAIDTLENLKEHGTSLEKTVALSSLDILEGIRKEQQFYKGLVNVYNSVVGAPKDLPAEQVRKISATAYMKIFDHQDHIIKGQENLPEKSGNIFIYNHLRNHTYNTLPNQFQITLDSHFISSMVLMKKYGDPGLRIVRVGLSKEFAHQEYYQRLGHIDVFTEDSGTKPKKLKKQVRQMFYNEAGAHLAKGGNLIISPEGNSYSTEESPGPFKSGAFNLALSMKKEPWIVPVAMANFEKRARNNCFSCLILPPFKVSDYISDPESKTEMKQFLSEYQETYRAYVERALEQSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E630</accession>
    <name>A0A654E630_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetyl-L-homoserine sulfhydrylase</fullName>
            <ecNumber evidence="5">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metY</name>
        <name evidence="5" type="ORF">MARINOS108_50092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="441" mass="47860" checksum="498A9D216B9EAE74" modified="2020-04-22" version="1">MSALKFETLQLHAGQEIDPTTGSRAVPIYQTTSFGFKNSEHGANLFALKEFGNIYSRIMNPTNDVFEKRIAALEGGVAALAVGSGQAAQFIALSNILESGDNFVSSSFLYGGTYNQFKVAFKRLGIKVKFAESDQAEEFEKLIDEKTKAIYLETIGNPGFNVPDFEAIAAVAKANNIPLIVDNTFGAGGYLFRPLEHGASVVTASATKWIGGHGTSIGGVIIDGGNFNWGNGKFPQFTEPSEGYHGLVFWDVFGEGNPLGLPNIAFAIRARVEGLRDFGPALSPFNSFLLLQGLETLSLRVQRTVDNALELAQWLEQHPLVETVNYPGLKSSSYHELAKKYLKNGFGGVLSFTLKGEKELATQLVDNLELVSHLANVGDAKTLIIQPAATTHQQLSNEEQLNAGVLPNLLRVSLGIEHIDDIKADFQQAFEKIYADNQVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E741</accession>
    <name>A0A654E741_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-O-beta-D-mannosyl-D-glucose phosphorylase</fullName>
            <shortName evidence="4">MGP</shortName>
            <shortName evidence="4">Mannosylglucose phosphorylase</shortName>
            <ecNumber evidence="4">2.4.1.281</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man-Glc) to mannose 1-phosphate (Man1P) and glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32531"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:64351"/>
            <dbReference type="EC" id="2.4.1.281"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.281" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00928">
        <property type="entry name" value="Man_Glc_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028583">
        <property type="entry name" value="Man_Glc_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="44453" checksum="55FD243CC4B582D8" modified="2020-04-22" version="1">MSDAFNKIKKLIADHEAFLSIKNEPTADTNGVYQRYKNPILTAAHTPIHWRYDLNPETNPMLMERQGMNAAFNSGAIEFNGKFCLVVRVEGYDRKSFFAVAESENGIDNFRFWDHPITLPETHEPDTNVYDMRLTRHEDGWIYGLFCTERRDHSASEADQSAATAKCGIARTRDLVAWERLADLDSGGSQQRNVVLHPEFVEGKYALYTRPQDGFIDAGKGGGIGWGLVSSMENASVRDEKIIDPKIYHTIKEVKNGQGPPPIKTNEGWLHLAHGVRNTAAGLRYVLYMFMTALEDPSKVTHRPAGHFMGPLSDERVGDVSNVLFTNGWIAKESGEVYIYYASSDTRMHVATSTVEQLVDYCKNTPEDGLRSATSVQTRNELIDRNLAFLKANGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7E2</accession>
    <name>A0A654E7E2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UnbV_ASPIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="527"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122141" checksum="D69C857322637224" modified="2020-04-22" version="1">MYMRQPAIIFFLICLAFSCVPSEEEPSDKRFRLLKSTGIDFQNTLDYTEDVNPYTFKNFYNGGGVGVGDINNDGFPDVFFCGNMVSNRLYLNKGTSSEVGIAFEDITESAGLLSENVWSTGVTFVDINYDGWMDIYVCKSGPPGGPNRRNSLYINNRDLTFREEAEKYGLDNLGLSTHASFFDYDRDGDLDCYLLNNSIRSVGGYDLIKDQREIPDSLGGNMLLRNDDNRFVDVSAQAGIYSSSIGFGLGVTISDIDMDGWLDIYVSNDFFERDYLYINQQNGTFAESLTSYMTEISMGSMGADIADLNNDGYNEVFVTEMLPERHDRVMSKASFEGWDKYQLQVQQGYYHQFGRNALQLNNRNGTFSEVSRLAGVEATDWSWGALIFDMNNDGHSDLFVANGIYKDLLDQDYINFMANPDAIRKMLQDDGNAIKKLIDMIPSEPLANYAYENQGNLEFKNAASDWGLDQLTFSNGSAYADLDNDGDLDLLLNNVNMPAFVYENRTNGQGNNFISIKLQGKGRNPNAIGSKVWVYGGGRGWSRELTPMRGFQSSVDQRLHFGLGTLDRIDSVVIQWPDGRESRKLEVDVNRLVEISYASLTDTRVPGLNERKGTFQAVDPSVVPYLHTENTYVDFDRDRLLFDMASNEGPCACKGDVNGDGLEDVYLGGARGQAGRIYFQQRNGTFIEGQRFDAEAGSEDTDCAFSDFERDGDLDLIVASGGSEFTGLSLELRDRIYTNIGGKFQLMPEALPGTELRSTGTVAVSDFDGDGYPDLFLGDRLKPQYFGLPVSGHLFQNKGDGTFHEVTEEIAPLKEIGMITAAQWADIDGDGDEDLLLAGEWMPLKVFINQDGSFTESLEAGFSNSSGMYHTLQVADVDGDGDVDVLAGNNGTNSRFRATIDAPMRIYVGDFDRNGSIEHITAYYRDGAYFPMIQLKDLIKQLPGMKKKFLRYEAYKEANMTDVFTPEQLEGAVTYEIVDLETSLYLNDGSGIFTKAALPREAQFSPVYAISAGDYNGDGKMDFVLGGNQHMAKPETGIYAGSYGQLFLGAGNGDFRYTYPNESGISTTGDVRSILEVNTNGRPLLLFLKNNDQPYIVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E839</accession>
    <name>A0A654E839_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="5902" checksum="1EA52B293AEF3F6D" modified="2020-04-22" version="1">MSKSTRNTLRLISVIIVLALVLMELNVIPNLLNYKFWFMVAAYALALITYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA45</accession>
    <name>A0A654EA45_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sod_Cu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024946221" description="Sod_Cu domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="2">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="21379" checksum="C3772CBA097B6DFA" modified="2020-04-22" version="1">MIKFIPLITLLLLLVSCKEDTQTPDQPDTTATAYLYGMLSVTDSTYLIGEAPYGQATFSQKDSVVTITIALEHFPPNTIHAVHLHQGGCEMPGMHWNLGEPMTTRFCNETSLGIPWAKPMAGDVGNVSVGYDGSGVFTIKTDLWRLGSQDHRDILGLSIIIHEAYEDFITECDPSHTHNHTHPNAKVACGIITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBB9</accession>
    <name>A0A654EBB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="81" mass="9674" checksum="038A64EDC129B581" modified="2020-04-22" version="1">MNLRAYLIGKKIDPDRLKSNESDLYKSFNIIFSQMHPDSFTAQKLFLINKLRRKYRLEKEPEENAVKQVKKVKPKIVPRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBV6</accession>
    <name>A0A654EBV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="395" mass="44007" checksum="BC037F81B8AEEB98" modified="2020-04-22" version="1">MTAPDIWQPSHADFIADPYSRYSKLLDRSPVFQAITGDYVVLSYEDVKQVLLDKTCRSGARAEWTEKMREYGATRGMDYSKSAAGMAGMLIQMNPPVHTALRAALSKHWPDKESLSAMASVICADIVGSLPTGSFDLVPEVSKKLPLFMICDLMGIPREDGKNLIDDGFQMVQLLDPYLSIKDLKKIENAASHLHRYFHQFLEKVDPQADALSGAIKTLYPDREDAIGPMIFLFIAGFETTSALISYCLKQLIEEKSLASQLRADHDLIERFVLEMLRLYTPVQLTGRTNTQAMVLSGVEIPENSTLTLCIGSANRDPAHFPNPNQLDLNRNKYDHLAFGYGIHHCLGRQMAQIEAIELIKSMLPFVDQLSIAVPPPAKTKLTIQSVTSLMVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECT7</accession>
    <name>A0A654ECT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="21489" checksum="C36AD2184FEC50C5" modified="2020-04-22" version="1">MIYIFEGMDNCLKDTLIQELRTTLSGKTHVLKYSGPPSSVNAEAYQREHFKDMFDLLNLVMDDSLRSLILNRAHLGEAVYSPLYRGYSGDWIFDLEKEYLKRRKNQENIQLILLYDSNNEALISREDGKSFSSNNNTMLSKERDLFIRAFSKSQITRKLQVDLSDYQKNEQISTEQIMAELQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEA2</accession>
    <name>A0A654EEA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M28 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025066291" evidence="7">
        <location>
            <begin position="18"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="8">
        <location>
            <begin position="256"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="49937" checksum="C31307B1FF908D2F" modified="2020-04-22" version="1">MKKALFLILFLPLGVFGQDHTAMIKKIYDHQLSESPVYENLRALCKEIGPRLSGSPQAAAAVEYTRQLMVDYGFDTVYLQPVMVPKWVRGSTEIARITNSDKVGTRELRTVALGNSVGTGPAGVLAEVVEVKSIEEVNALGKAVAGKIVFYNGEMDPTLVNTFQAYGSAVVQRAYGASEAGKFGAKAVIVRSMTNRRDDIPHTGSLVYRPLMPQIPALAISTNDADLLSDLLQDQKDLKIYVETHCELQEDVLSYNVIGEIKGAEFPDEIIVVGGHLDSWDVGEGAHDDGGGCMMSIEVGRTFLALGIRPKHTIRIVMFMNEENGLRGGKEYARVAKEKGEKHIAGLESDSGAFGPMGFSSMGEETSRDKIKSWKPYFLPYFVWNFDKVGSGADISPLEDQGVFLMEMEPNPQKYFNYHHTEADVFEAVDKRELELGAGTMTAMTYLIDQEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSN7</accession>
    <name>A0A654DSN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024825909" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="351"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="867"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111600" checksum="67714CE1A283D7F8" modified="2020-04-22" version="1">MKKLILLCLALAFHGIYAQETFPVNGVPDERSGHYAFTNATIFVDYQTKLENATLIIKDGKVTAVGTGISIPKGAITVNLEGKYIYPALVDPYSNYGLPEVFTSRSRGKPQYESSNKGPYGWNDAIRSTYNASEEFALNEKEAEGLRKAGFGAVNTFSPDGIMRGTSLFTNLSDAPVQDAVLSDKVAAHYSFSKGTSKQEYPGSIMGVVALLRQTYYDAAWYRTQGSAEQVNLSLKAFNDVQRLPQVFEANGGKLRVLLADQVGDEFGVQYIIKGTGDEYQRISEIKKTGASLIIPVTYPEAYDVEDPMAALDVSLEDMKHWELAPINASMLAKAGVEFSFTPSGLKNTDDYWKNIRKAVTYGLSETQALKALTYTPARYFNMQQRVGGLKQGMMANFFVASESIFEEKAKIHQTWVQGRKYEISDLSTPDYAGKYNLKVGDTSYALEISGEAGSHSAKVVVNDSTDLKVKLKIEENRVTLIFKLEEEEANTRLTGWVDPGAFGGTGQLADGSWTKWSAARVGDLDEKEADKDAEDKEEEEDQTPDLGKMIYPFVAYGWTEQPVQETILFKNATVWTLEGDGKLEGADVLVKAGKIASVGKGLAGEGAKVVDATGKHITPGIIDEHSHIALSSVNEGSHAITAEVRMYDALNSEDVNLYRQLAGGVTAAQLLHGSANPVGGQSALIKFRWGASPEGLKIKGADGYIKFALGENVKQSNWGADYSIRFPQTRMGVEQVFVDGFTRAKAYGEAKARYEGLSKKMKASTPAPRKDLQLETLLEIINSERFITCHSYVQSEINMLLKVAESFDFRINTFTHILEGYKVADKMAEHGAGGSTFSDWWAYKFEVKDAIPYNASLMTMAGVVAAINSDDAEMARRLNQEAAKSVKYGGMDEISALKLVTLNPAKLLHLDDRMGSIKVGKDADVVLWNDHPLSIYAKPEMTLVDGVVYFSLEKDAEMRKQISAERARLIQKMLDAKNGGEKTQKPKKKDKHYFECEDIIEEGFTLNHQDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSR8</accession>
    <name>A0A654DSR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Azurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13922">
        <property type="entry name" value="Azurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014068">
        <property type="entry name" value="Azurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02695">
        <property type="entry name" value="azurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024925421" evidence="1">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="18262" checksum="D8D4A05E1B40FBA5" modified="2020-04-22" version="1">MKKSRLYVCLLAGSALIYACGGGSQKQSAESTDTAVAEVPAEVVVDSVTLEISANDNMQFSTDQLKVTEGQVVTLNFKHTGKMPKESMGHNWVLLAAGSDPAVFGAAATTAPKTGYIPQDKLEWVIANTPIIGGGEEVSISFQAPKAGYYKFICSFPGHWGVMQGDFVVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT54</accession>
    <name>A0A654DT54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisF</name>
        <name evidence="11" type="ORF">MARINOS108_10262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="27077" checksum="F863830D0737FC3A" modified="2020-04-22" version="1">MLTKRIIPCLDIKDGRTVKGVNFVDLRDAGDPVELAERYTREGADELVFLDISATLEKRKTLLELVRKVAEAIHIPFTVGGGISSVADVRALLNEGADKISINSSAVKNPDLIDELAAEFGSQCIVVAIDSRNVDGIDWVHTHGGTRPTELETIAWAKEVARRGAGELLLTSMDHDGTKAGFAVDLTQRVSQAVNIPVIASGGGGDESHFVEIFGAGEADAALAASIFHYQEVEIMHLKDELIKNNLPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT71</accession>
    <name>A0A654DT71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin bcp</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp</name>
        <name evidence="5" type="ORF">MARINOS108_10276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="16721" checksum="C91594EC0A505E47" modified="2020-04-22" version="1">MKLQAGDQAPDFTSIDQDGNPISLSDFKGKKIVLYFYPKDNTPGCTAESCNLRDNYANLQKQGYVVLGVSGDSAKSHKKFIEKFDLPFPLIADEDKSVHEAYGTWGEKQMYGRTYMGTLRTTFVIDEKGMIEEVIAKVKTKDHTAQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTX6</accession>
    <name>A0A654DTX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="34025" checksum="7B05A6B1202045D1" modified="2020-04-22" version="1">MVLAANSHLVVCRACSKHTNQNMEKFTFVILCILLSGVQTTFGQHKTEIVIGSKFVIESNILDEERTCLISLPDSYNDSCLASKKYPVIILLDGYTHFKTASGIVHFMSSKRNRNNLMPESIIIAIENVDRERDFTVTKIKTKRPNTMGGGRSFLNFIENELIPYVDENYRTEPSRTLIGHSLGGLLTLNSYMDENSVFNAYISIDPSIWWSEEMMKNKVDSISSISLNKKLYIATANQGEANYERNKQRHDNLYTLITKRSEEPLNVEIKYFEKENHRSVPLIALYEGLMYINQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU31</accession>
    <name>A0A654DU31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4753" checksum="8094DB1D0B753199" modified="2020-04-22" version="1">MIDNHPSLGRTPLKMFVPDDSRFEIQTWGQNLYLFWRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU60</accession>
    <name>A0A654DU60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024984644" evidence="1">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="35140" checksum="D9C82563956CD390" modified="2020-04-22" version="1">MTKHLYLFILAVMLSLSGRACDVCGCSLSGLYFGFLPNQNTHFVGVKYSHASFSASIDNDGYYYEDEHSEDTYQRYDLMGRFSLAERFQVRYLMPYMINNMEGSHQTVHSEGVGDPVVVIYYSPFNTGNDFSRAIMHSLNVGAGLKVPVGEFDKEDNGELVNRNFQLGSGSLDYVLSANYTIRHGNLGINAETSFKMNTPNTQAYRFGNQFNLSGNAFYYLEMKKVSLVPFAGVYYEAADRHKYHDIIEANTGGSSLLGTFGVQLFAGRVTTNVQYQVPLIQSFNTDDFAEIEGGNRLTVGLYYSFSFKNNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU72</accession>
    <name>A0A654DU72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAAT_C" evidence="1">
        <location>
            <begin position="98"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="30393" checksum="3EE11EAB99048474" modified="2020-04-22" version="1">MMKVVSIFFSLVLLMTCNDGTTDRSGVDTQLYLGDGDHQPLIVAFGGGDGGNGWTSDRVKDKREQLIAKGYAFLAVGYFGTAQSPGTLDRISLDAIHDAILSVANHRKIDRNKIALLGVSKGAELALLLASHFEDISCVVAMAPSHCVFPAHTFMASTSSWTYQGEEVPFVPMTWGAVPAAIQHDLLSAFSIMLKDTEAVEKAAIRVEDIKGSIFLLSAKNDEQWPSTPMSLAAIERLAKNNFPYPYHHVAIDGGHFEVFDHFDSVYHFLDQNFPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU80</accession>
    <name>A0A654DU80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024840874" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="118"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="417"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113020" checksum="E2B80D721530D217" modified="2020-04-22" version="1">MMKLYKQLFLMCLTFGVLQVSAQQRISGKVTDEQGLGVIGASVFVENTTYGTITDIEGNFAFSVPDSLSESNLMFSFIGYHTEKRPISGRSQINVQLSLDNKQLEEVIVVGYSTQTKGDVTGALNTVKGKDLNSLPVAGIDQALQGRAPGVNISQVTGAPGEGVSVRIRGIGSLNSSNDPLYVVDGVPTREVLSILSPQDIEEITILKDASAAALYGSRANNGVVLITTKKGSKDRSSITINSQVGVQMHGKLTEMTNRDQYVEMYNEAATNDNAFVSDDLFKRDLIPLDYAASQPDIDQMEAIFREALIQNYGITASGGNEKSQYMLSVTYFDQEGIIIGSDYDRLTGRINLNTEVKPWFTTGVNLNIARSHTSSIGSSGDGAGGNGGSIVRYAYFRTPAIPIYDEEGNYTDLPEYPSFFGDGYNPVGLANYADNKMTTDRYFGKVFGVLDLGDHLTLTTNFGFDSESGLRRRFDRNWGSNDRINNPNRLLVANTSAVTWTNNNVLQFKKSFGLHDFNALLGTEAIKSQGYFSNQTGRDFPDQDPNLTYLGNGQGTAAVSEGRYAYTLLSFFGKVDYDFDSRYQLSGSFRRDGSSRFASENKWGTFYAVSGGWNLHNEAFLSDVDFFSQLKLRVGYGEIGNQEIGNYAYSDQIQPNYNYPYTSAPSDGYSVTQLGNTEVKWESSRQYNAGVDFEINQGVLYGSLDYFHKLTTDMLVKEPNPPSAGYSDPAWVNNGEILNQGLELLVGVRKTMADFGYNFSGNVALLHNEVKSLDGFISGGAIGSGNYTTRTEVGQSIGSFYMLEMEGIFQNELDIATSAFQGNNIHPGDVKYKDQDGNNFIDENDRVHAGSPIPKVTAGLNLSVSYKNLDLIAFFQGAYGFDIYNVAFHDIEGFYRPFNLTKDYYDNRWTGEGTTNEYPRASWSGSNNNVRISTRFLRDGSYTRLKNLQLGYNFPQPITEKLKLNRLRVYVSAQNLLTITGYSGLDPEMTTSDNATGEGDLARGIDWGTYPTARSFNFGVNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU87</accession>
    <name>A0A654DU87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="384" mass="42003" checksum="AC6603E4A436102B" modified="2020-04-22" version="1">MELKVKQRIALSTYFFLSGFGFATWTSRIPTIKEALGLNEAELGSILLVMPLSSLLGLPLSGFLVSRYATRGPMFAAFLCYAVSLFSISFVDSTAYLVVTIFLVAFFMRIINVSMNTQAITLQKSYDKKINGSFHALWSMGGITGVGFTTLMIYGDVSMPIHFLVFTLIAIPAGYVAFRHVLRNDRATTGNKLILRNPDPYIMALGVLILFAAICEGGMFDWSGIYFREVVHAEVFTFGFLLFMICMTLSRFTSDWVIHWIGIQKTFVVCALFIASGIGVAVVFPSFYPALIGFSLIGFGAAPIIPMALLQAGESKKYSPGIAVAIISTYSTSGMLIGPPIIGYLAHAFTLRYAFLFLLVMGLGMIPVSRFFFKIKAKGSGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP8</accession>
    <name>A0A654DUP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="89"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="381"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="498"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="861" mass="97630" checksum="487B94A28C4566F9" modified="2020-04-22" version="1">MEPYNQKGLPRLALLLISRLCKHDLQEEILGNLEESFHNHGSKTRLWRECLLYLRPSCLKNIHLSSQHPMFIFNPLLTIRNLRKQGMNTVINIAGFTIGLLCVFFLYFYVSSELKYDTFHKDYHEIYRVLRTAEMNGSPFKIGVTSGPYARALETDFEGKIHTCRASLETSLVKYKDKQFFEEHILFADADFFTFFSYPLATGNPESVLSQANNVVFSKALARKYFGDEDPIGQIIETEGEQFIVTGVMDKIPSKSHLEFDIILPFAFLDKYEWMSNWWNNGLITYAKFTSPKDRQYVEGQLQWFMEKYMGDDFDQTKSRIGLVLEPLSETYFASDVRYDLARHGDLTSVYILAMVAVAILFIACFNYVNMSVALSFKRAREVGIRKIMGGKKGRLIVQFLGESLMVILVAVFLAGGLSQLFLPLFNSLFGLEVTYNWSDPNIMLFIGALVALVVLSSGVYPAILLSSFKPLRVMKGEMIKGTKGVFIRKGLVVTQFVIAIFLIAVTFLVTIQFQYMKNKELGFDQESIITIDINNGDIRKQIDTFKERLLANPAIESVTAVSGEPGGFHDGASLQFSGIEEQLKIRTLFADYDFLETLNVQLVEGRDFDRSFGSDMNGSVLINEKALEELGISAEEVLGQTVKMPLWDDYNRKVVGIVEDYHFQSLKSPIEPLCIVLGGRPRKVVVRVQAGSLNQGLEHMNNTWEELIDGFPMNYSFLDESLSRLYENEQKQHHVFTTFSVISLFLATLGIFGLVTYSAQRRQKEFGIRKVLGASVGEILSLISKEFTILILLAFMVSIPLAWLFVTNWLEAFSYRIALEDYWYVFAASGIVSLVVALLTIGFRSLGVALSNPSESIRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT1</accession>
    <name>A0A654DUT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycerol uptake facilitator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glpF</name>
        <name evidence="8" type="ORF">MARINOS108_10768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="24511" checksum="76E6315B83E2AF1C" modified="2020-04-22" version="1">MNPIVAEFVGTFILLLLGNGVNANVSLNKTYGNSSGWIVISMGWGLAVFVAVFIAGSSSGAHINPAVTLGLALVGRFSWSAVPVYLMAQLLGAFAGAWVTYLQYRPHFSDTADQNTKLGIFCTGPAIKSTLNNFISETVGTFTLVFAVFYLSSGEGLGSLNALPVALLVVGIGLSLGGTTGYAINPARDLGPRIFHALAPIRAKRDSNWPYAWIPIVGPLVGATLAAGLYTLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV91</accession>
    <name>A0A654DV91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="34607" checksum="F63C864A7210732A" modified="2020-04-22" version="1">MKSINVLDLTEFESHGDPIDFHCNTFTRHLQAHHGAITVPHKHNFFLIVLFTSGSGLHEIDFEKYRVTPGSVFFLSPGQTHYWELSDDIEGLIFFHSQEFFDLSFTDRSVYDFPFFYSQLNSAVLQLNTTDTHKMAARFNELLTEYSGKNTFMTTQKLSSLLSLTYIELSRLYLAQGQMEVSKTGVHSEHLRKLEKLIEENFRTEKSPGAYANMLHMTVRHLNRLTQGSLNKSPTQLITERILLEAKRMLVHGTSSLSQISYDLGYEDYAYFSRLFKKWTKLTPSAFAQQYQSGRSRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC1</accession>
    <name>A0A654DVC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_10624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="6">Binds 2 heme groups.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Binds 2 heme groups per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026259">
        <property type="entry name" value="MauG/Cytc_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000294">
        <property type="entry name" value="Cytochrome-c_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="9">
        <location>
            <begin position="210"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD11681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="349" mass="39419" checksum="D2F7DF16F416B345" modified="2020-04-22" version="1">MIDLLKKYPAYSWVLLLILGSCSGESIDPGEEFYKFEKPAHFPEPTYTFENNPVTKEGFELGRRLFFDPILSRDKSVSCNNCHQQSRAFADMPLHGMSIGVDNQAGFRNAPMLANLAFMREFFWDGGVSHLDFVPINAIESDVEMDESLANVVSKLNQDDRYPGLFKEAFGVDEVTSPYLLYALSQFTLLMVSANSRYDQYILGKGELSTEELEGMQLFDQKCATCHSGELFTDFSYKNNGLSSSFKDLGRGAITEDEADYGKFRVPSLRNAEITAPYMHNARFSTLEEVLNHYEQGIKGSPTLDPIFMEDGKVKGIALTEDEKIKIISFIKTLTDRDLISDPKFQNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW08</accession>
    <name>A0A654DW08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-bound serine protease (ClpP class)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024888105" evidence="3">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="354"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="48957" checksum="B891BAC82DA21C76" modified="2020-04-22" version="1">MLKKYIFFFFLISGLLVQAQDSSQVNVLHLKVLDNIDPRTNRYTELGFEKAKEMEADYVILELDTYGGALNDADEIRTRILNFDKPVYAFINKDAASAGALISIACDSIYMAKGSSIGAATVVTQDGTAAPDKYQSYMRSIMRSTAEAKGRNPHIAEGMVDEDIDLDSIATEGKVVTFSVSEAIRYGFCEAEVSNIDEIMSRSGVATYDITEFKLSLTDRIIALFLNPFVSGILILVIIGGIYFELQTPGVGFPILASAIAAILYFTPYYLNGLAENWEIIIFFAGVLLIAAEIFVIPGFGIAGISGLILTLGSLILVMLNNDTFDFSFVQVDDIFIAVATTLAGLMGSIVIMFMAGARLTNSRFFNRIALQDIQDQTEGYTSSFYKSKSMVGKKGIAYTILRPSGRVEIEGEIYDAYTRGNYIEAGIEIEVISDEGTSLKVREAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWA1</accession>
    <name>A0A654DWA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="26248" checksum="661628BAE256042B" modified="2020-04-22" version="1">MRPILVIIGLIISLSTYCQSLIDKMGLESCKCLNTINADGDSEQTWEKFNTTCWSRIIEQFKDDINALEFDTTDTEIAEVPEYKRGYELGKIVGVRVFTNMIDNCDEFYEIFKKMIPKVIDPNTVPIYGEGEIDSLTNHIELGINLFDNYCDRAIAYYKKSKTKKAISDLDKAIELKPDQPTPHIYKGIIHRNNKKYCSAAKEFETAYQLGSNPMILIFSRILIRECGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWH3</accession>
    <name>A0A654DWH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016944">
        <property type="entry name" value="UCP030066"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030066">
        <property type="entry name" value="UCP030066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13832" checksum="B651037BA2659B8E" modified="2020-04-22" version="1">MTKRNKIIYWIATLWLALGTTSTGIVQLIKMDEEVAKMTQLGYPSYILTILGTWKLLGVVAVLIPRFPLLKEWAYAGFFFNMSGAIFSHLAGGSDPIEFFGPTLLIVLTVVSWYFRPADRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN0</accession>
    <name>A0A654DWN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="24603" checksum="DE89C08A84A3A13C" modified="2020-04-22" version="1">MKNKIRILLVDDHPMIRDAIRQYFSTNEEIEILDEANNGQEALQKLEEKDFDLIITDMAMPDMNGVEFMTALQDRQIKQDVLVVSMINEVSQIKKMISLGAKGYVLKNSPKEEILKAIKTISGGENYYTREVYDIIMGQLSGKKPALQRISLEVSLTKREKEIVRLIMEEHSNQVIADMLFISVRTVEAHKRNILEKTGCKTMAGLAIYAIEKGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY7</accession>
    <name>A0A654DWY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="67"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="29248" checksum="8BE82AB22D0D38BF" modified="2020-04-22" version="1">MKLIYLFCLIFPLSCMEADDNRPENEEKTKDETPANDDSEPEGEESSENEENNEDTTMTNGSISFLALGDSYTIGESVEIAERWPVQLVTELRERGVEMKDPEIIARTGWTTAELQGGIDNSEVKGPYDWVSLLIGVNNQYRGYSISIYRTEFESLLQQAIDFAGGDKRRVIVVSIPDYGVTPFAANSDRAKIAREIDDYNNMAKGFSEAYGVTFFNITPISREAATKPEYVAEDGLHPSGEMYAAWVQMILPHALEILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX11</accession>
    <name>A0A654DX11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent M28 family amino/carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="129"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="295"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="542" mass="59938" checksum="2D693A70AE3DCCFA" modified="2020-04-22" version="1">MKKYYGLLVLGGLMACEGYQQTTEKVLVDTVAMANHVRILASDNFLGRKPFTEGETKTLAYLENEFKSYGLEPGNGDSFFQEVPMVELNASPSPTLEISGANGSVSLNVSDEFVAYTERVEEVSALENSELVFAGFGVVAPEYGWNDYEGLDVKGKTVIVLVNDPGFGSGDSTFFKGQTMTYYGRWTYKYEEAARQGAAGIFIIHDTAPAGYPWLVVRNSWSGASLYLDQTAGQYKPLVQGWLTREAAIKIFEASGKDMKNYVEKSRSADFTPTALDMTASVTIKNEIKRASSKNVIAMVKGTEKPDEYVLYTAHWDHLGVGQPIDGDSIYNGAHDNASGTAALLAIAKAYASNPEKPKRSVLFLAVTAEEQGLLGSKYYAETPIYPPAQTVANINMDGLTYFGLMKDFTVVGYGQSELDDLAGAIATQQGRYIMPDQEPGKGYFFRSDHFQFAKVGIPAMFASGTYEHMTKGVEYIEEMSNEYLTNRYHRPADEFDAAEWRFGGMLQDASLFYELGWQLANSDQWPKWKEGSEFKAIREGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX34</accession>
    <name>A0A654DX34_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">deoC</name>
        <name evidence="4" type="ORF">MARINOS108_11505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="23446" checksum="7A7FB0C07EE75595" modified="2020-04-22" version="1">MNQLARFIESTNLNPQITGKEVDFLVSEAKDLQVLGVCVPPFWVKRASREIASADLQLVTVIGFPLGYQMTETKIEEARLALRDGANELDLVMNVSAFKDGMPWPKVEFAKMSKLAHEHEALLKVIIEVAYLSDEEICRAARLCADAGVDFVKTSTGFAKGGEATVEHITLLRGTLPSSVGIKASAGIKTRTQVEKLLAAGADRIGTSSARDILMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX40</accession>
    <name>A0A654DX40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="395"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="581" mass="65939" checksum="FE7B23A21632B08E" modified="2020-04-22" version="1">MKILYLEDNTSDYELLDLSLQKSNLEFTLDRAENKAQYQKALETHYDIIISDYNLQGFTGTDALKMLREKDQSIPFVVISGTVGEEQAVSLLHYGASDFLLKKNVKKLPIIIERVLRNKMIDDERRNFQKELINKNLILDSLFNSFEDMVFLKDTNGTYLKVNTAFSRFFGFTEKAILGMTDGNLFDKNIAEKAQETDEHVRNNKLSITYEILFTGTDGVSRILEVVKYPVLDGNEVTGVVGSSRDITERKMLEEKNAKSQYILNQAEQLTYSGSFQYDSEVDILSCSPHFVKMMGIPGNINKISLMKFLGLVYKDDHKIFNDEIDKVLDKKVTVTIDHRYIPNGSKQIRYGRTTISPDYSTGNASIFYGTIVDTTSDYENDMALLNIQELERSNIANELHDNLGQKMSASALFLDGLVSKYPEDTELTKVANMINTSLTQIRSLSNTLSLSSIKEMGLEDSLRQLQDQIPLSIEFELHYSVDESSISEFISTQTFRIIQEAINNIQKHSEAKRIEIDIAQAQSVITLKIRDNGKGFDINAGVRGNGIRNMEQRVKKCNGLIHIDSKINEGTFIDIKLPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA6</accession>
    <name>A0A654DXA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SatD family (SatD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032580">
        <property type="entry name" value="SatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16264">
        <property type="entry name" value="SatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22440" checksum="16CB6049E70401D8" modified="2020-04-22" version="1">MITGVITGDIINSRKAESTEWLTALKSALNRYGTTPKTWEIYRGDSFQLEVPAEEALFAALYIKACLRQYKDLDARMAIGLGEKTHSASRLSESNGSAFRHSGECFDSLKKSTLALRSEWPELDQEVNAYLSLALLTIERWPANASSIIKIAMENPQLTQTELAKKLGKSQSTISESLKRAGFDEIMQMEKQYRNLIANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF8</accession>
    <name>A0A654DXF8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="17573" checksum="9A4539443C06A4B5" modified="2020-04-22" version="1">MKINANNPGEYISQLPDERQEAFQKLRQTILDHLPEGFEERMSYGMIGYVVPHERYPAGYHCDPKLPLPFINIASQKNFIALYHMGIYANPDLMEWFTTAYPLHCKTRLDMGKSCIRFKKVNDIPFELIGQLVSKVTAEEWIQCYETRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ4</accession>
    <name>A0A654DXQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="36173" checksum="5A3FD444C93D9EF2" modified="2020-04-22" version="1">MEKVVRQPFRNPAYQAKFEQDGYVIFDLLSDAQLNHIRQHVESTPLPDTKGYGFNVAMDSESLSLRKEIHHFLIDFMHPISAEILIDREPYSTSYMIKEANSGLVPAHQDWSYTHEEQHASIMCWVALDDVDLENGAMAFIPGSHQLFDYKRVFPFPYAKTPVERFKLELMSYLQIEPMKAGQVVFFNNKTIHGSFPNNQPKRRYAFCMSFSVTNEPILHFQFSDPQNLNQITEYEVGNDFFVIHNNETLTKTLLHEHGNLKDGTLKKSEPYYLPELNWESLESMLHERGIYRSEILQERLRQFLNKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ5</accession>
    <name>A0A654DXQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024864849" evidence="1">
        <location>
            <begin position="26"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="462" mass="50598" checksum="44C2ECFC68FF4680" modified="2020-04-22" version="1">MKKLTNHILLLLAAAIMVSCSGSDAKNQSTDVVSATESGASALLIEKPQLTFGFIKLTDMAPLAIAKELGYFEDEGLFVTIEAQSNWKNVLDRVIDGQLDGSHMLAGQPIAAGAGFGRQAELVTPFSMDLNGNGITVSNEVWSKMKPNVPLDESGKPIHPIKADALAPVVKEYKTAGRPFKMGMVFPVSTHNYEIRYWLAAAGIHPGLYTADNIQGQVDADVLLSVTPPPQMPATLEAGTIYGYCVGEPWNQQAVFKGIGVPVVTNYDIWKNNPEKVFVMTKKFVEENPNTAIAVTKALIRAAKWLDTPGNRPQAVGILSMPAYVGADSVVIANSMTGTFEYEKGDKRSMPDFNVFYRYNATYPFYSDGIWFLTQMRRWGQIPESKPADWYHSTIKDIYRPDIWSKAAKILAEEGKIPATDIPETDGYKPATSDFIDGTTYNGKDPIGYINSFGIGNKDQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY85</accession>
    <name>A0A654DY85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22300" checksum="69E75673C31E5519" modified="2020-04-22" version="1">MEIKNKFILISLGIILAPAVILLFWNPPGHYEQTKEARLMRDLCNEVASSETLRAQDDFNKLIELISVHIHQYADNSNETVARAVMELRALQNEAEFRTIDVDMYHRKFARILVELAQVELEDAIGFEAQHQAYGVKKSVREAKHYLHDALIFSRTSSLSHQKELEYEFEKLSISNVSNEQIRNCIAATQKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR1</accession>
    <name>A0A654DYR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4970" checksum="F25C166C2608EC33" modified="2020-04-22" version="1">MRISSAFFKINLERNENQSIYNPTNTLLKYYQSGRWAKWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ3</accession>
    <name>A0A654DYZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative copper-transporting ATPase PacS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pacS</name>
        <name evidence="9" type="ORF">MARINOS108_11594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="749" mass="80792" checksum="0D01ED77704B33F6" modified="2020-04-22" version="1">METVIEKSSATSHQVIKESFPVTGMTCAACASSVESMISHTPGVKKASVNFATNSVLVEYEDSITQETLRQAVQSIGYDLIVGEDDPSAMQQELQQKHYQDVKKRTIWSALLTLPVFIIGMFFMEWTEGRWISLALTIPILFWFGRTFFINAFKQARHGKANMDTLVALSTGIAFIYSLFNTLFPEFWHSRGIHPHVYYEAAVVIITFISLGKLLEEKAKSNTSSAIKKLMGLQPKTLKALIEGEEVEIPISSVQVGYTIIVRPGEKIPVDGEVIGGESFVDESMITGEPIAVSKAKGDKVFAGTINQKSSFQFRAEKVGGETLLSQIIKMVQEAQGSKAPVQKLVDKIAGIFVPIVMGISIITFITWMIVGGDDAFTHALLTSVAVLVIACPCALGLATPTAIMVGVGKGAEHNILIKDAESLELAHKVNAVILDKTGTITEGRPVVTDMIWGTSESNVDRSMQILLGLEAVSEHPLAEAVVNKLKADNIQPAEIEAFESITGRGASAVSGEVLYLVGNRKLIDEHHISISLPLTQAAGRLQQDAKTVIYFADEEQVLAVLAIADQVKASSRQAIQTLQHRGVEVYMLTGDNHQTAAAVAEQVGLQHFKAEVMPSDKADFVKALQARGKVVAMVGDGINDSHALAQADVSIAMGKGSDIAMDVAKMTLITSDLMSIPKALNLSSKTVMGIRQNLFWAFIYNLIGIPVAAGVLYPFNGFLLDPMIAGAAMAFSSVSVVANSLRLKASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE3</accession>
    <name>A0A654DZE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_110083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="533" mass="61308" checksum="3EC995A68FDF830E" modified="2020-04-22" version="1">MSKQLLFVGLCFISFWGFSQDSLYVDLSSPYAAVRTHLYYLQEDHYNENLAAVPFGLSGIKKEDAIESAIKLKQIWDGEGTYINMDELPRNPNYRDSTRNRAQYVISKDRPEIFLEKQGNQWMYSKSSIGSIDELHDEVFPFGTDKLLELLPKMGTRKIMGLYLYQYLGMLILALLCVVIHKIFTFLFEQLITRMLLNAGYERLADRFLLPVARPISIFVVILLLRVFLPVLQFPPDVAHWSMLILRALLPLFGTIVFYRLVDILAMYLENLARRTESTLDDQLVPLLRKTLKTFVVGVGTLFILQNLDIPIIPLLTGLSIGGLAFALAAQDTIKNFFGSLMIFIDRPFQIGDWITSGEIDGSVEEVGFRSSRIRTFRNSLMYVPNGKLADSTIDNHGMRQYRRFYTQIAVTYDTPPELIETFVKGLRKIVENHPDTRKDYYNIYFNDMATFSLNIMFYIFFEVPDWPAELKARHEVLIEIIKLGKKLGVNFAFPTQTLQMEKFPGQQSLSPSYAGTAELEARMNDHFNTPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE5</accession>
    <name>A0A654DZE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="29276" checksum="D9295C32B41CE2A3" modified="2020-04-22" version="1">MKVLIIEDEAPAFRRLQKLLEEINPDIEIVEVLDSVEESVKWFNNHHIPDLIFSDIQLSDGISFDIFDRVPITRPVIFTTAFDEYMLKAFRVNSIDYLLKPIKKEDLEKSLLKYQQMKRVFGGGVDMSELLKNVKLGGQDYKIRFLAKVGDKLVSVETEDVAYFQTRHGVVHMATTQGRTYLLDQALDELMTQLDPNKFFRANRQFIVQFRSISAVHRYHKGKLLIELNPKLEEDVVVSAEKASHFRKWLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG7</accession>
    <name>A0A654DZG7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ddl</name>
        <name evidence="10" type="ORF">MARINOS108_10976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="156"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="627"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="885" mass="99274" checksum="A0F33B59DBBF3A63" modified="2020-04-22" version="1">MRIGIIFGGQSREREISFAGGRTVYDNLNKTLFTPVPIFIDSLGNFILLDWQYLYKGTIRDFYPSAEHLPHSPHFFQVYSESLQNEPDRLEKSMAAVGQKITPDQLSKHIDFAFLALHGPYGEDGNIQGILEWYGIPYSGAGILPSSIGIDKEVQKRVLKTAGFETPKSTSIERSQWLNSQSAVIQNLEREFSYPMVIKAPHQGSSIGVSIAQDKNSLLAGLNRSFFIESIDIASWKAKSDEQKRNFLVTFTDIREGLGFPVLVDGKMVYHPENLWELLDQSKESTLKLESPNGEALVLVESFIEGREFSCIVIEDETGAPMALPPTEIKKRTDLFDYRSKYLPGISRKITPIDLPDQDIERIMRKSEALFTALHSQVYARIDGFFTAEGDIFLNDPNTTSGMLPSSFFFHQAAEIGFNPSQFLTYIISRSISARLNAGKKIYHLLTLAQTLRTSLQQAAAHQGEKIKVAVIMGGFSSERHISVESGRNIYEKLASSGKYLPIPIFLTGDETKHLLYQLPINIMLKDNADDIREKITHHSEVTHPVIAEIRRKAHHLMEQFAYEEALQLESLTYDELATRVDFAFIALHGRPGEDGAVQEQLELRDVPYNGSGVESSKISINKYDTNELLRANGILVADHMLVYQEEYQQNPEKIIESITSRFSLPLIAKPADDGCSSAVKKIKTREELIAFAEMMFRTQEAFLPEPMRTLNLKANEEFPQKNFFLVESLISAEGADKFLEITGGMLTHLQPDGSLSYEVFEPSEALASGEVLSLEEKFLAGEGQNITPARFADTAEGYAAIAKSVKETLEKTARTIQVEGYCRIDAFVRISGQQADTIIIEINSLPGMTPATAIFHQAALNNMKPYEFIDQIIQYGFARHQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ6</accession>
    <name>A0A654DZJ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025022278" description="NodB homology domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="37"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="418" mass="44858" checksum="4EFCA83154CFD93D" modified="2020-04-22" version="1">MKSKYTALTAALLMSLSVGAQIDESYEVATWHGFKTSAVSYTFDDNTSNQLPVALPLFDQYGFKVTLYTVTNWGPDWTALQKASNNGHEVASHTISHPSLPSISAEEQEAQLQQSQSTIRSNVQGAEVLTLAYPNCNIGDLATIEKYYIAGRVCSGQIISAKPGDYYRLSSMIVGSQGEVNSTSAFQTKVELAKSSGGWAVFLIHGVDNDGGYSPVASSVLSEHVDFMNANSDDYWIGTFAEVVKYIKERESISISESAITADSLKVIISDGLEDALYNQAVSIRRKLPVNWSTASVYIDGAAIESDVQSENGISYVVFDAVPDQGVITIGSAGGPAIALATPNDISPVAFHPNPFSDTIQIKSGGSFKYSIYSLTGQQLSSGEGNNSIFVGKSLPSGTYLVRVNDHSSISQFKIVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN2</accession>
    <name>A0A654DZN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="5168" checksum="0AE6A00A7FF47977" modified="2020-04-22" version="1">MVRIPMNAQTVKEFSILNGNVILARPVYRSRKDFYTSKVYHRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS9</accession>
    <name>A0A654DZS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar porter (SP) family MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_110041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="48916" checksum="54142E7E7D65C006" modified="2020-04-22" version="1">MNRRILYYSIVVAMAGFLFGFDTVVISGANLPIKQLWNTSDWFHGTFIMSMALWGTVIGALAGGIPTDKYGRKTTLFWIGILYFISALGSALATDPYLFSFFRFIGGLGVGASSVTAPTYTSEIAPAKSRGQMVALYQFNIVFGILIAFISNYLLKGFDGINDWRWMMGVEAIPALAYILLIMGVPKSPRWLILHQKDHDAALEVLRKTNTEEEALALIAEIEKDGKASESIQGGVFSKRYSIPLMLAFLIAFFNQLSGINFILYYAPEILEKAGFASSDSLLSSISIGGVNLVFTILGMYLIDRAGRKQLMYIGSVGYIMSLLMVAYGFYAGASANFKLGFILMFIASHAIGQGAVIWVFISEIFPNRVRAFGQAWGCGTHWVFAALITLFGAVLINTFEPWMVFIFFAGFMVLQLLFVIFLMPETKGVSLEELQKRLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B5</accession>
    <name>A0A654E0B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GH3 auxin-responsive promoter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="498" mass="56211" checksum="928DA9C12EEF6345" modified="2020-04-22" version="1">MGIRSILSKPFAAYIARETKKWTGSAGAFQDKILKEIVTKARDTQFGKDHGFGEIENYEDFKKQVPIRDYEGLSPYVKKILAGESDVLWPGKPAYFAKTSGTTSGTKYIPITKDSIPNHINSARNALLSYVHETGNGRFLDGKLIFLSGAPTLDQKAGINTGRLSGIVNHHVPGYLRTNQMPSYETNCMEDWEKKVDQIVEETFDQDMTLISGIPPWVQMYFDRLKAKTGKPIKDIFPNFEMFVYGGVNFEPYRAKLFETIGKEIPSIETYPASEGFIAYQDSQKEPGLLLLANSGIFFEFIPADEYFNENPTRLKIDQIELGVNYALILNSNAGLWGYSIGDTVKFINKNPYRLLVTGRIKHFISAFGEHVIGEEVEQAMKATCALFPEVELVEFSVAPNVTPAEGLPLHEWYVEFATPPKDKLGFQKELDLQLRKRNTYYDDLISGSILRPLEVIDLKQNAFIEYMRSIGKLGGQNKVPRLSNDRQIADAMQQFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B6</accession>
    <name>A0A654E0B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="54" mass="6145" checksum="858E81DEBFC1C482" modified="2020-04-22" version="1">MYFLKNISIEGVNSVSIQGFQKVKSKCHFFLKNFILNFDVPLFSGSLFLGLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C9</accession>
    <name>A0A654E0C9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="6">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="PTHR15749"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="440"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="553" mass="64647" checksum="D7D01B0338BB5542" modified="2020-04-22" version="1">MPRKPAREGMPESEKIILPPKYYLDYFRDLLAFIQKGSSHLLSADDVIFIQLFEALSEDAQCLMVRMMNRKGAYFRLDKLAYEEIGSIPQAAEELVASGLASLDPPDDFLLFGLFTKAELHQLYPDRGFNKRRKEEVLEELAEENHPEDFQTLRSAYTILHFLAQEQVEYLKMLFFGHTHGMMTEFVIRDIGNIKLENLDDHEFTPWFETQAEARAVFELHGWNRLVKKAMHILLPEEILELIAPVNWSNFLQHPKARKIGDKFMLHLGEYFEKCGLLTEALDYYSLARKHPARERRIRILEKMDDLDAAREIAEVAFDSPYNASEKIFAQDYLSKKSKRNYRSTTAKANLSPEIIIENPEGPRVEAHALAYFAKQGYEGIHTENYLWRGLFGLFFWDELFAAEHASFHHPLQRMPSDLHSDTFYENRAPLLQEKVNAFRTKKKLQAYLAEVHRQKQHINNSLVGWHESLLPTVTACVHHLPLESLFNILMEMAKNVKDNSSGFPDLFIWTQEDYHFYEIKSPNDHLSAQQLFWIDFFNTHNIKADILRVKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G9</accession>
    <name>A0A654E0G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">xerD</name>
        <name evidence="10" type="synonym">xerC</name>
        <name evidence="14" type="ORF">MARINOS108_120327</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="110"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD16643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34644" checksum="57AAF7A9535F3E16" modified="2020-04-22" version="1">MVSWDVYIKQFRNYLKLERSLAGNSIEAYVRDITKLREFFEIKNLEVSPLKVSQANLVDFIEFLNELGMSPYTQARMLSGVKGFFRFLLYEQLIDKDPSELLESPKIGRKLPDTLEFHEIEALLAEIDLSTDGGTRNRAMLETLYSSGLRVTELIELRISNIYVEEGFVRVIGKGSKERLVPIGREALKYIRLYKDHVRVHLDIKKGHEDFLFLNMRGSHISRISVFTIIKDLALKAGINKSISPHTFRHSFATHLIEGGADLRAVQEMLGHESITTTEIYTHLDRDYLKQIINEFHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P8</accession>
    <name>A0A654E0P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="416" mass="47304" checksum="347DC8CD623DFF14" modified="2020-04-22" version="1">MDRKIQKKKWTLKRIATWGGASVFVIFILYSFIFADGGSRLNVEREKVNIATVMEGEFREFIPVDGSVMPIKTIRLDAIEGGVVEKKYYEGGILVDKGDTILKLSNNDLLQNFVREETQAFILMNSLENTKLSLKRNQFELKRNLIELDYQIDEAKDAYVRGQELYDEKIISEQEYLNLKRAYDRLIDSKVIQIESAKFDSLNARLQIAQAESTLNRTRDNLEMIKKNLDNLYFKAPISGSLSTVNAEVGESISPGQNIGQIDDLNGFKVRAAIDEHYIARIYQGLSGTFDFAGGSYTLQISKVYPEVANGLFSVDMVFTDTIPQGIRRGQTLQIRLQLSENITAVQIPRGSFYQTTGGNWIFVLTADESEAVRRQIRLGRQNPRYYEVIEGLQPGEKVVVSSYEGYDDKDKLVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S5</accession>
    <name>A0A654E0S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ORF">MARINOS108_120489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7354" checksum="AAD38AE6302FE12B" modified="2020-04-22" version="1">MKNSELRGLSLDELKNKLVAEKDNYGKLKFAHSITPIENPMKIRESRKLVARIQTEITAKEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T6</accession>
    <name>A0A654E0T6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="19405" checksum="DC1623CACC978F06" modified="2020-04-22" version="1">MTKRLAVFCGSSTGKNISYSQAASAVGKLMSEQGIGVVYGGGKIGLMGVVADAALAHGGEVIGVIPEKLMTREVGHTGLTELRVVATMHERKAIMAELSDGFIALPGGIGTIEEIIEVFTWHQIGYHNKRCGFLNTDGYYDKLFGFIDHMVEEGFLSAKQRNELTISEDPEELIRLMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U3</accession>
    <name>A0A654E0U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="36659" checksum="29D190689FE186F0" modified="2020-04-22" version="1">MQYRILGKTGLKISEISLGTWQVGGGWGGEFDEKAAERIISTAVENGVNFLDTADVYDDQQSERAVAGFVKENRDKLIIATKIGRRLNPHVADAYTPEAMEAFVDEALKNTGLQYLDLVQLHCPPTPVYQFDDVFARLEKIKASGRVRHFGVSVEKVKEARMAADYDVVESVQIIFNMFRQKPAEDCFKLLSERNIGIIARVPLASGLLSGKMSADREFDKNDHRAFNRNGEVFDKGETFSGVPLDQGLQAVSKLKSVFGQEALYQYALKWILQFPEVSTVIPGASRPEQVISNLKVGDLPALDDEQMTAVKDIYDEYIRPEVHHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E129</accession>
    <name>A0A654E129_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15547" checksum="56AD7FB7F92448A8" modified="2020-04-22" version="1">MGIVHLTPVCSSKGKEFKFLLTNFNVMKQFLYLFRGGDEEYARQSPEQMQAHMAKWGEWMLKISQNDQPVPGLPLQAEGKVVYNGGETITDGPFMEGKELVGGYVLVEANDLDHAVELSKDCPIFEFGGSLEVREAVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E178</accession>
    <name>A0A654E178_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="354" mass="37654" checksum="4051EA952E0FED59" modified="2020-04-22" version="1">MITQFLEASQNKWTKVLIGLAVVLVLCFLINVALGSVTIPFESLISFITSGSSGQASWDMILSNFRLPKAITAMLVGSALGVSGLQMQTLFRNPLAGPYILGISSGAGLGVAIAIFLGFYLGGFLELSGIGRSWLLVASAGAGSFLVLLIISLAATRLKDSITLLIIGLMFGAAAGALVSILQFFSQAENIQAYVIWSFGSLGSLSWSELYVFIPVILIGLIGSVLLSKPLNTLLLGENYAISLGLNIKKIRLLIIINTAILAGTVTAFCGPIAFFGVALPHLTRMLFNTSNHLLLTPLIILFGSALMLIFDFIAQLPGMEATLPINAVTALFGAPFVIYILLRKKNLNYAYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B7</accession>
    <name>A0A654E1B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025348">
        <property type="entry name" value="DUF4252"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14060">
        <property type="entry name" value="DUF4252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024995410" evidence="1">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="18961" checksum="FC4DD4117B71D2C6" modified="2020-04-22" version="1">MKKGLLIIILSVFSVSLMAQGTVVNKYFTELADDEAFTKVSVSSKMFSLFTDLETGSATEDEFLKAVSKLKGLKIIVADSIGNAAKMYNKVLIDIQNAGYEELMSVKDAEENMKFSIKEKAGKIEELLMVVGGKKRFVLLSLYGEIDLKSISKIAKSMKVDGLENLSKIDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C3</accession>
    <name>A0A654E1C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="24526" checksum="22A56B4943EA26BC" modified="2020-04-22" version="1">MAKKYTFTESEKQQVEQAVKELETVSCGEIVPYFVGSSDDYAEASWYVSTLLSGFTLVLVGVLSYTWMLPFRITPMEVAIVAFVALVIGFLFPLLFPQAKRWIIPKERQAQRVRQRALEAFLNEKVFETEERVGILIFVSRQEHMVLVLGDEGISRKVQTADWQTVVDEVVMGVKANQIGEGLVKAIGICKELLLKNGFVRKSTDTNELDDGLRIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C7</accession>
    <name>A0A654E1C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mdh</name>
        <name evidence="3" type="ORF">MARINOS108_120464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="360" mass="38388" checksum="7073205C58236E0F" modified="2020-04-22" version="1">MVVAHDSLFQFTKSILEAAGCPEKDARLGAQVLLSADLRGVDSHGVARLVGYVRLIDKNRVNTRPDVKIVHETPSTGVIDGDAGLGLVVGPEAMNLAIDKAKQVGSGWVAVRNSNHYGIAGYHAMLALKDDCIGIAMTNASPLVAPTFSKERLLGTNPIAVAIPADKEPPFVLDMATTTAANGKLEILQRKNKQAPTGWIQDASGQSTTDPNGVKDGGALLPLGGDREHGSHKGYGLSSVVDILSAVLSGANYGPWVPPFVAFMEPAADPVGKGIGHFFGAMRIDGFRPSGEFKSHMDNWIGRFRNAEPIMKGHDVLIPGDPERKLEHERRKDGIPLLDAVVNDLKGLSDRFGVEFPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D0</accession>
    <name>A0A654E1D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="39992" checksum="B3697F5D200A1C67" modified="2020-04-22" version="1">MNKRKIYWMCQVGGWSFYGFLQIFLYATVQQLDMTQILGEVVQVLFYIFSTHFLRYIVIHFGWLNDHWVKLIPRLLFVILILSLMNYGLLLTYSFISGELTGRDFLPFTILLNVFGPMIIYFIWAMIYFTFHYFERYNKGLKYEAAAKEIELRNLRSQLNPHFIFNALNSIRALVDENPVKSKNAITQLSNILRNSLTVDRQRLVTFSEEMEMVRDYLALETIRYEERLRIEFNIDPKSTEYLIPPLMVQTLVENGIKHGISTLKNGGKVEISSKVDNENLFIQIRNTGQYLNGETKKKSGFGLNNTKKRLELIYGDQASFRILNETKKIVLTEIVLPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J4</accession>
    <name>A0A654E1J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="32324" checksum="409968C485D6890B" modified="2020-04-22" version="1">MDLYTHTALQCSKVITRNYSTSFTLGIQTLHKKFHMPIYAIYGFVRYADEIVDTFHDFDKAQLLARFKMDTYQAIDEKISLNPVLHSFQLVVNQYHIGHDLIEAFLHSMEMDLQGESYNQAGYEEYIYGSAEVVGLMCLRVFCDGDGAEYDRLQPSAKHLGAAFQKVNFLRDIKSDFKERGRIYFPGVDFSNFSQEDKKKIETDIEQDFKAALIGIRQLPPPARAGVYLAYIYYLQLFKKIRKLSASRILSERIRVPDFQKMVLLSKTLLMHRLKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R6</accession>
    <name>A0A654E1R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FecR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="122"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="2">
        <location>
            <begin position="259"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="37139" checksum="ED920B214FECFE2A" modified="2020-04-22" version="1">MEHLISKYLINDLTREEEVKLKSWLEEDALNRKVFENIVADWKLSADEILTSKSAVLDRIVNSATPSHELPKERSLGAFDYLIRVAAVMVLGIGLYLVWDATNSAETSHVATQEVQIEKEAANGQKLTFELSDGTIVKLNSGSMLSYPKVFSESKREVTLVGEAFFDVARDESRPFKIKSGEVNVQVLGTSFNVRSYPDAEQIEVAVKTGSVSVESSFSESDVVLVPDEMVVYTTGSNFFDKKRIEDSQQVFGWMDQALIFEDRGIKDIIKELSRWYDVKFEIKRELDYKKAFTARYKNPTLKAVLESLSYAYDFEYEIDGKKVIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W4</accession>
    <name>A0A654E1W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="23369" checksum="8BE94621296D45CE" modified="2020-04-22" version="1">MPALSKKFLPHFLIILLHIVGVAGTLLPLTSELVVALTPVNLIVSTGILLACHPGALRSVLPPLLFCVLVGFGVEVLGVHTGFPFGRYAYGPVLGWKLLEVPLVIGVNWFLLIYAFFSIGNFFKKPAFRILFTALAMLLMDLLIEPVAIHLGYWSWAGGDIPIQNYLSWFVISLVMALVMHRHQPKLMNPVSVTLILSQILYFSAIFFTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E227</accession>
    <name>A0A654E227_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mutS</name>
        <name evidence="10" type="ORF">MARINOS108_140077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="9">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="619"/>
            <end position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="871" mass="99002" checksum="455AB3AAE2BF8CD6" modified="2020-04-22" version="1">MAKSAKPSETPLMKQYNAIKARYPGALLLFRVGDFYETFGEDAIKASKILEIVLTKRANGSASHIELAGFPHHSLDVYLPRLVRAGNRVAICDQLEDPKSVKGIVKRGVTELVTPGLSLNDNVLEQKRNNFLAAIHYGENTCGVSFLDLSTGEFLVAQGNPDYVEKLVQGFQPSEILFSKSERERFEKAFGKDYTNFHLEDWIFSEEYGYEKLTRHFNTANLKGYGVEEMRSGIIAAGAILFYLEETEHKEVKHIGQLSRIDEQQYVWLDKFTIRNLELIQPSQGDGTALIDILDNTQTPMGSRLLRKWMVLPLKNKEQIERRHLTVEAFMSEEETLNEVSGHLKQIGDLERLISKVATGRINPREMVQLKRSLSQVKPIKDRLKTSDSSIFKQYLDQLNDCEALLEHIEDSIKEDAPINPNQGNILKEGVNDELDELRKMAFSGKDYLKGIQERETERTGISSLKIAYNKVFGYYLEVTNSHKDKVPEEWIRKQTLVNAERYITEELKVYEEKILNAESQIFVIELRLYQELVSFAMEYIELIQQNARVIAALDCLTAFAFLAKRNNYVRPTMSEEFSLDIKAGRHPVIEQNMPPEEDYIPNDVFLDDESQQIMIITGPNMAGKSALLRQTALIVLMAQMGSFVPAGYARIGLVDKVFTRVGASDNLSRGESTFMVEMTETASILNNLSNRSLVLMDEIGRGTSTYDGISIAWSIVEFLHNHPQYKAKTLFATHYHELNELTNDLPRVKNFNVAVKELENKIIFIRKLQAGGSEHSFGIHVAQLAGMPNQVVIRANTILKHLEADKLSENEKEKLAEVPSSQFQLNLFESDPRFEKVMKMLREIDINTISPVEALLKVNEMKEQLKGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E257</accession>
    <name>A0A654E257_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="23864" checksum="E36702E6731EF5A5" modified="2020-04-22" version="1">MRPTKNTLILVFGFLCIYSCTPKKPVDREGFRQEKAARELKRIVPADLMLKGEELGEEILSATANAYLNTLKRAIVENGISGAIDFCQLSASGIAAGLQDSLGVTISRVTDKPRNPGNMLSESDKAIWEAYAYVPENLDGQIQEYDAESLIYTKPITIGSTLCLNCHGQVGSDITPENYSLIKSRYPNDEAVNYEVGNFRGMWRIIIPKKAIVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E293</accession>
    <name>A0A654E293_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="90" mass="10324" checksum="753E17FF79DDA814" modified="2020-04-22" version="1">MPLLAKDFVPEKSKGGMFKSGRIQSFQEVLEAANIWIKENPAIDVLNVETVVLPNIHESDEEGSMDTELWTGGESSSHWYQLLRVWYRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B4</accession>
    <name>A0A654E2B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="401" mass="45985" checksum="F91622E17A1179EA" modified="2020-04-22" version="1">MKILYIHQYFKTPAEGGCVRSYHLAKGLVDQGHEVTMVTTHNIWSGLHQIDGLQVHYLQVPYANRFGFMRRIWSYLSYVVLAKRKIARLKTKFDLAYVMTTPLTTGLIALHLKERYNLPYYFEVGDLWPEAPIKMGAIRNGLLKNLLYRFEKKCYFEAQKVIALSPAIRNYIEANSPETKVHVVPNFADVSFFEANHKIQRFTAENPLKVGYIGTFGAANHLDYLLDAARVCQEQKLPVVFNLMGDGAHLKRIKRLSRQLDNLTLHPFGSADSVKHLLESQDAVYVSFKNLEILNTGSPNKFFDGLAAGKLIMINFGGWIRQIVEEQKCGFYHDPLDPTELARKLSVFLKEPEMLYQYQKNARALAEKYYSKELQVQKLGKILTNQKHLSVSDSEVYILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B8</accession>
    <name>A0A654E2B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="75" mass="8250" checksum="BB0CD21B52B8E41D" modified="2020-04-22" version="1">MIADVLGYLALGLGIFAMANKHMLWLRIAHGLSAGCYLSYGLMISATPIVVAGILFLIIHSYHLTRMFLDRKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I5</accession>
    <name>A0A654E2I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="498"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="728" mass="81783" checksum="D5A08162221FF05A" modified="2020-04-22" version="1">MSYPIKLLLLIVLSITLQHSGFGQSQRIDSIKSTLHRETPADSTHIDLLLELAERYHQKRMPDSTLSYARWALSLAEKQGKYHQHIKALRLMGAAHIIKNDFIAAQASLEKIVPSKATSDKLTQAELANALNYKGIVAGYLGDFQTSISYYNQSLIIHKALKDSISIAGRFINLGNVYMRQGDYPAAIRSFFESFNYLSEDGGETQAILNLNLGECYELLEDYRKARQHALKALDGFENSTQSPVGISESHYTLGNVYSQIGNRDSCIFHIKKGISVALKTNDADRVAEGHHYLALHYKRNEEWNKVAENASIAYEYFRKVKSPRRYTAAQLVLSEAYLNLHDIKKSVSLAEKGLSLSRELELKDTEKDFLLLLSRLYASQKDFSKAYQLSLEYSAVKDSVLNQEKTRQIANIEALYENEKKEQQLALAVARQKAAQSSLEERKTRELFLIAGLMMTMVVLALGIFLYVTLRQNKKVVEDQNTRLQNLIRTKDRFFSIIGHDLRGPITSFAGINNLIKWYIEKKDEKKLRALGENISKSAEQLDTLLNNLLNWAMAQTGGLPYHPESFQLEPAIHEIEGLFTNQLKVKNIALTVKITEPTCVLADRNALLLVLRNLISNALKFTPMNGAILIGCQTENEQVLIQVRDSGVGIPKEKLETLFELNESKSTFGTANEKGTGLGLILCKEYVSLNKGTISVDSTPGHGTVFTFTLPISSMNEEPISSIHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I9</accession>
    <name>A0A654E2I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024986151" description="Peptidase_M28 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="259"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="485" mass="55099" checksum="D7697485C34894AE" modified="2020-04-22" version="1">MKHLLFGSILLLFFINANSQDKRAVKYSKTITTSDLKDYLSVLASDSLEGRETGERGQKMAAAYIAEKFNSFGLEAPVKTDDGMSYFQSYPLKKMTYRTAYLKKGEEVKTNFEDFIYNSREETIGEEYVDILFAGIQTIDNLKKMNLSGKFVAVVTQEMGNWRKVLAEVKDLDAAGIILIVEDESRFSFIMTRYSRYLQGSRMALESTTAGNKIIIGDPELASWMFDMPYDKLKETGKNKSARLILNADMLVEDITAENVLGFLKGSEKPEEVLVVTSHYDHIGISDNGEINNGADDDGSGTSTVLEIAQAFSEAAAKGIRPRRSILFMTVSGEEKGLLGSEYYTENPVFPMENTVTNLNVDMVGRVDEGHEKTPNYVYVIGADKLSKELHDISEKANNTYTKLELDYTYNAETDPNRYYYRSDHYNFAKKNVPIIFYFNGTHADYHRPTDTIEKINFELMQKRAELVFFTAWELANREDRVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N0</accession>
    <name>A0A654E2N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="20440" checksum="420D3BE8B9DF95F2" modified="2020-04-22" version="1">MKEIRRFLLILLGIVISLVAFTQDFKAITQKEMKKMSFMTGEWQGEGWVMTPEGMETSRVKETISYDLDNTVLRLRGVGTADKDGVEVKVHDALGVLYFDPFRQQFGMSSWISKGMHTDANVELLGEGRLKWWFEAGPAGTIRYTLKIENNVWVEIGEMSQDGETWRQFFEMKLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P5</accession>
    <name>A0A654E2P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046111">
        <property type="entry name" value="DUF6048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19515">
        <property type="entry name" value="DUF6048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="29284" checksum="CC614F795B96502F" modified="2020-04-22" version="1">MVERHRRNGGWSLAPTLKMVAVILGCTLFSVTTLFAQGPAGGQRPQPSGKTQKTNNQLPKEPRDFRPSMLKLSVDAVPVGISLFGANRSGSGYQALIDFDQFFFAAEYGTQKTSRGESYRYKNEGSYFSFGPEVNFLKNNAKGNSLTFGLRYGQAQFSDQLSYFKTGGFFGDLQVEDANPDLKARWMELTVGLNANVWSNLYLGYTIRYKVLRQVDNIGTMAPYDVPGFGLYEDNTGVQFNFYVGWAIPLREKYPDEAALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P7</accession>
    <name>A0A654E2P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic chaperone for outer membrane proteins Skp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024975844" evidence="4">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="20067" checksum="A72AD98A8362F95B" modified="2020-04-22" version="1">MKAKILSVIVVLMACAAQVSAQENLKIGYTNADYVLSLLPEAKQIDAELKAYEKQLQNQIQAKYNNLQTKMSDYQANAATWDDLIRTDKEEEIQSLQQSIQKFSQDAETSMGNKRNQLLKPVYEKIGNAIEQIAIENGYTHIFSAGAPGFDVLLYAREQDDVSNIILKKLGITPPAVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E365</accession>
    <name>A0A654E365_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">MARINOS108_110058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD15886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="27479" checksum="A4DCA84BF8EDDF71" modified="2020-04-22" version="1">MKQPLNVIKIGGAVIEDPEKQKAFLDGFVALKGPKILVHGGGRIATEIGERLGMEAIMVEGRRVTDDATVDLVTMVYGGLVNKQMTAKLQSLGVNAIGLTGADGSIIRSVKRPVTNGVDYGWVGDPVEVNADFLTKMIEVGGVPVIAPLTHDGAGHILNTNADTIAGTIALAMAEFFEVNLALTFELDGVLADVNDPESLINPFKESFFIEMKESGAIHSGMIPKLENSFKALHSGVKGVRICKYDQINSNHGSLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B7</accession>
    <name>A0A654E3B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="47633" checksum="F611A4344D8B80D9" modified="2020-04-22" version="1">MAYLFKQSIVLIPLTLFFVFLVLVLRLKYAIIIWLSSYHFDLVAMLDSSGIESISFNFLRLLVIPSVVYLRIVHAEKLTFHYNKSLIYAVSGVLVLTLSSSILSGLHIEAVKQYIYLLNFVISYFILQKVLSKDWLNNSYIYLIFFPLVFAILQTYFLGHYYGGVNNQRFTTFTSPQTYALYLVVLFILINDYSKRKGAKEYLFLIIILIQLLLTGSRYSLILFGATFILDFMTLKRLKLKISTLLIIVATVVGVLGIGSDAISKLRGLDFIASSNSASVTEIGTIKFRVAIWLFMFNDFMNSSVFYQAVGQGICSTGTLMIEMMPAYTEANMDYNRIAHNEFLRVIYEFGVIGIIVFVAFLWRLSSTIKSEFTLMLKFSIILIGALSIENIFAASGGPSGVALVLMYTGILNKIQVQEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B9</accession>
    <name>A0A654E3B9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ORF">MARINOS108_20074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="642" mass="69082" checksum="F8704CF2E70E5F0D" modified="2020-04-22" version="1">MGKIIGIDLGTTNSCVAVMEGNEPVVIQNSEGRRTTPSIVAFLDNGNGERKVGDPAKRQAITNPQNTISSVKRFMGKKYSEVTEERKNVSYGLEAGTNDTVRVKIGDRNYTPQELSAMILQKMKSTAEDFLGQEVTEAVITVPAYFNDAERQATKEAGQIAGLEVKRIINEPTAAALAYGLDKKNADMKIAVYDLGGGTFDISILELGDGVFEVKSTNGDVHLGGDDFDGVIINWLAEEFKKDEGLDLRKDPMALQRLKEAAEKAKIELSSSSSTEINLPYIMPVDGVPKHLVRTLSRSKFEQLSEDLVRRSMEPCKKALADSGLAASEIDEVILVGGSTRIPRIQEEVEKFFGRKPSKGVNPDEVVAIGAAIQGGVLTGEVKDVLLLDVTPLSLGIETMGGVMTKLIESNTTIPSKKSETFSTAADNQPSVEIHVLQGERPMAKDNRTIGRFHLDGIPPAPRGVPQIEVTFDIDANGILQVSAKDKGTNKEQKIRIEASSGLTDEEIEKMKQEAQANAESDKAEKEKVEKVNQADSLIFQTESQLKEYGEKLSEGNKTAIEGALAKLKEAHASRDIAAIDAGMEALNAAWQAASQEIYAAQQAAGGAEAAQGADPTGGADAGNADSDVSDVEFEEVDEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D4</accession>
    <name>A0A654E3D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="12474" checksum="D02CD3888E8B61F5" modified="2020-04-22" version="1">MGKHQLGEFEEVVLLTVAILQGDAYGIAIIEEMETRLDRKVSIGALQTVLRRLEKKGYLKSEFGEATAVRGGKRKRFFSLTQHGRMILHETKEQRLGLWNAIPDFSLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D9</accession>
    <name>A0A654E3D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="13235" checksum="BBDED5DE521058CA" modified="2020-04-22" version="1">MKETIGEYIHKLRIESGMTLTKLAAALDIDQSTLSKIENGKRNIPRFILPKLAETFKLDIKRLEKEFFSEMVAEIIYSQEEPQEVLKLAEEKAKYFKTKKEHQGSLSFEKGKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H5</accession>
    <name>A0A654E3H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="401" mass="45297" checksum="EA03255BF0CD4918" modified="2020-04-22" version="1">MISKFINFFIPRQRQENAEEHRQYKLVTYFVIVTFLFDLNYISLSSTIGFEMGMRIMAITAGAHLLQAFAIRLDWPLWLVSNLYVLFGVFGVVGCTYYSGGFYSPVIVWLASSPIVALLMAGKRSGFVWMFINAAMVVVFALMAKNGYEFPVDYDAEWSNFFIANTFFGLVIIIFVVALVFENGKNTALRKLAQKNILLAEEKKKTALYALSQEIHDNVGQTLFLAKLNLSTFDLVPDDERERVKNSMELLSQAIDKLRDISSTLNEENITNFSLLNSLKVDMETISGIGALKTKLEVQGEVQKLNSKTEFVLYRIAQEVINNVIKHSQAAHLHVKLIFSSNLLTMYFKDDGVGMNSEQLLKDGQGMRNMRERTASIQGEINFSSSENCGVEVTVKAPFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K6</accession>
    <name>A0A654E3K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024788513" evidence="1">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="18847" checksum="8F282F05AB1CB767" modified="2020-04-22" version="1">MKALLPLLCLTMLSACLTNPSRTENTYYQNAKLIEEHPYVLPGDSLVFLRYHQAEDKENVMDDEYAEALYFQIPNTTQFHYEGADQLRQLKIRLYPYCFCMEAVGNTIEGGKISGTRSNGNWRISADIDLRIIYAYDQDSTYLGQRINRTFSGTFHQEAIPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M8</accession>
    <name>A0A654E3M8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">panC</name>
        <name evidence="6" type="ORF">MARINOS108_20805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="31617" checksum="34FDD61F67ADC8A7" modified="2020-04-22" version="1">MEVIKHPNDIFRYTEDLKSNGKKIGLVPTMGALHQGHFSLVRQARASNDFLVVSIFVNPLQFNNSQDLTNYPRTLSDDLGQLEKLGVDLVYTPEVEHMYPTSPEVQVDFGRMAHVMEGAFRPGHFSGVGVVVSKLFHHTNAHRAYFGLKDLQQFLLIRRMVADLSFPVEVIGLPIVREPSGLAMSSRNKRLTPEGLEIASKLHEGLVMGKSLWEQGRSPNETKTAINDFYKGQTGLEAEYVELVDPDDLSEITENHSQPVALCVAGYVEGIRLIDNLYLRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N5</accession>
    <name>A0A654E3N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22979" checksum="A153E2A4EA0FC306" modified="2020-04-22" version="1">MKPTPEELDILNDQNFLKLKNSLSEKIIQYLAKIERALADEIKEMPFQFPVGTFLKAGKISKGEQYQGLPYFILDYPRLFTQKEVFAFRAMLWWGHHFSCTLHLQGDFLQQNKSRIIDNILAQNALYFCVNDQPWDYHYQENNYQQISTLTRATVSQHIEEKGFIKISDCLPVTAWSEYESFALNSFARFLNYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N6</accession>
    <name>A0A654E3N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11695.1"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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    </dbReference>
    <dbReference type="InterPro" id="IPR025519">
        <property type="entry name" value="DUF4407"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14362">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="350" mass="39098" checksum="3C662B23D9CA827F" modified="2020-04-22" version="1">MNRLKVFFWLCAGANREILSNCPSESSKYVGIGATIFFTGIFAALAGGYALFTVFDSYWLAAGFGILWGLMIFNLDRFIVSSMRKNGQPQQEWLQVLPRLVLALVISIVIAKPLELKIFEKEVDSEITSMMQEDLALKELTVKERFSATRARLSAEVQSLKDEILAKTASRNELRQIAREEADGTGGTQQRNAGPIYQIKKADADRVDAELQALIATNTPQIAEKEQAITELNTREQTELSATEAGQLTGLASRIEALDRLTTKSSAINVANWFVMLLFLVVETAPIFVKLISQRGPYDYVLKTEEYGFEAFHYEDLAKVNATIKNRSSKLTSEEAEYVNSRLQLGLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q7</accession>
    <name>A0A654E3Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
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    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="31474" checksum="7A2D097BBE6318DD" modified="2020-04-22" version="1">MKLKISHRTLYEYSNLVFAEPHHLYFYPSQRNYFKLRDFRIHVDPAPSGLAFRLDAENNPFHQCWFNFQIEKLEISIEMEVETSALNPFDFLVEEDPHKDHQTALQLYLGKVDLNPELVAWITEIRELSGGNMVTFLSYLVKEINADWEHNERYAENVLPPNVCFEQRSGSCRDLSWMMIQMLRQLNIPARFVSGYAFNPGLKEGHELHAWVEAWVPGGGWIGLDPSAGLLAMENYIPACSSYKPENTLPVQGSYRGDSKANLTFEVRIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W9</accession>
    <name>A0A654E3W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="325" mass="37602" checksum="337E010C3D016D54" modified="2020-04-22" version="1">MANPKQSTIKRLFAVSSNECAFPKCTTSIIDQVSGKVLGEICHIKAQNSDGPRFDESQSDPDRHAFENLILLCPTHHTVIDSDIQSYSVERLIKMKSEHEGKAEKEYEYPDFLIQQLIDKLNITTKIFSNSNVVEGNQYAEVIQNITNPIEIKNRLSYNEILPHLHEENTPLSKVISEILNASHESKDQELIELCQEELTGWPNPPQTENHHRIIEVFISVNKIQKVWGLTNDELWKEFESKDDFVKMNMFYGESVPRLEQMINANKYNDPNSSYIHLEQKQGNLFPHLPHPEITVHIYAKGTMVHELLNRIRNTFSEKLIQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E400</accession>
    <name>A0A654E400_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PTHR23222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="274" mass="30677" checksum="79AEC3C939160902" modified="2020-04-22" version="1">MDNRKYLPLIIITAIVLIVLLTISNSIIYKVKSGERAVIFNTLTGELDKSNVIGPGFHGKVPWSDAYIYDVTENQIEETMDVLDKNGLNINVDITVRFHPVYDSIGEIYETFRLDYIRRLVIPEVRSTVRQVMGRYTAEEIYSTKRPEVEGSIKTETDAILGAPGNNIEMRALLIRSIKLPEQIRLAIENKLTQEQEALAYQFRLDKEKSEAERKRIAAEGEAVANKIINSSLTDELLKMRGIEATIDISTSPNSKVIVIGSGKEGLPLILGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E425</accession>
    <name>A0A654E425_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="575" mass="64606" checksum="8FD0CA523E2C4193" modified="2020-04-22" version="1">MRFFIYSIVFLTGAVCLAQNRPTHFTDSTGALYWRKSTPVYLFVSDAPDGDKERLKSKATAQYADPFYLDTEGVNYIRSRNAVDPETKRVIPDSEVMFEIYADGIAPVTSVSYENVNKFQGDLLYYKAGVSVSLEAKDQLSGVRKLEYAINDGKYTPYQKPLTFQDPGIYEVEYYSEDEVGNVEGKKSISFVVDPTPPYSDLTINGITEDEVISTGSKLYILALDSISGVASVYYKFDDQPFKKYNGLQLPTAQLEEGEHTITYYAEDKVKNVEEHKSFTFFLDKSAPLMVADVLGDRFIVMDEVYFSGRTKLKLTAVDNKVGVKEVMYSVDNEEFKKYEKPFYLPSVSGVHLIKYYSVDNLDNSTADSKNSRYIGQGGFEEFKHNVNKFYVDLTGPVINHSIGNYTFTRSDTLFIGPYSKIKLTGTDPESGFKSIAYSLGGDVGEELYTEPFTLTREGFNTLNYYGYDNVNNRNIAKFTFYLDATAPNIFIQFNTGNTDSREGKLVYPITSGIFLSATDKTSGVNSVTYSLDDAPFKSYAGLISGMKKGKHTLVVKAKDFLNNEAVKEVTFHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E479</accession>
    <name>A0A654E479_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21625" checksum="6522251541D930D6" modified="2020-04-22" version="1">MFASSIPKEDIKHLPLIKFEGTIHTVETMEALDEALKIIRTQEIMGFDTETKPTFTKGDYNHTAIIQLSTMTDAFIIRISEIGIPDQLKDILEDQGILKVGISIRDDIKELKAMRAFKAGGFLDLNEVAKELGITQIGMKSLTGIFLKARISKSQQTSNWETKELSPGQLSYAATDAWVCIKIYRMLMDKGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M4</accession>
    <name>A0A654E4M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024974105" evidence="1">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23716" checksum="2FDCC14A063F659D" modified="2020-04-22" version="1">MLKYFIYIFSFFLTVSALVAQSDTPVKRNIIQFTGVVFAPDSNSVIPGVHVYVPTAGRGTTTNPYGFFSLPVLEGDSLVFSAVGFKRQFYIVPEHKESTSLKVLITMQEDVTLLSEVEVFPYPTEAMFKEAILSLETPYQKQYNNLNAWLSSDYMSSAYADLPASPNANHQYYMQMQMQAIQNKYQTPQNNLLNPWAWSKFINSLKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R0</accession>
    <name>A0A654E4R0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">uxaC</name>
        <name evidence="7" type="ORF">MARINOS108_90013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="53272" checksum="E4EA66A01BD7E002" modified="2020-04-22" version="1">MKEFLGEDFLLETKTAQTLYHDYAAQMPIIDYHCHLSPKDIAEDRIFNNITEAWLEGDHYKWRAMRTNGVDESFVTGNKSPEEKFEQWAATVPDTLRNPLYHWTHLELQRYFGIKDILKPASGKQIYQEASSKLNTPEFSVRSLMAKMNVTVVCTTDDPISNLEYHLQLQQEGFPIKVLPTFRPDNLYAVENPKAYKSYLRKLEELVGFGIASFEDLLKASQQRIDFFHEVGGRLSDHGLEQLYELGAADPSELFELILKGDTLSGYQVQQFKMALLVELSKMYHAKGWTQQFHLGAIRNNNTRMMRTLGPDTGFDSIGDFSQVKAISRFLDRLDNTDQLAKTILYNLNPADNEAMATMIGNFNDGSVAGKLQYGSGWWFLDQKDGMERQINALSNMGLLSRFVGMLTDSRSFLSFPRHEYFRRILCNMIGKDVENGELPGDMEWLGAQVQNICYHNAKNYFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y1</accession>
    <name>A0A654E4Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase/acyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_60059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="36818" checksum="B854ABC9CE331AAA" modified="2020-04-22" version="1">MSLLKVLSIDGGGIRGIVPGTIMVEAEREFGIKVADYFDLIAGTSTGGILTCAYLCPSDTDATKPKFTAEEVVGLYFNKGKQIFDDPFMHKLRSIWGIISAKFPERGIDEALKEYFGEVWLSQLLKPTVITSYDITNRNGHFFAQHDAKEKEAYDFLIREVSRATSAAPTYFNCAHVKNKLGDSFTLVDGGVFVNNPAMCAYAEIRDGFKNVDGAPAAAKDMKILSMGTGFTKKHYLYRQARKWGMAQWVRPVIDIMMSGSVEVDDFYLKRIFETTENPAQYMRINSKMPGDVDPEMDNVTPANMAALKKLGEKLFQDNKEALAKWFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E502</accession>
    <name>A0A654E502_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7638" checksum="FAC60B01DFF15B6C" modified="2020-04-22" version="1">MLEYFKTILAKVSFDRWLFEKELKKAIRSLVPEEIITLRDWCYDQFGQIYESILNKCFTKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E519</accession>
    <name>A0A654E519_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi phosphoprotein 3 GPP34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23316" checksum="BE0EAF67F7074EC2" modified="2020-04-22" version="1">MKISIAEGLYLIALDDEEGRLLAAAEKTIVPGLISAAILELHLLKKVGLKDNKISSVEQSGTGNGILDGILRKLKTGLNFLDAVEDLSHHFKDIQEDLNQLLVQRGILKKEATKLMWIPLSERMDNANYSFEQDIRNSLKTIVFKSAKPTISFVILMSLIYDCQILSEVFRDKDELIDAVKVAKDMVDSPVLTPEVSTALKELKKYFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E537</accession>
    <name>A0A654E537_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MetA-pathway of phenol degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025029417" evidence="1">
        <location>
            <begin position="25"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="381" mass="41765" checksum="08DC993DC0B3F1A7" modified="2020-04-22" version="1">MKNSYLTIAGILCLYLLSYNQIHAQGCVAIRSGCGANVGGGASLQKGQWQAGTNFRYFHSYKHFRGKHEETNRVKEGSEVINDSFFLDFLMSYGLTDRLSLNVALPFVHHNRSSLYEHGGNPKEDDISTVENEFWAGDRHATSSAGLADIRLGMTYWLLDPAESTGTNASIGLGMKFASGDYRAQDEFYNQGDNKDQTILSGVDQSIQPGDGGYGVTLDVQGYHTLSNGVVISANLYYLSNPREYYTLETRGRSRDFSVPDQYAARLGALVMTPIHGLFFYGGGRLEGVPSSDLIGGDEGFRRPGYAISLEPGLTYGIRNTAFNLTVPVAVERNRTRSFSDKESGGHGDAAFADYLINFSFSYRFGKSTPVLESIQSPTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E568</accession>
    <name>A0A654E568_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative enzyme</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_60159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="58"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="36464" checksum="46E464C68AC113F7" modified="2020-04-22" version="1">MSKKKYDVYAIGNAVVDYVLECSDDFLTEHGIEKSVMTLVDEERQMKVLAAVKDGIKKKEGGGSAANTIVATSMLGGKSFYSCKVANDEDGRFFLDELANNGIDTNLDGSHLDAGITGKVLIMTTPDTERTMNTFLGISSAFSKAELRQDALINSEYLFIEGYLVASETGREAMKVAKRMAEDNGVKVSITFSDPSMVKYFQKEMEEVVGASVDLLFCNEEEAMLFTKTDNVADAREELRKVARKFVITQGKNGAMIFDGDTFVDIESYPVSAVDSNGAGDMFSGAFLYGITNGHTMASSGKLASKAASEVVAKYGPRLTFHQLQEIKREVFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I3</accession>
    <name>A0A654E5I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021218">
        <property type="entry name" value="DUF2784"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10861">
        <property type="entry name" value="DUF2784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="14683" checksum="3038AA540475E8B0" modified="2020-04-22" version="1">MLQFLDAFLTIFHSAFVLFVLFGWAHPKTQKAHITALLLTFLAWMLLGLYKGVIGYCPLTDWHWDVKRALGETGMSGSFVGYMIEHYLGLSFSRSFYDAITAGGLILGSLMSFLVHRKNRNSKSEASSQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5J5</accession>
    <name>A0A654E5J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyl-alpha-D-glucosaminyl L-malate synthase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bshA</name>
        <name evidence="3" type="ORF">MARINOS108_60086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023881">
        <property type="entry name" value="Thiol_BshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03999">
        <property type="entry name" value="thiol_BshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="382" mass="42783" checksum="9EEE909C78E39271" modified="2020-04-22" version="1">MKIGIVCYPTYGGSGVVATELGKALAKEGHEIHFITYSQPTRLDFFSENLYYHEVSVKSYPLFDYPPYELALASKMVDVVEHEKIDILHVHYAIPHASAAYMAKQILKTKGIVIPVITTLHGTDITLVGKDATYEPVVTFSINQSDGVTAVSEDLRKDTLEHFDITREIAVIPNFIDLERFKKQKKDHFKKAICPLDEKLIVHTSNFRKVKRVQDVIDVFNRVRKVIPSKLLMVGDGPERHTMEELCRSMCNIDDVRFLGKLEAVEEVLSVSDLFLMTSEKESFGLAALEAMACQVPVISTNAGGLPELNLHGTSGFVCEVGDTKTMAEHAIHILDDANLGKFKEGALNRAKDFDVTNILPLYERFYVQTMENTKNSVSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5K3</accession>
    <name>A0A654E5K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="91" mass="10719" checksum="637FC0A7D5264E67" modified="2020-04-22" version="1">MKKDIISQSMYFAKKCPYNYESLIFKPIRMRYIMNMLLSRAAGEWFYTFYQPKNDTYAKKQTNSNPLRLVAIQSGGNCAADHQWYCEGPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5K8</accession>
    <name>A0A654E5K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041607">
        <property type="entry name" value="HU-HIG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005902">
        <property type="entry name" value="HU_DNA-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18291">
        <property type="entry name" value="HU-HIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01201">
        <property type="entry name" value="HU_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HU-HIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="13586" checksum="723B0100F4D28B5E" modified="2020-04-22" version="1">MAIKFNVIERGEPGVTGGGTKKFYANTITAGEKDIDQLTKSIEKISTVSGADIRAVLYALVEVAADELSNGNIVRLGDLGNMRVSISSSGYATADEVKSTAIKSNKVIFTPGKKLKEMQKLITYQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5S5</accession>
    <name>A0A654E5S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="21938" checksum="65C5851813C27743" modified="2020-04-22" version="1">MLTEVRRKKLSYLFNILDSNKNELLQPDDFSQVAEKMSDSLNFEENSKERLRLKLKSLRLYVQLLTDMEKEDVSITRDEWLGLFGSRNTISPKAAKKYIFRTAAYIFTLFDQNEDHIISKKEYYDMFKIYDIDMKYSEMGFEKLDQNHDGQITLSEMVNGFRDFLMSSNPEASGNWIFGDWQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E607</accession>
    <name>A0A654E607_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024988322" evidence="5">
        <location>
            <begin position="24"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="364"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="518" mass="57387" checksum="59F000E94ECB16D7" modified="2020-04-22" version="1">MMKSYHKISILALLTIMMSGCLGDLEVEPIDSNLITSANVYKTTADYKKGLAKLYATFALSGQQGPAGQPDIAGIDEGFGNYLRQYWNCQELTTEEAVISWNDATIKDFHAQTWSPTDVFIGAIYSRIMYTVALSNEFIRATDGNSDPDISKFHAEARFLRALAYSHAIDMFGNPSFVTEADLPGAFFPEQISRADLFAYVESELIAIESDLGAPKFEYGRADKAAAWMLLAKLYLNAEVYIGQPKYTEAIAVLDKVLAGPYSISTEYLQNFVADNNTSPELIFPITYDGNNTQSFGGMVYLIHAQIGGTMSASEMFGTGDAWAGLRTTSALVNKFDLDNDTRALFWTDGQSLEINDIGVFSDGYAITKFRNRKLDGSLSESNHNVHVDTDWPMFRLADANLMYAEAVLRGGTGGSRAEALSLVNELRERAYGDASGNITDAELTLDFILDERARELFWEGHRRTDLVRFGVFTGGSYLWPWKGNVKEGRATETHRDLFPIPSAELGANPNLEQNDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E658</accession>
    <name>A0A654E658_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="339" mass="37157" checksum="81DC1510BB4A0044" modified="2020-04-22" version="1">MDALITMARIPDGNPYKILGAAKMENCFSCICQGLGLILTGMPENHSSLNITVRHYLRQAFLIFIGVMCAVFGLESFLLPNDVLDGGVTGISLLLAIVTDGRPSLFIFLINIPFLALGWIQIGRGFAIKSFASISLLALILYFFDFPVITDDPLLIAIFGGFFLGLGIGFSIRGGAIIDGTEVLAIYLGKKIGFSVGELILIFNIVIFSVAAYLLSMDTALYSIITYFAASRTVDFVLEGFDEYIGVTIISDQHAEVREMILTKLRRGATIYHGSKGFSLQQKEEAKTNILYTVITRLEVSKLEGEIEKIDPGAFLVMSKVKDIRGGMIKKLPLKKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6C7</accession>
    <name>A0A654E6C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="23466" checksum="09A638FBC9F9C4BA" modified="2020-04-22" version="1">MHKTKLTDGQLLSQYKNGNEEAFAVLLERHKDRVFTTIYLIVKDRYQAEDLMQDAFIKAIKTIKAGKYNEEGKFLPWMLRIAHNLAIDHFRKAKRNPEIVMEDGSNVFNTLDFSEASIEDEHIKRDTYNLLKQYIQELPDAQKEVLVMRHYMQMSFQEIADTTGVSINTALGRMRYALINLRKKLQHTNIAYDQNFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8U4</accession>
    <name>A0A654E8U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_110097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="800"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="96"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="401"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="471"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD15936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="880" mass="99676" checksum="915A90D11EB4265B" modified="2020-04-22" version="1">MSRQETPPKWLDRLLGWYCRPDLLEDLQGDLHEYYHRNLSRGRFRANFIYVIDVLKFFRPYTIKKNQTLHSFNPFFMLGNYFKTSVRSLARNKVFSAINIVGLAISMSVGILMITYINELLSFDKFHQNGNRIYRILTTYKGITNNESVDLASTSIFIGRRLQEDYTGIEQLTILRRNFSADLKTSEKIISAEGLWASENFFDVFDFELVAGNPATVLHDPKSIVITESLSKKLFEEGEPIGQIIELVGQERYGFQSGTITGVVKDPPASSHMQFEMLGSLSTLEHYAAGQEGESFLTSYNSVWMNYVYVLLPENQRVDVIKKHLDQIAAEEGEKYDRFFISYELQNLLKIVPGRDLSNQIGPTVRWNMIYLLVGLTLIVILSACFNYTNLSIARSLRRAKEVGIRKVVGAGRAHILTQFVFEAILVAVVALMMGYGLFLLIKQEFIHLFFQNQEITLDFQWIHLVYFMAFALVIGVAAGILPSVFLSGLKALKVFKDPGSMKLFGGVSLRRMLIVFQFTLSIGFIIGATISYKQYQFAVNFDLGFETKNILNIELQGNDANILISEFLKIPEVEGISMSGMLPATGEVWGDEAKYKDPMDSVNIHVNYVSKDYLGLHQFEFLAGGTFPHDLKKDEDPKFTIINERLMRRFGMESPQEALGEVLTVDGSKKVQIVGVVKDFQHQRITEGHEPFAFLQGYEDYQVLNLKVASGDMVGFMTKLEAVWKAVDAVHPFRAEFYDDKIQKAYTQYQTYFKVIGFLAFLAISIAALGLLGMAIFTTETRMKEISIRKVLGATEQHLIYILSRGFVVMLVVASLIAVPTTYLLFEHMVLNDLANRIVVGPLELLSGVAVIFAVSMLTIGWQTARAARTNPAEMLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E950</accession>
    <name>A0A654E950_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_50096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="487"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="680" mass="76971" checksum="669BDAEDBF3A95F8" modified="2020-04-22" version="1">MMTPDRRSDGFCVRSGILMPQYVIFRLMSSLRKKLIPIFVLVICLASVGIVQSQPSEKQFDFDSLEQLVSSSPDTVGIKMLFDATYALRKNFPDSALSYGQRALERSKIIGFDRGIAESYNNLGAVFIIRSEYDTAVSLHRKSIEYYQKLGDEKGRATALNNIGHIEQERGNYEAAAEVLLESIQLNEQIGNDKILGSNYINLGLVMSNLGQADEAISYYQKAIPLKEASEDFESLGNIYNNLGIEFRVRDQLDSAEYFYRKAIHYRINARDYYALAGSYNNLGILYYYLDKPDSTAKLFHNALQTYQAVDDKKEIARSYFNIAELHRMQGRFEPSITNLELALASAKQAKSKEQFRDIYKGLSRVNASNGNYEKAYEHRLSYENYEDSLRSDRTNRMVTEMSTKYQTAEKDREIAALNLDQQTAALALANSQNQRNIFISGFIIFFIAAGFLLYRYNTKRKTSNLLTEKNQQISLALEERETLLKEIHHRVKNNLQVISSLLNLQAGSLKDEAAVDAVKEGQNRVKSMALIHQKLYSAEDIRGVDVQDYLENLTSELFSAFGVQGAGFEIDASGIKLDIDTVIPLGLIINELITNTIKYAFVTSHEGLLEIQIREEGDKLNVMVRDNGAGMDAEALEKSNSFGWKMIRSLSRKVKAEINILNDQGTTVQMTLSRYKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E954</accession>
    <name>A0A654E954_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="2001"/>
            <end position="2072"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2078" mass="214475" checksum="F889BC9768D438BD" modified="2020-04-22" version="1">MRFSFHYPVQYFTLVTLCLIPFLGLSQSTSWTGLTDTKWRTSTNWTNGVPDETTDVIIGDVNFIGLNQPTVAKGKGTGACKSLTVGNGAKTCELTIKDGFDIAGDLIIGSNGTIEDDGGRLSIVGDWTNSGSYTATGSNRRIYFAGTTQTIGGSSVTNFEKLYINAGSSVTLAQNIINSSFIDLSGTFNPTENYAVSGTGSIKIKAGGVLKVMASTFATNYTNSGGTNPSKSTSLIDYTSSSVNQTIDNSINYRILQISGGMTKTLSGNTTIQNDLLINGGTLDVSTFSADRNSAGGSLVIAGGASLKIGGTNTFPADYTSHTLATTSTVEYYGANQTVTSEAYGNLTLSSSSGSVVKTLPGTTLNIAGNFTASASAGTLGFTALNTMTIAGNVSLSASSTFEGSTFTHSLSGNWTNNGTFNGCGGTLNFNGASATMSGSGTNNFGNLVINGSGTVLHQNSSLSLCGNFSTVNGGSFVHTAGGTGNITTTGTSKTISGSNITLNNLIISTGSISTTSTLTLAGDLTVNGPLSASAGNITFSGTGKTISGSSTIQLAGVEVTGSLSTARDLLVSSNLSVPGSFTATAGQVTFNGTSTFSGTANIYDLLITTTGSLEMGSNSVLGIAGTTTLDAGGTFDAATNVPNTIEYNGSIAQSTVFPTFHNLILSGGNTKTPSSALTINGDFTLGGSTTFEAGAFTHSIGGNWTNSGTFTANTSTITLNGSNDSQLTGATTFNDLTVNKTNNSVITLNNSINAVNLTMTSGDILTGANSVTLTGNRTGAGLVTGTITRNLTYATSTDYAFEGPHSFINFSSITGSITSITMTSTIGPNSTFASAASINRTYDISVTGSTTYNATLSLHYEQAELNGNVEGAMTFWNDGGTATWVDATNLNTTFDNTDNWVAKSGLTDLLNKWTISEGLVIYSWDGSVDTSWSTADNWTPSGIPGIQDVVHIGDLIFTNQPTISTSENIKKIYFNSTTPGTLTMAAGATLIVQGNIDGIWSIDANHTINVGAQTLTTLSDIVLSNGIANREIDLNISTGTVNISGSLTQSEANITFTDAGNINIDGDFNYVSGTFTPGTSTVTFSGSGFQEIGGVTYNDLVIDKPSGTATISTAVTVNNNLTLTDASHLDLEGTLSVVGNIDIGVGTILNVPASSTINLGGNWVLSGSFVPGSGTVNFNGSGAQSVVATTFNDLSVNKASGTLTLLDDLIINGDVSIQNGAVEVSTYDVSRSTEGGTVSLGAGASARFGGTSLQINNFSNLITDPTSTIEFYTTSSRIIPPVSYGNLTITGGGSNAKIMVGPTSVSGTLTVSSGSTLTAPSTTLTLGGDFVMDGTFNASGGTLILNGTGNTIDGDITYDDIVVNGSYDLASGSATINGNLEVSSTGDFDAGVIPIVSYGDFTNSGIVISDGTVTFAGTQTQTLRLLSAITSSSTGIINFNGSFPQVFNSTSSPQFATVNINNTAPIVASQPWTVVVEMNVAAAASWDGGPLDHTFYGNFTNNGTVSSDGKLTFNPSSPVNINLGTNFTTTKEVEFGGTGLITLTDSNPMFESVTVSNSHAAGLSPLTNWTIAQDLLIKSGAQLNGGALSHAVSGSWTNNGTFNGETSTVTFDSSGGTDAINGSGANNFNNLIFATGTTMDVLADVNITADFTNNGTLVSLIDQLVKFEGSGASILGGTATTIFDGLEIDKSANDVQMTVDAEIAGDLILTNGPLDLNGNTLSVSNTLSTAVSRTNGYVLSENTSFNSVMAWTIGNNVATYNFPFGNASGDYIPFVFDLNSGDAGVVSLATYPTSSGNLPLPPGVDHVNTDGGTDNSENTVDRFYLINLTGATSPNADITFNASAAEVGTISDLLAQRWNGDWEAPKAGQTSGATSVTVPGVTEFSPWAISGNSVPLPVELISFKGQQQGSNAILQWATATERDNDYFEVLKSSDGQSFTPIAKVQGTGNSSTLQEYSLVDQSPAPGVSYYQLRQVDYDGAFSMSKVVSVRMIDPDWDISVYPNPASDFIHLVSNDDYSNEVSLVLYDQQGRVKMEKVLSEVHANQVFEMDIQALSSGLYIMKVYGPTFTKILKVYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9M2</accession>
    <name>A0A654E9M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lytic transglycosylase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_60134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="58"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="503" mass="57793" checksum="4D4739C109E9D41E" modified="2020-04-22" version="1">MKRNQIHKIGFLVTGLVFWLLMTACTTSSSSKKEKDPNSEPPEKVVDLDLDKIKERGYITAIMDNSSTGLFIYRGNTMGYEYELLKAFAKSQGLELRINVTPSLEEGFRKLNAGEGDVLAYNLTVTKDRKKRIAFTHYHNLVKMVLIQRKPDNWRKMKLHEIEKQLIRNPVELIGKEVVVRHHSSYFDRLQNLSNEIGDDIIIIEDSPEVETEAIIRKVAEGEIDFTVAEEDIALVNSTYYPNLDIRTAVSFPTQIAWGVRKNGDQLLSALNAWIIEMRRTSEYYTIYNKYFKSRKASLKRTQSEYYSLGGGKLSPYDSLIKRSAAELEWDWRLLAAQIYKESRFDPNAESWAGAVGLLQLLPTTAEEYNVTMLEDPVQNLYAGTQHIKWLQSYFSDVIIDPLERVKFILAAYNVGHGHVMDAIRLTEKYDGNPQLWEDVKEYLLKKSNSNYFNDPVVQFGYCRGIEPVTYVTTILSIFKNYKILFPEGPEVKAESPVLSENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBB1</accession>
    <name>A0A654EBB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="17076" checksum="452EDBB11A72DD77" modified="2020-04-22" version="1">MEWITVIGLILFGIGLLIIEVIFIPGTTIVGIAGFICSGFGVYLGYDYFGSATGTTILIVSSGFLLVVMIYAFKSRAWERFSLKDENTGRFNDDFKVTLSVGDQGQTISSLKPSGKALFNEKELEVRSNGGFINENQQIKIIRIEPNKIIVEPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDI0</accession>
    <name>A0A654EDI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence ComEA-like helix-hairpin-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="303" mass="34427" checksum="83EFEDD34A498521" modified="2020-04-22" version="1">MIRFIRQWIIDTLGFSKSEANGTLVLILVTFLAAVLPKIYLIESRSDKESFTADQESLRQWGEELESFLELKEFKSPEITSPIVEPKSFPFDPNTASLQDLISLGFSEKASTNLINYREHGGSFKVKSDLSKIYGISEERVQALWSKIQLPEVIAPKESKIVPVEKVTESKKRFDINRATAADLQTVRGIGPVLSERIVTFRDKLGGFHSNDQLREVYGLDPEVINKLSHLAIFTGEVRKININTDSLKHLYTHPYIDYNLARAIVSFRKQQGHLDSVSQIKPIKILSDSLYQKIYPYLSPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFH1</accession>
    <name>A0A654EFH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative outer membrane starch-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="99"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="266"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="554" mass="62468" checksum="C619AA4EEEBA3B32" modified="2020-04-22" version="1">MKKIFIAISIVAVLLPACKDQVLDQVPQGALAEGVEVDEGIMENLITAAYSSLTARFIGLHHVTFQGPTTNWIADIRSDDAYKGGGGIVDQVPMHQAETYVLNPTNDLAFNKWLNLTWAIARVNVAISNLLEYENPNYPSEIRMAEMRFLRAHFHFDMVRNYNQVPWLDENVLGSEASNTTYTKEELLELIEADMQFAYDHLPLSQPELGRVNKYTAAAYMCKILVEEKKWSEVIPFADEVIGSGQYALLNEFEDLASLDFENSSEIVFTVQFALTENPDLGHNIGNILNVTYSNAYPGGDDFYLASQNLVNAFKTDANGLPVFDGFDNPPHATGASYLNPVDPRVDFSLGRNNIPWKQSGIYTFSEWGRSADYPNNYSSKKHVIDSNDPRMHDGLPWAASGLNFAIIRYAEVLLWKAEALIEGNIDLNEARALINQIRNRAKNSTYVRTLDGVSTAANYAIEPYPTTGWNQSYARQALRRERRLELAMEGHRLFDLNRWGITAQTISEYLSDEYTVTPYLEGVEFVEGTHEYYPIPQAELDKNPGLYQQNNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSI0</accession>
    <name>A0A654DSI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="137"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="44643" checksum="818E141C18851FD4" modified="2020-04-22" version="1">MHFLKKSFLPSLLILSLLSCDSNEGEPSPQLPGISINDLEISERKEDFSITLDVTLSEVSADLVVVSYETVEGSAVADQDFKHITGQLIFQAGSVRESITLTIFSDEKMEDDESFSIRLFDPANAVMNDSSALIVIKNFDTTPPPNELVIPTQGYTSPESYDGWNLVWQDEFDQESLNTEDWTYEIGNGHSGWGNNELEYYTNENTSMVDGNLVITARKESRGGYHYTSSRIITKNKQEFKYGRVDIRAVLPFGQGIWPALWMLGANIDQVSWPACGEIDIMELIGGNNRDNTTHGTAHWSGANGYANYGGSKKLSSGIFADEYHVFSVIWNESSITWLLDGVEFHVIDTTPADLSEFRNDFFFIFNVAVGGNWPGSPNTSTVFPQYMIVDYIRVFQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSS9</accession>
    <name>A0A654DSS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024885171" evidence="1">
        <location>
            <begin position="25"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="305"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="628" mass="72936" checksum="742C0C67775E625F" modified="2020-04-22" version="1">MKYNFVKITTFLSFIFLFCKISSAQGYWQQRVNYEISIDFNSKSHQYTGEQTLKYYNNSPDTLFNVYYHLYFNAFQPNSMMDVRSRTISDPDPRVGSRIAQLSDDEIGYLKVISLDQSGTELAYHVSETVLEVNLSKPILPGASEVFNMKFEGQVPLQIRRAGRDSFDGVDYSMSQWFPKMAEYDKMGWHTHPYVGREFYAPWGDYEVNITMDKDYVIAATGILQNPNEIGYGYEDTGVKVNRKGQKITWRFKAENVHDFVWAADKDYIQTTAQVPDGPLLRFFYIPSEDTKYWEELPAYTIKTFEYMQKRFGKYGWSEYAVIQGGDGGMEYPMATLIANRKNSKLRSLNSLIGVMMHEVAHSWYQGMLATNESYLPWMDEGFTTFADEYTENFVLNKGSKQPLDYSYKKYFRWVEFGYEEPMSTHSDHYSRNSAYSIGTYTKGAISLEQLGYIIGDANRDAGLLRYHHEWAFKHPDMNDFIRVMEKQSGLSLHWYYDYWIGTTETIDYAISSVSEVKNGVKVDLERLDKMPMPIDLTITKKDGTELEYYIPLGIMRGEKPKETANERLVGEDWAWTHPTYSFSLDIPYSDIEKIEIDPSGRMADVDKTNNVVILRRVPENTPKNISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT33</accession>
    <name>A0A654DT33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="369" mass="41999" checksum="2561AE0618A09184" modified="2020-04-22" version="1">MNKFYVLGIFLALSGCYLGDDLPKDQNIWKYSQPAEVGLDADALYALNEALIAGDHNLVTGLIILKNDQLVFENYYNFSARNQLKPIGKSAFSIIVLLLDQILKDGYIQSLDDPIYSYLPEYETIFSNSPKKREITIRHLLTHKSGISWNEPHVNIQRGDSDFQKMRSTSDWPAYILGKSLEADPGLRFVINTGMGLVIARIIQNVLPTGQLEEYINTHLLEPLNITGYQWETSPDGTLNCANGLKMTTLDFAKIGYLVLQEGRWVNKQRLIDRDWILEVTTTKVQTSLDYSVGYGWWIFTEDFLNRYLSQVRNTYFLSGEAGQNLYIIPDQQMVVCVMAENYYYGSIFNPSLIVLLKSLEAAQHSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT49</accession>
    <name>A0A654DT49_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">trpA</name>
        <name evidence="9" type="ORF">MARINOS108_10256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="28874" checksum="E3DD1FC1FE74F231" modified="2020-04-22" version="1">MMNRIDQAFIDKKDHLLNVYFTAGYPELNDTLEIARHLNDGGADLIEIGLPFSDPIADGPTIQESSHVALENGMTLALLFEQLKDLRKTVQVPVLLMGYINPILQFGFEAFCKKCQEVGVDGLILPDLPMYEYEETYKEVLDQYGLYNVFLITPQTLGDRITKIDELSKGFIYMVSSSSTTGAKSGISEEQIAYFERIKALNLKNRKLIGFGISDYASFSKACAYADGAIVGSAFIKLLAEDKSAASISNYIHQLKNPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT65</accession>
    <name>A0A654DT65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="351" mass="39985" checksum="D84E34227EA95146" modified="2020-04-22" version="1">MSRSVNNHKAFPFLLVLLTITLLTPGCEEPYQFDKEYSRFILIDGRVTTNGSRVIVSYSGGYNSDSTILTPITDATVIVESFSGQYYVFESLLNNVYNPPEDFDPVAGETYLLTVQVGDKTILSRPETMVSALPFDLTATYAERTVFTANNEAEIRYGHDVTASFVRSIPETTFLKWKYEGDWEHPYTYVDYHEVTGSQFNLMSGSELNAAGISGFDVLWFPNQNDTYSEALDFAIQVEDLEEDDYIGTLTPENQQEILDSLTLVNDTTPAKQYVYTLRVIQSTLSERAYTYWDQILTQQRNTGTIFDALPAEFEGNLFVPNTNEVVLGYFSAEDIEMREYELFYIMDRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTJ5</accession>
    <name>A0A654DTJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="17728" checksum="37C838FFD69BC68B" modified="2020-04-22" version="1">MATSHFNPLTNLFKEMKKVKQTLLLIAVASMSAFMSCGPDDDGDKTEKEVLTEALVSTTWTADASVTDVSGVNGTFDIGTFTVKFTETADGLAFTLGGDISSYITGGTFSVSEAGDISNILVNSASAELSASVTSFVVNAARTSVSLNINVTEAGARVGGIGQYVLVFSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTM9</accession>
    <name>A0A654DTM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021953">
        <property type="entry name" value="DUF3570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12094">
        <property type="entry name" value="DUF3570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="425" mass="48237" checksum="C058DFBD31FACCC9" modified="2020-04-22" version="1">MVRIREILAGALISAHLMIKAQHQRSEVDDSQYADEVLVNNYPAQEAQILSLTDSGASQAVDPLQVEIVYNHYIQDGSNSAVTGGIGTENLTVYGPSLRVRKDRANHYVQMQTGVDIISSASADNIDFIVSSASRLDGRGYLYGTYGHHLRGSGLTLDGGLGLSLESDYSSLKTEIGVAKESADQMKKYSLQFQMYNDDLRWGLFHSGYYRPTKLIYPFELRNRNRKWYETHNRNSYILKGGYTQVLNRRNMLGLFTDLTLQKGLLATPFHRIYFTDGFLKVEQLPYERWKGGIAFRLNSFVGGAIILKNTVNLYSDSFGIRALTTQNETSIKITPVLIVTPHFRFYVQQGSRYFAGYGEHERTERYFTSDYDLSSFETYTMGIGLKKRFVHKSALQTVALRYSYMHRSNGLQAHIISTSFQLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS9</accession>
    <name>A0A654DTS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="20672" checksum="B136CD401789F761" modified="2020-04-22" version="1">MNPLEDLLEKIESLGLWEKQLTLSRNEYLKVKGSTDTRIYLIVSGSLRVFVTDDKEEHTIRFGYQGNLIAALDSYITGQPSDLYIQALKKTTVKAISKKAFDSFVNGSEANMRLWQEILTALIYQQMERERDILTSSPMDRYNRVLTRSPQLFQEIPHKYIASYLRMTPETLSRIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU71</accession>
    <name>A0A654DU71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="29224" checksum="85FE4BACD91531E2" modified="2020-04-22" version="1">MNTKNFFDFSRFWSLLKLELFRSRKGVFMTFLIAFGLLFFVGMLLAIVTEPDMKVFDHSEGYAYTLILGGFILSSLAYSDLGSTLRRYTYLNLPVSTLERFLSMWFLTSIVWIVLFTLTYTAYTWVANYLGQLLFSRVTFYAFDPLSAFTITTMKCYFVLQGIFLVGAAHFRGYVFPKTVSVFIVLAVICGTVVYFMLREPFLSEHECSGVDCELIDVIAEQPIWAIIKWLFWWILAPLSWVITYLGLKGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU91</accession>
    <name>A0A654DU91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6091" checksum="199AFA3415469DBB" modified="2020-04-22" version="1">MENELIPKEAYAEIEQMITSAESVVGIDAKKTHIIIIHKLMEIEKRLKALENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUA7</accession>
    <name>A0A654DUA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024893079" evidence="1">
        <location>
            <begin position="21"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="331" mass="37193" checksum="52A31FA5E36D30E3" modified="2020-04-22" version="1">MTRLLGSVCLLYVLSVAANAQFLNTDQKDVEKIKNSTLLLVLEEPDPKIVSKLSKKYPKALEDYQNQIAGRNFALRYALENFWDLTEKVEFHPESTAFDLIEKNPDQYLLISFGQYLEYERIGLVSGSDGDPAGWRTSSTGELTYNHTSKYTVLSREITTLEISDTKPLVSVFLPSVYPSLSGAVYGVQQIQYLLRYLAADGENKMSKMPKQIEANNPKLKDKILLIDQNDVDPKVTAEELAEVYPYPVQLVDPSVIREAILARDASYAYLQIVSTPGERGSIDTHVIADASDGKIYYYVTPGLGVGSYSALITDYRTRIKERHFKSYAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUG5</accession>
    <name>A0A654DUG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025245">
        <property type="entry name" value="DUF4197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13852">
        <property type="entry name" value="DUF4197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="235" mass="25921" checksum="880026734398B74B" modified="2020-04-22" version="1">MRLVCLYIVFIFLAGCTVQQIQQTLGDYLETDELTTEQVTAGLKEALVKGVTTGTSKASSLNGYFGNPKIKIPFPPDVQRVEDKLRSIGLGGEVDKFVETLNRGAEEAAKEAKPIFVEAIKGMTVQDAWGILKGTDNEATQYLKAKTSAQLTAKFQPVIKQALDKTSATKYYGDIISTYNKIPFVDKVNPDLESYATSLALEGLFTLVAEEEREIRANPRARTTELLKKVFAQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR2</accession>
    <name>A0A654DUR2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024881477" description="Cadherin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="1488"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1645" mass="182712" checksum="C62C4ACA3F374B24" modified="2020-04-22" version="1">MKQVCMIVLLTILCSHYTLIYGQNPFDQPRAYPIPIDQNQSGSQAPLDAQGETKQGHSFLRPQNSPMIPSFQNAQSNLFQSDGTSPQIRTCFTVENEQKLREKYAGRLSTDDFEARLSRQLALSRMSADPETIYQIPTIVHVVHSGEPRGTGSNISREQIMSQFDVLNEDFRRLGAGYNEHPDGADINIEFVPVLTDPYGNLLEEPGVDRISGYSSSYSYTVIEEELKPNTQWDPYRFFNIWVLDFGSSGLLGYAQFPNLSGLDGLPEDGFDFTDGIVIGYQFFGRTGQVSAPFDLGRTTTHEVGHWLGLRHIWGDGGCDMDDYCEDTPVADGPNRSCETRDSCPGGGPDMIENYMDYSTDGCMNIFTKDQRMRMRTVMEMSPMRNALIVCQLAPPAVAGSNTAEMPLSWYEYTAADHEVVTISSMGAIVDTKLSLFRECHTLPISESDDAYGTQQSELSIALQAGETIKILWENRQFDPFTWQLTTSTPEEGAACGVAAMALEGNNTLPTTSLGTYWYRFSPDADHQKITISAGDMTFNVYGNDCNQLKYIKGGKGTLTMFDVSADQSLFISFEPQGGNVDWTLHTTSIRSGEACSDAVNAMEGQNTIPYEAPFEYWYTFTMPATGNLTLHSAETSTESVDLKVFNECGGFLLGSTAGDGVELTTALEEGETVKIVWESASAVAGYEWVLIASPFENGEVCSVAREVQAGLNHTDGAPQWFSFTTTKRSNLVISSIGLTDVNTHLMIKRECHGQIFMDNDEGHDTHYDFYDQAQLVLYMVPAGETFYILWSEKWSYEGFDWTIEEIDPLPGDNCGTAVQAHTGTNQVTVDRDHYYFGHLYWNKYTVPANGKTITAFSSEPVEMAIFVNNDCQLFSWVDSGQGKGRAVNLPAGTELVFIWSLDYFNENFTWELTVENIQAGDHCESPISAVKGDNISESAPVWYDYQMAEDGSLKVSYQGDYIDGSPFVAILDGCTNADLLYSGVGEAFVSGLSKGQEVSIYWSINYPFPGIKWKLEEIPVRQGDRCEDPLVANYGLNHAEYATHWFTYNVETAGNYTISSMPFTYSNTLLSVYDGCDGNLLASNDNILVLDDWIEYFQSSVTLENLEVGQTLLIKWDGAYSYEAFNWEIVTDQPRPGDSCEDPLLAVEGVNNGMRPMPAWFTFTMPETNSFSVSSVGYTSNDTYVEIYDVCDGELIAYSYDYGGDPQSFAYLPELEAGQTVYIRWANSMNSAQYSFDWKLFVGDPELGIFCESPDQAHEGVNTVPDYVSNFYWFSYTMPEDNKKLVISRLDLSTARYRTIGVTPECSTLSSYAISEDRVEVKGLMAGDEVLIFFGELIDGTRPGFDWGLEIVEMESGDHCDTAIEVLPGLYEFRGAPKWYEYTLPKAGDVTLTSIGLNNVSYANSYIEVYDACDGNLIAANDDPENVAVHSMAEVIIEDLEAGQKLLIKWGSEPFQTDFNWMLSVAADNEAPTLADHHFSLSKFTTGHLIGALSAEDPDDDELVYQITDGNEDGAFSLSNTGELRIADVTKLPAVGGERTLTVSVSDRIAQPAEATLTVDMVLAVEQQHVGVVVFPNPATDRLYLRLASQVQVYESYFVDLTGRIVQVNNARETEISLLGLRQGIYFLKLQTTNGPVDFRVMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW0</accession>
    <name>A0A654DUW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="104" mass="11979" checksum="912DA0D49E67A634" modified="2020-04-22" version="1">MANPHDLIRNTEIILISSNPYEVDMMLSSLKVSEETCDLLWLKDSQRTFDYLRSRGLYKGNELGSRARIFILGKNFPEIDGIISLLQSDHRLLGYPVYRFALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX0</accession>
    <name>A0A654DUX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="19744" checksum="384A239489E004E1" modified="2020-04-22" version="1">MEVIERDKPYVFVCNHQSYLDIPILFRAIPANLYFVAKKELRIIPFLGWYMMATGMIFIDRSNRKKSMESLKRSAKLINQGKSVLMFPEGTRTVDHQIAHFKKGPFILSKEANVPILPIGIRQTGKSFTWGKWSSTQMVVSVSAPITCDGSAEVVEQVREKVALLANKPVASLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ1</accession>
    <name>A0A654DUZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenite resistance protein ArsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ORF">MARINOS108_10449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="40988" checksum="1719719960B6445C" modified="2020-04-22" version="1">MNWQINFCKPNSYQTIITIMTNNTKKLSFLDQYLTLWIFLAMAIGVGIGYLFPSTSTFIDSFSSGSTNIPIAIGLILMMYPPLAKVNYKLLPQVFKNVKVLSISLLLNWIIGPVLMFILALTFLQDYPEYMVGLILIGLARCIAMVLVWNDLAEGSSEYGAGLVALNSIFQVFAYSFYAWLFITVLPPYFGFDGAIVDISIVTIAESVAIYLGIPFLMGILSRMVLVKAKGEDWYKTRFIPTISPITLIALLFTIVVMFSLKGELIVQIPMDVVRIAIPLLIYFALMFLIGFFISKAMGADYDKNASIAFTAAGNNFELAIAVAIAVFGLNSGQAFTGVIGPLVEVPALILLVRVAFWLRKKYYPAKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV19</accession>
    <name>A0A654DV19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="338"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="528" mass="59691" checksum="8E48CBF23659BDC2" modified="2020-04-22" version="1">MLVLQNISYLHPNNDLLFDGIHLAVNRQEKVALIGNNGAGKSTLLKLIAHELEPSEGQLKTEAPPYYVPQIFGQYNHLTIAEALRVDEKLKALHEILNGNTADSNFEKLADDWTLEERCMEALSHWQLPHLDLTQKMETLSGGQKTKVLLAGIFIHQPELVLLDEPSNHLDMSGRKLLYEFIESTNCTLVVVSHDRTLLNLLDATYELNARGIMVYGGNYDFYAKQKQIERDALDQDIHGKEKALRKAKEKERETLERKEKSDARGKKKQEKAGVARIMMNTMKNNAEKSTSKAKSIHAEKIGGIAEQLHELRSQQFDIGQMKFGLNDSALHIGKVLLTAENINFSYQTQWLWNESLSIQITSGERIALKGANGSGKTTLIKLILGWLAPQQGTIRIARNHSVYIDQDYSLIDNALSVYEQAQQSNTSALLEHEIKIRLNRFLFTREDWDNPCMALSGGERMRLMLCCMTINSQSPDLIILDEPTNNLDIQNIEILTAAINVYQGTLIVVSHDESFLTQINVERTIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA3</accession>
    <name>A0A654DVA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22742" checksum="7A76437AF918213A" modified="2020-04-22" version="1">MNTDRLTQQLAFIREIDKLKYIQRKTRLFNSQRHENDAEHSWHLAMMAMVLAEHASTEVDLFKVMKMLLIHDIVEIDAGDTFLYDTTQSHVNTEVELEAAKRIFGLLPEEQMRDFIALWEEFEAGETPEARFAKALDRLEPIMQNASNQGGTWAEYDVPLSRVLEKVQGIRKGSDSLWAYTEDLLRENVENGNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS6</accession>
    <name>A0A654DVS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (Long-chain-fatty-acid--CoA ligase)</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD</name>
        <name evidence="3" type="ORF">MARINOS108_10774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="470"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="559" mass="62051" checksum="0759E021DE181D5C" modified="2020-04-22" version="1">MKDYPWLAQYPEATPHEIDPDIYPSLVAFLADCVAKFGDKSAYENMGVEISFNDLDVLSTAFANYLMHETNLKKGDRVALQMPNVLQYPVALFGILKAGMVVVNTNPQYKPSEMEHQFTNAGAQGIILLNTFAFKLEEILPKTPIETIIIAEVGDMLGTLKGALVDFMIKRVKRMVPDYDLPTAVDFQDVIKAGKQHTYVQPEIKNTDLALLQYTGGTTGVAKGAALSHRNLIANIEQVAAWMRPRLVEGEEVTITALPLYHVFALTVNCFGMLKIGAKSVLITDPRKMGDFIKVLKNHPFSVITGVNTLFNGLVQRPEFQSVNFEHLKVAVAGGMALQKAVADKWKYLTGNDIVEGYGLSETSPLLTCNPIDGTEKLGTIGLPVPSTEIKIVSDEGETQGVGDFGEIWVRGPQVMMGYWQNQAETDIVMEGEWFKTGDIGFFDSEGYIKIVDRKKEMINVSGMKVFPNEVEDVIAQLEGVLEVGVIGVAHKNSGEVVKAFIVKKDKNLTEDMIMKHCRDHLVAYKMPKFIEFREELPKSTVGKILRKELRKEEIANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW91</accession>
    <name>A0A654DW91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6038" checksum="CA60832A228F67B9" modified="2020-04-22" version="1">MLRALQTGMNDTSSFNPLTSSGFGPSIAQNEYRNPLMVRGYEGVLFLIISLSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW93</accession>
    <name>A0A654DW93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_11193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="16001" checksum="83539E62DC243032" modified="2020-04-22" version="1">MRVAVFRKEHFNAAHRLYNPDWTDERNQEVFGKCNNPNWHGHNYELVVKLVGEPDPATGYVFDMKELSDLIKIHVLRKFDHKNLNLDTEEFKSINPTAENIAVVIYNILREKIDRTLELKVILYETERNFVEYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWC0</accession>
    <name>A0A654DWC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3859 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024331">
        <property type="entry name" value="DUF3859"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12975">
        <property type="entry name" value="DUF3859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3859" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15967" checksum="F21A08630FA1523C" modified="2020-04-22" version="1">MHRLVLPSLMKKKNTKTIEIEIINYGAYSEWDRVSNELPKFMALANTVDAVIGAEFGMIVEIRKAKGRYLDFLIEHPPFTDETGAVEPPFRGTFRVKHNPFQFFLGDSIWAPVEDKRGPWKLSILLEDEVIISKTIMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD9</accession>
    <name>A0A654DWD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="391" mass="42141" checksum="E7E1ED381E1176DD" modified="2020-04-22" version="1">MYLAQHIRSIQLFKYSLAISFVLIGFFTSLATVITVDNNENSGALYSSIQVAIDDATVGDTIIVAGSETTYDGFTLNKKLVLIGAGYQSTEDAQFGFTTKVNHMVIKNENPALDLNASGSHIEGFYVNGVVTTAGGNYRYISVGFEGTESNTLTNVTFTRNRCESVHLSYFSNIKIYNNILDNIGYAPNYNSVYGDYPFGSNLLVANNIFTGGVARVKGSQIFINNLFIGSDQVYDVFFSGVGITNQASGIVFSNNILWGRATGGASNVALTHNLVLTSEGGETFDYGTNSTGNNLENVNPKFVDVPEFALDFSYDYRLAEDSPCKGTGSDGTEMGIFGGPYPFPSAGDVPNVIVTESRIPKITDFNIRSAAVPEGSSIEIDLKARVSNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP8</accession>
    <name>A0A654DWP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025058344" evidence="1">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="58"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="202"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="460" mass="50560" checksum="819CBAD036571EC2" modified="2020-04-22" version="1">MKRITLYLFNIVICLAVFAQKQTPPAGGTPKDFTLPEKTTFKLDNGLTVVMIPYGNLPKVTVSAVVKTGNIHEGEGQIWLADITADLMQEGTTTRTAQEVSLAAANMGGQINIGVGPNQTTASGEVLSEFGADLVGLIADVLQQPAFPGGELSRLINDRKRDLSVQMSRPQPQATEKFNKIIYGNHPYGDIYPTEEILDSYTIDDVRKFYSDNFGAQRTVVYVAGVFNEAEMKEAITKAFSQWVTGPAVSFDVPEAVAKPGVEILDRADAPQSTIIMGLPVVDPSHPDFIPLSVTNYLLGGSFASRITSNIREDKGYTYSPRSTVDTRYGAATWYEMADVTTDVTGPSLKEISYEINKLRSEVPGVEELDGIKNYRAGIFVLQNSSPGGIIGQLSFLDLYGLDDSYLTEYVKNVYAVTPEQVTEMTRKYLDYEKMTIVVVGDKKVIEKQIEDYQNALDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS5</accession>
    <name>A0A654DWS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Intracellular exo-alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="5">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asdII</name>
        <name evidence="5" type="ORF">MARINOS108_11112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024932738" evidence="3">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="318"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="513" mass="57396" checksum="C1205BAB58A26475" modified="2020-04-22" version="1">MKMQRIATLLLALGLSHLVMAQNASVIINADQGEHQISRHIYGHFAEHLGRCIYGGFYVGADNQAIPHTDGVRNDIIQALKDLKVPNLRWPGGCFADTYHWKDGVGPQSERPTIVNRWWGGATEDNSFGTHNFLNLCEVLGAEPYLSANVGSGTVQEVIDWVQYTNHDGVSPMADWRRANGREKPWAVKYWGVGNETWGCGGNMTAEYYANIYRQYATFMPGWSGSTKIERIASGASGNDYHWTETLMKNVPHQLMEAVALHHYSVLDWSDKGSDVAFSEAQYFKTMEESLKMEEFVTRHSTIMDKYDPERKVALFVDEWGGWYDGDTAKGVLYQQNTMRDAMIAGAVLNIFNNHAERVKMANIAQAVNVLQAVILTDEEKMILTPTYHVMKLYNVHQDATLLPLSIDTPDYELDGKKLPALSVSASRDDQGVMHISLVNIDAKKAHSTEVKIHGDEVKTVRGSILSSASLQDHNTFDNPDKITPKDFKDFKVKNGILTVSLPPFSVVVLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA1</accession>
    <name>A0A654DXA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5442" checksum="2AFF1BB49DEEC385" modified="2020-04-22" version="1">MQNRTNPLWIQKSRDIKEGGASKPCPAGTSVNHFDSKNSSKKLKPDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA2</accession>
    <name>A0A654DXA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="5">
        <location>
            <begin position="74"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="4">
        <location>
            <begin position="219"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="50071" checksum="C72CDD3CFA1D652E" modified="2020-04-22" version="1">MVPLEWNLFNSISSLSGILPSFLRNLSGIEFWRSSFDVRIANTSKESASQWIYGLSHLLMGPIKRQIMSMTDMGVIGTSKKADERRVPIHPEHLLRLPEEVRKHLIFEKGYGESFGIDDQEMASLSGGLASRKELLGEIGNVIIAKPVISDLQELREGGVIWGYPHCAQQSAITQCAIDRKLTLIAFEDMFVWSPAGLQGRHTFYKNNEMAGYCAVIHALQLKGIDGHYGNQRKVIIFSFGAVSRGAIYALKAHGFRDITICIQRPDHEVREEILDVNYTRIRKGRAGEPRMLLVEHDGSERPLSELIHESDIIINGTYQDTNDPIDFIIEEEQAILKKGCLIIDVSCDEGMGFYFAKPTTFKEPMFAVGSADYYAVDHTPSYLWESASRSISAALIVHLPTVLSGPAAWKANETIHQAINIDQGVIQKDSILRFQNRALPYPHLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ4</accession>
    <name>A0A654DXJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="549" mass="63480" checksum="A86498EDB5E0403B" modified="2020-04-22" version="1">MMNNPPVKIFSFEQSSKPPRAERDSLLKAGVEWCSVVTTQEQWLQALIDALDKENDQTVVLVISDPERVSLSGEVAILADRFALLGTDVVFAASSTYLLEDQRLHYFYWKHYSRPHERYNYLDSTAFMGTAGDLKALLRQAMERYGEQCSYHDALSRYYADSASGCFQPEVNFIIDHDQVLIASTRLSAKPQAQKGWMYEMLYARNERDIYSQNHLISALTKSLNVSREGDTFRHLTGTNPLVVVQDAPSPVTPGKASFLLNMRAHLQTVRQLFLIGKANKWHFQKERIFRHLPNKSAVIHKATELLVGRLEAKKPVSFAHYNDGELTFIQDFLKGEQHEKWFGRKQQQYNPVLAERLYEAMRFQKEGYLVGVPCSLDHPKLRKQADEIVGDYVHKVQAMAIHHNLAFMPRLLEALKGREVYFFTNEYQDLSFFEAFGIEMVSERIFQVPFRNSYLEYDRFKDMRFPDEAVVVLTCGMLAKILTKVWYENHDSLSVLALGSSLDDHIQKKNISFELYPSDLPLTRNLHHSRSFLFGYKPTCKECFDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK7</accession>
    <name>A0A654DXK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6522" checksum="31D9C3B4362C2E92" modified="2020-04-22" version="1">MFEKLFGKKSGTSLKMRYSSSERQWQVYSDGNLVFVGDKLGCENFITNSNFAYQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL2</accession>
    <name>A0A654DXL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-(Acyl-carrier-protein) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="45200" checksum="B1268CAD10428FAD" modified="2020-04-22" version="1">MKNRVVITGMGVVAPNALNVDEFRKALQEGKSGIKRYENLGEINFKCQLGGKPPVTQEYKDEHLPHFVAQKVKNNAVIYACLSGLEAWNDAGLEIKPGGYDRKTGMLVGSGALGLDSFIEHKIYPIDQGNHRKLGSRSVPESMSSGAGAYLNSILGLRGRIFSNSSACITGSEAVLQGFEMIQSGKMERMLCASSEGDGRYIWGGFDAMRVLCSDSNEAPEKGSRPMSATSSGFIPSGGSGALVLETLEAAQARGAKIYAEILGGEVNSGGQTDGGSMTAQNPQAVVDCITTALERSGVAPEEIDLIAGHLTSTKGDPYEVINWSTALNLPKDDFPYINTPKSMIGHCVAGAGSIELVASALQLAEGFIHPNLNVAEIHPEIEKLVPLEKIPSKLIKKDIKTVIKANFGFGDLNCVLVLRKMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY18</accession>
    <name>A0A654DY18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="7335" checksum="25BF4CC7981C2DB8" modified="2020-04-22" version="1">MRKTLKFITWTFMGLAVIFFWISLRNAENNLEYTIVAMMMIAIAWGTNYFLRKHEKAEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY26</accession>
    <name>A0A654DY26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cda</name>
        <name evidence="4" type="ORF">MARINOS108_11274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16016">
        <property type="entry name" value="AP-SPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026263">
        <property type="entry name" value="Alkaline_phosphatase_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031924">
        <property type="entry name" value="Pi-irrepressible_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024900011" evidence="3">
        <location>
            <begin position="19"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphothreonine intermediate" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR031924-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR031924-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="539" mass="59437" checksum="60DDE9388AD2BD69" modified="2020-04-22" version="1">MRKLILILFLLPSLSAIGQAKKPKLVVGIVVDQMRHEYLQRFESKYGNDGFKRMIRDGFEARNNHYNYIPTYTAPGHASIYTGTTPRYHGIIGNDWYSRVLGRSVYCVGDTSASSVGGSALSGKISPKNLIVNTITDELKLTTNFRSKVVGVSIKDRGAVLPAGHAPDGAYWYDSRTGEFMTSDFYMDALPQWLVNFNQKKLVDKYSNQTWNTLIPIAEYTESTPDDNSYENGFKGKETPTFPYDLKVLRESNGPYGLIRSTPFGNSLVLDLAKASIEGEQLGTDQITDFLSVSLSSTDYVGHNFGPNSVEVEDTYLRLDKDLGDFLTYLDKKIGVGEYMVFLTADHGVVANPQFLLDNGLPGGYIDTDEVKEIFAEAAQSLGDYILSTSNDQIFLNRDLIDSAGLELEAIQKAFAEAAMKIPAVAETFTATSMDTFDYTDPMRSNLQNGYNRKLSGDVLLFMKPGYLTNTYGLKGSSHGTGYSYDTHVPLLFFGAGIKKGATVEKTYITDIAPTLAMLLNISIPNAAVTGAPIEEIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY38</accession>
    <name>A0A654DY38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP</name>
        <name evidence="8" type="ORF">MARINOS108_11813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="9"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="416" mass="45261" checksum="11190FC97A93BC54" modified="2020-04-22" version="1">MSIFNIITILIILSAIFAFINTKFLKLPFTIGLMIIAIVFTVGITILGSFNHYILDEAKLLIQSVDFETALLDVMLSFLLFAGALHTKLDALKKQKGPIALFATIGVVLSTFLIGTMMYYLFMAFSYPIDYVYCLLFGALISPTDPIAVLGILKEANAPKKLETKIVGESLFNDGVGVVIFIVLFKIAQQGLDSMSFTDVSLLFVSEVAGGLILGLLAGWGAFRLMKVIDHYETEVIITLALVMGVSALAHYLHVSGPLAVVVAGIFLGNKAPKIAWSDNTHLYVDKFWELIDVLLNAVLFVLIGLELLVVTMNGAYFLFGLMAIPLALLARYIALSGPVAIFKNKLNFIPQSNLIMTWGGIRGGISIALALSLEPQMGRELFLTVTYVIVVFSIIVQGLTIAPLVKKVLKGSEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY70</accession>
    <name>A0A654DY70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025030015" evidence="1">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="41862" checksum="290F8159B8B86E62" modified="2020-04-22" version="1">MRSILAIFITLFCWGAFAACPSPTTTGNFLNPSGRIDDHTDLVSDDCTLDPDDYSSLRINNNRTLTVNGNLLITGNFTIYGTLVVNGTVTIEGDLTIDGDGQLILNGGSSMEVQGDIDNGGFFSALFAPAGQGGSVAGALTVGNDFNNNNGGVMNVGDGGVMDIGGALNANPGSSMTVADGGTMSATTVNDPGATVSGPDDCSDGCCGVGCGALPVTLLSFSGAYEDSAVVLSWSTASETNNDFFQIERSEDGAEFDIVARVSGHGNSKSLIEYEYRDEHVSATAYYYRLLQVDFDGEYEYFPAIAVAAAAIPGERFSVFPNPITRGDLTIVCPEISQNEVPKVYLYDANGSVVLHKSLDAEGSRMVLAQADESLIPGVYLLRLVTDSQAYTRRLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY89</accession>
    <name>A0A654DY89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="43007" checksum="6620FAC1098D9587" modified="2020-04-22" version="1">MNQLSERRISLWQLLISVLKVGSISFGGYMALVSILRDELVDRRRVLKDEVIMDAVALASIFPGPLAVNIVIYVGYKLRGKAGMLIAFTGIILPAFVLVYILTYLYFEYGDVLNVEPIFKGVMPAVGAIILSVAIKMTKSHIRHRVQVLLLLISIATLLTFTGFKTIIVLVAGGAILGYLFFRHEVQGSNDLNEIPVSRFNGKDVQVVALALVAVAGVLLALALFGEKSMVLQLISVFSAMSLSLFGGGYVFIPMMQEVVVESLGWLSNAEFIDGIALGQVSPGPIMISSVFIGYKVMGITGALVATAAMFLPSGILMVAGSQMILRHSDSILFKSAMKGVYAVTIGMIFNACVKIGMGLEVDVVPIAIFLVGSLCLIRYKMNLIYVILSAGLAGSFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH3</accession>
    <name>A0A654DYH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025491">
        <property type="entry name" value="DUF4382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14321">
        <property type="entry name" value="DUF4382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4382" evidence="1">
        <location>
            <begin position="50"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="317" mass="34458" checksum="5D6B252373DFB3D2" modified="2020-04-22" version="1">MIQFWNGLWRIESVPKIMKVMKTFKSILAAILIVGTAGFLMSCESELESKGTASIGVTDAAVDAENISGVYLKVNEVQATAQGKTKTVVAFDSPKTFNVMDYQNGATYDLGEGQIDAGSYSELRFILDEGSYVKFKDGTTADLDVPSGTTSGYKVKGDYEINSDSRTNLVVDIDLRKAFVKTGSGEYKLRPTARIVNKDRSAVINGTVSGNTADKVVVYAYEKGTYKESETAEPADGESRFENSINSAVVANGQFTMAYMEEGEYDLIAVAYDENPEEDTYAFRSASEVDMMVAGSLLSVLKVEANANINVLINLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN4</accession>
    <name>A0A654DYN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="165" mass="18642" checksum="B4ED3C274EA3E837" modified="2020-04-22" version="1">MGLFSKIKNYITGGAASVSVVFESPMVDGSAPIRLFVTAIAKDDCKIKKVYLNIRARETYIKTVTYTETDGDGNSRTSTRDETRFEDHFQKEMILATDLELKKGAEDKWLAEFELPEDTKATYHGKSVFFKWEFQAGLDMPGNDPDSGWVELLVSKAMNYTMNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS6</accession>
    <name>A0A654DYS6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024967944" description="TonB_C domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="2">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="24540" checksum="987E20916DC0ACFB" modified="2020-04-22" version="1">MSRELVLVILIVLIASLTGASQPSDVDNGYERGKLENGYKVGVWEYFGNGDSVELKINYDKGTLVYLKPDTSKYFVMIDSVWTYKHVNPYPRYLGAYAEFYTILGNNINYPTAARRDQIEGTVFLIFEVNTIGKAVNIAVLNDNGGYFTDEIIDVFNLIPNLWLTASYNGKNVPSKFILPFYFKLTGEKESSAFDITTLSTLEGKKLLEVIVTTPRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV3</accession>
    <name>A0A654DYV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="419" mass="46294" checksum="D1663FC184BFEAF1" modified="2020-04-22" version="1">MNMVRSYTLALVLGLTFSMCGDVIEEDISGREVVLLSPADSAVLTMDTVSFWWEPVDGARSYEFHLVSPGFETASRVWMDSVTTSNLITMVLPTGAYEWEVSGFNAGYATQFFYRSFRIDTTASGSEIALQGQPEIISPTNGSLIIGKTAKLWWEKMPGATHYEVRLVSPSFSDLQELLLDTLTASNKMSVSLPEGSYEWELRGTNASYASDWVRQSFAVDSVQVLDISQETIGQLSPSQDVLIIGAGVDLWWEQVTGATAYHVKIASPNLANPQRVLLDTSISQNQLHKALPPGTYEWQVRGANARYQTGTASGTFRMDVAVDISGSTVKLSAPGDSLVTSMHDLTFWWEELAGAETYDFILVSPSFDHIELLVNEQELVSNKLQLNLDSGSYQWGVRAKNEAYVTPLSIRNLYINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX6</accession>
    <name>A0A654DYX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_110049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024191">
        <property type="entry name" value="Peptidase_M61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040756">
        <property type="entry name" value="Peptidase_M61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17899">
        <property type="entry name" value="Peptidase_M61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016493">
        <property type="entry name" value="Glycyl_aminpptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024884902" evidence="1">
        <location>
            <begin position="20"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M61_N" evidence="4">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M61" evidence="2">
        <location>
            <begin position="280"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="475"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD15873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="595" mass="67759" checksum="281F4367764EFE19" modified="2020-04-22" version="1">MLRILFALLILTGFSQIKAQTPVRYSLGLDNIHHHELRITATFSDLTGETLEIRMPNASPGRYAAHNFVKNVYEEMAFDAAGNQLPLKRITPFSWEIPVTEGIVNFAYTLYGNHADGTYMGIDAKKIHMNMPPTFVYAPELQDREIELIIPASNPEWEVATQLIKKNDSTFSAPDYYYFYDSPTLVGEISWRRWDVEGQTIEIAMMHEGTEAELDSYTEWVKKVVKKQQEIYGSLPKFDFGKYTFLVAYNPWVDGDAMEHRNSTVCTGTGSLRANAHQYISTIAHEFFHAWNIERIRPASLEPFDFDVPNLSEALWFGEGFTSYFEKLVLTRAKILEPEQYIKGLVGGLNYVLNSPGRSFRGPIEMSHNAPFTDAGTANDETNYANNFISYYSYGAVLGLGLDLTLRTKYDKTLDEYMRAVWLEFGQTEIPYTMADLQKVLGELTRDPGFAAAFFERQIYDSNLPDFEALFAEFGIKMSLQNPGSAYFGNPKLDDDGYVQSTILRGTAFYEAGIEKGDQILTMNGREISTTSDLNRVINSLEIGKEYTVTYKQFGKEKTGTFTTVQDPRITLSYLSNDKLKKAVIKRRNRWLHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ23</accession>
    <name>A0A654DZ23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_110015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="304" mass="34068" checksum="8128E4160CC2AF84" modified="2020-04-22" version="1">MEKTFNEIWADLVIAIKRLVDIFGTSLFKLGENDISLATILYIIFSFIVLTFFARYIKKILIEKILTRTQLDTGVQASVGTVTKFAIILVGTVVIIQSAGIDLTVLTLIAGALGVGIGFGLQNITDNFISGIIILFEKPIKVGDRIDVGDVQGNVISISFRATQVLTNDNISVIVPNSEFISSRVINWSHNDRNIRFKIPVGVSYNEDPEKIKKILLEVADANPHVLKMPETTVLFDAYGDSSLNFYLAVWTATHTDRPSVLKSELYFEIFRRFKEENIEIPFPQRDIHIKTQPMVIETSKISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ67</accession>
    <name>A0A654DZ67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Aspartate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MARINOS108_12010</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_aspartokin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="entry name" value="PTHR43070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000727">
        <property type="entry name" value="ThrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="20">
        <location>
            <begin position="312"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="20">
        <location>
            <begin position="393"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00010046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VXD14537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="809" mass="90006" checksum="16E0FBE30D529983" modified="2020-04-22" version="1">MKVLKFGGTSVGSEEAIRQVARIVHSSIDQLVLVTSAVGGVTDQLVHIGELAASGRKDYASFIEGVKVQHEQLYYNLIENKPDEQFYKIIEEFEDICKGVWLLRELTPRSADYIYSTGERLSTLIISEFFRNEGIDVTLYDSRDYIITDDHFGHAHVDFKETTKRLKEVSKTFSKVNLFPGFIASTADNQTTTLGRGGSDYSAAILAGVLDADHFEVWTDVDGLMTADPRMVKRAHFIEHVSYEEALELSHFGAKVIYPPSIQPALEKGISITIKNTFNPEHPGTLITKEWDQDKELIRGISSIKDISLVTLSGNSMVGVPKFSYRFFRALSEAHINVILITQSSSEHSITVGIDTKDSKAAVKALNAEFEEQIENHKIDPIQAENNLSIIALVGSNMKNQVGVSGQMFNVLGKNGVSIKAIAQGSSERNISAVIAKDDLNKALNVLHESFFLSVTKRINLFIIGTGNVGKAFIQQLVQQFTYLKKHHQLNIKIIGLGNSRLMHFENDGIPLSKWESILQAGEKYSSEQFLEKMYNANLRNSIFIDITASEDVAGLYPQILKKSISVVTPNKIAATGSYADYLNLKGMSRRYGSRFLFETNVCAGLPVLSTLSDLVRSGDQIHQIEAVLSGTLVFLFNEYNGKTKFVDVIKKAKQLGYTEPDPRLDLFGSDVKRKIVILIRESGYKCDYEDIQLNSFLPESCLESNSVEDFYTKVEKEEAHFKNLYEAANKEGKRLKVVAKYKNGHGSVGLEAVDSAHPFYNLEGKDNIVLFYTNRYKEQPMVIKGAGAGAEVTASGIFADVLRLAQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ92</accession>
    <name>A0A654DZ92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024959299" evidence="1">
        <location>
            <begin position="25"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="624"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="967" mass="107274" checksum="43603AB8E3B6B7C4" modified="2020-04-22" version="1">MNYTKGFILLVLFGSLIGVTTAQSNQTVTDAAISKMINAYKSDPKGPYKDIRWFCKDGSTVAPQERCPEPGVQRARYKDEVVALGASHHIFLGQILSTTAHEDFWDSEYQGSRMKQYSLEQYLRANDGGWINRRAQFYRGAFQAEDEEAWGLAYLQWLLEDKSRLVGQFFLIRQSAKDIPHSGDNNTAQSVRAISKEISDVYNPFMDLRVKLHGQPEESDIQKVRDFQAAHSAKLNAELKEKFTSLLAQMEIFYQPVAISDFKSLAKKVPNSLPANGTLVDFMEQYSRARTSGDRCELIATTGLALRRQIVNPMKSSARLALMDASIKMEAMLIRESVLWRPETLAELLIKSKTLAQAATGFGYLEIWEWETLDANLIIVADGEITLKELGDDLDHLRRSVEWSAGTFRATYQEVVKRYGSFEPLANGFIDDRVRASCLLQLGSSVSLLGDFFADQAGFSNQLLGIKNQSAARGLNPGYAMGELVVTNQSPEEIEVSGDKIYVFNRPPADLKPVAGIATVTEGNMVSHVQLLARNLGIPNAVLSMENLTALLPYNGKKVFYAVSNKGTVLMKLATEMTPEEKALFAKKVRNEEKISVPVEMMELDDARILNLRDVNASKSGIICGPKAANLGQLKQLFPDHVVNGIVIPFAIFKQHFDQAMPGQGMSYWQYLKATFKVAGEMSTAGSTDGEVEKYVMGRLEVLQVAIRQIKLMPEFEAALNAKFKEAFGVSLGKVPVFIRSDTNMEDLKDFTGAGLNLTLFNVLDAQKILQGIKDVWASPYTERSYKWRQKYLLNPENVFPSILIIPSVDADCSGVLITKGVTTGKPDDNTVAFNRGVGGAVEGQASETWLLEADRTILLSPSREPDYTSIPATGGTLKKHTTFEEPVLSEANLVSLGEMAEALKEKLGEIGMKSPYDVELGFRKDKIWLFQVRPFVENKRAAASEFLRSITPVLAGDQLIPLNTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ98</accession>
    <name>A0A654DZ98_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024544">
        <property type="entry name" value="DUF3858"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12970">
        <property type="entry name" value="DUF3858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3858" evidence="1">
        <location>
            <begin position="663"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="760" mass="88019" checksum="46DC90798D883173" modified="2020-04-22" version="1">MRFFFYSFFFLITSLSFGQDLLITKSGDSLYVDLKTKKRFEFITYLDVGNGKIDYRIGTEKVKTYIEDYFVKFTDLMITTDGMILRSDSSLTILNYGDTVRLHEVHPSQIKSITPDYWKDQIPKSHYTYLGSFIEEQQKVLEIDRAKRYDKQFSNSGKFGEISLEEAMMTHCPIDSSAGAFILFDKGEFQYLPSGSGYFFSPGQFSRHLRIKILKPSGTRWGNWTVRSSESGNFNIMVFNLEGDVLVSEKLKAKDHYTEELVNGYYFNKMFIPDVKVGTIIDIQYLSRGMPREWQFQVEIPTLHSEISIEAIPNLRFSYSITGFHPILPIAPNRHWIAKNIPAFHGENFMSHEVNFVSKLNIQMEEASQLNISKTWEGVSKLIWDLIQPNSKNKDLRNFLEGVGALEMAPSEIIDTSFYYLKEKLKWSGVYQAVPFVSIYKPKSLGERIQAGEELNSAEMNLALAYLLEELGVRVLRVALSTRDNGILNPLYPERDKLNHLICYLPDQQIFLDLNDKYAIPGFLPENVLNHQGRIISKDSSAWIDLKTKDMKQVQQVTNITVDENFHVSASVQRRLKEYEYVEWAKVYEELQTDEAYEGTLNELYNFKIEKLNLTDEKGEHYVNQEMTLDLDDQVMVFDNELFIHPILMAEFSNNPFKSESRKYPVDFIYPIKKYYMTTITLPENAMVTSLPKPEAIKLENGFGNFTFVCSSVGNKIQVQYLMDIRKTTYTEVEYYGIKSFFDAISNKLQEQIIIAKNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH3</accession>
    <name>A0A654DZH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14327" checksum="076B6CD85B54EF99" modified="2020-04-22" version="1">MTLEQLSRLNEKFQQKASGLAELLPGSNLLTFSTTIIRTTKKLDVVLKKVLNAKSEGSFYTQIEAMEEEMDELIFMMDRLDEANRKRNIGTITDVVKAGYELVSLYSLCCDQILERKTKKQDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH6</accession>
    <name>A0A654DZH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="27427" checksum="1A8227CC19E9F445" modified="2020-04-22" version="1">MRFLVIFCVLLSILFTSCKEKDSGIIAHNRESISDFTFKGAENRFAGCMHTSERKVKLSLWAGNNFSVNKSFAVYLNNGDHPIMEGTLPLIRNDLEMNFMLAYTGFNNLIIHYPDSKVTTPVEVGIRINESTHSVYFDDTYNGYLDVILDSDESLHCPKVDGSSSVLFWVDYDPLCGAFSVDLGNQGSKNLTRYYETRPGCGAPGCATFENLDAGIYAYKIHCGNVEYNTGTIEVSGGPECKLVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV2</accession>
    <name>A0A654DZV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17118" checksum="2BC841466A07EE1F" modified="2020-04-22" version="1">MKRSLLLWMTFFVALMGCEDETYYPPGLYGYQVERLISGGEDKVWELAGLEVDGQTQSIEGCANAVELHVYQGTTAIDVYQITTCEVPDTLYYGEMTASEAGSSASNTNVFTDSLLFENGEVNYVIVKEVTSLRLKFDRYIGGVKSTYQWVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV4</accession>
    <name>A0A654DZV4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">proC</name>
        <name evidence="5" type="ORF">MARINOS108_110060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="162"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD15890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="267" mass="28614" checksum="3FC4679122CFB6C1" modified="2020-04-22" version="1">MELTDSNIAILGAGNLGIAIAQGIVEEQLKEAGQICLTRRNLDHVGYLKAKGFQVSSNNLEAVKQAKMVLLCVQPKQLPRLLEQINPGLTKDHLLVSVITGVSIAEIKSHLKLEVPVVRAMPNTAIAIGESMTCICSEDSKDDALAVQKIFNALGKTLIIEEKLMQAATVLGASGIAFFMRYLRAATQGGVQMGFHSEDAQMIAVQTAKGAASLILENGQHPEVEIDKVTTPEGCTIAGLNEMEHQGLSSALIKGLMVSYEKIKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW5</accession>
    <name>A0A654DZW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB</name>
        <name evidence="8" type="ORF">MARINOS108_120243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="7">
        <location>
            <begin position="149"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="37391" checksum="807497755697EDCE" modified="2020-04-22" version="1">MTGKIKILVVDDSAFMRLLISDLLSKDKELEVIGSASNGKEAVEKARELKPDVILMDINMDEYDGLYAVEHIMKANPIPIVILSSVGNTNLDVVFDALRLGAVDYINKPQKGGSKIREINVEILAMVKRVARAKPRPTPIESDGLSKLPHTFDSEARFHVIVIGASTGGPSALEKVITSLPANLNVPVLICQHMPPNFILSFADRLDALSSLKVVVGKRGMVPQPGMVIIAPGNANMVVMKDGKGEKVKIGFSKEEYKEYNNPSINALMESVAECYGEKAIGVLLTGMGRDGVKGMKMIRNNGGITIAQDESSSIIYGMPKIAFETGAAEKVMHIKEIGGYLVNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E016</accession>
    <name>A0A654E016_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="105"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="214"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="392" mass="44364" checksum="9AE20015000FC3BD" modified="2020-04-22" version="1">MNVFVIPSWYPSEQYPSTGIFFREQSHLLATHRPNWNVGISLWGSHEPKLWLKAYAPLGGFIKYNSKPPIRKYEIQLEYNCVEFFTPAFTWTRKFRNGNIRGIIAANRQNFERFTTHFGRPDVIHAHVSYPAGAIARALSEAYQVPYVITEHMSPFPMASFKKDIQKTVLPPLRAAGQVLAVSQALIKRLSEFGVRADRISNFLDDRFFTPGSAQTGRFTLVAVGRLEAQKNYEALLESIAHVQKTGVDFALKVIGTGSREKHLRNQCSQLHLDGNVEWLGECNQNEVRQALRSANLMVNTSRHENQPVAILEAMACGVPVLTFDWDGADELVFGDAGEVLPSDPILLAEKVKSLAQKNPYDPQKVRATFEDHFGTVAQVQKLEQYYQRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E033</accession>
    <name>A0A654E033_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="20806" checksum="E1078434D214858E" modified="2020-04-22" version="1">MLQSIILSLAMLVSSGEGTEANYKVDTKASTVEWLGKKVTGQHNGLVNLKEGSFEFKDGVLTGGTFTVDMTTIVDSDMTGEYKGKLEGHLKSDDFFGVAKYPTSVFTITKAVPQGPGKYKIVGNITIKGKTEEIQFPATLEEKDGKVTGTASLTIDRSKFDVRYGSGSFFDDLGDKTIYDDFELTVNIVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E065</accession>
    <name>A0A654E065_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE</name>
        <name evidence="11" type="ORF">MARINOS108_11218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="217"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="422" mass="46289" checksum="68DFF22C7FABD891" modified="2020-04-22" version="1">MSFKSLGLSESLLHAVNKKGYSTPSPIQEKAIPLILQGKDILASAQTGTGKTAGFALPMLQLLAEGRQQSRPVVRALILTPTRELAAQVHEDVHTYSEFLHLRSAVIFGGVNANPQIRALRNGVDILVATPGRLLDLYNQKAVSLAKVEILVLDEADRMLDMGFLRDIKKILALVPEKRQNLLFSATFSREIKQLANGILNHPVLVEATPENTTAEKVDQKIYRVDKSKKAQLITKLIAEGDWQQVLVFTRTKHGANKLGKILTKNGLTAAEIHGNKSQGARTKALAGFKKGTVRVLVATDIAARGLDIPLLPHVINYELPNVPEDYVHRIGRTGRAGASGEAISLVSLDEIEYVKGIEKLLGLKLDSEVLRGFEPTETAADIKKEPKKGSFQRSQSSKPRDSNKGNFRRSNRSNSSRNRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E084</accession>
    <name>A0A654E084_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rsgA</name>
        <name evidence="10" type="ORF">MARINOS108_120299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="76"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="85"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="180"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="305" mass="34449" checksum="DAC7CA7718370728" modified="2020-04-22" version="1">MKGLVIKSTGSWYRVRMTNGEEVNARLRGKFKLDNKKITNPIAVGDEVVMESQQDEWVINEIEERKNYIIRKSPKKKHFDHLIAANVDQALMIATLKEPRTSLGFIDRFLVTLEAYRIPGVIVFNKVDLLDAEGLEEADYLSFIYEKKVGYPCIKTSFIGGKVPEELSTLLRGKRTLLSGHSGSGKSTLINLLLPEISQKTSEISSFSEKGTHTTTFAEMFFLDGETAIIDTPGIKELGLSEIEGGELGHYFPEIREVMNDCRFHNCQHVNEPGCAVKKALEEGGITQERYYSYLSMLESDDNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A6</accession>
    <name>A0A654E0A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025063211" evidence="1">
        <location>
            <begin position="23"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="519" mass="60773" checksum="2B03264F0BC40120" modified="2020-04-22" version="1">MLMSMKGSFFVCFLLMSFLAMAQKKAPDTSSRIDQPNRIEFEMDDYGMDFNLINGEEAGLLVAVETEKRTPEGFNWTFHSLDTLLDIVWTRIYSIPFDSYLAGTEYHNGKYYLLFNVSRYRSQEFLLVEIDALTATHRRIEINTVFPIQLTFFEVIDHNIVFAGYTNLRPVLLTFDLEEQKPRVVPGFYDNNSDILDIIIDDEALMFTVIQQDRMPNRKYTIRAKTFTAAGDLIQTNVITPGDKKNLIDGASTIFYGGFQYMAGTYSKKASQYSRGLYLSKFVNGRQQFVKYHEYADLDNFFGYMNERRQQRIRERIERKRSKGKNTQFSYRLLVHDIIQRGDEYLMIAEAYYPRYSNYSSNVGRYGWNSPARFNPSFMGYQYTHAVVVSFDRNGNIIWDNSFEINDIETFSLEEFVAVSNYEDKTVLMYLEENTIRSKIIQGNEIYEGKTFNPVRLAYVDDEVKTKNPEVEGLKVWYDRAMYAFGEQRIRNENGTGGKISRRVFYINKIQYHLDDKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E7</accession>
    <name>A0A654E0E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025039930" description="TPM_phosphatase domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="30281" checksum="1E2641DCC1B79B4E" modified="2020-04-22" version="1">MKIRILIPLFIFLSLGAWSQDVALPDLTRRVTDLTGTLTPAEQNSLEQKLLNYENTKGSQVVVVLIPTTGEETIEQYSIRLGEAWKIGRQGADDGVIMLFAMTDRKMRIEVGYGLEGALTDALSKRIITNVITPEFRSGHFYKGIDSGVDVVISAIMGEELPPAVKQRSTNSTSSKSWVLPVLVLGFIFTGILKAVLTKKLGKGKATGLSAVIVFILGWLLIGLAAGIFIAIIVAIFMSVPSNGGRGGRGGGGMYWGGGFGGGGYSGGGGGFGGFSGGGGGFGGGGASGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F4</accession>
    <name>A0A654E0F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12339" checksum="76E9B5A3A728081C" modified="2020-04-22" version="1">MKYWSLILIILFQCQSRPQKSVPIERTQSSPDYRLHPDQCLVFAHALSSEGNSSVLVIEEILGRGFGFKENLNAGDTISAEGETQPGVDTLVLDFRPQMGGGKYLIGPGNSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y0</accession>
    <name>A0A654E0Y0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">MARINOS108_140053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="11"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="263" mass="28924" checksum="DF69E24FFC6DED06" modified="2020-04-22" version="1">MIHYKSKEEIELIRQSALIVSKTLALMAEHIRPGITPLELDKIAEEYIRDSGAVPGFLGLYDYPNTIITSVNEQVVHGIPTNRPLQEGDIVGMDIGALKNGYYGDHAYTFAVGEVSDDIKQLLKVTKESLYLGIAQTVAGNRMGDIGYAIQNYTESFGYGVVRELVGHGLGKKMHESPEVPNYGKRGHGSKIKEGLVIAIEPMINMGTRRVIQLSDGWTIVTADKMPSAHFEHNVAVVDGKPEILSTFKYVEEALEKVNGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E132</accession>
    <name>A0A654E132_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein with beta-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_130003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024867636" evidence="1">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="117"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="369" mass="41375" checksum="310714CB2135C71E" modified="2020-04-22" version="1">MKKIILTLICSLAMLGIYAQTCTQRLNQAEDDYEAGRLLGIPNQIRDCLDSDAFSSEEEVRARKLLTLVYIFTDQEFKAEGALIELLKADPEHRLNPQVDPAELFFLYSQYRTSPVFRISLRLGANSSDPQIIGVYGTQNTVAAPSFYNGKTESGESSYALNDSTTLSGIGGLGIGFWGELLVERHIKNGFEVGFGGQFRLSKYNVDNYLNQQDLSTSVVNQQVYLRTPLLARYTLGYSNRDKKWLPYVYAGGAFDYLLSAGYTSASRVGGTAYTQTSSDLLASNQVNKVNYSFFGGLGVKYRLKTHFLTIEARYDNSRLNYVNGEERYTNSESTFDLGYVESDLSLNFISFSVGYTHSIYSPKKLKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E153</accession>
    <name>A0A654E153_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5481" checksum="643899AF04D96D8C" modified="2020-04-22" version="1">MAFDRGYGAYEMRRVGFARGLPFLFDYSTFFIRHGRKMDFLSYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A1</accession>
    <name>A0A654E1A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024984645" evidence="1">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="27165" checksum="98F2F12C217CD2C1" modified="2020-04-22" version="1">MNQSKTILTLVLVMMACAQSFAHYMWLETSESGELGKAHAVKVFFGEYTYGVVEDPSGENFAAVKNFKLSVVTPSGLKHEIPTSVKGDAFEGIFTPTEKGTYTVTLNNDEIEVIDYTQYDFGVFKTHYHSTARVVVGGESTETKATNDKGLVLVNSAADKADVGAEVVLKVLYQGKPLAEQEVAIYVADLWSKKLTTDENGQVRFDLPWATRYTIEATKKEEVPGTYHGEEYEFIWHCATYAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A2</accession>
    <name>A0A654E1A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025070131" evidence="5">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17054" checksum="1FF3AD826F9EDC89" modified="2020-04-22" version="1">MKNFKPTLLILVIFLTSCGTSPKKTADEKPVDRRTEIRLTQYMVQGKVLYQTYCSNCHQADGTGLGKLYPPLAGSDYLMADLKEVACLIKNGKTGEIMVNGVSYNQMMPANTHLTPIEIAEIVTYISNSWGNEAGISATRDVTQWLKNCDQAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B0</accession>
    <name>A0A654E1B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane ATPase/protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argK</name>
        <name evidence="3" type="ORF">MARINOS108_120400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="57"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="35439" checksum="65BFF1794E90001F" modified="2020-04-22" version="1">MKDRSIKRPSLDELTRGIDQSDRMMLSRAITIVESKLASDQQLAAKLLDSVIHKTGKSVRIGITGVPGVGKSTFIESFGTHLTALGKKLAVLSIDPSSTLTKGSILGDKTRMTHLSQNSNAFIRPSPAGTSLGGVAQKTRESILLCEAAGFDVILVETVGVGQSETAVRDMVDFFLLLMIAGGGDELQGIKRGIMEMADALVINKADGNNLKPANQAKKAYENALHLFPPHESGWTVPVKTCSAIKNEGILEIWSTIETYVSTSTESGYLTRQRESQNVKWMHELIRARLETNFFGDPAMKDKITQITKKVAAGELGVRHAVNSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B2</accession>
    <name>A0A654E1B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="28087" checksum="8EF03EA31A3DFBEA" modified="2020-04-22" version="1">MKNLILPLVLCLLFSCDQINSLKGNKIAEEADNVVKNYYPDGELKSIYTVNELRQKHGVAKIYKKDGTLSKAFEYENGEKIKAISYYKNGNPLMEISYKNDVKDGPFKRFYENGKLESEAIFKENFPGKGLKEYTSSGSLKKHYPELIVKGIDQINLNGRYIIEVYFDKNPGRGTYYIGSLTEDTFLNYRLDEMERVNYRGRLVITPAPGVIIMEKLNFVGEFKTPTGNKYIVEKSFNLAIDNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I5</accession>
    <name>A0A654E1I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="27" mass="3203" checksum="B120FB34E422E704" modified="2020-04-22" version="1">MFNTIDDVIKNGQLFFRNGQPVIFDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L3</accession>
    <name>A0A654E1L3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="40780" checksum="45834A1B65BAD1C3" modified="2020-04-22" version="1">MLDNRRYDIDWLRVIAIGLLVIYHIAIGFQPWGVFLGFIQNSETAEWIWTPMAMLNVWRIPLLFFVSGMGVYFAIQRRDWKALLIERTKRILVPYIFGILAIVPLHVWIWKNYYHQDMEFALSPMHLWFLGNIFVYVLIFTPLFFDLKKHPNGKFQQIMSKLLSHPAGLLLLMIPFVAEAELLHPDSFEYYAMNAHGFWIGMLAFLTGFLCVYSGQAFWSTVTRWRWLMLAIAATLYTLRLLEGEFIAPLYLKSIESNLWIFTVFGFGHRYLNKPSGALTYLSQSAYPIYILHMIFLYLASWLLFPLDMPAPFKLALVILLTFIGCFAAYELVVRRIRFVRPLFGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R1</accession>
    <name>A0A654E1R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="191"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="752"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="935"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1512" mass="164053" checksum="FCB7D2474FAC3B61" modified="2020-04-22" version="1">MAAIDESGNVSYDVDTVTVTGDVAPDISFTVDENRCIANANTFTSVSSTPEDIVSYSWDFGDGEGTSSQSDTSYQYTFPGTYEVLLEIISSGGCRNLFSQELTVYPEPPTPKFTIDYSSLCTNNELEFVNTTDTAGYGDALVFEWVIGGDVVTKFDTVYTFDTPGDHQISLQVFLPGCESAITDTTISISEGPAVNFSYSNNCFGEAVQFSSEVEGSEISSYSWDFGDGEGTSSAADTVYEYATAGTYNVSLTVFNDGGCVTEYESSITVNDQPLVNVLYGEIEEDAPVTFTGEDLTLSGDSVKTWVWNIEGQEERTEQSPSVIFTSPGEYQVQLTIETFQGCTDTFEALIEVDPAACPSSEIIINSSDVLCLGETLGLTNGSVNATAYRWDFCSGELGEMPVSQLIKNSGTVSPSDMAYGNDGQNWYGFITERTNNRLYRLEFGASISNIPVVKNLNNPSGLLSSPDRILLHEEGGHWYGLMTNDQVTNNLIFLDFGVTLDNTPTATSLGNYGGKLNRPRGMSLQESGGDLILVVVNRGDNTVALLNFGTSITNTVSSESVLKSGAIPSSNVPLDLSIGKDCDSWYGFTVSAGNGNLHRLLFGNSLYQIPTFETINLGLSSLSQVELRHDGTIWRGLISGNSGFYRLDFTSGLGSSPETVSFASLGLSNISGISMLADSVGFLIDNVSQDVYRLDFDNGCSSTIKESTSYEPIEVSYGSSGTYYVSLAAIDESGNVSYDVDTVTVTGDVAPDISFTVDENRCIANANTFTSVSSTPEDIVSYSWDFNGDGIEDSSEPNPTYRYSVAGDYTIVLTIGDSSSCGNTAKKTITIYPGPPEPDFSTDQTTYCVGDGVFITNLADDSDYGDGVSYYWSTELGDTVSTSPVFNFDQPGEKTISLYSSIPGCDSEIITKTVTILPLPEIAFQADTACHGEFTEFTNFSEGTSFAWTFGDGFISKAENPEHFYTEPGLYDVTVSNVDENGCENFLAKQVIVGAIPEPEFEYDIACQGDETILSDVSIVNGADIVEWEWYIEDIPVSQDKNPGVYFDREGSQTVTMTVFSSNGCSATYSESIEVLGQPQVDFSITKACQGDFSSFVDQTKNPDQIISRTWQINGVTQASDDDTLTYAFVEPGLYEVSLMVNNRSLCTAEQVKTLEILALPELDFLIDGVCENEVITVSDQSVAINDAIISRRWLLNGGFVGNGRKIEIPADVSGLHDVTLEVETAFGCMVSHTETLEVYAKPEVAFTPANDFGVPPFSLVFENETVNGQTYKWYVNGELTSEEMTPSLSFGTEGLQTVKLVATNENGCRDSVSTEIESILPVVDLVVNEIQLIEDGGLQKILLDVSNKSNLPVELFEVQITLENEFTLSENVTKRINKGKEAIIGLSVSLPSVSKLGYLCVSLVAPYNVPDQIPENNEGCINMEARTIFEPAFPNPATDRTHIRMVLPLDGDVELTILDLSGQVKQQKNLYNRPSGLTTFTIDLQTLKSGTYFISIKHNGGTHRARIIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S7</accession>
    <name>A0A654E1S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF2 family DNA or RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="530"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="814"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="976" mass="112854" checksum="D20BBA41787CD3F9" modified="2020-04-22" version="1">MKVAPDQPFQIVYSLFEHEYLGFLFESFVVQINDKGNLTYSHQNISAQNAEEFDEGLDAADYELIKTMDQMQQKAVFNHFQKKKMKLDEFFLKVYDKKAGDKILQDEIDRYLEIRRSKVLSLIHGKQLFEMGKDGEPTWKKITISDEKATVLFHFRRNEENTHYFPTIKLKEEKVHFFQNESYLLCKEPAWMVVDDTLFTFEQEVNGNKLKPFFNKKFILIPKNVEETYYRKFVAPLIASFDVYAQGFEIKSEKLLPTPVLSFSELASASQSTGTLFDTPKTNGTSADVSKILFELSFRYGTYSYKADKLKKVSVSVEKQEDDYIFHRVRRDSTQEKSFIDTLTNSGLPLKSSRSTLSKTNAMSWLNDNLATLREQGFIIDQRDASVKKYFVGSTDFNLEITENIDWFDIKAVIHFGEFEIPFTTIRQYVLNKQSEFKLPNGEYAIIPDNWVTEYSDLFAFSSNGADNITLNKIHVSLVKDLKDGNHAKVAMTRKLEKLLDFDEIEDTPVPAKFKGTLRPYQQAGYNWLSFLNQYGFGGCLADDMGLGKTVQTLALLQGEKEKDNGSTSLLVMPTSLIYNWEMEAGKFAPGLKILNYTGTNRNKNHERFARYDLVITSYGITRIDTDLLKQFYFNYIILDESQAIKNPDSIISKSVRELKSRRKLILSGTPIENSTLDLWSQMSFVNPGLLGTEKFFKTEYQIPIEKRKDEAKMRRLNALIKPFILRREKTQVAKDLPEKVENVHYCDLSAQQREYYDREKNAYRNKILDLIAQDGLQKSQMILLQGLTRLRQIANHPSMVDETYEGDSGKFEDITHMVSNALGKDHKILIFSQFVKHLKIVEQYLQAENIPYAYLDGSVKDRKAEVEKFQNNENIRIFLISLKAGGLGLNLTEADYVFLLDPWWNPAIEAQAVDRAHRIGQTNKVFTYKFIARDTVEEKILKLQQSKLKLAQNLITIEESFVKSLSKEDITNLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X6</accession>
    <name>A0A654E1X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="11368" checksum="4BA36AF187EE2E09" modified="2020-04-22" version="1">MNMERKNRIEEVMASLEGIQKAKAPRDGFAKIQQKLADQRREQPTLSKPDYGWMKVAAVIALVVCSNAWAVSNYWGADRATSADASAYPQLVTDFNLYENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E229</accession>
    <name>A0A654E229_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comM</name>
        <name evidence="3" type="ORF">MARINOS108_20319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="512" mass="56099" checksum="363024174C223478" modified="2020-04-22" version="1">MLAKTYGSAVYGVNAYTITIEVNVGQGTRFYMVGLPDSAVKESEQRVESSIKYHGYRMPRQKVVVNLAPADIKKEGSAYDLPIALGILQGSEQVTFPDLEKYVIMGELSLDGMLRPIKGALPIAIEARKKGFKGFILPKENASEAAIVDDIEVIGVETIKEAIEHLDGTAPIEPLHHDTRDVFFYDLDQVDADFADVQGQENIKRAMEIAAAGGHNVIMIGPPGAGKTMLAKRLSSILPPLSLHEALETTKIHSVAGKLGGNGKLIANRPFRSPHHTISDVALVGGGGIPQPGEISLANNGVLFLDELPEFKRTALEVMRQPLEERRVTISRAKISIDYPANFMLVASMNPCPCGYYNHPEKECVCGPGVVQRYLNKVSGPLLDRIDLHVEVTPVSFDQMTADRKAESSLEIRARVIRAREIQKDRFKDSPEVFNNAMMGSSTTKELCKINEGGKVLLKTAMEKLGLSARAYDRILKVSRTIADLAASEDIKIEHLAEAIQYRSLDREGWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E251</accession>
    <name>A0A654E251_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein YphA (DoxX/SURF4 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="16251" checksum="2ACDCB9B9FB6E9CE" modified="2020-04-22" version="1">MSTIFSEIEHWGDAHRANWLVVLRVALGGFIVFKGAYFALHIDQLQEMSLSVAYLSVGLAHYVLFAHLIGGPLILLGYYTRTASILQLPVLLGAVIFVNAPQGLATVGGNSELWVSVITLFLLIAFSIFGAGKYSLDEMRRKEEMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E262</accession>
    <name>A0A654E262_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="PTHR24027"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024921402" evidence="1">
        <location>
            <begin position="22"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1572"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1672"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1765"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1872"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1973"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="2073"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="2172"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="2265"/>
            <end position="2365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2548" mass="272405" checksum="138116C3796963E4" modified="2020-04-22" version="1">MLSKRILYLALCTLISGAVSAQNRSIGKLIKKPVFHGQEDNPNDRMAFEVLRTQDPVTGEIPSQIYEKQLTYYNETLKPQGRRFMADNLISWSSRGPFNVGGRTRALAIDVSDEEVILAGGVSGGVWRSADGGATWSKTTGSNELQSVTGIAQDTRSGQTDTWYYITGEYAGNSAGATGASYRGDGVYKSTDGGLTWTLLSSTSTEMPQTFDQYFDYNHEVVVSPDNGNVIVANYGGIHVSANGGTNWTRTLNSTGWSDVVIGTGGNVYAHNTSGVYKSTDNGANWTDISDSGFPSFGRGELAMAASNEDIVYLLAEASANTSGHALWVYDDDTGLWADRSASIPQEGGQTGDFSSQGGYDLLIKVKPDDPNFVIIGGTNLYRSSDGFATTTNTDWIGGYTPANNSYALYTDHHPDQHSFVFYPSDPDQVISGNDGGLQYTADVQSTDNATYPITWTPLNNGYLTTQVYAVSVGPQDQILAGLQDNGTWLTLSTDSEVDWTSPFSGDGAYSAFASDGATRYMSSQNANIYRIGHTDADDPTPNSYTLFTPNSYSTSLFITPFYLDPNDDDIFYLGGTNALWVNTSASTGTASTGWKTISLSGISGVVSEFGVVGSGTTYLGTSGGQIYKVEDVTAATPVVSNISPSGLSGYVSGIGVNEENADELLAVVSNYSVKSIYHTTDGGANWTHVSGNLEENTDGSGSGPSVRTARILGDGRLYLVGTSVGMFTTQDLDGDDTSWEQEDIDQLGAVVVDHIVVRNSDNLVVAGTHGNGVYSAYMPAAPIDLAISSIDGPAGGVLGTESVVVTVSNNGTATQSTYEVSYSINDVLQQTETVNSSLISGATYQHTFTATYDFSAPGTYSISASVSVADDEISSNNTLTASVESVTTISDYPYTEGFEDGTHQWTLSGVWEQGTPAQTNISSASSGSGVIMTDLDANYGTDLYDVAESPVFDLSAMDGAELSFDIFYQTEADYDGVILAYRTDLSEDYTIIESGTANWYNGVFDALGVSGWNGSSGGYLTAATDLSFLAGEPIVQLAFYLISDYTVGDEGVAIDEFVITPIYDLGSIELTAEAIDENNENGEEIGTFSLSEGYEASYTLVAGSGDTDNDAFSITDGVLYASEVFDFETQSTYEIRVEAETASFGSVTGEFSITINDLNEAPGTLSLSSATVSENEVVGTEVGTFSATDQDASESFTFALVVGDGDDDNSSFSIDDDALKTGEVFDFETQSSYSIRVKVTDAGGEILEEVFNISITDEEEAPTVLNLSNSELPENEESETLIGTFSAEDEDLEETFTYALVEGEGSTDNTDFSIEGESLLSAEPFDYETKKTYSIRVRVTDSGEESYEEVFEVSVTNVGEVPTGLSLTGSEIAENESTGTLVGSLSTEDEDEDESFDYELVSGEGSTDNTSFALDGGNLLSAAIFDYESKTQYSIRVRVTDNYDLSLEEALTIEVTNVNELPTDILLSNSDIMERSDVGSVVGTLSAVDEDLADTYTYALVAGDGADDNTSFSINGADLVSAEEFDFETKSSYSVRVQVTDGGGEVLQKSFDIDILDIEENVTGILISDNQINENVSSGSTIGNFSVEGTGISEPYIYTLVSGVGDDDNDLFSIEESTLKSAAVFDYEEKSTLKMRVQVQVSDGGVFMAPLEIEVLDVNDVPTGVFLSDNEISENEEAGTFIGALSGEDQDSGESFTFSMVSGDGADDNARFLLEESSLYSLEEFNFETASEFSIRVEVVDSENASFQQVLSIQVLDANDLPTAISLSSVTISENMSSGTALATLAATDEDDEESFTFSLVSGDGDTDNSDFLVDGSNLLSAGVFDYETQMSHSIRLRVTDSDLASFEQSFIITTEDANDPPTAIVLSASELSENAASGSEIGVLETTDEDVDDTHTYDLVAGDGDDDNTRFAIVGDKLVSDEVFDFETQSSYTLRVKTTDGGGQTLEQSFTIEILNVNEAPTDIALSSNVIVENELAGTVIGDFDAEDVDASETFTFLLVSGDGDEDNSSFSIDGSQLQSAVVFDFEEQSTYSIRVRVMDIGGEYYEEPFTIEISNINDAPSAIMLSQDVIAENEAVGKEIGQFSTMDNDASEVFTYQLVAGNGGDDNASFSILGDALLSAQVFDFEEQSEFHILVNSTDAEGAIYQQAFTIGVTDVNEAPYGLELSASSVEENAPVGTKVGDFLPVDEDLSESFSFSFVEGEGDENNADFTLDGSALVTSGPFDFETQSSYSILVAVTDGAGQSFQSAFSIQVLDVNEAPEALSLTTSTVNENQEKGTLVGTLLVSDQDEGEVFTFAMVSGSGDEDNASFLVEDATLVTNEVFDFEVKSTYSVRLLVEDEGGAKFEQILPIEILDANDAPTDLTLSNDVIPSNQIDGYEVGVLDAEDQDNDELTFELATGSGDDHNLNFTIVGTKLQTSGLTINDPEEIFHILVEASDARGGFAVAPFDLTVEEILGLVHLAGKGISIFPNPVQEWMGVKMDNSSRGKVALAIYDLEGRRVHQSSWEKQADILKDRLDLSGLARGAYVMKFQLEDEEVIGKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E1</accession>
    <name>A0A654E2E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">cutC</name>
        <name evidence="3" type="ORF">MARINOS108_20429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="244" mass="26231" checksum="0CC449196CECB331" modified="2020-04-22" version="1">MKTIIEVCIDSIESAINAEAGGADRVELCDNLAEGGTTPSAGLIRAVSAQIGIGLQVMIRPRGGDFLYSSAEIEAMKHDIQVAKDLKVDGVVFGCLTREGDVDLERMAELMAVARPMNVTFHRAFDMVQDPMRALDMLISLGVDRVLTSGLQPTAPEGADMIAKLVSHAASRVIILAGGGVRPHNIQQLIEQTGVRECHVSGRTILESKMTYRNPGVMMGGTTHPSEYERLVVDSAVIRSFRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M8</accession>
    <name>A0A654E2M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025015666" evidence="4">
        <location>
            <begin position="22"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="417"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="660"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="777" mass="88125" checksum="5490C1FEFB4503E7" modified="2020-04-22" version="1">MIQFRYFSGLVLLCCMLGLRAQSVDNGILDLRQLGDDFSEVELDGDWFFYWNELVSPDSTDFSKAGLARFPGLWNHMEETGYSPEGYATYQLKVLINPDRKYAIYTPAVYSAYHFYINDELITSNGVVGDSEDNSSPHWIQLVEPIERGILKDTNVFTLQISNFRHSRGGPIDSIVFGKKSALLSYRNYLFTIDALLTGALIMGGLFFLGLFLFGRNHKSILYFSLFCMAFSYYIFGSGNYIMHWLFPDIPWIVTIKLEYATLYLVCILFTKYTYHTYPLDAPRLGDKIIIGVCLFFLAVAILLPPALFTRINQYFLIFIFGGIALGFYIYLTALLNKRIGAVYAFISTSMILLVLTLKNLHQFEIVDLPLFVLPAGYMVFFFLQSVTTSQQVALSWRRAKENAEASLQVKSDFLSTMSHEIRTPMNAVIGLTHHLLDSHPRNDQKNTLDILKFSSENLLRLINDVLDYSKLESGNLVLEESLLDLKSLGNNLVDGFATIAEEKKSKVVFKYDPELPTMFLGDGGRLTQVLSNLLNNAIKFTTDGKVTLSMTQEQRQPEGIFIRFAVEDTGIGISNHDKGKIFEKFNQANTSITRKYGGTGLGLAITKKILELQNVKIQLISELGKGSTFYFTQYFKIAKGFRKQVVRPSALVDPLKDKRVLLVEDNSVNVMVAKRFLEKWHCAIDIAENGLEALNQFEEDKYDLILMDLQMPEMDGYEATRQLRARGAVLPIIALTAAALSDVEKNILEAGLDDFVVKPFHPDHLYQKLIKYMVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N6</accession>
    <name>A0A654E2N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="976" mass="112017" checksum="C4EAF91160873907" modified="2020-04-22" version="1">MQELLNSLEVELEKLINDKLYTSFKSEIRNEHSDFESLQKSIFQTYENSAGLSKAELKAEILSLISQSWNASDGQPFSEFSAGYYEAVQACLQSIPETLEIPQEKDRFTALKTDSFLLKLAKGAKSIAFRASTVLVRTANLFRKTKQPIHYWNHKIPLRAIGEYYLLGEYIQSILEVRARYYTLFSKAYQELKEWEESADTAEFTRLDFSHLTKSFSKVRKDLKTELVNNLHTTTQQLRKAATTVDTLEHSPNRYEEKNLMAHLQSADGLWQKEDAGWHNTFDAFFEEWRADLEVFRLISLAESDFVTYQSAQSNNLSEDIGEELEAIFNYIHSAIADLEKSKDEDFSLTLKKCNYRAQKTLDQEVIPLLVEKLSSNQIINAVNRFEADLNRALENLTTERKIAKIPTDYLAPIAIANITTISPYELIAFEITPTFKSQLDRIKGEFIGQLDESVTVARDLDHMITFGLTAALQQLQDHPAAKEDAQKVAIESLRRSEERVRDIQTALADIIDTTNEQLRIALNDYIESLRQLTVNENVREIRMRVMRARAIQQTEAYKAEMKDSAKAYTSQVVAHAKAWLNKLKILQHDLSQRFILTSKKEAASKEVSDFLSESQEVINALPIIYRNLYRIEPLTDHELFVGRQQEYDQLMGAYANWEKGRMGSAVIIGEKWSGLTSYLNYIQHQSPFRYAVNRITCETESYGTQQLLTFLHGLLENDTAETPIQCVSALNEGPRRIIIVEDIQNLYLRKVGGFARLKDLLELISHTSKNIFWIATSTLYTWNYFQKTLNVQDVFSYHIKLQPPTAVELSNIVAKRNRISGYKILFDPSEDDLKSKKFKNLSEADQQATLKGRFFKKLIDFSESNISMALMFWLLSTKSVDQNGIVIGDFRKPDLGFLMAFDIGKVLALHQLILHDGLTLNQFTIVNRSSHQSAFLMLSMMLEDGILIFKNDIYTVNPLVYRSVISLLKAKNLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U9</accession>
    <name>A0A654E2U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketoacyl-CoA thiolase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fadA</name>
        <name evidence="7" type="ORF">MARINOS108_20241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="267"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="41881" checksum="5DE8A067C332B30C" modified="2020-04-22" version="1">MDAYIVAGYRSAVGRAKKGGFRFYRPDDLAADVIKHLVNSIEGFDPKRVDDLIVGNAIPEAEQGMQMGRMISLLSLPVEVPGMIINRYCGSGLEAIHLACARVHSGTADCIIAGGTESMSLVPMLGYKTALNWKIAENNPEYYLSMGLTAEEVAIDYNISRDDANEFAMKSHQNAAKAIADGKFKDEIVPVTVEEIYLEGDKRKKRSYVVDTDECVRADTNMDSLNGLRPAFKQGGQVTAGNSSPTSDGAAFVMVMSEKMVREYNLQPIARMVSYAAAGVNPRIMGIGPVAAVPKALKQAGLKQNDLDLIELNEAFAAQSLAVIRGLDLNTDILNVNGGAIALGHPLGCTGAKLSITLFNEMKRRQGKYGMVTACVGGGQGVAGIYEYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V7</accession>
    <name>A0A654E2V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16337" checksum="4C06B12DB2093832" modified="2020-04-22" version="1">MKAKYIQLLKSQVEKLDVSDFDLEAWKSSAVSALERVFGKADSRITHIHGLKIDYSSWALRDSNSQYKPVESCKRKGREIFNSAIEELELFGMATGKESILEAYFGPEDLKILLSESAEKKDVIKKLKKEELLQLTLKLIEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y8</accession>
    <name>A0A654E3Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin-binding protein (FBP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="180"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="427" mass="48536" checksum="3C497162E58DA1ED" modified="2020-04-22" version="1">MIDWTSNNILKINNDIDCFNTDAIDEPKVDDLRNKIEPWLTAIFQSEHFSLLIGAGLPIGLTYLADVTAQGMGRIEFTTHKDKIKAWADKSAKEFGRGIPNIEDDFRSAIELLQGLKIQGTQDAITLEKEINEQLDKFIRNIIKTEREFYKSNKYQSALNTLKSFLISFSSRTATRERTNIFTTNYDRFIELALDNAGILTIDRFVGKIKPIFRTTKLELDYHYNPPGIRGEPRYVEGVIKYTKLHGSIDWKFDVNSIIKLPLEFGVDETTNQIPISPKDFSVIYPNSSKGIDTAYFPYSELFRDFSSGVCRPNSVVVTYGYGFGDTHINRVIEDMLTLPSTHLVIISFDTASGRIMKFYEKLNPAQVTLIIGSHLGSLQTLVENYLPKAAIDRIQERLVKTLEKRGVAEQFKKDEGTQTSKPEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E477</accession>
    <name>A0A654E477_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T9SS C-terminal target domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1571" mass="166841" checksum="1C28A0DCFC625387" modified="2020-04-22" version="1">MKTNGKLSWILSNSVFRNGLTFLLILSLAFQLNAQSDGLPRGAYQMPYVRYESEDANRGGGAILYENPFFDELLTAAEASDQKYVGLPNNGAYVEWNINNTANGITLRFTMPDAADGEGESGSLDLYVNNAFVKTINLTSYWAWQYFPGSEPENHPGDRPRMRFDEVHFLLNTPVGPGDVLKIQKGAGDSFEYGVDFIEIENVGAPLSKPSGYFSVTDYGAVPDDGNDDFAAFNAALAAAGSAGTGVYIPAGRFELSDKWSVEENNIGILGAGMWYTELFFSTEAVFSGGILARASDIEIGHFYMNTINNQRFLNGQYVIYKGFMGTYGNNSSIHDVWVTHFECGAWIAGYDPPYPIDITYNLEFTRNRIRNNYADGINLCQGTSGTDVSHCNFRSNGDDAMAVWPNSDFGAPEAVNNIFRYNTVEHTYRAAGSAIFGGNGHQVHHCIIRDGHAGSGIRLTTDFPGYHFENTTQIRYFENTIEACGTSKDLWGFHRGAIEINATGGGIQNIFFENIDIINAQRHGVQIGGNGTDLQFDNISINGTGIDPYTYSYYTVALEGAAVMAFGGNGTAVFNNLSLENIELDPPTYKANENYNLIIQNLNVPLTGISLSESQIDMAVGEAEPLYVNYSPANATNKTVTWTTSNAAIATYDEIEGKVVGQGTGTATITVTSQEGNYTAQCTVTVNAAVNITASDDQADENGGTGSFTIAISEINQNITVNYSVGGSVSAGDYSANPALNGSVTLTPGNPSQVITITPTDDNEFEGDETLTVTLQSGSGYQLGGGTSASITIGDNENPPCTAPVIGYTSGGPTINQIIESVWSTAPAKGISNSTIGGIPGDYSGQWRALYDASNLYVLVEVGDATRTNDSGGNWWEDDVVEIFIDGNNSKGTSYDGINDFQLGFRWNDATVHAGGNSVQNTTGINFSMYASGSGYVLEAAIPWSTIGVTPSIGSVIGFDVAVDDDDNGGTRDAQVVSIATTDAGWSNPSIFGSIYLTDCNGAPGNQSPLANAGTDQTLASGISTANLNGSGSDPDNDPITYSWSQVSGPSATINNGSSASASVSGLADGNSYIFRLTVSDGSLSATDDVVINVNTASPTQTPYGGTPWAIPGTIEAENFDNGGEGIAYHDADANNNGGQGRTGDGVDTENCSAGGLNVGWTSAGEWLEYTVNVASAGTYDFNFRVASINSGGTFHVEFDGVNKTGTVTSVNTGAWQTWTSVNVMGVSLSAGQQIMRIALDNPNHNIDKVIITSATGNVPVTGVSVSPSSASITAGNTQQLTATVTPANATNQSVSWSSGNTGVATVNGSGLVTGVAAGTATITVTTQDGNYTATSTITVTSDGGGGSGYRIKNAWQNTYLADGGDRVTYGATPSGSSYEWELEDVGGGHVEIKNVATGEYMHIENLTGYVQCTTRTFGWYSSRWVIEDAGNGESRIRNAWQGDNYIHVENLQGHAQHGTIYTAWASAKWVLEPVSGARVLSESFIEQNEIKTVLDIYPNPVTDKLTIGFSGSIDTETVWALYDLSGSLIMKRKMTAPRMEILRGELKSGVYMLQINSQGERHTRKVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E485</accession>
    <name>A0A654E485_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4533" checksum="C46FB7F9EECB102B" modified="2020-04-22" version="1">MKVENKDVKEGGASKPCPAGTSVNHFDSKKFLKKRNPDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E494</accession>
    <name>A0A654E494_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024884312" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1093" mass="126047" checksum="9650C1B91125FF4B" modified="2020-04-22" version="1">MKGFLLTIVMVMLATVSAVAQYYHTPFGHNRIQYKRFDWYYYSTNNFEVYYYPGGQEYANEALSFLEKEFVELTDILGYAPYTKTKIFIYNSIQDLQQSNIGIGGDVFTIGGKTDFVKLQVELAYPGQAYEFKHEMIHKLSQILINDMMFGGSLAEIFQNSYLLSLPEWFIGGAARYLSYGWSQEMDDYVRDYLDRKKIKKLVKIQNEEAEIIGQSIWNYIAIKYGKSNISNILNLTRIIRNEENSISSTLGISFKDFLGDWQNYYMLQREEIEENYRGPKQEDIIAGFKNKDITLSHVKMNADGDKVAYAYHKNGRYEVNVYNLTSGRESTVVRGGYLINDQDIDYHLPLIDWQDNQTLGVLLYKRGYLYLNTYDVINGDKFQKPLNRFRQVESFSFNDNGKLAIISGDVDGQNDLFLISMRRNALKRITTDLYDDLDPVFIPGTSTIVFSSNRETDSVKVSSAKSTLEAVGNNYNLFVYNLDTTTTSFVRLTNTYSVDRKPIAKNQNEIFYLSDQKGITNLYKYSLRDSTFVQVSDFHYSIIDYDLAFNNPDKLSFMMLDEGRPKVFVESPYDLNRRIFTPQTGRQRLQQARFIAARLPQRKKPEPEPIPEPEIELTDIDSLVLPDSFFFEEEPEKDAVVLDKPKDDGLIDTDNYVFEEDVKAAFRPESFFSSYRKLERESRVIGPQPYDPRFSFNNLITSFAIDPIRGFSILLETEINDLLENHRLNGGVLTNTDLRSANIYGEYQYLKYWMDFKVRFDRNTYIIDPNVSFLRGTQEGDLIQKYTLNQVEVGASLPLTNTFRFEVFPFYANTRFSNLQWEAVIQNNTATVLAPNSMVHYGGARAALVVDNTIEKGFNIYQGTRGLIEFENYLGLNGMDKSFSRLNVDLRHYQKIHREFTLAGRLFYGRSMGANQQNYLIGGMQNWLFNSYEDQGVNDPLAMSNARDNSNILFSKFVTNLRGFDYNELYGTNALVFNAELRLPVFRYFSNAPISSAFLRNFQLIGFYDLGTAWTGKPPFTQEGSAFTKKYVVEGSAFSAELANFQNPWLASYGFGLRTVLLGYYLKVDVAHPIRDFAIGDTRIHLTLGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A6</accession>
    <name>A0A654E4A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Big_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024841445" description="Big_5 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="49694" checksum="A21CAB071ABDD757" modified="2020-04-22" version="1">MKLKLMLLVILSMALVSCGDQTPAPKNLIIISATINGAALTDGLSGVQIDSEISLVFDASVDLDQLKAHLSLEAEDTMVPVEVLLSNAQSKAQITADLSYKTQYTLTLSVGEIGASGESLQEGFMVNFTTAEDEIIRELAPCTNLSCIETLEVEDQGQSASFDFYSSHPILLENAQWETLRNAVIVVHGQNRDADNYFTYLTTALRNTELQNNTVLLAPWFKEESDANDQDFYWNTSSWREGQPSNGHVRISSFALVDNLINILVDKSRFPVLEKILVTGHSSGGLFTHVYAGANFSQSIHSAIDFEYVVANSQYLYYPNNYRYNEQAGTFFEPSDCAGYNYWPLGFQSAPSYLNGLSPEDFNGQFAGRKVVYFLGNNTSNDGALNTSDCSATLLGSTRYQRGENIFTFMNAYYPGQHAHTRSIVDGIGHDGQGMFLSQEFSILLSEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C0</accession>
    <name>A0A654E4C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="755"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="835"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="99"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="881" mass="99132" checksum="B6CCFFD30BFC2792" modified="2020-04-22" version="1">MSDPGGHRSPKWMLGFFRWFCNPDYAEDIEGDLVERFQRTAKKKGVRTAKWLFIKEILLLFRPGIVRSPAGFGEFNQYGMIKNYFKISLRNILRHKTFSALNIAGLSVGIASCLLILIYVNNERSYDTYNHQYDNTYRVLHYFGNQEEIDDFKAIANKDYMVWGNAPAAPALKDYFPEVESVFRFTSPSPWLVSYRDKTFSENNIVFADSTAFEVFDWPMIAGNPKSALNRPNTIVLTKKLAEKYFGVENPIGQTLIMDTEDPFEVTGVIDIPTNSHFSFDGMISMTTFKNMRPEIFENWGYVDFYTYFTVRPGAGMSDFADRIPDFLEKNFTASFNYDVRMEPLSEAYLYSEAGRQPGPSGSLSNIFVFTSVAIFILLIASINFMNLSTARSVERAKEVAIRKTIGSLKSALIFQFLVEAILVSFLAATVAMALVLIGHPYLEMLSGKSLPIDWLFTPRNGVLAVFSVLALGLVSGSYPAFVLSGFKPVSVLKGSFKTSSNGIWLRKTLVTLQFVLSVILLVGTSVVYSQLDFLRTHDLGFNPDRVLVIDYGYDGLVQRKIEVIKRELKQYPDVVDASASRATPGDFFPHAGTGVEEPSGEISYQSPAIYEIDEDFISTFQMNLIAGRSFSVDFPLDSSNALMLNEAAVRLYGYSNPADVVGKSFEQWGRKGKVIGVVQDFNYVSLHNKVEPLSLRYGTRENISMLSLRLNSDNYTNTLSELEEIWRQNVPHRPFDTHFLDQNFNAQYEADERFGIIFTVFSGLAVFVACLGLFGLTIFSTAQRTKEVGIRKVLGASTSSIVGLLSRDFLQLFVVSLLVSVPLSWYIMTRWLENFAYSISIGWEVFAWSAICILVTSLVTMSLRTIGTALSNPVDALRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G6</accession>
    <name>A0A654E4G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-L-glycero-D-manno-heptose-6-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-L-glycero-beta-D-manno-heptose-6-epimerase</fullName>
            <shortName evidence="3">ADP-glyceromanno-heptose 6-epimerase</shortName>
            <shortName evidence="3">ADP-hep 6-epimerase</shortName>
            <shortName evidence="3">AGME</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hldD</name>
        <name evidence="5" type="ORF">MARINOS108_20993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose</text>
            <dbReference type="Rhea" id="RHEA:17577"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61506"/>
            <dbReference type="EC" id="5.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
        <text evidence="3">Binds 1 NADP(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.20" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008712">
        <property type="term" value="F:ADP-glyceromanno-heptose 6-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05248">
        <property type="entry name" value="ADP_GME_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01601">
        <property type="entry name" value="Heptose_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011912">
        <property type="entry name" value="Heptose_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02197">
        <property type="entry name" value="heptose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="73"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="321" mass="36998" checksum="5CB8E82727A890A1" modified="2020-04-22" version="1">MIVVTGAAGFIGSCMIARLNESNFNNIIAVDVFQDEFKNQNLAGKKLRATIDREAFLPWLDENAEAVEFIFHLGAHTDTTEQDTDILRKLNTDYSKAIWKRCVDEQIPLIYASSAATYGAGENGFSDDENTLESLEPLNAYGESKQEFDLWAISQEQKPFFWAGLKFFNVYGPNEYHKERMASVVYHSFHKIIESNTLKLFKSHRSDFEDGEQKRDFLYVKDAVEVMYWLMHHRKNSGIYNIGTGEARSFNSLATVIFKSLGLESKVEYVDTPEDIREKYQYFTEADIKKIKSIGYPMDFTTLEAGVDDYIKNYLLNMTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H3</accession>
    <name>A0A654E4H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024821395" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21600" checksum="F88EEB189226C8A8" modified="2020-04-22" version="1">MKYIAAFCFLLLLGNLTNAQTINLNVPDPSSLKTAEDYKPLEETVIELLQSLTKDRYRINKSSRLEADNFVSKWLNGCPYLHMYLHQAVVMGLIEEKATYGKELFTTYHFGVALHMLMNQDKDYDGTEYEIQVAGINTMYESYIKLNPQQKSKTMENYGKLIRKNKLLEWVEKNVEFENTHGVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I9</accession>
    <name>A0A654E4I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="6890" checksum="FA57E627CF6398D3" modified="2020-04-22" version="1">MNPRTIKYLSTLGVTVVMALSAAYFYKTWQKGEPRYYFLIMAFAIALLLSYSLFKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N6</accession>
    <name>A0A654E4N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_50061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="4">
        <location>
            <begin position="543"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125225" checksum="AE115CBFE04B0C68" modified="2020-04-22" version="1">MKATCKSKWLFRVLGTLLAYIRLFFMKSLTKLAAIMTFMVLLGCTESFDQKTGTFEKLFTVVPASVSGVYFQNTIDQNLKFNALIYPYAYNGAGVAVGDLNNDGLEDIYLVSNQHSNKLYLNQGDFKFKDATQSAGVSDEGGWSTGVTLIDINNDGWLDIYVCKSASMEDEGLRRNRLYVNQRNGRFTQEAAKWGLDNNGFSTQAYFLDYDKDGDLDMYLLNHRHDFALANNLEDRHDRKYFSETSDHLYRNEGVVFKDVTLESGVRNKEFGLSAAIGDFNDDGWPDIYVANDLITPDYLYINNQDGTFSNQIRDRFRHTSYTSMGSDYADINNDLKPDLLVLDMSAEDHRRGKQNMPSMNTAGFWKMVNGGYHYSYMSNMLNLNNGNGFFTDIAQMAGISKTDWSWAALIADYDCDGFKDILVTNGLEHELGNQDYRRKLSALTNEKQTLSIDEILSTMPSEKLMNYAFKNNGDLTFDKASVEWGFDQKINSNGIAYGDFDNDGDLDIVLNNLQEEATVYENHSIGNYIRIALTGDARNINAIGAGVKVYTESGQQYQELYLSRGYLSSVSKVLLFGLGAEKVVKRIEVIWGDGSVLAAEDVGANQTLTFDKKDFKWDGELNSPMQHFFAELNPDQLGLKYEHKENVYNDFSRQVLLPQKQSEKGPALAVTDLNGDGFSDLYIGGAVGQHGQVYLQSADGNFHELPQPSFVADRDYEDNKAIFFDADGDGDQDLYVASGGYELTEGNVMLQDRLYLNNGEGIFTRSGGLPAMPGITGAVASSDFDQDGDMDLVVGGQVIPGRYPLFSESFLLENSGGRFRDVTQERAPELSNVGLVNDLLFTDFNGDGEMDIVVVGEWFPITFFRNREGHFLKEEVAGLEYSSGWWNTVREVDLDQDGDVDYLVGNLGENNKFHPSEQQPLHVYSTNLRDDDNYDMFLSKSYQGNLVPVRGKECSTEQNPFVSEKIESFEAFANATLFDIYGEQTIEGADHKMVYEFASAYLENQNGRFQVKRLPTPAQFGPTLAFEIFDVNGDGHLDVIGAGAIYEAEVETVRYDGNTGYLLLGDSNGNLRAFPDNSFFTKGNIKNMRSLEIAGSKHIILGANNSPVELFKVIDRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E524</accession>
    <name>A0A654E524_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipopolysaccharide export system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="588" mass="66660" checksum="EEA13D9B57C45CB6" modified="2020-04-22" version="1">MRRLDTLIIKSFVGPFILTTVVATFVLLIQYMMKYFDDFVGKDLGAEVFAELLFYFSLNMLQVALPLGVLVSSLMTFGNLGENFELTAIKSAGISLVRALRPIFFFVIVLTFAAFEFNNYIVPAANLKAYSLLYDIKHKKPALDIKEGVFYNGIPDYSIKAQEKFPDNKTMKNVLIYDHTSGIGNNRVILADSSKMFMIYNDKYLKLELYNGNYYSEEPKAREPVDQFYRTNFARMDMVFNLSSFDLKRTKEELFQNNRQMKNIAELTEDMDSLAYSIYEAKHGFFANAKGFFSYHLDSLEINMEKVAKKSKAQQVMEESVRSPMEDDKADDESVVESPEAEPDSMKAAMLAYVERNHPKEMTEDSLPKPKVKRPMIKEGMGAKPVKTLEKPDGGLIAANTGIQRKQPRPDGSGSITQKEQVLLDTLGWDYLNAKVEGKSADVLQTARNQAQNVKINLSSVASRVDNLSRDYRKFVIEKYKKYSQAFACVVMFLIGAPLGSIIKKGGLGVPVIVSIIFFLIYYIIGIICEKSAKEGVMDPVLAVWVADLALLPVGLFFLRQARVDAKLFDTDFYLVWFDQLKQRLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B7</accession>
    <name>A0A654E5B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024897773" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="20223" checksum="98B706ACC133042B" modified="2020-04-22" version="1">MKHRLILLLCFSCFFLMTRAQEKDENIVTIIDDLTIQWDNSAEKLRTYEGLMDYCRTKAYRDNTILLLKQIHHYDSALYRIVQSKFQTSEDPEAKATLDDINTLETDYTTGAFLMFLRQECTALNDNERNKTMDDYKKVSKELEKEMKKYVEAITKQIDVVDEHIHHLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5V2</accession>
    <name>A0A654E5V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAP-type mannitol/chloroaromatic compound transport system permease small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_60102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="18601" checksum="A8F369DF46CF5D38" modified="2020-04-22" version="1">MIRISEWIDGVNEYVGKSVSWLSLLLVVIIIIDVALRYTFHMTSSASFELEWHLFAALFLLSAGWTLHQDKHVRVDVFYQRFSDRQKAVVNFIGCLFLLIPLCVIGIGEGYQFAKNAYLMGETSPDPGGLPARFIIKSTIPVGFLLLGLQGVSIILKSLKTILSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5W6</accession>
    <name>A0A654E5W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="548"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="665" mass="75628" checksum="2C6CD9926BD3B105" modified="2020-04-22" version="1">MKPILTLSFICVMSILVTGQTITIRTERAADRAFEQFSYAKAADLYRETLKDTKDSLRLTLRIADCYRYLNLPDSVERYLRTVADQPHIDPIYHYYFAEALLSNNNYREAEYWYENYKNALSDDARTPLKLDALQHLSSFFTDSANYTIRRLDCNTPGLDFSPVMYGGGLLFVSSRTLDREWVKVDFNWDESRFLDLFYLNNATGEVTYFHESLKSKYHEGPADFYDGDTRIAFTRNNFSGKRIKRDDEGVTRLKIYFSTYNEQKQQWESITPYEHNSDSYSVGHPALNDEGSIMIFTSDMPGGAGETDLYISYKEEGKWMTPKNLGLSVNSEGREMFPTLVGQRLFFASDGMGGLGGLDIFSIDLSSDYEPTGEAVNVGYPINSSRDDFGLVANDDFSHGYFTSARIDAYRDDVYEFSFTRSEGERRGFVLDARTGQPIVQADVFLLDTVSQTEIYTRSDSDGAFEMPILSGVVWAVKSGKFGYLLSEEVLVGSDYKADVIIRLHQEPSVKMKFPIAIDALLRMYDSLANLPGADIGLNVHEDYMGMDFRVQPIYYDLDKYGLRPEAVTELDKLKGFLLDHPRVVVEMSSHTDSRAGDEYNLNLSQMRVNAAFDYLISQGVADKQLIPQGYGATRPVVDCTGRECSEAEHQMNRRTEFLIIGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Z5</accession>
    <name>A0A654E5Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="34195" checksum="D742E84943B1B250" modified="2020-04-22" version="1">MEKQNNLTLINPQTGNLAFKLYTFERNNPFDHIQRPGYYSLIWVKKGNGKLRANFSEYPFSQNSLLSFSPYEPFMLKATEPISGLVINFHPDFFCIHKHHKEVACHGVLFNNIYDPPLISIDKGTEGNLEMIISQIQIELQKPALAQYELLVSYLKIFLITASRLKTEQQADAQKVTAENEEPFILQNLKNYIETHYKTKHTASDYADMLSITPKALTKLTKVHYHKTLTDLISERIIIEAKRELYLTNKNIKEIAYELGYNDEYYFSRFFKKNTEVSPQLYRETIGFDKASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E619</accession>
    <name>A0A654E619_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="688" mass="79628" checksum="C27D0A34B1408F21" modified="2020-04-22" version="1">MEDKENKLPENLEDLQDGVQENPELTDESTTPEDSGETSEAEPEEAPKAEVEEAPEGQAAEVAKTEETPAEEVVEESPKEAPEPVAEVTANEDTQDDSASEDDSHDDDEDHGDEDDKLLESLHFDNPTKDELLAALKKVSGIEKMRVLDKALKEIKPPFDHIYEKEKEDALKNFVEAGNDAADFVYKGDDTDGQFFELYNQLRNKKQRFFSELEKSKDENLRKKNEILEKLRELVDGEESTASINTLKALQEEWKKLGQVPGAHVKSLWANYNALIDRFYDNRSIYFELKELDRRKNLEGKLELCARAEELVNLENIKEAIVQLNELHEEFKHIGPIPKEDQEPVWQRFKAASDEIYAKRKEFFDELKHDLNENADKKQALGDEAAEFVSFNSDKISDWNKKTKQLLELQKKWEAIGGLPRDRAKHINKHFWGNFKTFFANKNAFFKTLETQREENYNKKKELLEKAEALKNSEEWDQTANELKKLQNAWRDIGPVPEKYRNEVYQKFKAACDTFFERKRAQGSVQNKEFDQNLKKKEEICAMLEAYINADTIELGQVYDLLERYSEIGFVPRNAIKKIHDRYDDITNRLVSLEDLSDSQRSELETQVQLSKLKNSPHGGQKIQRKEGAIKRKLSSLESDIATWKTNLDFFADSKTADKLKADFNEKIEKATAEMEELKKQLQMLKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6K7</accession>
    <name>A0A654E6K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19423" checksum="440877E7DB28EDE0" modified="2020-04-22" version="1">MPINQSAINLLDQVKYIVRQMTSDQYVLPISTLSNATIGQHVRHLLEFFLCLQDAQLTRSLDYDDRKHDQYLQTDVKLALGVTNALQNTLQQQDKDFPIAMRANYDIEVENSIDISTSFFRELAYNIEHAIHHMALIKIGLREAFPEVDIPEHFGVASSTVRYQKSQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6R5</accession>
    <name>A0A654E6R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="476" mass="56027" checksum="209E30A39D9DE88E" modified="2020-04-22" version="1">MKSLIIFFFAILIFLSCEQTMRNLPIAPDEVVISGNIKGSFWREVKIQVVQDVLSQYQQFEYKPDSTEYFCFRFKKSTPSELQLSVGPNRFKAWVYPGDSVYLTAQIKSDNDDFIRQINFEGKKANQYKYFQNKALNPLSSEIELIRFQARDSSYEDFLLLMDSAYDLELHQFDQDTSGLGLHEDFIHYELNRLRYRHLIEKTSEPAIRRHQRFDTTGFPEGYYSYLDRVDYKDSSFQNSHLLYDFLKNAAESNIDEYIPEQVGIPRLDAFLRVLFRFSEANLVGQIREIFETKVIDNYARYDLNSFDSLRHLLASKGYDNKLLDYYAYLSDSLRSLEFTLDKNITVYTRDGEALNLSEQISKFPYTYLNMWFVGCRGCALDFEHQEYFVKKYGTEIQFLNICTSSPGERFDRFIAKFGDTGTHCFDIDHELSDQIFEYPYHGLFDSSAKLIINNVHRPSDSDLDEFLEQLLSKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7H4</accession>
    <name>A0A654E7H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Capsule O-acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="94" mass="10690" checksum="99EB7A231FFB68DA" modified="2020-04-22" version="1">MNRAELQDIRAAFQDGRAVFEDIRAVFEDNRAELRGNRAVLQDGCAVFRDSRAEVRDNRAVLEDKRAVFRDGHAVVQGNRAELQDIRAAHPNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8D2</accession>
    <name>A0A654E8D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="393" mass="44142" checksum="B6623CC2200D563E" modified="2020-04-22" version="1">MKVLERYLRKECLGLSIEDSPDGLEVKGALVWIDAEGEICMGEALEGTESILQYILQRPVLPISLGVYSEQILSAFTEDELTPEGIEKVFSEEVTNEDQGEFLINFMGSAYAFARKDSLLKLLYPLEPYKDQLVGVHLGLLNEYPLARSIHSRTTNSRVAIGRFEFDFSGNRPAGQKEVPSDLQFGDTLIDQNLVPPFCAALNALNGLGETTGYPELQHNQKDLKFKKVYLSLRYPVLGVLLALFLINATLFVFLNDTNKELRGKSSMIERLGAKQKQLQAYLLSNKDLLSDMEGKPEIAQICDMVGKSIPKALVLEQLLINPPSDRPGKKTQPPNPRVVISGKADDPIDFTHWVHQVEQMDWVEDVIFQRFQGPDLSNEQGRFNLILSRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8M7</accession>
    <name>A0A654E8M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lysS</name>
        <name evidence="9" type="ORF">MARINOS108_20958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="185"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="576" mass="66345" checksum="D5ECE7F55545CD40" modified="2020-04-22" version="1">MLSEQEIQRRNEREALMKMGIDPYPADLFEVNVSSKDIHENYERNKTDYKNISIAGRLMSRRIMGSASFAEIQDSSGRIQIYLRRDDICPGEDKSLYNEVFKKRLDIGDIIGITGYVFTTQVGEISIHVTSLKVLSKSLRPLPIVKEVEDEEGNKKTYDAFTDPEQRYRQRYLDLIVNPHIKETFKKRTQLVNTIRDFLNDKGYLEVETPILQPIHGGAAARPFETHHNTLDMKLYLRIANELYLKRLIVGGFDGVYEFAKDFRNEGMSRFHNPEFTQVELYVAYKDYNWMMDLMEALVEQIAINLHGDTKVQVGPHEINFQRPWKRFTMFEAIEHFTGIDISAMEEAELRETAKKLHVSVDDSMGKGKLIDEIFGEKCEGQLIQPTFITDYPEEMSPLTKKHRSKPGLVERFEAICNGKEIMNAYSELNDPIDQRKRFEDQMELAKRGDDEAMALDEDFLRALEFGMPPTAGVGLGIDRLTMIMTNSNSIQDVLFFPQMKAEKKAKIVTDAELMALGIRADLLPIIRKLALNTIEQIKHSDVNKLHNDVCGTRKKLKLNDVQNPTKEEVQSWIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8Q0</accession>
    <name>A0A654E8Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="20017" checksum="90BD6EB72434547D" modified="2020-04-22" version="1">MEMVYDLLKITIPGLLILYTAYLIVRSFMNKQLDELHLSLRHKNQEVVLPIRLQAYERICLLLERISPNHIIPRLNEKDLSAKQLQGALVSEIRSEFSHNLSQQVYISEEAWIYVTGAIEQLISLINESANELDDSATSLDLAKMVFEKNMRNQQDTLRGALSFIKNEIKELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFK5</accession>
    <name>A0A654EFK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SASA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="33228" checksum="F06E646A49F76846" modified="2020-04-22" version="1">MKSLIHLILVFIPLFSFSQETVRVFYLGGQSNMDGYGYNKDLPDSLSGSFDNVWIFHGNLAGDGEPNGGQGIWEVLKPGHGVGFASDGKSNQLSDRFGPELAFAKRIQGLYPGEKIALIKYSKGGTSIDSLGAGPFGSWEPDFRGKGGINQYDHFLATIRNATQVQDIDGDGVNDLLVPSGILWMQGESDGDKTEAMANRYYANLKRLMDLVRAALRVDDLPVVIGKISDSWNDEDGKVWDYGELVQYAQEKYARTDGNAAIVRNTRYYGYSDPWHYKSENYIDLGKAFADALYQIMGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSQ8</accession>
    <name>A0A654DSQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17541" checksum="70857717268E9A6C" modified="2020-04-22" version="1">MKSTKTIASSWDPNKHLLTTQLSGEVDQADIAYWEQSLHDALGQIDDDSFFKIFINIHGFKAIDLEAHKRFRAIIPLTLAQYGWKVGYVDLFEEEARHISYTHTRGIRCVAAVHAHQDASKIERYEAEFSREAEHFFTDASEARAWIEGFIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT29</accession>
    <name>A0A654DT29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="21714" checksum="3FADF47D60AB3B28" modified="2020-04-22" version="1">MARLFAQERSLDTLNTADTAVYHDQALYQYGLYLEPLIEVTPGPEGPYACDQIGFGLSYRRVSGGVFLSTFKGHYEKTLVFPNSFKLEYMFGGGYLGMQVLRINQFELDIRLNYGHGDMIWERTDSRADFSRDEFDLIKPEIQISGVPFRYLKLFITSGYRKIYNLSLTGTDSGEFSGFTAGFGLKAGYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTN9</accession>
    <name>A0A654DTN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045534">
        <property type="entry name" value="DUF6428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20001">
        <property type="entry name" value="DUF6428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17291" checksum="9DAE3F6D74D58A46" modified="2020-04-22" version="1">MKLSEIKSALSEIQEVKFRLPNGEYVPSHFHVTEVGSIQKHFIDCGGTVRKETVVNFQLFTAADYDHRLSAQKLHAIIELSEKHLGLEDSDVEVEHQGETIGKYGLEFQNGSFQLTNKQTDCLAKEKCGIPVEKPKVRISSLVAQENACTPGSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTQ4</accession>
    <name>A0A654DTQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl oligopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="33"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="492"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="707" mass="81124" checksum="0BCD7A7AD3F8E6BD" modified="2020-04-22" version="1">MLNMLRLPYLPSLLLSSIILTSFSINSQSLEYPPTIKRPTINEYHGYQVMDEYQWLEEIDRPEVRIWVEAQNDVSQKHLRKLANRNNTINMLNEYMLQKKRWNTYANINFSSNHESNYRLFYDDDLSAPSIYYRERSFNDYRVLVDPKFISNNDRIVIENFAPSKDDRYLAYLYSRNGSDWREIKIQSTEGSVSPPEILTGVKFSNVSWLNNGFFYKKYQQGAITDQTLDSEVYYHRLFTEQEDDSLVFKTNSPYDDFQLSGTYQQDMYVLEIHNPIKNQYSYLYFDPTSDIKAFRPLHYKVNYSLEFIDFKHGHLFMEATIHNKSQIIAFTAQKPLEIRRVTPEYEDAQITGYELMDDKIVVSYQALSKPFMTVVDLEGNILKEVDLPGGVSVSNMSYQKASGDFIFLLQSFTIPPVVCKLDLNNYDYSVVERTGVNFDFQSFKFSTQYFPSKDGTMIPIFIVYKNELKKDGKTPFLLSAYGGFGVISNPHYDPGIIYFIEQGGAFAFVHARGGGELGFDWWKNGRLDQKQNTFDDVIAAAEYLIDEKHTQPAKLGFIGSSNGGLVAGAVLTQRPELFGAVVIKVGVLDMLRYERFTVGPKWVKEFGSASDSLQFLNLASYSPYHNLKEGIEYPPTLLVTAHTDDRVPPLHSFKFAAALQGLSGSNPALLWTQQGTGHSGAANVSEKVENKAFVYGFLHEHLLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUA1</accession>
    <name>A0A654DUA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="15798" checksum="BD4FBBBD821B5A30" modified="2020-04-22" version="1">MKNLTITLTAPGNIKLAFYLGTTLLLIALLSSCQSSAQSPEYRTVTNEELVTLLKDESVQLLDVRTPEEVAQGVIAGAGHIDIYDPEFDNKLSQLDRTRPVAVYCAAGGRSAKASMKLKESGFQKIYDLKGGYRGWQQAGFPVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM7</accession>
    <name>A0A654DUM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="454"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="552" mass="61903" checksum="463514E97164452F" modified="2020-04-22" version="1">MKPSTQYTKSGRINIAYQVFGSGTIDLVYIPGWVSNIDWMWACPELVHFLYELGKICRVILFDKRGTGLSDRVVELSTLEERMDDLRAVMDAVGAEKAILFGHSEGGSVSALFAATYPNRTISLITFGVFAKRRYAPDYPWAPTDEQRQQVYDMIENSWGGGEMNLETLAPSKAKDPIFMDWLANYLRSGASPSAALVLTKTNTEVDIVDILGSIKVPTLMMQRTNDVDVKIEEGRFIAQRIAGARFVEFDGDDHLFWAGNTEEVLNEMKAFILNVKPRPNYERQLFTIMAGRILSSNKGDNELLQLINRLVVQYRGKVIRFNQDTFIASFQGPSKAVHCGIALIDTFESLDLKVCVGVHIKEMPVDQAHFISNETGSFVTSMLKQAGPSQILITQTVKHLLSGAGLNFAQHNTVFETTTANHLLLYSVTDQLNYQNEYTSQPTLARQNDSFLENILQCIESHMSNEKFGVDMLCKEVGISERQLQRKLKSITNKSPNQMISSVRLHKAKELILSNHEGIAEVAFQTGFASPSYFSKCFKREFGHSPSDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW2</accession>
    <name>A0A654DUW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21942" checksum="25B2066511764629" modified="2020-04-22" version="1">MSFRHPLILASNSPRRQELLKQAGFSFDVFVRDFDESYPEELPAEQVAEFLAVKKNKNYRELLSDQVVITADTTVVLGHLVLNKPADHAEAFSMLKSLSGRTHRVICGVCISSPKKQVAFTEITEVTFGHMTDEEINFYIEEYQPFDKAGAYGIQEWIGQTKVVSIKGSYFNVMGLPTHRVYEVLKSEFQDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY1</accession>
    <name>A0A654DUY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14747" checksum="20AAED844E9B0BF7" modified="2020-04-22" version="1">MVDDVAQQLEFIKNVFQVKPTEDLGQNPDGHTEIKLGDTTIMIGQGRPQWPSRQSMNYIYVESVDEIYKRARQFGANILLEPTERYYGDRECGFEDNQGNQWWCATYKQTLSRDEMNKRFETNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV26</accession>
    <name>A0A654DV26_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="5789" checksum="02E05560C0D7DA37" modified="2020-04-22" version="1">MVSATITDMAGRQLIHQASFEHSIDISQLSGGIYLLELKSNGFWMKQKFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV41</accession>
    <name>A0A654DV41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="27904" checksum="216297437C190AE0" modified="2020-04-22" version="1">MKLGLVLSGGGARGIAHLGIIQALEEEGLSFHIVSGSSAGALAGGLYCAGYTPSEICGFIEKTNFLTTFRPSFNWRSLLNIERASHELKKYFPEDSFEALKIPLCVSTTDIKRGKVKVFKKGQLIKPILASCSIPVVFDPIVIGKRTLVDGGILDNLPYASIQKSCDKIIALHCNPIDKGYELGNWRDLMERSMMLTVTQNVHSRKKHCDVFLEPPGLSKFKVFDFKQAQAIYKFGYKYARKAIKEGALKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD4</accession>
    <name>A0A654DVD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Big_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044048">
        <property type="entry name" value="Big_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19078">
        <property type="entry name" value="Big_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_12" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2126" mass="222383" checksum="3B330B849D871823" modified="2020-04-22" version="1">MAEESAAYTHDNDGNGQLDSISVYFSEPIVNGADGTMDFVLGATFSGRTLTAVSSGVDSVAVFTFNEVGIYNTDSVPTIDYSGSANLLDASGNGYNNFNTPFTPTDAAAPVLVFAISLDKDSTGVVESIELEFSEPVDTVILKANLADWVVSDSRRGTSVAINDFENLVDSISGTNVFGDRFYTLLISPEDTDLGTGDLLLDYSSGAAIYDSTGLNILLDITSFSIEDRAAPQILSESRSPAVNSYIDVVFSELISGSGTGGSPSLGDFDLEFDVNAFGSGTATDITFGSNITDINDALLSAPEDTVRFSLTQSGSANGNEGVRIFAQSQTSIFDNYPSYLYDSTAFVQMANVLGLGFLKDSVVLTSVTNGPDGAVFFWFTDDVDRESNSSDNNDKEIRLYTDDLTANEEIWFRFIDPDGSISFDTDTVTTMTDFAGAVLDGDNSNSLYEGYDRVRFNLGSYTGAFSGDETLKIFAYDDGDASNFKIYGTTTGIEFPQADTLFVSFPDKFAPTIVQTVAYDTDENGYLDEFVFEFSEPIVDDSVKFADFIIGGYNPIDTVASGLIQNAYDPGLYNDKFLTFSVNIAGTATDTLTVTYTNNGFLADTASNLLLTDLAISVLDSAAAIIHSAYTADENSNGHLDAIYVRFSEDIDDPGGFGGFSLSDPIRSITGATLIGGDSIKLDLTESAFYDTDSIPDITLNAGFINDAASGSVVTVGVQNFTSTQDFAAPTIANLISLDLNADGYSDAIEVEFSERIQDLDFLDVINDFTVSSDNFVTSDKIVQFSSRVDSLTGVTTNVANDKYIRLRWTPVNTVGTGQYKLSYVNSLGDITDQSANQNLFKDTTGIEVVDKASPTILSAVSLDSVNVDGNVETVEFRFSEPVKDSDFVLPSIKNFTFSDDSFVTADSASIFSTSVHNITNGVVTNVTDDEYATLIFTPSMVEGTGVIQFKYADPSFGLIHDTLGVAISPIAVSNITDKATPYFLELNTREATANTVIDSLFKSGDRIYIYADLGETGLKVRADLSNLNGSFATNQLLTDNGNNTYTFTTTTVNNMDETPGSFHQIPITVTDANSNSNTISDSLNVYIDYTAPTAVISSPESDSTNLTSIPFTVTFVEKVLNFDDSDITLSVGSVSAFDNTANPVFTFNVTGLSGTNELTVDINASVCTDTAGNANSAAAQFSIISDLDSVTAVITRNAVSSGSPTRTNDDAVSFDIAFSEPIIAGNFTIADDITITSAATVGGSNLVNDGDNQNFTLNLTTISSDGDITITIKNAGSSPITDVSGNTMPTDEGPSDAFTIDNTAPQATALTIASNNSTSLDSAVTGNVITLSLTVDNPLSGLPTVSFTSGGDAIDNSVTVNQIDPTNYTMTYVVDALDTDGAVNFSLSFTDAAGNPIAAPLDNTDLTGGDNTVIVDNTRPTVVITRNAPLAANGTVNGTNASSVSFDLAFSEGITDLDLSDITLNLGGATVGGSGTSGLASGFGANVSLTTDVAYSDFTLTVSNVAGNGTLGITLTASAFTDHAGNQMSANAVSNTFTIDNTLPTVVITRNAVSSGSFTGTNDNAVSFDIAFSEPILVGNFTIADDITITNAATVGGSNLVNDGDNQNFTLNLTSVSGDGDITITIKNAGASPITDVSGNALVADEGPSDAFTIDNTAPQATALTIASNNSTSLDSAVTGNVITLSLTVDNPLSGLPTVSFTSGGDAIDNSVTVNQIDPTNYTMTYVVDALDTDGAVNFSLSFTDAAGNPIAAPLDNTDLTGGDNTVIVDNTRPTVVITRNAPLAANGTVNGTNASSVSFDLAFSEGITDLDLSDITLNLGGATVGGSGTSGLASGFGANVSLTTDVAYSDFTLTVSNVAGDGTLGITLTASAFTDNAGNQLSANAISNTFTIDNTAPTLQAAVKNSNTQIRVEFSEVVLTNGTNPTDFTVVDEDGTPFLVSGQADGSAGDLYIVLTVADLTNAEGDLLVTYTNSNGEIYDPSQNQAPTSGAITIDLTMTEVVTLVENAANTADGDVNGDKKALYRTSGASDPSAEIPVVITPAISGSTITIYRDETMLDPVGAPYTNVTTNIQPTVADFMVEEVIDFAGTDDNGVFTFYITETAVKWCFKRGAFSKIFNSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVH2</accession>
    <name>A0A654DVH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024846494" evidence="1">
        <location>
            <begin position="23"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="478" mass="54843" checksum="08851088DA551919" modified="2020-04-22" version="1">MNVKWIKAASIIFLACSTFSCATYYQINSEFNQSFEQGNLEAAERVLNSNKQAAKKKAQFLYFANQGVVNSMLGNLEESNEWLEKAYLFGEDYQKNYASIAASFLVNPNTIVYPGEDHEHLLLLYYKALNFLKMKDYESALVECRRLVNRQNELSDKYKSDNKYKEDAFVHNLMGIIYEASGEINNAFIAYRNAYNIYEGDYKRLFGLDAPNQLKQDLLRAAHLNGFYTELDFYERKFNLKYSPVASQELVFFWHNGLGPVKSEWSINFTAVDGGDGFVTFVNDEHNFSFPYAISGPDQKSQLTDLRLFRVAFPKYEERKPYFQRAVLETNQTRYPLELAEDVNAIAFKTLEERMMQELAKGLLRAATKKAVEMAIRGPQGDSGEKKTEEERREEAIREGLSLMVGIFNASTEKADTRNWQTIPHDIYYSRVPLNTGENTVTLKTISSSGATSTQDFSFTAAKGETLFHSFQSLEYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR7</accession>
    <name>A0A654DVR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="358" mass="40762" checksum="6F96E138907E1383" modified="2020-04-22" version="1">METGRILEIVTVLVLSSYFPILTYSFFRYRLTRKQQELELLLDRVNLLKNQPGAVKEHMAREFTSRDYFLPVTFVTFITFVGMVILLASWVIYGLPGADNPDGYRSVIFSGSAFWETASVYSIEKRNLAVVAFSIMGSFIGASQYIYRRFSTIDLTPGNFFSVGIRMVNAALISLMLAFLSKDIGLSEGNHILAISFLVGLFPERGMRLLLSKVKFFPKVEDEFKNRPVEVVEGISALHKQRLAEVGIDNVQNLAYFNFLILIIKTPFPVQMLLDWTAQAKLVVEFQHEFELLQKAGIRNVLDFLDALQNGANRLEEIAQITGISRLALEVNHENLRNDQSVQLLVHFKSELETFRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW00</accession>
    <name>A0A654DW00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="118" mass="12557" checksum="9196E7B9FF2AF442" modified="2020-04-22" version="1">MKSLGFIGKLLFALPFAMFGFFHFMNASAMSGMVPSVFPAPEAWVYLAGLGHILAVVAIIIDKKAKLATMLLGIMLLSFALLVHFGGFMDGDQGDTANFLKATSLAGAAFFMSSKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW01</accession>
    <name>A0A654DW01_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TonB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_11229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
            <orientation evidence="1 9">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="269" mass="30563" checksum="AE566CC220257A29" modified="2020-04-22" version="1">MKTLTPPKPHVDPHEGGLSEAIQANEMLHKQGRVNQYQGLLDLKRSREKMDAERRPLFFFIGLSLSLLFAVIAFNWKIYDETQMVDLGDVSSDFDEILEVPPSLQSPPPPPKRVEVFVLREIDDAEVLDEVKFDLDVELTEDMAVKDVMYDVVLEEPEEEKAEEIFQIVEDQPQFPGGLKAFYAFVAENIVYPDLAKRLDISGRVFVRFVIEKDGSITDVQVVKGIGGGCDEEAVKVLENSPKWIPGKQRGNNVRVYMTVPILFLLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW11</accession>
    <name>A0A654DW11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="76" mass="9001" checksum="F0852DDFBAA1E490" modified="2020-04-22" version="1">MREITRSQLALRNGQDKDDIWIAYQGRVYDVTISRMWRDGKHYEHWAGQDLTDELPDAPHTEKVFERFSQIGILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW17</accession>
    <name>A0A654DW17_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">MARINOS108_11272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="193"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="508" mass="56457" checksum="849079C9139A0A42" modified="2020-04-22" version="1">MTDKILILDFGSQYTQLIARRVRELDVYCEIHPFNHFPDPDEFTKGIILSGSPCSVLDEGAPDLDIKALEKYPILGICYGAQLLAHKHGGEVTRSEHREYGRAKLAHINAHFDLLKEVEIGSQVWMSHGDTITQLPEDFQVIANTESIPVAAYKVENKPIYGIQFHPEVTHSLDGKTLLRNFVVHICGAAQDWTADIFVENTVRGLQAKLGDDKVVMGLSGGVDSSVAATLIHQAIGKNLYCIFVDNGLLRKNEFEQVLESYEGMGLNVKGVDAKEEFYEALKGLTDPEDKRKAIGRVFIETFDRESHKIKDVKWLGQGTIYPDVIESVSVNGPSVTIKSHHNVGGLPEKMNLKVVEPLNLLFKDEVRNVGRALEISNNILGRHPFPGPGLGIRILGDITAEKVRILQEVDDIFISGLKEANLYDQVWQAGAMLLPVQSVGVMGDERTYEQVVALRAVASLDGMTADWVHLPYEFLAEVSNKIINKVRGVNRVVYDISSKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW49</accession>
    <name>A0A654DW49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T9SS C-terminal target domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.606.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016119">
        <property type="entry name" value="Br/Cl_peroxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025068862" evidence="1">
        <location>
            <begin position="25"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="721" mass="80459" checksum="603D9CFC9E8EB0EB" modified="2020-04-22" version="1">MMKLLLCYLLLGGLLVSTATQVIAQHSVARQWNEVVLDAIRKDYARPTVHARNLFHISAAMYDAWAAYELQASPYFLGRMHSGFHIPFSGVHIPENVTLAQEEAMSYAVYRLLEHRFVRSPGILLIKEEMDALMESLGYDPSDESTDYVDGSPAALGNYIASQMLAFGDQDGSFESAGYKNQFYAPVNEPMVPELAGVRKMSDPNRWQPLAFGAFVDQSGHVSYNIVPEFLSAEWGYVIPFALNKSHLSIKSRDHQTYWVYHDPGAPPKLDIKSKEKSADYVWSHEMVALWSAHLDPTDGVLWDISPGAIGNLDIRNFPATVDEMKTFYDAREGGDHSAGHLVNPITQQPYVPQMVPRGDYTRVLAEFWADGPDSETPPGHWFTILNYVNDHPRFEKRYQGEGPVMDDLEWDVKAYFTLGGAMHDAAIASWGIKGYYDYIRPISAIRYMASLGQSSDQTLRNYHPAGIKLAPGRVEVVKGNNDPLSGQQGQHIGKIKLYAWRGPTFIQNPDTEDAGVGWILAENWWPYQRPTFVTPPFAGYVSGHSTYSRAGAEVLTSLTGSAFFPGGMGEFVAKKNEFLVFEEGPSVDVVLQWATYRDASDQCSLSRIWGGIHPPVDDIPGRLIGEKVGKRAFEVARSYFQGVTLGVKPTEPVGLPNPVSPMSILAIPAGCQEVIIYDLNGRLVRVFSEGEPLQMPAREGIYLIRLQYSQHMQTMKMVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW94</accession>
    <name>A0A654DW94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="15943" checksum="0B9406FCDD8B797E" modified="2020-04-22" version="1">MKNHLDHIDKTSLPFEVPEGYFDQLPNRISEKVSQAPTATHAAFRWALLPAFVVTALVCLVILNTANKPDRSADLLASLTNEEIFFYLENTEISEYEIAALSAEPEALLRGVDIIDQMDLDEDDFNQLMEHYDSNDISQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWA8</accession>
    <name>A0A654DWA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="189"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="369" mass="41349" checksum="D7C663665AD1EAF2" modified="2020-04-22" version="1">MMMYKFLLSLGIMILTSFQLLAQKEPVKVGVVGLTHTHVHWILGREDRGDIQVVGIVEPNRDLAKRYSEQHGFPMSMVFDSMDEMIDRIHPEAVTAFGTIYEHLEVVEKCAPLGIHVMVEKPLAVSLEHAKKMEALAQAHHIHLLTNYETTWYPSNHKAYELLKSGAVGDLRKVIIRDGHKGPKKIGVNDEFLDWLTDPVQNGGGAIMDFGCYGANLMTWLQDGQKPNTVTAITQQLQPENNPKVGDEAIIILTYDDSNAIIEASWNWPIGRKDMDIYGLNGAIYADNRNQLRVRMAEGYDGYQEESHQLEERPAPLNDPFALLAAVIHNEVVLSANEPTSLQNNMIVMEILEAARKSAETGKTITLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWC9</accession>
    <name>A0A654DWC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="240"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="36082" checksum="586C866BDEC417D3" modified="2020-04-22" version="1">MRKATITGIGSYAPEQEIPNSYFNTLLGEDVDTWLRQNVNITTRRWCKDDESVADLCEEAARQAISEAGLVPEDIDLVILSTDTPEYVSPSTASVIQDRLGLKNAGTFDLNTACAGFVTAMDVAAKYIAADERYQHILVIGGYAMSKYLNKHDKKTVTLFADGAGAVVMSATTEAGKGFLASDLKTEGQYNGWMGIYAGATHQPVTETVLKNHDHQLKFVHKFPKELNPKMWTEMARDICERIGVVPNEVDHYFITQLNFNSINETMDNLGVSRDKAHMVMDKFGYTGSACIPMALHDAHLQGKLKKGDLLLFIGSGGGLAFAAAAIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL3</accession>
    <name>A0A654DWL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="29664" checksum="8D44FA0B7931A56F" modified="2020-04-22" version="1">MIVLLLEFQLNFRHQIKHPKPKMEAYVRRTDLKDGITEIEFFHPQHNALPGVLLSELAEAIHSCGKEDQVEVIILKSGGDRTFCAGASFDELVQIDHLEAGTVFFSGFANVINACRKCPKLIIGRVQGKAVGGGVGLAAAVDYCLATDHAAIRLSEITIGIGPFVIGPAVERKIGLAAFSQLSINATEFQSAQWAKEKGLYAEVYADAEQLDQGVMKIAASLAATSPEARAALKKMFWEGCEHWDSLLAERATMSGQLVLSEFTKKALNKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL9</accession>
    <name>A0A654DWL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="590" mass="67580" checksum="C66F07F4F9ECCE76" modified="2020-04-22" version="1">MSVTQQEEIRNTQQYELPVKKENRSNGYDIYPTHNIGAGLIFEGYESLARELANSSHVKIDGYVGVLFEDLKQQLDSAFEKIDIRPKWVNVKDAMFPEEEINDKVGPFLGGDDPVFGKLTCLELIDFFNSDQLKTLASENTVEPIIFYGVGASLIPVDGVNVYFEISKSEIQFRSRAGSVLNLGSSKPADPKVMYKRFYFVDWVVLNKHKERVKNEIDLLVDGQRSQNITWIKGNEWRKTLAKIVEEPIRVRPWFEPGAWGGTWIKDKIEGLEQDVVNYAWSFELIVPENGVIIESSGLMLEYSFDFLMFMAGQKILGTDYEEYGFEFPIRFDFLDTFDGGNLSIQCHPQLDYMKKNFGENITQEETYYILDCQNDAKVYLGFQEGVTPAAFQEALENSQKNKETIKIEEYVQVFDAQKHGLYLIPPGTIHGSGTDNLVLEISSTPYIYTFKMYDWLRLDLDGNPRPLNIERGMDNLDFERSGASVKDELISKPYLLDQTENWELYHLPTHEKHLYDVHRYVVNSEVTINTEGKAHVLSLVEGGQIRVTTKNNSMIFKYAETFVIPAAANQYVIENLSQTPVLVVKAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN1</accession>
    <name>A0A654DWN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="106" mass="12468" checksum="785797A9C092F1B6" modified="2020-04-22" version="1">MNTDRIRQLEKFIEDDPNDPFPKYALALEHLQENKEKSAQLFEELLKNHSKYIGTYYHAAALYSELGDRKRAEQIYLAGIEIATELNEAHALKELRSAYMNFQFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU0</accession>
    <name>A0A654DWU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="31189" checksum="BC800F75CB855A18" modified="2020-04-22" version="1">MDITPFKSIAGNYKTIFFDAFGVLKNHRGLIPGIENTFRFLEENGIDYFIITNDASRGPRELAQDYQERGLKSITKNKIVSSGMLAREYLQYKVKSGTVAYLGTARSAHYIETLGLQTISIADLNLENAEDISALVFLDDEGFDWANDINKTINLLRAVNIPTIVCNTDKSYPVSRSEVAIAIGGLANMVEDIVGKRFIRFGKPDAQMFIFAYEHSIAEGGIADKDKILMVGDTLSTDIIGGNKFGLDTVLVLTGNTLAKHAEMRINSRGIIPTYVCESAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU5</accession>
    <name>A0A654DWU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="26583" checksum="009AAD9F7EC78714" modified="2020-04-22" version="1">MRKFIPLLLLWSCQTSEPAQKILDSHRETVGETSNIRSLTTLSNCMGPEGQYTTYTASSFTDDYVLFQQDYTYKPNPFYALILTKDEGYGLDENMVIQGPLSKPIIAVLKAHEFHEVMLQPESRYFNMRLLEDTTFFDQKCHQLIASDHLGLPVRLYFDQKSRLMAGISQVNPYKKGEIIQVHFEKWNKKNSPVIFEQLTILQGSETYTFDYESVDFSTQSIVKMTFGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX5</accession>
    <name>A0A654DWX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="322" mass="34681" checksum="A443E75FF918E459" modified="2020-04-22" version="1">MITKSILVNQFSASLDLTFTETDFPRFAQDEVLIKTAFCGVNFPDLLIAQGKYQFRPDLPFSPGQEVSGEVVAVGTWVDHVQVGDRVMASMGWGGFTELAVAKGSNTYLIPPEVSLKDASAILESYATALYALKDRAMMKPGETLLVLGASGGTGTAAVQLGRVFGSKVIAVASTEEKRAFCLQNGAHEVASPGEELKEQIKELGGADVIFDPVGGAQSEAVFRTLKPGGRHLVVGFASGEVPSIPFNLPLLKSASIVGVFWGAFWRNAPEDNRRNVLMLLRWFAEGKLSINVTKTYPLADAKKALEDLMNRRVSGKIVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ0</accession>
    <name>A0A654DWZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="344"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="842" mass="93488" checksum="B042C534A7933202" modified="2020-04-22" version="1">MIYNMLKVSWRMATRKTSFTLLNIIGLSVGMMVCLLVGLYVHYEYAFDAFHKKSDRIYRINQSMIWGDWASQMPTTGPNVALALKADVPEIEAITRILHPEGFVVTSLNEASQPNSFLEDDLLIADPDFFKIFSFPMVEGDKSSALSKPNQIVITEKAAIKYFGKESALGKTLQLRGTILEGRQAGDNTPLNFTISGIIEDIPDQSHIQFDMVASTASFIDITQNESLWTWTAFANYALLKEGVDAAQLESALKTIPPKWAASTLLRIFGLTFDELHADNKSWDLFMQPIGDVYLGSNTMGNILGPLGQRSTIASFTAIGLLILILSSINFMNLSTAQSSNRAREVGIRKALGAQRKTLIAQFLFEAFFLVIISTLVGIALTGVLLDSFNHFSGKSINLFEQLSQPVVLISIIVFCGFLGLLAGSYPALYLSSFQPANGMKGILSMGISGKGIRNALIVFQFTISIGLIIGSVFIARQLNYMTQFDLGYDKEHVLQLHNVEQFSADSQVLKNTLMSQTGIQLVGEAHQSPPNVMRGNLISARLTDKDQMEISRMKVDAPYLDLLDVALITGRNFNETMVTDLHHSVILNAEAVQMLGWGTPEAYSKESPVGKYIYSNGQKMEVIGVTADFYYKSPKHQVEPLVIYHIDNKYLPDSGTSPSVLSLRIDPNSIHSTNEMSALVASIRNEVKNLDPYFPFEYSFLDQEFENSFRNEQRVKRIMNAFTLMALIIACIGLYGLAIFSAEKRTKELGMRKLLGASVLQIVTLFSRDFTKLIVIGFLIASPIAWYFVDTWLSKFPYRTSINLWVFALAGAAGLLISWITIGLQSVKVATKNPVEALRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ5</accession>
    <name>A0A654DWZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="7499" checksum="D05D6230D64C3578" modified="2020-04-22" version="1">MQPCPKVFSAFIIPGNTGSIDHTPGRLADDDYFAMDTGGEDRVGGMRQVALANRAFSNVTQECFHGPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY04</accession>
    <name>A0A654DY04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23657" checksum="7483EB5F53FF7C39" modified="2020-04-22" version="1">MQTQNLVYPELQMTIEKAREQNISDERLAVLKPMIEYIQTKIDQGKEVNLNFICTHNSRRSQFSQIWAQTAANYFGIPALCYSGGVEVTAFNERAVASIKRSGFRVSSKGDSNPIYLISHSDDKEPIKAFSKLFDDPINRADQFAAVMTCSHADENCPFIPGTEKRIPVRYDDPKEFDGTPEEAERYDQRSMQIASEMFYTFSQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY37</accession>
    <name>A0A654DY37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="293"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="2">
        <location>
            <begin position="641"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="737" mass="84040" checksum="ADEAD3931A7FAC6D" modified="2020-04-22" version="1">MSHSKSYCQLPFGVTFLILIIATVGCMQSPRVSDDFSVPKGLSVEFIRQPAGTIIADHTPEFAWEVPTSARRQTAYQILVASSRDLIAENEGDIWDTGKVSDKQSINVEFKEKSLESGTYFWKVKIWDEQDQETPFSDFQRFEIGAKEDVITSANYFQVDSIKPAVFRKVDHDSYFIDFGKAAFSTLAFHYKSEIRDTLIVHIGEQLIDNQINRNPQKTIRYQQVKVPVSPSVSSYTLQIVPDQRNTKPQAVQLPDSFPVLMPFRYVEVKGAQGKLRAENFTQLFHHGYWEDDASHFTSSDSILNKVWDLCKYSIKATTFAGLYVDGDRERIPYEADAYLNQLSHYTTDQEYAMARLTMEYFMENPTWPTEWQLHVALMFHADYMYTGNTELIAKYYEELKHKTLMELRGEDGLISSENATPDFMKKLGFKNPKDRLKDIVDWPPAQKDTGWKLATEEGERDGFVFKPINTVVNCFYYRNLEIITEFARILNKPEEATELHQLALKVRQSINDKLLDEKAGVYVDGVGTDHASLHSNMLALAFSIVPEAQVSSVAAFIKSRGMACSVYGSQYLMEALYKANEADYAFQLMTATHDRSWHNMINIGSTITLEAWDMKYKPNSDWNHAWGATPANIIPRYLWGIQPETPGYATVAIRPQMGNLNSSSIKVPTIRGAIKAQYTRHPDDTERYLIEMPSNMSGAFYIDGELYSRVVLNGEEVDSDLNTIPLQPGVNDLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY56</accession>
    <name>A0A654DY56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="58" mass="6606" checksum="2D57AFE1E64877B9" modified="2020-04-22" version="1">MPKKAFERDLSTSKSLQYESYNNQGIRIFIIKREYMLLPDHVCPPTVCIGFSKLGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY96</accession>
    <name>A0A654DY96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024924021" evidence="1">
        <location>
            <begin position="29"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="522"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="591" mass="64680" checksum="E538486CC82EDEF9" modified="2020-04-22" version="1">MHITTKLKLVKKSFLVLMISFITIGQGAAQCFGTGNETDYGAGSWIGYIYEGANNYTTNYRGRVSATENFDTDFCGGPACTITTNTCTLTAENFSARFRMTQTYAEGIYGITIGGDDGVRLSIDGGATYVLQDFGYHAYQTVYTEVRLSGTYNLVFDYFEGGGDNRASIQITYIGTETGGQIGSDQDICVSGTGDPDAFTSNIAALYASGATPNYQWEVSPDGGSWSDVAGATAETYDIPAGYTGLNYYRRSAESGGVTVYSNTLTVQLTSRSGDDTAVGSGSWIGHVYDGVNNFGNNYKGDIYESEIFDESFGGDNVTSSTSGCDYQTETFTVRFEMLQTFEHGLYDFQIGGDDGVRLSVDGGSTWVIDDYSNHGYRTADAFNVEMNGSHHLVLDYYEAGGGNRVTFSYTQQTLLPVTYLFLKAENEGFSNVIRWATATEIDNDFFEVQKTADGESWEVIGEVSGHGTCKEVTNYEFTDSNVSPGVSVYYRLKQVDFDGQEEYSSLVRVGLAYTEISSLSIYPNPAVDQVNIHWPGFILKEVKIFNLAGVLVRSSNEMQIGLDGLEPGYYLIRVTDPEHEETSGRLIIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB0</accession>
    <name>A0A654DYB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="593" mass="65264" checksum="C17DFFFF10908EB5" modified="2020-04-22" version="1">MALSTLDWSFVIGFFIISLGIGIWTAKWGNKDASDYFTAGGKMPWWLLGVSMVATTFSTDTPNLVTDIVRQNGVSGNWAWWAFLLTGMLTVFIYARLWKKSGVVTDVEFYELRYSGKIARFLRGFRAIYLGLLFNVMIMATVSLAAIKIGGVLLGLSPLQTVVIAGTVTVIYSSLGGLKGVLITDFVQFFLSIGGAIIAAVVSLQHPKVGGLSNLLKHENVVDKLDLFPSFSNPEIFITLLLIPLLVQWWSVWYPGAEPGGGGYIAQRMFAAKNEDHSIKAVLFFNAAHYALRPWPWIIVALCSLVVFPDLESFRTAFPNAGSIINHDMGYPAMLTFIPSGLLGLVVTSLIAAYMSTISTHLNWGASYIVNDFYKRFAKPDATQKEMLNVGRIITVLLMVLTMIFALLLDNALGAFQILLQIGAGTGLIFILRWFWWRINAASEMAAMIISFLVAIYFGVFHKMMGFEPLASWMELVIGVGITTVGWIIVTYTSQPTSMEVMISFINKVSPGGPGWTKIINKAKADGLQLSEPSGPWKVPIGILCMIAGTIGIYAFLMGTGLFIYGRYLNAIILMGVTIVSIMVLKRFWSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC2</accession>
    <name>A0A654DYC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024931097" evidence="2">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="58" mass="6151" checksum="E6AC1D82579835DB" modified="2020-04-22" version="1">MNNSRNFLALVLLAMGMTFGACSQDDTMDELIDNTEINSPSPTGNETDGEEEPPTTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW8</accession>
    <name>A0A654DYW8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031965">
        <property type="entry name" value="CBM26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16738">
        <property type="entry name" value="CBM26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024989160" description="Aamy domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="36"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1150" mass="125623" checksum="3015452024BBFC5F" modified="2020-04-22" version="1">MYTLRKATLALIILMSCLSTHLSFGQVDFREETIYFLLTSRFFDGDPSNNAPNEWSSYDPDPNVRPSITDPQDVTWRGDFKGLIQKLDYIQDLGFTAIWITPIVHNRSPLDYHGYHAWDFTRVDPRLESPGATFQDLINEVHARGMKIVLDIVTNHAGRFGIKGQAEIKYNTDPNQPWGQDSNGNTLQPNPNWEYDGITPNPDDGKIWSRANIPTMPAPYNQNLQNYNWPSTQSYVDTSDPNWYHHSGNGFAQGWDDTENLYNRALAGDTPDLNTGSSVVQNYLIAAYTTFINMGVDAFRWDTMKHMSKDDVLAFKDAFHAVNPDLFIFGEVAQKRHELHNVEEINPHWYTWRGAVGASQNSDIAVLDFYAEATFHGVFESGESFANVQAAARYDHLYSDPSTLLTWLDNHDFGPNNDWNRRYGGSAENLAACMNFMFTWRGIPVVYYGTEIQFKKGEYADIHDATGIEKSIDETGRAYYGAEFANAPNHIIYQHIKKLNAMRRAIPALQKGAWRWDGNAGGNGVGYVRSHGSSEVAVGLAKDGSATFNFSGLTNGIYRDAVTGNEQNVSNGSLSFTVQSGSAGIYVLNGPGMIGGNGVGFFQAGSGSSQPVVSANPSGGVYSNPVQVTLSASSQHAPNTIYYTLDGSTPSTSSAVYSGALTISSTSTLKAMAVDNQGGQSTVLSHTYTIGAIEGITVYFQKPSGWSTANIHYWNLSPSGASSTWPGPTMTSEGNGWYRYDFTNASSANIVFNDNGGAQTADLSRSSDGWYDINGVWNDTDPRVTTNQPPVVSISPLGGTFTDGDNVSVTLSATDDSDPNPTIYYTLNGSTPTTASSVYSTALSVSDDLTIKALAVDSQGASSTIVSAAFTFEPPASGLIVHFKPNGYTSPEVYFWGATPSGQTTTWPGETMTAEADGWYSYTIGNAACSNLIFSNNGASQTADLYRCGEGWYMDGTWYDDLPGTSAGLTIHYQKPSGWGTAKMHYWNVTPSSVAGTTWPGAQMTNDGNGWWSYTIADATCASIVFNDNGGAQTGDLSRCGEGWYNNGWSGSARTSEGFPKVENAGFSLSQNYPNPFTDFTTIEMSLNKTQNVRLSVYAMDGKEVMTIVDHELTSGKHRFILNADQFEPGIYFYKIISSEGALIKRMLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ03</accession>
    <name>A0A654DZ03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator PadR-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12858" checksum="D107F1A53081BB4A" modified="2020-04-22" version="1">MKGTNLGEFEELLLLIVLILEDQAYVLKIQEEIRNQVQRDTSMGALHASLTRLEEKGFLSSEMTGATAERGGRRKRIYQLSSDGKIVLNQVRTQRESLWQQAPKFSLDTYGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ11</accession>
    <name>A0A654DZ11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025250">
        <property type="entry name" value="DUF4199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13858">
        <property type="entry name" value="DUF4199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="18881" checksum="4DABC9757CB315F4" modified="2020-04-22" version="1">MEETKNISVKSVAIKYGLISGLVGVIFFLVIDFAGLSGNQSVSWIGILFTAVIMYFAQKEFIKEGDGYMNYGEGLGLGTLMSLVSAVISSIFTYIYVSFINPQFIENIRQAQVIAMEEEGMSDAQIEQAMKISENFTGPTGLLIFGLIGGVFVGFLISLIISAITKKSRPEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ27</accession>
    <name>A0A654DZ27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="534" mass="60469" checksum="FEEA0A0EDF937D82" modified="2020-04-22" version="1">MTRMERYSASLPFMLLVLILMLSLFGCKGEPIMVDEPIPFSRLLENQKMSSQIFKVDINYAVLLPEDYNESTDEYPVVYLLHGFGDNEKAWYTSGSIKYYSDLYNDQIVPMIYVMPIGYNTYYVNRYTGSYPYMDMITTELVPTIDSLFRTKQDKTARAVMGYSMGGYGALILPALNPDIFTVGVPLSMSFRTDEQYISEPQGVFDYQWGTIFGGKGASGEARLTDYFKQHSPFHFFSSSNKDQFAGLKFLIDCGDDEETLTITNDALHALMRDNQIPHEYRVRSGGHSFDYWKKSYPEALKFISNSVQGIPHPSNPEPVTIGERITSSDFESVEISGVEINILKPVDYTTSTVDYPVVYVIHDYEEGQRESNVTEIFSLLRNGMTAGTLKNSMVVEVPVSESLESDRIAEIISYVDTQYRALTDRASRVILGNALGGLHAANLAAENSSLFGSCFLFDAQLQEEGVDPQTDIFYYLDISDDGDSYRGYHHFYVKIRETDIGYEYRVRQGAESFQSFLNGLSESFPSLRNSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA9</accession>
    <name>A0A654DZA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22825" checksum="4E39135B6A8B8283" modified="2020-04-22" version="1">MKKYFADGLLIVFSVLFALLINKLYTDYQTNQKKEFALRSIKQELEQNLAIVQTWKERHSAIRDKLSEVNEGKNDTLKQQLRQYPFFNFGVLTNGQSLINEIMINTAWETSKTTGIISEFDFKTTEKLTYVYLMQEVITDRTITNILDLYFDMETHKIENLDPVLIQFELRFGELAGQEYLLEHLYEDAISQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC7</accession>
    <name>A0A654DZC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="18934" checksum="B6572A20E9A18795" modified="2020-04-22" version="1">METLETPVLEKKKEAKQLKKIMIIQSKATIDSVYAALILANGARMEGIESELFCTFFGLEMLQPKKMDHLHVATVGNPGLHIPTMLGGLPGIESLASNMMKKEMDKLDIPPLSEFLEIYKASGGKIFACKLAMEMFHLKREDLWEGVDEVLTVGDFYGRAQESGVQIIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI9</accession>
    <name>A0A654DZI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein G (GspG)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031982">
        <property type="entry name" value="PilE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16732">
        <property type="entry name" value="ComP_DUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15425" checksum="1BF580EC15F224EE" modified="2020-04-22" version="1">MSNLNKKRLAAFTLSELLVVLVIIGILVLLALPSLMPLITRTRSIEAKQALKHVHTLQKTYYYEYSRFSDNLDQIGFEQEGLVSEEAGNANYLIEILEATPTTYVARATAQVDFDGDGVMNIWEIDQDGNMIETQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E007</accession>
    <name>A0A654E007_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase / fumarate reductase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="25147" checksum="8F2255424A5BAEDE" modified="2020-04-22" version="1">MSWFSNTFSSTIGRKFAMALSAIFLVLFLLMHLTTNMLSVISADAFNEASHFMGTNPVVQFLLQPVLIFAVVFHFVMGFVLEAKNRASRPMKYAKKDTGNATWMSQNMIYSGLVILAFLALHFIDFWIPEINYKYVAQLPEVTDRYYGEMVHKFQNPLRVGAYVISFVLLALHLLHGFQSSLQSMGINNKFTPAIKKFTQAYAIVIPIGFVLIALYHFINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E014</accession>
    <name>A0A654E014_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SCO1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024856236" evidence="2">
        <location>
            <begin position="31"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="25575" checksum="456DF13DAE7EF1A6" modified="2020-04-22" version="1">MEKKKKLTLTKVLRTNLALLSLILAGSACQPTARKEVAEIPLPFFNEATFTPVWVEAGTPDYKTIHTVAPFQFVDQQGDTVTNALTDGKVYVANFFFTLCPSVCPRMSKNLLRVQEAFEASEVLILSHTVMPWADTVERLQVYAELNDIQSDQWHLLTGDKQEIYSLARESYFADEGFGKTVTVEADFLHTEKVILVDQQRRIRGVYNGTIPLEMARMIEDIQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E083</accession>
    <name>A0A654E083_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">dnaX</name>
        <name evidence="6" type="ORF">MARINOS108_120363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="41750" checksum="7AEEB05066AD7B4A" modified="2020-04-22" version="1">MESFVVSARKYRPLGFEEVVGQGHITTTLKNAIDNDHLAQALLFCGPRGVGKTTCARILARMVNGFEAESGDAATNNFNIYELDAASNNSVDDIRNLIDQVRYPPQQGKFKVYIIDEVHMLSTQAFNAFLKTLEEPPSYAIFILATTEKHKVIPTILSRCQIYDFNRIEINDMVVQLQQIAEKEGVDAEPEALHLIAQKADGAMRDALSIFDLIVTFSSDNKVTYQNAIKNLHILDYDYYFKLADFFQAEDLSGALLLYDDILRNGFDGHNFLIGLEEHFRNLLVCKNPETLKLMEVPENLKGKYQEQANALSTSYLLTGLNLMNQVDLNYKQSKNQRLHIELCLMKLSQLNRAIKLSAENGVKKKAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B9</accession>
    <name>A0A654E0B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="29555" checksum="A67628961C54BB90" modified="2020-04-22" version="1">MQFRLEQEAFQEIFKDRPIQPVLETIEVDSNHVHYVYIDRGKPNLAVFIHGSPGSWSAFIDFFKNDSLLQTYDVLSIDRPGFGDSDYGRPEPSLQKQAYYLEQVISRFDQPNKVMVGHSLGGPVAARIAMDYPSLTQAMVLVAPSVDPAMERYEWYRTWIETRVGGWVTPTDFWVSNEEILPLRAELESMLPLWMAVQIPAVVIQGTKDMLVPKENAAFVRRMMGDSLADIRYLEGVNHFIPWSHPHKIVEALEALAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D4</accession>
    <name>A0A654E0D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjgF</name>
        <name evidence="1" type="ORF">MARINOS108_120349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.99.10" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120241">
        <property type="term" value="F:2-iminobutanoate/2-iminopropanoate deaminase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15300" checksum="51078802D47F6FC3" modified="2020-04-22" version="1">MSIYQSDKAPEPVGLYPHARRVGNLLFLSGVGPRVKGKKEIPGVTLNDQGEIVAYDIEAQCHSVFNNVKDILEASGAGWRHLVDVTVFLTNMKDDFGTFNRIYAEYFEDVQPCRTTVEVNALPTPIAIELKCIAALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L9</accession>
    <name>A0A654E0L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025007652" description="DUF1080 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="3">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="623" mass="68583" checksum="C36F253AB4AD9B3D" modified="2020-04-22" version="1">MNPTRIMLSSVMYLVLSALLFAQNSGMKPLPFEDLSAFQSQSGNWQIVGDVMMDPTVDVHAQPPLDKKKKKKSEAPPRPITSVSGTGVLLNMPDDDKKSHLVTNWEHGDIALEVEVMIPKGSNSGLYLQGRYEIQLCDSWGVKTARFSDIGGIYRNWEQNPETSYMGKAPLVNAAKAPGLWQKLEVVFKAPRFDASGNKIANARVISTTLNGVKIHDNVEIPRPTGGPLVNDEVAMGPIMIQGDHGPVAFRNFRYKLIGDLDIRMEDLNFEVHHGPFETESEVKESAVVKSGSISALTYEVAGKENEYGIVFTGKLTVPETTDYFFDMVYGGIGNLKIDGASIGDGWGGLSASTSLQAGSHSVEVVLFKAQSWVRSSLSLVVSTTNSYPVALHSFSSSPPGSNLVPPILIQPKSEVRLLRAFLDFKGDRSQRLTHTIGVGEPDRIHYIYDLNAGNLVCVWKGDFVDATPMWHDRGDGSFRPIGMLQYLFSGPSLAVLDTPGQGFPSSSTDLISKGYKLDYASQRPTFLYEYKGAEVSDQIVPDEEAKYFIREVVVSNPSPNTYLKVAEGRKIELLPNGWYAVDDKQYYINIQSGQVPSVRSKGDVQELILPVDTTPIQYSLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E113</accession>
    <name>A0A654E113_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="11056" checksum="CFF66F3A4A4DB7F1" modified="2020-04-22" version="1">MKKAWANFVKTFQPKYSVVVNMYHVVPGTPVKKHAHKHEFGKGELDEASIFFHKVVKRHSQLGFPNTEVQLIKGKKTVVQAKNYGPVELVKGLNVQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E137</accession>
    <name>A0A654E137_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="17956" checksum="31F4F5D6E3BB44C7" modified="2020-04-22" version="1">MVNILFKTSSWAFILVCVLCSCSREEFKDSTTFDAREWELDSDGLSIPALNALMEGEWSLRYTTLFVSDKSLIKNFNPGEVIWKVDVASKVIYRDSKTNGTQYQLALEPVDPQSPNGRLVPIIFMDGEKGYLSIGADRMVISFGYMDLPNYYFERYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E139</accession>
    <name>A0A654E139_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24101" checksum="4328EA67A6D7D56F" modified="2020-04-22" version="1">MKSTKVLISDFQFLTRAGLIHLIGEKEEFELLGTVEEPENLLGAVLSHHPDVLLMDYKSQDPVLLSLLKQVVNSQATNVLIITNEDNRQAIKDLLELGIKGIVTKNCSRQEILNAIESVALNTRFYCNRILDLLVEEDKRARENNCEPTELSPREYEVLNLITKGYRTADIAETLHLSVHTINSHRKNILKKLNLKSPTELIVYAMESGLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E142</accession>
    <name>A0A654E142_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="6109" checksum="AEBF7D812D46ADC4" modified="2020-04-22" version="1">MALTTSLLRNQKYLWVELKSGCNHEEFDLKKHRNESFQNFHSPLFALFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E199</accession>
    <name>A0A654E199_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="17041" checksum="27E78DB68A3FBFAB" modified="2020-04-22" version="1">MDIRENQYDTVVLVEDNPDDAELTMRSLNSLQLGNQIIWLKDGAEAINYLFGQQPDQSRRVSNRPKLILLDLKLPKVNGIEVLKRIKSDDQMKTVPVVVMTSSNESVDLRTCYELGVNSFVTKPINYQEFIEATKNIGLYWLLVNQVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A0</accession>
    <name>A0A654E1A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025029746" evidence="4">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16310" checksum="FD3413EA95E853E9" modified="2020-04-22" version="1">MKRKEFIKTCGIGCLSLMSGASLLAGCVGTRHINVPISDSFLLIPLSEFFNEKKEKYRKYIIVQNEELSYPICVYRFSENEYTAIWMRCTHQGTELQAYGDRLQCPAHGSEFSNTGALQNGPADQPLRIFPVTADLNQIKIDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B8</accession>
    <name>A0A654E1B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">lipB</name>
        <name evidence="12" type="ORF">MARINOS108_140146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD17680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="27348" checksum="F7F42404B37CA68C" modified="2020-04-22" version="1">MAIQNKKTKFIHLGLMDYQEAWDYQEAVFKRSVDQKIANRQLPESEQRSVDNYLIFCQHPHVFTLGKSGKPEHLLLDEHGLDEKEASYYKINRGGDITYHGPGQIVGYPILDLDNFFTDIHKYLRYLEEAIILTLKDYGVVGGRIPGLTGVWIDHEDEANTRKICALGVKSSRWVTMHGFAFNVHADLNYFGYIVPCGIDDKAVTSLDKELGYKPEMAEVEHRLKGHLVDLFEMELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J1</accession>
    <name>A0A654E1J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="534"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="725" mass="82380" checksum="C43B39A291FF1870" modified="2020-04-22" version="1">MGHFWYKLRLSHPWRYKAPVLLACVYMVFIKKQTSLSEMAPWLGLSLVTIVGIAGIGYLINDFSDRQSDGKAGKPNFFIDTSQLKVALSITVLTCCAIGPWYFFPMDRLSWVLFTGELVCFIIYSLPPFRLKKNIWVAPILDALYAHVLPVILATHTFLLITHAEFSFLHMAALVSWQLTLGIRLLINHLVEDRPHDLLNYHTLATQYSAHRIRRFLWYTMLIELLLFTSVLFFASNLFISISTGLVLLAFTLKQKSRYSFVENVPDSFYRKLLGGGLTVVLIFTHGSAYVLLLMIHMILFPVGQSHELRKVLSKLYQIGSVIVNYGIYYFRRFVLRQSEKQARREYYEQDLINKTNQMKSDQLGSITIANLNLNKYSETYIHEYKNQLPYGVDFLYGGYPPVFDEFGQPLIKSKSSINSKRQLQDAIVQRLNKTRSRLVLAHFGPMAVRMLPICRAAGVPMAAYFHAYDVHHKDQLEAHLAGYLDVFNHAHLLIGSSQEVIKKLNEMGAPEQKLKYLPAYVDLTRFTYVDHSSNQPNLLSVGRFADTKAPHLTILAFKQVLEEVPNARLTMIGDGELLEASISLTKALQIDHRVSFPGARSPMEIYEEMKNSRVFLQHSITTPLNHDKEGTPVAIMEAMACGLPVISTAHAGIAELISHEQNGLLIPELEIAQMAEQTIRCLKSVELSKKLGKNASESIRSNPLITDHMRIITEMINHFGLKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P8</accession>
    <name>A0A654E1P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SASA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024909105" description="SASA domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="3">
        <location>
            <begin position="48"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="33027" checksum="FEED1C732FE04299" modified="2020-04-22" version="1">MRKMNVTILILLSSLMSVPFYGCDKTEDMEQEPEIPPTEKVISLDPNFHIYLCFGQSNMEGSAKIESQDRVGKERFQMMQPMTCTNPGRTEGRWYTAIPPLSQCGVGLSPADYFGRTMTDHLPDSIRVGVISVAIGGCDIRLFDKDQYQNYVNTYPEDWFQNKIAGYGGNPYQRLIDLAKKAQKDGVIKGILLHQGETNTGNSQWPTYVKTIYENMLTDLSLDAETVPLLAGEVVHADQGGVCASMNEIIATLPETVPTAHVIPSSGCTAQSDSIHFDSQGVRELGERYALKMLSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T5</accession>
    <name>A0A654E1T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5723 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043781">
        <property type="entry name" value="DUF5723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18990">
        <property type="entry name" value="DUF5723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024904742" description="DUF5723 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5723" evidence="3">
        <location>
            <begin position="42"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="513" mass="57229" checksum="E00E5BFE5F616EEA" modified="2020-04-22" version="1">MMRRFYVTFSLVVACALASSAQSSLSFYHLGNATFQNSYYNPALVPEGKVFVGLPVLSGIHLNFNNKFNYKDVIIQGEVQKEIDLNLYLKSLQKNNMVSMTTAFNLFHLGITTRGGSTLALYANERIEMDFLYPKSLMEFLIKGNSGSKGETVKIGKTRLSTTYFREFGLGYSTNISSDLSVGVRAKYLQGFLNGSTPGGFTADLTTNKEDYSISLDMRDATFRTSGMDIFQGNTGNLGTHLISNNNRGAAIDLGFNLNMGPDYTISGSIADIGFISWKEDIKNYTLADTTMTYSGIDLKDPGDLVQTIEDSLINKFKNRNSETDDPYTTIISPKAYLSWTYHAHNGGDVIATGGARYIQGQMKFLLGAGYRHSFGKFFVGTVNVTKLPQQFFNMGAALALKGGPAQMYLAVDQVVNYDLTKFQAIDVRFGINFIIGQKEPESMMEANKPKVKRTKAGTQSFLGQKVDVKGQEGIYTIINKQERRKKRDYEFEGDPIPKEKNRFKQRSPKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H7</accession>
    <name>A0A654E2H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15815" checksum="860453A864A6F989" modified="2020-04-22" version="1">MRPTVWIILMFLLGSCDFRKCASRPPDVLVQLDFSQEDSSYLEFLSWELTASDGAEFPYEIRNFSDSLVSLFQVTLILVTESNEYYLDYGNEDVDTLRVLVHEETAGCDHIVIDLVEMNGEQLTMNTDSSYFYQKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R4</accession>
    <name>A0A654E2R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lspA</name>
        <name evidence="8" type="ORF">MARINOS108_20485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="23925" checksum="9F51CA2F35B3599A" modified="2020-04-22" version="1">MEKKRTPLYIYYLISLLVIAIDQVVKMAVHFNMDLGAKGQIKIFGDWFKLHYLTNPGMAFGMQIGFIDNGKLVLTLFRLAAMVAIGYYLYTLYKKETSKGLLICIAMILGGAIGNLVDSIFYGVFLDNAPYDAPTPWFYGQVVDMFYIDIWEGRIADWVPILGGDYMALWPVFNIADASIFMGITFILIFQKSFFGHETESSDQTEVKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S5</accession>
    <name>A0A654E2S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">MARINOS108_20495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="7"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="37801" checksum="9B91E5C4BA25C734" modified="2020-04-22" version="1">MVKQQILVTGGLGYIGSHSVVELHNAGYEPIIIDNLYNSTEAVLDALEEITGVRPVFRKVEMCDKDALRALFAEFPDLVGSIHFAAFLQVKESVEQPLKYYHNNLLSTTNLLELSLEFGVKNVVFSSSCTVYGNPESLPVKENESIKPAQSPYGNTKKIGEEILQDACAAHDLQAISLRYFNPIGAHPSSLIGEVQHDVPHHLVPYITETAAGKRPFVSVLGGDYDTRDGSCIRDYIHVMDIARAHVNALSRLLRKENESSYEVYNLGSGNGSSVIEMIKAFIDATGLDVPYQISDRRPGDVEAVYADISLAQEKLGWTPQFDLKEMLKSAWDWEVKQAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X0</accession>
    <name>A0A654E2X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="387" mass="43061" checksum="EC7DE7D1D5572000" modified="2020-04-22" version="1">MNIDDILFHLGESTPFGGTSASPPIYQTSNFIFPTLDHMKTALQHEDHIPFYTRGANPTVQVLQEKIAALEETEHSLIFASGSAAITAAIISQVKAGDHIVCVSNPYSWTKKLIEGILAKFSVASDFVEASDTEAILAHVRENTRLIYLESPNSWTYEMQDIEVITTFAKQQGIRTILDNSCASPLYQKPARYGVDIIVHSSTKYLSGHADVVSGVLCTSSDIYLSIFKNEYMTFGAIISPLEAWLMIRSLRSLELRMEKVSKNALEVARFLEKHPKIAQLFYTHSESFAQPELVEKYLSGNGGLMTIDLKTNNAHQVEQFCNTLKRFKLGCSWGGFESLAFPAITTMSSLNYNKPDTAINRIRLYVGLEDSGLLIDDLTNALEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E317</accession>
    <name>A0A654E317_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoB--CoM heterodisulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="149"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="29155" checksum="925E5FF614696A9B" modified="2020-04-22" version="1">MTEEINIPTMAEMVAKGESPEVLFWVGCAGSFDDRYKSVTLAFVKILNKVGVKFAVLGAEETCTGDPARRAGNEFLFQMQAMANIQVLDGYEVKKIVTACPHCFNTLKNEYPDLGGNYDVIHHSQYLQELINSGKVTLKGGGEFKGRKITYHDSCFLGRANKVYEAPRKVLEALDAELVEMKRCKTKGLCCGAGGAQMFKDAEPGKKEINIERTEEALETGATTIAVACPFCMTMMSDGVKNKERESEVKVQDLAELIAEAEGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E336</accession>
    <name>A0A654E336_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">recQ</name>
        <name evidence="12" type="ORF">MARINOS108_20662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="30"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="219"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="529"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD19298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="726" mass="83603" checksum="7052C58CEE5C7938" modified="2020-04-22" version="1">METGIDYKLKETLKRVFGYNTFRGTQEEIIQHVMDGKNTFVIMPTGAGKSLCYQLPAIVKEGTAIVISPLIALMKNQVDQMNAVGINARFLNSTLNKGEMTRVKKETLAGDVKLLYVAPESLTKESNIEFLHKANISFVAVDEAHCISEWGHDFRPEYRKIKSIIKSFGDIPIVALTATATPKVQLDIQKNLEIEEAEVFQSSFNRTNLIYEVKPKKQAKKQLIRIVKEHKGESGIVYCLSRKKVEEIAEFLKVNGVNVAPYHAGMDGNVRMKNQDAFLNEDVDVIVATIAFGMGIDKPDVRFVVHYDVPKSIEGYYQETGRAGRDGIMSKVVMFYSYNDILKLEKFNKDKPVTERENSKYLLEEMALYAESAVCRRKQLLHYFGEEYHVENCENCDNCLHQREHFDGQDYVKKVIESVSQTEERFNLDHLSKVLLGIKSEHVLSYNHHKLKIFGAGKSNDEHFWKSIIRQTLLNEFICKDIDNPGVFKLTPKGVEFMLDPYPVDLVKDHEYETEGEEEEIEKETINTTAYDKVLFDMIKNLRKKVAKQKDLPPYVIFQDPSMEEMATLYPTTMDDLIKIVGVGESKARKFGKPFLEMIEKYVEENDIITASDVLVKSSGVKSKNKIFIIQQIDLKIDLEDIAESKEMKYEQLIREIENICFGGTKLNLNYYIDQLLDDERQEDIIDYFMNAESDSIEDAMEELRDFYSEDEVRLMRIKFMSEHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E387</accession>
    <name>A0A654E387_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase / fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_110078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD15916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="26843" checksum="9C76B1D66E33C031" modified="2020-04-22" version="1">MDLKLKIWRQKNAGDKGKIVNYDIKDVSPDMSFLEMLDVLNDELIGKGDDPVAFDHDCREGICGACSLQINGKPHGPDSAITTCQLHMRKFKDGDTVYIEPFRAKAFPVIKDLIVDRSSFDRIQHAGGYISVNTSGNTQDANSIPINKEDADNAFDAATCIGCGACVAACKNASAMLFVSAKVSQFALLPQGQVERKMRAEKMVAQMDEEGFGACTNTGACAAECPKEISLTNIARLNREFLSSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E388</accession>
    <name>A0A654E388_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="152" mass="17231" checksum="00991DF847C16DDD" modified="2020-04-22" version="1">MPVILKYLTVYALSALKIIFGPTLGLAYGFSVLETTLLSLLGMMSTVYLLTYFGPEIRNLSLRLFKSKKKRKNFTPKRRRLVRIWTKYGVAGIAFFTPILLSPIGGAILANAFGGKRSEIIRWMWLFGAVWAFILTLLTRYAGWLLEDFGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F7</accession>
    <name>A0A654E3F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="15272" checksum="300282A4B4B6AACA" modified="2020-04-22" version="1">MILETTYNKRETILQINQLVGKPYTLMQRLRMGGIGSRRMGISQVSPEYTHYLKAGHYITHANIELRPEGILIHFRFKLESYAWPMPYADLQISTSPELTFTSGGKFIVFKDGMKVNGSFIERMMSHLATAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M6</accession>
    <name>A0A654E3M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygdQ</name>
        <name evidence="2" type="ORF">MARINOS108_20511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28243" checksum="4E66304CC0C1B9CD" modified="2020-04-22" version="1">MEIFLQPEAWIALLTLTFLEVVLGIDNIIFISIVTNKLPREKQGKARTLGLALALLFRIGLLLGITWIITFTEPLFSVFNTEISGRDLILLVGGLFLLFKSTLEIHHKMEGEEDHENQRAVRSFLGTIVQIILLDIIFSFDSILTAIGLTEEILLMIIAVVISIVIMMIFSKKISDFIGQHPTLEILALSFLILIGFMLMIEALHYHVPKGYIYFAVFFSLVVEMLNMKMRKKRNPVKLRKRISAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R8</accession>
    <name>A0A654E3R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rny</name>
        <name evidence="8" type="ORF">MARINOS108_20922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="519" mass="58556" checksum="36F20AB46539CAA4" modified="2020-04-22" version="1">MDILYILIALGGILLGFVIDRVILKRSITKKLKSAEDQKKLILKEAEVNAESIKKDKVLEAKEKFLKLKTEFEEEANRKKNLLITNENKLKQRESTISKQIEQNKRVEAELESAKENLQAQLEIVRKRKEEYEKLKNQQVSILEKVSNLTAEEAKAQLIQTLKDEARTDASAHIKEIMEEANMSATKEAKKIVLQTIQRTATEHAIENCVSVFNIESDDIKGKIIGREGRNIRALEAATGVEIIVDDTPEAIIISGFDPVRREIARLSLHRLVQDGRIHPARIEEIVSKTTKNIDEEIVEIGERTVIDLGIHGLHPELIKLVGRMRFRSSYGQNLLQHSREVANLCATLASELGINPKQAKRAGLLHDIGKVWPDEPEKPHAIIGMELAQKYKESPDICNAIGAHHDEIEMTTMISPIVQACDAISGSRPGARREIMEQYLKRLKELEEVALSFEGVNKCYAIQAGRELRVLVDAENVTDQRAGELSFNISQKIEKDMQYPGQIKVTVIRETRAVAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S0</accession>
    <name>A0A654E3S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kazal-type serine protease inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="SSF100895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="7363" checksum="8F3D25936C5B71CB" modified="2020-04-22" version="1">MKLAFFFLALAAGCTRTSEVCIDEDKINEQAICTMDYNPVCGCDGQTYSNACHAESRGLISYDPGACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V8</accession>
    <name>A0A654E3V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="PTHR28106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025036431" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="20466" checksum="B49C7EE82402C769" modified="2020-04-22" version="1">MKKLILAFIFCSPALLFAQKGTIFPNLAGENLMHGEVNLPEDVKGKHTLIGLAFSKKSEKFLNSWFTPVYDQLIKEPEAGLFAFSYDVNVYFVPMLTGAKRPAYQQVMKNVEKDVDPRLHPNVLFYQGTLKEYKDALNITDKDLPYFYLLDKEGKIIYATSGLYSRAKLQKIVDELPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W6</accession>
    <name>A0A654E3W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="514" mass="61824" checksum="8B18C42F32F4FCEB" modified="2020-04-22" version="1">MPKERSDHLFTLIRSMRKNEKRYFKVRNKGQNQDDAKYLMLFDALDKMEAFDEDLIIRQNEWINPRQFSNLKAHLYKKILQSLKEYTASSNEDINIREQIDYIQILFDRSLYQQSMQLLQKAKKVIKKSDNLELQLEVLKWEKNLLPYSIGKGNQKRVSQVVAESNDINEKITRVNQLTNLSVELSAIYLKTGYIRNKEDHDRISNIFSSQIPEWNQSEFSFRERLLWYDIQLSYYSFIQDFDEVFEYAKKWVSLFDYPPTSAYYFEMYLKGLNHLLNAQARLQKHEEFQETHRRLRELANHRLVKLNENLQIRLFKYSYAHQFNGYFMVGDFQRGVNLLQRIEKRLEGYIGMLDKHSELVLFYKIACLYFGNANYRKALKWLNRIINSEDEDIRQDVHSFARIVNLITHYELGNRDVIDYYIRSTYRFLLKKHDLHSFQQYILAFLKSLSRETTQKELIQGFVELRNQLLNLAQSKYDKRAFVYFDIISWLESKIENRPVGEIIKEKAMGQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y5</accession>
    <name>A0A654E3Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1318" mass="142945" checksum="A541E8119ECD57C9" modified="2020-04-22" version="1">MKIKNKSAISAVGALLILLCTVYWMKQGDQEISHDDTIVKEEVSRFERKHLMLPEERFKIRQQLTYREGGVNYQPGYLQKELVKSLATANVSKSRSVPVNIVERGPSNVPGRARGLIVLPQDDTHMTWLVGSSGGGVWKTTDGGASWIDKSPNFPTLAVTSLAYCESQPDVIYAGTGEYIASAYTNINGDGIFKSLDAGETWTQLASTAGNELWQSVTRVIVDPNNPDVVLASTAPNFWGSYTSNIMKSTDGGLSWNSVFNAQAGAIEQIVASPNDFNILYAGQSGVGVLGSLDAGDTWSLISDGMSPSSRVELAVSPVDPTRLYASVVGGLDASQEADIYYSNDSGNNWTLITDPSNTVDVLGGQGWYDNTILAHPFNLNEFYVGGIGIYKYTVDVAAGVGESDPTFLGTETGGTEAFMARVNFTAELDGGTLALGSAPADEFTSVEIRFGPGRSQKAHRFLVPSGRGSGVGDAEYTYQDYVDVPFEVWDVDATPERQLMVAFRDQQRDGIFNLIYNNTEGGENDANNTHSREYLYINSRTYSETPSDAIATTGGHVDDDLFFIWPYLVAGATWDPDNLPESAFRINWGTVVSGQYDVVSAADPYGRVDGKNSNVHPDHHNLVAVIHDAEAKEWQIVNVNDGASYASNVSANPGVSLNSWHFAGSMMNTTQFYGADKAPGVDRYVAGAQDNGSWFSPSGEDASKTTEYEEAWGGDGFDAVWHPTDINKLIVTSQNLGIGRSIDGGNSFLNATVGLGADPALPFIGQFSNAPQRPDVVFTLAGNGVYKSDDFAGSWELIDMTGYSDWATSSLMSIEISDATPDVMWAGASISNSGSLFLSTDKGESFAPVPDNGINTGLITGIATNYHDYKTVYVLFSYAKSAKVVRSTDLGETWEDISGFSAGSTSTGFPDVAVYDLQVMPHDPNTIWVGSEIGIIESTDNGASWHLLDSNMPRASVWEIDLKEDQLVIASHSRGIWSYTLPEVPLITYYPEITDVSAGLSNEVGVLVNFISDFDSAQLYINGDYASSVVSPDLGENLFTASTSETELEIVVRGFKGSAPYTSDAFEFTTYSFAATQSSYVDRFDTDDDHFTGSMEIKKVTGFPSQAIHSAHNYEANSNKVFNLLIPIEVKSSDATFSYKDVAIVEPGADYVTLEGSTDGISWVTIAKYDASANDKWTAAFESKLSGREDYFVDHEYNLLDHFNAGDVVVFRFRLQSDAQVNSWGWAIDDVAIQGEILAADQILSSLKVFPNPTTDFLAIESQVPLAKVELFGLDGSVKRVSFNNNQLDMRGLRTGIYLLKIVSENGSVQTLRVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E462</accession>
    <name>A0A654E462_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="23377" checksum="CC9B07E5875159F2" modified="2020-04-22" version="1">MKKLYIIRHGETEYNKLGMVQGSGIDAPLNETGELQAEAFYQAYHHIPFQKIYTSNLGRTQQTVQKFIDQGIPYEALADMREISWGSQEGVAFTPESSTEYQRICESWTQGNLTAKIQNGENPLEVAERQKRAMDYILSQPNENPVLICIHGRAIRIMMCWMLNYPLSHMDHFEHTNTGLYLVNWTGSQFSIELFNETSHLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E466</accession>
    <name>A0A654E466_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">hemE</name>
        <name evidence="13" type="ORF">MARINOS108_20720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD19402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="339" mass="37429" checksum="1BAE11E43B1EE547" modified="2020-04-22" version="1">MLKNDLISRAARGEKTERTPVWVMRQAGRILPEYRAVRNGLSGFKELVETPELAAEVTIQPVDILGVDAAIIFSDILVIPEAMGLPYEMVEKTGPIFRKTVATTEDLTSLKVAKAEDLSYTLEAIKITKRELSGRVPIIGFAGAPWTIFAYMVEGSGSKTFSKPRKMLYTDPELAHRLLDMITQSTIAYLKGQIAAGADMVQIFDSWAGVLPPEQYQKFSLAYIEQIAAAITEVPVTVFAKGAFFAIADMANISCNTVGLDWNMDVQEARKLLPGKTLQGNMDPCALYGTFDQVKSETIKMLKAFEGHPHIANLGHGVYPDTDPDKVRCFIDTVKEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E1</accession>
    <name>A0A654E4E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="10353" checksum="14701D177162A158" modified="2020-04-22" version="1">MTKNRFLGLSFPERAKWLYFNGQLITSIRYYRHKINLYLLDRVYVEVFYNNSEDRVDRIEPLDVRSKRMNFYADQIKLPRDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G1</accession>
    <name>A0A654E4G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase HipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HipA_C" evidence="2">
        <location>
            <begin position="51"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="35139" checksum="1083D9DD40B1ABC5" modified="2020-04-22" version="1">MTCLYCYRDSEGDFHTNCSKKIFGLPKPPNVPYTEEDLLNLAEQMIRGKSTITGVQPKLSLHIEKPDNESAKLTIVGLWGQFILKPPSSKWNELPQIEDLTMHLAEISNIRTAEHSLVRLGSGELAYITKRMDRRDGNKQHMEDMCQLLGRLTEDKYKSSHEQIAKEIKRSSINPGLDLVRFYELTLFSFLTGNADMHLKNFSLLKNNYGHYELAPAYDLVASALVVEGDDEELALTLCGKKKRLKKSDFFSAMTTSGIPDKAAENILNKYSKLSNRWLAFVNQSFLSKEMMEQYSQLITKKRDQLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G3</accession>
    <name>A0A654E4G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="382" mass="41465" checksum="0120B64E2E0D1E02" modified="2020-04-22" version="1">MFKKYSKNFWLLSFSSYLFFSSFTMIIPELPAYLTSMGGKEYIGLIIALFTLTAGISRPFSGKLTDHWGRIPVMVVGATVSGLAALLYPVVATVSGFLLIRLFHGFSTGFKPTGTSAYIADIVPADKRGEALGISSFFGSVGMASGPAIGSWFFLQYGIDGLFYLSSVFAFASVAILIGMKETLKTKQAFHPKMLKISRSDIFEPSVFTPSTVMILTTLAFGTVVTLAPDFSDFLGIKNRGLFFVVFTSSSLLVRIIGGQLSDRFGRKVVLKVSTLLIFTSMIVLGFSITPFQFFAGAFIFGIGYGLNSPTLFAWTIDLSPEASRGKGVATLFIFLEIGIGVGALISGTAYQGVNERFPLIFGAAGFFSLIAFLYLQFFNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K3</accession>
    <name>A0A654E4K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Quinol:cytochrome c oxidoreductase monoheme cytochrome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024821620" evidence="5">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="22995" checksum="22937DC7035089C6" modified="2020-04-22" version="1">MKMLKHTYQILVAGVVTAMLGACAAGVDDTGLEYAPQMYHSTPYEPLSQITDESKGSWLDSNPEDEHGEFYNSNPYNPFKMTMREPVANTIKRGEYIASNGIAADDYATAEEVLTNPFADSKEALKEGKALYLRFCEHCHGEKGAGDGLVGEVYKGVTAYNSATVKDKKAGHIFWVITNGKGRMGAHASQISVDDRWKIATYVQTLQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q1</accession>
    <name>A0A654E4Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication-associated recombination protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rarA</name>
        <name evidence="3" type="ORF">MARINOS108_50081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="55"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="48712" checksum="AE840C7D14965A5A" modified="2020-04-22" version="1">MPIGHRAIYLCGMSIFQDNSPLAERMRPSNLDQLIGQEHLVGEKGILKRSIASGRVPSMILWGPPGTGKTTLANIIANQVKMPFHTLSAISAGVKDIREVIGNIRGGSKAILFIDEIHRFNKGQQDALLGAVEKGAITLIGATTENPSFEVNAALLSRCQVYTLNHLEKGHLKTIIEKALVEDHELKKMQVDLKETEALFNLSGGDARKLLNILELVIKSDENTKEIVITDEKVINAVQRKTVLYDKSGEMHYDIISAFIKSIRGSDPNAAVYYLARMIEGGEDVKFIARRLLILASEDIGNANPTALVMANATFQSVNVIGYPESRIILSQCVTYLACSPKSNASYEAINEAQRVVARTGDLQVPMAIRNAPTKLMKDQGYGEGYKYAHAYEHNFTEMEFLPEEIRATRFYDPGKNPREDELRKFLKNRWKEKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U4</accession>
    <name>A0A654E4U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="49393" checksum="8F6346E3EF1D291D" modified="2020-04-22" version="1">MDSRVDMRYSTLFFILFFGVHMICRSQDLAFPGAEGFGRYASGGRGGQVLVVTNLNDSGPGSLREALREDYPRIVLFAVSGNIELESPLDINHGNVTIAGQSAPGDGITLKNYPLKVKGDNVIIRYIRSRLGDERNVQDDGMSAMDNRNLMIDHCSFSWSTDESASIYDNELVTVQYCIISESLNNSVHQKGTHGYGGIWGGKKASFHHNLLAHHNSRNPRFQGARYHKKPEHEIADFRNNVIYNWKSNNSYGGEEGNYNLINNTYKPGPATESKVDKILDPYEPYGHFYLEGNELIGNPHVSDNNWAGVNGGDAVVSQIRLENPLEVASVTTQSAKASFEWVLKSAGASYRRDAVDQRIVEEVREGKATFGNNGIIDSQTQVGGWPVLQSEKAPKDTDRDGMPDKWEKRRHLNMKKDDSAEIGLMEHYTNIEVYLNELVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U6</accession>
    <name>A0A654E4U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_60019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="581" mass="64890" checksum="44F4D69997BE1F9C" modified="2020-04-22" version="1">MILGTIFIIVSNLFGIVPAVVVRYSFDLLQRSYDIFKAFSGFELQSETYDVFASSIFILGLLILISALLKGVFMFFMRQTIIVMSRHIEYDLKNEIYEHYQSLPLSFYRRNNTGDLMARISEDVSKVRMYVGPAIMYGISLFTLFAMVIPFMFSINPRLTLYSLIPLPLLSLSIYFVNNIIDKRSEEIQKSLSDLSTYVQEAFSGIRVVKAFVRERDMDQEFDKASENYKDKSLKLANVQALFFPLIMGLIGLSVILTVYIGSVEVFNGSISTGVIAEFIIYVNMLTWPVASLGWITSIIQRAAASQRRINEFLDTKSEIVSTENLSREIEGHIRFEDVSFNYPDSGITALKHVSFEISPGQSLAIIGTTGSGKSTIANLICRMYDTTEGTLTIDGEDIRKYSLDSVRSQIGYVPQDVFLFSDTIAENIAFGADSMETADVHKAAADADLLENIDRFPNGFDTRVGERGITLSGGQKQRVSIARAIAREPKILILDDALSAVDTKTENAILNAMARIMKGRTSVIISHRVSSAKLADKVIMLDDGVVLESGTHEELLARGGAYRELHDKQLVSESEEKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y9</accession>
    <name>A0A654E4Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024521">
        <property type="entry name" value="DUF3641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026351">
        <property type="entry name" value="rSAM_SeCys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728">
        <property type="entry name" value="PTHR43728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12345">
        <property type="entry name" value="DUF3641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04167">
        <property type="entry name" value="rSAM_SeCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="48"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="39144" checksum="252A4E5DFB9B106F" modified="2020-04-22" version="1">MNLATLKRQNHNLANTNRQIEILDDHEAIGIPSFQEKLQNIDLFPLKSTGIEIFQINVGKMCNQVCKHCHVDAGPDRQEIMTKETMQQILDALRGTEVKTVDLTGGAPEMNPDFRWFVEEITAMGKSVIVRCNLTIILANPKYHDLPDFFKKHKVNVVSSLPYFAAKRTNAQRGEGVFEKSIKALQMLNEVGYGMPGSNLKLVLVYNPSGAFLPGDQAELEQQFKQKLLELYEVQFNELFAITNLPISRFLDYLITSENYEDYMHELVNAFNPAAASGVMCRNTLSISWDGYLYDCDFNQMLDLKLEDVPVHISDFDLISTNERTIRISQHCFGCTAGAGSSCGGVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E529</accession>
    <name>A0A654E529_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl oligopeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="170"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="33989" checksum="7A368597DE446ADA" modified="2020-04-22" version="1">MKNLCIVLAIALLASCQPKSTTPDQLLRVPYQSTAMKVERDFFVYLPAGYEESERDFPVLLFLHGNGERGDGKAELDYVKAHGPLYEVWAQKKELPFILIVPQLPMYGMDSLADYIRNRTPDQIPQRLETGVPPRPGKFPTPEIMSGDPQDTSFNVGVEGLPVGWPMVEDDLLWMIDHVLTNYKADASRLYLSGLSYGGFGSWYMASKHPDLFAAVAPVVGWGHPGLMEPIAKNQIPVWAFAGGRDPVVRAKYFYAGINKLEELGLKELRFTVHEDMGHDAWTRIYAGDDLYNWFLEFEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E587</accession>
    <name>A0A654E587_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nuoD</name>
        <name evidence="4" type="ORF">MARINOS108_50039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="3">
        <location>
            <begin position="116"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="374" mass="42975" checksum="BBE82A023846B986" modified="2020-04-22" version="1">MLINLGPQHPSTHGVLRLEVITDGEMVKDVVPHPGYLHRCFEKHAESVPFNQVIPYVDRLDYVAAMNSEHAYAMGIERMLGISERIPKRVEYIRVLVAELNRLASHFVAIGTYGMDIGAFTPFLWMMRDREHILRLLEWASGARMLYNYVWIGGLFYDLPVGFEERCVSFSKYLKPKLRDLEKLLISNKIFIDRTAHVGTLPLDLAINYGVTGPMLRGSGLKFDLRRVDGYSVYPELDFEIPIGEGHVGEVGDCWDRNWVRFRECEESLKIIDQCLTQLTSDHKRTREFDPREMVPKKIRPKAQDFYIRAENPKGELGFFFRTDGRSDQALRCKARSCCFTNLSVLPEISRGYMLADLIAIVGSLDFVMGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5M4</accession>
    <name>A0A654E5M4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ORF">MARINOS108_60022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="149"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="249" mass="28475" checksum="5C20993C70D5DA96" modified="2020-04-22" version="1">MRYFLDISYRGTAFHGWQIQPNAHTVQEEINRALSIILQQDISCLGSGRTDTGVHALQQIAHFDAELSDTLDQLQYRLNGLLPAEVSINSIRPVKPEAHARFDAVRRTYHYHLHRQKDPFKTGVSYFFSRSLEAAPIQEAIGLMKNWKNFQAFSKVHTDVNHFDCDIYEINWQETNEGYVFSVSANRFLRGMIRAMVGTLLEVGQGRLNQTDLKNILESGERSRAGRAVPAEGLFLTEVKYPESIYLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5P7</accession>
    <name>A0A654E5P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23595" checksum="01F12ABB61062752" modified="2020-04-22" version="1">MPSYFTGLLFGLIFIFSFGPGFFALLQTSVQKGFKKAIFLALGISLSDVLYVALAIMGLASLLEKPTARMWMAIVGTVVLIAYGLYSWFKKPKIYQEKQEADTELSYLKYMLKGFVLNGFNPFIVIFWLGIIGLVAVNYDYSSGEQIYFFVGVLTTILVSDITKAFIAYRLRAMVTPKKILILNRSVGVILILFGIQMIYFLFNNFLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E694</accession>
    <name>A0A654E694_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="293" mass="32621" checksum="E79FEA2EC9285DF9" modified="2020-04-22" version="1">MKGKKIVRLLVVLVVLVGVFLVVKYTGNTGRSKTFRSSLVEIDTAKVSKLEILSPGDTTVLTRESGEWKVNQLKKADKNTVKALMNNLKQIKPSRLASRTEDSWKDFQVDDAGTRVIAYEGSDKVLDIILGRFNVEGQRSFYSYVRLNEEADVYVAKDFMKMSVGTGSADYRNDDVVRLVKDSVSSIAFNYSDSAFTLDKVDGKWQLGEMAADSASVVKYLQSLTFVNSKNFAERSGAPVLYDLVIGLNGGNDIQVTAYGNDQFSSSYNEDEYWQDSAVTDKIFKGKSYFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6F8</accession>
    <name>A0A654E6F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">undec1A</name>
        <name evidence="3" type="synonym">coaBC</name>
        <name evidence="7" type="ORF">MARINOS108_90150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="187"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="400" mass="43710" checksum="6DB44AF8C4D2064D" modified="2020-04-22" version="1">MLEGKKVLLAVCGSIAAYKAAFFVRLLVKSGAEVKVIMTESAKDFITPLTLATLSKNPVLSSFYQNENGEWHNHVELGLWADLMIVAPVSANTLSKLANGAADNLLTAVYLSARCPVMVCPAMDLDMYQHPATRRNLKTLADYGNIIVDAESGELASGLSGEGRMAEPEHILEKVKTFFQQTQSFVGKKVMMTSGPTHESIDPVRFIGNHSTGKMGKAIALELANRGAEVEFISGPAAHAPHHPLIRVTKVTSAEEMFEAAKAYFETSDIGIFTAAVADYKPETMATSKLKKKEQALQITLVPNPDIASQLGAMKKKHQFTVGFALETDEEQVNARKKLESKNLDVIVLNSLNHEGAGFAHDTNKVSIFDRHNKEQHFELKSKVEVAKDLVDFIEQSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6T4</accession>
    <name>A0A654E6T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ada_Zn_binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9540" checksum="37FEAF059AA9ECF8" modified="2020-04-22" version="1">MIPELHTSITDRQLKLMIRNGKIGLAGNRKLKIYGKLSCVSGKRMKRENRIFFEHEPEALTLGYRPCGHCMSAAFKKWKHGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7B7</accession>
    <name>A0A654E7B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="141"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="389" mass="43689" checksum="53F7FF15155B74FA" modified="2020-04-22" version="1">MNSDDVIHHCSLFFMPKTKRVLLKFSAFLLGAILLFFLSIMAFIHFAPQFGAKPSGEHLEKIARSPNYDSKQFINLIETKMDNSLSNMWGMIKEYASAKNTAPSATIETQFGKENKSTSDTTVRVTWFGHSAILLEIGGKRIFLDPMLGPAASPVPFFAKRFKNKPAFDLKTLGKLDAVIFSHDHYDHLDYPTIKAIQDQVGHFYTPLGLGSHLQAWGVPKNKITELDWWQSAQLGNLTFVATPARHFSGRGTVDANKTLWASWVIQGSGNNIYFSGDSGYGPHFKEIGEKYGPFDFAMMECGQYNERWKAIHMMPEQTIQASLDLGGKAVMPIHWGAFTLAPHEWYEPAERVLKAAQEAGVNLITPRIGDSFILGETLPQTTWWHEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7U7</accession>
    <name>A0A654E7U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Y4mF family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017507">
        <property type="entry name" value="Tscrpt_reg_HipB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03070">
        <property type="entry name" value="couple_hipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="8310" checksum="8ACE3323A28803E8" modified="2020-04-22" version="1">MKQTPLAQFIKEKRKQARMKQEDLSFAAGVGLRFVRELEQGKPTLRMDKINQVLNLFGYELGPIEASRDEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7V9</accession>
    <name>A0A654E7V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="44434" checksum="3BB2B5315B42F30F" modified="2020-04-22" version="1">MKSFGEIYTSISSNFEPQNRTLSEIGIILTKAYSVYKHPKFERFSPFTPGNQTEELNRTTVERLTWEIQQIKTNDNGKYIVASEGIERAIADIQTLNVYSLNPNDAEHFESIFNSAKMDANLKYLIEISRQGLLFTHQKNIQEHLKELPDKEAKLNYLNNTLFSLKQNVKLWDKKLYETLTAFLDVEVQKWEKFTESKESQVEFKSADQLHDFIVKLIKERLSHNIRYLEGYRVFWRDEPCQTQPKKENEIQPYIKSILKPYCDELGIRIVRENSVANGKIDITFSYLNFTICLEIKKAHHQDILTAINTQLTEYMIGEETQYGIYLILWYKSESGYNKPTSHVNIEELIGHIEIERDDYKYQIIGLDCTKPISPSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8G2</accession>
    <name>A0A654E8G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inhibitor of KinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="26916" checksum="9EBA1557C0C10B31" modified="2020-04-22" version="1">MSPKIVFRTLGPETLLMEWPEVINKETLTSVTDYFKAISNELAEQIITCYPAYCSIAIHFDSDRISAAKLQESIRQLDLKEGQKSERPCWELPVCYAEVYGVDLPRMAEVKKIDPEEIILLHTQTSHSVHFFGFLPGFMYLGGLPTALHHPRKQTPTRKIQQGSVAIGGSQTGIYPSSSPGGWHVIGNCPVPMFDPSKNPPCFIRMGDEVKFNAVEVDEYLSIKELIAQGKYNPKTTALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8N9</accession>
    <name>A0A654E8N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LptD_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045659">
        <property type="entry name" value="LptD_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19838">
        <property type="entry name" value="LptD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024868588" description="LptD_2 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="LptD_2" evidence="3">
        <location>
            <begin position="232"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="928" mass="104738" checksum="1D90537725A9D830" modified="2020-04-22" version="1">MRRIALVTIFLSIVIRLQAQVDSTSTESTDKGLVGSNPELEFTGSDFIQANDSSRLALMPADSLIAPPDSLAAPSKKASKKNDIETTINYTAKDSMIFEIEDRRLFLYGNTHIDYGSITLESDQTTIDWNERNIKSKYTLDTLGRKRGKPVFSQGGSVYETDDILYNFKTKRAIIKGVITEQDGAIMHGEDVKKNEENELFIKGAKYTTCNLSDPHFFIKSEKIKVIPGNKVVSGPFNLKFREVPTPLWFPFGMFPQPRQKASGIVFPSYGEETRRGFFLRGGGYYFGFSEYFDLKLTGDVYSKGGYALDATTNYKVRYKFNGSMNFAYNKNVTETETVPNETNDFWIRWSHRPETRGNSSFSASVNGGTRGFNTNNNVAIYNPQQSISSEFQSSLSYSQKFQRIPFNMSSTFRQRQNIQSGIYNMSLPDFALNMNRMYPFKNVVKSSNSPIAKISFSHNFVAKNEISNSPVSPTALGFTPINGNVTEDEDPIKLNIENLGDIYDRSKIGGKHTIPVSTSFNLLKYFTVSPSFNYQEVWYTRELDYTFVPEQNGVRVDTVEGFSRAGSWSSGASVNTRMYGMYYVRGIAGIEAIRHVMTPSLSFSYNPDFGDEKYGVYETVQMDTLGRTKRLSKYQNFAYGSPSGNESRTVSFGLTNNLEMKVRARKDSVNEFKKVKIFENLSVNSGYNFAADSFRLSNINWNARTSFFNQKVNLTLSGAYDPYLYIEDGTSSGQKIDRYAWNNGEGIGTLRTLSSQVSFSLKPKGSKESNDNPNSNPNDRSAFADDGAAIDRSPFGTEDEKEYIKQNPEAYVDFNVPWSLRVAYNVNRTKNGLDDALISSHGVQFSGTLGLTDKTQITFNSGYDIKNKDFTQTNIGVARDLHCWTLNFSWVPFGRYQSFSLIIRPKSALLQDLKIEKRRSFQDFFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA81</accession>
    <name>A0A654EA81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15574" checksum="789484429C6C25F8" modified="2020-04-22" version="1">MINLFKPKLLTSVKVNFSSTDEQIFQSITGIRHYSIVNPTSGNEYVPHVRDKSFLEETFKIRRFALPVQSKPLNIRSTSFDTLWWSSEYINTASVKSHHIVVGNLSRTATDLDNTHMMCLKKLIINKLDSTILFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBD0</accession>
    <name>A0A654EBD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound lytic murein transglycosylase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025009784" evidence="2">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="449" mass="51475" checksum="F337C1D36AA9463B" modified="2020-04-22" version="1">MRIFFLGLFVFSVVVATAQSDFGYDYIPDASYEEIADRISCIESEVSLEYNEKVKSFIDYFTVRDRPYTQEVLNKTALFFPIFEETLAKYNLPDELKFLSIVESGLRPNAISRANAVGLWQFMSSTGKMYGLNNDWYLDDRMDPYASTDAAARHLRDLYSMFDDWELALAAYNCGPGNVRKAIRRSGYKKKFWEIYPYLPRETRSYVPQFVAICYTFNYAPEHNLFPESHQIFPRFDTIMISQYFHLETFAKQVNVCLDDLLNLNPNIKRGAIPEGTKNFALRIPADLKDTVVSNRAFFYDAAGKVGKEQLEYLARNTPGSTYGREKQVYRVRSGDVLGTIANRYGVRVTDIKSWNNLNSNMIRVGQYLQIWVLPTYNSSTKDLYASSARTENKAVVLEGKKVHYVQNGDTLWEIANTYAGLSIEKIKALNNLTSNTIKPGQQLIISSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECC0</accession>
    <name>A0A654ECC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multidrug efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acrB</name>
        <name evidence="6" type="ORF">MARINOS108_20337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="5">
        <location>
            <begin position="371"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1046" mass="113740" checksum="A4BE5400A981FD03" modified="2020-04-22" version="1">MIADVFIKRPVTAIVISVVIVLVGLIAMTTLPVSQYPDITPPTVSISGNYIGADAETVEQTTTTAIETQVNGTPGMTYMSSNSTASGASSVTVTFDVGTDIDIATLDVQNRVSVAEPSLPEIVKRLGLTVRKRNPSIFMALALYSPEGTHDATYLGNYANIYLKDAMLRVKGVGDIVSVGDDFGMRIWLNPDKLASLKITPAEVNAALAEQNLQMSAGTIGGTPQPKTQAFEYNVISNSRINTVEDFENIVVRTNPQTGSMVYLSDIARVELAKFNYGNHPFVMGHEAAFMLLYLEPGANALETGKGVEKALTELRASFPKDVDFLIPLETTSVVEVSISEVTHTLLEALALVVFVVFLFLQNWRATLIPILAIPVSLIGTFIFFVPFGFTINTLTLFAFVLAIGIVVDDAIVVVEAIQHNIDAYKMSAKEATKKAMKEISGPVIAIALILAAVFVPVGFVPGIVGKLYQQFAITIAISVVISAFVALSLTPALSMMLLKPSNTGEKRNLLDRFFMAFNRWFDRVSGSYTKSVSTWIRKTPYVLVMMICLFVGLTYMFQTKPTGFVPTEDEKRMYVAYEMPEGTSTTRNIELHLELQRRVMSIPAVDVVGGLAGLNILTFSNKSNSGTLFVNLKHWDDRDPETEGVPQIMNQIRQMTADIKEARILVIAPPAIPGLGRSSGFTFELLQTTSGDDIKAFEGVMNQFIGAANQRPEIGMAYSFFSARTPSYQVDLDKEKAKKLGVSVSEAYSTISTLLASSYVNDFNIYGRNFRVVTQADTVYRSDISDIGRYHVRNSVGDMVPLSALITTKMIETPAVISHYNIYRSAEILGAASDGYSSGQAIEALREVAEQVLPAGYSYEFSGMSREEIKAGSSTGIIFAISILFVFLFLTALYESWSVPFSVLFAVPIGAFGSILTLMLLPGLTNNIYAQIGLITLIGLAAKNAILIVEFAKERVDQGMDIVESTLEAVRLRLRPIIMTSLAFILGVMPLAFSSGAGAEARKTIGWTVAGGMIAASSLAIFVVPVLYVMITKIAYRKKKEEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDA8</accession>
    <name>A0A654EDA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="20342" checksum="A7C55C5DE38D7B24" modified="2020-04-22" version="1">MTDTSEKYYPIEQVEDISMRDREDAMGAYLMMFAALAAGLPLPILNLIAAVIYYYVNKGKSRFVKFHALQSLYSQIPTTLMNAGLVFWTFRIIFNEGSFRSSDVFMEGFATVSELYWGYLWVVVAANLLYVIFSLVGATKARKGRFYYFLFFGKLAYHFAYRKEESSDAPVLNEPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFF8</accession>
    <name>A0A654EFF8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_90031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="310" mass="34867" checksum="BAF630F33323787F" modified="2020-04-22" version="1">MGLIVSSLGLSAQSYDFVVAKDGAGDFQTVQAAIDAVPHLRKNRTIIYVKSGVYKEKLILPTSKTNVSLIGESAVETILTFDDYASRKNMFGEEIGTSGSASFFIYGDGFEAKNLTFENSFGEGSQAVAVRVDGDRVKFENCRFLGNQDSLYPHGKDSRQYYKNCYIEGTVDFIFGWSTAFFEGCEIFCKRNGYITAASTEQETPFGFVFNNCKITGLAEAGTVFLGRPWRPYAQTVFMNCELGEVVHPEGWDPWRSEEKKKTAYYAEYANRGVGYQPDKRAQWAHILTDLEAEKYSLKNVMRDWNPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTE8</accession>
    <name>A0A654DTE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024999000" evidence="1">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="26536" checksum="2B2FD766AE4BC39B" modified="2020-04-22" version="1">MKHFIPSFFLTALTLVLAHTNSVAQYSSSSSVKISVGTVYDRESGRLLSEEELTQLITNGNPAFEPQMDQYGQASTFVIDTSNPYAPINMRDISRRPQVGEIVPTFIMKSLNGDLLNLEKLSGYYVLLHFQLTVKPPIFNLSRFDSFDSEVGVLKKNIPLKTITIFQGVQREIESILEPSQYQTQIVPDGRGFSMRYQIVDYPSFMLIDQQGRLIGYYKQDEWEKLKSDLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTH8</accession>
    <name>A0A654DTH8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="326"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="47365" checksum="0DCDBEFEDABE0917" modified="2020-04-22" version="1">MPLTLEEIKYQHLKGSTQILLASFDGKVLASCNTLVPIPVGYDLFDSNSFLQNPSLRDQLALNEDLYIHGVRLNLEGTEAIYDLHLSLSSTGSNEDQIIFFLEDRTRSVTFVEDEESEEKLHEFILKISTPLDILKELSLSDKGGEGKSPARGLIMAYFDRFIHGVHHSQINFPSEEVPFRVEHISVAVEMCFESMMESRGLKLASVVGFESKFLIGDRLGILQVVFQVLGFLLTDQKSGHVQVNFNYLPKEEQLEVEISGSPDSNVYGDIVKAMENEGEFGISAEMTLQLLFDCRAVAYHEPVQVANLTLSKKEFPYLFGITGGDLSLVKDIFQTILVSLAMDMDDFEKAIAQEDWELIGRVAHKMKPNFSSLQRKDIAESLQHIEEITTGQDLAGLEEKLKDFIRSANEALENLKKYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTK5</accession>
    <name>A0A654DTK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024856809" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17021" checksum="919A84226DC2616B" modified="2020-04-22" version="1">MKTPTYSLLFVFLMSCGAINGPVADDMPKPHTEFINCFCDQYNSTTDWVYCTPVNVDLAGLPIESAVMSYSVRITRGGDVLEAELYDVKGQQAIPLTRVESVIGYVMHTRKTENIAGYLQDHAKELVIRFRVNREGAVGYISNGSGIQLTYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTR8</accession>
    <name>A0A654DTR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="19485" checksum="43250BBBFA203220" modified="2020-04-22" version="1">MKNYIISLTAIALIVLLQNCDDATNDDINVSPEAYSVSADDYTFHFNDEMYAEANARRANSKECNFDWSIESVSRVGNVLTVQVDRPKDCGVTYEIISGGVEFSYPPRAAIFVKAISQGCDSNGEYISENLTINMEEAYIHMSASDLKETLVNVRDFCSLNDISCDGECNVTVSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTT9</accession>
    <name>A0A654DTT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="17078" checksum="EA77816A328A2A9E" modified="2020-04-22" version="1">MSKQNIKNMTTKTTITIHTSIKAPIEKVWQLWSNPADITKWCTASPDWHTTRAENDLRTGGKFLSRMEAKDGSFGFDFSGVYDLVKTHEQMDYTLDDGRKVNITFAMQGNETTITQTFEPESENPIDMQRDGWQSILDSFKRYAEAQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTW5</accession>
    <name>A0A654DTW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="8321" checksum="A05AA9A695B10D4A" modified="2020-04-22" version="1">MIDEIIMKFIWYNPDLDAYQKGTMEDYSHLIGSSENGDRFDILYEFADSSDRLIDKILGSLNIVRSQKVATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTW6</accession>
    <name>A0A654DTW6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14039" checksum="6854D3A893B35456" modified="2020-04-22" version="1">MIKKILVAEDSSVIQNLTKKILSLQNYEISAVKDGRKVIDKLESETFDLILMDIHMPVMDGMECAREIRKMKNKNADVPIIAITGNANNYSLDDFKEAGINGYLPKPLNYDTLVETVKGYMVDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTY4</accession>
    <name>A0A654DTY4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="270"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="385"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="569" mass="64330" checksum="215F8AF675CD1F13" modified="2020-04-22" version="1">MKFVDLKIRNKLALVMILFALAVISLLSALYYIQFKEALKERVFLQLSSVKQLKVSQVRQRIEALVFDFLSNQAFAEQPDNAGVLIAEGFISQDTVISVYPLLFPEVIGSVVIQDLTPHDPKGQITLGLFKKEANRVRFGIFRPNIQSILMERTGLGETGESYLVGEDMTMRSSSRFFPERRPTDIVVKSQGVINALDGEEGYGLISDYRGVTVFSAYERLDVSNLTWVILSEIDEQEALFPLKSLRTNLIIVLGIILIFVFIVSYELSRQLVKPVLITEEQLRKMSKGIFESTFDVVKREDEIGQMFSALERLIAALKQTVVFANEIGSGNFEARYDLLSSEDKLGAALMGMKERLQAYQVSEKRLKLENQRSLISGEEKERQRLSQELHDGLGPMLTILKIKVESSTIQMDEKRELMRLFDETLGEMRKISNNLMPSVLRDFGAGEAIRNLVKQIGQDRLQVHYQYDPNVKISIPTNISIALYRVAQEAVNNVLKHARASVLNISLTEFTDRVSLYIQDNGQGFDPENVTLGNGLRNMRERINVENGIFELTSDSKGSVIEVEIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTZ3</accession>
    <name>A0A654DTZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="513" mass="58219" checksum="C2569FC31EAAA73D" modified="2020-04-22" version="1">MRADAAAPITQEQINQCITVLESLLGDTTQLFELPEEQRIALLKAAGALTRPDRAEFDKRRKDAKKAAKRKMVERDKHIRKTTGIRSARESVVFEAPKLISLTGKEHEAAPELESPRNCYVCKAVYTKVHHFYDAMCPECADFNYAKRFQTADLTGQVAIITGSRLKIGYHITLMMLRAGATVVATTRFPVDSALRFAKENDFKSWSHRLKIHGLDLRHIPSVEIFCNFIEHQYDRLDILINNAAQTVRRPAGFYKHLMANEEMNTNELPLLTRGLLSDHLYCLSELQELAPSKTKNQNLPVAWNAPEPGIGLRASAKLSQIPYSFDNSLQTQEVFPEGKLDADLQQVDLRKTNSWRLKLGEIETPEMVEVQLVNAVAPFVLCNRLSRLMRKENTGKKHIVNVSAMEGKFHRFYKEDRHPHTNMAKAALNMMTHTSASDFAKDGIYMNAVDTGWVTDEDPAELARHKTEVHDFQPPLDIVDGAARVLDPLFDGINTGKHWCGKFLKDYRPIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU70</accession>
    <name>A0A654DU70_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="394"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="615" mass="68674" checksum="AB9F324108E7EADB" modified="2020-04-22" version="1">MLTQLEEEHNLEDIQNKIIELALIIFSSLGIISLILNVIRAVYKNMTVVLTIHTSVVILLVLLLIFRNKVSHNLKAAGLLIAIYVVITVGLYQLGFVASAKALIVVLPVLTSFVLSHQKAILVSLLLLITYVIFGGLFVSGVFTDITYQTNYTSHNAVWLLDGAVIFLASFTLLFGSQIYRKAILHNFSVIRKHSAELITKEQKYKMLFETSNDAILLFDEGVFVDCNQKALTLFDCTARDIIGKTPIDFSPVEQPDGQLSKEKAPKFIQKAFEGVSQSFEWQHCKLNGEVFEASINLSLVALEEENYIQAVIRDITNQKNAERKIVAYQKGLEELVKARTQELEAANEDFRRANQELTTQKEMLSKTLSELRRTQEHLVETAKMASIGTLTAGVGHEINNPLNFIMGGLHNLECAIRQPESFEDDNELCAVQEEGLQTIKEGIGRIHEITKSLDHFNRSNQKKLGLCNLHAIINNCLQILNHEIKYKGKVLKTYHQQDILFVGNEGQLHQVFLNIISNAIQSFDKNGLITITTKLLTEQNLIEVDISDNGTGISPTDLDKVFDPFFTTKDPGLGKGLGLSMAHRIIQEHSGQINISSTTDGTRVVVQFPSKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUA5</accession>
    <name>A0A654DUA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="504" mass="54003" checksum="10D445E8616A1D38" modified="2020-04-22" version="1">MPTTIPYDPSLVLGNIVTLEKLTNIEQISQAEAPVNAAEDELNSLIAMKRSLDMTIQDMLNMNIDADQLVQESVKVGQSIQQAAINYAQVKLAAEQKIQPLRAKIAMINSSVESPMDYNKSQIKKMPLAADSLKMNCQYFGFDKNEQSSDAHASTIAGFVSDSLSLFGGYESGTGTVKSSVQQQVSSQHQNHSIAGTLVISINCTHKDALLLAPYILDVDKAIRVWNQEFPKDQLNVMSIASIIETMMAKDSQGENKLQLLSGATFGSCFVGMVHVLNTTETDSSQRMYSVAESIQGQFEVGGWWAHETGGFGVDSSFSNDAKNLLSTQNVTSHCTLTVMGSIPSIKANSVDMFVKEFNMNDDPLKGVQTLQGATTDEMNTISSSAEAARTGQQMIAMKSAGITSALSALSDSDKKSNQILDTNSMMDAMQDYINKCLAGNIGVPINYYLKPITKSELAGAWLKKYHPNKMNNALGSGDDSGDSSSSSGAGSGDSSSDASSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUD8</accession>
    <name>A0A654DUD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024936388" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="118" mass="13473" checksum="78F654DE92A99213" modified="2020-04-22" version="1">MKTISTLFTIALSILSTHLFAQDKQDDIIGIWQTQEAQVEIYKVDDRFIGNPINPEGERNTEIEVLNLKYENGQWVGKIYSKKRGSLLDVTCQVEGDKLLLEVTARFVSANLEWTKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT3</accession>
    <name>A0A654DUT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="337" mass="38000" checksum="0F6DFEEB34E4B0F2" modified="2020-04-22" version="1">MKKIPSLLTYFVIGFALALTPGCSLLPPLPDTVEQEVENALARGFDGIIVYVEQGGEPALYAAGWKNREDKIPADPHALFKIASISKLYIAAAAAKMVHEERLSLDKTLAEYLPELAGRIAHAEKITLRMMLKHRSGIPNFTDMPDYPWDNPPRDNREILELVLDRSAEFEPNKKYRYSNTNYLLIGAIMDSTLGHSHHQYIKEEILKPLGLNHTYSLLSEVDLDDVMSGYHVGYEPDIKYNDFIQPGGSMVATAEDVGIFLRALNDGSLFSEDEQAIYSSIYRYEHTGLLPGYQSIAQYHKELDAVVIQFVNTSGGSMWMKSEAVYRRVVRILKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ3</accession>
    <name>A0A654DUZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024834884" evidence="6">
        <location>
            <begin position="20"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="114"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="332"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="803" mass="89161" checksum="A56A3FF598D246F5" modified="2020-04-22" version="1">MKRSIMLWSLMTMACLGYAQVVTVQDLETGHPLELVTVVSNQHNALLTTNSQGQVKINPFIKASRIDFRMMGYKTISVSFDELELAGFLVEMSSSQVSLDQVVVSATRWSQTGQEVPSKIITITPKDIALQNPQTAADLLGGSGEVFIQKSQQGGGSPMIRGFSTNRLLYTIDGIRMNTAIFRSGNLQNVISLDPFATESAEVLFGPGSIIYGSDAIGGVMAFQTLTPQFSLDEKPLITGKAVTRYASANNEKTGHFDVSIGWKKWATVTSISSYNFGDLRMGSYGPEEYLRPIYVQRQDSLDVVVTNPDPKVQAPSGYTQINMMQKVRFKPNARWDFQYGFHYSATSDYARYDRHIRYKNGLPRSAEWNYGPQIWMMNNFTATNSQVNPLYDQMTLRAAQQHFEESRIDRDFNGDTRASRFEKVNAFSVNLDFAKAPGPKANIYYGLELITNDVDSRGTDEDITTGESVTGPARYPESTWSSYAAYLTYQYNLSGQWMLQAGGRYNLYALEADFSNNLPFYPFPESEASLADGAFTGSLGMLYHPGQTWSVSANASTGFRSPNVDDLGKVFDSEPGTVVIPNTGLSAEYAYNAELGIAKVFNETVKLDLTGYYTILENAMVRRNFTLNGEDSIMYDGELSQVQAIQNAAVANVHGVQAGLEVKLPAGFGFSTQYNYQRGEEELDDGTKSPSRHAAPWFGVTKLTYASGGLNIQLYAVYNGEKRFADLPEEEKAKDYLYAMDKNGDPYSPAWYTLNLKAMYQINDAFTVTGGMENLTDQRYRPYSSGLVAPGRNFILALKAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV02</accession>
    <name>A0A654DV02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein YfhO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="810" mass="90221" checksum="4A5A0774AA7850DF" modified="2020-04-22" version="1">MTNNLKRSILTHGAIILGFFIVTVIVYAPFFFESKQLAQHDILQGLGSNYQLKEYRAETGEEALWNNAMFSGMPAYLTSVQFPGDILTYVYQIFKLGLPNPEGITLVCFICSYIMLLSFGVRPWVAFAGAIAFGLNGFNIISLTAGHNSKIAALAFAPLVLAGIHLAFTRKKYLGIGLTSLGLAMQIYMNHPQITYYLLITVLVYGVFQLYYFWKDHQIKSLLLTLAGLILAASIAVGANSGKLWTVYEYSKYSIRGKSELKDESKESSGLDKEYAFRYSNGILEPLFLFIPNIYGGSSSQELSTQSATAGALRQAGYNGQQLRDQLKAMPTYWGDQPLTAPYYAGALSFFLFVLGIFVLDRRTKTWLIVVALIGIVLSWGSNFTLLNDLLFDHFPMYNKFRSVTFAICMTLLSINLMGFMALERVLTGMSDKAFRKKFLWSVAICGGTALLLVIAAGALSYRGSIDARLPEWLIDALRSDRESLLRSDALKALFFILAFSGLIWAYWKNSLKSVLIISGIILLLFVDIFSLTKRFLNKDSFENRPVKTYFKPTEADLYIRSIATSGERVLNLQNPFNEARTSYHHESIGGYHGAKMRRYQDLISACIQAEMSETINVLQSGGSQLPNTPVLNMLNTRFFLAGSSKNAVISNSRSLGNGWIVSNLKEVASADEELSEVCGINPSRTAVIDGSKFSPPNLIAGATGTVKLLSRTPNEIKYTTQTSGKSLAVFSEIYYPKGWKAYIDDQEAEILRVNYILRALPLEKGTHEIRFVFEPTSYYAGNTLTIVGEVLVFLLFIGGIWMERRKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC9</accession>
    <name>A0A654DVC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein activator LpoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014094">
        <property type="entry name" value="LpoB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13036">
        <property type="entry name" value="LpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024862820" evidence="1">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22393" checksum="AA40B21E6EFE0D25" modified="2020-04-22" version="1">MKIQHTFLMLVLVSIAVACTNRTVTRVSPDQQIDLSGRWNDTDSKLVADEMINDVLNRPWREDFSRANGRKPVVIVGMIQNKTSEYIEPETFIKDVEREFINSGMVRIVQNAVFREKLREERADQGEFASPETQSKWGRELGADFMMFGVITAVTDSYKNEKVVNYKVNLELANLETNEKVWIGDKEIKKFIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD3</accession>
    <name>A0A654DVD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="6807" checksum="294472A6EDD3F61A" modified="2020-04-22" version="1">MDFMDQDDLKLIGIIASIVIGLLGAGWFVNKNSNNKSNKSKQKNISINGNNNRIVGADDNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVE9</accession>
    <name>A0A654DVE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="40275" checksum="17DF4892B1FD8748" modified="2020-04-22" version="1">MMSQALSKTERFLKVGPHLLWFGMHAAISLVLAYQRSVAETIYYLVTYVFFGTIIIWLFGYKLFPEYLTREGKIDKKLGVLIAANILLFVLGIVSHTILAEAMELTPIRDQYAPKSVRIVLWVMMVFLGVIYMASIRVARVYYFNAVQKIEHKAQRVEAELKLLKSQISPHFLFNTLNNIYGLAYLKDERAAVMISKLSKLLRYLLYDCDQAKVRLAKEKELIENYLSIQLLKHEDAQNVDFYHAGIAQGHMIAPMILINFIENCFKHSDLESNPQGWIKISMEVENNELNFRTENTIREDVGETPMERKGIGLTNSLKLLEANYPEKHKVEITRENQVYQLDLKMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF2</accession>
    <name>A0A654DVF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein assembly factor BamD (BamD/ComL family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024896909" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1004" mass="114280" checksum="4230AF074D64D1DD" modified="2020-04-22" version="1">MRTGIFTLLLVVALSWRVQAQETLSNTPPDKFYDQGLDAFHREAYGAARNLFTQYLALSSNPVKEADYYLAISALRSGDAEGVSKLLTFIHQEPLHPLAGSGYYVLGSHFFAQNEFEEALKYFIQVSGSQLNAKDEEAWRFKQGYSYLETGNVTEAESNLEAVQNYRGSYFNESSYYLGGIYFDRGDYNQALTVLEALDGLSTPYADEVTMMIAGIYFHTNRYAQLYKYAGAQVSNKVSMKNKQLNKLLGEAYFGDQKYTSAASHLQKYLDMSGNRADAETFYKLGFAYFQTNENQKAIENFKKAGLEKGAMGHISSFYLGQLYLKERNLNYAYSAFKTVANSTEDGEMREESAFTIGKINFQRAQYAEAIVDFASFIDQFPNSRWKVEANELLAQSYLKTSNYDQAIAHLESIKNKSLPLKKAYQKVTFQKGQLLFNDSRFQQALLYFDKSTDFPIDTRIAAQAYYLKGECHTILNQSGQAGNAYRKSIETRDPQWSIYANYGLGYVYYNDKAFDQAEGYFLNYIRKANPTDDFYQDALVRVADCYYVQKKYEQAIRAYTEITDPQYVPYVTYQMGLVYRLKGEEAKAQSEFGKVLRNPLSGYGDKALFQMADMKSESGDFQGSITTVNRLLNDYPESNLIPYAKSQQALSHFNLGQYQESRKAYEFVLENYMGHQVANSALLGLQELVKKGVDIPNFDGYMEAYQKAHPDDNSLEVVAFEAAKGAYYNQKYRESIEKLKAFMSKYPNSPFEEDALYFLADSYYRNENWQQAADGFGEIIKIPGSAYVSRSLDKRGKALVNLGQFAQAIQNYHMLSQRAVNQKETFQAHEGLMNTYVKLNKSDSALFFADKILESDYKPANAEASAWLVKGKIYLQKKNYNLAVDELLKVMNDSKNESGVEATYLLGRVYFEQGKSKRSLEVLFDLNRNFGSYPYWIGKSFLLIADNYLAMGEILQARATVESIIANATIPEIKKEASQKLIKIKNEESKLLVSDTLKTDSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI8</accession>
    <name>A0A654DVI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="47" mass="5359" checksum="FC5C1C35C5FF740D" modified="2020-04-22" version="1">MIHTCPGRARLGCAALLYVSTFLNPKWISSVLQYITLETLLNDFIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ1</accession>
    <name>A0A654DVQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="37120" checksum="EAFFC5DC628415FE" modified="2020-04-22" version="1">MITVSILVPESSVMQAIADPQYLFSAANQFLAAAGKEPLFEVELVGAKKEIKLNEGRYSIHTDRLVQDIDRTDLVLIPALFGDMQAAIAQNKMLLPWIHQQYGKGAEVASLCVGAFLLASTGLLDGKKCSTHWGFQNEFRELFPEVEVMDGSVITEEHRIYSSGGANSYWCLLLHLLEKYTDRETAILASKYFAVDIDRDSQAAFSMFKGQKNHTDEAIKTAQDFIEKNIADRILVDDLANMMAVGRRTFERRFKLATNNTVQEYIHRVKIEAAKRQFENSRKNINEVMFDVGYTDTKAFRSMFKKITGLTPIEYRNKYNKMAEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ3</accession>
    <name>A0A654DVQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="117"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="41084" checksum="CD18B57E17071609" modified="2020-04-22" version="1">MLKDLINNKTFSIAIKIVAGFIVYFLLLAALVYVEKDSNQSAIRDMQNAVWYSIVTLTTVGYGDLFPATVYGRAIGYIFIFLSLGIYGLLIGQFTNLMATIQENKKLGYNGTTFEGHAVIIGWNEFGKMVLEQLIGVGKQVAIFTNNREDIDHIKDLYGTKNIFTLYGDFGSQELLKKTNIEQSSIVFVNLDNDTEKLVYILNLKKIFPNLDYVVTLDNGDLKNTFVSAGVTNTISKHEISSKLLASYMFEPDVASYSESIMSFARGDGDYDIKQLLVIPTNPYVGKAYQEVFFDLKKRFNAVLIGITKRDKYGNKRLIKNPLGELKIAPGDYLIIIMNGKAFKLLRKVFGVDEGYIRETSKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ8</accession>
    <name>A0A654DVQ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="7">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha,alpha-trehalose-phosphate synthase [UDP-forming]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Osmoregulatory trehalose synthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tpsp</name>
        <name evidence="14" type="ORF">MARINOS108_11066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="723" mass="83153" checksum="6330906D8A2E55B9" modified="2020-04-22" version="1">MAKTIIVSNRLPVKISQENGKYNYMPSEGGLATGLGSIYKDGDNIWIGWPGLAVSKADHQKEITKKLKTESMKPVFLTNTEIEEFYEGFSNETLWPNFHYFNQYIVFDDDMWRAYQKVNRKFARAIAEVLEPEDTIWVHDYQLLLLPEMLRESAPKASIGFFLHIPFPSYESFRLLPWRRELLEGMLGADFLGFHTYDDMRHFLSSVNRLAGLGNSNGMINVDNRKVMVDALPMGIDYDKYAESAAAKETLEREARYRESIGAQKLILSIDRLDYSKGIPQRLKAFELFLEQNPDYREKVSLLMVVVPSRDQVGKYKELKEEIDLLVGRINGNYSRLNWTPIHYFYRSFPLNALSAFYRMAEVAMVTPMRDGMNLVCKEFIASKLDKKGVLILSEMAGASKELSDAILINPNDMGELVNAIKTALTMPVKKQMANMISMQRSLQRYNIHHWVNLFMERLHHIKHEQKALETQLLDKTITSRLTKSYQAAKKRMIFLDYDGTLVGFDSDPLKTKPDKGLKTILAKLTADKKNRVVVISGRGRDTLEEWLSDFDLEIIAEHGVWIKERGKKFRTLTSLNDNWKGPIMKVLDGYVDRTPGSFVEKKDYSLVWHYRKVETGLGEARTRELTSHLKYITVDRNLKVLEGNKVVEIKNSEIDKGRAATVWLNKHPSDFVMACGDDWTDEDTFKVMPDSAYTIKVGTTSSAAKYRVTDFHDIRKLLKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT2</accession>
    <name>A0A654DVT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YkpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ykpA</name>
        <name evidence="5" type="ORF">MARINOS108_10759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="533" mass="59841" checksum="BDA2A0B87CF87B70" modified="2020-04-22" version="1">MISTQNISLQYGKRVLFDEVNVKFTGGNCYGIIGANGAGKSTFLKILSGEISPNSGSVHIEPEKRMAVLKQNHFEYDEFQVLDTVMMGHDKLWANMKEKEALYAKPDFSEADGNRVSDLEAAFAEMDGWNAESDAAALLSGLGIVEADHYRIMGELSNQQKVRVLLAQALFGNPDILILDEPTNDLDLKTIEWLENYLLDFKNTVIVVSHDRHFLDTVCTHIADVDFGAIKIYTGNYTFWYESSQLALTQRSSANKKAEEKKKELQEFIARFSANASKSKQATSRKKLLEKINVDDIQPSNRKYPAIIFNQSREAGDQILEIKGLTKSIDGNTLFKDFDLFVNKGEKIAFVGDNTLALTTLFKILMGEAKADSGTFKFGQTVTTAYLPNENAEFFKSDENLIDWLREFSPGEKDEVYIRGFLGKMLFSGQETLKKCNVLSGGEKVRCMLSRMMLQEANVMVLDDPTNHLDLESITALNNSLKDFPGTLLFTSHDHTFTQTIADRIIEISPNGFIDKLGTYDEYLESKRAAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY5</accession>
    <name>A0A654DVY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="12073" checksum="616635247E0141F0" modified="2020-04-22" version="1">MPDNMDFSYLISISDGDTAFIQEFISTFESNSTSIIEKLKISLETGNFDSNKKLAHQLKPSLEMLGLASLEIAVGIQEQPETVTLEQILQIESECKAAVQEMNNRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWA3</accession>
    <name>A0A654DWA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ORF">MARINOS108_10951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="119" mass="13980" checksum="9CFC0DA34B66CF85" modified="2020-04-22" version="1">MKRDYETVFILTPVLSEAQMKDAVEKFRGVLKDSGAEIVNDENWGLKKLAYPINHKSTGFYHLFEFKAETSVINKLETEYRRDEKIMRFLTTALDKHAVTYNTRRRKGEFNKKKEEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB3</accession>
    <name>A0A654DWB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase B</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">MARINOS108_11245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="554" mass="62629" checksum="F602980D946B2CA5" modified="2020-04-22" version="1">MCGIVCAFELKQKAEVLRPRLLEMSKKLRHRGPDWSGIYSSENAILAHERLAIVDPASGKQPLFSDHQKIVLAANGEIYNHRELRKQFEGKYHFSTASDCEVILALYKEKGASFLDELNGIFGFALYDSESDAYLVARDHMGIIPLYMGWDEDGTFYVASELKALEGVCTKIELFPPGHYLHSKEGKLVKWYERDWTAYENVKDSETSIEDLHDALEAAVKRQLMSDVPYGVLLSGGLDSSVTSALAKKFSQNRIETDGKTGAWWPQLHSFAVGLEGSPDLAAARNAAEHIGTVHHEILFTIQEGLDAIRDVIYHLETYDVTTVRASTPMYLMARVIKSMGIKMVLSGEGSDELFGGYLYFHKAPNAKEFHEETVRKLSKLHQYDCLRANKSLAAWGIEGRVPFLDKEFIDVAMRLNPQDKMITPEKMEKWVVRKAFENYLPDSIAWRQKEQFSDGVGYSWIDTLKQVVSEKVSDDQLANAKYKFPVQTPRNKEEFYYRTIFSEHFPSDTAALCVPSVPSVACSTPEALAWDESFKNMNDPSGRAVGVHTDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK3</accession>
    <name>A0A654DWK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SusE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025970">
        <property type="entry name" value="SusE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14292">
        <property type="entry name" value="SusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024865393" description="SusE domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="SusE" evidence="2">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="409" mass="45732" checksum="8E647F402A174DCE" modified="2020-04-22" version="1">MKKIRKYSVLAMVFALMFFSCNKEEFELNSEIAQVGSLEGPVNDTRIQIDPENGESVTFNWTPAQAADGGLILYTVLFDVESGSFEEPIYSISSDNKGGGTTLTLSQVFLNIIAAKAGIEQLTTGKVKWTVKASSGYQSKVFDQSLELSLTRPEGLAIFPKYMYIHGSATEGEELSDAVAFKEIVNELPTDNFNPGVFESISKLTPGEFYIVDSNNPDSTVNNYYLNSEGKIRSGDQATSFTGEEGVYRIRMNLSAATISYEKISDLELYIFASQVTKAELSYVGNHTFESTNGFFDFLNPGDPEAPDWLGWEEERYRFKFMIDGTQTYLGSFHNEAMNASLVEGQSAYNVRPTGEEPVSYYNVYFLGADAGYWQGAWKFADEYNGAPFTVRVIFDPKADHYYHEFELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX8</accession>
    <name>A0A654DWX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="501" mass="55950" checksum="F1C14DEA41D25B7C" modified="2020-04-22" version="1">MSSTYPTLINDLMKKLNLTLLILFFTFTAFAQSDSLYVLDLQQCIDIAIENNLSVRRSNLQEQLAQVNLNQSRASQLPSLNVGGNYGYNWGRSIDPTTNSFITQQINFTGVSGTANMTLFNWFRITNTIKQNRMSLESSQYAVDKAENDISLNVVTFYLNVIFNRELFENAEYQLRSSQEQLERTKKLVAGGALPRTNELELISQVATNEVQLVTAQNNLDLALLSLKQAMLIPTSQDIELIIPDLTLEGEADLTISSDEVFEAAVASMPEIQSAELQVQSALMGVKVAESGYAPTLSLNGSFRSNYSDAYKQYNIDEDNPYTINRDASGNVITNPTFYQTNDGTPVEEISISPNGSLETVGFGDQMNQNFSKSLTLNLSIPIFNNLQAKSSVQNARINLQQAEITVLEQKNLLRQTIETAYNDAFAASKTYAASSRQVEALEETFRSVENQYNLGAANFTDYQVASNNLFRAKSDLVRAKFDFIFKKKILDFYQGNSLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY0</accession>
    <name>A0A654DWY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024906155" evidence="5">
        <location>
            <begin position="21"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="154"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="315"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="798" mass="90106" checksum="78FAE763745269FE" modified="2020-04-22" version="1">MKIKYLALTLFISLSMTAVGQDIITINGKEFSGNKGYIYGKLMDKETGEDIIGAIVSIPAEKEATVTDINGEFRLRSPKGEIILEATSVGFEVSTFRARVLGSGNFRLYLKPAMTQLSEVVISGSKGDANVKSTDIGKNSLSIESIKELPMVMGEVDVIKSLTLLPGVSTNSELSTGFNVRGGGSDQNLVLLGDVPIYNPAHLFGFYTAFNADVVDDVSLYKGGVPARYGGRASSVLHVKYRDGDYDKWKSNLSIGVVSSKLAIEGPIIKQKLSVLGSVRRSYLNYTLKAFDDPDIRESSAGFYDFNVIANLKLNNRNKLTYSIYKSSDNFNLAGDTVYQWVNFYQAANWYHSFSDKFSLKATGALSTYSNTIENRSLVNPYKLNTEINNQILNLDLEYIFNDQASLNAGVNFNRTMLQPGELKPNDPETSTINAEKVQEEKANEIAYYLDASYEITPRLSVTGGIRYNTYNYLGGHTIYYYEPYRERIEETIVDSLHFGDNESIQTYSGWEPRFTARYTLSDMSSIKLGYNRMYQYIQLISNTTTIAPNDIWKLSDNYLKPQISEQLSLGYFQNFNKNKFETSIEGFYKEIDNVVDYKDGAALFLNDHIETELNSGQGRSYGLELYLKKNSGGRLKGWISYTYSRSLRKIEGPYKTETINGGDWYAANYDRKHNFTNVLIYQLPKKWEFSSTFTFKTGQPITYPAGKFEYGSSVLSLYTDRNTERAPLYHRLDISFTKKFYVFENKNAEFNFSVYNLYGRKNPFSVFTQDVVGSPPQAYQLAVLGVPFPSISFTFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX69</accession>
    <name>A0A654DX69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gliding motility-associated-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025036430" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="139"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="246"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="346"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="447"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="549"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="638"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="745"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="848"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1428" mass="155037" checksum="4414582C85EC3147" modified="2020-04-22" version="1">MKNIILMILVLSGAMSYGQAPGSWTVDPNDFTYDMAITARLEVNGRVSTSSNDVVAAFIDGVVVGVGSPDVNVPSTGEVVIFLTVYSNSASGKTVTFQIYDDQNNEVLNAVNSLAFENNAQTGSNTVPYVISDNYAPTAISLSASSISENLTAGSVVGVLSTTDANHSTGFTYQLVTGEGDTGNSFFTITGNELKTAEILNFEVKNEYSVRVQTTDPKGATFERAFVITVLDVNDGPTDIILSASTLAENNETFAQVGLLTTTDEDAGDSFVYTLTGSADDSNFEIRDGNRLVLGVVANFEVKASYSLTITVTDQAGAGLTYQESFVVNISDVNEAPTDITLSNNELDENSPTGTILGTLTTTDQDLSAGDTHTYTFINGTDSNGDFLLDGNTLKAVVVPDFEEKSTYFLTLVVKDAANNTFTKQFQINILDVNEAPNDIYLSKNALAEDAAIGTFIGRLSVNDVDDVDTYEYAFVSGDGDTGNALFQITDDEISSNGTFDFEVKSEYEVRIQATDAGSNTFQKVFTIVLLDANDPPTNLKLSKSDFYENNTIGQEVAVISVTDQDATDEYVYSLIGTDHDGYFEINDNKLYVQQVIDYETNTTLTVTIQVTDDGGAGFSYQKQFVLTINNRNEAPTEIFVTNLSIPEDMAVGQKVADLSAEDSDNVFGEVHTFSFSSGEDTDGPFFIDGSSIKLAQKVDFESVSSYFISLMVTDKAANTFVQQFQVTIEDVNEPPNDVYLSKNTLKEDATPGTFIGRLSVNDVDNPDVFTYAFVSGDGDTNNDLFLLEDDVFLSNGTFDYEVKSEYEVRVQATDNGSNTFQKAFKINLTDANDPPTNLKLSKSDFYENNTIGQEVAVISVTDQDATDEYVFSLVGSDHDDFFEINDNKLYAQQVVDYETNTTLTITIEVTDAGGEGFSFDKEFTLTINNRNEAPTAIMVSNLIVPEHTGVGQKIADLSAEDTDNAFGELHTFSFSNGNDTSGPFFIDGNTITMAEKVNYEVKSSYFIALKVSDKEANTFVQQFTITISDENDVPTAVALSGNTFDENLPVGTEVGEFTTTDEDAGETFTYALKAGAGGGSNALFSIEDNVLKTAQVFDFEQTGSLSVRVAATDGDGAVIEKAFALTVNDTNDAPTGILLSNDVVDENQPSGTLIGVLSTDDTDASDSFSYTITGADAEQLKKFFKISGDQLQTKVPLDAEGQGQFALEITVTDKGQSTFSENFVVLVESVNEAPVLADTTLYITENSESESSLGFLNVTDVDGDDFTFEIIRSDPFFDESKGAFRIDVSGQVLVNNKDSLDYEELKEVIYRVRVTDSGSPQLTVEALLRIEIQDAVESDLLPVNEVITPNSDGYNDYFFIQNISLYEGYTLVIYKGSGVEVYRSTPYANEWDGVSQNGKDLDPGVYYYKFYSSLGNLYRGTVTIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE5</accession>
    <name>A0A654DXE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SiaC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="143" mass="16434" checksum="F65F326242B0CDCC" modified="2020-04-22" version="1">MNAYSLSPSINEVSPTTNSNRKLLSINFLENKSLLIIKGWSLTPELRTVYSVILEEIQDHLAVNEGITINFEYKIFNAFTAQFLFKAIKTLNQAKAQSKQVNVNWIAEKYNTEIYEMGMDLKELCEFDFNVNLKHHTISPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF1</accession>
    <name>A0A654DXF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-6-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="75" mass="8645" checksum="3498DBD0FEFFDB7D" modified="2020-04-22" version="1">MMNVCAATMYIIKVKGKAKIPDYIQLRDDKFVLIAYFRADRPLQKLEKFGLEGKEAELKAVIDELPFGKLQKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK5</accession>
    <name>A0A654DXK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exostosin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin" evidence="1">
        <location>
            <begin position="156"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="303" mass="35725" checksum="B0334E5AE1AC48C1" modified="2020-04-22" version="1">MGNLKSRRVRKFWKAPINRKLDIFDYRYKTLFPYLSGDTFRAIGEVIIDKSSHNPTIPKKDSPLIVYAIQTRPGDFVNIFFDKIIHKIDQEFVLITHNGMTPDWSKYEKHLDDDRMLAWFGKNLVYDHPKSHTIPLGITNQRDPHERGGSQEFWNQMRATPPEKDITCYVNVGIGHKKQARYENRLQTVNYFKAQSFATCVGERSWLQYAQEMHRSRFVIAPPGEALDTFRLWEALYLGAIPVVTSTPLDPMYREFPVWIVEDWEEVTEEALEKKWLELSPQFNNLPQLWAGHWYKKILSFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM1</accession>
    <name>A0A654DXM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4487" checksum="412D840D5C49E577" modified="2020-04-22" version="1">MNGLLEPNGDNGGDRQENLCDMTMNNILPFLASLLYNPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ6</accession>
    <name>A0A654DXQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024975843" evidence="2">
        <location>
            <begin position="24"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="867" mass="90623" checksum="81494E76406397BE" modified="2020-04-22" version="1">MNDKIRVLLMVSLVLLAETKGLASQQGPNGPGTSTTSGSTSYNWSNPSNATFDNTSAATASIVGAGNMTNTLRLTNFGFSIPVGATINGILVEIRMQGANGKTQDQTIQLRKSTGPVGTNKARKNSAWPKKNPRYIRFGGSSDLWGTTWTHSELNNTAFGIDIVAKSRNGTAAPRVEYVRITVTYNQISYYSKSTGDLHTLATWGTNTNGTGTAPSSFTADGQVFNLRNRTTAALTGNLTISGAGSKLVNGDGTNAINFTIPATFAYSGMVDVSNNATITINHLTVPTFGTISRGSNGGASTVVFGASGSQSIDGRAFHHLTISGSGTKTLTGTAGAEGKLTIGSGSTFSDGGYIFTIDGNIENSGIHQSLTDGVIIMNGTASQTLLGSAGVYGHLEIDNTSGVTLTTSTTVSGTLYLTSGALSIGANTLNLSGNTQVTGGTLTGGASSTLNITGTGSLGTLSFTSGAQSVNHFTLNRTSGDVTLSTPLTINTTLTMTSGNILNGANALTLGTSTSSRGTLNWTSGIVTGSFTRWFTNATNAGTTGLFPIGTSTDYRPARINFTSAPGTGGKLTVQFVEGHPGNAGLPLSESGGNIDRIGVTGVWGISATTLSGGLYTADFTATNFVGVDDYTKLHLLYRTNSASNWALNGTHQTTTGSNAAPVLQRTGMSGFGEYGVGGDQTDNSLPVELLYFKMLQKGNALALSWSTASELDNDYFELEQSLNGRDWLMLAQVPGHGTSDIQHDYMLETKAPSVGTYYRLTQFDFDGKMERLGTLYYTRDERNSASALNLYPNPARAGGEVCFIDHQGGEIPGTVMLRSIRGGIIRVIDQNNEGYFILPDALPSGVYLLSWTVGGKVYSSKLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU2</accession>
    <name>A0A654DXU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014541">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43224">
        <property type="entry name" value="PTHR43224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028188">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="311" mass="35464" checksum="B470280576A8CC6B" modified="2020-04-22" version="1">MSKQITNTLMMIRPVAFHMNEQTAVNNYYQKTIAGLSKEEIQENALSEFDGFVKKLRAEGVEVLVFDDTLEPETPDSIFPNNWVSFHESGEVILYPMYAENRRLERRDDLLADLGKNFNITTISGYVDWEAKNKFLEGTGSLILDRQHKIAYAALSERTHPEVLKEFQKHTGFDIVSFQANQTVNGERLPIYHTNVMMCLGEEFALICAQSIDDELEKSAVIRSFENTGKEVIFITEEQKERFAGNMLQVLNDKNERYIVMSESAFKSLDEAQKDQLSKHGKLLYSSLDTIECLGGGSARCMMAEVFLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW9</accession>
    <name>A0A654DXW9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbD_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="227" mass="24679" checksum="1A24B943015EB7E7" modified="2020-04-22" version="1">MIAAFVIGLFGSVHCVAMCGPLMLTFTGTNGKNTFISFGLYHSGRLLFYGFIGAIFGLLGFSVRFFEVQQYLSILLGATILVVYLFPRIRTRIEGAYHRSWFFQSLKNVLTKYFSTRMRWFAAGLLNGALPCGLVYLAAAGALLSGGLTGAFFYMILFGLGTLPILAAFRFVSHYVPGLSHRLNNLITPVGLLAGIVLISRGVLAVAPDVNQLIKAQIMQVMTACGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY1</accession>
    <name>A0A654DXY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative PurR-regulated permease PerM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="363" mass="39911" checksum="D4A0CD7B804B6517" modified="2020-04-22" version="1">MKRTLVAIGVFVVLLGVAIWYFSNIFIYLTISLVLATVLRPMTSQIIRFEVFGGKVPRYIAIFGSYAVVIGVLALFLVLFIPLISNQLEVLASLDFSTVFDSLVQPVRWVETFLINNRLSDGPSGFMVDSVRKGVVDFIHTMDFTEILNQLISFTGNFFIGVLAVGFITFFLLYENGILRRQVIAVIPNKYFEVFISALYKIERLLSNFLLGILFQMISIFSIAAVGLSIVGVNYALTIAVFAAIANLIPYLGPLLGGIFGIAVAVSTSGDFTFNNDTLILVAKVFSVFAVVQATDNLLLQPLIFSKSVKAHPLEIFVIIFVGATIAGIPGMIGAIPVYTVLRVSSTEIYAGFNQYRVFKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY9</accession>
    <name>A0A654DXY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="27850" checksum="0167F266C98D517C" modified="2020-04-22" version="1">MDLHLKDKVVIVTGGAKGIGEAIVWNLVHEGAIPVIVGRASSASASLKAQIDEQGGRSHVINTELGKGDVCEGIVKEVVQEFGRIDGVVNNAGVNDGVGLVNGSPDRFRESVIFNLTHYYDLVHYAFPYLKESKGSIVNVSSKTAVTGQGNTSGYAASKGAQLALTREWAVELAPFGIRVNAIVPAEVMTPQYENWIKTLGNPDEVLAGITSKIPLEKRMTTSDEIGAMTVFLLSERSSHTTGQWLFVDGGYVHLDRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY73</accession>
    <name>A0A654DY73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Nuclear pore complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16201" checksum="5AB13059512F338E" modified="2020-04-22" version="1">MNTLAQILPATQTPAIEDKKLLKISFIEKKNFLSIKGWSVTPELKVVYAVLLEEIQDHLASYESITINFGYKIFNPFTAQFLFKAIKTLNQAKAQGKQVNVNWIAEKYNTEIYEMGMDLKELCEFDFNVNLKHHTISPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY82</accession>
    <name>A0A654DY82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="57"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="354" mass="39038" checksum="1C20AC17525468D8" modified="2020-04-22" version="1">MNKNIKRLLYIIIALVILGLIAYPKIPKGGDKANKAVQAASGPQITVDAVILKKEQLKNQVNTTGSLLADESVTLNAEVAGKIEAISFTEGQKVKKGELLLKLNDEEILAEIEKLRFTVKLNEDNEFRQRQLLEKEAISSEEYETALTTLNTVRSEIKVLQARLEKHYIRAPFDGTVGLRSISEGGYLNPGTRVAELYKINPIKLEFTIPSKYIGVVNVGDRIDFTVDAYDQSFGGTIYAIEPQIDPQTRSIRLRAKADNTGGKLFPGQFARISLTLEVIEDALLVPSEAVIPELNGKKVYLYREGVVNSKQVTSGIRTENRLQIISGLNEGDTVISSGILQIGQGMEVNLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG3</accession>
    <name>A0A654DYG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="57"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="35593" checksum="8B9BD06F02F59962" modified="2020-04-22" version="1">MTNTYRRQFVKNISLISGIALGLPSQAMSLFNGERSLKVNIFSKHLQFLNYGRMAEVAKMIGFDGVDLTVRPNGHVEPANVQKDLPEAITAIRNEGLSFETITTAVEDALDPVDRSVLETAAVLGVKTYRMNWFRYDQQVSMMDQLQSLQKQVADLGVLNERLGLIACYQNHAGNLVGASLWEVYELLKLSDPKFFGVQYDIRHATVEGGVSWPNGLRLVQSQVKSIVLKDFKWEKIGGKWILVNTPIGEGMVDFPAFFRLIRKYEIEVPVSLHLEYPLGGAEHGHRQLSCDQGIVFEAMKNDLNRVKQYWEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP7</accession>
    <name>A0A654DYP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_12169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025052889" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="671"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="763"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1092" mass="116213" checksum="19ED4A36025586DC" modified="2020-04-22" version="1">MRKQLLAMTLMGASLLTYAQSERKPAKDFKSPQLISVQEVPNQNAKTLLREKLQLQNADDMQLMKSEMDQIGMKHEKYQHYYEGVKVFGSEYTVHSKSGKISHLSGKLAKVENVDVKPTLSEQAALDKASSKITAEKFIWDEDFSKKPKAELVILDAATTGKDEARLTYKFEIISLRPYQRYDVFVDAKSGETLMMYSKIHFADAVGSAATRYSGTQTVHTDSYSGSYRLRDYSRGNGVVTWDATTATGVNNSTGVPIGSSDYTDNNNSWTAAEFDNADKDDAGLEAHFGAAATYDFFSTTFGRNSYNGSGATINSHVNTDIEDVYGYPSGYNDNAFWNGNVMVYGKGNSLDPLTTVDITGHEIGHAFMEYTAGMIYQKESGAMNESFSDIWGTCVENYTNVNYGTNKDLWNLGTEIGQTFRSMSNPNAHSQPDTYGGTYWVSVTSCSPNSSNDYCGVHTNSGVGNHWFYILTVGKSGTNDIGSNYSVTGIGIDKAAAISWRSQSVYLGANSTYADWRTFAIQSAKDLYGADSPEEIAVTNAWYAVGVGAAYSAPVGCVASPLSLSITFDNYPEETSWTVKNSGGTTVASGGTYGSQPDGSTLNLDINLTAGDYTFTINDSYGDGICCSYGSGSYTLSSGSTTIKTGGSFSSSESTNFCISSGADTQAPTAPTGLAASNVTQTTLTLTWTASTDNVGVTGYNVFQGSTNIGTVTGTSANITSLSSGTSYSFHVTAVDAAANESASSNTVNVTTQSPDTTAPSVPTGLAASGVTQTSLTLSWSASSDNVGVTGYDVYRDGSLYTSVSGTSTSVTGLTASTTYAFRVRAKDAAGNNSAQSTALNVTTAANNVTYCTAKGNNTNYEWIDLIQLGSINNSSAANGGYGNFTSQSTTLVLNSSNTIYFSAGFASSTYSENWRVWIDYNQDGDFSDSGEQVVTGTSSNGNTYSASFTVPGGAALGSTRMRVAMVWNATPASCGTFSYGEVEDYTVNISATSINGIAAASSPSFAESLDHELSEASFGVYPNPVGAVLNFNTGDFKVISGLRIIDLGGKEMRRLSGNANALNVSDLHPGLYILEVESERGKFQTKFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT5</accession>
    <name>A0A654DYT5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">acnA</name>
        <name evidence="11" type="ORF">MARINOS108_11544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="10">
        <location>
            <begin position="710"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="911" mass="100811" checksum="D17E45B0D60A61E1" modified="2020-04-22" version="1">MTQDIFGIQRELSTPLGKHKYFSLKALSEKRSEVKSLPYAIRILLENAIRNYDNFSVTEAHLESLLGWQKTAGKDDIPYSPARVLMQDFTGVPAVVDIASIRSEVARKGKDTEKTNPVVPADMVIDHSVMVEYFGTQSSYRKNVDLEYQRNDERYKLLKWAQKAFTNFGVVPPGMGICHQVNLEYLAKGVIERDGYLFPDTLVGTDSHTPMVNGIGVLGWGVGGIEAEAAMLGQPIYMILPEVIGLKLTGKMREGATSTDLVLTVTRLLRDYGVVGKIVEIFGPGLEHLTVPDRATISNMSPEFGCTDTHWPIDDQTLAYMLKTNRSEAHVEMVKAYAQENMLWRNPQDDIQYTDQIELDLGTVEPTISGPKRPQDKILLKNAKSQIIDLLKESHSRTYIPVMERSGNWANEGGTTAEPVTVSSGIRSVPLKKDDISYNLSDGAVVIAAITSCTNTSNPSVMIGAGLVAKKAIERGLNVKPWVKTSLAPGSRVVTDYLTKAQLLPYLEGLKFHTVGYGCTTCIGNSGDMIPEVQKAVIENDLVVCSALSGNRNFEARIHPNVKMNFLASPMLVVAYAIAGRMDFDMNNEPLGTDPNGQEVYLRDIWPSQQEINEIMDVVVTPEDYKRTYETIFDGDEAWTKLKAPVGNIYEWDEQSTYIQEAPFFKNISEEVPTPQDISGARVLLQLGDMVTTDHISPAGKFLPEHPAGLYLTQHGVSPKDFNSYGSRRGNHEVMMRGTFANVRIRNKLATKEGGWTIYHPTGEEMTVFDAAMKYQKTDTPLIVIGGKEYGSGSSRDWAAKGTTLLGVKAVITESYERIHRSNLVGMGVLPLQFMEGETQDTLGLKGDETFDIHGISTDLTPGKIVDITASNPQGDVVKFQAKLRLDSGVDVEYYKHGGILNYVLRHFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ9</accession>
    <name>A0A654DYZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="445" mass="49110" checksum="2302B94C7D5F0F0A" modified="2020-04-22" version="1">MNQKLLMNLYIAIEAVLANRMRSVLTGLGIIFGVAAVIAMLAIGNGAQQEILDQIKLVGVNNIVIRPVVPQSEEKLTDEDNKGQTQKFSPGLSSKDTEAIRKVVPGVSMISPEITLDTYIINNGFRRTAKLVGVEPAYFQIFNFELDKGDMFSEHHLISGEPVCIIGKSIKAKFFPTEDPIGKYIKCGNNWLKVIGILKERLISKNSISNLGIRDYNMDVYVPLQTMLIRYKNRALVTTEMLRRANSFNDDDEEAMKNQDPNYHQLDRLVVQVDETAKIGATADVISRMLQRKHYSVVDFEIEIPELLLKQQQRTNDIFNYVLGAIAGISLLVGGIGIMNIMLASVLERIKEIGLRLSLGAKKFDIINQFLFEAMMISVSGGLIGVILGVSIAIMVSAFAEIPTVITFSSIVLSFGVAAAVGLIFGIAPARRAASQNPIDSLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ68</accession>
    <name>A0A654DZ68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="391" mass="44759" checksum="E6974FAF8CE1C618" modified="2020-04-22" version="1">MRNYIVWLGLFWMVLSVEAQSKYQRAEELYEKAQQEYRTRNYHEALDLVNQSMQLAPTADAAYLSGLVHEAMGRDLRAVSSYEATLKLDPRYDEAIFQKAIIYLNYGDPAQAHADLSVLINTEGITQTRGVYFQLDPSGQEQNQILSVNNLRSKLFHYRGQASEKMGEYDEALADYNEALMVDTLATYLISRALLHEKMDNQAGALADLKLAITLDRGNQLAWYNLALLDPSVVLPDDLLEDESFGPTLSLLASRAMSEGNYILAKKYFDKSIQNDDADALSYINRGRILLKMNQFVLARADFNHAKALEPERIEIYYLIGNSFFYEKQFERAAAYYNQYLTADPTNGMVWYNGAMSYLELDNKEEACHYLQRANTLGMLQAEKVLKKYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD6</accession>
    <name>A0A654DZD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="29445" checksum="81D21FE3980B444D" modified="2020-04-22" version="1">MKRYAHFNMIMMVSLLLTFGCKEDGLFNKEIDNTPANIKILYPQANTVNYITSIGYADYMVFLLSDPEKNGKRLTVTGIGTVTLELNDNPIYYDDVPDTLFGLSPIIYANSDNLIQLYVEVEDKGDRNTLSDHTFSFTMVPDNAFITNPKLTRTEDLSVEFDVHTFSKDLGSIVSFNFTTVDVNAGAIYNFGQHEYYSAMNEINCNNCHTSQPSLTSHFSTHLIGKDIKSGNNLYVHIYVIDHKNSNGSHTNYRYPLGVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG9</accession>
    <name>A0A654DZG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin component YwqK of YwqJK toxin-antitoxin module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024896911" evidence="1">
        <location>
            <begin position="19"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="51017" checksum="B0D23029DAABCA19" modified="2020-04-22" version="1">MRILLLAFSILTLRPLLAQDPELDPNQRVFQTDTLPDGVYRSKYEDGTRAFVGAVQNGQKTGVWKYYNQNGTLKEIIEYENGVKHGLNRKLDAYGVLINESTYEKNVLNGPYKEYYDNGKLALTGYYRNGQQDSTWIEYFPEGNVNFVKKYKNGQLNGKSLFYYSFGRLKAEEYYTNGIESGTWKIYFPNKQLRKEFRFKNGLLSGAYKEFHESGAKSVEGQYALGLKTGKWLSFYEDGTLFSIGDYERDQKTGLWKYFKANGALDYEGQYQNDLMENQWIYYYDSGIPRMIGSFVHGDEDGLWGLFYENEQLKQEQVWKLGRLMEVSPFFTIQGEELTPGTLKNGTGTLLSYHQDGTIASEEELINGKKAGVARYYYEDGTLKETGRYLTGLQTGEWRQYHPNGKIAAEGQYTKGLMTGIWSFFNTRGRLIDTADYSEVQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR7</accession>
    <name>A0A654DZR7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="374" mass="42820" checksum="AE995F4FAC490C69" modified="2020-04-22" version="1">MRVILFLIRKEFLQIFRNKSILPLILVMPVIQLFILSYAADFEIRNVRVFWMDDDQSTSSRMLLQKIQASDYFQLVDQSFSPKAADLALVQRKTDLVIHIPQEFEHNLFREGHADIQLTADAIDGTKAGLGTYYANLLIQDFSRDWLAKYGSNIHIQAASMPSIVPTYSFWYNQHLNYKTFMVPGILVMLVTMIGAFISAMNIVREKELGTIEQLNVTPIRKYQFIAGKLIPLWILGLFIFTIGLVVAKLAFHVPIIGSLFLIYGFTAIYLVMILGLGMLISTFTNTQQQAMFISWFFLVIFILMSGLFTPIENMPSWAQNLTLINPIRYFIEVIRLVMLKGAVFQDVGLQFVVIGLYAIIINGLAIWNYRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW9</accession>
    <name>A0A654DZW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator rcp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rcp</name>
        <name evidence="3" type="ORF">MARINOS108_11119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="16430" checksum="B30EE2BCA0B3F868" modified="2020-04-22" version="1">MRKPVHILLVEDNEGDILLTTEALEESEIANKISVVRNGKEALDWVFKRHQHENSEAPDLILLDVNLPLKNGHEVLQAIKSDDNVKHIPVIMLTTSSSEKDVHLSYQYAANCYITKPVEVSDFLNAISTLCRFWIKVVTLPKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E088</accession>
    <name>A0A654E088_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhzF family phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="33440" checksum="1B331C0DF7BA0FE6" modified="2020-04-22" version="1">MSIKQAEYYLLDVFTDEKYGGNPLAIFPDASAINEHLFQKIAREMNLSETVFLFPPKENSNYSMRIFTPEKELPTAGHPTVGTAYYMARMHNLAKEGSLKITLNQPIGAVDVFVEFEDHHPAMVTMHHPLPVFGPTHNEKAWQVAELLSLDIEDLDDLPIEEVSCGNNTLIVPLKSVEALGKIRFRPHLWDNLRSEFNKSIVYTFTKTGVKEGDVQGRMFGPEVGILEDPATGSANGPLISYLTKHQLVSGPILSLQGCEMGRRSKLHLDADVDSQGNITAVKVGGKCVFVGKGFHFLELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H5</accession>
    <name>A0A654E0H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="18329" checksum="14B40786516CF149" modified="2020-04-22" version="1">MKKPLIAFIWFLACACTPPPSQQPLENFGPFTGATVSCGHLQIFVLNQSGTGYLRVFVDDRALPLGRENTFRVGEDGLSVEYRAFDQDISSMLCNDVMPSVKPRELQRVPATTGVVYITLSQEDLDLYLKGVTYRVNVVLNDVSIDGLAEPLSFRLEGMVVGWLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K0</accession>
    <name>A0A654E0K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase YrrM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="212" mass="24298" checksum="7CFD25027CD87EB1" modified="2020-04-22" version="1">MDFLPTELQKYVEAHTSPETELLRRINRETHLNILKPRMLSGHLQGRVLAMLTQMIRPRYVLEIGTYTGYSALCMAEGMQPGGKLVTIEVNEELATLTQGYFAESPFDELIDFRIGDAQEIIPTLSYTWDMVFVDANKETYPQYFELILPQLRKGGFMIIDNVLWSGKVTTDDQKDKATASIKAFNQMVHDHPEVENVLFPIRDGLMVLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K8</accession>
    <name>A0A654E0K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="PTHR46044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="19398" checksum="A545AD94EEA8A0CE" modified="2020-04-22" version="1">MGHGRWKWSGDSFIGPIHGIGGLNCWENWLPLARATLYAQGEDLHVSVWPGNDRNTRDLIPMIARESRSYVVAACGLFTDKDITDDLPQARLMKDQMSGTLANGGSCVAAPDGSWLLEPVIDQEGIFYVEIDHQKVRAARLTLDVSGHYSRPDIFQLEVNQQRASILKKPQKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q9</accession>
    <name>A0A654E0Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="286"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="659"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="790"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="836"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="987" mass="110139" checksum="E5895FFD5783674B" modified="2020-04-22" version="1">MIELLKITGLVSAILLASTVAIYYNFKGSFLFRICVFFVALSAELCIVSYASGMYGIVYFLYASPIIVLQFYLGMRFIFRYVHYPLYRIIKRINMMSDGNLDIDFQELKTDRRKDEIGHISRALDSHLMFLKNTAGLANEIREGNLNSEFSLKSNNDLLGQSLLDMRDNLRTMLGGVDEVVSMAGDEGKLDVRIDNQNKSGIWLQLGNSINELLENVSRPFYSINKIVNAMASGDLTHRYKEEAKGDILKITNNLNLALDNLDGLLHQISQNVLTIEESTSEMRVTGEEMNSNTNEIASAIAQMSSGAQNQLAKVDESSSLVEEILQASQRMVQKAEAINNAAKIGAESSEKGIGIVNGVVSSMVEISEYSTKTNQSIQVLTQRSQEISRTLSVITEIASQTNLLALNAAIEAAQAGDAGRGFAVVAEEIRKLAEDSRKSAKEIEILVGDVQTDTEVAAKVMSNMNMVVKSGEETSRSAAASFKEILDSSTETLRFSEEILNAAQNQIQSINNVVSITESIVVIAEQTAAGTEEVASSATELSSGMGSYNDKTQNLAQIAMEFKEGISMVRLSGQAKENNALFQMREAYEKEKSLLDALLSNIPDFIYFKDRESKFIRNSLSHVKRFGMEDPKQLIGKSDFDFHGEHARVSYEDEQKIMETGIPMINSIQRADLKNGEFKYVSTTKMPLKDVDGNIIGTFGISRDITEMRIAQLKFEEENRLLATLLDNMPDFIYFKDTQGHFLRVSESMAPNFGVKDVSEITGKTDFDFFGDHAKKAFNDEQTIIKTGVPLLNQIEREDKKDGTTTFVSTTKLPLKDQDGKIVGTFGISRDITDLKLAQIKSEEQEVELENLQRMMKSGKDTNKLFKEQKAFFGEVLKHVNDTVLVKTPDGKKYLTSANGTKVSSDDWADEVQIIKDRKPVQRLVKLKTDMGDSYQLDKKAPIYLPEIEDWGILDIQSEIGVNIEDNVKFLEDIRKKYPEILADID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T5</accession>
    <name>A0A654E0T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">MARINOS108_120499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="11380" checksum="80133D4C18BCDFA8" modified="2020-04-22" version="1">MNQKIRIKLKSYDHNLVDKSSEKIVRAVKTTGAVVSGPIPLPTVKEKFTVLRSPHVNKKAREQFQLCTYKRLVDIYSNSAKTVDALMKLELPSGVDVEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E193</accession>
    <name>A0A654E193_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">atpH</name>
        <name evidence="7" type="ORF">MARINOS108_140116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="20577" checksum="3A54D94A4BA32616" modified="2020-04-22" version="1">MSITRIAARYAKPLLELADEKKVTEAVKNDLVNFSDICASNRDFVLMLKSPIITNFKKAEILKQIFDKKVNPLTAAFFDIVTRKNREKYLPEIAREFMVLYNLKMGYQNATVTTTVKLDADMKKAFEKLVTELSGKKPLLSEKVNPELVGGYILQMGDQQIDESLSGHLADLKLKFQKETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C5</accession>
    <name>A0A654E1C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="57" mass="6740" checksum="1D0EACA7A80F206C" modified="2020-04-22" version="1">MSAGVWHIDSKDTRTNNVKMTLFIALAFLVGLGFMNVFIIRLFNPRRNWKWPYLKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H5</accession>
    <name>A0A654E1H5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024830087" evidence="1">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19392" checksum="FA80422966EE59E6" modified="2020-04-22" version="1">MKNKSGKYLILMILMGLTTQPLFAQEDILKTLVEDRTDHKYVFYPSTLRMINLTKNQEYNELVKDVSKLYIYMLDSAIRADKGYRKIAEGYTRLGYDEYAMAYGGDLSLAILGSEQASTNTFVGYLIQDELAVAFYLSGTIAWQKIPTLLNTLRKEDLFNFLDPTSQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H9</accession>
    <name>A0A654E1H9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21784" checksum="0791FDFDECA96D35" modified="2020-04-22" version="1">MFLTFRGPFSQPRFIDFHYYSGLENDMTDMKLKVEVNGRNEFQIAEREGGAFINGEETSYSLHKKSSNEFLLYQNQHVYQISVVESHDSTLTLNINGEEFSVSTKDHIAQILEDLGMDVITNEVINEINAPMPGTIIDIAVSEGQEIQEGDTILILEAMKMENIIKSPVNATIQKIHIGKGQNVEKNQVLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J2</accession>
    <name>A0A654E1J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="441" mass="48580" checksum="1BB0FD43A902F04B" modified="2020-04-22" version="1">MHNIGLIIAREYLSRVKKKSFIVMTLLAPLLFGGFFFFIAWTATKDVDTKTIQVVDKSGMFSEIFIDDSQMEFSYSDKSLDAAKEDVLNGDFDGLLYIPDIDVAAPAGVVFYSPNNPSVSMVHDLSRKLEGEIENIKLRQSGIQKEVLESLKANVDISTINLSGSGDEKESSSIGATVVGYVASFLIYIFIFVYGTQCMRGVVEEKTSRIVEVIIASVKPFELMMGKVIGIAGVGLSQFILWIVLTTTISTAVGGIFANQAMDAQKQQTEQMDAMNLPQDETAQQMEESLLGSISSAVESINMPMVIVAFLFFFLTGYLLYGALFAAIGSAVDSDADAQQFMFPVTMPLILAIVMLSAVLNDPNGSLAFWMSMIPFTSPVVMMMRVPFGVPVWELALSMVLMIGGFVFTIWFASRIYRIGILMHGTKVNYKVLAKWIMMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y3</accession>
    <name>A0A654E1Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="402" mass="46428" checksum="8CCEA942A97893D6" modified="2020-04-22" version="1">MVICGKIQSIGVFISVVVFLPLMTHAQSEVKIYQDADAYMRQEKYDLAVDAFQYISDLPDVKYKSTISALLSKKYRYRSIDTYLEFEAEKGKDPLYYYWLGKIYLRRNILSKASEYLNQFLQMSEGMNKLDSYRQEAQFKLQFVNAAETSMAVTPLESPINSNFAEMSGVLFDDETRLLFASDRLEEGKFDIYVTEKGPYGWNTPNVISQSPVEVDHLNLLYVRGTFMYYNQQSSQLNEMEIGAKDWKVLSAVETLDLAGVQHIYMNKYKTRLIFSKPTEENGLEIFESLKLRSTGEWMEPVLISPQVSSRYNEDYPYLTDDNKRLYFSSDRPGGLGKRDIYYSEFDDVKNVWGPPINAGIPINTVDDDFDFRVSSDNEAVFSSDRIESTGDYDLFVLQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E205</accession>
    <name>A0A654E205_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="32805" checksum="586142F73B327FAF" modified="2020-04-22" version="1">MIERKSRIVMGMDVGGSHVTAALVDLDDHVFLPDSQCRLDLDSQRPADYILEDWQKVIQTCYRQYPDLERHIGMAMPGPCDYDSGVCMIKGLNKYGNLYGLNIPEALSQTLDIPDENVVMTNDAACFLQGEMAMGAARDSQSSIGVILGTGCGTARLQGGIGCDAALWQLPFKNGIAEDYLSTHWFKTRYRELGGADIGGAKDLALSYQDDPISRTVFEEFAQNLGDFLGIFVKMERADSIVLGGNIMKAGNLFLPGVKDRLASLGVNTPIHLSTLGEDAPVVGAAVAYEKKTVNHFNYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E256</accession>
    <name>A0A654E256_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="20081" checksum="2B2736954B4F378F" modified="2020-04-22" version="1">MKKKEKIRSIIVFLLVSTVFFGCEKLDFTQFTMDYTSEFTYSGGLGTAIPFTARTPEISSNSSSTFSANNTRKDKVEEVNLQSMRLEIKTPADVDFDFLNEITISINAEGLSEKVIATKTNIPEEGLTSLEMDVEGSVNLKDYVTSDQFTFKTTTKTDKTISNDITVTIKSVFFVDAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E289</accession>
    <name>A0A654E289_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ComF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="141"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="26176" checksum="5C35BEF566E8F13D" modified="2020-04-22" version="1">MNVVGIIKEYLQDFVSLIFPRICINCSTILVYQEEHICIKCRLSLPKTDYHLQNANPLKSKFVYEPKVLGVVAYLHFNKGGVAQKLVHELKYRGQQEVGIMLGEWYGYDLIKSNWPVDMIIPVPIHKSKLRKRGYNQADCFAEGLSSSMEIPVRTDLVERKKSTMSQTRKSKVERWQNVNEIYRVTNSAELQGKNLLVVDDVLTTGATLGELVVALSEGGAAGIYIATIAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E298</accession>
    <name>A0A654E298_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="34757" checksum="9BB6F73453AD8CC6" modified="2020-04-22" version="1">MLWVNTESCDPWESIKHFRYSEIIIILFRSIFQGTLVIQRRLLDVFPQGILFKGHISEWFHSFGVQFIEFFYPGEDFLHVFDVAIGFVRVDLQTGQMSDFFKRLMVYFHRNTLFKAILANRPDFIGMMCQKFGLDNGKGFCLQSFHFLVITCFRENGFVYNYFAPMMMKPDGGFVGKQQKIVGHGDRDDGNAFFDGQFECAILERNHIREVFFLYKHTSFREETKIETIINSLFGHLQASGTTPHAGPVHGDVHIPEEKPEEGDFSERAFSNEFGRIEQAKSRNVEEREVIATKDVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D1</accession>
    <name>A0A654E2D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="311" mass="36054" checksum="9CE23BB17D2617E0" modified="2020-04-22" version="1">MRQIFEYLKEYQRKHFDLKLYLLISLFLTICFVFNYTYDFEDSVIDSYRGTFLHWLYMFLWMMFPFLGVSLLIARVKQIPVFTGSFWLMLVIGFAILALDRSFIGHLQIIKGLRPIDYRFAARCLNWSSSIFLNVIPLMLVYAIFESERPRNYYGLALKRFDPKPYFLLLAGAMVFIGIGSFFSDIQSYYPRFQYSGGDNFAEAHGIPVWMSVLLYEITYGSDFVSVEVFFRGFLIHAFVKTLGGYAVLPMVASYAFLHFGKPLTEAISSVFGGYILGIISYNSKNVWGGIIIHMGVAWTMELFGYLQSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J3</accession>
    <name>A0A654E2J3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlD</name>
        <name evidence="4" type="ORF">MARINOS108_20130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="32125" checksum="3D9739A02EE38294" modified="2020-04-22" version="1">MKILVTGSGGQLGSEIQDLVSEFPELQFDFTDYPELDITNASLVSDLFKQNKYDYCINCAAYTAVDKAETEREASDKINLTGSLNLAKACKPYDVTLIHISTDFVFNGGASVPLKESHLTDPVNYYGVSKLKGERAIQNTLKKHFIFRTSWLYSTHGENFVKTMLRLSQTRDELNVIADQIGTPTYARDLARAILLIISAKSTSYGLYHYSNEGVASWYDFTKAIFEYRKVNTRVNPIPTEKYPTPAKRPHYSVMDKSRFRETFEIEIPYWRESLKACLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K4</accession>
    <name>A0A654E2K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase-3 subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="374" mass="42199" checksum="D0A792EE6B5E55E9" modified="2020-04-22" version="1">MRFADIPGLESLKESLVASYKNNHIAHAQLFNGPVGGGGLSMALAFASYLLCENKQEQDACGACPNCHKMERLIHPDVHYIYPKPSASKATEYDKLQSDTLKKWRTFAHEQPYGDIEDWVTYNGYENKNVLISKEDSRNIIKTVSMKSFEGDFKILIIWYPEYMHPAAANGILKVLEEPPTQTIYLLVSYAYDTLLATIKSRTQIFNVAPFQESVIAEHLISQRGADPQVAEKIARLASGSMGKAFYELEHAGSIAYESFRNWMQICLKGDYTAMVQNTESFLQSSKPQQRNQLEFAIALIRDAILSKADNDQLLQREGAEGEFIKKFGGFATLEVLENIYINISNSLNHLQRNASPRITYMNLSLQCSKLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K5</accession>
    <name>A0A654E2K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="65" mass="7655" checksum="36FCD3A8E1FEBC8A" modified="2020-04-22" version="1">MGFACFITILAWLMVATPSYFWKGFFIGLLFLVLLILIADTYNSKRNDEYLESLKTYFERSKCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M5</accession>
    <name>A0A654E2M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="1">MECDP-synthase</shortName>
            <shortName evidence="1">MECPP-synthase</shortName>
            <shortName evidence="1">MECPS</shortName>
            <ecNumber evidence="1 2">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">ispF</name>
        <name evidence="4" type="ORF">MARINOS108_20333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="1 2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="17830" checksum="503B4969E6FEE23E" modified="2020-04-22" version="1">MKPNIRIGYGYDVHAMAEGIDFWIGGIKVPHTHGAYGHSDADVLIHVICDALLGAANMRDIGFHFSDKDPQYKGIDSKILLKKVVDLLDEAGYGIVNVDTTVCLQQPKLSPYIEPMKACLAEVMGLPVEDVSVKATTTEKLGFVGKEEGVAAHAVVLIYKKSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T3</accession>
    <name>A0A654E2T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capsule biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024929787" evidence="2">
        <location>
            <begin position="20"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="502"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="600"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="723"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="827" mass="91607" checksum="A403AC2638E9CDAA" modified="2020-04-22" version="1">MSKVIIRIFLVCIITVAHVAITKAQDASSIQNLQNVNVDELSDEQVQKFIDQMEASGYSEQQLEVLARARGMSSTQLSKLRQRIAKLQSGSSGGGSKEISRGRTSTIDYNRQANDENRSSTFDPFASIFPLDTLKDDSELKIFGLSFFKNQNLTFEPSLSIATPKGYQIGPGDQIIIDVWGASEQTYQLEVSPEGSIIIPSLGPIYLNGLSMERAESRILSKLKAIYSTLGDNTHAQVSLGQTRTINVNVIGEVDRPGTYQMSSFGTAFNALYFAGGPNNKGSLRDIQVFRGGQKVATLDAYSFLIYGEGQNIMLQDQDVLLVKPYLNRISIDGEVKRPAIYEIKAEESLSKLLEFSGGFTAMAYQASISLRRNLGNRKTVQTISPEDFAGFKLQGGDYIEIGAIQDQFIGRVRIEGAVNHPGEFELKEGMMLSDLIAVSDGFRADVFLPRAIVIRQNDDLTLSNLAFSPQEVLNGTFDLALKSEDLIRVQSLFDMKENYTVSIQGEVLIPGNYPFAKGMTVENLIYLANGFKETAAKSFVEVARRVTEDMGDGSNASEIFNFPIDQNLSLNATGSQFELKPFDLVVIRKSPFYEKQSIIEIEGEVQYPGKYALQTKNERISDVLKRAGGLTAFAYAKGATLIRRTEYYVSDDEGDEAAKIRREELKGLLARDTLVDKSQQAFKAQESIGIRLVEILENPGSGFDLILKEGDVISIPRELQTVRIRGEVLYPSTVRFDKSNSFNQFISKAGGFADNAKRNKSYVVYANGSAERTRSFLWFKDYPKVEPGAEIIIPRKPERRKLSPGEIISITTGIGTLALIINNLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X4</accession>
    <name>A0A654E2X4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_20602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="355"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD19168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="433" mass="47668" checksum="A26CB501A931DA6A" modified="2020-04-22" version="1">MPTGRKHSTLTREQIRNYLEGKLTGKNAHAVERQLLNDPFDEEAMEGYALFDPELTETDLDGLMKRVAARSKKRQSYAWRWAATFALLAVAAVVVWLVVPSLDPASDQLSLKEEDKQEKDAADMGDSKIVQEEVVIPEPPFIKEESVPVAEATRPKPEENILTEENEEGPSQEDVAITTRRPEPSADELMEEDQVIELADETLAEVVMEEVIPEESSALKKEAVAMSRSTGAVTRSALGVDNMVTGTVTDEAGTPLPGVTVVVKGTAYGVMSDSNGQYNLELADRSAVLVFSYVGYDQIELKVGDRRQLNVELETDVQALSEVVVTTYAETNEMSFESAEPAEGLKAYRSYLERELNYPRTAIDSNVSGKVILKVAILATGEIGTIEVKRSLGFGCDEEAMRLVRTGPPWRAATRNGEPVESQVRVKVVFQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E396</accession>
    <name>A0A654E396_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gliding motility-associated lipoprotein GldH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020018">
        <property type="entry name" value="Motility-assoc_lipoprot_GldH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14109">
        <property type="entry name" value="GldH_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03511">
        <property type="entry name" value="GldH_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="18088" checksum="F437EE705214E3AD" modified="2020-04-22" version="1">MIKSIWLLIPVALLLACDPDRVFEENKNLEEAYWHKDSLVTFEFDVPAADRKYDLYANIRNAQHFPFYNLYYQYTLSDSSGVVLAQELKNINLFDPKTGEPYGSGLGDLFDHRQLLLSAYDFPAQGKYTLTFEQYMRQDSLALIMSVGARLEQVTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B5</accession>
    <name>A0A654E3B5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="168" mass="19509" checksum="9A862D092BF0B1A2" modified="2020-04-22" version="1">MKKILDLNDLMVEQLRELYDAEIQLVPFLEKMRLLATNHLLVKLITKYQRTTDDNHWVLKQVFNDLFMQKRGEKNAAVRLMEDQTLEILERCATPEVKDAAIIISLQHIMHFKIASYGAVATYANIMGLYGDASKLHMLVELEKKIDRQLAMLADGEVDRKAFNYQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H1</accession>
    <name>A0A654E3H1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 16" type="primary">secA</name>
        <name evidence="16" type="ORF">MARINOS108_20819</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="15">
        <location>
            <begin position="6"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="182"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="622"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD19701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1116" mass="127007" checksum="1EB643F1F58BED9A" modified="2020-04-22" version="1">MLDLVTKGLTKVFGTKADKDIKAVTPYVEKINKEFEQLRDISDDALRGRTAELKSIIAEKLKHVDDELKSLHDKVESDPQLDILEKEQIFEQIDNLESKRDEELEDILLEILPQAFGVVKETARRLTENKQLVVTATMMDKELAANKEHIKIDGDKAIWANKWKAAGTDVEWNMIHYNVQLIGGIVLHQGKVAEMATGEGKTLVATLPAYLNALAGRGVHVVTVNDYLAKRDAEWNAPLFQFHGLKIDCIDRHQPNSPERRQAYQADIIYGTNNEFGFDYLRDNMARSPEELVQGKHHFAMVDEVDSVLIDEARTPLIISGPIPKGDEHEFYELKPRINKLVEAQKKLVSEYFNQAKKLIKEGKESEGGLPLFRAYRGLPKYKPLIKFLSETGIRAILQKTENFYLQDNQKMMPEADEPLYFTIDEKHNSIDLTENGIDLITGSGEDPTFFILPDIGDEVAKLENDTELDESEKLKRKEVVIQDYSIKAQRIHSINQLLRAYCLYEKDTEYIVVDGKVKIVDEQTGRVMDGRRYSDGLHMAIEAKENVKVEDATQTYATITLQNYFRMYHKLAGMTGTAETEAGELWDIYKLDVIVIPTNRPIVRDDRNDKVYKSIREKFNAVVDEIVELRGMGRPILVGTTSVEISEVLSRMLKIKNIDHQVLNAKQHAREADIVAEAGKPGTVTIATNMAGRGTDIKLTPEAKAAGGLAIIGTERHESRRVDRQLRGRAGRQGDPGSSQFYVSLEDNLMRLFMSDRVAKIMDRLGLQEGEVIQHSMITKSIERAQKKVEENNFATRKRLLEYDDVMNSQREVIYKRRKNALYGERLELDINNMLFDTCEDIALNAKADNNLDGLKLNAISVLGLDFHITQEELTKYMEHELTDKLYTAAKEHYKNKNAFTASRAFPLLKQIHKEKGATVQNILVPFSDGKKQIGVTAHLEKSVETEGVEMIRAMEKMITLAIIDQTWKEHLREMDDLKQSVQNAVYEQKDPLIIYKFEGFELFKSFLGKVNEECTSFLMKAQIPIQDPNQVQEARDQRATRNYKESKEESGSLLNRGQANRPPAEKVEPAKSVKIAGRNDRVTVQYGDGSVKKDVKYKTVEEDLKNNKCILIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H9</accession>
    <name>A0A654E3H9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucA</name>
        <name evidence="6" type="ORF">MARINOS108_20829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="5">
        <location>
            <begin position="571"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="904" mass="103788" checksum="0F571D359626B0AC" modified="2020-04-22" version="1">MDKYSYISNADVGYIDELYKSYKENPENVDESWRKFFEGFEFSQQRYGDGGPSEEIIAGSKEIKVRNFIYAHRSRAHLKSDTNPVRQRRTHNVRLELSNFDLSEADLNETFEVGSEIGLPNATLNEIRDRLARIYLGHIGYEYNHLRNSDIFDWMKTKVETEGVDVNPSDEEKTRILSKLNEAVVFENFLHTKFLGQKRFSLEGGENTIPALDKIIRRSSELGAEEVVIGMAHRGRLNVLANIMGKTYEEIFAEFEGSTDPDLTMGDGDVKYHLGYSSHLQANGKKIYVKLAPNPSHLEAVDPVVLGYSRAQIDDEYRGDMKKVVPILIHGDAAIAGQGLVYECIQMSLLDGYRSGGTIHFVINNQVGFTTDYDDARSSIYCTDLAKIIDAPVVHVNGDDPEAVNFAANLAVEYRQKFNKDFFIDLLCYRRHGHNESDEPKFTQPKLYNLIAKHPNPREVYVKQLIERKDISPDRAETLDKEFKQQLQDRLDEVKQKPLPYKPQKIEEEWHFLRRSKPEDFDKSPETGISDEVLKKVSKALTTIPKGFKPLRQIDKLLKERKSHFFEEKMLNWADAELLAYGSLLAEGNIVRMSGQDVKRGTFSHRHSYLFDSNTNEPYCNLDHIQEKQEPFRIFNSLLSEYAVLGFEYGYAMATPNALVIWEAQFGDFSNGAQVMIDQFITSAETKWQRMNGLVMLLPHGYEGQGPEHSSARMERFLQMTAQENMIVADVTTPANLFHLVRRQLTWEFRKPCVVFSPKSLLRHPKVVSPLEEFTKGNFQEVIGDDYVTNKSVKKVLLCTGKVYFDLQEEQQKKKVKDVAIVRLEQLYPFPKKQLEAVLKKYNNPQLVWVQEEPENMGAWGFMLRISGLTLKLVARKPMASPATGYSKVHKREQAEIVNKAFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J4</accession>
    <name>A0A654E3J4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="977" mass="112321" checksum="AB453C17128457CA" modified="2020-04-22" version="1">MLNVHSYFSFKYGLLSIDKLMEWAMRNHVRTLALTDINSTAGSLEFVRQAQKQGIRPLLGVDFRNGAEQQFVAIARNNAGFQSINTFLSKHLHTGAPIPAFTDELQDCFVIYPQTNIPTRELQPYEYLAIKPREVTRIRFLSKLPREKLIACPVYTLPEEGDFELHCVLRAIDLNTLVSKLADTDTAHKEDVFLTKKQLTDYYQELPEAFENLKTVIQSSCIDFTLGAEATSQNLKTWTGSQDSDYQKVRELSLAGLSYRYGDSPSFTIRRRVITELRVIRQMGYLSYFLISWDIVKYARDQGYFYVGRGSGANSVVAYLLRITDVDPIELDLYFERFINLFRKSPPDFDMDFSSWDREDVTRYIFERYENVVLLATHSTFQWRAVIREVGKVFGVPPYEIERLQKTPEQNLDHHARLILTYGDRLSGFPSHLSVHAGGIIISERPIHYYTATSLPPKGFPLTHFDMHIAEDVGLYKFDVLGQRGLGKIKDALEIIRENQPDRLPIDIHDIKLFKEDELVKINLREAKAIGCFYVESPAMRMLLTKLRAEDYLTLVAASSIIRPGVAKSGMMREYILRFRIPERRKEAHPVLWKIMPDTYGIMVYQEDVIKVAHYFAGLTLAEADVLRRGMSGKYRSREEFQQVRDKFFANCEARGYEPAVSADVWRQIESFAGYAFAKGHSASYAIESYQSMFLKSHYPLEFMVAVINNGGGFYSRELYIHEARMHGADIQLPCINTSENETIIRGKTIYLGLNFIKELEYHKVHEVLMDRQKKGAFLSVDDFVKRVSISLDQLSLLIRIGAFRFTGKDKKALLWHAYFLLGNTGKSQNKPSLFDPPVKKYKLPEIEHEAIEDVYDEVELLGFPLESPFNLLSEKRNDCVPASKLPLHINKVVLVMGYLVATKHTSTSKGDRMYFGTFLDEDGEFIDTVHFPPVAKKFSFTGKGIYLMRGKVMEEFDAISLEVNAMKRLKYMTMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K2</accession>
    <name>A0A654E3K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="104" mass="11458" checksum="82707744C80CE5A2" modified="2020-04-22" version="1">MCKFAVLFDKVMSPIQAFVIGSVGGFIGYLLILKRNFSLIGKAGKKSKKEMVLSHYLLFGLLVSVLSGGFYTMWVIGPIDEKQAFLSGLTAEGFLIGYIKTRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K5</accession>
    <name>A0A654E3K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DgsA anti-repressor MtfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010384">
        <property type="entry name" value="MtfA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042252">
        <property type="entry name" value="MtfA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30164">
        <property type="entry name" value="PTHR30164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06167">
        <property type="entry name" value="Peptidase_M90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="263" mass="30140" checksum="866F76348DEB228C" modified="2020-04-22" version="1">MISGIVIALGGLFGLGVYYLLFGKLLSEGTLARLRISASLSPAQKDRLSRHFKFYQLLPPKSKALFEYRVAKFIRMKEFVPRNMTHVTEEMQVLIAASAIQLTFGYPKVFLSYFRYVIVFPDQFFSNAGQRYHKGEVNPKAKAIVLSWKHFVEGYSKSDGVNLGLHEMAHALQLENIVMNDEYDFLDSEAIKHWQTLASAEITKMQHDTTSFFREYGASNHAEFFAVAVENFFERPVAFHDYHPALYLALARLLKQDPMLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X6</accession>
    <name>A0A654E3X6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">MARINOS108_20982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="596" mass="66964" checksum="D8420CBA3BA44732" modified="2020-04-22" version="1">MKHIRNFCIIAHIDHGKSTLADRLIQSTETVSARDMQAQLLDDMDLERERGITIKSHAIQMYFPYEGNQYTLNLIDTPGHVDFSYEVSRSIAACEGALLVVDAAQGIEAQTISNLYLALENDLEVIPVLNKIDLPGAMVEEVSDQIIDLIGCDREDIIHASAKEGIGIQEILQAIVERIPAPTGDTEEPLQAMIFDSVFNTYRGIEVFFRVFNGTLNKGDHVKFVNTGKTYEADEIGVLRLTHEAKNSISAGNVGYLISGIKVAKEVKVGDTITHVSRPTQRTVKGFEDVKPMVFAGIYPVDTTEFEELRASMEKLQLNDASLVWEPETSMALGFGFRCGFLGMLHMEIVQERLEREFDMTVITTVPSVQFHAIMPDGAVLKVNAPSELPEPNYVSHVEEPYIRAQIITKSEFIGSVIGLCMDKRGEIKNQVYLTSDRVELTFELPLAEIVFDFFDRLKTISRGYASLDYELIGYRQSNMVKLDIMLNGEKVDALSAIVHRDKAYEWGKRLCEKLKELIPRQMFEIAVQASIGTKIIARESVKAMRKNVLAKCYGGDISRKRKLLEKQKKGKKRMRQVGNVEIPQEAFMAVLKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z5</accession>
    <name>A0A654E3Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="449" mass="50310" checksum="AD49CDC659A8F8BB" modified="2020-04-22" version="1">MNLLDKLTYWITSGLAIVLVPFFFACDDPSRLGLELESEDNPIVTQKMEFVLPASTIYIDSLRTDQFTHSIFGQYEDSIAGKATVVSYNQYNIYGGVLPGGDSLEYVSTILSIKVAGQRAQRGLAGEQIIIHEVNDTLYNQPVYLADRKLDHRPETIADYTFDYNPLTDSIIQIPLTDTFGQFLYKRLEKATLGGVNQDSLLLGMYHYPPLALIPGAGNKGLFSFDLKDDTTRIYVNMKNAAGKLYHFSFDFSDAHYSQIDRDRSSGKFSDIVSEYEESNAITGRTHLDMVNGIHTKLDLSPYLDFVKSHEDFIINRATISMEVVPQDEFSYIETVPFIRNYFIKSNGKINGSGVSRGDGFNNAILTEADYASSGNSTNILTMAYNKDNSEYLANVTLFTQVLADDYTLSDEFLTEHLVITSPETISLGQTSFNKSGMKLTIFYTTLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E404</accession>
    <name>A0A654E404_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="8"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="110"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="36032" checksum="AFE44FC773CFFBAC" modified="2020-04-22" version="1">MNEEGLKVLIVDDMHESITSLFENAGFVPDYRPLIRPEEVREIIHEYHGLVIRSKMSVDRELIDRAVNLKFVARAGAGLDKVDYTYVSSKGIKLINAPEGNRDALAEHTVGMLLTIFNKLNTGTEEVKSGVWNREANRGWELMGRTVGVYGYGYMGAAFAQRLKGFSCRVVAYDKYKSGFSTDYLEEVSLQEFFDEVEVLSIHVPLTSETRFLFDEKYFARFKNLKFLLNTSRGEVVKLSAVNDLLKRGVLLGAGLDVLENEKLDKLTEAQRADFEELISYPNVILTPHVAGWTFESYRKINEVLIRKLQAGDLAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E476</accession>
    <name>A0A654E476_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="392" mass="44307" checksum="55650480A21368EC" modified="2020-04-22" version="1">MNKSGTHKKILISISTLEVGGAQTFALKLASILSENSQTEVYFFVWNGDKVETQMLNTLLSKKVRYYDLNRFHLINYLGWKLNALEESSGKSPSIRQKMIGLLFKYIIWKHRVDVVHSFLYPSDLNCAKHLHSSVPLVVTEEGDYLLRMRKGEEIDEIVIGRVNSWVAVSEFAKRKLASYLALDPKRIKLIYNGLPFVPVKNEEQKDKDSFVVGMVARGHQSKGWEALILAFLGAKKRVQRQMKLVLVGEGTFLDQLAKTYGDQEGIVFTGYSSNPGLYIAGFDIGVLPSFFEGETFGISVLEYLSNGKPVIVTDWGGLPEVMQDGEHYAGYVVGFHDDGKPNIGEIEDAIVKMASDPEVYADLRRNIDKVISRFDWKLISAEYQETYQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B9</accession>
    <name>A0A654E4B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A phosphate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_50083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="28915" checksum="C146D56FF3993C61" modified="2020-04-22" version="1">MLRQGQFLFKYRGLLPVAFLIIGLIIFFLQARHSAFFFTEDDQRTYDLACLCLALSGLIIRIITVGYSPKGTSGRNTATQVAHQLNTTGLYAVTRNPLYLGNFLLWLAVVLLCQHLGFTILFLLSFWWFYRLIIFTEETFLETEFGADYLTWKHNTSVFFPSLRKYQPSTRAFNWKKVLRKEKNGIAAIFGIFFLFQLSGAIAAPEKFHPVTFLADHLFWSVCALGSGLYYLLIKVISATTNWLENNSGTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L5</accession>
    <name>A0A654E4L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-hydroxycarotenoid 3,4-desaturase</fullName>
            <ecNumber evidence="5">1.3.99.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtD</name>
        <name evidence="5" type="ORF">MARINOS108_60135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.27" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="487" mass="54552" checksum="42E6B08148C88880" modified="2020-04-22" version="1">MSYKVGIIGSGVAGLASAIRLAIAGHRVEVFEANAYPGGKLSEIKLGAYRFDAGPSLLTLPSLIDELFELAGENPAQYFTYQKLEINCEYFFPDGVNISAHADHEKLIEEIIQNTAERPENVRKALAKSQLLYEHLSELFMFSSLQDPKTFVSRPAFKAYRKLHRLGFFQTMNGANASTFDDPRITQMFNRYATYNGSSPYKTPATMNIIPHLEMSLGAYFPAGGMHSITLALYDLAKRLGVIFHFNQPVERILIEKGHAKGLMTGGLSLDFDRLVSNMDIVNSYRKLMPDLKAPRFLLNQPKSSSALIFYWGVGKKFPQLDLHNILFSRDYKAEFEHIFQRGVIFHDPTVYINITSRYEPSDAPEHGENWFTMINVPNNQGQNWEELITEARKNILNKITATLGEDIAPLIEVEEILDPRTIESKTSSALGALYGNSSNNLFAAFLRHANKSRRVKGLYFCGGSVHPGGGIPMSLSSAKLVAKYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q5</accession>
    <name>A0A654E4Q5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpd</name>
        <name evidence="16" type="ORF">MARINOS108_20831</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="3"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="345"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="465" mass="50642" checksum="AA8A53D2227CD625" modified="2020-04-22" version="1">MQYDVTVIGSGPGGYVAAIRAAQLGFKTAIIEKYPTLGGTCLNVGCIPSKALLDSSEHFHNAETTFKEHGIDISQPKVNLKQMIARKADVVKQNVEGISYLMNKNKIDVYEGVGSFKDKHTILIKSQKEEKEITSDKIIIATGSKPSSLPFIKLDKKRVITSTEALELKEVPKHMIIIGGGVIGMELGSVYARLGAKISVVEFLDNLIPSMDGTMGKELQKSLKKLGFDIYLSHKVTAVAAKGKEVTITAENSKGENLELKGDYCLVSIGRRPYTDGLNLENAGVKMTDRGQIEVDEHLKTNVDNIWAIGDVVKGAMLAHKAEEEGVFVAEQMAGQKPHINYNLIPGVVYTWPEVASVGYTEEQLKDQGRKYKTGKFPYKALGRARASMDLDGLVKVLADKETDEILGIHIIGARAADMIAAGVTAMEFRASAEDVARMSHAHPTYMEAVKEACLAATDNRPIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R2</accession>
    <name>A0A654E4R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_3" evidence="2">
        <location>
            <begin position="453"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="924" mass="102040" checksum="B5F65B6773D06121" modified="2020-04-22" version="1">MKKLLMAFFCFGTVMVTGQGLKVAGRVLSEGDGEPVMAATAAIASIKDSTVQHFDLTDADGYFQLSGISPAFYKLEVRSVGYQAYEKIIRIQGSLELGVIKLAYDTMELDAVEVRGQTVGVIISGDTTAYLSNAYKTNPDASAEDLIRKMPGMIVDGDGVQAEGESVKRILVDGKVFFGDDPSIALKTIPAQVIDRIEVFDQLSEQSRFTGFNDGNTTKTINIITKREFQNGQFGKAYIGAGPDEKYNGGGNVNFFNADQRITLVGLSNNINVQNFSSEDLVGVSSGAERGRPGGGRPPGRGVGSGSSSSDFLTGQQSGISQTESFGVNFTDDVGERLKLNTSYFYNSSDNSNDQLTHQEYFLSSAEDQRYEETYNFDSENDNHRINLRMDYSLNDKTSILFTPRISFQQNLSETDLQGMFDAADGSRLSTTQTQSTTESGAYNLSNDLLIRHRMNTPGRTISLGLRSTVNHVQQETLLNALTSYTSKEGTSDTTNQRTDAEVNTATYSANLRFTERVGDASMLELGYAAGITYNDSNKETFGLDVEQNAQLDTTLSSVFESQYQTHQWSTGYMYRKSSMMLRASLAYEYALLSGQSTFPTSEDLGRSFQNVLPSVMLRYEFDDSKNIRLFYRTNTQEPSVTDLQDVVDNSNPLSLESGNSNLRQSYSHTLMSRYGAANSQRGTSFFAMVSTTQTNHYITSSTFTAAQDTTLENGIRLLSGGQFTQPVNMNGYLNSKVFTTYGLPLSFLSSGLNFNTTFSYTLTPGQVNGQVNKSRSTGLGQGLVLSSNISEKVDFTLSYDGSYYIVKNTFQPQLNNNYYYQVASARLNLILPAQIVFRTDFSHQLYAGLSDSYNQQYALWNASIGKKIFLEDRGEIGVSIFDLLGQNTSISREVTETYVQDTQTEVLGTYFMVNFSYNFRNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E539</accession>
    <name>A0A654E539_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="362" mass="41349" checksum="12D65D6C58D29AA4" modified="2020-04-22" version="1">MIINSRGLALMLAFVISMIATAFLALVPSVLTTALIIGFGITFCASYILIRLVLEFLFFRHINDINEALENFQDQELSNITKPTKTLSLNPLKRINKDIFSYAEKKQQEILELKRMEVFRREFIADVSHELKTPIFAAQGFVHTLLDGAVEDKKVRGKFLKKAAKSLDGLDILVQDLLTISQMETGEIKMHVENFDIVALAREVLDQLEDKAEKQKIDIQIEEPTARHFVKGDYRRIYQVLINLMSNAIKYTKKKGTVRIRFEEKDNHVITSVVDNGRGIPQEDLKRIFERFYRVEKSRSKEKGGTGLGLAIVKHIMEGHGSTVEVKSQVKKGSTFSFKLKKGKPVAHRFVEEDEEDEEDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E575</accession>
    <name>A0A654E575_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UDP-N-acetylglucosamine 4,6-dehydratase (Inverting)</fullName>
            <ecNumber evidence="3">4.2.1.115</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.115" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="35106" checksum="50F5F110DFAFBD71" modified="2020-04-22" version="1">MENHLRKKVLITGGAGYLGSFLVGELLKQEDTHVVVFSRDELKHFNLKMQLGDLSQRVDFVIGDVRDEDRLAEACNGVELVIHAAAMKQVGTCEDNPTECYKTNVLGTENVIHAARRSGVRQLIFVSTDKAVEPVSVYGNSKQAGERLVLKSNSPEFQASVIRFGNLIGSPGSIVDKLSKLNAGETITLYSQELTRFVDSLDNARQLIYAQMSRDFGGVIMIPKLRSVKVADLVSVCAPLIQVKFGGERGFEKIHEKLATKNELSRMCETEDFYLITQEALGQDGALDKFGALPVRLLAYDSETAEAFSTFEKLRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E597</accession>
    <name>A0A654E597_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C4-dicarboxylate-specific signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="803"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="746"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117506" checksum="F0748F187862D23B" modified="2020-04-22" version="1">MIWSRVLPLRKSLFLLCCWIGSHVVNGQYFSACVYKNLDGMVSNRITEMEQLPNGEIWFATQDGISTYDGTGWLSFPDSLGILPIIGKVCLEALSDSSVYVLGFNGDKLSFSVYTDDRWSPLNLPPEIANLPLHSRYVMGHHLSGHGNSLIIGTQNKLYFYSDNQWNLDLLGQKDPESFKINSIKTLGDTVLIASSQGLHIYLNGSLTTLVEHEEVLDLDYNEEDDTFYLLGKDWLGVLSSGSEEITFLFRNELIGYPDVGAVSNLMHHRGKLYYSSNSPLHQYDLHSHEKRAVITEYFDLDYVCMNAMVDHEGSLWVATLRGAFKVNNQDTWNFNSHFLLENEVSAILEDQNGDLYFGSNLGLNIVRSTGDIEKYPFPRKFIHARVMDMVSFEGNIYMAGNTAGVVRFKDGQFDFDLINENSRVLDLQVHQGRLYASCQNTIYRKDGNLWSPITTPQKDDYGIIRKMAFDDQRQLLLTQMGVSDLVSGEFIQSEILNDNNIYTGIQYDGQFLLGTANGVRVLEGNQIVHSPIYDHFDSPVYSFLADREGRLWVGTGKGIYLVSPNETYHLSKTNGLAGNEVNRNALVLSRNGKILVGTDEGISIYDPRAIPELPVPKIEYLGATVNGTPTSSQSFDHSENNIRFQYRSVSFYDEEHINYRLKLDGLEDQWQHIPFYNQHTILYSNLKPGTYQFMVQARIGNGGWSPTATSPVLTVKSAFYDNSWFRVGVLILVILLTLFLARLRSRTLKSRNELLQARVQEKTRELKNQNSRLMKTIKELKSAQGQLIQSEKLASMGHLTAGIAHELNNPLNYIRGGAECIMKNLEELKHLQLQLHAKESEPALLAEYQMLMDDSNQLAQSILNGASKSTDIVKSLSSFTADSQNFYSFTDLQKEVDTSLTLLNNQIGFRITINKMFGNIPPIECYPAKINQLLVNLLMNAVQAIEHEGEITIRYYRKDDKRIGLEISDDGVGIPQDLQEQVFEPFFTTKDTNPGLGLAIVKSIVQEHHGSIKLDSKPGKGTKVRIFLPVNQTAHPELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E676</accession>
    <name>A0A654E676_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8695" checksum="9B84FD91F0F0B78D" modified="2020-04-22" version="1">MYFFDYLGAFYFWVWLNIWNSVNETKRPTFKEVLEGKNRYQKGDIVDQSAYGLKLKFIGVVITMIIVSILTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6R7</accession>
    <name>A0A654E6R7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024927005" description="NodB homology domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="85"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="39331" checksum="4F8B5E35248D6A8E" modified="2020-04-22" version="1">MTALSGPIMLMLSLLFSNPTSSVATNHKEVVCFVYHRFGDNRYPSTNISLADFEAHLQYLRDHGYQVLTFADAIDYLQSNQENRKTAVITIDDGYKSFYANGLPLLEKYGYPATVFINTETVGGGDYMSWFELKDAGNRKIEIGNHTHSHAYFLNLPENSRYKTFDDEIRQSQKIIKEQLGLTPTTFAYPYGELDPKMEAIIRNEGFKAAAAQNSGVISAQSNLMRCPRFPMSESYAALDKFSSKARMHALVTKEEAPTSFMMPEHRRPELTLRFVTGALQIKQLQCFIQGGECQMTITEKEGETSLKLTSAGKLTRRRTLYTVTVPDKNGQWYWYSHLWIDPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E798</accession>
    <name>A0A654E798_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="32821" checksum="CBECC70FCC96F7B0" modified="2020-04-22" version="1">MTISKRSFLIHISLLGSLWSFGQGFSDNDYQFLLHLEFISAYDEGVFWLEQKELVLGRTDTTAFHLGMFEYFRKNRASSIRFFEDVTRSNLNFWNISRFYSGLQYAYLGDYAKANQVLMQTDSLSELHAELRKLSLAGLSLLDHNFERFESFQTSFDPNYYQLVDHQQALLDTYHVMRDRKAKSPVIAGVLSAIIPGGGKFYLGKIGQGTMSLMTSTIFALQAYEGYRKDGPKSASFIVFGSIFSIFYVANIWGSVVAVKVENVNFNKTNHDAILLHMHIPIRLLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7N2</accession>
    <name>A0A654E7N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025071213" evidence="1">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="528" mass="60277" checksum="D77B46398034BCB2" modified="2020-04-22" version="1">MRVNLSYICLVAILLVSINACKEQNDNQGLYSQEYAISKVDLKDKIRGGWAGQTIGVTFGGPTEFRFKGTMIQDYQNIVWHDHYIKETYELDPGLYDDVYLDLTFVNILEKVGLNAPTDSFAVEFANEDYKLWHANQAARYNILNGIMPPASGHWMNNPHADDIDFQIEADFAGMMAPGMTNTASDFCDRIGHIMNYGDGWYGGVFISAMYTLAYTSDDLDFVVSEALKTIPSQSMFYKTIADVIKWHKQYPNDWKETWFEVEKYHSSDKGCPEGVYNSFNIDARLNAAYVVIGLLYGQKDFFETMDISTRCGQDSDCNPATAAGILGVMMGYKNIPDYWKPALEEVEDLKFPYMEITLNEVYDLTFKHTLQLVEENEGKVDDDSVFIKVQQPETVPLEQSFEGMYPSEERYLRQHFTDKNINIDFTGNGIVVLGNVNSLCARSSSDYVALLDIYIDGEKVDQVKMPYDYIVRKYDIYHKYLLENGPHHVEIVWVNKDADYSIYMKSIVIYADAPAKPFNSKKVALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E925</accession>
    <name>A0A654E925_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIRAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIRAN" evidence="3">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12729" checksum="7433D4E9A842D267" modified="2020-04-22" version="1">MAKIIKIPSAFVYESKVVGVSHANADGTSRQEIIRREVAEDDPLFLELEPENEFDPNAVKVLSRERNQIGYLKTELAEQVRSALINQTTIYTRALWVNGEKMLGVGIRIELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9L6</accession>
    <name>A0A654E9L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="275" mass="30710" checksum="6B579671581A8F9B" modified="2020-04-22" version="1">MDSETEYFLSQDGLRLYYRHWDCEHPSKMLCIIHGLGEHSNRHQELATFLNSQGITVFAMDLRGHGLSHGKRGHARSYPLLLSDIEELLKTARAEYTELPMYLLGQSMGGNLVANYVLKMNTTELSGFVLTSPWFRLAFEPPKWKVTLGKLVSGILPALTQPNDLNAADLSRDPVVIEAYDHDPLVHRVISAGLFTSATAAGEEALQRASEVKIKGLVIHGNADPIVSWKASKTYAETNELLTWTELDGVLHEPFQDLGKEEVMQQVAKWILAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA76</accession>
    <name>A0A654EA76_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="51"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="285" mass="31836" checksum="81941587F75EAF9E" modified="2020-04-22" version="1">MDSQEKLYSPISGYTILALCLIVLFSSILLLIGLRIPHFVFGVVLGIAFIPGFFFVNPNGSRVLVLFGKYVGTVKENGFFWVNPFYTRKKISLRARNFDSERVKVNDNIGNPIMISVILVWRVRDTFAAAFEVDDYENFVRVQTDAAVRKLAGSYPYDNFDDEQAEITLRSGLDSVNEHLEKEIEERLSIAGIEILEARIGYLAYAEEIAGAMLRRQQATAIVAARHKIVEGAVSMVEMAIAEIGKKEIVDLDDERKAAMVSNLMVVLCADKDITPVVNSGTLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDT6</accession>
    <name>A0A654EDT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="24398" checksum="4A19E4CF0F551CE3" modified="2020-04-22" version="1">MNDKNVIELFEIFKEYFPKFKSASNYVEEHDRITPQQAFIEGRDILSHIYDISISLDNDEKLKENIIEIKEHFRRGVAESYQEHYEYIAADVYQDYSTYKKRLRPFEKLLRLYKIHKPIHEEVRGRIKQSQDLWIKGRSLKTKDLNSDKFDESINLFIQANDTIEPLSELVNELWNNFYQRSTYVGLTLVALIITSVFLLNYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSP9</accession>
    <name>A0A654DSP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="28" mass="3284" checksum="3AF0259356A02AAC" modified="2020-04-22" version="1">MGYFRVLADADYLKFFEDRPAFARIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT81</accession>
    <name>A0A654DT81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4392" checksum="20DB885F980F8C80" modified="2020-04-22" version="1">MLLSIAPESSWQAVKSRAKNKADKTLTKNDNFFMILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTN7</accession>
    <name>A0A654DTN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="102" mass="12139" checksum="323BB50F7DC4E083" modified="2020-04-22" version="1">MKVAFKTKELEQLYITPLNEIRGKQKFSRDVIKQYQAKVRILTIIDNLKDLYPIRSLNFEALSGNRKGQFSIRLNKQFRLIIIEAEDELIEIEIIEISKHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTU4</accession>
    <name>A0A654DTU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AlpA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="99" mass="11740" checksum="0BB4CC2A1C0F1F16" modified="2020-04-22" version="1">MDEILERLKIIEKHVLDQNLILKNVLNFNEACQYLELSQSHLYKLTSAGSIPYYKPNGKKLYFNRAELDQWLLRNRNSTQDEIDQRAADYLIKKGRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTV2</accession>
    <name>A0A654DTV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="202"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="37715" checksum="973BF4726C915160" modified="2020-04-22" version="1">MARIKYYYDTESCRYERIRVSSWDILWNSLGFLMLAMLLAGGIVFIYTKYFESPEEALLRKENEELRMYYELLSKEVTDANQMLASLQERDDNIYRVIMGAEPIADEIRKAGFGGANRYRNILEQGLEREELVLENYQRIDQLKKQMYIQTKSYDEVMNLALDKELMLASMPAIQPVSNEDLKRLSSGFGYRMDPILKTRRPHHGVDFSLPKGNPVYATGDGVVKFTKTSFSGYGKQIEIDHGFGYTTKYAHLNEFVVKTGQKVKRGELIAYSGNTGKSTAPHLHYEVKIDGKPVNPVHYFYKDLDSEEYEEVLRLASIENQAMGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUK1</accession>
    <name>A0A654DUK1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MacB_PCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="17"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="776" mass="87477" checksum="E165FEC046F20B04" modified="2020-04-22" version="1">MRLFIALRKLYRDGLYTMTSLFSLIILISSCSFILVYVANELLYDSHHQNRSRIYRISSEWNSPTSTDQMAITNGQVGEYLQGAYSLISRSARVSLIGKNPGLKWKDEHIDTKDFYRSEPSVLDVFTFKMINGPGGQAALSKPGDLLINESYALKMFGTIDCLGERIQTDGETLQIAGVYEDFPQNVDLNINGLIYQSFDQRSYEQFAFYTYVLLNEGATEEQLEHALAETSARLFGDNPKYDQDIRLKAASLKGLHFVNDIKVDNPKGNLANVRLMMLAGLLLIIIVTVNLTNLNMIRSLEGLKKIALYRIMGATRGAIILNFMLELLIIWVVAVIGSVFLLDLGKGSFTALTGIELTSVHFVYIGLFYLSTLLMCLLSGMLGIFYILSARPAQGLRKFYNPSLPGDVIRKGLVTFQFVVASVLATTFSVLLLQQAFIYRKDLGYNPEGLMLLRVSDQTLQRVPIVNELEKHLGEGHIAAFWQPQMGTDELMFSSIKLISEHGESQEVVSNDMIIDQNYFEVLGIRKMMEQIPPERSSQPMAYLNQTLIDQITYDGRVAKFEYQWGTGGEVAGVVTDFHYQSMHSTIQPLVMVVNPDISSTWNGLYIRTRVDQMPQIRKIIEDQFSEEVIDLIPVDQKLEAYYSREKSVLLLLGGFMVIGLVLAAMGIYTVLAYLFRYRMFEIAMRKIMGADFRSLLVLFGKEFVSVAAFTFCLALPIAILAKDQILSAFAYRVDLHWAVHLVPIGLLLLGMFIVVLLVARRASRLNPSLILHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUK5</accession>
    <name>A0A654DUK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-Rha--alpha-D-GlcNAc-pyrophosphate polyprenol alpha-3-L-rhamnosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37669" checksum="6BD3480B91040805" modified="2020-04-22" version="1">MHKVAVVILNYNGRDHLLHFLPTLITHSPDAEVIVADNCSTDDSLAVLQQFPSVRTILLDQNYGYAGGYNEALNQVNADYYLLVNSDVEVSPNWIAPLSHFLNENKDYAAVQPKILDFNQKDYFEYAGAAGGFIDLLGYPYCRGRVFNTLEQDTGQYDSNADIFWASGACFMIRSEVFKQAGGFDADFFAHMEEIDLCWRVKSLGLKIAFVPNSVIYHVGGGTLNKTSPRKTYLNFRNGISLLIKNLPIPMLLVALPVRLILDWMAAFLFWKNESFSHFAAVFKAHAGAMRAFPSQIKLTIRSGTRLKNQKKAILPVAYYVLRKRNYEAINNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ2</accession>
    <name>A0A654DUQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024890145" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="66" mass="6959" checksum="DD7E6B96B41FBE96" modified="2020-04-22" version="1">MTKKLRLFALLGTFTLAALTISCGDDDLQSCTHCSDDAPYGTLDGGCYATLSDCESNESGNCVICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ9</accession>
    <name>A0A654DUQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="135"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="281"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="358" mass="40999" checksum="2DCC900D9353D9C0" modified="2020-04-22" version="1">MNKKNYTVEDLLNDNSFISYIMDHDSPDGREWRVRLAQTPDLVSIANEAAEVIQSLKYQDLSFTRHEEEQIWNRIDRLTSDTHQVQMGWKLRDWVKVAAVLIPIVVSTFWLISNFQKNEGPVEMVETTITKDCPNGRKMQVTLPDGSTVKLNSGSRLTYKSSFDKDLRAVWLEGEAFFDVKRNTDKPFVIISGNIRTQVLGTSFNVKSYGEEGLVDVAVVSGLVSVSRFNQSEPDRLQWDNISGVVLNPSELVSYNINEDKFSEIVEVDTDEILAWKSGILVFERATFEEIVKKLERWYGVEFEIEKSVEITDGFTGRFDNQSLRRVLEGIGYTSKFDFKIEGKKIKIMEVEKPRAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV6</accession>
    <name>A0A654DUV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845097" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="219" mass="25702" checksum="D3EB3F4A1F684698" modified="2020-04-22" version="1">MKNLFTILLFACTLSAFAQTSSPESVETKVAHKWRVSLPYFIITDRIGPNFGDWDAHTSTQMIELHVKRNLDNKNIIGLKLATWRLFQPMGIQWWDGLLDKLETESEFYPGHVRETGIGVTYQRMLWKGLFATVEVLPQFQTYLDENGDKIGNDFKLYNSYHLGYHVSIGKKKRFFIEPQVHCQHWMFDSNAPAGFKELDDKWRNYFLFEPNIYVGFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV22</accession>
    <name>A0A654DV22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chromosome-partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">parB</name>
        <name evidence="4" type="ORF">MARINOS108_10942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="33396" checksum="38114E07652458A8" modified="2020-04-22" version="1">MTDKKWKKKTGLGRGLGALLEDSEEKENISGSGATIRGAISEIPVDQIEVNPFQPRTDFNEEALEELAESIRVQGIIQPITVRALSENEFQLISGERRLQASKRAGLTAIPAYIRTADDQQMLEMALIENIQRENLNAIEIALSYQRLLSECDLKQEELGDRVGKNRTTVNNYLRLLKLPPDIQIALRDGKISMGHARAIVNIENVEQQLAIFKKAVNEGLSVRKVEELVRDLNTEKKETPKPKEQINPEIAKLQDKLTTHFGTKIQVKADSNNKGEIKIPFISAEELDRILELLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV45</accession>
    <name>A0A654DV45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="50" mass="5511" checksum="2C1027FF96382AD0" modified="2020-04-22" version="1">MGHCGLGNELIAAVLTDFRNSNVAAHDVSLKGEKMYQYVSDCISLYLYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV77</accession>
    <name>A0A654DV77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="31904" checksum="EA3D158F6F3DE6FA" modified="2020-04-22" version="1">MYSPIAIFMRQLSAVIIIILCLASCRDKIICPAFQSTYILDDSVRMAYYSYLWKIDKDERLKYLASQKPVSLDSAGAVVASVGKGIDYFAYVEPYVVTPDEVKKTKFGIVKYEPYWLKNYELRTAPKENILAPEPIEEPPVVEDVGEFIASDFSDSATVVIDSTATIVSSEEDTLDIPTLAIVEPAKPKTELKYLYRYDPNDKALNVEQAYYNKHFGQYLYTRVPIQEEVSEPLPDNPADSVSSGGFFKGLFKGKKVKSDPIIQEVEVEPSLDDAIKEDPNSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK9</accession>
    <name>A0A654DVK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="29162" checksum="E4C8C2AA1DF0F7D9" modified="2020-04-22" version="1">MFRHQGKSRTLKQNLRIASVLSFVAGIVNVTGFLSFNQLTTNVTGHFALFINDVAHFDFWRGTIYFLYIFVFLFGSFLSSFLIEQFNSSKKLNVFVLPTIIEFLILILIPVFSHLSEIKYPDLVICAMLLAMGVQNSFVTKISSAVVRTTHLTGLFTDLGIELSQLFFPKSYPNREKIKSTMKLRVYIISFFFLGGLIGGYLYSRMGLGLDTLIFGAVILIVSLFFDGLKYKVIRNRRKYQQRKTAQLRQQPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV8</accession>
    <name>A0A654DVV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046233">
        <property type="entry name" value="DUF6266"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19781">
        <property type="entry name" value="DUF6266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="22375" checksum="420268063ED46896" modified="2020-04-22" version="1">MGKISQGVLGGFSGKVGNVVGGTWKGIDYMRIKPANVTNPRTEGQVDQRSKFSTVLRFLQPMTDFLRVGFKLYANKMTQFNAAMSYNLNNAITGAYPNFMVDYASALVTRGNLSGAANGAASSPSAGDVQITWDDNSGSGSAQATDKALIVLLNTTRQEAVFTIAGPARSAGTETISVPSEYTGEDVEVFLGFISEDGSKVANSSYLGSVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ3</accession>
    <name>A0A654DVZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024833529" evidence="1">
        <location>
            <begin position="24"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="46253" checksum="D09895ECBC41F81F" modified="2020-04-22" version="1">MKNFKLKSILTALFLTGVVFAYAQQPALQYFRANDKDGLNVFETSKENDVEFTGVKVRVGGDFAMQFQGLSQTNAGDSLTELANNFNLPTANLNLDVQLADGMRMHLRTYLSSRHHTEAYVKGGYIQIDKLDFIRKDFMSGFMNVATIRVGMDEFNYGDAHFRRSDNARAIFNPFVGNYIMDSFTTEPFAELTINTSGFIGVLGATNGRLNQSPLPGDDGFVLFGKLGYDDQINDDLRLRLTGSFYSSSDKGTRDYLYNGDRAGGRYYQLLGTQTISSSDFSPRFNPGFKYQTAFQINPFVKFKGLEFFGVFEVTSNGDDAVGGSFTQLGAEALYRFGGEEQLYLGGRFNSVSGEMTDAAAARDTQRINFGGGWFMTKNVLAKIEYVKQTYDGAGWNGSQYQGAEFNGVVIEATIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW09</accession>
    <name>A0A654DW09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sortilin-Vps10" evidence="1">
        <location>
            <begin position="730"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="970" mass="107987" checksum="781991B461979658" modified="2020-04-22" version="1">MKSFPLILLLALTLATTHVSGQKLKINDTPAATSAADRWQGFLQRQSLLENSLVKNIPFRNIGPTIMSGRVVDLEVDPQDPTHFYVAYASGGLWETKNEGASFDPIFDNEIVMTIGDIAVDWTEKVIYVGTGENNSSRSSYSGYGLFKSSDNGQSWQHLGLPESHHIGRVIVHPDNPKILWVAVLGPLYSNNQASGIYRSVDGGASWEKTLYVDKKSGFVELILNPKKPDELIAASWQKDRKAWNFEESGKGSAMFKSTDGGITWLNISSGNNGFPDTEGTGRIGLAYAPSNPEIIYAILDNQDRRNEEEKETFSVTKNLLRNTTIDAFLALTNDELNDFLDRENFPDEYNAVDIKEEVKKGKVKPQDLVTYLEDANSLLFDTPVKGAEVYRSDNGGETWRKTHEDYIDALVFSYGYYFGQIRVDGQNPDILYTMGVPLIKSTDGGSTWSITDMENVHADHHALWVNPSRPGHLINGNDGGINISYDFGDTWVKCNSTAVGQLYTVNVDMAEPYNVYAGLQDNGVWKGPSNYTYSRSWLEEGKYPYERLMGGDGMQVVIDTRTNDLVYTGYQFGNYFRINTSTGDQKYITPKHQLGEAPLRWNWQSPILLSSHNQDIVYFGSNKFHRSMNQGEDFETLSGDLTNGGKKGDVAYGTLTSISESPIRFGLLYAGSDDGLIHISRDAGQTWEKIASGLPTNLWVSRVTASAHAEGRVYASLNGYRWDLFDALIYRSDDYGKTWKPIGLDLPKEPVNVIKEDPKNENILYVGTDHGAYVSLDGGESFMAFNAGLPAVAVHDLVIHPRDKDLILGTHGRSIYVANMESLQQLPGLTDDIKVFPISEKSYSERWGTKGSWHWDGYNEPQTVVEAYTSIGGTATLSISIDSLVLKSWTTHLDKGLNYLEYDFTFDSSQVKQLQKQLELESTLEARDNGKYYLPAGAYTFTLNIGEKNASAPLKVNAPRQAAKRKGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW95</accession>
    <name>A0A654DW95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4468" checksum="7B87A8BEB3C8C143" modified="2020-04-22" version="1">MDSFGVQMLIDRSDYADRKGFGERIMPSAGALMVSVCCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWF9</accession>
    <name>A0A654DWF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="2">CKS</shortName>
            <shortName evidence="2">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">kdsB</name>
        <name evidence="3" type="ORF">MARINOS108_11263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="27741" checksum="7F3C6537D7A588F9" modified="2020-04-22" version="1">MRILGIIPARYASSRFPGKALVQIQGKTMIRRVYEQAIKSQLVDKVLVATDDQRIFEEVSSFGGAVMMTSAAHRNGTERCAEVILEHPGYDYVINIQGDEPFIHPEHIDGVATLLDGDTELATLVKKITDPAVLDDPSEMKVIFNQDQEAIYFSRTCIPYLRDVKPEDRLKKHTFYKHIGLYGYRRDILLEITQLPPGTLETAEALEQLRWIENGYSIKIGLTTLESQMIDTPEDLAKLTQDMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWJ2</accession>
    <name>A0A654DWJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="39"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="533" mass="61379" checksum="18B25618EC0C0453" modified="2020-04-22" version="1">MRANLWLFSMALITLACSPMEKELKESLPDRWPNAVTYEIFVQSFADSDGDGIGDIKGMTSKLDYLQELGVEAVWLMPINPSPSYHKYDVSDYYGIHSDYGTMEDFQEFLKEAHQRHIKVIMDLVINHCSRLHPWFLNALKEDGEYRDYFVWADKAGIEAEGNLLKAKTGDSDNIHQWNEVSGQDELYFSFFWSGMPDLNYDNPKLREEIYEIGNFWLTKIGVDGFRLDAAKHIYPDHRAADNHAFWKEFKTKMETYKPEVYLVGEVWADLPTQAPFAQGFSALFNFDLAFSIMETVKNGQIVSATIHEHAWKVLDEGSPVTLFNESEKAFKQYNPGFINTTFLTNHDQNRVMSFFENHEKKAKLATSILLTLPGAPYIYYGEEIGMRGLKPDELIREPFLWETKNDSMRTQWMEPTYNTTNVVAPLSVQRKDSGSIFNHYKSLIHFRRKSAVMTYGGVEQIDLANDELLAFTRSHAGDTVLVVHNLSSRVKRIRQLEPYSLILFTSSKKVRQTADVLALPPYQTIILSKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ1</accession>
    <name>A0A654DWZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="313"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="429"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="790" mass="88347" checksum="C31FD46947F1FFF9" modified="2020-04-22" version="1">MIKNYLKITLRHLLRQPGYAALNILGLTIGIVSSLLIVLYLYHEVSFDQQHTKADRIYRISSDIKEPDNAFRWAVTQLPLGRTVKSEFSEVEQYVRFIGNGRTRFSKNDISYYEENIFMVDSTVFNVFDFNLTSGDPQTALEGPNSIVISQSMADKIFKGENPIGQLLKTDRNSLEITGVFADVPKNSHIRPNAMISASTADRNNSQNWGGFGIYTYVLLNEGADPAAVEAKLNDIIEKYVAVIFDQFGIKIRYELINIADIHLYSTFQGEPEPLGNIKYIYIFGAVAIFLILIASINYMNLSTARSMKRALEVGIRKVMGAQRGMLIRQFMTESILLTVFALFLSLLLLLILVPLLNNQLQTNLSIGNLLAPGVLLAIGIMFLITGVLSGSYPAFYLSAFKPIVVLKGKGGRAGNKVLRSILVGIQFAISIFMLVGTLIIYDQMQYLRHKDLGFDKDQVLRLVLDNDPAREKWPVLKNKLLENPNIKGATTSTTSPGRGFGKNVMSVETNDGTMEQYGVDSYGIDYDYLPVLGIDLAAGRNISSNYPTDTASAVMINEAMVARMGWSDPIGKKFQFDRDSTKFHKVVGVVKDFHQRSLYDPIEALLFIPSLNNSNVLIKVGGDLNASIRSIETIWNEVFPNMPFEYSFLDEDFMEQYETDQLRGRLFLGFSVMMIFIACLGLLGLASFIAEQRTKEISIRKVLGANVSGLVTLLVKDFIILVALGALPAFGFAYYFMGEWLDTFEYHVEMNYLLYILVLIIISAITVVTTGYHALRAASSNPAENLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX05</accession>
    <name>A0A654DX05_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="13204" checksum="9FBF6FB81DECCD78" modified="2020-04-22" version="1">MKFLANENVPVSSVNYLKSKGYDITSIGVDEAGVSDQQVMDIATKQDRTIITYDSDYGELIFKYGFKPNAGVIFIRQQPTEPLETAKIIEQLTSNTTLSFERTLTVVDLNSLRQKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX08</accession>
    <name>A0A654DX08_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SiaC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15825" checksum="427FA5E64284F221" modified="2020-04-22" version="1">MNLITNPKHEKDEKLFSIKFVEPHNLLIIKGWSITPELNTYYQATREGIIRHLTINKGLTIYFSYELLHSVTTRFLYNIVQILNQFHVLGKRVKIYWVIDQYNEQLIELGTELKALSHFSFDLSLPSTTLSSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX10</accession>
    <name>A0A654DX10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024929190" evidence="1">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="23652" checksum="1FAF14848F01EEDF" modified="2020-04-22" version="1">MYMNVKYLICALFLGYGLTTLAQSTYEAEIRQWQKELNEEFSDPDSSPLTAKEIKKFKGLEFYPINEAYRVEATLEILQNQQPFTIPTSSQQQKVFVKYAIARFELLGQAFEFPLYQSLQLQQSEEYKDYLFAPFTDETNGFETYGGGRYMDLRIPEGNTLMIDFNKAYNPSCAYSPNYNCPIPPRENDLTLEVKAGVKAWEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX13</accession>
    <name>A0A654DX13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araD</name>
        <name evidence="2" type="ORF">MARINOS108_11201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.4" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="224" mass="25152" checksum="C61B1ED59384F016" modified="2020-04-22" version="1">MCYEANMELPAQGLVIFTFGNVSAVDRQEGVFAIKPSGVDYAVLRPEDIVIVDFDCQVVEGTMRPSSDTKTHAFLYREWSEIGGISHTHATYSVAWAQAQQDIPIFGTTHADYLTSDIPCAPPMSDELIKGNYEHMTGQQIVDCFSEKGLSYQEVEMVLLGNHGPFTWGKTAAKSVFNSKLLEELARMAYLTRQINPEAPRLKEALIKKHWERKHGKDAYYGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX62</accession>
    <name>A0A654DX62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator, regulator for metE and metH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="36278" checksum="532FAFC6E5782B1D" modified="2020-04-22" version="1">MELKHFRLIKAIADEGNIANSAERLFLTQSALSHQLRSVEENLGVKIFIRNRKEWELTEEGQELYHLATSVLNSVDKKLMQIKHFSQSTGGNIKAGSECYSFYLLFPSFLQRMSALYPQISIDLNFDATHQPLSKLLSYEVDIAMVTRQPGLESLSSVEVLQDELFAVMHKENPLSQREYLEARDFTDQHLLIHSFPLETVSVYETYLKPNDVLPKKISAIPLTEVSLEMINANMGITCIPKWTLKHVIYQKELVFKPISRNGLKRSLFLVMRNEDLSKKHFTDFICNFEESIAQEFPENRVTDKPVREMSFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX80</accession>
    <name>A0A654DX80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase PhyH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="37369" checksum="941434F5D35DBF3C" modified="2020-04-22" version="1">MNPIFKDKKLDERLTTHGYLKIPLLTPALTQSLLDLYHSSVRGEEVKNSQYGLYVTLEEFDTEKSLEIENQVEQLISDQLDRYFEPYKTHLGGYLIKNPDPNGYTYPHQDWTFVDHNHYRSVTVWIALMPITQKNSTLGFARNSMTTFTHPVGTPVTIMKSGTTGHEFTVYEYLDFIDIQPGEAFVFDNRIVHAATPNTSQHSRIAYALTLSPPSAPLLHYLYARNEAGEDDLIKLAVDKAFFHDYTIEHADDLYERNELPKGYRVLSREKPTWSPMPSSALETYLTENQLQRNGLCISHHHTNPTTEKTSLTARIKQWISWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD5</accession>
    <name>A0A654DXD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bac_transf" evidence="2">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="20526" checksum="8977013A888914B3" modified="2020-04-22" version="1">MMAGWLCIVLLPLMCAIALWLLLSGQPVFFVQERPGLGGRLFKMLKFTTMTNVPGDPIFPMGKFLRKTSLDELPQLFNILKGEMSFIGPRPLLVAYLQKYTPKEHRRHEVKPGITGWAQVNGRNALDFKEKMKLDLYYVAHCSLWLDLRIFLKTFVQLIKWWESDYHAVQVKTSESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE1</accession>
    <name>A0A654DXE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="275" mass="31332" checksum="A7A697D62AEAF0B0" modified="2020-04-22" version="1">MKHILTISLAIILLACGTDDLPTASSSFLVVEGWLTDQDTQQYVRLSRSQEFLSSEANRFVSDAEIQVRSSRNEQFTFSHQSNGLYLSDIPFAGQPYNSYWIRISMPNGSIVESNMEMIQPASEIDSLAFDFYLRPSEEDPQIDEKVYYPIAFAKDEGSARNYYRWKLYKNDTLFSDPEYLVLLSDRFFDGNAYQNDFTNFEYQLGDKITVEKLEISQKAYEYLSLLKSQTTTLGTVSSVSPAPVKGNLHYLSSTTQVLGYYGVASVRQDSLRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE8</accession>
    <name>A0A654DXE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar-binding cellulase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032260">
        <property type="entry name" value="DUF5060"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16586">
        <property type="entry name" value="DUF5060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5060" evidence="4">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="562" mass="65306" checksum="758DFF3960D11825" modified="2020-04-22" version="1">MKKINTTINLLLVFAFWLTGCASLEVKQISEQPKQYDKTEFEIYVKESFENPYDAREIAVNMVLENPAGDSILLPCYYEKGESGSAVWKARFAPRSAGTYTYQFLVEKAGKIVNKSEKNTISAAASSDDGFLHINDFWTLKFDSGKPFRGIGENVGWESRSYEDPKYDYDYLLPTLANNGANFFRSWMAPNNFPLEWHKVVQTKRYSDSDEYFHPGGAQRLDEVLELCDSLGLYIMIAFDSHNTLMPGRQWEIHNYNSANGGPADTPDEFFSLPESRERYKNRLRYLVARWGYSTSVGAWEFFNEIDNAAFTKKDSIVIPHEVITDWHQEMAAYLKSIDPYDHIVTTSVSHREIEGMYALDELDLNQMHVYKRTKQIPEEILMYVSEYNKPFSWGEFGYEWDWNLDFSEFEEESDYDYKRGLWYGLFNPTPILPMTWWWEFFDERNMTPYFNSVRQISDMMLDAGKGSFERIDVESEGLQSFGVKCGETYFVCVLNNDYEQMNSAFRLQLDSGNYKVQVYDPDTREFESSNVLKAANEPVSLPDLTLKGMDEMLFVLTPTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH0</accession>
    <name>A0A654DXH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018706">
        <property type="entry name" value="DUF2214_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09980">
        <property type="entry name" value="DUF2214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="15836" checksum="60BF93896F45D25E" modified="2020-04-22" version="1">MDYILIKYVHFLGVFAVVGSLFAEAILVKPRMTRAELFFLSKVDAVYGIGALVAVAAGLLLWFGVGKPAGFYTQNWIFLTKVGLFSTVGLLSIWPTVFFLKMRKGDPEEVVSIPGLIRLMVRVEVALLVVIPALAVLMANGIGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI8</accession>
    <name>A0A654DXI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="24052" checksum="C24D187B14A5E7B1" modified="2020-04-22" version="1">MTKKTNIRKLSDDDSFKGWFEEVYEANFERLFRYAFSITKGKQLAEDVVSEVFLNIWNKRPDYSNIQELGSYLHVSVKHLAIRMASKDLRRFSYSNYDETLQISDAVDPENLLLGKELDELVTTILSDLSLHNRVVYDLAKNKGYTNQQIADELGISKRTVESHLHLALRKIKEGLREHFKESDKNYHFFTSIGSLSALVISTLLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK2</accession>
    <name>A0A654DXK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19705" checksum="069AF886EE918B65" modified="2020-04-22" version="1">MEGPKELYHEEIKKLKDFRVRLDTHAIYKKDLEDFSDDYEDLVAQAKVITRVSDRLQKKLDNANIQIREQNDEIKDKNLELEKTIKDLAEAKVGRKASTIMFTLAIILFLSEEFFLEDIIESNVSIPYVDLMAKGLIAIILKFFESGLESFFLNQEKRKIIKQEKSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP5</accession>
    <name>A0A654DXP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025024702" description="Metallophos domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1218" mass="138682" checksum="D99AF382FAC7B58A" modified="2020-04-22" version="1">MRLLFSLLLIAVSTLASGQEVSVYLIGDAGAPTSPDRNLDFLQKITKEAKATDVLIFLGDNLYPDGLPSKEDPARGTMENKLNASLNIMKAFKGRSIILPGNHDWSRGGKDGWKKVLNMQRYVDEYMGTSTVFLPRDACPGPVEIPLTNALTLLIVDTQYFLHPWDKPGREDGCESKSTAEALEELDDLLKRNADKLVIVAGHHPMHSYGPHGGQYTLKQHIFPLTDVNRKLWIPLPILGSIYPIFRSVFGSRQDITNPRYKLVRNTMVKSFAQVKDLVYVNGHEHSLQYIRKDSAHYITSGSGSKSSNVSDGANSLFSSAKRGFAQLTYHAGGSVDLKFFNGDLQEKIYDSPIYTKKVNHKSNEMLKANYSDSTVVRPISLRYAIKSNTHEFWLGENYRQLWSTPVSMPVFNIDQEHGGLEILKLGGGNQTKSLRLEAKNGRQYVLRSLDKYTTKLLAAPLYETLAADIVQDQISAANPYGVFAIPPLAEAAGIYHTNPQLMYVLDDPRFGPYQSLFAHMPVLYEERPNDDAASEDYFGGGEKIEGTPDVIATIQGDNDEVIDQDFALRNRLFDMLIGDWDRHEDQWRWVRLDQSDKGHYWRPIPRDRDQAFFVNEGMIGWAASRKFALPNTEGFDEKMDYPPGFNASARFFDRTFLNALDWSQWEKQIDILNTRLTNELIDSAFNVWPDTIRLQAAQETSRILKARRDDMRRYARIYYLFLSREVEVVGTNKHEYFLVERISNEATRVTVHKRKKDGEVLQIIYQRTFLSSETEEIRLYGLEGEDVFEIKGQVKSGIRIRIIGGEDNDKITDHSRVNGLKHHTVVYDLKQNTQLHPSKETKSRLSNNINVNAYNRTAFEYDKLIPLASVEFNFDDGLFLGGGFILTKEGWRKDPFAARHQLKINGAFETGAVNLYYNGTLSDVIEWWDLNLDFTLQRPFGVSNFFGFGNESSYDFKGQGDASGFEDEIDFYRIRFERSQTYLNLAHSIGAKGSFRMGPEHLSYELENKIQDRYIHQPNSGTDPEALYKSHQYVGYRAEIATNTRNHPELPTSGVFAQLIYGSYYGLNARSRNFSTLKGEFIFYLSTRIPSKVTFANRIGAQFNEGSLEFFNGAILDKETLRGYRRGRFIGEASLYHNFDLRAKLFSFKTYLFPASVGILGFHDIGRVWLKSEQSDTWHTSKGFGLWVAPLNQLVVTANMAFSKEETLPTVTFGYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP7</accession>
    <name>A0A654DXP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024861618" evidence="1">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="33120" checksum="7D859FB5AA702407" modified="2020-04-22" version="1">MKISIRYAFTLLIGSAFALALVGCGGSSNEKSAKEAAFEEAEKKISSDLDQVIHDLPSPTEVPYMLQATGSDFNGTLINGLENLSKYETNEEEASLNLGVYATDMGYLLSYEKVSESRQYMEACQKLAETLGVASVFDVKTMEEFQGNLNNPDSLSKILSRAIVEAETRLESSDRVSVAALILTGSFLEGLYLAVKVIETYPSDILDETNRNLILEPLVKVVLDQKKPLLDVIAMLKDLPQNDAIAKMITELSILRILYDGDLADIQAKIASNEGNFILTQDMLIDITTEVKRVRNDIVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV6</accession>
    <name>A0A654DXV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="362" mass="40274" checksum="0E154FC4A92E2531" modified="2020-04-22" version="1">MKHLIYILGIVFVASCQTTPNDTTSEGMESDTLKYEQEIHLKNVKQLTWGGNNAEAYWSFGGDQLIFQSDFEAWGVACDQIFKLDISKAEAGYRPPMISTGLGRTTCAYFLPGDTTIVYGSTHLGDSLCPESPMRSASGKYVWPIYADYDIFTADLNGNILKQLTHTAGYDAEATVSPKGDRIVFTSMRSGDLELYTMDMSGENVIQITDELGYDGGAFFSPDGEKLIFRASRPKTEEEIATYKGLLAEGLVQPTEMELFVCNADGSDLKQITKLGNANWAPFFHPFGEKVIFSSNHEAERGFPFNLYMINLDGTGLERVTFDSVFDSFAMFSPDGKYLVWASNRFNGGNRDTNLFMAEWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ4</accession>
    <name>A0A654DXZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="330"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="44827" checksum="D74327B17D4CA020" modified="2020-04-22" version="1">MIMRTPLFIFVSLVLYSCTQSSPDYLSQARRDLSILASDSLTGREVGTEGEALAAAYISKRFEELGLQPAGTAGWNQPFFVKESQNPHEKPLLSAEDSTAGTSGKNVIGLMDNPGDEVVIIGAHFDHLGYGGFSSLHRGDSAIHNGADDNASGITAMFLIAEMLQSKNIQTDVLFIAFSGEEKGLWGSNFFVKNPTIDLSTVDFMINMDMVGRLDSAKGMAIHGTGTAPQWSQVIDTTNTVNLKVIKKASGIGPSDHTSFYLQDIPVLHFFTGQHEDYHKPTDDAELINYEGIVRIATHITNIITYLDTQPKLTFQKTKDESSQGPRFTVSLGVVPDYLYDGKGMRIDGISEDKPAQKAGLEKGDVVIQLGDSTVIDMMSYMRALSSFKAGDATEVIVNRNGEKLAYDIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY46</accession>
    <name>A0A654DY46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17948" checksum="BF18BDD85F979F32" modified="2020-04-22" version="1">MEPKTKIHAEDGKQELLITRAFDIPLELLFKAYAEPHLVEQWMGTKVLKLENKRHGSWQFETTDPRGNKHGFNGTIHEFIPNEKITRTFEMDNTGFGVQLEFLEFETLTDKTSQLIMHVVYRSVAIRDQILQLPFAQGINMAHNRLEKILTQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY62</accession>
    <name>A0A654DY62_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ORF">MARINOS108_12002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp_2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="7">
        <location>
            <begin position="278"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD14516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="403" mass="43401" checksum="E53DB325CC085597" modified="2020-04-22" version="1">MNIHEYQAKEILKSYGVTIQEGIVADTPEKAHEAAKELNRETGTEWYVIKAQIHAGGRGKGKINETGSNGVVLAKGLAEVKPKADAILGGTLVTHQTGPEGKKVNKILIAQDVYYPGESEPKEYYLSILLDRAKGCNVIMASTEGGMDIETVAEETPEKIVKEWIDPAVGLQGFQARKVAFALGLEGQAFKEMVKFIFNLYKAYEATDSSQFEINPVLKTSDNKILAVDAKVNVDDNALYRHKDIAEMRDLSEEDPLEVEAGQNGLNYVKLDGNVGCMVNGAGLAMATMDIIKLSGGEPANFLDVGGGANAQTVEAGFRIILKDPNVKAILINIFGGIVRCDRVANGVVEAYKSIGDIRVPIIVRLQGTNAEEGAKIIEESGLKVTSAIVLKDAAEKVKQVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI4</accession>
    <name>A0A654DYI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="23152" checksum="23CFC441CF9B12BC" modified="2020-04-22" version="1">MAFSVKFGSDSELVTRLRDGDEYAYSKLYEKYASKIYNISRKMGLLHEDAEGVVQDVFMKIWRNRENLDSSLSFNAYIISIVRSIVFKQSRKRARFLAFQHYAITYWPGESNETEEYVIFSDLDELSSKAIDELPTKQKQVFMMKNFEHLTNEEIAERLKLSTRTVENQIYRATKSLREKLIEMKVVAPGVVGLIFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN8</accession>
    <name>A0A654DYN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15506" checksum="5E39B075020C26C8" modified="2020-04-22" version="1">MSTIKISARGIDEINSVYKKIKKEYKAVDTIRLNQDTMDYELILAKNELDGYLKSICDKVIDNDELLEEESVFKDFGWKKFSAALAVERVSIPLRSLKTIWNDLSDEKKRACFDYLCEEKELTPVEGEGDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR7</accession>
    <name>A0A654DYR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9801" checksum="D84B88FB3F7A02CC" modified="2020-04-22" version="1">MFDGSDFPKPLDEALFDQWLENGRQSKISYGFLLIVWDAFEAAYQPVYAERREQMQEYQRYQESTGRESLVAAYNLYSESRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT3</accession>
    <name>A0A654DYT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024820511" evidence="2">
        <location>
            <begin position="24"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="594" mass="66401" checksum="8C1839BD80C1CC3A" modified="2020-04-22" version="1">MNRALIYLFFSVFLLSLSVPVWAQDTEEDPYADYSYLWEDTKKKKKKKKKNDAPEVKTVPDYEPVQPEEEAIYTPPADPLIDESPVDSLQQEEELRLDSLEEAPQEEVQYPVDSLDKPIEKEPLEELNEEEYQEIEKAPKEKKERKDRSGAPPVQDFRSGMGTESGGGSFDGGLTVTQIDDQYFVGLVLNPEFSIGKVGVGLNVPVLYGLDDQSIRTEIFKDGVGAARLITYIRYGVQKADPVYVKVGQLNNTMVGFGGLINNYTNSTSFEKRKVGLHYDLNVKGLAGIDGVYSDFSPGSFNLFAIRPYVRPMAWTPIPIVRTFEFGATIVRDKDQSKIVTSDSTSTSYLFTRNGIGAFGLDMGVTLLRVPFIQIDLFATYSKLNVTSEVLTDSLESNYATTNEPSIMSDGFENGSGASVGINFRFHFIADILSTDVRIERLNYSDHYLPQFFDATYEINKDARIYALGGAEKMSGFYGSLTGHILKKVQLGGSLMIPDDVTEATPATVRVNADLDRLADKFSFHGSYIKGNLTDLGDTFKFDERSLAKLRVIYHLNKFLAAGFDYYWAFTPTADGGYKPTKYVSPYFGVSVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU5</accession>
    <name>A0A654DYU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="786"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="861" mass="93723" checksum="7C4FC66E4D2BD38E" modified="2020-04-22" version="1">MLFILLSIAVHGQSYEVPITLPQYNPEDPTMVLIETNEDWNMINNPDKTYFFVTPGDYTALGEIEISTPGTAETPRWLVYYNPENSADLVTHPVDMSADQRAEFERIELSGSHWIVDRLYGTATAGSKNPTLDLHGANIIVNRMLCEGGGGGAGQVAINASNIVVQNSVMRNTQIIPNSDIHGMKISGGFDVRIVNNEIYNFAGDGVQLGDKPESFKGVIIYNNDFYIDLSLYPEEVDEIPHENAIDIKQAGVPGGPQNYVLIKNNRFRNIAHTPGGTSPNPDQGTIDFSNKNDPKSHVLVEGNVFYDCKIPFNTKGGGQTSNFTITKNLIYNASRFGVWMDAEETYNHEVTFNTIIGVAEFNGDQEWLNTKCQQLEVYGNLIFNGHGITLPEANCKSDYNVFFNTTLPAQEGSHSIVLESINASDFEDYCYPFKMHTNPETLCIPGARPTQSAAFTNLTATQYFGETAGVGVNDQSYNQDWVGALSPAHVTGFPSVDFQYLADTLVGIVNIEVLAADEDNDLTGVQLFLDGGALGELMENEPYSYSWDTKSLTDGSYTLKALATDQAGNTTYSDPITRFLDNTPDSPPVVALTTPEDGATVANEVILTATASDPDGDLVGVQFILEGAALGVERFSAPFERVWFTKTVPDGSYQLWAVARDMGGREFVSDVVNVTVDNSYPPLVSIVNIAGDSILSGDVEILAEVSDVDDDVTSVEFMAGDQSIGTVTAAPYSLIWGTKDFENGEYKLVAIATDSDGNAVPSRAVSIEVFNHVLEVTLRRPHAMIFPNPASEYFMMGGIADHTTYAIYSIHGEIIAEGLLQSHQPVDISGIPDGVYMVLVGTQSGEQVTIKMIKSGKNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ59</accession>
    <name>A0A654DZ59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA domain-containing membrane protein RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="136"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="268" mass="30007" checksum="3951B1B56B3ADAE0" modified="2020-04-22" version="1">MLLATFTFTLMKVCVKLIPHIPAIEIILFRSVISLVISVFYLYQQQVSVWGNNKPILLLRGVTGAIALITYFSLLQQIPLATASTLQYLAPIFTAILGIFLVKEKVRSWQWLFFAISFAGVVVVQGFDPRISTLHLLMGVGASLFMGLAYNFIRMLKTSEHPLVIIFYFPLVMLPVAGLWSVMVWVQPVGWDWLVLLAVGLCTQIAQFFMTKSYQSAELSKVSILNYIGIVYALGFGWLLFDETFNLMTYVGMGLVLAGVIGNVVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ93</accession>
    <name>A0A654DZ93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="6997" checksum="3A9BFFB2A1999534" modified="2020-04-22" version="1">MLCFLIKREINGFMEIEEGRFCSMGFYLMSGSGLKNEPIKYLIAGCGSVPSFTALVQHPSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA5</accession>
    <name>A0A654DZA5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB</name>
        <name evidence="12" type="ORF">MARINOS108_12006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="210"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="406"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD14528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="577" mass="62922" checksum="C9F584BCF220CE70" modified="2020-04-22" version="1">MNSPSLAVEKEPKQSTIKVSGAEAVLLCLIEEGVDVIFGYPGGAIMPIYDALYGYADKLNHILTRHEQGAAHAAQGYARVNGRTGVCFATSGPGATNLITGIADAQIDSTPLVAITGQVPSHLLGTDAFQETDVVGISMPVTKWNYQVTRAEEIPEAIARAFYIAGTGRPGPVLVDITKDAQFGEFEFSYKKCTKIRSYHPYPILEEDKIAAAAKIINEAKKPFLLVGHGVLISEAQKELLAFAEKANIPMASTLMGLSAVPVNHPLYVGYLGMHGNYGPNIKTNECDVMIAIGMRFDDRVTGDLKKYARQAKVIHIEIDPAEIDKNVKTTVAINADAKQALQSLIKQTESNNHQAWIAEFRECDKLEEEKVTKKEKFPTEGPILMAEVIRMISDKTEGKAVIVTDVGQHQMVASRYYEFADTDSNITSGGLGTMGFALPASMGAQVGRPDRTVIAVIGDGGFQMTIQELGTIAQNNLGVKILILNNNFLGMVRQWQQLFHDRRYSFTELTNPDFQKITEGYGIKTNKVSERAALNAAIDEWLADKGPTLLEVVVEKEENVFPMVPSGASVSDIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF9</accession>
    <name>A0A654DZF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_12111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="205"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="340"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="560" mass="63141" checksum="CAAB036E6AAFCCDB" modified="2020-04-22" version="1">MGLSRFLINVHDDLSGLERRKFVVLKKVNFVAIVVALALMCINGFSGLVLQSLACLLAILLIFLPVILLLNRGRYHFAASLFTFGLLAMLSGVAYSNILIDRKTHLEVIIIGLSVIAPILYEGWWRRCVFACIFLALCGLEALKYISHDIPLPSDYWFALLNYCVAFLLIYFFSAVFRDELARSIEEADRLNEKLTSSEEQLKKSKLMMDSLLNNLPLFLAMLDRKGNYLIVNKKYEDAFGIPIQEIIGHHYRDVLPDEIVAFHDPLIEKCLAGTPQDFYQNISQENGAFTHSYGKYFPIFGEDNQVEYVTVFVTDVTELKEAEHKLRELNRTKDKLFSIIAHDLMSPIDTLKNTLYLQDHGELSQEEMKRYTQSVRENLSGLSHMLDNLLSWAKAQFHGAPSHKSAVCLHQLIEESAGLCEEILRKKQILLRNEVSTDLILQVHENDLRVIIRNLLNNALKFNREGGSIYVSVQTESESIVCTVRDEGVGISESRLEQIRGRVVMDSEMGTSGEKGTGIGLSLCSELATRNGWGIRVSSKKGEGAAFTVVMPVNGLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ6</accession>
    <name>A0A654DZQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized transporter YclF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yclF</name>
        <name evidence="10" type="ORF">MARINOS108_11053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="16"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="494" mass="53511" checksum="9B26204ED618FF53" modified="2020-04-22" version="1">MSSESTFFGHPRGLATLFFTEMWERFSYYGMRAILILFMTTETAQQGLGLDVETSAAVYGLYTAAVYLLSLPGGWLADNVFGQQKSIWYGGILIMVGHLILAIPGSQEIFFIGLGFVAMGTGFLKPNISSIVGDLYGDDKGAKRDAGFSIFYMGINLGSLLGQTVVSFLGEKVDWHMGFGAAAVGMFLGLIQYKLTLGTLKGIGMKPEKKVKLPGEKSGATFTYALTAGAILLIFVMQYLGIVDVTTARGIAESVGVLIVVVTLAYFANIFISGGLDMAERKQVFVIFLLFIGASVFWAGFEQAGSTLNLFARDYTDRMIFGYELPAGILQNFNPFFIIILSPVFGAIWIRLAAKQMNPSTPIKFGFGLIMMAVGFLVMYFAAVIVVQGTKAGMGWLIVTYLFHTTGELTLSPVGLSATTKLAPRKYYSQMMGIWFVATALGNLIAGLFAGGFDPNDASQVPGLFMSVVLLGVGSGIMFLIFSGFMRRWMGNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW4</accession>
    <name>A0A654DZW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="25818" checksum="8A3376ECBCF383AF" modified="2020-04-22" version="1">MEHLKGKRAIVTGVSKGIGLEMARQLLDAGVEVAGWSRSQPELMDDHFHFIETDVADFDSVASAYRESVSRMGSEIHILINNAGYGVMGPVDELNVEDWKGMFDVNVHGLMYCTKMVVPQMKKMDQGHIVNISSIAGLNGVKNMSGYVATKHAVRGFGHSLMMELRDWGIKVTNVYPGSIKTGFFDQIDSIAANDNMMRPEDVAKSVIDLLNTHPNYLPVDLELRPLRPKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E061</accession>
    <name>A0A654E061_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="27028" checksum="E1549B3772601456" modified="2020-04-22" version="1">MEEKRENKVAVITGATGGIGFEVAKRLGKDGFTVVLNGIEDEAGAKRVEELASEGITAEYYGFDVTKDEEVTSNIKAIGEKYGKIDVLVNNAGGLGGRSRFEEMTTEFYRFVMALNLDSVFFASRAAIPYLKKGENASIINYTSNAGWNAGGPGAGVYGTSKAGVHAITRALAKDLAEYGIRVNAVSPGTIDTPFHSEIKSTKPEVFASWKNNIMLGRLGQPEEVASVVSFLAGKDASFITAETIQVGGGQALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F1</accession>
    <name>A0A654E0F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein SCO1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="24507" checksum="1B31AF7421065219" modified="2020-04-22" version="1">MNKFNLLFLLGLTLSGCGEVKSNYELPILGRSEINESVVNGETVYDTIYHTIPDFQFVDQDSSLITNETFSGQVYVADFFFTSCPTICPVMKQQMLRVYEAYKDHPEVAILSHTIDPEYDTVALLNDFAERLGVSSNTWHFVTGDKDEIYDIAEKSYMVVANEDETAPGGFIHSGAFLLIDQQRRIRGVYDGTVPEQVDILIHDIARLTTKNTDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W5</accession>
    <name>A0A654E0W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="184"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="346"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="422" mass="48471" checksum="4F00ADC8A402A347" modified="2020-04-22" version="1">MSQSQATLADPALDYLKRFKSIRKQTLNLVEPLETEDLVVQPVSDVSPPKWHLAHTTWFFEVFLLVPNLDGYELFNKDFPFLFNSYYVAAGDRWARASRGHLTRPTVQEVLAYRTHVEEHMERLLLQQPLSPELTHVIEIGLQHEQQHQELLLYDIKYILGHNPLFPPYKEDPTEGSDGSSPLEWLAVNKGNYHVGHQGEGFCFDNEQGRHEVHLEAYEIASRTVTNGEYLEFMQDGGYTNHQHWLSDGWDWLGNQAVKAPMYWINEGGHWLHYTLYGLRPIDLNAPVMHLSYYEANAYASWKGCRLPTEFEWEVAVGIHQAGTPENGNFVEGGHLAPKAQSDPGFMGNLWEWTSSAYLPYPFYKAPDGALGEYNGKFMINQMVLRGGSFATPKAHIRATYRNFFAPQCQWLFSGLRLARHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W8</accession>
    <name>A0A654E0W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4528" checksum="674A546797C3AE33" modified="2020-04-22" version="1">MVVFLGVVDKVNKMCINIKSQISITDLFLLKPQPNLSPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E105</accession>
    <name>A0A654E105_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar O-acyltransferase (Sialic acid O-acetyltransferase NeuD family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="22364" checksum="76A31292FD5B1060" modified="2020-04-22" version="1">MEKPVIIFGAKGIGKAALEIFKSNRVVVYGFLEDDAEMHGQEIDDVTVLGKTDDHGFIKLIGQKTEAFVATDDNALRKRQVKMLMDTRKVMPTNAIHDAAIISNSAVIGHGNFINARVTLGANAVIGQHCLIHTGATIEHEVKMGDFVQVGAGTTINSGVEIANEAFIGSGSLIVAGVKIGKKARIGAGSVVIADVADGKTVFGNPATVIDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E185</accession>
    <name>A0A654E185_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025059210" evidence="2">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22537" checksum="2A5EC4FC30C342DF" modified="2020-04-22" version="1">MKRIVTLLLLVFFVTVGFNASAQMSKSEQKEWKKRIKALEPEQYKVLIEENKSLKSQTASLKNELAGVDDKLADKDEQISSYQAQVSKLRDELAEANTRPAVPANADQGGINENVGVVFKVQIGAYAKKDLAKFDQAKNFSQEKDGNLNKFTIGAFRDYWEADTFKKYLREMGVKDAFIVSFKDGKRVDIKEVLEGVTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B5</accession>
    <name>A0A654E1B5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">MARINOS108_20032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13666" checksum="B10780B5441DC4F8" modified="2020-04-22" version="1">MNIPENLRYTEDHEWVRIEGDEAIIGITDFAQGELGDIVYVEIETEGESLNSTDVFGSVEAVKTVSDLFMPLSGEIIEVNPKLEANPELINSDPYGEGWMIKVKISDQGDSLLSAESYQELIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G6</accession>
    <name>A0A654E1G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024885839" evidence="1">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="359" mass="39421" checksum="C8381A77F568535C" modified="2020-04-22" version="1">MGKGVFVFIFGMLCSIVLPAQDNTPKYSNEFLNIGVDARAFGLGLSMVSHTADASSGYWNPAGLSKMEPDHQLVLMHSAYFAGISNYDYGAFATRLDDSSALSVSVIRFAVDDIADTRLLFDANGSVNYDNIRFFSAADYAFLISYSRRLRVLGGLDVGGSVKVIRRIVGDFAGSWGFGMDVGLQKTWKSWNFGLMGRDLFGTFNSWSIADEELAEVYAQTGNELYSRSLEVTLPRVILGASRTLSFLDQFSLMTSLDLVTTTDGKRNTLIRTESFSVDPSLGVELGYKQLAFLRGGIGQFQQIKDFDGSQSWTFQPNVGIGLKIQEVAIDYAFTDIGDQAAGLYSHVFSIKVDFNVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E217</accession>
    <name>A0A654E217_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">pyrD</name>
        <name evidence="13" type="ORF">MARINOS108_120328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="49"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="115"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="320"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD16646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="37538" checksum="7F6F19CD003FDB47" modified="2020-04-22" version="1">MYQLAKKFLFSMPAEKAHHFTTKTMRASFKIPLVKAIFKSIYQLEHHKLERKLFGLTFKNPVGLAAGFDKNAEFIHEFAAMGFGFIEIGTVTPLAQPGNPEPRLFRLPGDHALINRMGFNNKGMHAAKENLQRKPKGIIIGGNIGKNKVTPNEQATDDYLKCFDVLYPEVDYFVVNVSSPNTPDLRKLQDKEPLEALLRSLQKANRKKPNQKPILLKIAPDLTNSQLDDIIEIAGNINLDGIIATNTTIDRSGLQESAENLESIGAGGLSGAPVFKRSTEIIQYLRAQNRDIPIIAVGGILSGADALEKLAAGANLVQVYTGLVYKGPALIKEINQAILANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E234</accession>
    <name>A0A654E234_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="52" mass="5570" checksum="7F12D975EE9337A6" modified="2020-04-22" version="1">MGGWAKVAETVSKSSTKTAKDLGTPLVKGAVRDSRESKVDRLFMSLLGFKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E270</accession>
    <name>A0A654E270_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="57" mass="6669" checksum="B740AD52B9DF6558" modified="2020-04-22" version="1">MTALDTLIQEAKHLPLDQKSSLIKYLSHALIEEQILDLQKRRGMEQIRTALRRGYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D6</accession>
    <name>A0A654E2D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetylglucosamine-6-O-sulfatase</fullName>
            <ecNumber evidence="7">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024919011" evidence="4">
        <location>
            <begin position="26"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="427"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="547" mass="63605" checksum="0A6DB88766C999D9" modified="2020-04-22" version="1">MIKMQNLYKTNTAAFIAMSFLVLFSACTPKEKPVDSRPNILFIMSDDHAYQAISAYSDHLIQTPNIDRLANEGILFKNACVTNSICAPSRATILTGKHTHINGKIDNLSAFDTTQVTFPQLFQEAGYQTAMFGKLHFGNNPKGVDDFMILPGQGDYLNPDFITPRGDTTIMGYVTDIITDLTLNWLKEKRNPEKPFLMMYLHKAPHRNWWPRGDKFQKYSKMTFPEPETLFDDYKNRGTAAKTAEMNILKHMKYNSDSKVRHETTDRMGEVLPVVPGNQTWGYKTYARMTDKQKAEYDNVLDSISDYFETNWPTMTDEEKISWKYQRYMQDYLACIESVDENVGRVLDYLDESGLAENTMVIYTSDQGFYLGEHGWFDKRFIYDESFKTPLLIRWPNKITPGTTNEEMVQNLDFAQTFLEAAYINAPGDMQGESLMPLLTGGDSLWTRDAVYYHFYEYPSVHMVKRHYGIVTKEFKLVHFYYDVDEWELYDRLKDPKEMKNVINDPAYTDQVADLKARLARLRLKYKDSQELDKKFVKLAEDRQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L2</accession>
    <name>A0A654E2L2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">glyQS</name>
        <name evidence="9" type="ORF">MARINOS108_20492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="165"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="374"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="262"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="334"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="515" mass="58773" checksum="C22A5442157CE254" modified="2020-04-22" version="1">MANSEEAATLKNIASHCKEYGFIYPSSEIYDGLAATYDYGPYGSELKNNIKEYWWKAMVRLNENIVGIDAAIFMHPTTWKASGHVDAFNDPLIDNKDSKKRYRADVLIEEQMAKLQAKIDKEVDKAAKRFGDAFDKDQFTATNPRVVGYAEQIAEIESRMKSSIESGDLEALKQLIVDLDIADPISGTRNWTDVRQFNLMFSTELGSVAGESGKIYLRPETAQGIFVNYLNVQKTSRLKPPFGIAQIGKAFRNEIIARQFIFRMREFEQMEMQFFIQPGTEMEWYEHWKAKRIAWHKALGLGDDNYRFHDHLNLAHYANAACDIEFNFPMGFKELEGIHSRTDFDLGAHEKFSGKKLKYFDTATNESYTPYVLETSIGLDRMFLAVMSASYVEEKLADGSERTVLKIPPVLAPVKVAVLPLLNKDGLPEKAEAIMRELKLDFNAQYDAKDAIGKRYRRQDAIGTPYCVTVDHQTLEDSTVTIRERDSMEQQRVSIEELIGTLEEKVSMKTLLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y3</accession>
    <name>A0A654E2Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="35060" checksum="C02E466DC522AEB2" modified="2020-04-22" version="1">MTKKKVLITGGAGFLGSHLCDRFIAEGYAVVAMDNLLTGDISNIEHLMGHKDFEFQHHDVSKFVHVAGDLEYILHFASPASPIDYLKMPIQTMKVGSLGTLNCLGLAKDKGARMLIASTSEVYGDPLVHPQTEDYWGNVNPVGPRGVYDEAKRFQEALTMAYHTFHGLETRIVRIFNTFGPRMRLDDGRVLPAFISQALKGEDLTAFGDGSQTRSFTYVDDLVEGIYRLLKSDYASPVNIGNPEEITINEFGEEIIRLTGSKSKISYNPLPKDDPKQRKPDITLAKELLGWEPKYTRSEGLKPTLEYFKKKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E331</accession>
    <name>A0A654E331_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein YtsP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytsP</name>
        <name evidence="2" type="ORF">MARINOS108_20605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17128" checksum="F874D5E282B709A0" modified="2020-04-22" version="1">MAEELNIIHTTDKREKYASLIPQIESLIADEEDLIANLANIAAALKYGMDFFWVGFYLVKNDQLVLAPFQGPIACTRINKGKGVCGQSWATGQTIIVPDVDQFPGHIACSSDSKSEIVVPVIKDGAVIGVLDVDSDQLNTFDEVDQEFLERLVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E390</accession>
    <name>A0A654E390_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="2">
        <location>
            <begin position="272"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="40393" checksum="3F58D25195F0285D" modified="2020-04-22" version="1">MDFKEFEVGDFLQNEFFVDWVIHQHPEADHFWSNWLKRHPEKVSDVEMARELVKSIHYKQEHSMKSDEYSILMERILQHKAPRGAIRSVSNFVLRHSYRVAASLLFLLGFSLIFYLNYNDSVPANEPSLVWKVAATEYGQKKTVQLPDGTRVMLNSGSTIKYPEGFGPNLRLIKFEGEGFFDVAHNPERPFVIESGAFTTRVLGTSFNLKHFEEETEASVSVLTGKVEVQTETGRSTILLPNEMGVYDKESNDLRRQRFDQRKSMAWTHGTLLFENEDLLTIFGQLEKWYGVTFEVAEGTRLAGKYSGEYKQKSLELILEGLSYTSNFNYEMNHKTILIYERKKVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C2</accession>
    <name>A0A654E3C2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">MARINOS108_10520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="218"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="228"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="247"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="453" mass="49938" checksum="8B9D9F8641D52150" modified="2020-04-22" version="1">MNMNDTIIALATAPGVGAIGVIRVSGPATIAIVNSVFRGKDLTEVPSHTIHLGTIRDEEKIVDEVLISIFRGPNSYTKEDVIEISCHGSPYIIQQLIRLLLTKGARLAKAGEFTQRAFINGRFDLAQAEAVADLISSENESMHQAAMNQMRGGFSQEISKLREELVHFASMIELELDFGEEDVEFASRDDLKKLIYSLKGLITRLTESFTLGNAIKNGIPTVIAGKPNAGKSTLLNALLNEEKAIVSDVPGTTRDVIEDVINVDGIAFRFTDTAGIRTTEDKVEAIGVERTYAKMKEASVIIYLIDLINDTKEDIEKQLAYLKALKVPYLLIGNKMDRADANLLNALESENALMISASQKENLENLKEALKTLVSLDDFKTGNTIVTNLRHYESLMETNKALDQVIDGIDRQVTNDFVAMDIRNSLFHLGQITGEITTDDLLENIFSKFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C4</accession>
    <name>A0A654E3C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="353" mass="40549" checksum="DEF38695B0AABF72" modified="2020-04-22" version="1">MLKDLIQNVSDLSFPVVHIIIGLVAGVIINWVVAISLTITVKKAKSNDLLIFRKWCKTAFNTLVPVASIFIVLNYAEDTDTSRILIKTFLILLIIASVHFLIRVLYAMEDIFLDRYDIDKEDNRKERKILTQINFLKKVFIVVIVLIGFALILLSFEEGRKYGQTLLTTAGVASVILGFAAQKSISNFLAGIQIAFTQPIKMDDAVVVEGEWGWVEEINLTYVVVRIWDWRRLILPITYFVEKPFQNWTRNKGEIIGSVILHLDYRTPVEKLRSKLEEILETEPNWDGQVKSLQITDTKEYTMTVRALMSAKNSPMAWDLRCSVREKLIAFLQKEHPESLPVQRLDIHATEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D8</accession>
    <name>A0A654E3D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 16" type="primary">guaB</name>
        <name evidence="16" type="ORF">MARINOS108_20593</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="387"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD19140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="489" mass="52560" checksum="F305EB6792F3F4BB" modified="2020-04-22" version="1">MNLDDKFLFEALTYDDVLLLPGYSEILPRDTDTSTRITRNIRLNIPLVSAAMDTVTEAELAIAMALEGGLGFIHKNMPADQQAAQVRKVKRSQSGMILDPITLSHDSVAGDAEKIMRENKIGGIPVIDQNKKLIGIITNRDLRFQKNMKRPIREIMTTENLVTAEVEVGLKEAEQILQEYKIEKLPIIDKDGKLTGLITYKDILKNKDRPNACKDEYGRLRVGAAVGVTPDMVDRIKALVNAGVDVVSIDTAHGHSKGVIDAAKNVKKAFPDLELIVGNIATYEAAEALAAAGADAVKVGVGPGSICTTRVVAGVGVPQLSAVYEAAKALKGKDLPIIADGGIRFSGDLVKALAGGASSVMIGSLLAGTEEAPGEMIIYEGRKFKTYRGMGSVEAMEDGSKDRYFQDAEDDIKKLVPEGIVGRVPYKGMVSEVLYQLTGGLKAGMGYCGAGTIEQLHNAKFVKISAAGVAESHPHDITITREAPNYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E4</accession>
    <name>A0A654E3E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative OmpL-like beta-barrel porin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BBP2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="353" mass="40043" checksum="B75577F270ADC56B" modified="2020-04-22" version="1">MRKTIYFIFICVFFLKFFNAKAQESKIKFGAYLDTYYSFDFSKPLDNQRLYVTQYDKHNEFNLSHAWVSAAYEEDKVRASLALQVGTYPANNYGAEPEKLYQMVYEAYAGYQVTKKGWLDVGIFGGHFGYESALSLDRDLYSPALATEYTPYYQSGLRYTHDLSDKTQLRAVVLNGWQNIGETNNKKSLGIAVDHTLNESFKISYGNYYGNESTNSNMDLMRFHNNLILEAKPLKNWKIAGVLDYTTQSNSATDKNLHTSFITVISKYTFSEKWSVAGRYENINDKDDLLINGITGQFAMNVISLSVNYYPTENAAFKLEAKTYKGPYNNFAGEEGVGAGLLVLGAGMAIRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J2</accession>
    <name>A0A654E3J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sigma-54 modulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="11825" checksum="09A5256257AFBD24" modified="2020-04-22" version="1">MKLQMHSIHFDADEKLVNFIQHKADKLDTFYDRIIDGEVFLRVEQDDANENKLIEIKLNIPGSQLFAKEKSRSFEAAADEAIEALRRQLKKHKEKLIANHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L1</accession>
    <name>A0A654E3L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018577">
        <property type="entry name" value="Restrct_endonuc_II_Bpu10I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09549">
        <property type="entry name" value="RE_Bpu10I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="268" mass="30719" checksum="D77DEE1191874976" modified="2020-04-22" version="1">MKKSEIDSEIADVYSRYLKFLEDISSFKIDSNENISKLVSSFNSYRNDTLLIIESRANSGQENIRSSMLEEFFCHLFSDLIEKSLETIPTNLFIGKANSYVDLTFSPSSFKDIFVSPNPYIHTKDQDFVLGVKLDLQITSTEKTYKESIIIPALAVECKTYIERNMLDSCAGTARRLKSAMPYCIYIVAAEYMKLKDEQPELSDINEIYILCKASNADRLKYKAEKKSPHPIDELLIIDFFDKVKGHLNSIWWSPDKALETGKVINRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q0</accession>
    <name>A0A654E3Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="26151" checksum="C478DF84F76DAC4E" modified="2020-04-22" version="1">MPFGKMHSGNPDIVELARLLGRTSGAVAYKLVNFASLDPSLQARGIKGADHTSKLDKEIWAEFYANWDQAVYESEVLLGKKKGILEASPIIESDFSELDGGEKERFVKTRINQSFFRKTILASYNNTCCITGINLPELLIAGHIVPWSIDEKNRLNPSNGLAMNGLHDKAFELGLISISPEYKILISPSLKKNKNQSIKKNFLAFEGKEIITPTKFLPDPSFLLYHNEKRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W5</accession>
    <name>A0A654E3W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="152" mass="17653" checksum="CDE0271476B68B28" modified="2020-04-22" version="1">MNLEIGKLGHTEKAPMDLLFKADPSIEMIEKYLYSGECYLAKMNDEVVGVFVLMPNNPQEMELKNISIVDQYQGQGIGKEIIKYVMRISKMEGYEYLVVKTADTSADTIKYYEKMKFEHYFVAKGHFLKYYNQPIIENGNQAIDQVAMRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X1</accession>
    <name>A0A654E3X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="542" mass="60728" checksum="3BDCD9DB409B0687" modified="2020-04-22" version="1">METPKNSKSAIRLPLYIALGIALGIFIGANMAEGNDPSDSLYESIYKFRQVITHIQNDYVDEVNTEELAETAITEMLEKLDPHSVYIPAKELEISQSQLEGNFEGIGIEFNIFKDTIHVVSPLSGGPSERLGIMPGDKIIKVDDKTVAGTGINNRGVIDLLRGERGSKVKVEILRKGNSDLLEYMIVRDVIPQYSVDVSYMVDDEIGYIKVSRFAATTFMEFKEAMNKLSQAGMQRLILDLTGNPGGYMDPAIKISDELLAGTQMIVYTKGKDPRHDAEYFSKTKGDFESGSVIVLIDEGSASASEIVSGALQDHDRALIVGRRSFGKGLVQMPIQLKDGSALRLTISRYYTPSGRSIQKPYDGSLEDYHLEFYERFQNGEIYSQDSIKFADSLTYQTDKGRTVYGGGGIMPDYFVPLDTSANSSYMTRLFNTNSIAEFSLIYADENRSRLEKMSLADFKSSFRMTDKIWADLQNTGTQNGVKFNSKEFEKSKQLLEIYTKAFIARNIWKNDGFYPIFNEQNEVFQKALTLIDEANKLAENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E429</accession>
    <name>A0A654E429_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="50645" checksum="8C26044CCC0AEF13" modified="2020-04-22" version="1">MGVRDLLFTPFYLLLISVGAFFLRPYFTNRQTRRYFLPALYLKIFGAVMVGFIFEFYYGYGGDTFNYYFKPGVIIANSFFESPMAWFRLVFGPTEYHPDTYQYASRIFTFGDAPTYFIARIVGFFGVVCGGSYYSIAIFFAVLSFSGVWALFNAFCTLYPALVKQLAVACLFIPSLWFWGSGILKDPITLSALGWIVYGVFGVVFQRRYSISMVLIFIVSFYILYTIKIYILMCLIPGIMVMVGFASMKRIDNWALKLLIVPFIVIIVIFGGFFSVQEISEDNQRYSLDAIAYTAEETAKWLEYVGEQQAGSVYTFGDYDFSTGGMIRKAPMAVFTGLFRPVIWEVRNPVMLLSALESLFMIVLLIRVIWKIGLSRFFSQIFSNPVVGFCMVFSLAFAFAIGISTYNFGSLVRYRIPLIPFFIIGLYLISEGQNFRKRTDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E451</accession>
    <name>A0A654E451_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024952087" evidence="1">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="419" mass="46836" checksum="C6EBBE203FD95DAF" modified="2020-04-22" version="1">MNFHKTGIIVFALLIGAGASAQFIASPYSNNGLGEVLFQGMPNNYGMGEVGIGSPTPWHINLQNPALLTHNTFSSFQVGLIGDFRNHESTVGKDKDSGASLRFMAMSFPVIRNRWTTSFALLPLSSVKYHTYSQDSIDTGVLGITQFQGDGGLSQLIWANGFRIYKSLALGVKASYVFGTIDRQSRVQIFSEDFSSNYAIAYLESTAYSDFNFSLGLSYRWILQEKKFLNFGATYDLSNTLEGTENQIFQRLRLTGTTVQTQIIKENIKTEFTLPKTFGLGVSYELLNTFQVGVDVKTQNWKSANEKTTAVSLRNTQNVAVGVSWTPDYQSVNSYLKRTTYRMGMNMKQLPYLVNNREINDFGINFGASFPVSGFSSLDAAFKFGTRGTTDSNLIKENYFQVVIGATINDRWFVKRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E468</accession>
    <name>A0A654E468_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative high light inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7529" checksum="D0FC919D82B421F3" modified="2020-04-22" version="1">MFYYFSRSLHVGAPYILKNLDSTTENLVRKGKNNWKNIILMIEIGLVIGFLAIVVLNYFFRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L7</accession>
    <name>A0A654E4L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="10685" checksum="39FCEFA55D2A344D" modified="2020-04-22" version="1">MTLSEATEKVKKLAANNGGKVKAKINFKFDEGLIHLDDTVSPTMVSNEELDASCTIKLSLENFDKMMHGNLNPMMAFMGGKMKIDGDKGVAMKLASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M8</accession>
    <name>A0A654E4M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpC/TSA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="20144" checksum="E10D44150B5F3F1C" modified="2020-04-22" version="1">MSLTLSSMMSLGTPAPDFRLPDVVSGKSVSLSEARGAKGTVIMFICAHCPYVIHIQEEIANIAHYYQDKGVDFVAISANDVIKYPGDSPKALKEQALSVGFTFPYLYDESQRVARAYKAECTPDFFVFDENNLCVYRGRMDEASPGNGKPVNGKDLRGALDALVLGDPISDDQHPSMGCNIKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P1</accession>
    <name>A0A654E4P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pruA</name>
        <name evidence="11" type="ORF">MARINOS108_60148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="10">
        <location>
            <begin position="56"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="543" mass="60106" checksum="10CB4E77FB4E5FBD" modified="2020-04-22" version="1">MSKGNYYIPEPSNEPVLTYAPGTPEREELKKAVKLARKEERDIPMYIGGKEVRTGNKIKMSPPYDHKHVLGHFHEGDASHVEAAIKAALDAKEAWENLAWEQRASIFLKAADLLAGPYRAKINAATMLAQSKNAYQAEIDAACEFIDFLRFNAAFMQEIYMDQPESSPGIWNRLEYRPLEGFVFAITPFNFTAIAGNLPASAALMGNTVVWKPNYSQVYSAQVIMEVFKEAGLPDGVINMIYVDGPVAGDVVFNHPDFAGLHFTGSTAVFKHLWKTIGQNIDKYRSYPRVVGETGGKDFVIAHKSADPQEVAAGLIRGAFEFQGQKCSAASRAYIPSNIWEAVKKQMAADLKEISMGSPEDFSNFVNAVIDKKSFDKIAGYIDRAKKDTDVEVLFGGNYDDSVGYFIEPTVLLAKDPKYTTMCEEIFGPVLTVYVYDPEQYEETLTLVDQTSPYALTGAVFSKDRYAIELATKKLRNAAGNFYINDKPTGAVVGQQPFGGARGSGTNDKAGAGINLLRWVSARTIKETLVPPKSYRYPFLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V0</accession>
    <name>A0A654E4V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar porter (SP) family MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="14"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="470" mass="51750" checksum="465515B316E4C630" modified="2020-04-22" version="1">MKVFKIMNARILYYAIVVGLAGFLFGFDTVVISGANLPIKELWNTSDWFHGTFIMSMALWGTVVGAIFGGYPTDLIGRRSTLYWVGVLYLTSALGSALATDPYLFSFFRFIGGVGVGISSIAAPTYTSEIAAPSSRGRLVALYQFNIVLGILVAFVSNYLLQGVGGANDWRWMLGVEAIPAAAYIIMVLGVPRSPRWVLIHKKDEPGALKILELNNSEAEARSIIASIKQDVKNNLNAHTSVFSVKYRWSLMLAFLLAAFNQLSGINFILYYAPEILVKAGFGSSDSLFSAIFIGVVNLLFTMLGVFLIDRSGRKMLMYIGSIGYIISLGMVGYAFYAELSEVFKLTFILTFIAAHAIGQGAVIWVFISEIFPNKVRAYGQAWGSGVHWLFAALITLFGSVLINSMNPWTVFWLFGSFMVLQLLFVIFMMPETKGASLEELQSRLGGMKTKKSQSTIQEVKENYVAEVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y7</accession>
    <name>A0A654E4Y7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3857 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3857" evidence="1">
        <location>
            <begin position="43"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="642" mass="72815" checksum="999C13A04CEEF268" modified="2020-04-22" version="1">MKFGKLDMQELTLKECSFYPEAKAMVIAEYGDLRFNYLNDNWTTKFTITRRIKIFTTEGKNQANVSIRLYDPVDGGIHERLSSVKAITHNLVDGRIEKTPLNQSEVFRTRLSDHRTEISFTLPNVQVGSVIDYEIILISNYLSVLFPWKFQKSIPTKVSEIRYVIPEYFNYITSQLGTSIELTKETNSVHESFKYKWESEPGIGGNKAVAIGAENSVSKEQRFVARNILPLEDEPNINNKPDLPARLEFQLVSSQMPNSAVKFYADNYESFTKDILTWESFGKTLDQGAFASPAIKELRADSVSDLASAIYHWIQNHFSFTNEYGVTNNKAGKIAFNEGSGNVPAINLTLIAALREAGINAYPIILSTRGHGIPHPVYPNYEDFNYVIVGVKTEAGLILADATTKLSFGTIPERCLNGKGWLVDNEFGQWVDLKKEAHYSSEVSINMTLEETQITSELHITHKNYAGVTTWEQVDSIGATNFIQEIDQKLSDWDIENFNIKSGTKESKEHFEFEITASRAINANKRIYISPFILGMPLENPFRRPERVAPIDFPYGFEYRVIAQIKIPDGYSAILPESGVFKLQSNDGSFIYSTNQVGNTINLVGIFKISKTEFNPNEYQNLKQFYQLVTDKNQELIVLNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E509</accession>
    <name>A0A654E509_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="29660" checksum="C99432EF844619F3" modified="2020-04-22" version="1">MNWPFREELISTEISDEGGSKYLTLRTETLALSYVQAYESDSMVSFAKIAGGLWLIFYLLHPAEGQGLIGLKSGFNLAAVSDGGEPSRLGPGYDLRLFTSQGIFRGEVDIRYDLGYSVVNISQKVAREDMRHTYELQLNYLAHSLTIGKKIGSLGARLGLEHAFLVSGSSVFKRDSYVIRNEQLDGYNRHNWSALMTVFYHHERWLFELAYYHGFRDLISPGTHPLSAFQGLDELHRLEFSVGFVMFKKSVDEHQTSLKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E518</accession>
    <name>A0A654E518_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/arabinose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="389" mass="42676" checksum="8528DAE493FF4FE1" modified="2020-04-22" version="1">MTRLIIILLSIALLSCTKTPESDSNTEKSTSADTTLLDMTDLQLDSLVLPDGFSIALYGRVENARSMAISPSGVLYVGNRGGDKVYALKDNDGDFKADEIYVLATDMRMPNGVAFKDGDLYVAEVSKLWKFPAIESNLAAPVKELIYDDYPTDGHHGWKYIAFGPDDKLYVPVGAPCNICESKDEIYASITRMNADGSDREVYVSGVRNTVGFAWHPETGDLYFTDNGRDMLGDDIPPCELNRATEKGQHFGYPYCHGGDLKDPEFGDKRSCDEFVAPVQKLGAHVAPLGMKFNTGSMFPSQYANLAFIAEHGSWNRSPEAGHSGHKITTVKIEDGQGVAYEDFITGFLNKETNTAWGRPVDVLFLKDGSMLISDDLTGSIYRVTYTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Z6</accession>
    <name>A0A654E5Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062694" evidence="1">
        <location>
            <begin position="19"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="377"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="524" mass="59070" checksum="9DB3E7F4344426EE" modified="2020-04-22" version="1">MRYPFALLFVFITGLVFAQTPAPERTEGDGPYDRLIIRGATLINGNGAPPMGPVDIVITKNKISQISIVGYPGVSIDNSKRPRSGENDHEIDAEGMYVLPGFIDMHGHIGSISEIPAEYVFKLWMAHGITTIREPGSFQGRDWTLDHKKRSSKNEITAPRIISYTGFGMGSDGINTEEEARKWVRANAEAGSDGIKFFGARPEIMKAALEENKKLGLGAACHHAQTNVAWLNVLNSSEWGLTTMEHWYGLPEAMFHDRTVQHYPADYNYQNEQQRFEEAGKLWEQAAAPGSEKWNEVMNTLLARDFTLDPTFNIYEANRDLMRARNADWHKDYTLPVQWDFYAPSKVSHGSYWHAWGTEQEVAWKKNYLLWMTFVNEYKNRGGRVTTGSDSGYIYQLYGFAYIRELELLREAGFHPLEVIRSATLMGAEALGLQNQIGTIEVGKLADLVLVEENPLADLKVLYGTGAIRLTEENEIIRAGGVKYTIKDGIVYDAKELLKDVREMVKKAKLTDGEITQPGYPNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E644</accession>
    <name>A0A654E644_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="32129" checksum="E89DBAF948F7467E" modified="2020-04-22" version="1">MAVIPELLRYVKISFFHPQPKLKRKEKSGVYVSLTTTPSRISKLRDTLISLSDQSVLPEEIIINIPKISKGGIRYEIPDFINHMKLVHINFIEEDLGPASKSLPTLKIPSIPSDALIIVLDDDQVYPKKLIENYLHHARTLPNHALTLCGWRIPKSLEHSDKKILRGAGLKIVKPKPNISGNTSVEIIQGASSYAIRKSFFTNEVFDYVHAPKGAFFADDIWLSGHLAKKKIPRTLVMGNFAYCRMESYKHLKTKGLRDTANADNSNNDALYRYFEGDWKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E656</accession>
    <name>A0A654E656_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032526">
        <property type="entry name" value="DUF4960"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032186">
        <property type="entry name" value="DUF5018"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16324">
        <property type="entry name" value="DUF4960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16410">
        <property type="entry name" value="DUF5018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024913980" evidence="1">
        <location>
            <begin position="28"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5018" evidence="3">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4960" evidence="2">
        <location>
            <begin position="148"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="425" mass="44838" checksum="19FABCEC9176A6FA" modified="2020-04-22" version="1">MKMMKTNMKFLVALLLAAATMMVISCKDEEVTPGDAFMISFVVDDISGSIDEADKTVTLELPAAADITAVTPVVSVSEGASVSPESGTAVDFTEPVVYTVTDKSGSISVAYTVSISQADLRKIAFVGVAAENTAASWDALDGSDFDLNDDQEAATWFAESMPSSTTEVAYHSIEDVAGGADLSGYHAVWIQFDGGWWGGEVAQFPNNSNHCLLMESGIGFDTPCETLSADFVAAIKAYYEAGGNLFLGNFAGAMVDEIGAVASADLAPNNSFGGLAVDEGATDGAWGVRWAGETSSPLFNGIVTSTDEGCAAPFFITLESGTQKKNRSNQYNLNFGPWAPNGDTDPLDDRRAAFEEMTGASILVENCGQNEPQMVEWTASGNKGTVIAILGGTYDWYVGDVSNNDNIPSLTKNSLLYLADKALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6C5</accession>
    <name>A0A654E6C5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_11487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="132"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="423" mass="47136" checksum="F1DA5944D20352AC" modified="2020-04-22" version="1">MIKANNPQLKSWIPTKADSDFPIQNLPFGIFKNGDDHTGAASAIGDFVIDLKTLYDLGYFDGLSLPKEVFSKNTLNEFIGLGKETTRKVRERLSDLLEVSNTELQHNEAVRSSVFIPMDQVQMLLPVHIGDYTDFYSSEQHAYNVGCMFRNPDNALMPNWKHIPVGYHGRASSIAVSGTDFHRPKGQTIAPDAQAPAFGPTKRLDFELEMGFITGKANPLGASIPVAEADEYIFGFVLFNDWSARDVQKWEYVPLGPFLAKNFFSSVSPWIVTMDALEPFQVPGPVQDPQVLPYLELADRKNFDVNLKVFIQPEGSEEKQVSHSNFKHMYWNVNQQLAHHTANGCNINVGDLYASGTISGPTPEAYGSMLELAWMGTKPIAMPDGTERKFIHDGDTVIMRGYAEKDGVRIGFGEVRNKVLPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6J3</accession>
    <name>A0A654E6J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024838898" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="405"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1213" mass="132537" checksum="20C2C9B8DBCAC689" modified="2020-04-22" version="1">MKSILSILAILLTSVTLSAQMVTLSPANPSGDDEITITFDATQGNGELVGAAKVYLHSGVVLDAPDGTAWNNAIGNWGMDDGVGQMTKVAGATDKWEIKLTPTARQYYGVDASATIFRLAMVFRNADGTKKGTASPGTYDWGFVAGNQDIYVNLDAGFYVSILNPADDEVYLTSGEALKIEAEASAEVTAMALAIDEGQGFVEVASVSSGTSITYDYSPTQSATVSIKVSATISGQSVENQMTVNILLRQSTPVAALPAGAKKGINYVDGDATSAILVLEAPGKEFAYVVGDFNNWTPSDNYLMNKTADGELFWYELTGLTAGEEYVFQYWVDGTIKIGDPYADKVADPWNDQHIPAALYPDPTGYDKTDYQMATILQTGQEAYVWAETESTWSRPAKQDLVVYELLVRDFLGSHSYQDLSDTLGYLKRIGVNAIELMPIMEFEGNESWGYNPVYYFAPDKYYGTKNDLKHFIETAHQQGFAVILDMVLNHAYGQCPLVKLYWDETLNAPATNSPWFNQVPKHPFNVGYDFNHASTYTQDFMDSVNNYWINEYHFDGYRFDLSKGFTQNNTGDDVGAWGQYDPGRISILKRMNNEIKAVDASSYVILEHFADAQEETELGNAGMLLWRNVHGDFDSALKGNARGISGAASSIHVSYMESHDEERQMVGMLSGGLQAGNYDVKNTAVALERAKMGAAFLMLQKGPKMMWQFGELGYDVSINFNGRVGNKPLPWGSGNLGLYEDPLRQHLYDAYAAINHLRVTYPSVFNVGDVEASLGGKLKSIAIQHGQLDVVVIGNFGVEEGELTYEFPSTGAWFDYFGGDEFSVTSAAATQTLKPGEFYIYTNKRVSEGFPGVVEIYENPVTVSPSSFGLDDEITIIFDATKASKDGTAGLVGASKVFMNAGLVVNDPKGTDLSHKVEDGSGEMTKVEGQDNQWQITLTPRAYFGLSQEATAFRMGMHFRDEAGENIGKGFRNELVFLEIQSDVALVSFDPAEFFTNQEVSLIFDASLGDQGLLNATKIYAHSGAVLTPGDNPSFGSNVVGNWGADDGVGQMTKIDGTSKWELKYTPGMRDYYGLAASDSVYWISVVFRSADGSVKGSGPAGDFKGGFIAANGDIYLKVTPPQKEETLGVKKENLGKVRLFPNPTTGQFRMDGEVSTPYNLFLFDMSGRMLSSLLIQDSSKPIDLSYLREGQYLLQVVSADQTRSLRLVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7R6</accession>
    <name>A0A654E7R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="24106" checksum="FF34BD74DE325DC3" modified="2020-04-22" version="1">MENPYLDSSVDRGIFDKKYPSLSEATVDDEVVWEKFKKGDKAALTFIYRNYANPLYNYGCQLTSKEIVKDAIHDLFIEIINNKERLGNTNSIKYYLFKSLRNKLVKVLTKMTKEQSGDMGDAYPFAISLSPELVLINQQIDEEKRSMIAAKLNELPPLQKEALLLFYYEGLKYDQIASLLGMKVKSARALVYRGIDSMSKLLIPVRKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7S8</accession>
    <name>A0A654E7S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024855684" evidence="5">
        <location>
            <begin position="22"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="114"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="463"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="995" mass="109301" checksum="D354586B07BECF00" modified="2020-04-22" version="1">MRKRRLLLLALLIGYASTSWSQTRVSGLVTDDQNAPIPGVNILVQGASTGTVTDFDGNYALTVPGPDAVLVFSSIGFHQQNVTVGTKSTINISMVPDITSLEEVVVIGYGQVEKKDVTGAIASVESKDIVRANPVQAAKAIQGQAAGVIVSKQSSRPGAGYSINIRGLSSIDYSNEPLVVIDGVMGGDINALNPADIESMDILKDASSTAIYGSRGANGVIIISTKRGSTGKPVVSYSGYAGVKVPAHLPDMMNAQQFYKASVTDNELNGGTSRPFTSTEMDLVESGRSTDWLDKISDPAMQTNHSISVGGGSGSTNYHFSAGYLNEGGNLKNTKFQRYNIKGSMDSKVNDFLKVGFTANYSLAKQEMGSNEALRSAYRARPTGVAHYDEVLNPDENQELEWNGYAAWMGINDKQVLNPLIEIDPYNFQDETRSNTFFGNAYIELTPVDGLSIKSSLSASVDNSRFGQFRGTMTKDRKTTLLPRSFRQTDDISNYTLDNIITYNKKVGEHDFTLTGVQSSFQERNEEMDSYVDELPYNSLWYAYGTGRPVELDTRLTERSLLSYMGRLIYGFKSKYILTLTSRWDGASQLSEGNKWDFFPSAAVAWRLGEEDFINSIEAISDMKLRVSYGLVGNSSVSPYSTQARLVNTPYDFDGSEAYGFAPSNLADRNLKWEKSKELNIGLDMGFIKNRIGASLEVYNRKTVDLIYNEQIPTSSGFSSVTTNVGEVANRGVELSLNTVNVVNSKFKWTTSVNFARNVNEILSIGNDGIQADIATGLFVGHPLQSHYDYEFDGIWQLDEEEAASEYNQVPGSVKVVDQNNDGQISSNEGEDDRKVIGSEQPDWTMGMTNKFTYGNFDLSFLIYTSQGATYRNSMLSGTMGEVGAGRYNALNLNYWTINNPSNEYYGPGIANNPYRGAIFYQDASFVRISDITLGYTLPSTGLDKFGFSNFRMYVQVSNPFVFHDFDGMDPEFNSSTYNDGIPSATYLFGLNVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E818</accession>
    <name>A0A654E818_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="242" mass="28368" checksum="C11612A9E8A8FCE7" modified="2020-04-22" version="1">MQRKLVVAILGKLHTERELINADKTQIYRLAKLASTDEATFRAVCDHVNFFVTFNDRQTLNTTYANHTLENWMELDREMIIALGFKRIRQISDPEVMSRAIREVQSFERAYPDGQRFCSYLQRLYFRGGYQWISTHKTVFDHHTYLNCGYNIQTLGKPGALIRNLLDEVFVEKNAWERFESLGKREREVLALVARGYTSKELSELLFLSEHTVRTHRKNILAKLEITSNAELVRFAQAFELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9D3</accession>
    <name>A0A654E9D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="38612" checksum="696E8C2E4C896978" modified="2020-04-22" version="1">MGVLILWGCEEPYDFEEDKDIERPIIITGYIDQSSGPYFVKVSQASATGSLPANVLAACVILYDESGTSEEFEEVGDGVYRCPGNTVHGEPGGSYHIEVKLSTGHVFRSVPETMPALQASDSLNWKETLDVRTASTGLDFKVPVVSIDMTTSIPQTSEPLYFNWVGAESFSIIPTDFPDPFGSIPPPCYVTRYFGSEKINLFSNLQNKAPSYTFEGFWIRDIDDSFLTKHIFTVYQYGISKGYYSYLQSVKVLVENNGSLFDSPPGRAVGNIYPVEGDALVQGYFHASVVDTTRMAVFPNELISFIIDDCEYTIGKPFSEYDAHCLNCLNYPGSTYERPEYWTKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9X4</accession>
    <name>A0A654E9X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="31316" checksum="1ED5E4B155EEC62A" modified="2020-04-22" version="1">MDTEQEIYFHVGLGKVASTYLQQAVFPRLQGVHYISTHSYRKSKAIIPRLSAEKVLVSREFDRQLEEEVRWFTSTYPQARVIILLRRHADWIASQYKRHVKNGWFGSFEAFLDLENDAGYWKQKDLCYAPMLRVISECCIDPPLVLFYDDLKTNPEAFLNSLAGFMGVPAPQVTDKIIHPSFSEKQLKVLRTFCRKVVRRVPVNYQHKWKHWLLYRPVWAFYHLVLYGAALLPDRWVGEEPLIDPALLEEVNRKFEVDWKAVREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9Y4</accession>
    <name>A0A654E9Y4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter NhaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaC</name>
        <name evidence="8" type="ORF">MARINOS108_120291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004770">
        <property type="entry name" value="Na/H_antiport_NhaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00931">
        <property type="entry name" value="antiport_nhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="164"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="478" mass="50435" checksum="BA66DB5DBD83E641" modified="2020-04-22" version="1">MAIKRDPTLLESFIPVLFLIILLSFNVGIFGDAALDGSNQIVLILSAGVAAIVAIRLGYRWDEIQDGIVRSISSAMTSLLILLLIGSLAGTWLLSGIVPAMIYYGLQILNPTIFLVAACIVCSIVSVATGSSWTTAATVGIALIGIGKALGISEGMVAGAILSGAYFGDKMSPLSDTTNLAPAMAGTDLFTHIRYMAITTVPSISIALTIFLVLGFTNETSTSVVDTQAILNAIDDKFYISGWLFIVPVVVVVLIVRKMPAIPALLIGTLLGSVFALFFQPQLVAEVGEGFTASGMFIGTMKSLYGDISIATSNDMVNELLSSGGMAGMLGTIWLILSAMIFGGVMESSGMLKRIAKALISLVNSTGALITATVGTCVFFNVTASDQYLAIVVPGRMYADIYKRKGLAPENLSRTLEDSGTVTSVLIPWNTCGAYHSSVLGVSTLVYAPFCFFNIISPFMSILVGYLGYKIKKLNPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAL0</accession>
    <name>A0A654EAL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4266" checksum="DE71876A6685C37E" modified="2020-04-22" version="1">MVAIATHRDSQEDQEEEEVEPMKALRGDVIANNLINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBU5</accession>
    <name>A0A654EBU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014985">
        <property type="entry name" value="WbqC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08889">
        <property type="entry name" value="WbqC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="212" mass="24883" checksum="F84F47318B2F3E3B" modified="2020-04-22" version="1">MAELIIEPHYLGSLEYFTQLINSERVFLEVHQHFSKQTFKNRCYLLSTRGAMPLTVPGKFTNRTPFKEVQIAHDQSWKRAHWGAFYSAYGKAPFFEFLADHFKDIWDRKHRFLLDLNFEMMTLCLKILQIDIPIEITESYQKKINTPLIDLREHIVPKKPFEERHLYIPSPYTQIFGSKFVPNLSIIDLLVSEGSNALEVLKKSSYPTGEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDZ7</accession>
    <name>A0A654EDZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="99" mass="11523" checksum="82B9A9930C5B4A79" modified="2020-04-22" version="1">MTNQNIKEVVVYTLNEKVDPANAFAFVREILAGYHGVVSIETEQMLNDPLTYMDIIVWENAKQAQEAQQNFEKHPRASEFGHYFKETKFFAHFQPLQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFG4</accession>
    <name>A0A654EFG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="290"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="577" mass="65534" checksum="5C8200BD861673A8" modified="2020-04-22" version="1">MKLIQRYLLILLVAITGISCSDFLEVSPQGVIGDEALNSPENIDGLVIAAYAMLGNDHYTVPNMLWPWGDLRSGDAYKGGDGPADISIYHAMEVFSTIQPDMSAYAPSVLGDLDNKKWERQYTAISRVNNALRRLQDVDETAYPKKSQRIAEMRFLRGHYYFDLKILFKHIPWIDEQASVEEIEAISNTVYTDQELWDLVAAEFRAAASGLPESQTDAGRPNKFTAKAYLAKVLLYQAYEQNEDHQVVAVNAEKLEEVVTLVDEVIGSGQYSLESDFANPFLWEFENGTESVWAIQRSHDDGTTTGNIDFSSMLNNPMSTELGCCWFHIPSQNLVNSFKTDESGLPMFDAFNENDLDLSSETVDPRLDHTVAQPEKPWKYETSIIYTEDEWARQPGIYGPYSSLKENVSPNCECFERIPPFMSSSKNTILIRFADVLLWKAEALIELGRQGEALPIINQIRQRAINSTELLQYANGAPLSNYNVALYDGSAWTQTFARQALRWERRLELAMEGHRFFDLVRWGVAAQEINEYFSAEKSKREYLQSAQFEAGKHEYLPIPQQQINLSNGRYLQNKGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSM3</accession>
    <name>A0A654DSM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="158"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="31365" checksum="3D0E8151B3FC9472" modified="2020-04-22" version="1">MNYETFAPHPDLDAIVKCHWILEVPDDMEAPKQRVIADGCIEMCFILGDDVRRFTSETDYIIQPRAMVFGQITKPCYVQPTGYVNTFAVRFYPYGFANFITRPIRELADKETPLTSLFEEQSVRVLEQKIIEAPSTRSRIELVENFLLGKLKDQSIIENIVKSTIDALSQTKGKMSINSILKDDLSKRRNLERKFSKQVGISPKQLGKIIRLQAALKLILNNKGEKLTQIAYESEYYDQAHFIKDFKEFTGTNPKEYLSDDQMILSSLIYSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT02</accession>
    <name>A0A654DT02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="425" mass="48848" checksum="337C7CFD67C17FDD" modified="2020-04-22" version="1">MRNIYQRGFLAGALIVLFSTHTFGQKNWMDGWIVKKGGEKEEVQINYENWDKSPDRVSVKVETGTTTYGVDDISEFFVNNEYYKSYSGTIVNLPIKDEHLSYDPEIKYSEVRAFLRYIYKDDLSLLVLKDVKSKSHFFVQRANEKPAELEFYKFKVDEPMPNTILKNERYKLQMSFFFESCSNQDLLRRAQYDLRSISRSFLAYYECSNRVPTYQIVKEKSESDVGLSIGLTNTMVKYDGSFAGGNSIQRGDFENTSSVYFGLFGRFVVPRTQGKFSFDAEMGVQKLSLRGDYYQQAETYTDEIEYTVDANYLRVALGVGLKVASFSEKSELLIGAGVLTNFGKTSSKEDLKRYDSNGTLTVDKKEDVFESDDIRNQEQGFYTKLKYHYGSFGAFGRVDFGNGYSNLSTLSIKSRRLVFGLEYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTD6</accession>
    <name>A0A654DTD6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033395">
        <property type="entry name" value="DUF5106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17127">
        <property type="entry name" value="DUF5106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="332"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="471" mass="55067" checksum="DB8F8A2CFEBE06EB" modified="2020-04-22" version="1">MAACLHYFKNNLLAMRKIVLMILWIAPYLSQGQSAEINFRIKDFKDSIAYIGYHFGHQKYLMDTLPVSEDRFSMKVNQPKQGIYFIYTPSYYFEFVMDGKSFGLETSVSGGYDQLKVSGSKENELFRSFQVEIGGLQKKQRSFVERLKEATGEDSVRIMKDIREVNVQMEDVRKKLISENDQSFVAAFLRLMRDPDVPSLDSISDESQRKMQRYTYYKSHFFEEGQLQDGRLLRTPLLYPKVTKYFDEVVIQQPDSLIRELDWFFGQIKHDEESFRYWLVTLFKKYAESKVMGMDAVMVHMIENFYLTGRASWISEEYEKTLREEVAYVKPNLIGKQAPPINAVDTLMQAFSFSDIQTGYTLLFIYDPDCGHCKKSVKKLEEVDGRMAELDITVVALCTTTDVSRWKKFVASHNPMWVHLIDPTGKSYFRVSYDVRSTPRIYLLDADKRILAKRLEIDQFLDVVERMKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTG5</accession>
    <name>A0A654DTG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23725" checksum="D4E9691B45BCF27B" modified="2020-04-22" version="1">MMILMRMEVPGILMFSLGFGLKFFHIPHNAVLMLLGLLCLLLSLMGALMGGEGAQKRPVTRLSVILSLAALLCVIKFFPVNDYMLLLAALAFLWTVYLLVGKKVKLNAIHYVSLLALAFTVFFRFGVDRSDRYFILNLKYSVEQSTDFITWDKYSWMLYLDERADESLQASEKALSIAQRVDADKYWLDLIDGHGVAIRDKTWERYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTI0</accession>
    <name>A0A654DTI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="104" mass="11603" checksum="1C351B31648B88F7" modified="2020-04-22" version="1">MAVTRLERKGKRNKSRAKNRVSKIKQLNAMPTIKNVDIEEIKKSFETAPKPAKKAEAKKEEAPEVKAEAPAKEKKAAVPKAEAKEAKPKKAPAKKKDTKDKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTI6</accession>
    <name>A0A654DTI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin OsmC</fullName>
            <ecNumber evidence="2">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">osmC</name>
        <name evidence="2" type="ORF">MARINOS108_10392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019904">
        <property type="entry name" value="Peroxiredoxin_OsmC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03562">
        <property type="entry name" value="osmo_induc_OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="14868" checksum="9AD1E219EEE65171" modified="2020-04-22" version="1">MKFTRNASANWKGTGKDGKGTISTESTTLKDTQYSFKTRFEDGVGTNPEELIGAAHAGCFTMQLSFLLSEAGFPPDDLDTAAKITFEDGAITMSHLELKGKVAKISAAQFQEIAEKAKEICPISKLLNTKITLSATLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTM4</accession>
    <name>A0A654DTM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="19579" checksum="8BA8BD54C303E073" modified="2020-04-22" version="1">MEDEYLPFFITEDLYLLDEIIPESVKETPPAPVVEEKVETPAAVVEEKVETPATVVEEPPAAIVPPTVHDLAIWSPPLTAQDKELLVKILAAINEDFEKANLMEGINAYEPHYHKLLCFGYQKELELKLGTAVASYQPTKVSDRQILVSAAPADLHADKNEKGRLWTALQEMFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTP8</accession>
    <name>A0A654DTP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="167" mass="19066" checksum="613CB14AAB62E422" modified="2020-04-22" version="1">MTRTIKFKTILPYPPELVWRALTEPQQLGNWFMENDIKPLPGQYFTFRMKPQKGWDGITHCQVLSVELFKHISYTYLGEATGEKTLACSGIHSDTADKMTKGIFAKLDTILSFKLEPTCGGTILYLEHSGYKGLKLVIISLVMQMGWKKQLNKKLPKVLERLSDPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTU0</accession>
    <name>A0A654DTU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">K(+)/H(+) antiporter NhaP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP</name>
        <name evidence="8" type="ORF">MARINOS108_10448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="404"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="489" mass="53529" checksum="7B763D64740112CC" modified="2020-04-22" version="1">MNITIENIILIGSVLLLISIIAGKTSYRFGIPTLLLFLTIGMLAGSDGIGGIYFDNPQIAQFIGVVSLNFILFSGGLDTSWQSVKPVLKEGIALSTLGVLLTAIGLGYFVYLITDFSLYESLLLGAIVSSTDAAAVFSILRGRNLALKKNLRPTLELESGSNDPMAYVLTIAFLSLVQEPEQSIFSIIPLLFLQMSIGGVAGFLFGKLSKIVINKIKLDYEGLYPVLTIALMFITFSATDAIGGNGFLAIYICSVYLGNQNLIHKKTIMRMFDGLAWLMQIVLFLTLGLLVFPSQIIPFIGVGLLISIFLILVARPLAVFIALIPFKMRLKRRFYISWVGLRGAVPIVFATYPLLAGIDKSHAIFNIVFFVSISSVLVQGTTLSIVAKWLNVGLPEKAKPLSPTDQLMVEHPKTLMKEIVVEENSTAIGLKIVDLKFPKNAIIAMIEREGNYLTPNGSTELMARDKLVVLTDKKDVLNEVYTSLRMDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTY8</accession>
    <name>A0A654DTY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="106" mass="12080" checksum="9E599DB6B6D6020D" modified="2020-04-22" version="1">MAALKTYTLDEVTDKFIGKRGTAKREAFEYELKLDLLGEAIKRARKERNLTQEQLGELVGVKKAQISKLENSLTDARFETIIKVFKALNAKINFNVELLNEHVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU21</accession>
    <name>A0A654DU21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024975258" evidence="1">
        <location>
            <begin position="25"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="129"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="801" mass="89842" checksum="C80E62CF1D1F5224" modified="2020-04-22" version="1">MMKKNRLSAILGLLCLVSSAIGSAQPQHTISGYIKDASNGEALIGATAYVSEIANGAVSNAYGFYALTLPKGTYHVSFRYMGYTDIHKEIELTGDLRLNLELHAGEAQLEAVVVTGEALDENVQSIEMSTAVMDIKSIEKMPAFAGEVDIIKSIQLLPGVSTVGEGASGFNVRGGSVGQNLVLLDEAPVYQSSHMFGFFSVFNPDAVKDVKLYKGGIPAKYGGRLSSILDIRMKEGNNKTYDVTGGIGTVFSRLAVEGPLKKDKSSFIIAARRSYADVVARTFTDALEDDTGLYFYDLTAKTNFNINEKNRVYVSGYFGRDVFRLDEFQGFDWGNRTATVRWNHLYGSKLFSNITAFYSNYDYGFQLGESDLDKYDWKSEISTYNFKPEFTWFINAGNELTFGGEAILYQFEPANAITVSDGVTADISLDHRKALETSLYLGNDQQLTDRLTLQYGLRFSRFDYMGGTAYQYGDTLPGMERPLIAVEEKSDWESIKTFGNLEPRASFRYQLSKVTSVKGSYNRMNQYIHLISNTTAATPIDIWQPSSNNTRPQQGDQVALGYFRNFQSNTYETSAEVYYKWSHNQVDYIDGADLFINEFLESQLLSGRGRAYGLELYAKKNTGKLTGWVSYTLGKSELKVDGINYGYRKDRVGSWYPTKFDQRHNLKVAAFYDLSKKVSFSSNFSFISGTPTTFPTDRIMIQEYVIPYIDGNKRNNFRIPAYHRLDLAMTINNVWRGKKGRSGEDNLVVSVYNVYARKNPFSIYFSQGRERQSAEQPIATSANQLSMLGTLIPAISYNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU67</accession>
    <name>A0A654DU67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4147" checksum="1A48FB614A429ABD" modified="2020-04-22" version="1">MKGRFRISVVAADLWGVTADVLPMLCYARLRIPGSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUB7</accession>
    <name>A0A654DUB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="119"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="789" mass="89815" checksum="EE9E9D7A1864EE7F" modified="2020-04-22" version="1">MHIKPVLTFLLMLLGVQLMAQSVLISGKILDENGEEVPGVSILLKGTSQGAISDIEGAFELRVPTGNVTLQFTHVQYEPVEVAYTLEQDQTVEILLKEGTTRLQDVQIEDKGLRESEVVNVQKVDAKSAKSLPSTFGDFNKVLVTLPGVSGNNELSSAYSVRGGNFDENLVYVNDMPVYRPFLSNAGRQEGLSFVNPDMVQDIEFYAGGWEPKYGDKLSSSLNIEYKEPDSIESAVTIGLLGGTAYAGGKTNQMSYLIGARHRDSRYLLNTLETKGQYFPTYTDIQSLFTFDLSGNKSQYINKTKLNILLSYGRNRYLTEPVSQTTDFGSVQQNFRLQTAFIGREIMRYDTYQSGFRLTHRFNERLRTHFIGSSMFTSEKEQFDVEGAYRLCDVNNNPNSSSFDECVVVRGIGTNYDYGRNDLEASIQTLESRWEYLLNVNHVLEGGAGVTFQQINDHINEYSFIDSSDYVHLTNSVFNYINLSTRQYFAYVQNTFLWNDSVHAISSGVRATYWDYNGQILISPRVSYRWAPKWANFTTFKVATGLYQQPPFYRELRGFDGELRSNVYAQKSIHLIAGFTRLFYMWGRPFLFTTDVYHKQLFDIIPYDIDNVRLRYYSDKTGTAFARGLDFRINGEFVKGTQSWFSLGFLQTQENIEDDGQGFIRRPSDQRINLAAYFEDHMPGDPTLRVYLNLVFGSGYPFGPPNREDLRNAFSGDEYYRADLGLSKQFDLSINNFFNKLWVRLEVLNAFAADNTLSYTWIEDVNGAQFAIPNSLSARFLNIKLTAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL7</accession>
    <name>A0A654DUL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase, large subunit</fullName>
            <ecNumber evidence="16">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gltB</name>
        <name evidence="16" type="ORF">MARINOS108_10344</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="16"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="16"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD10984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1492" mass="165327" checksum="4795CC2C145EAE0A" modified="2020-04-22" version="1">MVNKGLYTKELEHDSCGVGCVADINNRESHKNVKDALTMLKNMEHRGATGSDENTGDGAGILVQIPHAFFKKELENFGITLPSKGSYGVGMIFFPKNYQVREKCRQVFNKCLKDLGLNLIGYRLVPVDSQVPGHESKAAEPYVEQIFIGINEKLTEEELERKLFVLSNYATHEIKNQVEGQNGDFYVCSLSAHTVIYKGQLKTDQLEDYYHDLTNKDFKSVFAIVHSRFSTNTFPNWKLAQPFRYLAHNGEINTIRGNVNKMKSKEANMSSPLFTEKELQWLLPVTDPANSDSANLDALIELLVLGGRSLPHVMMMLVPEAWQDNSQMEVMKKAFYKYHASIMEPWDGPAALFFTNGKQLGATLDRNGLRPVRYCVTKDNRLIMASETGAIPVKPENVLENGRLQPGKMLWLDLPNKKLFYDEEIKNEVVKDKPYFDWIKKERIKLRLLPDPEIKEEKIEKELLRKQLKAYGYTQEDVKLTVGPLAELGKEPLGSMGADAPLAVLSRQSQHISNYFKQFFAQVSNPPIDPIRERLVMSLYTRVGESLNILDESALHTKQIHISQPVLSRADFQKLISQKEIGFDYGSIDGTYDPSEINLKEALDRVCAEAQAEVEKGKKILVLSNRNISETRVPIPSLLTIGAVHQHLVKENIRTKTGLIAEAGDIWETHHFATAVGYGVSAVYPFKAYDCIADLYADGKLDQGTSLNTYYENFAHGIGSGLLKILSKMGISTLQSYQSAQIFECVGLGSEVVNKCFKGTVSRLDGLTFEDLEKECLIKHASGFDTDNKLLEVGGYFQWKRNGEAHLLNPETIHLLQKSTSLGDYELFKKYAASVHNYQDSTITLRSLFDFKKRTSVPLEEVEPASSIMKRFATGAMSFGSISHEAHSTLAIAMNRIGGKSNSGEGGEDEIRFAKKPNGDWERSSIKQVASGRFGVTSNYLKEATELQIKIAQGAKPGEGGQLPGHKVDEWIAKVRHSTPGVGLISPPPHHDIYSIEDLKQLIYDLKNANRHARINVKLVSEAGVGTIASGVAKAKADVILISGADGGTGASPLSSIRHAGLPWEIGLAEAHQTLLRNNLRSRVVLQTDGKLMTGRDVAIAALLGAEEFGFSTTALIVEGCIMMRKCHLNTCPVGIATQKPELRKLFTGNPDHVVNFFTFITEQLREVMAELGFRTINEMVGQSNVLKVRSDLDHWKLKNIDFSPILHQESVPASFGKHHQIDQDHGLEKVLDRKLIRDYLNKGENNKTYKIINIDRSVGAMLSHEVSKAYGSAGLKMSPIKIGFTGSAGQSFGAFLAPGIEFCLEGESNDYLGKGLSGGKIVVKVPQKATFKPEKNIIIGNVAFYGATSGKAYIHGNAGERFCVRNSGVEAVVEGVGDHGCEYMTGGKVIILGETGKNFAAGMSGGIAYVLDTDETFRDKVNMEMVGLEQPGSDDLAYLKEEIGAHVTNTGSQHAANILDDWDHMQQYFVKVMPHDLKRVLEENKIQEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS9</accession>
    <name>A0A654DUS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent RNA helicase RhlE</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rhlE</name>
        <name evidence="9" type="ORF">MARINOS108_10756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="218"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="413" mass="46610" checksum="75D6468297644CDA" modified="2020-04-22" version="1">MKFEDYRIGDALKRSIKELGYKKPTDIQFRTIPAVLKGEDVLAIAQTGTGKTAAFAIPVISMIDERKSSKRSERVSCLVMAPTHELALQITSAFDTLGKFTKVKTLCVHGGVEQEPQIAKLGKGVDVVVATPGRMFDLVSQGALVLKDVDTLILDEADHMLDLGFIKDIRDLMKHLPKKRQTLFFSATINPEIKKLAYSLVTNAIRIQVSPKDPVAKNIEHAVGFIEMDDKRFFLEGFINNHPESKMLVFVRTKVRAERVKKALERVGLESDTIHSDKEQKERDQTMKKFRSGELKVLLATDISARGIDIPNVEFVVNYDLPESSENYVHRVGRTGRGTQKGQAISFCSAEEKALLKEIEENLGKPIQRIEITKGEYQNTMDFSKENAYDVQSLIREAEAFEQNRKKKKKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU7</accession>
    <name>A0A654DUU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025412">
        <property type="entry name" value="DUF4304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14137">
        <property type="entry name" value="DUF4304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24476" checksum="76FE05DC805CCB87" modified="2020-04-22" version="1">MLQCFLQLRRDLTVSSAAEKVLSYLPNSARGIFSLQNALPSANFGSTGRLHYFSAVHKVRAHASYMGVMMHRGQLMTNEEFKNLINQLLSPLGLKRRGNYWRTETEHLEKICNLQKCNFSNLYYFNYGFNFKNLKYDDVTTHIGSRLSQITAFDLEATMNDSTRRELLEQLISTELTPKLQLNTEADIIGHLSELTHPNAIPLKVKEYLQLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW7</accession>
    <name>A0A654DUW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12541" checksum="1C983056DC3EBF8C" modified="2020-04-22" version="1">MTTLKNSVQLIGRLGNDPQVRTFDSGKKMATFSLATNETYLNAKGEKVEDTQWHNIVIWGKKADIAEKYLKKGSEVAVQGKLINRSYESNGEKKYITEISLNELLMMDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV01</accession>
    <name>A0A654DV01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="316"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="44191" checksum="1053DDDBDF6ED2F2" modified="2020-04-22" version="1">MDLRENVKEGIKSVMANKLRTFLTAAIIAIGITSLVGILTAIEGIQSSINDSFSNLGANTFDMESVRKNRGSRDGKEAKVFPPLTYEDLMRFKEKFTAGVVSVNAYVSFAAEIKRGSKKTNPNSRVQGGDDNYLLVDGYDIKEGRGFSQIEVQNGAMVVIIGSEIKSALFEKDEDPINKEIKFMGSKFKVVGLLGAQGGTGGNGSVDRMCLVPTLTARRLAAGRQLDYEATVAVYDPTQMDAATGLATGLMRAIRRDPVKEENSFQVTVNQSLAERLGEITGYLKIGGFTIGFITLLGASIGLMNIMLVSVTERTREIGVRKALGATPLKIRQQFLIEAIVICQMGGIGGIVLGIIIGNLTSSLISSGGFVIPWLWIAVGVIIGMTVGLISGYLPAYKASKLDPIESLRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV07</accession>
    <name>A0A654DV07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="58" mass="6866" checksum="31F5B5F7DCFA14E7" modified="2020-04-22" version="1">MQLTSQRNLLALQSELNQLQREMLRKRQEGKLEDIETLEQKVDKLHTELISLKTMISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV52</accession>
    <name>A0A654DV52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Starch-binding associating with outer membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="308"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="493" mass="54633" checksum="EEA3A61BE877921C" modified="2020-04-22" version="1">MKSLKYTFIGLVFFFSACEENLEKPLLGSLTAGTFPQSESDAILAVNGVYNSLRVWNIHTGGFPLLDIMSDQMIKGSNPGDGTAIAPYDNFSHTATEGSGDRWYKTLYQAIRRANLVINEVPNAEIVMDEELRVRIVAEARFLRGYFYSQLVQGFGAVPLVLVTDPALDLTKTSAEEIFNQVIYPDLLHAAEFLPEKSEYSADEAGRATKGAAKALLARLYLFNGDFVNAEKYALEVIASAQYELEPNFADAFSYDHEFGVESIFEIGALPFPFDQGGNQYGNTMGIRGTPNRGWGFGRPAYPWILMMQANNDPRMDASIIFLGEVLDGVETGGDASTPDTTRVDGDIVEIEVYNQKIWHPGPGTNESFGHNKRIIRYADVLLMAAEALNENNKPAEALVYLNEVRERARGGNAGILPDITVTDQAALRLAIENERNYELAFEGLRFWDLVRTNRAETVLGPLGFVKDKNELFPIPQSEVDISEGRISQNKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV85</accession>
    <name>A0A654DV85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024854502" evidence="1">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="42695" checksum="246373B597240FBF" modified="2020-04-22" version="1">MRRKLLFCWVYLLALQIALAQPRLEFDGQVSAVGSYSPENQFPLFSGGRYIPELGYGVELDSGKAFDLEASVNIAGSVFFQPFDTGSWNGSINAYRLWARYTGKQFEVRVGLQKIDFGVATMLRPLQWFNQIDPRDPLRLTNGVYGVLGRYYFLNNANIWLWGLYGNEKARGLDASGTYAQHPEFGGRVQYPVSRGEIALSYHHRTADARLLMDAPQFAQIPEDRWGVDGKWDVNVGLWFEVSHIRKQKDLGDLTNQTFLNLGADYTFGIGNGLNMVVEHLIAGYDSRLLGFGHRGHITAAMMAYPLGFFDQLSALFFYNWAAGDPTFFLNYEHQFKALVGYIMPFYSPRIQKGIQENDLVNSISGPGLRLMLVYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVM0</accession>
    <name>A0A654DVM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1130" mass="125863" checksum="19CB7BF1FA17EACD" modified="2020-04-22" version="1">MADESTNKNTEKQFGLTTLSLNNRTTVYVLTMLVVIIGLMTYVTLPKESFPEVKQPIVYIGTPHPGNSPVDMENLVTRPIEKEVNAIAEVDNIKSTSVQDYSTIIVEFTSDTDIEDALIKVKDAVDRAKPDLPELQTDPNVFEMNFSEFPILNINLSGNYSMEELNEYAEYLEEEIEKISEISKVEIRGINEKELKVNVDPYQMEAREVNFSDIENAIRSENITLSGGSVKEGDIRRSIRVVGEFSYPEEVLDVVVKSEKGNIVYLRDIGEVDFDYKETQDYARLRGNPVVMVDVVKRSGENLLIATDKINVILEKAKQEVFPKDLIVTKTNDQSEQTRELVDSLENNIISGVILVVLVLLFFLGSRNALFVGIAIPLSMFMAFMILGMFGITINMMVLFSLIMALGMLVDNGIVVVENVYRLREEGLSSFEATKQGVGEVAWPIIASTATTLAAFLPLAFWPGIMGEFMKFLPITLMVTLGSSLFVALVINPVLIAAFMKLETGETNRKRIMIFVAVAIVLGALLLLAKATVLGNLLIIAGLITILNVYVLVPSSRRFQRTFLPWLEGLYKSTLDFALSGWKPALFFWGTVLMFFGSFGLMNVFPPDVEYFPKTDPKYINVFIEYPVGTDIEHTNEFTQKIEHIVFDVVKPYESIVESIIANVGQGTSDPNDPSAFGQQDTPNKARITVNFKEFKYRNDIDTKVILAEIREAIGGYPGVAVTVDQNADGPPAGKPISIEVSGEDFATLIEVTERMKKTINESGIQGIEKLKTDLETGKPELVVNIDREKARRFGLSTNSIAMEVRTALFGKEVSKYKEGEDDYEVQLRLMEKYRYDVDALMNKSVVFRDQTSGKMVSVPISSVATSELSSTYGSIKRKDMDRVITISSNVITGYNATEINGEIQELLSNFQMPAGYEFKFSGEQEKQAKEMAFLSKALGIAVCLIFLIIVAQFNKVTTPFIIMMSVVLSTIGVFLGLVVFQMNFVVIMSMVGIISLAGIVVNNAIVLIDFIELSRERKRQELGVDKLPFNEIVEAIAVAGKTRLRPVLLTAITTVLGLVPLAVGFNVDFIKFLNSYDADFYLGGDNVAFWGPMSWTIIFGLSFATFLTLVIVPVMYLFFARVNRYLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW14</accession>
    <name>A0A654DW14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="13716" checksum="F6DD12A9381BFDCD" modified="2020-04-22" version="1">MKNLLYLLVFAVLGCTDDQPSQESDQANLDRLWSEIHAMAESVTCTSAEEWDFSAVGSKACGGPVKFLAYSETIDTVKFLSLVSEHRDAQEAFNIKWGIFSDCSTPQEPSGVACEEGEPVLQYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW57</accession>
    <name>A0A654DW57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="18985" checksum="4E7D2265EDDBAD75" modified="2020-04-22" version="1">MKAATVSEIKRELKTKTTEELSELCLRLSKFKKENKELLTYLLYEAADEESYIQSVKTEMDDQFEEINITSYYFIKKSVRKILRTVKKYIRYSPHKTTEVELLIYFCSSLKEMSPSISRNVTLQNLYDRQLTMIRKKVSTLDADLQYDYGVLLDNMEGISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWA5</accession>
    <name>A0A654DWA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NhaP-type Na+/H+ or K+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="9"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="6">
        <location>
            <begin position="411"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="618" mass="67310" checksum="232780CFAABCFE4E" modified="2020-04-22" version="1">MLELASIFVLGIFAQWLAWKIKQPAILPLILIGLAIGPIATLFTADGSKLIDGDAIFSGDLLFSFVSIAVGVILFEGGLTLNLKEIRSLAGTVRNLLIIGALITFIGGGVSAHFIMGLSWQMSFLFGALIIVSGPTVVIPILRNVRPNTNVNTVLKWEGILIDPLGALIAVLMYEFILSSKHGVDYPMEVFQDFFITISAGIVSGGLGAFFLYSLIKNNALPGYLQNVFTLALVIFTFAISEMIHAEAGLMAATVMGIALANVKLEELKKILSFKEDISVILISVLFILLSSRIDIIQIEKLGWESLILFLIIILIVRPIGVLLSTIGSHLNWREIVFISWIGPKGIVAAAVASLFSLDLIKGDTHIDPKEAELLLPLVFLIIVGTVVLQGSSAKYVASLLGVKRAEPKGILIVGANELARKIAQVIKDHGTYVLLVDTSAPSIKEAKKAGLKTLQSNILSDQIFDEIDLSKIGKLVAMTSNSGLNDLACTWFEKELGETNVFRLASKEEADNTNLPLPKNVLFNARVDFVTLVQLIRVKNPFSEISFESQSEYEGFRSKFATGMIPLFLSGEGDEFQIITGYTSKTDKLTSLVYVKKPNFDSETVPDDDQDVEYIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWH8</accession>
    <name>A0A654DWH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glc operon protein GlcG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="14128" checksum="9EC97CFACA54BEA5" modified="2020-04-22" version="1">MITLSEASLLVKEAMKIAAEWNVQLSIAVCDDHGELVAFSRMDGVGLQTGPLAIAKAYTAARMRKSTLLLGEWAIENGKDISHWVDPKITGLGGGLPIVRNNKVIGGMGVSGLSPQQDEEVVSLSTKVMSEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI2</accession>
    <name>A0A654DWI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl-carrier-protein) reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">MARINOS108_11020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="267" mass="28604" checksum="6123B616040A7EA1" modified="2020-04-22" version="1">MEWLSDELIISHSLNNQEIYMSKLKNRVAIITGGAAGIGRAAVEKYVQEGAIVVIWDVNEAAGKELAVTLSKDGHQVSFRKVNTADPEETEAAAQEAIAQFGRIDILINNAGITRDATIRKMTFEQWSQVLNINLSGVFNCVKAVSPFMIEKAYGRIINTSSVVGLYGNFGQTNYAATKSGVIGMTKTLAKELGKYSITVNAVAPGFIATDMVKAMPEKVIEMMTSKTPLGRLGTPEDIANAYAFLASEDASFISGAVISVDGAVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT5</accession>
    <name>A0A654DWT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="57" mass="6397" checksum="8BA190E70F342A1B" modified="2020-04-22" version="1">MDWIRSRDESVFLCKAKVEQSPTKPMNLSGDLSDLSLIEAKKAVSTRNSPSLYLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW4</accession>
    <name>A0A654DWW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="109"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="50024" checksum="39583359B1CF80FA" modified="2020-04-22" version="1">MNQKEILERIHQSEDNRVKIAITDIDGVLRGKIIRKEKLLSTLEQGAGFCDVVFGWDMMDAAYDNAEVTGWHTGYPDATFHLDPETFRNIPWDEHIPFFLGDFSVTNHPACPRSLLRKVIQKAEKDGYSTGFSQEFEWFNFQETSDTLAAKNGQSPTPLTSGMFGYSILRASQQSPYFNDLFTLLDDFKIPLEGLHTETGPGVYEAAIEYSGALEAADRAVLFKSGVKEIAARHHIMASFMAKWNHDLPGCSGHIHQSLWKNGKNIFHDAKGAHQISSTMESYMAGQLLALPYILPMYAPTINSYKRLVEGAWAPTTLTWGLDNRTTALRVINPSEKATRVELRVPGADANPYLAMAAALASGLYGIKNKLKLTTPPTTGNGYQDLSNGRLPADLKEAIQAMKSSDLAIELFGAPFVDHFTKTREWECRQFAAKVTDWELKRYFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX30</accession>
    <name>A0A654DX30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="58" mass="6728" checksum="4E3BA73124F87FB2" modified="2020-04-22" version="1">MNMASIDLMIWLVRRDQDNSTYIQLKEDFDKVPHTGDELSSENGKTDFWPILRKGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX50</accession>
    <name>A0A654DX50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SiaC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16650" checksum="CD52BD0B1A7077BC" modified="2020-04-22" version="1">MNAYSLHYPLLQELENRNLKVDGPLSINFLEKQSLLIIKGWSLKPELRICYSVILEEIQDHLAANEGITINFEYKIFNAFTTRFLFQTIKTLNAAVAQGKHITINWITEKYNTEIYEMGMDLQGLCDFDFRVNLANLTISPSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX73</accession>
    <name>A0A654DX73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031345">
        <property type="entry name" value="DUF5103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17116">
        <property type="entry name" value="DUF5103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024903233" evidence="1">
        <location>
            <begin position="22"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="426" mass="49882" checksum="33AA0692102978AD" modified="2020-04-22" version="1">MKYLPLLAISLLLANCVPVSYTDTASQKTILYDNAEYEDNIGVVQLYPLSADQQASLDYPVIALNSAGLSLVFDLLEQNTSYLNARYVHCNADWTPSRLTDLQFLSTYNEFPINQYNYSSNTRIPYVNYQADLPAPDKSGNYLLVVYRENDRKNVLFTRRFLVFDQRAQIDVEFTPSATVSQRNTNHQLSFGIRYQQIENPNPLREFKVVLLQNHNWHTPITGLQPTLMRPDQNYLEYRHFNGENNFPALNEFRYFDLRSIDYRGMNVVNVRKETDQIQAFLGLDKSRHGLAYSQLINDLNGGFFLENKDPNDGPLQSEYAQVYFELQSEKLEGEVYIAGGFNNWNLTPENMMSYDESTGSYRGWIWLKQGYYDYFYWLKSDKMPFYELEGSHYQTSNDYEILFYYRDPFNNYDELIGYRRVSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE3</accession>
    <name>A0A654DXE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="92" mass="10337" checksum="DC5D273AE7B6F658" modified="2020-04-22" version="1">MEVKQEETGHKGSFYVEQEGLRLAEMTYSWAGNDRIIIDHTEVSDKLRGMGVGLQLVEQAVAFAREKGISIIPLCPFARSVFNKKPDLKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ1</accession>
    <name>A0A654DXZ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6377 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045957">
        <property type="entry name" value="DUF6377"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19904">
        <property type="entry name" value="DUF6377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6377" evidence="2">
        <location>
            <begin position="247"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="524" mass="60846" checksum="252B9ED153CFAB08" modified="2020-04-22" version="1">MLAVFTLVAQRQPTQLQLLDEALSHKEQFVKEKQDVILRLKKRLRANPNASLEVKFEINDALYNQYRSFIYDSAFGYAKRLINLGYQMNDPDRIGYAKTQMGFITLSAGMFKETFDTLNTVRISDLTEPNKLEYYALMARALYDNCDYNKDANYCEIYIRMADKYIDFATNLSDPESYNFLYLKGLHNLREQRSDEAIKYLNKLLDGGLKLTTHQFAITASTLSYLHLKLGDTTQAINLLVDACISDIQSATKETLAMTRLAELLYMYGQVEEAYKYINQSMDDAIFYGAKQRKSEVGAILPVIAASRLNYIDNQRKTLLGYSIGLTILSVLTIIFALSTLFQFRKLRRQDLVIRQTNENLTAANGMLSEANKIKEEYLGYYFNINSEYIEKIEKFKRSVDQKLISKKYEEIRFVMSRIDLKKEREELYYSFDKVFLKLFPDFVATFNSYFSEVDQVKLENDQLLNTELRIFALIRMGISDSDKLAKILGYSVNTIYAYKNRVKSKALIPNDEFEQRIMEIEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY30</accession>
    <name>A0A654DY30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethyl tert-butyl ether degradation protein EthD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02118">
        <property type="entry name" value="TIGR02118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="15750" checksum="95C46F9318372D99" modified="2020-04-22" version="1">MKLKFILSFLILIICYGVYSQEGQIGGTTESNSVIEEKGLIKVSIMYPFAEGKTFDMAYYVSNHMPMVAGFLGQNLVKYTIEKGVASGIPNTPLPFMAIGTFYVKSLNEYQKAIAPNRDAIRSDFSNYTNISPVILVSEVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY45</accession>
    <name>A0A654DY45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylgalactosamine 6-sulfate sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="511" mass="57528" checksum="667B448401BE4B80" modified="2020-04-22" version="1">MIDNSAMNYHTTMKGGALLHCVKVVAFLLVCFILNGCNDATTGSGVLDGAQISGSERPNIILIMTDDQGWFDVGFNGNTEIITPNLDKLASKGVILDRFYSASAVCSPTRASVITGRNPLRMGIPYANIGHMKDEEITLPELLKRKGYTTAHFGKWHLGTFTKSELDSNRGGKPKYEEDYSIPSQHGYDTFFCTESKVPTYDPMVYPAKFLQGESKRYGWRAVENGATVNYGAAYWKSEHQKETDNVRGDDSRIIMDRVIPFVEGATQDSSPFFTTIWFHTPHLPVVSDSLHRSMYDHLSLEQQIYYGAISAMDEQVGRLWDKLESLEVSENTLIFFCSDNGPENKTPGSAGIFRGRKRSLYEGGVRVPAFVVWEAEIEKGKRTAYPMVTSDYLPTILEILDMDYPHNRPLDGISVWKAIKGQQEVREEPIGFICSPGLSWMTHQYKLIGNEKGENYELYDLLNDKSETNDLMYVRPELAYQMKSDLNAWLKSVENSGKGLDYEVIESSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY57</accession>
    <name>A0A654DY57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="93" mass="9934" checksum="E75C643DC78A4044" modified="2020-04-22" version="1">MAFLIVSCASQKNQTSSNDQRPSGQQAGRQQGPPSFSQLIAEMDANEDGKLAKSEVKGPLANDFSKIDTNSDGFLSESELKNAHAPQRGGPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY77</accession>
    <name>A0A654DY77_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">thrC</name>
        <name evidence="12" type="ORF">MARINOS108_12012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="96"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD14541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="427" mass="47819" checksum="64D17F75BF30BA31" modified="2020-04-22" version="1">MKFYSTNGQSSPVSFKEAVIKSLPSDKGLYYPEEIPELDFLFLETLSYYSLPQIGFEVLRQFCKDDIPETKLQEILEGALNFEIPVVEVEKNIHALELFHGPTYAFKDVGARFLARCLGYFNETENKEVTILVATSGDTGGAVASGFYEVPGVNVVILYPSGKVSDLQEKQLTTLGKNIKAIEVKGNFDDCQAMVKKAFHDTDINAKLNLSSANSINIARWLPQSLYYFEAYKQLQKDKLVVSVPSGNYGNITAGMLAKKMGLPIHRFIAASNANDVVPRYLIDEQYSPRPTVPTLSNAMDVSDPSNHPRMLELHEKSFKDIIKHISGFTLSDEQTLKVMKECDQENNYILDPHGAIGYAALKAGLQKKETGLFLETAHYSKFLSTVEQALGKEIQLPDFVSELMKKEKEAILINNDYEAFKAFLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB2</accession>
    <name>A0A654DZB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="587" mass="66428" checksum="794B58CBF109F54C" modified="2020-04-22" version="1">MKKSVIILGGGVAGMSAAHELIEKGFQVTVYERQEHLPGGKARSIPLPEFTQGNNKDLSGEHGFRFFPGFYRHLIDTMKRTPSGDGTQKSTADNLIEAPIMMLARAGKKPIQMPSGFPNSLADLRLIVEALHADTGLEEGESKVILGKIWQLMTSSKRRRSEEYEQIGWWDYCEADKYSPAYRELFVDGLTRTLVAAKAKKANTFTNGNILMQMIFGFGKPHEISDRILDGPTNEKWLYPWLDYLKKQGVDYHFKTTVVSVKTRGKEIAGVEILENGDLQTKTADYYLCALPVERAAKVLATPELIHLDGRLANLKKLSSQVAWMNGIQYFLKEDVKINAGHIILADSPWALTVISQAQFWADYRWEEYGDSEVNGVLSIDVSDWDAPGVVFGKPAKDCTVKEVILEVWTQMKQNFNVEEELLQDDNVAYVYIDEAIIFDKSFFKEGPSSNPKLNKPAKYGSSLVTENDEPLLVNEVGSWSLRPESYTAIPNLFLASDYVRSVTNLATMEAANETARRAVNGIIAQSGERVPLCSLWEFKEPTWLLYYKWLDEKRYKQGLKWGKPRIKWYALPASWLLRLLGKHKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB5</accession>
    <name>A0A654DZB5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murE</name>
        <name evidence="12" type="ORF">MARINOS108_110115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="110"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="327"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="485" mass="53961" checksum="C77205CB2AC1C59F" modified="2020-04-22" version="1">MKTLKDILYGVSLTELHGDREREISSLAFDSRRVKKGGLFIAIKGLNVDGHDYIETAIDLGAVAILCESLPEKRKKSITYVQVDNSAAAMGIVAANFHDNPSRKLNLVGVTGTNGKTTTATLLFQLFQQLGYKVGLLSTVENKIDHKVLDAQFTTPDSLQLNELLAQMVSQGCTHCFMEVSSHALVQHRTSGLQFAGGIFTNISHDHLDYHETFEAYIKAKKMLFDKLPKEAFALVNADDKRGMVMLQNTKAEKNTYSLKSMADFRAKILHNTLQGLELDVDGISAWFKLIGDFNAYNLLAVYAAGVLLEEEKEEVLTALSQIDGARGRFEQVYNGNNILAIVDYAHTPDALDNVLRTIDKLRTRQEKVITVIGCGGNRDKTKRPEMARIAAEFSNKVILTSDNPRDEDPAVILEEMMKGVPKVAQKNTMIIQDRKEAIRTACNLAEKMDIILVAGKGHETYQEIKGVRNHFDDKEILNEMLNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC2</accession>
    <name>A0A654DZC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_12071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024955381" description="Oligopeptidase A" evidence="10">
        <location>
            <begin position="20"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="TOP_N" evidence="12">
        <location>
            <begin position="66"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="11">
        <location>
            <begin position="260"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD14692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="716" mass="80666" checksum="6D4FC1A85D895CE8" modified="2020-04-22" version="1">MTYKTMNITKALFALVALAAISCQGTKETQAPVSDNVLLQPWTGPYGGLPAFDRMSLTDLKPALEQGMEANLAEIEAIANNPEAPTFENTIVAMERSGNDLGRVYSYYGIWSSNVSSPEFREIQAEMAPKLSEFNSKITQNEKLFARIKAVYEASKKDPLPADQQRVVDLTYTSFAMNGAELDEASKARYAAINKELSSLHTSFSNNILADEEGYVTYLSADQLSGLPESFVKAAAKAATDRGKDGMYAVTNTRSSMDPFLTYSDERELREKVWNIYYSRGDNGDEHDNNKLITEILKLRNERVGLLGFDNYAQWRLQDRMAKTPENAMAMMEAVWPAAIARVAEEVADMQAVADANGDQVTIEPWDYRYYAEKVRKKKYDLDSDEVKQYLQLDKLREAMFFVAGELFNFQFTPIDSGVVPVFHADVKVWEVADKTSGKLIGLWYLDPFARQGKRSGAWATTYRSYDSFDGEKTVLASNNSNFIKPAPGEPVLVSWDDAETFFHEFGHALHFLSSNVKYPTLNSGVRDYTEFQSQLLERWLATDEVINNYLVHYKTGAPIPQELVAKIKKASTFNQGFGTTEYLASALMDMYYHTTDPTNLDPDTFERETLAKLKMPKELVMRHRSPHFGHVFSGEGYATAYYGYMWADVLTADAGEAFQEAPGGFYDKDLAGKLVKYLFAPRNSMDPAEAYRLFRGRDADIKALMRDRGFPVTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM5</accession>
    <name>A0A654DZM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8303" checksum="34F8122E85F70DE2" modified="2020-04-22" version="1">MRTNSRNTRNALIQCDHPIQGLQLIRKMKRAGQPIPKTLILNGPQCQHTLDRMLFRLQTLLGEGSPELVVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN0</accession>
    <name>A0A654DZN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="18160" checksum="734A254BE1103599" modified="2020-04-22" version="1">MMVSAAVLLLVVGYFAAFQKTIRIHQENEYLSALTQKGERQLIAEIAQLSTQKRQIDSLKAVVTRASSKAEIFAVLVSRSEQSNLQIVEINETSKEGAERYECTFSGLYVNMVKFIRFVESDFKSVTLESLDFHKEFERKTGVTHLRVKMILRKNEYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS8</accession>
    <name>A0A654DZS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cspA</name>
        <name evidence="3" type="ORF">MARINOS108_120149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7144" checksum="9F6F18A0B005BBB1" modified="2020-04-22" version="1">MSTGKVKFFNDSKGYGFIKEDGSEKEYFVHVSGLIDEIRQDDEVTFELREGKRGLNAVDVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX5</accession>
    <name>A0A654DZX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="32689" checksum="4D4B484087C0ED36" modified="2020-04-22" version="1">MKKLSILLLGAFTLSCSSSDQTPDAYGNLEATEVFVSAEVGGKIIQSSIREGSLLEENQIILTVDTTQLHLKKGQTEAMISALREKLQNIPIQLEVYQKKEQLLRREVQRVKNLLEAGAATQKQLDDLSGELEVITRQSEALESQLSTANRSILSEIKPLNWQLLQLEDQITRSAIKSPISGTVLQKFKEPGEMVMPGQPVAKLANLEHMEARIFITGDQLLSIKLGGQAKVSIDGTEGNIVYDGTIIWISDRAEFTPKSIQTKAERVNLVYAVKLEMKNDGSLKIGMPVDVTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY8</accession>
    <name>A0A654DZY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="243"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="337" mass="38462" checksum="ECC240E014EFDE26" modified="2020-04-22" version="1">MKKHLTIFGSLLIFSIAMIPAGFQRSLDASTPIATLLFDLGEVKPEHFIEAPTTEAILRGEEIVKLGRTIAPNGSQSSYVSKYYTCTSCHNVVREDPNLTVVDQDARLEYAMTNNIPYLQGSTFWGMVNRETWYNDDYVLKYGDLVRKAEKSLKESVHLCATVCAQGRPLEDWEMQSVLAYFWSLQMQIGDLNLSDSEKKQLAGPTLTNEEKIALVKSQYLQKSPATFANPPDNKKKGYPYEGDPKLGKGIYELGCQHCHRPEGESDVVFDNSNLTYKWLKKHIPDNSELSIYEIIRKGTYAEYGHKEYMPHYTQEKMSDRQLEHLRAFIEHPEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E035</accession>
    <name>A0A654E035_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="PTHR13136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="219" mass="24025" checksum="70E7E2DC0DA2F346" modified="2020-04-22" version="1">MELFLNDSLGQITLEVEEADNARAVIIIAHGAGAGMHHPFMTSISGLFVARGFHVARFNFPYMESGKKFPGAPKPNIETWGLVIDYLCVTYPDLPIIISGKSYGGRMASHLLADQSPAPVKGIFYLGFPLHAPGKNSKARATHLNAVQVPQLFLQGINDQLANIDLMREVLSSLPAARMLEVEFADHSFKVPKASGRTSKEVMHQLVEVTTEWIDTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E075</accession>
    <name>A0A654E075_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Subtilase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="109"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="467" mass="51792" checksum="06C72FC05DFB5620" modified="2020-04-22" version="1">MTRLIGLYVLSILLFAGSTASGQHKYWLDHTSLATLSVILPEPDRCSEWINACTYTLTADQTSAVIAAGGVLTPMLSFAPAALAHKDPILSFALEQIQANYFLKMGLTGKGVKIGIIDGGFLRADRDPTLSHLFQKGLVKSYKDYITPEMEAYGGAIGLDDNHGTEVWQLIGGYDKEKNILYGLAQEAEYYLARTDHGAYEKRIEEDLLILALEDMQRQGIRLVNVSLGYNLGYSDASENYRPSQMDGKSTAIARAVEIAATQKGMLIVVAAGNEARDAWQTLSTPGDAQHALTVGASKFDIWDKMDYSSIGPDYTDFVKPDISVYSTLGTSYSTPVVTGLVACIWQMDSTLTNLEIIDILKQAGNFYPYPNNYLGYGVPTCPNIIKIMSGETIKRPQKVKTSKESYKLTRDFDTKYLVAFHKKDERNVMARVVYRPMGNKVKIKRITMARQTSLLIGTEVIEIFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E097</accession>
    <name>A0A654E097_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nuclease of predicted toxin-antitoxin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12805" checksum="C00071319A0EBBFD" modified="2020-04-22" version="1">MTLLFDQNISPRILRALPPEFSNCQQVRFVGLENSSDFEIFQYARDNHFAIVTFDSDFVDLNAMHGAPPKVIYLNTGNLTTKNISELIISNILRITHYLGSESDDILELIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B7</accession>
    <name>A0A654E0B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="236" mass="27238" checksum="7E428BBBFD88CCE4" modified="2020-04-22" version="1">MIINLISSPRNISTALMYSFAHRSDTKVMDEPFYGYYLNLIGADHPGKEEIIASQPKTVSEVRNWIQHTASQHEVVFVKNMAHHLINMNIDFLEDYRNVFLIRDPRQLITSFSKVIPNPQMTDIGVARQYELFEKLRKTQSCPVIDSNEVLKNPDKVLRQLCESLGLTFEPSMLRWKADALPEDGVWAKYWYKNVHASTGFQKKNPDWVQFPPECEALYSAALPLYEKMAQDALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L5</accession>
    <name>A0A654E0L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="4930" checksum="AFF18B027CD9F979" modified="2020-04-22" version="1">MAELGFLGVVVYTLVHTPLRCGHESRAGDFDLEVNFFLPFLTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M1</accession>
    <name>A0A654E0M1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27393" checksum="5E1F3A8B9F993776" modified="2020-04-22" version="1">MKYFFIRIIQTMFLILVIGLPIYAQNAELSTADSLFANQKYTEALKKYENIFNQDKASPAMLTKMAFIQEGLGNYADALFYLNLYYLKTSDKAALTKMRELAEEHHLSGFEYSDFKFMANFVRNYEVEILIVLLAFSLFLLIYGYSKRKKDELPRVSLFLQALTLVLIGLLSNQLFLADTGIVSQDHSLLMTGPSAGAEPISYIEKGNKVTVLQSDALWTKIRWQEEVAYIRTKNLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E112</accession>
    <name>A0A654E112_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase BoGH3A</fullName>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024813270" evidence="4">
        <location>
            <begin position="22"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="5">
        <location>
            <begin position="639"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="721" mass="79173" checksum="9A3D576398A97FFA" modified="2020-04-22" version="1">MRNFLLASLMGLMLSCTSAQTDENSDKSNIDELISQMTLEEKVHMLHGKGKFTSAGVARLGIPDLKSADGPLGVREEIQNDSWAPAGWDNDFATFFPAGGGLSSTWNLDLVRRYSIAMGEEARAREKHVLLAPAVNLIRSPLGGRNFEYFTEDPFLNKKLVVPFVQGLQANDVASCVKHYAINNQETLRGSIDVQADERTIREMYLPVFEAAVKEGNAYSVMSAYNRFRGAYLSENDYMLNTILRDEWGFKGFVMSDWGAVHSTKESALYGLDIEMGTEIDNYDDWFFSEALIAAVRNGEVSESVIDQKVKNILYVMEKIHAIGSEPQAKGTLNTPEHLQVAYDVAAESVVLLKNDNNALPLKSSEIRSIAVIGDNAKRKHANQGFGAGVKTRTEVTPYDALVAHYPDMKVNYALGYKEQYLKNNLNRSWGLPVDYVPNEQLVAEAVAAAKASDVAVVFAGSNRLVETEAEDRKGLRLPFGQEALIKAVKAANPNTIVVIIAGSPHDLSEIDATVDGLLWSWFNGSRAGDAIVDVLFGEVNPSGKLPVTFPKKLEDSPAHATNSFPGGPDVVIYEEGILVGYRWFDTQNIEPFYPFGYGLSYTSYEYSDLSTDKSSYNAGDIIKVSLKVKNAGAVDGKEIIQLYTSKPGSDIQRATRELKGFGKVALKAGEEKLVTLEIPVKELAYYDVEAKGWSVEPGTYDLSSGASSRDLRGKVSFSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E184</accession>
    <name>A0A654E184_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">uvrC</name>
        <name evidence="9" type="ORF">MARINOS108_140106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
            <begin position="294"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="600" mass="68608" checksum="4C6EBFA6686D1347" modified="2020-04-22" version="1">MESHKFSTQEYGKLPHQPGVYKFYDRTNTIIYVGKAKDLLKRVSSYFNKSNQASRKTVKLVREIESIEVIIVNSEFDALLLENSLIKENQPKYNILLKDDKTFPSICVTNERFPRIYSTRSIDPSKGTYYGPYTSVKAMNGVLDLLRKLYKIRTCNFNLSERNVSQGKFKVCLEYHIGNCLGPCEGLQDESDYMEDIQSAHHILKGNISTVKAGYKELMQNAAEELKFESAQDFKQKLDHLDNFQSKSLIVNPKISDLDIFGVIGDGSKYYLNYMKIEHGSIRMSETVESKRKLDEPEEELLQLILFSLRNKYNSTSTEIISNRPINGWDEIEITQPKIGDKKKLLDLSLKNALFFKNDRLVRSEGKKTSGEKILEQLQSDLGLKSLPRHIECFDNSNIQGTNPVSSMVCFKNGKPSKKDYRKYNIKTVVGPDDFASMREVVGRRYKYLTEENLPLPDLVIIDGGKGQLSAACEPLKELGLYGKLPIVGIAKRLEEIYYPEDSIPLHISKKSPALKLLQHLRDEAHRFAITFHRSKRSKASIQSELDHIKGLGSITKEKLLRHFKSIKRIEMAQEEELAEIVGKSKANILTTYFQQKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A9</accession>
    <name>A0A654E1A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024942764" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="16810" checksum="6D6CC94B753816CB" modified="2020-04-22" version="1">MKKLFTLAFTIFLAQGIYAQGITAKSYIEQTQVGIKLGTAIGYIFPCNVEIGGFHQEPAKFIDNQELPYRFYEKKFTGMYLNLPLKHYDFIGFDLNIRTGVTNGQNFAITPTLQGYVNPIPAVKLGLGLGTRMFQPTLQASISIKISKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F8</accession>
    <name>A0A654E1F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="14354" checksum="F636A90B19D1B8B2" modified="2020-04-22" version="1">MKKILLICLVLAAACSQTKKEDTKGLKDQVMEVHDAVMPKMGELRMTEKQLLAMADSVAGDTTAAARYRELAVAVSSANKSMMTWMHGFDPDFAGSEEEVKAYLEGQLKEIEEVKRLMLSSLEEGQKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S1</accession>
    <name>A0A654E1S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039533">
        <property type="entry name" value="Satl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF60">
        <property type="entry name" value="PTHR10545:SF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="16849" checksum="14BEB364C3CEAACF" modified="2020-04-22" version="1">MIIRKGTKEDLPRALELIRELAIYEKAPDEVTNTLEMMENDGFGEHPVFGFIVAEEAGTIHGMSMYYWRYSTWKGKRIYLEDLIVTEAKRGSGIGKLLFEETIAIGKAAGATGMMWQVLDWNEPAINFYKKYQANIEDGWLNCNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S9</accession>
    <name>A0A654E1S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17311" checksum="EADF8794DDCE188E" modified="2020-04-22" version="1">MSLWPFLRQTLVSSHSKNEVLRRIALKTRLIDSEVVVNRPVFNGAVSPEGFRISLVIRSAQNALPLTIGRVENTSRGSLIFLRLCLFPGARLYLWFSTTLCVLIAAVFLTLSSLTLAVITALLIALANYLVLTLSFHQKAHETIHQIQGILAEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T8</accession>
    <name>A0A654E1T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4689" checksum="089EC16F92658DD2" modified="2020-04-22" version="1">MVTSLRKRWEDSSKKTQKSTSQDHMYHISAVNVLSPDIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V2</accession>
    <name>A0A654E1V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component regulator three y domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="911"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="976" mass="111867" checksum="C15919B0CC08B8EF" modified="2020-04-22" version="1">MLQKYSLFKNQTSIHYSHLLVIGLFLGNIAISQPDHYRFSKIPLTNTYNTDDYQGGIQNWDISRDSRGFIYVANNFGLLEYDGNSWRRYLIENNTRARSVFVDADNRIYIGGQNQIGYFEADAKGNLVFESLLGLLDEHDRNLEDIWKIVKYENNIFFCSYLGLVVYDGKTVRKLHHEVDYDLVFQVANGLYASSLSSGLAKWNGKSFSIIPGSHVLQDHEITAIVPYQNNSLLIFQKNGTVYHYRDGIFRRWNLPITDFLSNSLINKAILLENSNIAIGTQNNGIVILSQNGAVINHLTKGKGLTNRTVLALHEDQFNNLWVGLNNGICMVELASPFSVINEQSGLPGTGYCATLHDNKLYLGTSNGLFYQGANPNPITELADYQLVKNSGGQVYNVQSINTDLLLAHHAGAFLVEDDLATQFYDHTGTWKFENSIGDNRILAGTYDGFVIFKKVDGQYQVENELEEFSESSRVFEFAGDSMLFMTHGYKGIFKIDFNKEKDRIRNISFYGKNKGLPSNILINVFGLGGNKLVFPAETGIYNYDAQQDTFVSDPEMGQYFPKEAHITAMAHDLSGNVFFLNDMELGYLERTQYGSYIKHTAAFTKIKPLLSDDLENIHVIDHQNVFFGAKEGFVHFNPSMKYLRDQPFRTFIRSIEATTDEDRMIYGGTGQLASDEPVSLSAYFSSLKFRFASPYYDGQDQILFQYQLENFEKDWSEWNTATEKEYTNLSEGLYTFRVRAKNVFGDISDEASFQLKVYPPWYRSKLAYGFYGLGLLVVFGASMLVLSMRHSYEKKKLTLKQKRELLRKENEIVEVSKKSEEQISKLRNDKLRSEIDHKNRELATTTMHLINKNEFMLQIRNAIKETSKSGSKDNFKKIIRDIDRNLSEDEGWEQFTKHFDQVHGDFLSNIKKDNPTLTPQEIKLCAYLRMNMSSKEIANLLNISVRGVEISRYRLRKKLDISRDTNLVDYMLEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W1</accession>
    <name>A0A654E1W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CIC family chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_140051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="462"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="527"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="586" mass="64478" checksum="2CAD407FD3C7F181" modified="2020-04-22" version="1">MMTFLVWRLKHISDNNFILIVASVIGLTAGLAAVTLKSTVHYVQQLLQQNIDVTRINYLYIVYPVIGILLTVLVRKFVVRDTPGHGITRILRAISKSSSRIRKRYMMSNMLKSAITVGFGGSVGLEAPIVVTGSAIGSNFGQFVHLDYKKRTLLIGCGAAGAISAIFNSPIAGVIFAIEVILTEVKISKFIPILIASVSGQLVSIVLLGEDILFSFKLVDTFSARDTPWYILLGIASGMASLYFIRITYLVEGAVENIRNQYGRAIFGGLALALIIFVFPPIYGEGYESIKSLLQGNEVKFLSGSFFYGLADQELIVIGILLLVILAKPFATALTLGSGGSGGVFAPSLFMGGVTGFLFSRVVQFILPSSNISASNFTLVGMCGVMSGVLHAPLTAIFLIAEITSGYMLFVPLMLVSAISFTTISYFEKHSIYTKNLIEKGDLIQYDSDLIVLSLIDLKKIVEKDLLTIHPDAKLQELVGLVKKSKRNIFPVVNDRNELEGIVTLDHIREIMFDPEKQANVVVKTIMQKPPAYLNPQEKMQSVMNKFELTQAWNLPVIDNGKYLGFISKSRIFNAYRKKLIRQTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E209</accession>
    <name>A0A654E209_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="14612" checksum="0027F21AF265F42D" modified="2020-04-22" version="1">MKKYLIISTGISLTFLLIYYFLNDSLFQSYLHQQFPALILFFYLQSLAVWWMLRLGEKSNWESPIYVLGGITFRFLTGLFFLAILFIMKMENIRPLMIQFIVLYLVYLIFELFAALPNLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K1</accession>
    <name>A0A654E2K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="696" mass="79649" checksum="91F5559094BF4EBB" modified="2020-04-22" version="1">MSDFQTSKSVFLQKIVAVIEENLANEHFGVTELAEITNMSRSNLLRKVKQETGGSVSVLIRNVRLHQAKLLLADDSLTVSEISYKVGFSSTSYFTKCFRELYGYTPGEAGSRARLASEEVAADVPDTGGGRGRVLVLVVLALVVVLSIVLFSFPEEEEVTPKSQGKSLAVLPFKNDSADSTNIYFMNGLMEAILDNFQKIEDIRVTSRTTVEKYRTLNKTIPELSKELNVRYFIEGSGQKIGNEILLTIQLIEAPGDKHLWSRRYKRELKDVFELQSDVAKSVAKEINAIITPEEQERIEKIPTQNLVAYDHYLKGLALLNDRSGAGLAEGVEEFKKAIQEDGQFSNAYAYIAISYYYLDIFLAEPKYTQELKEYADKAMLLDGESGESLIARSLYYMQIRDFKKAVESFEEVLEYYPNTAWVHNFLSNIYGVILPDTEKYLTHALQGIQAAVADADSVTASYTYLHLSNALAQTGFFNEAETYVQKSLAFNPDNLYSQYLYVYIRQAQHLDLNRAKQSLMTILQKDTTRIDVIQEIAKVCYTMEDYEQAWVYYEKMLNMKAALKLDIYQNEDSRIGFVLEQLGRKEEAKQYYESFLAYAEKDQSLYKDLLYSSYYAVTGQRDKAVKYLKAFSEKDNYQYWIVLFLDKDPVIRKMAGHPDYERTLKKINDKFWAKHKQIRKMLEAEGITVPVRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N8</accession>
    <name>A0A654E2N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043772">
        <property type="entry name" value="MBG_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18887">
        <property type="entry name" value="MBG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1944"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2024"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2270"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2517"/>
            <end position="2592"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_3" evidence="2">
        <location>
            <begin position="2598"/>
            <end position="2668"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="2681"/>
            <end position="2741"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2749" mass="292475" checksum="C3B827554B8084DC" modified="2020-04-22" version="1">MKVHFYFILIVTLLLGREVAATELLVVETYYWIGGTGNWNDGAHWSATSGGEAVNSLPDETINVIFDDNSGTEDFTVTIDDPYNVRDITTSATALDIVFDNTHYSQDFLNIYGNISLNSHVSFEDVYILTSASDSVTVGFNGANMKEDIFFAGEGAYIIISDMTTGRLQHESGRLYLDDGLTLTLHSLFEKGGEGDKLDLADANINIQSTYFFDATSGFEFVAGTSVITTASSLLNLKFDGSGIGAEYHTFVIYSDVPPQGLGEAVFQNLIIEAGSNLTFLFSAGDALTITGNLALNGTVENPVKLRSWYPGSQVSLIMADGAEVSADWAQLTDIKITGEQAYEATNSIDGGNNSGWNIIAPEFDDYYWVGGSGAWEDYENHWATSSGGTTFHTSAPGLYDNVYFDEQSTAGETVVYTDSAELSMGSLMISDLTDHLQLYTTHEFSSSSQHGALYINGSFQSDPLFETNLTDLLFLGAGDQTIHANGDLQDSYEVFIEGIGTYGLLSDLVLKDFSWGRTDDQGLMTLDGFSLETERLQLNSESGYLDISNSAVKASYLKVYDGSKLIDNDQSSVEIYNTGLGGTLDGYLNYDDPAINHLIFNGDVRVVNVDDMFFDTLEFKPGSSVLFDNYASRDITVNEFMADGSLQPISIFGEAGINMVKASGSVSAESVIVKNINATGGADFTATNSLDLGGNAGWIFDGAFVPTDFYWVGGSGDWDDYEHHWAASSGGEDFLMRLPSRYDNVIFDTNSFSEDNSVVTLSSIVKISDLSMVSLSNTMTLKGEGQKGHLHPVRSLDFDPKALIDLKMYFESDSNQTLTADGAQFGEHEWYIYKEAGTVEIVGDLNAPDVNIDHQRGGIVFNDGAEWTDIVLKEYYTYNNTTVDLGKANIIAENFLLSWYSSGTLTEGNALIEVTNRYSDRRNQGVYTLKFNGEVNVESDVTARTLSITSGSEITFLAGSTIDILQNISMYSVTTNPSVIKSSIPGTQYTFSMASYGSVSANGLILSDSEATGGATFTANASEDAGNNTGWTINSIEPLDFYWVAPTNGAQWGNPASWATTSGGSELHTRAPGRYDNVYFDAESFDSEGLLGVIVHPNGHEVANLDMSGMDSPVRFMSYSSSDVLKLKIFESAVLSDKAQFEIQEIYLYDVHTFDVNGATFNKPLTVYAESGDDNVLSIPEGLNLESLEVYGGGIDFGADDFTIGDLHLDNMTSTVDLSGASFEIGESFYVVSDEAVLGTDCSISMPSGGTFGGSAWGSVGQVTLSGEVEVGTYFHINELILDGGADLTVLYKSHLSFDTLIAEGGSQEDPITLSRGDEHPVPSSIYSDAETIELKWGELYGIEAKGDADFIGVATLDLGNNPGWTFTKLDPELVFSELESVTYGDESFELNAAIHEGLQVLYDTEDIDKIGIDGSSVSIEGAGQADIRAYFDGNDYYEAAEIIQPLTINKALLTASPAPKSKVYGAELPEFTPLYSGFVHEEDASVIDTPPTANTDASVGSAVGEYDISLSGAEDNNYTFEYEPGTLTVNKATLTVTAEDKVMTYGGAEPAYTFTYSGFVLDETADVINEEPSGVFVSEMPGDAGLYILSIEEDGNDDNYDFVYVDGELTVEKAPLTASADEKTKVYGATNPQFTITYSGFMNADGPTDIVEPTATTSATELSGVGTYDITLTDGSADNYVLTLEDGLLTVSQKELTVIADDQSKTYGEENPELTITYSGFENGDDTDDLEELPTITTTATLESDAGTYPIELSNGTGINYAVTLVNGELTINQASQEISIEEIPEKKIIDEPFQVTATATSGLEIAFSIDGPATLSGNTVTLSGAPGTVVIYADQEGDNNYLAAETQSILFDVLDTTRMKQEITIASISDKVYGAAPFSFSASTSSGLELTFTTEGPIAIEDELITISGVGTASIVARQAGDEEYNAASLKMTFEIDKAPLTATAESKSRIYGEVNPALTISYAGFVNGETESVITEPSAEVIADELSEVGSYPITLSGGLANNYTITLANGSMSVEKATLTVTPDDQQKVYGEENPGFTFEYSGFVNEEDATVIATAPAFSSDATASSDVGSYEITGSGGEATNYSFSYEIGALTVVKADQVISIEAIDDKDVTAEPFAILASATSGLELSYEVTGPATVEGNIITLTGVTGEVEVAVSQLGNINYHAAATETVSFTVTDASKTNQTISFTEISDQTYGATPITLEATSDSGLNLTFDVEGPAILDGSTLTITGVGEVTVTASQAGNETFNPATLAQSFTVAPATLTVTVQGEIITYGDDLPEFTYELGGFVNGEEEGVLTSIPTISSNASVESDAGTYEIIASGGEAVNYTFAYVSATLTIEKADQAIALEGIADKLVTDAPFEIIGIASSDLPLTYELTGPASLSGTTITLSGSTGTVVITASQAGNQNYHAAITTSLSFSVTDPSKAMQTITFEAIPEKKYGDVFTLGATASSALSVVYAVTSGPASISGSELTVTGVGEVTVLASQDGDESFNPAPSVSMSFVAGKASLIVTADDKTRIYGEENPEFTASIQGFIGSDSEADLEAVPAASTTATETSDAGTYAITVSGGAAQNYTFSYIEGTLTIGKAVAVVSLSNMEQVADGESKMPTVTTDPADLSYEITFDGSSEVPSEDGTYVVEVTIDETNYEGSASGNFVLTKAFTLEAPVRNEVQVYPNPASERVMVEGAAGQLVKIYNLMGVLQMESETNRTIQIGALSSGVYLIRVLDASGQLVSHHRIVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y7</accession>
    <name>A0A654E2Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="14559" checksum="9D01D5ABB79B096E" modified="2020-04-22" version="1">MKRVLAITLLGFLVACSGGGEKPSGWEGEWTATWETDPASFEGIEGISDYTMPGMVIFGPEMVNIKAYGFEGCVFSKDTLDHSLRWRVSNDSLILINDEDTPGMVYQIKEKTTDLIRLQLMEDIFLTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E320</accession>
    <name>A0A654E320_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="286" mass="33549" checksum="8B184552A0917448" modified="2020-04-22" version="1">MENLLDLVDKRASTMVVDRRLLSHYEMKMLFIGLFVSLSSMAFCQQLELADYINIKVQEYERKGEKKISIQPELSAGTPAKKFERRFLYLILNIPEIYTSNSKEKYIEMKSYYPDTMRIANTLLKEYDSDPKLKSYFNQTLEPIIDPESSKEITFSSGELLEVASKFFYCDKVKPDTSIQAHVCVGLNGIKEANWEQDYTLLQAFCFEAIFYGIMDNKDSKIWDAFTYAKQQSSEFHRPTLSSLDQYLEDVKLDLFERMRTNETLERELLAYYEQTRETLAFSIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E322</accession>
    <name>A0A654E322_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="578" mass="63566" checksum="11B30E7398FD72E6" modified="2020-04-22" version="1">MSKSKVTLSHVFKTIVWPRRKIIGVGLILIVISRAASLVLPGASKYLMDDVIAKSDMEMLKVLLLAILGAIVVQSITSFLLTRILSVEAQHLISQLRVRVQRKIMYLPVRFFDNTKSGELVSRIMTDVEGVRNLVGTGLVQLVGGLLTAIVSLFLLINISPMMTLYVLVPVSIFGVISLKAFGYIRPIFRERGKLNAEVTGRLNETLGGVRVIKGFNAEKQEIKTFEEGVEKLYLNVKKSLTSTSLVTSSATFLLGLASTGIMGIGGYLIVQGEMTIGDFLAFTLYLGFMIAPIVQMSNIGSQLTEAFAGLDRTEEIMNLAEEDDGSVRTIRIPQIKGDVEFRDVSFSYEDDNHVIKHISFKAPAGSVTALVGTSGSGKSTIASLAASFLTPDEGIITIDNEDLSKISLDSYRSQLGVVLQDDFLFEGTIRENILFPRPDATEEALMTTVKAAHVDEFTDRFEKGLDTRIGERGVKLSGGQKQRIAIARAILADPRILILDEATSNLDTESESFIQESLARLMSGRTSFVIAHRLSTIRQADQILVVENGQIAEQGTHDELIQKEGRYFQLYTYQARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E343</accession>
    <name>A0A654E343_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="27997" checksum="2F2A396EC6286F9C" modified="2020-04-22" version="1">MRKITVCVALIGLVVSCTNREPDKANNVVSQAVKAHGQGRLANSRVSFTFRDKSYSVSRSEDSYEYTRSFKEDSSWVEDVLINSTDFARTVNGELISVPDTMQVKYTSSVNSVLYFVQLPYLLNDPAVIKSYEGTQKVLGETYDVLKVTFRPSGGGEDFKDEYRYWFHEKTHLLDFLAYNYETDGGGVRFRKAYNRSERGGILFQDYVNYEVPVGTPLQKIPALFEAGKLKELSRIVNTDIQVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E360</accession>
    <name>A0A654E360_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Oxygen regulatory protein NreC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="23589" checksum="E684DBCCD81EDAD9" modified="2020-04-22" version="1">MRKILIADDHSLFSSGMSALFVRAGYEVVGTVEKGNDVLYEVITHHPDILILDLNLPKKNGLEVLKEVRAYSRDLIILVVTMYNDRTLINSVRKEGANGYFLKNSGQTELLEAAAKLKPGDFMVSVTVENSNSADPSDLVEDEFDRLIKLTVREKEILKLLVQGLSSKEIGEYLEISPSTVDTHRKNMLKKLSFNKVSELVSYAFRNNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E383</accession>
    <name>A0A654E383_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025030252" description="NlpC/P60 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="18139" checksum="6B9F103E56EF7ED9" modified="2020-04-22" version="1">MNGTFLKILFIASFSLLMVSNISAQNRKKTKKIDRVIAEGRRYIGTPYRYGGMSKSGIDCSGLIYNCYKTIDVTLPRTAKDQSKIGSSKTWDSIRPGDIVYFKFKQKGEKWYHAGMITYAEKDDIRFVHASTRSGVIESSLMDSYYMNNVKKFRRVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E385</accession>
    <name>A0A654E385_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="8819" checksum="E937148F33D1142D" modified="2020-04-22" version="1">MWKEQDNKLTRTIEFKDFVSAFGFMSKVAIVAEKMNHHPSWSNVYNKVSFELTTHDAGNTVTEKDRTLAKAIDDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z2</accession>
    <name>A0A654E3Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide biosynthesis protein RfbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbH</name>
        <name evidence="2" type="ORF">MARINOS108_20566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="49207" checksum="08B6133AEBB4D132" modified="2020-04-22" version="1">MKFTNLIDDHLISSLRKIAAEKVKQVITPGIDYIPVTGKVLDEDDLLYGVESVLDGWLTAGRFGRKFEYEFAKYFGSKSSILVNSGSSADLVAFYTLTSPKLGDRAIKPGDEVITVAAGFPTTVNPIIQFGAVPVFLDIDIPTYNAKVELLEQAISPKTKAIMMAHTLGNPFDLAVVTEIAKKYNLWLIEDDCDSLGATFNGQKTGTFGDLATVSFYPAHHITMGEGGAVLINNPRLKMIAASFRDWGRDCYCDPGKDNTCKKRFEWQLGDLPYGYDHKYTYSHIGFNLKVTDMQAAIGLSQLQKADQFVAKRRENFQMLYKTMKQFEEYFILPEATPNSDPSWFGFMLTIRDGVEIDRHDLVQHLENNKIGTRLLFAGNLMRQPAYLGIEKRTVGTFENTDKVMNDSFWLGVWPGLNKNHYNYISQIIEDFIKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E480</accession>
    <name>A0A654E480_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050262">
        <property type="term" value="F:ribosylnicotinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034356">
        <property type="term" value="P:NAD biosynthesis via nicotinamide riboside salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026681">
        <property type="entry name" value="NRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF158">
        <property type="entry name" value="PTHR10285:SF158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="165" mass="18922" checksum="2165C203CC7F980A" modified="2020-04-22" version="1">MIIGIGGVSRAGKSTLAEKLKSHLEKAGKSVDIFCQDEYVKPKISIPKVQGVPDWERPSTIKWDSLTNDVQKSEADVKIVEGLFSFYPASLRVKYDAKLFLEIDKEVFLGRKSQDKRWDEEPEWYAEHVWRSYMKYGQKKGDKSEYLDISGEAPYDPKKILEAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D8</accession>
    <name>A0A654E4D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="20490" checksum="776DF6673B0D82C8" modified="2020-04-22" version="1">MATPSARVVPQTPKIKIPTALKDPAKKETPSLLRPKTPVVQEEEVKKPLLEERSTPFDESQVIDAWKAFRKRRLEAGASDTEKLVLDRRLEKTGDTQVTLFMESQLEISILDKFEQDLIQHLRKTLDNTFVQIEKEVTEQESTRNLYTSKEKFEYMAQQNPVLRELKDRLGLDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M0</accession>
    <name>A0A654E4M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="6 11">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sucB</name>
        <name evidence="15" type="ORF">MARINOS108_20830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="6 11"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="107"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="14">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD19728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="517" mass="55002" checksum="7EF410D9D8B0677D" modified="2020-04-22" version="1">MSLEMKVPAVGESITEVTVAQWTKKDGDIVEMDEVICELESDKATFEVTAEAAGQLSIKAQEGDTLDIGAVLCTIDESKAPAGEDAPKTSEPASAGAAKESKATGETVEMKVPAVGESINEVTISSWTKKSGDTVELDEVIAEIESDKATFELTAEANGKLEIIAEEGTTLEIGALICKIEVTDGGGASAPASSSSSGSAASGSSESKETYATGHASPAAAKILQEKGISADAVTGSGKDGRITKEDAMNAEKSAPKQEVIKDKAPAKPESKPAFEAPEIKSGVSRGQNRQKMTSLRKTVSRRLVSVKNETAMLTTFNEVNMGPIMELRKKYKESFKEKYEVGLGFMSFFTKACTMALQDWPAVNAMIDGEEIVYSDYCDVSIAVSAPKGLVVPVIRNAESLSFDQIEKEVVRLATKARDGKLSIDEMQGGTFTITNGGIFGSMLSTPIINAPQSAILGMHNIVERPVVENGAVVVRPIMYVALSYDHRIIDGRESVSFLVRVKQLLEDPTRLLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U3</accession>
    <name>A0A654E4U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="14"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="457" mass="50767" checksum="383D9219C363615C" modified="2020-04-22" version="1">MKVFEKNDVRILTYAIVVALGGFLFGFDTAVISGAEQEVQRIWGLTAIQHGFTVSIALIGTVIGALFGGIPSERLGRKYSLFWIAVLYWISAVGSALATDWNLFLFFRFMGGIGVGVSSVTAPLYISEIAPARSRGKLVALFQFNIVFGILIAYLSNYGLADMGEMAWRWMLGVEAIPALIFLFAVLFVPKSPRWLIVKQGKVDEARDILLSIRDHNLVEAEINSILNSSIGKEERQSLWNTKYKTQIFLVVCFAFFNQLSGINAIIYYAPRIFEMAEMGKSGSLISTIGIGVVNFCFTLLALAFIDRFGRRFLMLVGSFGLIITLGLISWSFYIRDFGSISIYFFIYIAFFAFSQGAVIWVFISEIFPNKVRAAGQALGSFTHWILAAAVALIFPYITKHIGPSNTFLIFTSMMILQLLFVWKAMPETKGKSLEEIEAGDETVAVSSAQHSLNLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z5</accession>
    <name>A0A654E4Z5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gcvT</name>
        <name evidence="10" type="ORF">MARINOS108_20684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="281"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="360" mass="39905" checksum="7503DFB087C77259" modified="2020-04-22" version="1">MTTQKIPLHELHVSLGGKMVPFAGFEMPVRYSSDKEEHMKVRESVGVFDVSHMGEFMITGPQALDLIQKVTSNDASKIVDGQAQYSCLPNDKGGIVDDLIVYRFGPEEYMLVVNASNIEKDWNWIKSHNDFDAQMENISVDTALFAVQGPKAAEVLQRLTEVDLSAIKFYHFTTGVLAEKEMIISGTGYTGAGGFELYVDKQDALEVWEAIFEAGKEFDIAPIGLGARDTLRMEMGFCLYGNDITDETSPLEAGLGWITKFTKDFVNAEALKKQKEEGVTKRLVGFEMVDKGIPRHDYEIVDENGVAIGIVTSGTMSPLLNKGIGLGYVNTGYHQPDSKIFIAIRNKQLEARVTKPPFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E513</accession>
    <name>A0A654E513_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">mutL</name>
        <name evidence="7" type="ORF">MARINOS108_60089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="428"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD20910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="610" mass="69414" checksum="EB464CEE39189DC4" modified="2020-04-22" version="1">MEDIVYLLPDSIANQIAAGEVVQRPASVVKELLENSIDAGGTQIKLVVKDAGRTLIQVIDDGKGMSVTDARMSFERHATSKIRTAEDLFKIRTMGFRGEALASIAAVAQVEMRTKRREDELGTILQVESSEIKKQEPLATKDGTSISVKNLFYNVPARRNFLKSNPVELRHITDEFHRVALANPEVAMSMTNNDLEMYQLEAGKLSKRIVQLFGKNYQQQLIPCDEETPHVKVTGYVGKPEFAKKTRGEQFFFVNGRYIRNNYLNHAVSTAFQGLLKEDYFPFYVLFVEMDPLHVDINVHPTKTEVKFDDDRMLYGVINSAVRQSLGSFNVTPSLDFSTDVNFEQFTSSAMRSGGGSSIKDNQYAQFKNIDSERDKAKNWESLYDFAKREDIISSEQMEKEMPEETVTFSSSMHEHPDQGELIPSKTYRLHGKYLIRQVKSGMTIIDERAAFERILFERYQTKLTRDASGSQSSLFPQQISLNPSDYSLVMEIKPEIQKLGFEFEEMGQHMIVIQGVPAELSNCNEKEIFEELLEQFKFNKKELGINQKENLCRSLAKRTAAIKCKNLGDQEAEQLIDQLFACKQPNYTPDGNPTYKLISLDKIKSWFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E572</accession>
    <name>A0A654E572_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-mercaptopyruvate sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sseA</name>
        <name evidence="3" type="ORF">MARINOS108_50048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="31342" checksum="C8323DF81AA0D2F7" modified="2020-04-22" version="1">MEVNSLDLPDALVSVNWLAERIHHPEVIVLDASIPPVQGEVDPALVGIRIPRARFFDINGRFSDLSTDLPHMMCSAEVFTREAQALGINQRHTIILYDYLGVYASPRAWWMFRAMGHERVAVLNGGLPAWKAAGLPTEHIVSAEFEKGDFRANPQSGFFRNADQVLDAIGNEKECLIDARSAARFHGTAPEPRRGLRGGHIPNSLNLPFTELIRANQLIPKEELKGIFEKLEIKDQHVTLSCGSGLTACILALGAHVSGYQNLSVYDGSWSEWGQPSDLPVVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E593</accession>
    <name>A0A654E593_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Starch synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="3">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="269" mass="31321" checksum="ED90D38BC379CA6F" modified="2020-04-22" version="1">MSNLRILYVASEINPFLKTTEVADFVRRLPQAMQERGMEIRILVPRFGLINERKNRLHEVVRLSGINISVGDEEKPLIIKVASIPNAKLQVYFIDNEDYFHRKSVFFDKEDNFYEDNDERAIFFCKGVLETVKKLGWSPDIIHCNDWMTSLIPLYVKTTYKNDPIFKESKTVFTIYDNNFSHKFGADLLEKVKMIDIDDSMLGPLKTADYEGFVKMGVEYADAVNIANQETTESFKKLMNDLADKRIDTIEKDENFEDSYFNLYNELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5E7</accession>
    <name>A0A654E5E7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">der</name>
        <name evidence="11" type="ORF">MARINOS108_11147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="180"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="439" mass="49154" checksum="C60E23CF51C4AB61" modified="2020-04-22" version="1">MRFMANIVAIVGRPNVGKSTLFNRLIERRQAIMDNESGVTRDRHYGYSEWNGKSFTVIDTGGYVEGSDDIFEGAIRTQVKEALQEANVILFMVDCITGLHGLDQDFANVVREVGKPVIIVANKADNTEKSYAANEFYALGLTDSIYAVSSVSGSGTGDLLDETVSHFAEEVEDEEKDEVPRIAIVGRPNVGKSSFLNALLGKDRTIVTNIAGTTRDAIDSRYNLFGKDFILTDTAGIRKKAKVKEDIEFYSVLRAIQALQDSDVCIVMLDAENGLEAQDMNIIGLAHKYRKGSIIMVNKWDLYEKDTKSADEYKKHIAEKLGPLGYIPVVFTSVINKQRIFKAIELALKVAENKNKRISTSVLNAKMLKEIENYPPPSVRGKHIHIKYITQLPTKTPAFAFFCNHPKDITESYERFLINKLRSHFDFEGVPIKAIIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5H5</accession>
    <name>A0A654E5H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_11177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="10">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="33383" checksum="4C5D54D1CD0C3DE0" modified="2020-04-22" version="1">MEQKTRTKRKLGSYPFVSVTFSITLALFVIGLFGLMALHANKLTNIIQENIELQVFLNKQISAGEVSKINRTIGSKAYVIKENNEPRIRLVTKDEAAAQFIEDTGEDFKEFLGDNPLRDVLIINVKTTYQSADSLKMIKKDIEKMSGVYEVSYVESLVESINENLAKIGVILIGFFTILLIVVVILINNTIKLALFSQRFLIRSMQLVGATSGFIRKPFLKRSIWYGFLAGLFSSLMLLALLMYANQRIEDIRALQDFKNLGILFGGLIVLGITVGLLSTYRAVKKYLQMSLDELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I9</accession>
    <name>A0A654E5I9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YknY</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yknY</name>
        <name evidence="5" type="ORF">MARINOS108_140169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="228" mass="25113" checksum="B0A095A22E4C5B51" modified="2020-04-22" version="1">MLTLENIHKSYHLGKQSLHVLKGVNVNVEEGELVSIMGSSGSGKSTLLNILGILDSYDEGSYTLGGHLIKNLSEGKAAQLRNELIGFVFQSFNLLNFKSAIENVALPLYYQKIGRKKRNKIAEGYLERVGLKDWSHHLPNEMSGGQRQRVAIARALITNPKIILADEPTGALDSTTSHEVMEIFKEVNANGKTILIVTHENDVAAATQRVIMIKDGTILSENHDMSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5W7</accession>
    <name>A0A654E5W7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="74"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="28272" checksum="C796DBA94B2E2B9E" modified="2020-04-22" version="1">MFNRLKKYPIIVHVVRSVRLLLGQTPEKLSQRFHISRQDQLIQDYMSSSSPKKLQIGAQGNSINGWLNADIEPKANHVVYMDATKTFPFGDNTLDYVFAEHMIEHIPYGDADFMIKECFRVLKPQGKIRIATPNLMGAIQVLQNPDTPEHKEYIDHYYNLFIDQGVPRDPAFVVNKLFYGFKHRFIHTEFTLTHLLETNGFNHVRKYEVGESNDPELTGVEQHMNEMGLVPNKVETIVMQAQKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E629</accession>
    <name>A0A654E629_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">rpsO</name>
        <name evidence="8" type="ORF">MARINOS108_90065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="10655" checksum="FB12134141807B39" modified="2020-04-22" version="1">MYLTKEKKEEFFTKHGKGTEDTGSSEGQIALFTFRINHLTEHLKQNKQDHSTRLGLMKLVGKRRRLLDYLYKKDIERYRSIIAELKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E677</accession>
    <name>A0A654E677_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trk K+ transport system NAD-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044849">
        <property type="entry name" value="CASTOR/POLLUX/SYM8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010420">
        <property type="entry name" value="CASTOR/POLLUX/SYM8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31563">
        <property type="entry name" value="PTHR31563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06241">
        <property type="entry name" value="Castor_Poll_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Castor_Poll_mid" evidence="6">
        <location>
            <begin position="272"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="391"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="633" mass="72192" checksum="C16EA5CC0F3D43FD" modified="2020-04-22" version="1">MSKFPLKTRLNYKFDNYLSKGTAAMIYGLGILSLIIIIVFGVLLLMFGLHPDHDKDFTIFESLWVNLTHVLDPGVLGNHEDNWPFRVFMLFTTFLGLVIISTLIGLVSNGILTKMDELRKGRSFVIEKDHVLILGWSSKIFTIISEIVIANENQRRGVIVILADMDKVLMEDEIRDKVGSTANTVVICRTGNPIDVHDLYIANPFDTKSIIILDKDNENSDSQIIKTIVAIVTNPERREAPYHITAEMEDKKNFEVAKMVGKDEVELILSDEIISRIMVQTSRQSGLSVVYIELMDFGGDEIYFMEEESLIGKTFREILFAYEDSAIMGIQYADGSVEINPTMDTIFREGDSVIGITEDDDTLVPNSPEFIELLEDKIVYTEPEVKDEEKILILGWNNRARHIIRELDYYVPPGSHVKVMSKFDDAAKAINKLSNLVENIHLSFEVTDTTDRETLQNMDLGQYDYIMLLCYQNYFPIQEADAQTLITLLHLRNFTEKNGQKYKIVSEMLDIRNRQLADITSADDFIVSDKLISLLMSQVSENKFLMRVFEDLFDADGSEIYIKPAKEYVKVGEPMNFYTILESAARKNEVAIGYRVIKEAKEANKGYGVYVNPRKSDMFTLTDKDMVIVLSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E696</accession>
    <name>A0A654E696_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="14564" checksum="6522BE60A0C7D83A" modified="2020-04-22" version="1">MDNFCVIDQDGGKVKVTCTANNGVRANVAVGVYKHHPTGEWELVEQLNLVTGDDGEDAKEVVTSPSTLIGKFITWNVNFCAFVPGAIQSTITIKFSQDGVDLPTTEPTKKVVSDPPKCQNGQMGNYSDKLKFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6A4</accession>
    <name>A0A654E6A4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="236" mass="26213" checksum="FA789BD1FB28DE8D" modified="2020-04-22" version="1">MIIFLLKKSTPLSKQLAKMNSQKRPLFGLFLILIGLVLLLSNLGVISGLPGYIFSWINIFLLLAIANLFSGNYRSVLLFAALWGFFILRQYTDIQLRDYWPLILVVIGLSMLMRKRLRSQVTSTTDDSFDEINIFGGSTKKYTSTSLKGGKITNIFGGSEIDLRDCQPEKVVVIEVLTLFGGCELIVPKEWNISVDTTAIFGGFDDKREASSHKDPAVVYIKGITIFGGGSLKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6C8</accession>
    <name>A0A654E6C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_90110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25782" checksum="000517CA6808FFD2" modified="2020-04-22" version="1">MKLLVIEDHDQLSANIRTYLHGEGYVCEVAGSYQQAVEKLYAYQYDLVALDLMLPDGNGLDLLRTIKENWPQICVLIISAKNALDDKIKGLDLGADDYLAKPFHLAELNARLRAIFRRKNQQGDDKIQFEDMELNTQTFEVVVGGQVLDLTRKEFELIQYLLLNQNRVLTKQSIAEHLWGDYMDTADSFDFVYQHIKNLRKKVAEAGGTDYIHTVYGVGYKFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6N0</accession>
    <name>A0A654E6N0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="441" mass="49248" checksum="9A5ABECFDEF9FA4E" modified="2020-04-22" version="1">MDHLKKPSFKEACWFWLKLGFISFGGPAGQIAIMHEFLVEKKKWISESRFLHALNYTMILPGPEAQQLATYTGWLLHGTKGGLVAGVFFVLPSMFILCGLSALYATYGNIPWVYAMFSGLKPAVMAIVILALIKIGTKSLHTTFHFLLAGMAFVLMFFFNTPFPYIIIGALLLSFVVRKMLPSLFKQTTSAQEQLTKDEEQYFINRNHFLPDAGFKVGRLVRQVFAAALLWVIPIGLFYLFSSDFSFWKQLSLFFTQAAFVTFGGAYAVLPYVAQVSVEQLNWLTELQMIDGLALGETTPGPLVMVLVFVGFMAGYNHYDGSVLMGALGLVATTFYTFVPCFLFVFAGAPIIEKTRENEKIKQALTLVTAAVVGVILNLTIYLGKAIVFPEEMTLGGIDYPILGWVVVSFVAMYRFKLNMITWIVISSLFGLVNHFITQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6W9</accession>
    <name>A0A654E6W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="6">
        <location>
            <begin position="87"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="841" mass="94674" checksum="3A195869EF83D9A3" modified="2020-04-22" version="1">MKKIQLLFWVGLMLTEQVIAQEVFHVGFNEVSGTNTTTEEVSSQSLSIENLFDRPERITSPDGNALRLDGWSTYISQSNFSLSGIDRALTIEAWYATEAFNRESSSIIELSSASGASGFYLSVGPYGELNFGYHLDNTFYVHNTPNRLSTYQWHHIVATIDLDAGETRVYVDGVVWFLKQGLSASSISVPESTLYIGKRSLDQRANGFSVNVLNGALDDLKVYNVALTEAEITDASQSVPERKVDLYIDPAVRFAGDHLRPQYHPMPNNSWANECYGLMYYEGNYHLFFQKNPNAPQLYFMHWGHLISPDMVHWREVDIALRPTPGFDNFGAWSGTTLKDNAGSPYIFYTGVDGAKAGIGMAIPTGDSLLTWTESESNPLLANAPTSFSHMDFRDPYLWKSDGLYYMIVGSGLQNNGGGILFTYRSSDLVNWTLIPRLYANSDISEYGEFWEMPTFRKLAGDTYLLQLTPTPNNGKPARSIYLLGAWENETFKPYFETPKSLELFDSHMLAPAFGTDDETGDTYIGIIPEDRDGNDQINAGWRQTFSIPRQVRLLEDSTIGQIPHPNLCRLRSDEISVEKLVLENGKRNNLPQFRGNQIEMEFDIKADSNANFVIQVLKHEDEREYTTITFDYELNKIILDRRQSSLSNTLKNTRIGNFVFNPNDTLNVRIFIDHSTLEVFVQNLTVFSARVYPSRAESDLVDVVAIDGEVSVVSAKKWEMASMLDHEVVGQSCVPSNLPTHFNKTPKEPEEPEEPLKSGFKSGWKLYPNPSFDVINLDTPGIENGQYFIYSLSGQQLLSGAIDQERAAIDVHQIPAGMYLLTASDGTLFYSERILIKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6Y9</accession>
    <name>A0A654E6Y9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17040" checksum="DADBF6B70E4306BE" modified="2020-04-22" version="1">MKAIQSNLIILLLLLCFVLGCEKEDIQKENKTNIVGTWLLNATSQSNCDDAELNGLQSYECTDDNCTKYIFSSDSTGMNYIKEFIEDGILMSEVGTYSVGESKLTMCVETEDGPECTSFKLALTVSTMNISGKNDETGCTEALYFDKEAQEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7Q0</accession>
    <name>A0A654E7Q0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">dnaJ</name>
        <name evidence="8" type="ORF">MARINOS108_20728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="375" mass="40779" checksum="8AF2F70117A97E3E" modified="2020-04-22" version="1">MAKRDYYEILGVDKGASKDEIKKAYRKIAIKYHPDKNPDNKEAEEKFKEAAEAYEVLSNDEKRQRYDRFGHQGVGGAGGYSGGGMNMDDIFSQFGDIFGGGGGSPFDSFFGGGGGGRSRRTRKGTNLRIKLKLTLQEIANGVEKKIKVNRLVVDPNTKFATCSTCQGTGQVRKVMNTMLGQMMSTSTCPTCGGVGQTVDSRSPGTDSSGMKREEDVISVKIPAGVSDGMQLSMSGKGNEVAGGIPGDLLILIEEQPDETLKRDGTNVIYELHVSFIDAALGTEVEVPTVNNRVKIKIEPGTQSGKILRLRGKGIKDIEGYGIGDQLIHVNVWTPKHLSKDERATLESLRDSENFTPNPTKGEKGFFENMKEFFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7Y5</accession>
    <name>A0A654E7Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase/recombinase y4qK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14216" checksum="183BE2B209557196" modified="2020-04-22" version="1">MTIRVSQGKGKKDRVSLLSKRLLEDLRKYYRAWKPKDYLFEGPDGGPYSGTSVVKIVQRAAKRAKIGQRVTPHTLRHSFATHLLEAGTDLRYIQALLGHSSTRTTEVYTHIAVNGLSKIQNPLDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9K4</accession>
    <name>A0A654E9K4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yoeB</name>
        <name evidence="5" type="ORF">MARINOS108_60114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="85" mass="10290" checksum="D062A09B10632D18" modified="2020-04-22" version="1">MTLVFTANAWEDYVYWQKVDRKMVKKINDLIKVIKRTPFDGIGKPEPLRYDLAGHWSRRIDLEHRLVYRVSGDELLIYACRYHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB53</accession>
    <name>A0A654EB53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">atpG</name>
        <name evidence="10" type="ORF">MARINOS108_140118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="33070" checksum="CCF63AC14D17437F" modified="2020-04-22" version="1">MANLKEVKGRIQSVTSTQQITKAMKMVAAAKLRRAQDRITQMRPYSQKLSAIIQNVSAGVDSDQVDNPYAEAKEVGKVLLVVVTSDRGLCGGFNSSIFKHTKALVAREYADVEAAGNLMLMPIGKKAYDHFKKRGYNVIEDYHHLFSNLDFAHALEAAEFVMSEFLEGEFDKVEIIYNEFKNVATQIVRNEQFLPVQNVSAEDDAPAETIDYIYEPNQKFIFSEIIPKSLKIQFYKTLLESNASEQGARMTAMGQATDNAGELLKELKLTYNRTRQAAITKEILEIVGGAEALAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC36</accession>
    <name>A0A654EC36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="93" mass="10631" checksum="193C2C39D47EA73C" modified="2020-04-22" version="1">MKAFWNGQLIAESNETVVVENNHYFPPSDIKSAYFKPSTTHTVCPWKGTASYYTLEVDGKTNMDAAWYYPETSELAKHIKGYIAFWKGVEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECG8</accession>
    <name>A0A654ECG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="349" mass="39860" checksum="10931EC5754823A2" modified="2020-04-22" version="1">MHRTVSRLKSLWYKVTHWEFWPFAVLYFPVNFYYPWLAFRCQSLFFFTAANPSIDFGGMLGESKSAIFDLIPEKYLPAYRLIAPGDESAAKTFAQQIGYPLIAKPDIGERGKLVEKINDEQALEKYLAKCPVPLLMQAFVSFPLELGVFFVKHPNNAEGRITSIVEKDFMSVVGDGHHTVKQLLDSNPRALLQIDTNHPRFQLLLEEIPQKGKKVTVEGIGNHCRGTTFLNANNRITGQLNSTFNTIAKGIKDFHFGRFDLRCTSWSDLEEGKNIMILELNGAGAEPGHIYQPGYSLWKGYRAIFWHLSTLAEISRANRKKGIPYWTFAQGWKKMKTIRAYNRKIESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDC2</accession>
    <name>A0A654EDC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen(Starch) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="PTHR10176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="616" mass="71456" checksum="627B96CEFCC770FA" modified="2020-04-22" version="1">MVKQGKTTVKAKRLTKTHTSNTLLLEIAWEVLNQVGGIYTVIRSKVPTVIPKWGNNYCLLGPYMSANVTAEFEPEEPLNNDPIGRAVRRMREKGYGVHYGVWLVSGRPKAVLFDLGSVMHKLGEIKYLLWENHGISTPSDDHLLNDVLAFGELVKLFLTELAEETKDSNKQIIAHFHEWMAASGIPGLRKDRVNVKTIFTTHATLLGRYLAMNDPQFYDHLSFMDWQKEARHFNIEANVMIERAAAHGSHVFSTVSEVTAAECRQLLGRNPDVILPNGINNQRFEALHEFQNLHLENKNKIHSFTMTHFFSNYTFDLDKTLYFFTSGRYEFLNKGYDLTLEALARLNHRLQTEKSDVTVVMFFITKRPYYSINPDILESRALLEEFRHVIDSIKKQVGERLLFDAVSRKDTKLPELNEFVDDYWRLRFRRTLQTWKSTSLPPIITHNLHDDANDEILNFLRTSNLINNEYDRVKVVYHPDFINYTNPLFSMEYGQFVRGCHLGVFPSYYEPWGYTPLECIASGVPTVTSDLAGFGDYVQDNVPDHDRRGIYLVKRNKKSFDEAAGNLANKMYNYVRLSRRDRIDLRNRTESSSSLFDWSNLIRYYDQAYLRALEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF74</accession>
    <name>A0A654EF74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043906">
        <property type="entry name" value="Gfo/Idh/MocA_OxRdtase_bact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19051">
        <property type="entry name" value="GFO_IDH_MocA_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C2" evidence="2">
        <location>
            <begin position="166"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="441" mass="49064" checksum="ED23E05647590945" modified="2020-04-22" version="1">MKRRTFVKNTALAAGALSFPNILRGGINQHNKINIGVIGCNGMGWSDTNSLLKMPEVDLVGICDVDEGVIAKRLVDYQKLRTNKPTQYGDYRELLNDKKLDAVVIGTPDHWHCKQMVDAVRAGKHVYVEKPVANTIEECGIMVDAARDTGKVVQTGQWQRSGPHYRKAREIVQSGVLGKIRVVKTWAYQGWMGAIPVVSDGPVPEGVDYKTWLGPAPARPFNQNRFHFNFRWFWDYAGGLMTDWGVHEIDIALWIMEEKAPISVVASGGKLAYPDDASETPDTLQAIYQYKDFNMLWEHATGIDYGPYGRREGIAFIGNNGTLVVDRSGLEVLVERESIGYSNKGESKMSPVAPVTKPDAENYLDMHTQNFVAAMKANDPGLLNTPIDSGSIAAINAQMGNIAFKTGEKVYWDQEAGKFKNNPEANQYLMANYQNGWKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSJ6</accession>
    <name>A0A654DSJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ORF">MARINOS108_10058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="96"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="21873" checksum="F5E425326BABCA92" modified="2020-04-22" version="1">MFTGIIESLGNLKETKRDGTNLHLKISSDISHELKVDQSVNHNGICLTVTEVQDGAHWVTAIDETLKRTNLGTLSPGDEINLERCLQMNGRFDGHIVQGHVDTTAVVERVEDKDGSWIYRFELGPSEEVMVEKGSVCINGVSLTCFDIFENFFSVGIIPYTFDHTNFRNLRKGSIVNIEFDIIGKYIKKLQTKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DST0</accession>
    <name>A0A654DST0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="24222" checksum="9F2230E814773887" modified="2020-04-22" version="1">MIRYIFSSFCGLFGFLLVSAQDTLYYDSGAIRSVGRLVNGQQQGVWIYYYPDGSLNSRLSYREGALDGEQLFFGFSGTLESREFWVNDLLQDSAFYYYPDGLLERHGMYEAGLYYGLWQFYHANGRLRQEGSYREGLPHGLWLSYYENGQVRDEGFYTNGLESGLWKFFDEGGNPTYEGHYEQGQRVGQWYFYNKSGKRKKWRNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSW2</accession>
    <name>A0A654DSW2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018677">
        <property type="entry name" value="DUF2157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09925">
        <property type="entry name" value="DUF2157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2157" evidence="2">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="426" mass="47980" checksum="47F885ED051EF924" modified="2020-04-22" version="1">MALSKDLDELVQAQVISQQTADEITAYYASKKEASGSSLFVIFGVLGAILVGLGIILIIAHNWDHLSRLQKTILAFVPLVSAQGFCAFSLIRKRNNQRWVESSAAFLFFSLAAAIAMIGQIYNIPGDLPAFLMTWMLLSLPMIYIMKSSMLSMLYLIGITGYGAETGYSSQDPSEWYYWAMLLGALPHYYLLLKKHPKGYFTHIHHWLIALSLTTMLGTVAHSHEELMFIAYCSLFGLFYAIGHFSLFQSVGTLANGYKLIGALGTLIILLILSFEEFWSHLSQPRWQLPDVLTSPEFLVSLLITLAATWVLSLRIRKVGLPHILPMEWVFLLFIPTYMVGFFSSISVLIVNLIILTLGILTVRQGAREAHLGLLNYGLIIVTMLIVSRFFDDQIPFVWRGILFVLVGIGFFIANYWMLKKRKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT45</accession>
    <name>A0A654DT45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="350" mass="39533" checksum="3E9D12934F267F4A" modified="2020-04-22" version="1">MRVIILFLAIHTLVACSNPKKAGPQTTETDTAAPAISWLEDWLSAWELISTEVLQLPVAAAPTMLFYDQKYVYTTSQVSAPDGVSFNGPSFFGTKLDWWMQEHHDTLTIPDGQRVPVQLMTFAAPSSSPGSAPFFVMAAPDFWKTAGIDSEEVGLEKMLTGVFLHEFSHARQMNGLGERVSFLEQNGNFRYEVSDDLIQEYFSGDSSYVSAFKKEVELFYQAANARNTTDRLKLSRQALDMYDQRQKFMSSLDSTLVELDDIFLTMEGTGQYMIVSWLTHPRCKGGSVDLKMAIKATRRQKTWWSQDEGLALSLLYQQLSKQPDWAPFYTSHPVTLIESIRNELNQIAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTJ1</accession>
    <name>A0A654DTJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA</name>
        <name evidence="9" type="ORF">MARINOS108_10348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="92"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="22494" checksum="C5E53F57B8C68286" modified="2020-04-22" version="1">MSFELPALPYAYNALDAHIDTATMEIHHTKHHQAYVNKLNDAIKGTEAEGKSLEEIIKNISKFGAGVRNNGGGHYNHSLFWTILSPSPAKAPEGALKAAIDKKWGSLADFKTQFEQAAATRFGSGWAWLYVTADGEVAIASTPNQDNPLMDVNPENGTPILGLDVWEHAYYLKYQNKRPDYITAFWNVLDWKAVEANYAKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTX8</accession>
    <name>A0A654DTX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="28281" checksum="022005AC70ACA14E" modified="2020-04-22" version="1">MKYIILEDEKLAAERLKKLVLASRPDYQCVLTMDSVESAVISLPALRVDLVFMDIQLADGNSFDIFDQIKLDVPIIFTTAYDEYALKAFKANSVDYLLKPIDPEELEKAIQKFERHANKGNEQVDGLLKSLQPKGKERFVVKVGEHLKTVETVDVQLIYSQDKATYLFTKEGRKFLVDYTLDKVEDLLGADQFFRISRKFIVNLSCIKDIIAFTNSRLEIVIAGFEEEQVIVARERVSEFKAWLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUF5</accession>
    <name>A0A654DUF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Component of potassium effux complex with KefB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kefG</name>
        <name evidence="2" type="ORF">MARINOS108_10712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="23245" checksum="0C85B3669162F41B" modified="2020-04-22" version="1">MSKILVLFAHPKFERSRVNKLLVEKIRKRSSVTFHDLYERYPDFNIDVVFEKELLAKHDIIIWHHPFYWYSCPPLMKQWIDVVLEFKWAYGPEGNALKGKQALNVLTLGGSREVYCAEGRNHFTVNEFLRPFEQTARLCGMDYLPPFAVLGTHRLSDNDLAKYAAQYDALITLLLQGVTPREVGKCDYFNDVEELKNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUH5</accession>
    <name>A0A654DUH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024969937" evidence="1">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="471" mass="52787" checksum="5E8EB0038C2DCB3D" modified="2020-04-22" version="1">MKNSLTYLTLFVIALAYACNGPKSATEEALPPYINVSYTVPKDLSSDASPELLAKFAWEELIALNWKSSYDLSQKRGKPDTTWNFSQSGAYPDLLVWETYAHRSELRPYYGQIQPFDNPPHYSFGNQPAPIPGTNARFDLFNNLDESNEIGSCNLYAYDTSQMVLYQAKVNRYEYDYIQQYYGDSASLAQAAARTQNNINTLSAYCPECPTNCDSPQEAGVICLPCGGAENEGSIEVKTAWRMLTDQDDHSRFYKDSVIYYEKGNDGEIYYKNGVFGLIGIHIIHKTENYPTFIFASWEQVDVTEAKMEFILLNGNAQPTGTPQTVKRLHGVPPVIDTVNNNVHALLKKINMESIWQYYRLIGVQSRPVNSIEEDPNYYMANFVIESDSTLANFHGSSIGKPFDGGNNTLYNKTFYNMGGCMGCHGATQLKGTDFSFLLDFAGKPVKDPDVIDLIPTEPSPKVKAYILGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP7</accession>
    <name>A0A654DUP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12228" checksum="2BA646AC7C899654" modified="2020-04-22" version="1">MGVTKTDLFSTVQNEVAVAAKAFAHPARVAIIQHLLRTNACVNGDLVQELGLAQATVSQHLRELKDIGIIQGTIEGSRISYCINPVRWAEIKSQFNEIFNQFDLPSSQECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU5</accession>
    <name>A0A654DUU5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmI</name>
        <name evidence="6" type="ORF">MARINOS108_10862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7418" checksum="4636489D8CB2A1D9" modified="2020-04-22" version="1">MPKVKTNSSAKKRFKLTGTGKIKRKHAFKSHILTKKETKQKRNLTHATLVHPSDERNVKHMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU8</accession>
    <name>A0A654DUU8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein MARINOS108_10766</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29235" checksum="0355DDE35BA145E2" modified="2020-04-22" version="1">MIAVLSPAKTLDFETEISLEKSKARLFDRSKVLLETLKDKSGQDLQDMMSISDQLAELNVKRFQKFSSRHTPKNSKQSLFAFRGDVYVGLDADDFTEEETAFAQDHLRILSGLYGLLRPLDGIQPYRLEMGTQLPVNGHKNLYEFWGDTISKTLNKDLRKQGDKILVNLASVEYFKSVDRKALKAQVIDVDFKDFKNGEYKIISFFAKKARGLMARYMIKNKISQVEDLKAFDYEGYYFDPQNSTETFLAFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV1</accession>
    <name>A0A654DUV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024893670" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="15103" checksum="D472F32C4656EF02" modified="2020-04-22" version="1">MKSIQRMMGVAALIMIFTYNTQAAPDDSNAVKKAKDAVEGAAPYDWKTMAQSAKVCFRKQENVEQALEWINKSIEINKDPFNLEIKADYYRDKGEKDEALKLYSEALKVGKEQNFWFDGTDIQAKIWKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV05</accession>
    <name>A0A654DV05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="37545" checksum="EBFDE941A303E408" modified="2020-04-22" version="1">MKHVTIVVPECIVNLNSIGGAYEILSRANGYWQKIGNSPKLKIQVAGYAQEQGLKEQFFKVYPDDLNQIKKTDLVIIPSIFDDFTKTVKRNEKLINWITRQYKEGAEIASMCSGAFLLAATGILDGRTCSIHWNSTEEFKKMYPDVKVAQDQIITDEKGVYTNGGGYSFLNLMLYLVEKYFDREVAIFCSKIFQIDIERTSQSQFSIFHIQKTHGDEIVEQAQSYIEEHMTEKISFEKLADSLAVSRRNFDRRFIKATGNTPVEYLQRVKVEAAKKQLENGRKPINEIMYEVGYVDMKAFREVFKKNTGMSPLDYKTKYNSQAAVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV78</accession>
    <name>A0A654DV78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="7480" checksum="D6430B1C921F29CE" modified="2020-04-22" version="1">MLQISYQTSTSRLQLELRYLQMEMLQKRQERRFEEIEQLETKVDRIHSELMRLRQFVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV94</accession>
    <name>A0A654DV94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="337" mass="37928" checksum="7465EFD74494C508" modified="2020-04-22" version="1">MKQNNRSLKVNLYTIIAVYFLILVGGIVRSMGAGMGCPDWPKCFGSYVPPASASELPANYEDIYVSSRVEKNERLAATLLWFGWEDLAQRVTNDPSIGVATYFDTQKAWVEYINRLVGVVIGFLVIMNMIFTLKYIRTIKWVAILGVLSFVLVIFQGWIGSLVVSTNLLPGFISFHMILALLLVALLLTQRYLMSSRDEHRVTGGGWLLVLLVLFTIQIIFGVQVREEIDVIKHGTDIDRSGWLDQLGLLFYVHRSYSLLLTAIVGYVVYLNWKHRTVSAFLKSLVVIICIEIGLGVIMAYFSFPAFAQPLHLLLGTMAFGVIFYLFLYANSNAQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ5</accession>
    <name>A0A654DVQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="312" mass="35550" checksum="881DB2BCAC07D971" modified="2020-04-22" version="1">MKIIQSSHDSKQRVQIIHDDKILLTVAPWYGAKLTAMKLNAGQEFHDVLWPISDADLESNAWFKQSILFPFPNRLKDGQYHFEGRSYQFPINEIEVNNQLHGMLFNAPFKVTDTRESDLEASITLAHEYSGELPYYPFPFVFEVTYRYYLSGFSVKFQVKNTGQERLPFGIGWHPYFQIEGIGVNDYVFSSGDLEEIALDQRTSIPTGERKLIPNPVLALNKHKLDNAYQLKGETTYSLKGPDALRVSFRVSDSLSYLQLFTPDGGETIAIEPMTCNVNAFNNQEGLLTLEPANSFDCEVQIELIKDTNMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU5</accession>
    <name>A0A654DVU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="17633" checksum="7B7FF24243932E5F" modified="2020-04-22" version="1">MARSRLMEMHNIGIVVESLDNAIAFFTEIGLTLEGRMMVEGEWAGRVTGLGNQSAEIAMMVTPDGHSRLELSQFLNPQTIADHRTAPVNSLGYLRVMFRVDNLDELLIRLEKHGAKVLGEVVQFENMYRLCYIRGAEGILVGLAEQLGSDTAADLLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW6</accession>
    <name>A0A654DVW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025003293" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="580"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1179" mass="129033" checksum="FA69BCA856E07375" modified="2020-04-22" version="1">MRSLATLFFFITALSQVAAQDTELIIPLGHTRRVVDMAVSPGQQWVASIDGSTEVKLWDHVSGRELYHLHHQQSVNAISYHPRKQWLASGDDGGQLILWSDHGLKKWTIQAHDEKIKQVRFTSGGDTLVTASAGQIGIWNAASGSQIAQWSSPVESIESISVMRNYLIIGGGQGELAIIHVTTGEVINQQKVSEARIGSISSGQTGAFLGTDAGELIKLDWKTFGITKSAPFSLRNYRVVSDPIQNLVYACGRDANENVKVFDAKTLQALPLSFEIETDKNSEAFKFGLRAMTVAADTLLLIADYQQVIRTYDLKNKLWTSPIFKGTAAAVYDLAVNRAENQLAIASGHGSIKVIDLTGTQSDMILTGSELGTRAIDFHPVNPVIAAYGMDEQIRVVNLISREEIFTLKAKGEYSTTPITFDPTGKYILRKSSSSDFDFYQFKSKTPKNLKVKDGQQYEFSPDGRRLVFQTPSGLSIYDPITLKAIKEIPIKEIQDISISAQGLTATLLRDDQTIHIFDKDYQKTSTLTIPTEGHSDKIYWSPDGQYLIGIRNSTKRGESGPDFSIKIIDVRDGQVTSTLKGHAGFTNSIAFINGHLLSSAVDGKINIWDLNNAQNPLKGSVVPLDDDQYVITTPKGLFDATPRAMDQLHYVKGGKIVALSQMKSAYYEPHLLSKLLGLNAEPIRTSADLSGVSLYPELSLDHPLKNNGKLGINLSNSGGGIGRVIIMINGKEVSSDVRAASVTNEASIEIDYDITNHPFLYNDRVNKVSIKAYNSDGTLSSEEKSLYIFGEEKNTVTPRMFAIIAGSSDYAGEALDLKYAAKDATDLANAIGLSAQEYLGAENTHITLLTTDQEKAFWPTKENIKSAFESYSKQAKANDVLLVYLSGHGVNQGGENSDFYYLTCTAESGDMNNSLTRENSAIASSEFTEYIKSVPALKQILIIDACHSGRLASSLATSRSAMSSTQIRALERMKDRTGLFVLAGSAADAVSYETTLFGQGLLTYSLLFGMKGAALHEDGFVDVMDLFQFAANKVPELAEEIGGIQRPEIRMPEDGKSFDIGKLSESSREKIAIKAPKPVYVHSRFQDESSIYDRLGVSDLMDSKLVELSKAKDAPIVFVDDKSFSGATIISGRYTESGDLIRARVSLIKKGTEPEEVNLEAVNIDQLTEQIVELLKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW51</accession>
    <name>A0A654DW51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18097" checksum="3194EA9FA5A4E89B" modified="2020-04-22" version="1">MWWYNRGIICAINHHMKNAIIVATLLFLGACTRPENAPQFIGIENIEVSKIMGTNAVLKAEAIFYNPNDVKMKLRKVNIDIELEGKKIGVINQEFTTKVPALSEFRVPLNASFDITEIGLLNGIISILGGKKVVVHYKGFVKVSVHGYPATVPIDFEEEVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWF3</accession>
    <name>A0A654DWF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044023">
        <property type="entry name" value="Ig_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19081">
        <property type="entry name" value="Ig_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig_7" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1922" mass="204253" checksum="FFEC4060EDCF78C1" modified="2020-04-22" version="1">MAYDANDPYNGCKSVATYTLKEDNPVYQIKLADIVTKDNDNCTGTTNGYIAIREIYVDGVAVDLATNGTDYTFTWSGNTTAGDGTLETVNAVGDSIGTVGAGTYTVFVTNTSAGGNACSSASVSVTIADDTENPLIELVTLSDDTFCDPTADTGDGQLEVKITGTPGIDVTEYLFRWWAGTDTTIAAMEITNAANFGGTIDVTAADSSAIEGLPSGKYTVVAYDANDPYNGCKSVATYTLKEDNPVYQIKRVDIITTDDTNCDNNNANGTINITRIFKDGIAVDLSVSGGDYAFTWTGLNAGANPFTVNSVNDNVSDVLPGTYTVYVENLVDNLCRSQAVNVTVGQDGIEPTFDTPVVTEDTYCTGGNGSVTLAILAPDTDEANYDFSWYEGTGTAGTFRGDLSGVGNFSATNLNAGFYTIVVTAQATASEGTGCTDMIVVEVEDNPDVIKIAANQIVGTPITDCSPHNGQVVVNNVTLNGALVGTAGYTFTLYESDGVTPSASTFTGASTSANLSPGTYFVSANDAVTGCTTPLRSVIIDYDTEQPTLSIALDRLNSSCDVANADGQLTLSITGADMDANYTIDWYLGTVSNPGSAELLADGVPSAGGFTPSITISGTTPPTSTISGLATARYFARVTDTTNPNANCNNVIAKSVLQDSTFAISMTLTASSQTNCTANGEVVINSITLTTQDGPTSVSGEAVDGGVANLIGTYDLQLLNANQQLITAVTTDADLQGLSEGNYFINATHQVYDCESNSFPFQIVEDIAYPEASVTTIEPNTSCTSTGVGSIEITLLTDGVANAYTVDWRNGSLPTSPAVTPAEGTASSSANTFTLSGLSAGNYTAVISDATSGCSVNFTYEVLENLSYPTINIPDGQVTHNTLCGAGNGAITIDDNDITYQGAAGLVADYDWTITSSIGQAGFPQALNAPAAISLSNLLPDTITFLATHRVTGCSNGSLELIILDKSRLPEIDSLVMIPNANCDGGGIAQGLIEIREIDGIAPSAGNYDYQWYVGTSASAGNEVSVVLGESDSTELVQNLPDDFYTVEITNNNTGCVSTQTIEVQNDPDYPIIISYEVNKNLTCFTVGNGSFVITQIRYQGTDLSMGNSADSLTIVSDYTLLLFASDGVTPMTDGDPATTMKLDSLSAGTYYAAIRKNDSNCDSEKVQFVIKDNPFYPQIQIIQVEADSTCSETGTTPNGMLLAIPDNANDPIHIDSSYTFNWYEVDPGTNARITGSISSNDTLSGQYQGKFEVEVVNVNVGCLSNAYFTLTNEPEELRIVAIDSVSMTACSPSNAFFEVTMINIGNLTDYTYYFYNGDPTIGNPNDSLIYSGPSPILSFNDTGFDVVPDEYYVIAMSNITGCSTDIYQIEITDKTTRPGITLEAFSLQTNCDPANPNGSLTVSANGSQDNTLYIFEWTNSAGTVVEANNATADSLAADTYTVTITEVATGCSVSENYTMIDDYPDPLKLSVTSEGNSNCVNPDGRLAAKVNNIPDGKSASDYQFYWFIGDQTAGTPDPTQADWIGTVYSGLEAGTYTVYVVDGTDAFCTSVPRAVTVEDLRDTPDFRVDVINDVTICYPTLPNGRATIGFTEGELFRYTFLWYEGAISDTTGLTPFVSNKQSVDSLSIGVYTTAAIDKITGCIGYQQFNIMDATETVGLPTLVKVSDRTNCIYPDGRALARVNGNTEGYTFNWYEQGNLTTPVFTGSDVSTLDTTTYLVEAIKISTGCVSARVSVEILNGIEDPEFEVFTTGSICLRTEDGAANQFNGTADIYFEVFHEIDTISWINPDGISVSSDVKLIGAEPGIWSVWFRSDNGCDYTREFEITAALKIYNGISSNGDGKNDFMIIDCIDYFPNNRVSIYNRDGSLVYETKGYNNIDRRFDGTSNVGRNGLKLPVGTYFYFIDKGDGTEVVNGYLELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM7</accession>
    <name>A0A654DWM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="24250" checksum="C37829AC925698B8" modified="2020-04-22" version="1">MPPILFGLFLKFRDDKPMQINTDLLKNKQRIYIGGNHGVDEIFEIVEIVLKHIKKPADFYTIGTEFTSTDAPIVIMKGGDALHNGKAIFHQLGIHILLIHKIEEDIPSSYNSFDSYLAEFETLADNLPKAGCFLYFEDDDVALLMGKKEREDVKEIEYTSLDAEPVPGGFSLKTNGGAVIYKTDNDRFPHHAAGAKALLNRIGVSDDQFYSALKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW7</accession>
    <name>A0A654DWW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024938289" description="Histidine kinase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="470"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="688" mass="77940" checksum="FF84AF3294A46876" modified="2020-04-22" version="1">MNLNAIITFLFFLAALPLGATEDPISIQGDIATCAIQQPSPASISIGQYFGGLLDTSRWPARWTCGDWNETEGWVYIISDITIFLSYFSIPIMLLWYVREKPLGHLRWIVLLFVAFIGLCGITHLLDATLFWEPVYRLSGFTKLLTGLVSMATAVVLGFVIPSALKFKSPKEMQEEINERRKLQEIFEIFVKYSPGATAMLDSDLEFMMVNDNWYRDYKLEGADITGLSFNAVFPNADTDDNWTNALPAALTGQVTESERAKLKYNGETIYLKWRTQPWRLSNGKVGGVFLFTEIITENVRLEKELFQKNKQAQKQAQTMLGMSEVAQIGTWEFDLINNTIEWSDVVYDIHEIERGENIDLTKGINFYHNDFRNIITKALDNAIQHHEPYDLELTLITAKENVIWVRAIGQPVVKNGKVIALRGLFQNIDTKKKAELILANMNSLLEKKVLQRTSELENVNSELEAFTYTVSHDLRAPLRAINSFSEALIEDYGDLIPENGVRYLSRITRNSVKMGQLIDDLLEYSRVTRITGGYETINVQKIVSELIEDTFTNSSSHIKIKPLPSVQGIQSLVRQVFQNIISNAIKYSNNEDQPTIVLEGQTMGNEVVFSISDNGVGFDTKYSEKLYGMFERLHTDDQFEGTGVGLALCKKIMDRHHGRIWAVSEEGKGSTFYLAFPVNVSDKPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX24</accession>
    <name>A0A654DX24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="350" mass="39270" checksum="F5F9667AEAB174F6" modified="2020-04-22" version="1">MQLSYKIGIVLVFTFGTLAGRAGGLDSLRVEKNKGQYFVIHQVEKGETLYSLARRYGADLEQVVKLNDIQNNQISLGQELKLPIDKSKARQASEMKPVEPKASSAMEEVTHTVVQGETLYSISRKYGVAVEDMKKWNSLPSNEISIDQQLTIRISDDQAVPAPVEVKKPTKETPKPKSTVPPGFTEYYVQSGDLLETIAAKFKVKPDSIVFWNHLPNAYLSIGQKLLVRGKPDSVRIAQNDAVEILPYGQRKTVKDQSGFTRVFEEGTARKIEDGMETQKYLALHRTLSVGALIEVRNLMNNQKIFVRVVGKLPETGLNENVMIRLTPICFERLGVIDPKTRVEVSYYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX32</accession>
    <name>A0A654DX32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">MARINOS108_11270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="430" mass="46297" checksum="729683677D8490E8" modified="2020-04-22" version="1">MKIEKSKSLFSRAKNYIPGGVNSPVRAFKAVGGDPIFFKSAKGAHMMDEDGNSYIDMINSWGPMILGHANPLVEEAVIRAIQSSPSFGAPGEREVLIAELICQLVPSIERVRMVNSGTEATMSAIRVARGYTGKDKFIKFEGCYHGHGDSFLIAAGSGAMTMGTPDSPGVTAGTTKDTLLAPYNNLDAVWEIVNNHKGEIAAIIIEPVAGNMGCVLPVAGFLEGLREICDQEGIVLIFDEVMTGFRLARGGAQERLGVIPDMTTLGKIIGGGLPVGAYGGKKEIMDFVSPQGPVYQAGTLSGNPVAMAAGYTMLRYLSDHQETYGKLESNTKRIVSGYRETLEVLGLNYTINQIGSMYSLFFTDQQVVDFETAKSCDTALFGSYFNKMLEQGIYLAPSQFETLFVSAVLSDDDIDQIIRANDESLKSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX46</accession>
    <name>A0A654DX46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">leuB</name>
        <name evidence="16" type="ORF">MARINOS108_10133</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD10622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="352" mass="38496" checksum="046FF5CBB7D579DB" modified="2020-04-22" version="1">MNFKIATLPGDGIGPEIVDQAIKVMKAVGEKYGHSFDFEFAPTGASAIDLVGEPYPDSTHEICMNADAVLFGAIGDPKYDNDPKAKVRPEQGLLKMRKKLGLYANIRPVATFPSLIDKSPLKNDRVEGADFVVVRELTGGIYFGDKGRSEDLTSAFDNCVYTTEEIERILKLAYEYAGKRNKRLTVVDKANVLCTSRLWREIAQKMEKDYPEIETDYMFVDNAAMQLIQWPKKFDVMVTENMFGDILSDEASVITGSLGLLPSASVGLHTSVFEPIHGSYPQAAGKNIANPVATILSAAMLLDALNLLEEGQAVRDAVNASLEANFVTEDISKEAAKSTSEVGDWIAAQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC5</accession>
    <name>A0A654DXC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="15240" checksum="762A49946F0C1E97" modified="2020-04-22" version="1">MRQFHLYQLWFLVPGLGLVWLGYYLPASYIYQQLYWVETEAVITGYRLDTTATPINYYLMDYTDSLGTVYHVEVDVENTITEGRDADHARLYYDPADPANFALVNHARYLVVLFLPLGLLSLYFGWPKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC8</accession>
    <name>A0A654DXC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hbdA</name>
        <name evidence="6" type="ORF">MARINOS108_11316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="185"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="31844" checksum="D078B630C8DA6007" modified="2020-04-22" version="1">MNNISVIGSGTMGNGIAHVFAQHGYQVALIDISEEALKKALATISKNLDRQVAKEKITEADKTATLANITTFREVAQGVKNADLVIEAATENFEIKKQIFQTMDAHSPAKAILATNTSSISITKIAAETKRPAQVIGMHFMNPVPVMKLVEVIRGYATSDETTQAVMEASAKLQKSPVEVNDYPGFVANRILMPMINEAIYTLFEGVAGVEEIDTVMKLGMAHPMGPLQLADFIGLDVCLSIMKVLHEGFGNPKYAPCPLLVNMVTAGYKGVKTGEGFYQYTPGSKDLVVSGMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL4</accession>
    <name>A0A654DXL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="26698" checksum="EB4C18597E52C7AF" modified="2020-04-22" version="1">MNDLPIYISLTFFACVLASFGFIYYAILTAAGPKSNIPLFAITFMAVWIFVTSLMTINGFFQDYEAMPPRLIMMVLILVIFIISLFLIPATRNFLNQMPITTLTYIHIIRVPVEIVLWWLFINGVVAESMTFEGVNFDILSGISAPFAGLFLVGLKSKSNIAAIIWNLLALGLLVNIVARAILATPYFYDPAVYEQPNIAVFYFPYVLLPLFVVPAVLFSHLVSLYQLIFLKEPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM2</accession>
    <name>A0A654DXM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="33"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="20953" checksum="D736211BABBCB671" modified="2020-04-22" version="1">MKKTIFLVALITVIGCSTPQETTPVPAEPTTAELLERGKTLVTVGGCRDCHSPKIFNETGMHFDESRAFSGHPEGSSLPEIDKRALSPGYWVLFSGDLTAAVGPWGMTFARNLTPHETGIKGWSKEVFIKAMRTGQHMGIEKGRPIMPPMPWENQKELSDQDLTAIFTYLQSLKPIDNYVPEPIPASELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV3</accession>
    <name>A0A654DXV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16308" checksum="879D1E549202C165" modified="2020-04-22" version="1">MGWINTLFTNRSEKEHINKLVIIAHYEHIIDQEDILLLKQEIGYISLENKMVEVDKIRKNLPKTARERFNLVFFLVNSLMANGALSDRKEGIVARLLQVLDLSKEKAKELTSFLKLNIRNGLSMEDSFSRLGYLLEPSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY33</accession>
    <name>A0A654DY33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="646" mass="72639" checksum="6A9ED004E6A3C300" modified="2020-04-22" version="1">MTDEIQDVLNFLKTMAYKESRRHFIKKSAVATAGLSLGISTLSVACRDKVLGGENTFKVIRNGRSLSFKLPVNLDISQVEVRLFSKANEYIFEYDDVSPNAPKVQNEQTKDVWMAGFDEQADIRRNSGREQRFPTVDIAMNPDMEAIIEMNVKEQGIYDFNDTGENPVAAEIRIPYEKVEYWGNSLILDPKTNSIAHFYLSTKVEVADSKVSYQFDVLRDDWVGAVSIHQVDTGEFIASAEVTWDGTLPKVSTGSGVSRERMVAALSWATHYVLDCEDTKSDSATKGGEYLLYDLSAKTRLRPAWAWAWGPSAKMFLEAAALDGVDTEVTGLSQEALKQRAIEIGNITLDRLVTDPSSPAYGIVKTSATEASTVDALFLVGWGWMPLYRATGDQRYIDAGRKVAEKLNLLMDEHDDVWIPQAYEFHKKEWKTIMSFESSMGLPGLAALYFETGDDYFKKTTIRLADLLIRAFEKEDGMWGVFFYGDKKKSGPVNYWTKAFGYIADGLIEAHRVAPEQGYLKKVQVIADAIMETQAADGSFSVRFDRDPEFVGVGEKATTLWAGLYIRIYKLTGDKKYYDVGMKTLEWCMDNQYFGEDPAARGGIISRSWPSGINFRHWFDVVVTYSVSFFGNSLAEALSLDEWKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA1</accession>
    <name>A0A654DYA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="272"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="385" mass="42514" checksum="0D8FFE372DF7AB4B" modified="2020-04-22" version="1">MKLAFILAYKNLVGSGLRTWLNVSVLSFAFVLIIFYNGMIDGWNEQARRDGIAWEYGGGHLLNGDYDPYDPFTLQDGHDTLQTNENKGLIPVLMRQASIYPEGRMMSVILKGIDPGQTTLKLPTQLLAERSADLPVIIGKRMAEATNLEVGDEVLIRWRDKDGTYDAGRATVVDVFDTNVPAVDNGQMWISIHQLWQMTGLQNHATLYISETARNSMEVEGWEFKSQGELLQDLSDIIEMKKVSGSIMYLLLLAIALLAIFDTQVLSIFRRQREIGTYIALGMTRLRVVWLFTIEGSMYSLLATAVGCIYGIPLFIYMATAGIGMPTASQNSGVIVAARIFPVYGAGLILGTMALVVVSATIVSFLPARKISTMNPVDALKGKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD9</accession>
    <name>A0A654DYD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="29844" checksum="493BC0E9756CE8A0" modified="2020-04-22" version="1">MKKYLMFMSAIVLGASTIFMSSCKDDEGGDPVIVEPSLIKTISIDYSGGAGEEVESWQFNYDDNDRVASIDVFWNGESDGTTVYDYSVANQLTITRGESSTVYILNAEGLVIKELWDDEGTEWEGYEYNSDGQMIKVVEHYGGVDHLKYDLVISEGNVTNRIRYNDDGTVREDREFTYTIGDNLSGIHQIYQVDSEWKNVGGTFGKQSAKLADGYLRKITEDPSSAFTAKFVYTFDEENRVATQTKNGTSSGGPFSESWAYTYYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF4</accession>
    <name>A0A654DYF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="20571" checksum="4C67579293E1F742" modified="2020-04-22" version="1">MIVYQKAYDLYHTVYRLIKLLAHFRGDGDIEIDRLRIWDYYVLFPNRMRAIKHKKSEKDIKAIIHQYILRPENPYEPLHNDRKTFEKIKPYQLTAIKCLASYGMINKDYLNNNRITSISRDFFSKYDEDFKNLSIQEENAIKLLTSHYYKISLFGPYGLKAKTGLLESKYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH5</accession>
    <name>A0A654DYH5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="170"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="384" mass="41454" checksum="4D453AC09272810E" modified="2020-04-22" version="1">MVSIEEAFERIAKQRPVRVKQDVYLSEAVGLHLADVVVSPMDIPVFDNSAMDGYALCGESDTYRIIGEVAAGSQSELTLAPGQAARIFTGARVPKGTTAVIMQEKTLVEGHALSLTEIPAAGANVRIKGEEIRQGQEVFQAGHYINAATVGMLLSLGITSVSVFARPRVGILITGNELVTAGEPLGEGQIYESNGGSLQAALQQLPVEVTGVTKVTDDLESTSRAIRDLLDEADILLISGGISVGDYDFVKEALAQNEVEELFYKVDQKPGKPLFFGKRKHQFVYALPGNPASSLTCFYLYVTPLIHQFLGGAAKVPERVRLGHDFEVRGARPTFYRAKVEEGVATILDKQSSSMLHSFALGNGLVFLSPGTHNKGVEIPVWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT0</accession>
    <name>A0A654DYT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Component of SufBCD complex, ATP-binding component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">MARINOS108_110032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="27648" checksum="B014B66BAC10E017" modified="2020-04-22" version="1">MLKINNLQASIEGKQILKGINLEVKAGEIHAIMGPNGSGKSTLASVLAGREEYEVDGGTVEYLGKDLLDLAPEERARAGIFLAFQYPVEIPGVSTTNFLKTAVNQVREARGLKAMDAVSFLKEMKEKMKLVDIDQALLSRSLNEGFSGGEKKRNEIFQMAMLEPKLSILDETDSGLDIDALKIVADGVNKLRSADTASIVVTHYQRLLDYIVPDFVHVLYQGRIVKSGDKTLAYELEEKGYDWIKEEVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB6</accession>
    <name>A0A654DZB6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="671"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="968" mass="114182" checksum="FD47612A82759B0D" modified="2020-04-22" version="1">MKMDQEKKRASPTFISELADRILKENDGKLDQVTVVFPNRRAGLFFRQSLSAFITKPIWMPEVASMQDFVGRFSTARSIETLEAIFVLFEVYKTHQKNEETFDQFFFWGEMILRDFEEIDQYLVNPEQLFTSIKSQKELDEEFYFLDEEDKRIIQSFWSSFLPKTTKSQEAFLETWKILLPIYTEFKATLRKRGEAYGGMIYREITEHLSETQLRTGRKVYFAGFNALTHTEEKIIKHFVQEENAQVIWDLDDYYFSNPRQEAGFFLRDYSSDSVLGKTFPKDLPKRFETEKYMDATGVSLEVGQTKVLAETLKELAASPSFDPQRAVVVLPKEHMLFPTLHAIPDEIDKVNITMGYPLKDTPVYSLLESVLLLQNMRKDNLINGTSFYYKPLIELLEHPLLYVLEEEPIKKLVREIRSRNRITLYQEEIVLEHPIFTLIFQKPENAFEYLLSILKELYATWKDKSHDLELEFISRFYLHVSQLHEMMGERSEGLSYDFLIKLFRRLARTLKIPFTGEPLNGLQVMGILETRNLDFDHVFILNMNEDSWPAAPRRGSFIPYNIRKAFNLPVFDHQDAIYAYLFYRLLQRASHVHFFYNTVAEFNVNGELSRLVQQLEVESKFTIHKRILASPIKTEAPKPILIQKNEVILGKMERYLEGFEGDRETRPSAFTPSAINTYLDCRLKFYFKYVERLYEPDVVQEEMDPMVFGNILHDSMELLYKEFIKREKRDVVYPEDLFWIREGVRGAINKAFIKHYGIKNEKKFQLEGRSVIAADILTKFIHKILEYDKQYAPYRILGLEADSRDGYSIDFPVETGGKTRHIKLKGIIDRLDIKEGKVRVIDYKTGRDEKVFTTVQSLVDREDKNRKKAVFQVFFYSYLFKQKYTGDYELIEPGIFNSRDLFSKDFEWKVFDNQQKTGVSNFDQYESEFEQVLSEVLTEMYSAEQPFDQTTDHKKCGFCPYREICGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP9</accession>
    <name>A0A654DZP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative OmpL-like beta-barrel porin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024982062" evidence="1">
        <location>
            <begin position="27"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="37151" checksum="80A6C1B6D3429C4C" modified="2020-04-22" version="1">MNTFTKLSKRFLIAAMLLLAVVTVKAQEEESSFSLSGSVDTYFRTNLNAANYTDFDDDGVKEIQAPGSSFANLPGFSLGMVNLIAAYEGEKVGFVGDLVFGPRGADAVFGSAPALNIVNQLYVYWNVSDALTITAGNFNTFLGYEVISPSANFNYSTSYMFSYGPFSHSGVKADISAGDVSFMVGVFNPTDATDFNPSGEYLGGAQIGYGGAYLNFLFDDEFFQADLTAGWDLSESFYLGVNATSASDNFFGAALYLQNSFSDAFSMGLRGEYFSDKGVGVLTTDESIIDLTLSANYTVGSLTLIPEVRLDSFSEDDVVVTEFNSPTDFKTGSSLSSFVIAAVYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E026</accession>
    <name>A0A654E026_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024933659" evidence="1">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="36315" checksum="E8D090A261C238D0" modified="2020-04-22" version="1">MKKIILIFILGAFITSSNAQDLDKFLEGGAENGEKLLEGYLEPAFVGFGYALNSGWYNTGKPHKVAGFDLTINANLAYVPQDAQFFKINPADYNNMTTAPAENGQTSYPTIMGPNLEADDIPYLVFDEGTEDEIRITAPTGLGMEESLGSNFVPAPSVQIGIGLIKNTELKLRLLPEQTFGDPGEQFTTKMFGLGVLHDVKQWIPGIKNLPFDLSGFFAFNTMKNSMEINADVPDQIGEFNVSGTTLQGIISKKLSVLTVYGGVGFSTSKVNFKMKGTYDGIPEVDPIDIEYKNGGLRANVGARLKLLIFTFHAEYAVQKYNTLTAGFGISIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E073</accession>
    <name>A0A654E073_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="PTHR28026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="DUF962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="18318" checksum="D6E48EC4BFB71BC2" modified="2020-04-22" version="1">MRKIDQLLTEYGESHQNQTNKLIHWICVPLIFLSIVGLLWSVPSDNLRFVLGTGPFNNWATIALFVTVLYYMRISFPLSIGMAAFSVFCLWSVRLIEMNVALPLWQVSLIIFALAWIGQFYGHKVEGKKPSFFKDLQFLLVGPAWLMHFIYKKLGLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E076</accession>
    <name>A0A654E076_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybutyrate coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cat</name>
        <name evidence="3" type="ORF">MARINOS108_11228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="265"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="46399" checksum="F40DB7CAC0DC605B" modified="2020-04-22" version="1">MRNSMSASEAVRNIKSGDHVFIHTAGATPNVLVEAMTDRHSELEGVKIYHLHTEGPAPYAKPEYSNSFRVNSFFLGANCRKATQEGYADYIPCFLSEIPLMIRSGIIKVDVALVQVSPPDAHGYCSLGISVDATKAAVDMAKVVIAQVNPRMPRTHGDGLLHKDMFTACVEVDEPLPELIGHPITPEEKKMGEFIAEMIPDRATMQMGIGAIPDAVLSCLGNHKDLGVHTEMFSDGVIPLVENGVITNKYKTRHKDVIVSGFMIGSRKLYDFVDDNPIVRMLDIQYVNDTAVIRRMPNMISVNSAIEVDLTGQVSADSIGTRIYSGVGGQMDFIRGASLSPGGKPIIALPSTTSRGESKIASFLKEGAGVVTTRAHVHYIVTEYGVAELYGKNLRERAKALIRIAHPDHQARLEQEAFERFRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A4</accession>
    <name>A0A654E0A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="33531" checksum="63869D2C09140479" modified="2020-04-22" version="1">MQAIILDEPGGIEQLQVTFVNSPKIQDDEVLVQVKAISINPVDVKTRAGKGVYGRLKDHSPLVIGWDISGVVTKTGSAVKEFEVGDEVFGMVNFPGHGQAYAEYVAAPANQLALKPSEISHEEAAVTTLAALTAYQAMIHQYPVKAGDRVLIHAASGGVGHFAVQLAKHLGAYVIGTSSAANRDFVLGLGADEHIDYRSVKFEEATSDIDFVLDTIGGENIDRSLEVVKPGGTIISIPTGLNAEVSQKAKDKGVNGFFFLVQSSGKDMKALAGLLENGYLKPHVSASFPFDEISKAHELQETGHVIGKLVVTLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D6</accession>
    <name>A0A654E0D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019860">
        <property type="entry name" value="Motility-assoc_ABC_perm_GldF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03518">
        <property type="entry name" value="ABC_perm_GldF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="26793" checksum="8C387D5B676A8671" modified="2020-04-22" version="1">MISIFLKEVNEFLDSLIAYVVIGVFLIGIGLLMWVFPDTNVLDYGYASMEPLFSLGPYMFMFLIPAITMKSFAEEKRSGTIELLQTLPFRDSQIIMGKFLAGFFLVLFSVLPTIIYYYSLSYLSNPVGNLDTPGIIGSYIGLVFLGGVFTAIGILASALTGNQIVSFILAAFLCFFFYAGFDAVAEINLWADWSYYIAELGIMAHYTSISRGLLDFKDVVYFGSLMALMLLFTQLTLGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H3</accession>
    <name>A0A654E0H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="8151" checksum="8F268DB450655901" modified="2020-04-22" version="1">MKVLNANSEDQLFSAIRKDSTSALEFNAKSIKLITEHPEGSYSLTSTKDKTQLVISDKKLFWKSTNYLVVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H6</accession>
    <name>A0A654E0H6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22804" checksum="36E1CB8F80C036EA" modified="2020-04-22" version="1">MRRLVWFVFVFLAIGVGIYPILYFVVGERVGLLTAKSTAVLENQIWWVAFYIHISFGAFALLTGWSQFSKKIRAKNIQLHRVLGKIYLISILFAGTAGLYLALHANGGWIAQVGFSGMALSWLTTSILAYLAILKLNIEHHRIWMIRSYSLAFAAVTLRLWLPFFDIALGMGFDDSYTIISWLSWVPNLFVAQYFINRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I1</accession>
    <name>A0A654E0I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">lon</name>
        <name evidence="13" type="ORF">MARINOS108_120389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="625"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="755"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="389"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD16830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="823" mass="92632" checksum="0BED1F579A5C2272" modified="2020-04-22" version="1">MFEDNITNRLYFSEFLEDESGELIQLVADEDGEEMTDDNLPDELPILPIKNTVLFPGVVLPITVGRTKSIRLVKKAYKGDRIIGVVAQNNTKKEEPVFNDLYKIGTVAKILKMLVLPDGNTTIIIQGQQRFELGEPVKEEPFLKATFRILKESDEMSEDEINAITSSLKEAAYKVLKLNPEIPKEAQVALENIQSYTFLTHFLSSNINAEVSDKQKLLETNNPKERAELLLKYMLKDIQMLELKHEIASKVHSDIDQQQRDYYLRQQMKVLQDELGQDGPDQEVNALRDKAKDKKWPDEVKKHFLKELDKIGRMNPAAAEYPVAMNYAELLVDLPWEEGTEDNFDLKNAKKILDKDHFGLDKVKERILEYLAVRKLKNDLKGPILCLYGPPGVGKTSLGRSIADALGRKYVRMSLGGVHDEAEIRGHRKTYIGAMPGKIIQNINKAKSSNPVFILDEIDKVSSDFRGDPSSALLEVLDPEQNSTFKDNYLEVDYDLSKVLFIATANSLDTIQAPLRDRMEIIDVTGYTLEEKVEIAKKHLIPKQRTEHGLKAKQITFDKSAIAKLINDYTRESGVRSLERKLAAVIRNVAKSIAMEEEYQPKITEGEVRKILGPEDFDKDAYEDNKLPGVATGLAWTPSGGDILFIEASLSRGKGKLTLSGQLGDVMKESAMTALSYLKTNAASLDIDYRVFEHYDLHVHVPAGAIPKDGPSAGITMLTALASVYTQRLIRSKLAMTGEITLRGKVLPVGGIKEKILAAKRAGIREIIMCERNQKDLEEINELYIKDLKIHFVKTVQEVTEIALLSQKPKEPMNFILPETARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z2</accession>
    <name>A0A654E0Z2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_140006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024954154" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="41"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2344" mass="253160" checksum="FE566E40AAB04CE8" modified="2020-04-22" version="1">MSGALALKLEKINSPMKALHKLQHLLISGILALSTMVVQAQDFTEDFDSGLPPSTGSTDLPLKSGDWGRTGVQSDETGTKTRDASADAAYILSGSGNFLITPKLFNASDFSFWYRVDSPGADGFVFDVLASSDGGTTYDIVIADNQTSLSTSYVEFTHTFESIYTGPIKIATQIEGDSHGLIDDFSANFTTSFSENFDSGLPPSTGTSDLSLVSGTWKRQGVQSDEAGSSTRNGSTDAAFMFSGGGNYLQSPSLTDVEFVQFWYRVNTNNADGFVFDVLGSSDGGATFDITLASEVTTFDQPYKRFVHEFGSPYSGPVKIQFNGIGDSNGLIDDFVAGAGAGPVPDIAFITPGGSEELKFGEVMTIQWDNSSLVGTDNYTIYYRKVGAASWTTLASRTGTQLATGTGNEMSYAWTVPDFGTDLDFQAEVRVVNATQSWDEVSPEFRIYFESSLAISSPTDTDERKFKETMDITWTNGDIGTGDYYQLFYSNDGAAFVNFYSGYIYNLTNDGAESTYTWTIPDFGADSASQVRVRVVNATRAVSDTSEAFRVYYEPSVTISSPTDTDERKFKETMDITWTNGDIGTGDYYQLFYSNDGAAFVNFFNGYIYNLTNDGAESTYTWTIPDFGADSASHVRVRVVNATRAVSDTSEAFRVYYEPSVTISSPTDTDERKFKETMDITWTNGDIGTGDYYQLFYSNDGAAFVNFFNGYIYNLTNDGAESTYTWTIPDFGADSASHVRVRVVNATRAVSDTSEAFRVYYEPSVTISSPTDTDERKFKETMDITWTNGDIGTGDYYQLFYSNDGAAFVNFFNGYIYNLTNDGAESTYTWTIPDFGADSASQVRVRVVNATRAVSDTSEAFRVYYEPSVEITSPVAGEYVLQGSTKKITWTNGDIGTGDYFQLFYSNAGGSFVNFYNGYIYNMTNDGNKSTYNWSVPAIEGTNIKVRVVNATRAVSDTTQSFTICTTCPALAVFYPNGGEVLGVGKTANIGWSVGTAWEDTDEVLIELSLDGGATYEASSVFSGTYAELSGNEFAWTVPDLVTTQGLIRVSNVTKETSDESDAVFTITRPPAAPTNFTATENSNGAVTLSWTDNADNETSYRVQYSSDNQSWINYSGFLGADTETYTAGVSVNSAYWWRVEVASGTFTETSESRFAGNILPPGKALSFDGTDDYVELANPTNFDFGTGDFTIEGWVKSNNVTSTQVIASDYSGGASFFVFYMGAGQLKASLSNSTADLSTPAVLENDTWHHVAMVRSGDVLTLYVDGVASANVSGMSSRSLASASNVELGRQASGSPFYLNGALDELRFWNVARTQGELASASVSTLTGEESGLVAYYRFDHSAGSSLADYTSGNNQGSWSGAGGANTTAQWVTSGATISNDPVITLSTPNGGEELTVGQEYEITWTTANISGADIIEIRFSGNGGESYEMIAEGTFEGFGNSYLWTVPGTMTSTARIEVANTSENVSDASDADFSIVASQLGVTVLSPNGGEFWEIGTMQVVSWEAVEFADTDLLEIRLSTDGGETFSVLGEGTSSSFQNNQLTVEVPEGASEMAIVEVANITQEVTDASDEPFTIGTVDRSITVTSPNGGETWEGASSQTISWEVMNKEDADLIEIRLSTDGGETFAILNDGTFGTYPDNTFQWTVTDTPTESALIAVVNTSRNIGDTTNAVFTITPAPDIVAPSFTNSSGGSVVGDDYTIEVTLDEESTVYLLILSDQSSIPNATQIKEAATGVNSFQGQVAVAQLEYVTPAESATLAGTGTFVRNSLYDFYLTAEDASGNLNAGLGKPNVKAQLTPLESDSVIISSIYDAMDGADWTDIADDWINLPLAQREEITIEEERITGLNLSGKSVTGVLPEVVTGLDALKTLDLSNNQITGLPNMSGMSGLTSFLVADNALLFGALEPNSTLFSEPDDYAPQAVLGEKDSVAIPKGSSYMMSHDVGGINTSYQWSVDKFNTYAVDFGDADGGTSSSYTIEAIDFNNMGRYKLEAQNSLLPGLSLVSEPVQVWATATLDITVIGENDALLSSGKAYALRNRGPGLPYDSIPKGASGGGDPNGLAIVAGHALFEDLLLGNYLVGIRADPAKFLPTYYTNTYLWEEADVLEFQGDLEATMQMTVLPPALGPGDGDGSIFGGVESDFDEDGDEGGRVNARRKVKRAGCSMRRFVRSGRQLQDGEWKLIAYVESDDEGRFKFDFMPPGTYRFNIEYPGIPMDPNSFVEFEVGEDGGNNSIELQAVITEDGIFVERINTLGFTSEQLDQMNVYPNPASNQLNIDYTTLHRGLVVKMIDLSGTVIYQQQISDQGERLELDTYALKNGMYFIHVTDPGKPGEQITYKVIIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E157</accession>
    <name>A0A654E157_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoU rRNA methylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="20378" checksum="1AC644D5E65C6D3F" modified="2020-04-22" version="1">MRKLKNEELGRMEQEEFQQSKKLNACIILDDIRSMNNIGSAFRTSDAFRVEKIHLCGITAQPPHRDINKTALGATDTVSWEYHEKISELIPQLKAQGYHIVSVEQADKSTSLLEFAPSKDQRYAFVFGNEVFGVNDEVVKSSDMVLEIPQYGTKHSLNISVSLGIVIWDFVSKRGGFPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E179</accession>
    <name>A0A654E179_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trk system potassium uptake protein TrkH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trkH</name>
        <name evidence="11" type="ORF">MARINOS108_140163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="485" mass="53780" checksum="C99993AE7689C0A8" modified="2020-04-22" version="1">MLFNYRVIINILGTLLMLNGMFMLSCIPFSLYYKEGDLFSIILSATITASFGFLMWFFTKNSKNKELRKRDGYLVVTFGWLIMSFFGSLPYILSGSIPNLTDAFFETLSGFSTTGATILTDIEAVHKGILFWRSLTQWIGGMGIIVLTVAILPILGIGGMQLFVAEAPGISPDKLQPRIKETAKRLWFIYLGLTLTETVLLWVGGMTFYDAINHGLTTMATGGFSTKNASIAYYASPYIQYVIILFMFLAGTNFTMTYLVLHKKFRKVFQNEEFRFYSGFCLVAGLVIGIVIFSQGHDTFEKSIRDSLFQVVSIITTTGFITADYTSWTPFITILFVVMMFFGASAGSTAGGVKIVRHIILVKNSLMELKRQLHPNAVIPIRLNGKAVSREITYNILAFIMIYISIFALGSVVMGMLGADFNTAIGSVATCLGNIGPGIGDVGPVDNFASISAPGKWVLAFLMLLGRLELFTVLMLFTPYFWKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E194</accession>
    <name>A0A654E194_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="5954" checksum="576A289A0E852D4B" modified="2020-04-22" version="1">MRFKFNACILHGGVPSLTIEGNLMDRKLRIGYRNNELLIRFKTLNQTPFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D2</accession>
    <name>A0A654E1D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="378" mass="43649" checksum="5008B7F91F26FEBB" modified="2020-04-22" version="1">MKTFYNLLIISLFILLISACSSGKKALQKGDYDKAVAQAIHRLRGNDDHKKAASTLAKAYKYAVESHLSNVERAKLSMDQLKWEPVVSNYQSINYLYDEILRCPGCREVVPNPVKYDTELATAKRNAAEARYQLGMAALNQKQNRQKAIEAHQHFSSVQYFVPRYKDVEDKLQEALYHATLKVVVEPIPTPARMFTIRHEFFVNKINEYLHNHVISEYVRFYTPDEAQAQQLEFVDHIIRMEFDQFALGNVFSNKVTREVSRDSVLLSDEGRAPVYGTVKATVTVHEKAITGTGLLDFKILDNDLNKVISQEKFPSEYTWAVRWASFNGDERALTDEDKALVNKIELPIPNPQWMFEEFTAPIYDQVINKMRVYYRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D3</accession>
    <name>A0A654E1D3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="242" mass="27644" checksum="2B9B462617533BB9" modified="2020-04-22" version="1">MRPKHAIFPSVYDRYTIFCPIEELEQKFSVKSQSPYKESYNAAPAQRLPVITNKKPGQIQYFHWGITDTMANNKSISPRLFNLTSDNALQRPAYKKILQADRCLILVNGFYVWKQLSKKQRVPYFCYYKYQLPFAIAGVWEEFDDLQGNVNSTFNMLVVPSSEPLQDYQEDMPAILNSEQAASWMNDDTNLSQLGEILDNIAPGGLKMHAVSPRLTDLKNNDEGLVKPAPPADQFGNYTLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E8</accession>
    <name>A0A654E1E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="25386" checksum="FF8E69AD1937918B" modified="2020-04-22" version="1">MKNDIRVIIPAFNEQNAVGLVVDEIPKSWVSEIIVVDNGSSDDTFAQAVRSGATALRENRRGYGQACLRGMEHIANSTTQPDIVVFLDGDHSDYPAQLPELVQPILSGEVDLVIGSRALGQKERGSMTPQQVFGNWLATTLIRWFYGVSYTDLGPFRAVRYSSLMAIGMTDTNYGWTVEMQLKAAKLKLRTLDVPVNYRQRIGVSKVSGTVKGTIMAGYKIIFTIFRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F5</accession>
    <name>A0A654E1F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23854" checksum="939F06A30A0DD671" modified="2020-04-22" version="1">MRLTVTSISVIIILLTSCSKPETSREPHRQGLTERGKKANHDKAITYSLITVEIGTPKSQVNVAEEHLYGKFFGDRAEFYIVENPELYVSNSQVNRLTLYFIDGMLCKKKYDLESDISQELMKSYGSFKFKALNDSTRDISKSEKIVLKTDGSARINEHLNRFQMKWDQEEVLIKYLIFKDSVQAEIHLVEELSAYKYLLDQAEANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H4</accession>
    <name>A0A654E1H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine kinase</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="270"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="348"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="416"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="659"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="777" mass="89337" checksum="147B3A9CC3EB7CF3" modified="2020-04-22" version="1">MFKSLYKRLSSRPHGNLLREEHNRFIEYIKSFEAQGIWNENLDNRIKSLAKESFDSQLNRSAGLYLLFEHSFIYKQKNPSKYQTQLRREMRGRFPNLVDTLFFRIIFSSVNNQERDLAYLIVDLVWSKYTDMVGNSKNELLKNYKYQVDKAAEQLKFNQLNRSEFRSTVKYEVSRLYEYLCLSMGQAKISEWLQEAYQLLADNYQFLDGFSLLIGILPEPLLNEQQLSQLSREQIHGVLLEKTEKLEETNQKLQIQIAEREKIQRELAQSAERLYTVVENAMDAVVLLDASGRITFWNNQAETIFGWSSEEIIGKKFSEHIVPPDRKEILDRGLDFFLKGQKMPTINRRFELVGLSKEGKLIDLELSIGANQIGDEVIFTSFIRDISDRKRYEKQLMDARDKAQKASQTKAEFLSTMSHEIRTPMNGLYGTIEYLLSENPREDQRESLKMMKHSAKGLLVILNDILDLSKLEEGHVEFDQRDFSIQELCNRTISTFMQMADEKGINLTLNLHQPIPGLIGDPVRIGQILNNLISNAIKFTDEGSVELSVECLGTSNDSVNVRFKVIDTGTGIAQADQERIFHRFTQIDNYGKTHLRTGTGLGLSICQKLLQLQGSDLQVDSSPGKGSSFFFQLSFPKSTQRIAQHPTPDDQKRDLSGVRVLLAEDNQINQIVAKRFLVKWNCEVDIADNGLIALDLLAVNQYDVILMDLQMPEMDGFEASRAIRNHKDSHMKRIPIIALTADVFPEVKEKALQSGMNDFMSKPFDSEKLYFTIASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K8</accession>
    <name>A0A654E1K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34520" checksum="4CBB4E0BF6356147" modified="2020-04-22" version="1">MSTFSIRDLEHLSGIKAHTIRIWEQRYELIKPKRTDTNIRFYDDQDLKLILNVALLKENGVKISKIAEMTHGDMQREVLKLTELNLRYPEQIHALTISMVDIDEERFEKIISTNILKLGFEKTMMNIIYPFLNKIGILWQTGAINPAQEHFISNLVRQKLIVAIDGQYTVPADKSKKYVLYLPEGELHELSLLFADYLIKSRNNKSIYLGQSLPIMDLEAVCDIHKPDYLLSVLTTVPGPSDVQGYVDHLSEKFSNCQILLTGYQVIGQDVQAPENVTFFSRFDQMIDFVESHTLTLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N0</accession>
    <name>A0A654E1N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ORF">MARINOS108_140021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="69"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="352"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="457" mass="49900" checksum="632DBF30ABE109BD" modified="2020-04-22" version="1">MAKSKTTFYCQNCGANSAKWVGKCPACGEWNTYVEEIVTKGSSTEKEVWEDASAPRNQPRKIQDVVYDEHQRIKTPTGELNRTLGGGIVPGSLVLIGGEPGIGKSTLLLQMAIRMKTTKVLYASGEESLDQIRMRAERIGIQAENCFLLAETSLANILNHAAQLKPEILIIDSIQTLHTETIEASVGSISQVRECAGKLMKYAKQTNVPVFLIGHVNKDGAIAGPKVLEHMVDTVLQFEGDRHLSYRILRTSKNRFGSTSEIGIYEMRETGLREVTNPSEVLISPRDGFLSGVGIGATLEGNRPLLIEVQALVSPATYGTPQRSTTGFDGKRLNMLLAVLEKRLGIRLSAQDIFLNLAGGIKVNDPALDLTICAAVFSSFDDIAIPSSICFAAEVGLGGEIRAVNRIESRITEAAKLGFKQIYLSKYNVKGIDTSKFDIEVKAFTRLSEAFEVLFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U2</accession>
    <name>A0A654E1U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin Phd_YefM, type II toxin-antitoxin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11740" checksum="AF5D03FFC8698A18" modified="2020-04-22" version="1">MEDIVYLYHYGTLNNIDMLVISSREFRQNQKMYFERADQGEQIIVQRGKDKSYALTPIGEEDIYFNAEMVKRIKESMDQVESGKTKRITTPEQINDLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W0</accession>
    <name>A0A654E1W0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">MARINOS108_20249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16625" checksum="717D0D7A7AD84E32" modified="2020-04-22" version="1">MPNINYFSEDVDFSLQHEEKISQWLEDIASSHEYRIETINYIFCSDDYLLDINKTYLEHDYYTDIITFDNSSNHHLIESDIFISIDRVTDNAKEMGIPFEEELHRVLAHGLLHLVGFDDKGDNHKILMRQKEDACLSLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D7</accession>
    <name>A0A654E2D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="13822" checksum="9B26B310A3D2696D" modified="2020-04-22" version="1">MIKSKKVKIMRKITLTILLGIAVAAVASVSPLTWKSTSLDLGSVKVGTSQAIAFEFTNESDSPVYIQEAKGSCGCTKVEFPKEAIAPGATASITASFQSSKVGVFKKNIKIKTSSSEAYTYLYFSGEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I7</accession>
    <name>A0A654E2I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carotenoid 3,4-desaturase</fullName>
            <ecNumber evidence="5">1.3.99.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtD</name>
        <name evidence="5" type="ORF">MARINOS108_20120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.37" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="489" mass="55120" checksum="EEA0A8EAE014F444" modified="2020-04-22" version="1">MGKKIGVIGSGFAGLSAACHLAKAGNEVIVLEKNSTPGGRARQLKMSGFTFDMGPSWYWMPDVFERFFEHFQKTPSDYYELQRLNPSYRVRFEEESIDLPASMAEMEALFEEIEPGSSLALRKFLKQAAFKYEVGINDLVYKPSRSLMEFADRRLLTGLLKMDVLTSMSKHIRKFFKNEKLIQLMEFPVLFLGSTPENTPALYSLMNYADIQLGTWYPKGGMFKVVEGMVTLAESLGVKFHYDEAVTSVNIADKNITHLVTSKGSHGVDIVVGGADYHHLDQHILPEGYRNYSPKYWDTRTMAPSSLLFYIGVDQPLPNMKHHVLFFDEDFKQHAHEIYNDPKWPSKPLLYTSVTSKTDDTVAPAGHENLVILIPVAPDLEDTEAIREKYFQLAMDRLEAFTGTNIRDHIVVKKSYAHNDFVADYHSFKGNAYGLANTLLQTAILKPAMKSKKLTNLYFTGQLTVPGPGVPPSIISGEVVAREIAKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I8</accession>
    <name>A0A654E2I8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisH</name>
        <name evidence="11" type="ORF">MARINOS108_10260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="35"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="22509" checksum="9A983CC74C2E3317" modified="2020-04-22" version="1">MGRFLFVHSMKVAIVKYNAGNIQSLTFALNRLGITPVLSDDPQILLTADKVIFPGQGEASSAMRSLRAAGLDQVLRQLKQPFLGVCLGMQLMCTSSEENDTQGLGIIPEKVLRFADPSVKVPHMGWNDITDLKSPLTQGIDEHSYLYFVHSYYVPLSEYTIATCAYPQPFSAALHKDNYYAIQPHPEKSADAGMKLLDNFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T0</accession>
    <name>A0A654E2T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="15428" checksum="7FC44057106A3AFA" modified="2020-04-22" version="1">MSKQKDKSQISILIHLASMDGDIDDTEKELISRIGMAHGLSEEELQEYFDHPLEKIDFSKLSEDESFDTLYNLVHLMKVDGKIFDEEISYCMNMAKKLGYPLEAVMDLYSQVHANVKLKSEIQKIKRKYHKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T4</accession>
    <name>A0A654E2T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025055196" evidence="1">
        <location>
            <begin position="21"/>
            <end position="2827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2827" mass="311289" checksum="E08BCDAB79BC4C8C" modified="2020-04-22" version="1">MNAKSSMFLMALLCTHLSFSQEQSSAGKIVDTNTFSVGGVDAGSLQNSVNLFSGEVNLPVSLISAPGKQGLGINVAISYNSNVQHQAQTINEESATGVLGLGWTLSYPEIVVDHKNTGNVEDDQYYLKDGSLTELIYTGTESYYSKDRNTTYTAEVFKSKNYTNWKIRYITSRERWEITKEDGTVYIYGDQYTFPSSIPWVVKWGNWIGNSNVTSGQSQMPRAWNLSKIINRLETDYVIYGYDKVESKVGGSSGLLHTEACYLSTIENGLGYDVSLTYSSKNSYEYYEPHRENPTEPDAYQEIYEKKYLVDVRLNLNGDLIQTVTLNYHPLTELSSDDRYKKRLLSEIRSSDRFGSYTTQASFEYYTSGTYIGALQTVLTASGASISYTYQTKSVGDLDLPIYAPAGYSEPQIWQGPGYVVVCWRELNGVNHDNSDRPVKVYVYEWDGKWKENFITTIQGVDRDALGGDRYQEFFVQTQKDFFGIATPGTGGYCELFLVSKNDLTGGWSLYSPQVNIGSSKPSFVSGDNFVGVGQRAEGSSTSSKLTVYIKNNNMNSWRSAVINNYSGTRDPYHIGQSNYIFTTYEIGDYNYRDIHYLKRDKTFANKQTYDGNDSWNAQMGIASNNFVALKYSNGKAVIYQWDQYFNQTMTQLGTGFSNLMRMQSVNNSIVQASDYYQSKIDLGRFNGQSWITYSEATHNDVWRSSLNDDFFVWSDNSGGYDGFRMEFNPNTNSWKTRTQLPEHPSYPNDGLTVGSFWGNYSYYWPYLHKRSNTGIWNNTFYTSELSDTQGESSYVYGSPNFFFHEQSDGTGLYKYTLHNGEVEKTYIDGTYHSGFFANEAGGLGVFVTYGSSDEWSATSLKLHKVIRHSVGGALSFYPVKYISVNDGFSTISTAYNFTTSTATITPDGRSPQFNEATTLLGTTSTTTSLNGKVISYFYNGEVLADEHLTNVNSKSPFVRGMSYKTIALDAGNAEVSKTESYFTRKSLSITNALGQMIQTAELILPTQTKSTVEGITSIVTYDYNVLNQPEATTSVNYDADGNSDVYKQTQKYYWQVYSTTGLSDNLLSPVIQQTSLVNGVIQGSSVTTWSGGLPFRSYSQVASGSAFNDWTNSGTIPSNWQLVGEMVCDSDGRVIEAKDALGVWSSTLYRDDMPVLKAYNAREDEIWSADFDDGTFGGTSTWYTPVSGGNWSVLSGSAVFDQSTTTGMMYTDLSGQFDGDYIFEFDLTFEHNATNGSVEINWDKTSSADGYVLTIDFDGKVTLFDGASELATNVTDFNLSKWQPCRLVKSAGEIHVYIGNEKVLRSAVSERSGSRVEVWANQIACAFDNFRAYPEDAYVSSFSYDPKTRSVIATKKESGSTNYYAQDENYATYAHIDHNLNPGGSSANYLPGKYGLSVSSSNPIIGLQSASSGTEGFYEGFDFNLGRWSASGGDWTFEEGGLTHFNNAGASGKFILDLPEDVTGKRVAVEFLVKMPSYYTGGSGKLNFGFGAGSSTWDGNEGTSGNAVFNEFMYDGSGFDFLLYTTPRDVNMKMGKTYKVLTILDFETQKVDCYVDGKYIITESFRSGASNVGKFVFFNRGDYGYSTPWTVDNLLIYSDPSLSATFVDASGKVRQSQSELPDTKVMVSGVFYDNLSRPYVQTRSLALAGRLGYKSSFASWNSSTKQLSGDITAEYGALAYSASVYETSPLGRVLESKIPGNDFVLGGVRTTRMTYGTNGDAGLNFDNEIGFDVDLPDNFYRASKVVNADGLESFQISDLSGNTVLTKAGSVKGIKYEAQNFQLSSSQSTHSFTAVRDQTIDYGYYGTSFKVGTSGPGSSNIVNNTVGYGSFTFQATQGVTYYVTYAGSYGGSITYDTKDPNADIYLYSRSTYDDVSNISYYYPPNYFDQGLSESERNSFVATSTYNFIGQVTESKDAESGITKYKYDAYGRLRFLEDAKGRAQGYFLYRKYDALGKVIEEGYINSGFTSANPDNQAWPATPATWRKKYTYGNHENTTYDRDMLIQVEVNNDDDNAAEVTESYDALDGEGYQNAVRTKIHGEGVAMPIIVYSRNNSGQIVQVEYTKPVDQLIGEIVTGTREVQAKEVVLSGTRVESGGDLSVMASNSIVLKPGFWAKTGSSFIASAGVAAIDEAAIVYDYDLSGRLISIGSESNPNEYAVYVYGNNGALSQEILNNETLPINYSYYSDNGWLASIDVPSKFTESIEYTTNAYGSPSGYYSGNISKVTHTYPSGLGIENYSVRYKYDKLGRLLAADNSRYHENDIGVGGDMFYDRNGNILTKRVQSTNWNYSYIAGTNKVSTLTGSGTLGTYTYDNVGNITSNVTDGLSNITYDKGLGLTTSIDLSGEMTSFQYGANNQRLLKKDQEGANTFKTYYVHGDADYPLVEIKDDGVTQDVSKYIYGPGGIIAIAKEGNWSFVIKDHLGSTRAVVDASNAYTAGYNYRPFGRPFKKVGTEEVAYQFTGQEYDQETGLHNYRARLYDDELGRFYAVDPAGQFHSPYVGIGNDPVNGVDPDGEFVTWSIGNGGFSVGFNLTPIGIPLGAGLNVGWQDGFSAGPYGEVGYRVGGNGLGAGAAVQQGLNYNFSNGNLSTSTTGLGYGSFGPFTAGGSVSYNYDITNNQWSNSWGVNAGIGLSNYDGSGGIGIGVGYGSGGFSYGLSGYYAPENRIGTRANAKAFWRENSKDLIAYQDPCPTCPSGVSIKDLDWSVQMAVSAGGTPMFDDGGNFMGVQMSNGKFIPVNNNVTDFENFASLFALGVTSRAPLLSFRKINRGFIFNGTRVQVHEHSLNALKGQGSGVIKAWHMNVGNTHIIFNPQHWGTLTPYWWSPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T5</accession>
    <name>A0A654E2T5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="112" mass="12276" checksum="20676AC0DBF4A4BE" modified="2020-04-22" version="1">MASTISAPSPTCLTECRCSHVFRKKGSFLPISTKLQLAASSDTSVISLIHCCLKRRKFKSRATQSPFSHPSNLSSFTGGNGGFKDKKSCSVKPDFTTRQEACTRVLTSIRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W5</accession>
    <name>A0A654E2W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="7317" checksum="6CDFDD171EC1A0F0" modified="2020-04-22" version="1">MYVFVHRRKLIGKQRLISVFNNVFFQVTDDSFGAFNQLLFSHVFHICEVLYHKTDSFIHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E306</accession>
    <name>A0A654E306_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="23383" checksum="F387338D838AEA4A" modified="2020-04-22" version="1">MTLLFACTSLYGQTLHYDVIRNDKSMGQTVVKRILKGDELTYHLNTKTELRVIFLFDIEYDLKETFKNGKLISGTGFNTLNGSVQKETQMALKEKFYELVIDGIRTEINETSITESVSEIYFEEPHHSKKVFSAYFGRYLNFEKVGERQYSLTSPDGTNVYTYENGICTKVKVTRDFATFEFILKPESLLAVRNKQITGKTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E321</accession>
    <name>A0A654E321_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_5" evidence="1">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="568" mass="64472" checksum="1159FE6F0B894ACB" modified="2020-04-22" version="1">MKQLLSVFLIIIILDLFLHSCANPITPTGGPKDTIPPSLISSLPLDQSLRFKEQSIEMTFDEFINADKLKQNLVITPITEVKYKTLVKKQTIWINFEEPFEDSTTYTLNFFDGITDITERNPAENLVLAFSTGDYIDSLSIFGTVADLFTGTITKKITIGLYKLSDTLDFKSIKPTYFTTSTDEGTFKIQNIKANPYRLMSFEDANKNLLFDPASEQYGFLSDTLRLTETSADSLHIPMVNINAANLKLISARPSGRYFEIRYTKPINHYTLSTADSTYLPSTIVGEKETIRVYKTETVIDSVQTFISVTDSLKNERTDTVYVKFRESTRKADEYKVTLSPKSNTSVFPHQRYTIEFNKPSKLIKDNFLSIPIDTITTLDFKPQKVQFNHNFTSLTFSLDLTAAHFRDSLTHYLTNHPLDSTALDSVQASINQKLASLSKDQFTLSITPQSFVSCEQDTSVNITQNYKFGKNENVGIIRVKLATTAPSYFVQIINKQTPVKSIRSCTECVFTEIPPGNYWVRVLVDSNNDSQWSPGNILTNTEPEPVIYFKEETTLRANWDIELNYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E329</accession>
    <name>A0A654E329_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S1/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="PTHR33146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024934952" evidence="6">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="28946" checksum="5D079A3ACB28D66C" modified="2020-04-22" version="1">MKKTILLLLLISFSFQALPWGKTGHRIVGLIAEKHLSKKARKNIEKILKTETLAEVSNHMDFIKSNDAYDHMSPWHYATIPDGMTYDEAGTPEEGDIIQTLNRLIAELKAKQFTDEDEAFALKCLVHLIGDIHQPLHVGNGEDKGGNDVKLEYFWSSSNLHRVWDSGIIDGQDYSYTEYVEWLDHASAEEISAWQSAGILDWAAESVSYRPQIYDLPESKKISYQYDYENLELLNKRLLQAGIRLAGILNEIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E337</accession>
    <name>A0A654E337_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative cysteine ligase BshC</fullName>
            <ecNumber evidence="1">6.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">bshC</name>
        <name evidence="2" type="ORF">MARINOS108_20350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BshC family.</text>
    </comment>
    <dbReference type="EC" id="6.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01867">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011199">
        <property type="entry name" value="Bacillithiol_biosynth_BshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10079">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012535">
        <property type="entry name" value="UCP012535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03998">
        <property type="entry name" value="thiol_BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="519" mass="60099" checksum="6A33C59009F9BE27" modified="2020-04-22" version="1">MKLEQVNLEETECFSSIFIDYIQQKEALKPFYDTFPTVPNFQSLIEKRQLPMSHRTTLVSLLAEQYGPLPHSEAVEFNIHSLTNQKTFTVTTGHQLNIFTGPLYFIYKIVTVINACKQLKAAYPDYHFVPVYWMATEDHDLAEINHFNLFGKKYEWSTAQTGPVGKMKPHSLNELIDSLPEAVPLFEKAYLDHDRLADAVRFYVNELFGDQGLIVVDADHKNLKHLFAPVIKKELFENTSNELVNATSQRLDAAGYKNQAFSREINFFYMENGLRERIVREGEQFKVLNTDKVFSEPEMIELIEKHPEHFSPNVIMRPLYQEVILPNLAYVGGPAEIAYWLQLKDVFDHHEVFFPALMPRVFGLIVNKANEKKVQKLKLSGKQLFQSAHKLKEMYLQKHGENGYELNDERKVMNMVFNRIKSKAEEIDGSLTGFIGAEGAKTFKTLENIAKRLKKAEEQNNETAMSQIDNIKEKLFPGNGLQERHDNFLNFYLNNPGFIPELLEKFDAFSYRFHILHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B1</accession>
    <name>A0A654E3B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane fusion protein, multidrug efflux system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="63"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="39567" checksum="8258252AE5FC9C60" modified="2020-04-22" version="1">MLSRNIQSCSLIAGITLLAACGEPQPSGMQAPPAATVSVTTVQARAVSYYDEIPANVKALQEVELRAQVSGYITGIYFKEGDQVKKGQKLYTIDQQQTQANYQQALANLSVQEANLAKAEKDVERYRELDKKDAIAKQQVDYAEATYEAAVKQVEAARAMVSSSQTNVRYSTIVAPFDGTIGISQVRLGASVSPGQTLLNTVSSNDPIGVDIAVDQREILRFSQLLNSSAADTDSVFQLVLGGEIYPHFGTLSFIDRAVDPQTGTIKMRIEFPNPEHVLRPGMSATLRVASYAENAITVPFKSLTELLGEFLVYVVQDDKVSQQKVAKGRQIGMDVIIESGLKSGQTIVVEGVQKLREGSTISIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P0</accession>
    <name>A0A654E3P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="66" mass="7489" checksum="21A255CCE35FC2C0" modified="2020-04-22" version="1">MTLLRVHDHQQDLTNDFVKMVRTTIKKGNSVAANKQQIFMMGQEMGFCNDEIRVLLEDAVPSALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P7</accession>
    <name>A0A654E3P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="272"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="768" mass="87424" checksum="BE052E2B2A7F7799" modified="2020-04-22" version="1">MLIGQLAVTGQDFNLSGTVVDERGEEIIGAGVLLEELGLGTSTDLNGKFKLFAPKRNYTLIVQYLGYKEYRNTIYLNRHIDLTVRMESTFTQLQEVVKTARAEDYRIKSIPGVERLTIKDVEDVPLLMGELDIVNSILLLPGVSNAGEGSTGFNVRGGKVDQNLITLDGSEVFNSSHLLGFFSIFNSDVIKDFTLYKGHMPATFGGRLSSVLDVNTREGSYEQMEGSVTVGPVTSKLSFETPIIQNKLSVLAAARFAYPNWVIGQMKDYDVKRSKAVFDDQNLILGYRINDRNKVNLSFYRSFDRFRFSDDFEFNWGHVMGSLTMQNVISDVFLHELKINHVDYHNRQYDVAEDYEIQNGIASTSLKDNFLYEGFTNHQINMGLEIKDYHQKPEERLAGGRSGVVPAHVEKDRGVLGSIYVDDEWALGKLTLSGGLRYNYYVMLARNEFLLYELGQPKSLTNIVDTAHVSAGDVNYANLEPRVGLNFLMTPNISLKASYNRVYQYLHLISNTTSATPIDLWQVSTFHIEPQQSSNYSLGMSFTNDRRRWQNSVDVFYRDISNIYDYRDFADLLLNNHLETELLQGQGRSYGLEFLFEKQKGKWTGWLAYTLSKSENLVNGPSETERINDGKWYPSNYDQRHNLSVVAKRDLGGDKAFFSVNMVYNSGRPFTGVESSYYFNNAVVPLYSSRNKYRIPDYVRFDVGLGFNSVFKKWEDQLNFSVYNLFGRANAYSIYYRKPTSTAIIPFSYKLTVLGQAFPSITYTVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E408</accession>
    <name>A0A654E408_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7057" checksum="0F7C45F67832D7B5" modified="2020-04-22" version="1">MNNNSGAWEVFIRFKSKDIDTIPWVTSGKGGAIFTDEVRYNGKIVDLVPCETSIPLRSTLIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E482</accession>
    <name>A0A654E482_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15673" checksum="4B1804F1E8C6F0BA" modified="2020-04-22" version="1">MLRVVSFLKLLSIILFLIILVLVYAYLPIMVALEPGAGSLQLHKETFFYYVVAGFVIVNLVMLAFQKLFEGKIENEDVKAWVRGGAFVINICLTLLVGFIGVLNNSAHLNASGFAYLNYLGPALIFSWILGLFYMIYKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F9</accession>
    <name>A0A654E4F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster biogenesis protein NfuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="SSF110836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nfu_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21382" checksum="3A737C3087A4DFA9" modified="2020-04-22" version="1">METTVNPINIYTESNPNPNSLKFVVNFLLLPEGVSRDFPDRASTTEAPLAAELFDFPYVKRVFYMSNFITVTKDEGVDWHEVKGEVQNHIKSFLEAGKQILTEKEVEEDHKVLDGDTDIEAKIKGVLDEYIRPAVEMDGGAITFGSFEDGKVKVLLQGACSGCPSSTITLKAGIENLLKRMIPEVQEVEAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H5</accession>
    <name>A0A654E4H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_40001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000009">
        <property type="protein sequence ID" value="VXD20462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="36290" checksum="C8ABC3381C325607" modified="2020-04-22" version="1">MDVDNGGTPLTIPNTDGTGRPNYIDTDSEDDNIPDFEEGFYEAGPTNYQTSYINRVTAYNAANAATSNTLYPTGDTSPADGTPDYLNDSDGDGIPNLLDPQSAYFLDDDGDGLINLFDPNQNGDFYGNVNGVPDRDDDGTPNILDGSDVPLPLDFIAFSGTVQNENVNLKWTTANEVNVSHFDVLHSTGGSKDFKVIGSVQAVNIKELVNNYQFTHQNAPDGYNFYRIREVDLDGYEGFTEIINVVMEASNISWTIYPNPAQDHLSIRSTVIIPDSRVMILDVTGRTIYDQHVSFESKEAILDLSKLGAGVYHVIIELPDSKKSFRVMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M7</accession>
    <name>A0A654E4M7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="18089" checksum="DDAF2B5AC1EE20AC" modified="2020-04-22" version="1">MFRYAKSILKETELAQDVVQECLAKIWTKRQMLEGVQSPEAWAMRITRNQCYDWVKTNRFTVISDQEMDQPNNDSADYQALMTDQMHWLEKVLDTLSPKQREIYHLREIEEMPYQEIAEVLSLNLSEVKVSLHRARTKIRSSMEKIESYGVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X2</accession>
    <name>A0A654E4X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="292" mass="31748" checksum="BF59DD8C6630A62D" modified="2020-04-22" version="1">MKRIVLLLKGMAMGGADVIPGVSGGTIALITGIYEELIHSIKSVDAVALKLLLKLDIKGLWQRINGAFLVNVFAGVLISIFSLAKLITYLLEVHPIPVWSFFFGLILISAYFVMPRTRGWADYLSLFVGAVLAYLITSLTPGDTPEELWFIFISGAIAICAMILPGISGSFILLLLGKYEFVLGAVKTFDLSIIVVFAAGCAVGIISFSKVIHWLLLHHKGVTLSLLAGFMVGSLNKIWPWKDESGDVFVNLSPNDFTTVTDQPNQLYLAIIFFSLGIIIVGGLEWLGKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E517</accession>
    <name>A0A654E517_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="25377" checksum="E1658AF27EB9F4FE" modified="2020-04-22" version="1">MSTHTALIVGATGLVGKHLLDHMLTKTYYSKIKILSRRTFEIGDPRAEVIVLPDFAEMNSISEQLHAEDYYCVLGTTIKLAGSKENFKKVDLEYPLMLAEIAQKSPEFRQYLVVTAAGSNADSPLFYNQVKGQLEEGLKQLHLRGLKIFRPSLLLGERRDFRLAEEFAKAVSKIFSFFMVGLRGRLWSINALDVAKAMHIVASEGKEGTRVYSSNDMFKIVNTQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E534</accession>
    <name>A0A654E534_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family ferric uptake transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_21000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="152" mass="18051" checksum="5D66E5CD674BCF10" modified="2020-04-22" version="1">MIVFEEVKNIFTKYLEEKGLRKTPERYAILEEIYSRNGHFDVESLYISMKNKNYRVSRATVYNTLDLLVECELVTKHQFGKNLAQYEKAYGYRQHDHLICTDCNKVMEFCDPRIQNIQNTVGELLQFDVMHHSLILHANCKRENCENKPNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D9</accession>
    <name>A0A654E5D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024653">
        <property type="entry name" value="Peptidase_M10/M27/M57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12388">
        <property type="entry name" value="Peptidase_M57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024971453" evidence="1">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="279" mass="29466" checksum="BC2BD60ADEBE1D7E" modified="2020-04-22" version="1">MRKTNYLAVFTLAVSMLFVSCEQQNDAVVAQDEVSESVLAALTNAGFDVTQQAPIKFDDGYLVEGDIYIPAADLASLKEGTRLAVEEQYSTNNLVSTGGSRTITMYAPEGGRNGYSSGMIAGLDLAISRYNAQNLAISFQRVTSSSNADIVMTRLKKGEERQGILGSAGFPTSSGDPYGEIKMSGILESSYGLSTAGIATIIAHEMGHCIGFRHTDYFNRSISCGGSASNEGTAGVGANHIPGTPTGATAAAKSWMLACTDGGDRPFNNDDRTALNYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F1</accession>
    <name>A0A654E5F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ethanolamine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eat</name>
        <name evidence="6" type="ORF">MARINOS108_60036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004757">
        <property type="entry name" value="EtNH_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00908">
        <property type="entry name" value="2A0305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="440" mass="47253" checksum="FD7A779CB5E54ED2" modified="2020-04-22" version="1">MADQNPQTPQLKKTLGPLMLWGLGVGYVISGMYFGWNLGLAEGGTLGLAIATFFIIIMYLTFTFSYTELACAIPKAGGAFDYADRALGKKLGFLAGMAQNVEFIFAPPAIAAAIGAYFNIFFPQVDTLYIAILAYLLFTGLNILGVRAAAIFELVITVLAVLELLIFAGVCLPHMKVENLTLNALPNGFQGAFAAIPFAIWFFLAIEGVANVAEEAKNPQRSILIGFGSAIFTLVVLCLLTFVSAVGVDGWESIVYPPGSTEASDSPLPLALAKIVGDSHLLYHLLITVGLFGLVASFHGIILAAGRSTFEFGRVGYIPKSLGKVHPKTLTPANALVVNMLIGIVALLTGKTGEIITIACFGALTLYIVSMFSFFALRKNEPDLARPFKVPLYPFFPACALIIASLALVAMTIYNLKLALIYGLIMLAAYLWFLFTEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G8</accession>
    <name>A0A654E5G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual-action HEIGH metallo-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024653">
        <property type="entry name" value="Peptidase_M10/M27/M57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12388">
        <property type="entry name" value="Peptidase_M57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024843989" evidence="1">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="30576" checksum="EEA019869F1CFB41" modified="2020-04-22" version="1">MKKLNYFTACMLLASATFFACESDQVMKEETVSPEVMARLTDLGFDVTDQAPLIFEEGYLVEGDIYLTDADLARMKAGVRVPVEEQYSTNNLVTTGGNRVITVYAPEESSGGGGKGKKGGGSGGYSPGMIAGLDLAISRYNAQNLEISFQRVTSSSNADIVMTRLNKRDERRGVLGSAGFPTASGDPYGEIKMSGVLESSYGLSTAGIATIIAHEMGHCVGFRHTDYFDRSISCGGGTSNEGDGGVGANHIPGTPTGATASAKSWMLACTDGGDRPFNNDDRTALNYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G9</accession>
    <name>A0A654E5G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="5015" checksum="6631DB5FF7FC558F" modified="2020-04-22" version="1">MVVSVGLKNVKSHTGNSQFDFQKIILRKKINSGLFQPTEKQVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5N6</accession>
    <name>A0A654E5N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="119" mass="13655" checksum="18205D4423429328" modified="2020-04-22" version="1">MNRVILTLFVLVSFESMCQTPALIKYPTCAIARELAKEELKGDTINYFHFGDFRNNSQFHIKIDSLARSMGIRLAHASHQSSLDCYNEVVKSHFSDNNGIDNIWVYLNIKTDSLLNLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5V7</accession>
    <name>A0A654E5V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="355" mass="42170" checksum="7382131A78AA1A33" modified="2020-04-22" version="1">MKITNKVVYQNLDDLFNQSPVLELTDADKWVIFSDLHMGDGGSTDDFRTNSDLFTRALKEHYLPRQYGLVLNGDVEEMQRFSLRKIYKHWKSVYEVFDQFRDQTRLLKTIGNHDLELGMMKDLPFNYEHLDGFVFDYKGDNLFFFHGHQASKRFQKHNELIGFTLKYFANPLGIKNYSVAHSSKKQYKIEKRAYHYSAYRKVVSVIGHTHRPLFESMHKVERLKYKIEQLCREYVEDIANQTEAIVRSIRAYKKDLKKYYKQVRDTNFQNYVYNTIFNIPCLFNSGCVIGKRGMTCLEIEGGKIRLVHWFDGNINKKYLQKTGYQPQQIPGTDYYRMVINEESLDYVFTRIKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E637</accession>
    <name>A0A654E637_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">polA</name>
        <name evidence="15" type="ORF">MARINOS108_20198</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="327"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="676"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="919" mass="103511" checksum="51EA197227CF03B6" modified="2020-04-22" version="1">MSEKKKLFLLDAMALIYRAHFALSKNPIVNSKGVDTGAILGFTNSLLEIITKEKPSHIAVAFDTHAPTFRHVEFAEYKATRQSQPEEIGVAIPYCKKIIAGFNIPILELDGFEADDLIGTLAKKAARENFEVYMMTPDKDFAQLVEDHIFLYKPAYMGNAVDVLGIPEVLQKFDIDNVDQVRDVLGLKGDSVDNIPGVPGIGDKTASKLLREFGTVENIVANVDQLKGALKTKIETHGEQGIFSKKLATINIDSPIEFDEEGLVLSDPNPEVLKPLFEELEFRTIAKRVFGDTTAEKESGQLGLFGGAMSAPPASSKENFEEKKVSYQLVDSVEDRKSLLSQLSKLDAFCFDTETTSLESIEAELVGISFCFKKGEAYYVTIPEDQKAAQAIVEEFKVLFENEKTTKIGQNLKYDMQILRNYGVMLKGAIFDTMLAHYLIDPETAHNMDVLAENYLNYTPISFSELVGKGKKEKNIRDIDINLVKDYACEDADITFQLKEKLEPEIKEFNLGKLLHEVEEPLSYVLADMEYEGVKIDEQALAAMSKELEQESLRAQTEIFEIAGQEFNIGSPKQLGEILFDKLKLIDDPKKTKTGQYATGEDILSRLANEHEIASKILEFREYQKLKSTYVDALPKMVSKIDGRVHTDYRQTIAATGRLSSNNPNLQNIPIRTAKGREIRRAFIPRSEEYEILSADYSQIELRIMASFSGDESMTQAFKEGVDIHANTASKVFKVPLDQVESSMRRKAKEVNFGIIYGISAFGLSQNLNISRSEAGEIIEAYFTEFPKVKAYMDDVIEKARKQEYVETILGRRRYLRNINTKNFTMRGFAERNAINAPIQGSAADMIKVAMINVHNWMKKEKLKSKMIMQVHDELVFDVHKSEIDLLTTKVDEFMKTAIQLEVPMEIGLGRGNNWLEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E756</accession>
    <name>A0A654E756_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27930" checksum="B7041E2660642038" modified="2020-04-22" version="1">MITPIEKKGNITTHEDINFKLQQEFQYGALKFANNPLHKKLKGDGQVLDKLVFLPRMLFFVMGFKDLMQLVRYEQPENKLEESVNTHSDEDSYHWEWYLKDLASMSGQFKNGNSIDLITNVWDDESLAVRKTIYAFSRHMQNMTDPVARMLMVEVLEITFDKFKEAIHPVLKDADLYDRLEYFGKMHQETEENHTTGISEDEISGLIEALPDHLKAEMLLVVRELFDNMYLMAANWAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7F6</accession>
    <name>A0A654E7F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025001549" evidence="1">
        <location>
            <begin position="24"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="684" mass="76789" checksum="4656F49313A6056A" modified="2020-04-22" version="1">MKTLKKYWTKTFLLLAISGSWSCAEKETIISSGDLTLRVNHQLHTSLQSTKTDAKGLMEGFQPTEYLILSEENLTDFDLSAYEETSITTTLGEGVRHSFSGKNTATGITKQLVLTVYEAFPNFITTQVRYVNESDQPLTYKSWINNGYHLISQDEPPFWAFQGSSSGARADWIKPVNSGFYQDNYLGMNSSDYGGGIPVTDIWNRSAGIAIGHTATAPKLVSLPTEMKVNERSLRVGVREDFDYPSYLAPGDTLQTLETFVMLHSGDYYNGLQQYSEVMQAKGISLPPAEPAAFEPIWCAWGYERDFTLAEVLGTLPKVKALGIKWAVLDDGFQQAEGDWHTNQQKFPGGDEQMKDLVKTIHSHGLKAKLWWAPLAADPGSKLLTNHPDMRLYLEDWAPQYITWWDAYYLSPTHAKTIAHTQEVVDLFLNEWDFDGLKMDGQHMNAVAPDHNPLSGLEDPTLAPEKLPEFFRIIYEQARDIKPDAVVENCPCGTCMSFFNMPHMNQAVSSDPTSSWQIRLKGKTYKALIPQTAYYGDHVELSDGGNDFASSFGVGAVLGTKFTWPADNPTASASYLLTPEKERVWAQWFDLYNQKMLSKETYLGGLYDIGYDLPETHVIQKGDTLHYAFYAAAWDGPVTLRGLTADTYVINDYFHEVSLGTVTKEAPELKLKFSNFILIEAYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E885</accession>
    <name>A0A654E885_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fpoK</name>
        <name evidence="5" type="synonym">nuoK</name>
        <name evidence="6" type="ORF">MARINOS108_12097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="102" mass="11097" checksum="A73AF132ACAFC725" modified="2020-04-22" version="1">MTQIPLTYYLILSAFLLCSGLLIVLIKKNAVFVLIGIELMLNAANLNLVAFSKFDPDLNGQVFAIFSVVIAAAEAAIALAILLNIYKTYDSSDLDDLNTLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8X0</accession>
    <name>A0A654E8X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="388" mass="44169" checksum="E31C6D77E0F64AD7" modified="2020-04-22" version="1">MNKSFEDKIRDRLSEYRVDPPAGFRDAILNAPGPGEAWLVRFFHAFGAVLMLISLFMVGYIPMREQADLGLGDEGRLNSQEVVDFSGDSFSHPTIAMNDEEATPMKTSPRALESKEELITPLPHAEMRDEERYDAPHRAVFDPWDLEKLAGEEAMEPAYPTLAGGVETNEIIFKRTRRAYTLYLEGGAFFLYNRIRPNLDDDIYVSDYDAPFGLSASRVGLSVHWGLQRTWSEHFSTRLGLGFNHYNQDFSFNVRGTTPQTVVVESDFVTPIYEISTVQIKKRVSTVGVKIQNTWSFPSRYNSLFASVEYQRMISSLPTFEYEGTRHTLVDPNQYFLELGLRKLLFEGNRGLIHVTPAFKYSVTKFREMDIISVKPFSVGVSVSYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA41</accession>
    <name>A0A654EA41_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="14291" checksum="C8BFE088114D72D9" modified="2020-04-22" version="1">MFEEMNLREIDLFFEAQEEPNKGCMLALRQFLLAFNPHITEAWKWRLPFYLYKGKTFCYLWTDKKTKMPYVGIVEGGKIAHPMLIKGDRTRMKILPIDPNSDLPVEVLEEVLEEARTFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB85</accession>
    <name>A0A654EB85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019288">
        <property type="entry name" value="3'-5'_exonuclease_PolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10108">
        <property type="entry name" value="DNA_pol_B_exo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_B_exo2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="27990" checksum="F48BA1E42DD11559" modified="2020-04-22" version="1">MDQRLKNLLILDIETVANSKEYHKLNTDLQRLWEKKANFLRNEEELTAEELYEKRAGIYAEFGKVITVAFGIFHEDQGELNIRIKSISGHDERQLLTEVKNFLETKFDPEYLRLCAHNGKEFDFPYLSRRMLINGIKLPYVLDNAGKKPWEVNFLDTLEMWKFGDRKNFTSLDLLTTIFDIPSSKTDIDGSMVNEVYYTKEKGLERIEKYCQGDVIATAQLFLKMHALPIVDPKNITIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBP9</accession>
    <name>A0A654EBP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="271" mass="31750" checksum="491DABBE93B63848" modified="2020-04-22" version="1">MKYNQVIAIFVGIIVSSCGGTDQTARQEKALPQFQNKGHELIYQMTQKVGDYETLWNKKDVVYTYTYRTSDGKADISTEKYLFDGELSYGLYQTHERTFPDLEGPIEQGFDGQEYWLKHNGQIQNDTNRLKSVAFNRPTNFYWFAMFQKLMDPGLNYEYLGEETIDDTVYDVVKITFRTTDDKLTDVYQLYINQKTALVDQFLFTVADFGAMETPYLMKLEYEQIEDLLIPTQRRYKKSTWDAEVSDEPWISVIWSDIQFNTGLSSKDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECF3</accession>
    <name>A0A654ECF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6499" checksum="58170D1F2D4BFE93" modified="2020-04-22" version="1">MKLLDYILFSLAVAFFVMGIYETMVLGIGHAYGIFMLSLGLLFLFGYRKSRREQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECW0</accession>
    <name>A0A654ECW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdA</name>
        <name evidence="9" type="ORF">MARINOS108_20497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="131"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="387" mass="42053" checksum="8D6494FF55584926" modified="2020-04-22" version="1">MQLLTDDPRIKQEEENRAMISEMIRDFGAKEIEPFKMEWDESQEFPRALFHKLGKLGLMGVFIPHEYGGSGFGYHEYVTAIIELSKIDGSIGLSMAAHNSLCTGHIYQHANESQKQKYLPLLASGEWLGAWGLTEPNTGSDAGNMKTVAKKEGDEWVLNGAKNFITHGISSDVAVVIARTGEAGASRNASAFIVERGTPGFSGGRKENKLGMRCSETAEMIFDNCRIPAANLIGEVGDGFVQSLKVLDGGRISIAALSCGIAEGALDVAVKYSKEREQFGKPISSFQGISFKIAEMATKLEAAKLLTHQAADLKNQGKSVTKAGAMAKLYASEISVELANEAVQIFGGYGYTKDYPAEKYYRDAKLCTIGEGTSEIQKLVISREVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDJ7</accession>
    <name>A0A654EDJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloramphenicol acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008811">
        <property type="term" value="F:chloramphenicol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001707">
        <property type="entry name" value="Cmp_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38474">
        <property type="entry name" value="PTHR38474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00302">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000440">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01059">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000440-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="214" mass="25431" checksum="105A7C3FA8606996" modified="2020-04-22" version="1">MSVKSKKTRVDLTSWNRSEHFHFFKEFDEPFFGITTHVDCTKAYHRSKNEGFSFYLYYLYQSLRAINESTSFRYRMESEEVWLYERIHASTTLLREDKTFAFTFVPYTDTFEEFVQAARLEFDDAMNSTGLRMSESTNRADVIHYSSIPWFPFTAISHARAFKFEDSIPKFTFGKFQEENGNKKLPVSLHVHHGMMDGYHVGQFLELFQQFLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDM8</accession>
    <name>A0A654EDM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alpha,beta-D-heptose 7-phosphate 1-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="335" mass="36075" checksum="59840BCA28ACE457" modified="2020-04-22" version="1">MAFDSIEGVFNAFTKMKVLIIGDSMVDTYTYGEVHRVSPEAPVPILQAQKTEHRLGGAANVALNIQALGAHPILCTLAGADPEADLLIQLLEQQRISAAQVVKSDERVTTVKHRVLSGSQHLLRIDRETERSLTAVERSLLTAIIEPLISEVDLILLQDYDKGCLSKELIQWIIRAAQECSVPVVVDPKKKNFLTYQGVSLFKPNLSEMKTGLGLEALSLDESSLADGATLLSGKIQFDQLLLTLSGEGVYYYSDAVSGKLPAHLRSISDVSGAGDTVISIAGLCCALNLPLLFTAELANLGGGIVCEYPGVMPIDPIRLLGEAQSNELLLAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEC0</accession>
    <name>A0A654EEC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13177" checksum="43FD41A23D99E03B" modified="2020-04-22" version="1">MRTCIIVEDEIHHQDLLSFYLKKTGGVQVLGMYTDTVNAAIQIEKQKPDFIFLDINISGLEGPEFIDLLEHRPKIIIVSAHSEDFMAAHYSEIPYAAFVQKPIDLIKLQEALAHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSN5</accession>
    <name>A0A654DSN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025033764" evidence="6">
        <location>
            <begin position="23"/>
            <end position="3542"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="814"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="2028"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="3542" mass="390254" checksum="C29EC517B01D60B1" modified="2020-04-22" version="1">MKTKIITASIVVLSLIANVLGAQEIRKATESEISTYKEQLSKKTEEHRTDLTANPSANTTNVAQSTPKAQEQTSAQKIEEKMALENTDKSIEYRELALERVIKEFNEKKQKPMQDVGQPSFERVTPKSAEDLKESGDVFLEDEDLKALKLSIHQKNIDDQKRLIENGFGSANERTSVRNTKAAEVKPTSTKDDSWYQSLTGGSQSHNMGTWADREEELKRQARERSQQRVTRDSRQAERISFQADSTVTSDSLALVDLYFALNGDFWYDNSNWLSGPVNTWAGVDWASYEYEEVGDTSSTFKTVVFVTGLTLYDNNLSGALPASIGDLDSLSYLNLGYNSITGDLPAEIGNLTKLSYLDIGGNFFTSLPGTIGNLTNLDGLSIWNRTYDNEGYFVTDGMTDLPTSLWTLTQINSLDLGGHQLSSIPGELGNLTNLGYLWLWGNALQSLPTSIGNLANLEVLYLDGNQITSVPSEIGSLTKLRELNLGQNQLTELPEAIGSLDSLRYLYAHNNQLTSLPTGIGSLPKLEYIGLWHNFLTTDISDFFGLSTLQSLVIYDNQLTGTLDGVSGLTNIHELSIGSNQISGSIPPEIGSLTNLNYLWVDNNQLSGSLPAELFELPAIQQIDVGYNQITGEFPVTSGTESLYQLRLGGNGITALSSGIGNFPGLVSLSIEFNEISGSLPAELSGDTSLVYFYAYRNQLSGTIPESYSSLTHLAELVLDDNLFDGELPTAIGSWTEMSLFSISRNGFVGAVPASLNNLEFLQELWIDNNQLTSLPDLSGLYSLSGVWAYNNYFEFDDFEPLMQTYAGFNLGPQYIPEPTFEIVSEGTEVLIDATVGGSQNHYQWYFNGEWLNAGDTSVLVISNLNRESAGTYWCEIYNDSVTNQTGLHLYSGDQTYWISAPVSPGDSLALVDIYKATRGRDWYNANNWLKSPVAMWEGVFLKDGRVTKLDLYDKNMQRGLPPSIGDLDALEWLSLYYNPGLQSIPGELYSLTNLHYLDLDITGITKISPSISLLTNMDTLWIGGNNYETKIPVEVFSLTKLKVLEMAGAGFRGAIPNEIGSLTELEALWISNMPKVRGDIPASMASLSKLSFLNLSGTPFTGGLENIAGITSLKSLFLYNSPLALTTLPSSLSGLTNLESLNMSGGDFSAGLPAVIWEFNQLKRLTLAYMQITEVPAELSALSLEYLNIGNNSITGGLPADMNVDQMKYIYFHNNEIDDISVLENASLLETLIGYNNRLDFADLTPLVSYFENNQGFFDVSYQQPLPVSSDYIQLSVGESLNLSVDITPDSITYIDWFHNGSYVGSGTTFTIDSVTNPHSDGYYEAYLYHDVISSLAGLQLYTPPVEVQVVEAVLEADSSALVAFYNTIDNSSERLYNWLEGPVETWEGVEAYGGRVYGLSLYGLEGSLSGTALSGLDALSFISIYGGNLAGGIPAEIFSLPNLNFIDLAYNNLSGSIPLEIGNASQLGYIGFSGNLLSGAIPSEIGQIGNLNELFLDNNRLTGAVPESFNQVQWGALGLDRNHLEDLPAGLDTALMYAYHVNFEYNQFDYEDLARASGNTVYSDYTYAPQESTRDIYFTGDATVGGTVTLHAERQDPNDEFYWYKADKNSYEPYYFEFGYTGTDSTFTFTIDSDWDQTKYMAVVRNSGYKNGDYRFLSSQLVVDPYERRFASSMSASPIEASSSGSDIGGVGAPDTPPIMEGEGWEWWLYDSWWHNAIEPDLDTLKMYYSDSAIAIDYVRLHSPGGELNVTTMTLHGTGGEKLVVPVYREIYQHENQLKFPKTSFSVNQIDFAVTNGSVDAIEIGDSGADGIDPPMLSDFYTEIGRDYLFVEVINPGFADYIVLERGTDGVNFDVIDTIGFTGWYFDAVSPGTYYYRAKAGYPTFGAESGYSNVLETGNCNPVVPLDKVWAGVSTGLGDYEGITSTRDSVFIYESWSYATFNVSDMTAGWYDQFWGYHEELGFFREKCDNLSGYSEYGQVSEVSAVYENDTLYLEWKDFGNNLHVISKFYVIGDAPENELYELYEPENVTAYLMSSASIGLTWNSSDGASEFVIQRSEGDATNFANVDTVTNQLKYADVNTLDGRHYYYRVIAKAGNLTSYPSEEANIIHKASLFEPVSNAVTEDITRTSYGGSWADFDGDGDDDLYVTNAFELAANFLYENTGNGTFKKIIGTIATTEIGFTRSASWGDYDNDGFTDLFVPFNGEGDRVYRNTGSKSFVKTNAVVATTTTDFGSESGVWVDLDNDGNLDLVTSAGFVFTNDGAGALALSATLESPDGLLPDLPILIWTVSNVDFDNDGDQDIYFTGDQQNMLFVNDGTGQLFYVENTISNDFVRSRGYTWADFNNDGFLDLITGDRNTEALGMYLNDQSGGFEFLHITALTNDYDGEDDVQFGRGYTSGDMNNDGWQDLVWTIEDRAYILYNAGNLTFDLVDVDEQAFPATNIFSHVSLADVNGDGALDIFLPNQDFNGHNYIYVNNVKTNNWISVKLKGIESNRSGIGGRVRVKANNTWQVQAVTSQNGISSGNSLRTEFGIGTATVVDSIAVDWPSGLTTYALNVTPNKFMTMVEVPVASGPTVNEGDSTALVALYNGTAGAGWIKNEGWLEGSPLAWEGANFDDNGRLVSLILNDNNLVGTIPTEITNLTALEVLDLSGNQLTGKIPEALGNMTTLYNLSLNDNQLQGTIPASVGSLVNLQNLDLYNNNFLGELPATLGSLSELRQFEIHNNGFIGFVPANIGTLTNLQVLRLDHNDFEGPLPEGLGGMASLQVLYVNDNHFTESLPATLGGLSELLQLKVQNNEFSGDLPASLSALTGIQYIDISNNLFSGSLSPLAELDTIYYLNADRNRFTALPDFASNSADTIYVRNNSLDFEGFELNASLIQDGRLLVNPQDSLFARVDSLHNVGVGIEIFFEIGGASNSYTWKFNGEVLESSDGIDVFESSVLIASPDTPNEGEYILEITNESFPDVKLVTRPFNLKLSSLERDRQALLAFKDAVDKGAFKFDLTTWTGDVSSSWEGVTVEENRVTALSLPAEIDTDLTDGDQSRILEGNVPPSFADLSGLVTLNLKGNYLRSFPNVSKWPSITAVDISNNRLAFKDIIPNLGLKNTATFNYVPQRRYDETVYDTIQAGENLQLGIQMSGTGLQYQWKFGAYIPGQPYNNDVANITGANSRVLQIESIDYSKMGTYRVEVTHPQVPDLTITSRNKNIMASTDIFGTVFADNSNTLLTDGQVIIYRRTPAGPFVSEDTTEVDATGLYGFSNVVLGDFIALARPVRSIFPNTIPTYYEQAELYADATTIEVRERIEGVDIQMIFYQDPTIIETGADFVGELFTDIEDQGIVDEEGSRVNARRKVKRAACSMRRFVRSGRGVQEDIYELYAYVESDDEGRFNFEGVEEGKYLLNIEYPGVPMDPSSDIEFIVGGDKENQLFTLTAVITENGIEVEATEVLYSLKPYIKDVRLYPNPTESILTADFLVYRKLNDLKMEVVDVKGIKLWEQALNPKMGVQSTRVDLTTYPTGVYFIVFTDEAGTFRQQVKIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSW1</accession>
    <name>A0A654DSW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28889" checksum="2DD4237E5D0403B2" modified="2020-04-22" version="1">MIKKIIQSIDRISHFVFFNATNSRKTFYELDQISYRESAQIIHQQGAGAVLLDRKDKFWTHALSHIPMKGVLLEFGVFRGDSINFFSEVLLEKKDQRKIYGFDSFEGLSEDWSGTSMVKSTFDLKGNLPRVNDNVVLIKGWIDKTLPPFIENNGLQADKIAFMHIDMDTYSPTKVIFEQTVEYLQPGSIIVFDELLGYPGWRDNEYKALMECIDPRWTYQFISFCEPRSKDRNTSKYIRAAIRILEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTC7</accession>
    <name>A0A654DTC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="52593" checksum="8689671E5B251057" modified="2020-04-22" version="1">MENLRTAFIALLTGIVILAFVHTSCTSSVGRGMEAVFITDKLYTDPPNFGSYPATKDQIQKMIDEVDLPNIRAHAWDVWGSITSPGPEGLPVWETWYSGYEVFELAGKKGIKTRNIVRDFQSPRQFHHFENITGGAIPQDLPEQITSFNRYTKSVADFIVSSGLNRTEVLDSINGAFDQAGTPIALRQIQTTPDSIDERAIVLKPVFQFIDGSGPTVIPFWNGISPKTTTDLKNPEPHTWRQGVIVDPTGVLKPGDSALMSVNNEPLRWLQVVGLEDFYAIELTEEDVKEFSDFAATSGDDVGEGNMTDSTSIYQNVKVGNYALLMAMHVTSKEINNWTWQTFWWSPYNDHPFFGADRPTSISAPWDHYNMRTAYFMVTPAGSAAGEPFVSFNPYLETNLFGTVPIKTKNGVLDSIPWTGVNSNCMTCHRLAARAPGNFNTPAYQPDGFISIGDSVFAGMTKVDFLWSVAIRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTZ2</accession>
    <name>A0A654DTZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1274" mass="141401" checksum="A74992677018B4E9" modified="2020-04-22" version="1">MLNKIIKYFLENKLVTILVLTGFVAWGIVTAPFGWKVGALPSDPVPVDAIPDIGENQQIVFTQWSGRSPQDIEDQISYPLTTYLLGIPGVKSIRSSSIFGFSSIYIIFSEDVEFYWSRSRILEKLNSLPSGLLPEGVQPALGPDATALGQVYWYTLEGRDKDGNPTGGWDLHEIRTVQDFYVKYGLNATEGVSEVASIGGFVKEYQIDVNPDALKAYNIPLHRVMQAVQKSNKDVGAKTIEINQAEYLVRGLGYVKKVQDIEKAVVAVQDNVPIRIKDIGVVTLGPATRRGILDKDGAEVVGGVVVARYGANPLQVINNVKDKINEIAPGLPKKTLADGRESQLTIVPFYDRSELIYETLGTLEEALSLEILITILVVIVMVYNLRASFLISSLLPIAVLMVFIAMHYFGVDANIVALSGIAIAIGTMVDLGIILSENIIKHIDEAPPGQKLIETIYNGASEVATAILTAVSTTIVSFIPVFTMQAAEGKLFGPLAFTKSFALLAALIVSLLILPTLAHWFFGFNIKNKFLKKYGHYGLVFVGIVSLILGQIWAGVLLILFGAIGIIKNLERIKSKKLSRIWKFLLSYAELIVVLIGVVWLLAKYWLPLGASQSLFINFIFVSLLVGCILGGFTLLEYQYKQILNWCLNNKIKFLFIPTFLIFLGATIWLGFNSVFGFVSKSFEKVGWNINQTKGWSTMVHTFPGIGKEFMPSLDEGSFLLMPTSMPHSGVEYNRKVVGQLDMLLTNIPEVELTVGKLGRVESALDPAPISMYENIINYKSEYILNKKGHRQRFKVDTDNRFITVSGDTLTNAEGLERGIEANELIADENGEYYRNWRDHIKSPDDIWNEIVIVTKLPGVTSAPKLQPIETRLVMLQTGMRAPMGIKVYGPDLKTIENFGLQLENILKEVPSVKAEAVFADRIVGKPYIHLNINRDEISRYGLNIEDVQQTIETAIGGMKITSTVEGRERFPVRVRYPRELRDDPEALGKILMPTPTGAQIPLSQIVDFEYIRGPQAIKSEETFLVGYVLFDKRDGFSEVTVVNDAQKTIQDKIDSGELNVPSGVSYKFSGSYENQVRAEKRLSIIVPLVLGIVFLILYFQFKSVSTSLMVFTGIAMAFSGGFIMLWLYGQDWFVDFSLFGTNIRELFQMHTVNLSVAVWVGFIALFGVATDDGVLIATYLDQSFERNKPATIEEVRQAVIEAGLRRIKPALMTVGTTMIALLPVLTSTGRGSDIMIPMAIPSFGGMAFALISIFIVPVIYCWREERKILKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ8</accession>
    <name>A0A654DUQ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="137"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="44749" checksum="6E6999904AEA61BB" modified="2020-04-22" version="1">MSTQITASTIEQISTRHQALELVRKMLNTTYPVALWRLPNTTDILALIDITSEERHAEAEIERLEQCFVINSYDQSHPINPLVLKGDIIINIQGPESKVTLSTTLKASDLEAFTLAIDQVELSALGRNPQESEFHPDFEGMVTEAIDHIKSGELHKVVLSRYQDFDLPEGFDPIAIFEKLDQTYANAFCYLVQTSTFGAWMGATPEKLIAIEDEHYFSTDALAGTQVLGEVEDLSDVPWTQKEIIEQAMVSRYIIECFKKIRLREFEEVGPKTVKAGDLVHLKTSFKVDMKETNSPLLGSTMLELLHPTSAVCGSPRGLANDFIRTHEGYERELFAGFLGPVGLDGNSRLFVNLRCMQLFKEKARLYAGAGITENSRPEKELQETNNKMQTLLKVIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV43</accession>
    <name>A0A654DV43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">ligA</name>
        <name evidence="12" type="ORF">MARINOS108_10878</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="604"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="683" mass="76591" checksum="B622617D57089992" modified="2020-04-22" version="1">MSTSPQEKIANLTKELNHYSYLYYQENKSEISDFEFDQKLKQLEELEAAYPEFKLEDSPTHRVGGTITKNFNTVYHKSRMLSLGNTYSKDDLIEFDKRVMKGLGTEDYEYFCELKFDGVAISLLYEQGVLSQAVTRGDGEKGDEVTSNVKTIRTIPLRLNGDYPESFEVRGEVFMPKKVFKALNEERAKNGEALLANPRNTASGTLKMQDSSVVASRKLDCYLYSLLGDAITTSTHEESIHLLERMNFNVSPTYARCKGLEEVFEYINTWEQKRHELPVETDGIVIKVNSTAHQEELGFTAKTPRWAISYKYKSEAAETRLNNITYQVGRTGAITPVAELEPVLLAGTTVKRASLHNANEIERLDIRIGDYVFVEKGGEIIPKITGVNHDRRAADSKETIYQNSCPECGTPLVRKEGEANHYCPNADGCPPQVMGRVEHFISRNAMDIAHLGPKTIEGLFKTGKISGIADLYSLTFEDLNGLKFEDKDELTGEVKIRSIKDKSAQNIVESLEASKQIPFESVLFGLGIRYVGRTVAEKLAEHFKTIDNLRNTSMEEVIAVHEIGERIAESVVNFFSIPENIELIERLKAAGLQMRVEETQTPEHQSQIFQGKTVVVSGVFESFEREELKKLIKSLGGKVSSSISGSTDFLIAGANMGPAKLEKAQNLGTQILSEKEFSEMINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVB2</accession>
    <name>A0A654DVB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoquinoline 1-oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012368">
        <property type="entry name" value="OxRdtase_Mopterin-bd_su_IorB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036389">
        <property type="entry name" value="IOR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="212"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="754" mass="82756" checksum="8DBB1812249DF401" modified="2020-04-22" version="1">MTLLKTKVGRRAFIKTSALAGGGLMISFSWLASCGPGIKEAEVLAMSDEWFDLNAYLKIGENGVTTIMCPNPEFGQNVKTSMPMIVAEELDMDWEKVIVEMAPFNTSLYDRQFTGGSQGIRRSWNVLRMAGATARQMLKQAAANAWGVPLEEITTASATVKHEASGQSATYGELVSAASKLPTPAEVQLKEVKDFTIVGNSKKNVDARKIVTGTPMYSLDINQEGMLTAMIVHPPAFGMKLKSFNADSVKDMPGIKEVFSFKTFQDDYVQNYFDTNTFPELVAIVGNSTWEVMNAKKALQVEWEPFDSYSFSVDAFGNKQTREVPAGLENSDSHLTAMQERASRPCTLLRKDGDPDKAFTSAAKVIERTYTAPFLAHNPMEPINCVADVTAERAIISAPIQAPELIEGTLSARLGLPLDKIEIVMTRMGGGFGRRAYGHYMVEAAVISQKVNRPVKLVYMREDDMTFGVYRPTYMATYRAALDENNQLVAYHVKAGGIPESPLGRGAANRFPAGAVDHYLAEEWSVNSNITIGAFRAPRSNFLGGAEQSFLDEVAEAAGQDPIQFRLDLLTRAKHNPVGEQNDYEADRYAGVLELVRDQSNLSQPRPGVHRGVAAYFCHNSYAAHVLELSRENGKLKVKKVTCALDCGIVVNPDAAANMAEGAIIDGIGNAFYGEMTFRNGVPEKTNFDRYRMIRMNEAPESIDVHFVKNEIDPTGLGEPPFPPIFGAVANALYKSSGKRYYHQPFLKEGVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD6</accession>
    <name>A0A654DVD6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrp</name>
        <name evidence="7" type="ORF">MARINOS108_10973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="39165" checksum="457C5F5449971A19" modified="2020-04-22" version="1">MEISRDNILIALSEVQDPDLKKDLVTLNMIHNIQTGEKAIKFTVMLTTPACPLKELIRKDCEKAITKHFGEEVAVEIEMSSTVTTVRQNAPMLPGVKNIIAVASGKGGVGKSTVAANLAVALAKTGASVGLIDADIFGPSVPTMFNCEFEQPSVTQVNGQNKIIPIEQYGVKLMSIGFLAPPENAVVWRGPMASSALKQFLGDTVWGDLDYLLIDLPPGTSDIHLTLVQSVPVTGAIVVTTPQKVALADAQKGIAMFRQPQINVPVLGVVENMAYFTPEELPDNKYYIFGENGGKRLADKFNIPLLGQIPLVQSIRESGDAGYPAVLKDDVTAEAFRDLSQSLAQQVAIRNASEAKTKKVEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF5</accession>
    <name>A0A654DVF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024830697" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="16459" checksum="3DD3BECDEA8B009D" modified="2020-04-22" version="1">MKTLIIGLILILLSVHGSSAQTPDREQEIIDLSKAKWQWMSDKNVEKLEELFHEKSAFVHMGGSWGKEPEINIIKSGGIWYKKADIHEVSVNIIGSTAILLNNITLIAEVGGNEVTNPFMVTEVYIYEDGDWKLGSLSFTKLLTRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVM1</accession>
    <name>A0A654DVM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="18423" checksum="E6970E4B0D0CC374" modified="2020-04-22" version="1">MALIKSVRGYTPEIGKECWLAENATIVGEVIMGAQCTVWFNAVIRGDVNYIKIGDRTNIQDNVTIHGTFEKAPTNIGSDVSIGHNAIVHGCTVQDQVLIGMGAMVMDGAVIKTGAIVAAGAVVLEGTIVEENSIYAGVPARKVKDVEGKNREMLLRIAGNYIKYANWFKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVN4</accession>
    <name>A0A654DVN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="4">
        <location>
            <begin position="504"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="571" mass="62482" checksum="C4E49D40FEEF74CC" modified="2020-04-22" version="1">MRKSSSVLKPLRASEMHDPNKVARVNLSRHLPVSLICLIILLCSQLEVLADRGRPHINSDSGFNRLLTDKNTPLRGVSLSWDGGDNATHTGAAVMPTQSQLNALSTVYGLNSLHVYLEMDCPIGGHNHVVGQNAAICDQLVEMTAQANLYLIITIGCGNNNGQIASMAWAQQFWNFYAPRYKDRTHVIYETHNEPGPYNPAAWSTSDWENQVVLYNTIRSKAPDTHIMTCSFMSFNSGREALDGIGYMRWRGVDFSNASVAFHGYETMASVDACISEFKYDTGGGMTPALICTEFDPGTSYSGFNNMIESHQLGWLEFTFLGASDGDLQWFKGAMDDNNVVWTPDYGNWPTASAGGPIGQTIGIRGSNGLYVSSENGLSPMNCDRQSPQEWEQFTVVDAGNGLIALRGNNGRYVSSENGQSGILCNRLSIGDWEAFSWVDFGNGSFGLQGNNGRFVSSENGNSEMMCNRISADIWEKFTWEVASGARVTTGEIVKLQTDAEVKIYPNPAVESFTIDAVDFDQVKVVDLSGRTVYSSLLETGQLKVSSLSSGAYVVILSSPEQTISKKLVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP1</accession>
    <name>A0A654DVP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15419" checksum="64683B34C730484D" modified="2020-04-22" version="1">MNHKHNATEPLVLHAGEGRTYNCGRMTAVFKADENETDEKYSISEWWLEPNTDGPGAHLHEENDEVFYVLEGTVSVLIGQEWVQAKKGAFLRIPAKTLHDFKNQTEKRAGLLNFFIPGGFERNMPAIVSWFEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP5</accession>
    <name>A0A654DVP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="25547" checksum="6619CBD9354F2E5E" modified="2020-04-22" version="1">MFDKFLEGNQYYDYPSFEVAIFSLLLALVLSTSIAYIYRFTNGDEFYSKSFFQAMVLSALVTSMIMMAVGNNLAVGFGIIGAVAIIRFRTNIQNPRNVIFIFAALSVGIASGVHGYAVAIAGTIIFCITAILLYWSPAGGKMSHKFEVICQSSDHELIQEVKAYLIARSKSFDELELRKRTELNNRYEYLIFLEDESHILEIFEYLQSLEGISDVRIIKKPIPEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV6</accession>
    <name>A0A654DVV6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqfO</name>
        <name evidence="4" type="ORF">MARINOS108_10853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="40423" checksum="B8591E8ED7DF49A0" modified="2020-04-22" version="1">MRIKDITDFLEQFAPLSYQESYDNSGLLVGDANAEISGIAITLDVTEQVIDEAIRNGDNLIIAHHPLIFKGLKSLTGKHWVERCVIKALKHDIALYAIHTNLDNVHLGVNRKIAEKLSLKNIRVLSPKSEVLSKLVTFVPHEDAQQVLDALYKAGAGQIGQYDHCSFQTEGTGTFRPGDGSSPHIGNHHVDETVNEKRIELIFPSHLKHRMVSALHNSHPYEEVAYYLSTLSNTNQEVGSGIVGDLTSPMGASEFLRHLKQTMRTDCVRHTPICKEKVSKVALCGGAGSFLLTKAIGTGADVFVTGDFKYHDFFEADNRIVVADIGHFESEQFTKDLLYDIISEKFTNIALRLSEVQTNPINYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX5</accession>
    <name>A0A654DVX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13346" checksum="5FD3AE7828E82183" modified="2020-04-22" version="1">MSPNLDMCCELKKLPDLFSHFEEHKAKGGDTFLEFLVEDYVHHDENSSGHHDHDKDDDLPFHGQHQCCHGPVFMTLFQYFPEIENFCLTNQVKVSTYSFSLCSEYCESPFQPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ4</accession>
    <name>A0A654DVZ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">bVLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="bVLRF1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25961" checksum="1A817A84FF284771" modified="2020-04-22" version="1">MDQLKANLYHLPISELMDMVKREFPHAVYDLKRHLVVLNDEHNESLGFIRLPLHLTVRKDFSIPEQAACVLYLTIESGNAAICIMHGSNNVYHTTFSAYMTRKKQGFSQIKYLNKKGKSRAGSRVRLAATTEFFEKINLTLTELLEAHQVSRVALNCNATLIPYLYQSRVPFPIDKKDPILYKIPLHIPQSNFTNLEAAIRKLRAPMLFYDPAHAERMELFMLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW38</accession>
    <name>A0A654DW38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="434" mass="50954" checksum="9304FA3444323047" modified="2020-04-22" version="1">MAEIRPFAGWRYHQKHTQNIDRLTSPLFDVVSNKQREVLYQTEYNSIHLSVPQGEHPAELAKKKLSKWKQDGVIVQDQLPGIYVYFQHFSLAGRDQTYIRKGFICNIRIYEWGEKEILRHESTMPFSVDDRMQLLHETQLNVSPTHGLYTDPNAEIEKYLDESMLAPIYESEDYQGVRDVLSVIHDAKIIGRIQEIIREKKIILADGHHRYEGSLNYMQQRRKENPKHTGQEGYNYHMMMLTNTEADDLRILPTHRVVRDLDNFSEEWLLNQLEEDFTIKTVENAPDVNEIILGKQWAFGLLIGDNAYKIRLKPEKINEIKWNFPDEVKALDLTVMHYFIFEKILEIPGQKQVNARNITFQRNFTECLREVLKGEAQFALITKDISIETVKQVCYSGFTMPQKSTYFYPKVISGFVFSSIDDHEFQTPFDSCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE9</accession>
    <name>A0A654DWE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="22486" checksum="73BFF275FE6C5F42" modified="2020-04-22" version="1">MTKTKIFTIVFGIVALCLSFFLYYSINSSIEESQRIAKMEARIIEQLKMIREAELSYLAVNGRYTSDWDKLLAFVDSGRFYLTEKTEYVITLDYGADSTYVEIDTLGTVSVKDSIFKKSTWPRFNLSTLPYVPGVEPPTKFDIWADKIEKSGVSVNAIEVKNPKPINPIRDEESEYNTRKPLRFGSKTSVTTAGNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG1</accession>
    <name>A0A654DWG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="25008" checksum="64A1108711A7F97A" modified="2020-04-22" version="1">MLQSVTAFVTLHQNNNNLKAPGHILFLIGTFGVLFGVGMLIEHTQPAGLTDEALEPDILLSNSRTYFEEDAHGRSVMHLYNAIEAIKKIEQDLEPESKEKVDRAVVQLEQILQDMSGEIFDIKKLNEASVKALNALTYAELKISEHFVESHELGKAKLALKYGMLHVKHALVFAEGAKKEYEISIYTEMDSLIESDELSDKEIIQKLERMIEDLDNLGLQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU3</accession>
    <name>A0A654DWU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="25101" checksum="02AEF3979A1FA9F6" modified="2020-04-22" version="1">MTLKELGQNLIIGINRYSPKPLLHPFRMTGPEKKLFDATVGLSDYYLEFGMGGSTFRSLGKSEADICSVDSCKEWVNMMKQYLFIRRMEKTRLNLVHVDIGPTGEWGRPLGDESRELFPSYSAEVFEQIDSEKIDTVLVDGRFRVSCVLKTIMECHTNKRLNILFHDFHREQYQVVLKYLEEVSMVDTLVLLKLKKEIDFDALEQDYDRYKYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW5</accession>
    <name>A0A654DWW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase-3 subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="26758" checksum="F0377B2B827753E2" modified="2020-04-22" version="1">MQEYLLFVDTETSGIPHSLKSPISELDKWPFILQLAWAVYDRAGQLVKQENHFIYEDDISIRPSAIEIHGITLEELKEKGEDRKAVMRQFTKDLRQYKPLLIGHFMEFDGKMLQVALLRSGMKNIITRYPMFCTMKATTEYARHTDHNYPKLDELYLKLFGKRMEHQHDAAADVAATAECFWVLYHKGELTEKILAAQPIYTQMKSKAKAKMGCGLPVFVLIIASILLWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX35</accession>
    <name>A0A654DX35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="136"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="5">
        <location>
            <begin position="270"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="343" mass="39565" checksum="1C3001CDA7B9D284" modified="2020-04-22" version="1">MKKKILIIEDQLEVRENIEELLLLSHYEPITAPNGKEGVKKALEHKPDLILCDIMMPEMDGYEVLYLIGKNPEIASTPFIFLTAKAEKTDFRKGMNMGADDYITKPFEEMELLGAIERRLEKFSRLSSNESLQEFVTRAKEYHELKDLENSGKTRSFKKKDIIYRHGDFASYAYKIKKGKVKTYQINPDGKEFILDVLSDGDFLGENALIQDTERTEFAQALEETELILVPRKDFQDLIFQNREVSGQFIKMLSKNLLEKEHGLVEMAYDTVRKRTADALMKLFNKYEEDHFDVSRSDLASMVGTATESVIRILSEFKKDGFIKIEGSTIHVLHPEKLSAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX64</accession>
    <name>A0A654DX64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21692" checksum="6719578F1652AE67" modified="2020-04-22" version="1">MEDYFEEQAFNGVNFTEQRLKKGEYNRCQFTNCLFSGVDLSYLVFSECVFENCDLSNARLNSTSWKEVQFNECKLLGLIFSDSNPFLMAMNFRGCQLNFSSFYQLNLKGSQFQQCSLHEVDFTETNLTGASFHQSDLSGAIFEQTILEKADFRAAQNYSIDPALNKLKKARFSMPDVVGLLYKLDIQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE7</accession>
    <name>A0A654DXE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="69" mass="7427" checksum="D47C46439C97834B" modified="2020-04-22" version="1">MLSYSFDLAGQPVNNNLPNLPATGVSHGLSSLTHTSPKVRHPLFQPKGQRLGGMWQGEALASTLVNHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH8</accession>
    <name>A0A654DXH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="225"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="477"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1129" mass="125206" checksum="01268FE85AD19F23" modified="2020-04-22" version="1">MKYIFQTIIMVTKYSMYTFMVLVLTMSSILADSVTGQVKSVKDVFIKLNVPEGSLDEVLKDIERQTNFRFFYTDKSLGENVDLSLSRKRAAVADLLLEVSGQTGVHFRQVNQTISISKAKGQITEPIEVIINKQTDVSGKITDEYGDALPGATILEKGTTNGTISDVEGNYQLNVSEGGILIVSFVGFQTIEVPLEGRSVIDVRMQPDFTSLEEVVVVGYGSVKKSDLTGSVTQVDMKDVEDIPANSVEGILQGRAAGLQVINSSQDPGAGATVRIRGGSSLRGSNSPLVVVDGFPWGGAGGLSQINPADIQSIEILKDASAAAIYGSRGANGVIIITTRKAKTGKTTVNVRQQVTFSEFSSRLNLWRDPALMARLSNEAAINGGFNPQYIGAENNIGIYYPSIAEIESGEWPHNTQWDEIVFRDRPVSNNTTFSVSSSNPTTTFNLSGNYYTDQGVFIDDDYSKINVNLNVGHQVFDDLKVTVASIVNRGNRNNNGGLAYWRNPLLPVYNEDGTYHRYNNNDFDHPIALTENRLNKTKTLDVLSFLDAEWEIAPSVKVTSRLNYKFGSSLQDQYDPPIYTLNGQNNNGAGYIRNWQEQTLVSETFVNFNKTLDIHTFGITTGWSYQNDRYRGTNLGAFDFVNSNLQNENIGSGNPEQNEVSNSFQESTLMSGIFRLNYTLKNRYLLTFTSRADGSSKFGSNNKWAFFPSGAISWKAHEEAFISQLGVFDQLKFRGSYGISGNQGLSPYETLSRFGLSEYYNNGQWITAIGPGREVGRTGQDGIEVLWGGIPNPDLRWETTAQYNLGADMGFVGNRVKVIFDYYVKNTHDLIQSRILPLSSGYDRMLVNQGSITNKGFEVTIDAGVVQKEDFNINTTLIYSRNRNEVTDLGTVEQSGLSIDPNTGMLYQFYGNSIEMYRDNPNLLAVGLPVNVFYGYKTDGIVQTLEEGLDAGLDGDDADPGEYKYVDINDDGVIDNNDKTVIGDPNPDFTASLNLSASYKNFDFSIFLNGVFGNDVINTQAFNQPNNRPFRWTPDNPTNEFPSLRDGRFNRFSDWWIEDGSFVRIQNLNLGYTIGMPGNISARIFMNASNVFTFTKFEGYDPEVGLDGRYWGGIPRLRKWTLGLNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV5</accession>
    <name>A0A654DXV5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">MARINOS108_11902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="36860" checksum="19D6386C5E08BCA5" modified="2020-04-22" version="1">MDNTKTILVTGGAGYIGSHTVRLLAGLDYHIVVLDNLVYGHKEAIVNDSVELVQGDIGDEDLLQQLFKKHQFSAVLHFAAYAYVGESVSDPHKYYVNNVARPLTLLKTMVDHQCLKFIFSSTCATYGNPEYVPLDESHPQNPVSPYGKSKFLLEQMIKDYETAYGLKYVFLRYFNASGASEDGLIGEDHNPETHLIPLILDAITGDRAAIKVFGTDYPTPDGTCVRDYIHVNDLGDAHIKALEYLNKGGESLACNLGTGFGYSVMEVIKAAEEVTGMPVPYELAERRAGDATELVANAKLALEKLGWDPRYKEISAIIQTAWNWKTGTRKGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX8</accession>
    <name>A0A654DXX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="8891" checksum="045148154D45EC68" modified="2020-04-22" version="1">MGDQKAKSNARRKGNRHQTSMLEYFKILLRKLSFNSRLFRKEYRKTFRYLEPSDQDRLREWLRKGPENTKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE3</accession>
    <name>A0A654DYE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="44633" checksum="F9D5A74F1342BC7F" modified="2020-04-22" version="1">MNPIMMRTSICVMTLCLIASCGMQNEERSVDPILDHCVSKVTASANSLTETDRMPRNIAPGKKEWNTVSVRDWTSGFWPGILWYAYEHSGDESIKAQAEKFTEQLEFIAHSPADDHDIGFQIYCSYGNGYRLTGNEGYRQVMLKAADTLATLFNPTVGSIHSWPSKKQWPHNTIIDNMMNLELLFWASKNGGSKRLYDIAERHAETTMQTLVRPDFGTYHVGVYDTLDGHFIQGITHQGYADDSQWARGQAWAIYGFTLSHRETGRRDFLKTAKKLADVFLKRLPVDGIPFWDFDDPAIPNAPKDASAACIAASGLLELSTQLEDPTEKEKYQKAATTLMKKLASDDYLSKDSNRAILLHSTGNHPKGKEIDVPIIYADYYFMEALLRLKKLGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN3</accession>
    <name>A0A654DYN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024832325" evidence="3">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="395" mass="44823" checksum="870B7F3C1504EC9A" modified="2020-04-22" version="1">MNRILLMCGLVGMWMSACNQGGAQPEDTDVENTPTTVSDSGLSARIANLLDYPATAGSFPRSLEPNGQIRGVASRDWTSGFYPGVLWYAYEYTGNEAYKKLAQEWTALVEDQKTNAGTHDMGFKINCSFGNGYRITNDPKYREIMVESAKTLSTRFNPVVGCTRSWDFNKDVWTFPVIIDNMMNLELLFLATEFTGDSSYYRMAREHAITTMENHFREDNSSWHVVDYDPQTGAVRGKQTHQGYSDESSWARGQAWGLYGYTMVYRFTGEAQFLDQARKIYTYMMDHPSLPEDLIPYWDYNDPSTGKPRDVSAASVTASALYELSTYVSDPKMIEQADAILEVLQSEAYLEDGTNNMFILTHSTGNMPKDDEVDVPLIYADYYFMEALLRQKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR0</accession>
    <name>A0A654DYR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="832" mass="92998" checksum="713ACA3E8E31385A" modified="2020-04-22" version="1">MIIRISSTFLILFFTTVLFGQGQADYSSGAIIQRLEKLNTLGSVLYMAAHPDDENTQLIAYFANGAHFRTGYVAATRGDGGQNLIGPEIRESLGVIRTQELLAARSVDGGEQFFSRANDFGYSKDPDETFRVWDRDKVLADFVWAIRQFRPDVIITRFSREPGVTHGHHTASAILAMEAFEKSGDTTVYPEQLQYVSPWAPAKIFYNIGLWAYRRSGRVFNDEGYLKLDVGQYNTHLGKSYTEISALSRSMHKSQGFGSSGSRGADFEYFEQWGGAETDQALFEGINTSWSRVADSEEVAYYLAEARRNFDTAQPANILGELLNARKALLKMPDQFWKEVKLAELRETILAITGTYLELTSEKPFYVPGDSIRITLEVINRSHADLTLSSVTLDQNDERFIYNLALENNQKNQFSYQFPLSKSTPYTHPYWLNTDATEGMYSVSDQRLIGLPQNPPALKARVSLSSEGQFLDYEVPVIFKTTDPVKGEVRSPLEIRPPVMVNLDSRALIFAGNKSKKMPVKVIAGRDDISGRVTLNLPEGWKSSPDFYEVAIQEAGGEQSFDFSLTPPEGPSNAQISAVVELSDGKKYDLGKEVIAYDHIPVQTLYPKAQVKVVKLDVGELTGRIGYIMGAGDELPFSLEQIGYQVDILDKDDVSAGNLARYDAVILGIRAFNTVQWLSFKNQELFDYVKKGGNVIVQYNTSHQLVTEEIAPFPLKLSRNRVTVEEAPVKFLKPKHPVLNTPIKLSPSDFDGWVQERGLYFPGEWSKEFVPLLGMNDPGEEEKQGSLLVAPYGKGFYCYTGISFFRELPAGVPGAYRLLINMVSLGKADKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS0</accession>
    <name>A0A654DYS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="34084" checksum="F288F937AFCC1773" modified="2020-04-22" version="1">MMNRRDFIEKTALLGSAAFLPISAFSSHKGPQYKMGLQLYTVHKDMTSDTIGTLKAAKAMGYEDFETFGFDSEKGTFYGYQSSEFKKILDDLEITASSGHYGFSAYLHQPEDDLKRFVDQCLEGARALDMKYITWPWIAPEQRTMDNYKLMSEKLNVIGEQVTSGGLGFAYHNHGFEFIDHNGENGFDVILKETDPSLVKLQMDMYWVMHSSPYTPKELVSQQPGRYVMWHIKDMDKVTRDYTELGNGAIDYVEILPDPVESGLEFYFLEQGGNYAHSPMKSVADSADYFKEHLQQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU8</accession>
    <name>A0A654DYU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24765" checksum="6A7B7418AF71AE82" modified="2020-04-22" version="1">MTAKEFIETLNIIGQEYSDTIPKREIFSLAKESKLMPVSEVVKLLNAQNHDHRLGAVSILDWKARNKGTSAEEKREIYQAYVDHHKNIDDWGMVDRAAPYVVGGYLFDKDRSPLYELARSANPMERRTAIVSTYFFIRQDQIDDTFRIAEMLVHDPEHFVQTAVGSWIREAGKKDEVRLRAFLDQFAHGMPRVALRYAIEKLDPELRKHYLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV7</accession>
    <name>A0A654DYV7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="107"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="729" mass="76372" checksum="4F75D338A632FE99" modified="2020-04-22" version="1">MKTIFSQLFYSVLNRSAFRNACRAGFLSLLFFLAYAVQGANVYVSTSGGLASACSGASSGDVIFIAAGNYTGPFVLSGKSNVTLKSYNGTVNLEGSSSTGTNGINILHITNSTNILVDGLVFRNNWGNTGNGIIVNGTGNEIDIVNCEFYNIGWTNSKTTMPTSGENAHAIVVVGSTSSAIQNVFIGNNSVHDCITGYSESITLVGNVQNFLVEGNTLDGNTNIGIDAAGHFSWTGAPASVNYARSGIIRENVVKNYAGPAALDAAGGIYVDGGSYITIENNIVFNYKVGFSVGCEVAGKSSTGNIVRNNLAYDCTLSGLFLGSNTTSTVSGTQVYNNTFYKCGTGTYDNGQIALQNNTSSVIKNNIMYPTDWRYAIVQMGGTTTTSHTLAYNLYWRDNANTSSLFYNVSGDANSVKQNPLFVNAGSDNYSISSSSPAVDAGDPSFTGSGQEDLAGNTRKQGSAVDIGAYETAGASLNITVDGATSDWSSVSTIATGGTNLTSLKAADNTSNFYVLAQGSFSTNYQVFLDTDNNSTGSNEYTSSSWSSTGFNYMIENGTLYQYTGTGSSWSWSSLGGITAVKNSSVLELSVPKSSLGISGSVVRVAVASLNSGYSMVGSIPSGTSGAAYTIGSAGSRVAVEAPVALSNMLSIFPNPATDYLRVAHVQDHEGVVVIEVMGMDGKRYAEWSELLPPGSHQYELSLKGMSKGMALVRVAANGETTVRRIIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY9</accession>
    <name>A0A654DYY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024881126" description="PKD domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="984" mass="107322" checksum="BCD4524F5B5D7B3A" modified="2020-04-22" version="1">MKKILFFFAFTAACQLHAQLQPCATVVTQRQLELLRDFHPDVRSGGRMADVPVQNVAISAHLIRRTDGTGGMTEQELNDAMDVLNDYYSHANLAFFLAGITEIHNSEYFDFNTDDEVAMGAKYDVAKTINIYFANSVGDSQGGSYCGYAYFPGGPDRVLMDNSCAVNGSTLPHEIGHYFTLYHTHGSSNSQLTDELVARVNCETAGDELCDTPADPQLGGSNVNASCTYTGTSVDANNDLFTPDPRNIMSYSLKFCRDVFTDGQYSRMDQAYDAYRSYLYKKIVSADFTQNLSEACAGTSITFYDRSLNATSWSWYFEGGIPETSTAQNPEVLYETGGVFDVQLIVSGTGGNKDTLLMEDQVLVAAVPQTILISKVARFEGSGIDLEVINEDGQKTFEQISGISSEGQKSVFVNFYEYGAVGAEDYLVLPLVDNSFSRDYRLTFDYAYTYYDDTYFDRMAVLYRGSCEADWVSLWDKSGVGLATKPAQTGSFSPTSGQWKSVSLEFTVPENLEGTEVAFRTTNGYGNNLYIDNIRLEAFVKMEATPYTCPNTNDGMITVQTSGTQNYTFSLDGETFVSDGEFGDLAAGAYTVTVKDELDRAYSESLTIESRVLNKSVQPTSCHAAADGSATFTVSGGGAYQFSVDGQSLSGNNASGLSAGIHTVSLEGTDNECILTEDFEVLSPEPLAVEVVVTDANCFGGEGTVDAEASGGSGALSYQIDEMGFTNTSTFSLGSGDHLLTIKDENECELQYFLTIDQPDSLYFTYETTGFLCAKNSSGQLTMTGAGGSGAYTFWAGEEQLSGEVLEKDEAGSYEVRVFDGNGCEFSQEITVGYQYELPEKPVINLVDGHLQIAETDADICWYLDGELMAGETGPSVVYGAGTYEVALTVGDAGCSVWSDPFVVLGLTEWPEIMIVPNPVMDQFSIKIPNDLKGGFRSVMVYDMSGQLILSSHKMEIHNEWPAGIYLLEIKGESFHLIRRIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ90</accession>
    <name>A0A654DZ90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="31251" checksum="F5E30E561C62AA9B" modified="2020-04-22" version="1">MSASITTYLKDLSYSYYLKKSSDEIAKINTSKTNLLNNLNSALGYRIKRSFVFGSYDRDTILPRSVDSNSDIDVMVIFNHTEYERTPETYRNWLKTFADNNYKSRYGSDVVKSFPTVTIRLGNIHFDLVPAKEETWGWSSSNIYIPDKSYGWQSTDPSDVKTRLTDANTRFNQIVKPIIRLLKAWNSTKGYPFDSYELELAITDMNFSGDNIESGFFYAVNSLPSSWRDPQTKQDKINSLRYNIENVKNCLARYDINSAKSWLHRVLPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF4</accession>
    <name>A0A654DZF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_110093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024855952" evidence="4">
        <location>
            <begin position="24"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="441"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="688"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="827"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="927" mass="104819" checksum="567E07037A92C8D6" modified="2020-04-22" version="1">MKLLCKVIIVVSLCALSTYFSWAGVSQNALSGLDMTRDSLRIAEVIVKVEGALKAGTLSADSASSFFYHLAKQYQEAHDFQQARTYVKRSLSALNNQENDELVAADHLLLADMAMEEDDTAIALELLFAALKIYENLEDSVNYLLTLRKVGVNYDYINDHPTALQYYEECIELAQKLGRQDVVGACYNTIASIYCTEGDEKKGIEMYEKAVRIAQETNDKVLLHKLYHNMALTYKDLEVFGEAMGYLKKSLVIAGELEDPKWFGFSYQAMGHYYYAFGKYDSAEYFMKQALAIAEEINNTQIRVNAWDVLEQVYSKTGRYKEAYDVFKLIKAEDDSIFNLQNTQLIESIKAKYQAEKHDRELAEKNLQLQEAGYNMDRQQNMQTALVVVVAMLVIISFLIYRGYMLRKRANDLLRLKNSEIESHMAQVENLNQTKSRWFVNVAHELRTPLTLIKGPVNRVIAEYDLPDEVREDLMMVEKNANSLANLVNEILDLSRLEEGEVSLNESVFSLCEQVSTIVNSFASRAEQLGVALNNRCPEDAYIKADKEKLNKLMVNLISNALKFTPNGGAVEVLVQMNKGLEILVKDTGSGISPRDLPYVFDRFFQSTDPEHQMQGGTGIGLALSKEIAEMHGGELKVSSELGVGSVFTLSLPAHMIVTKAEAEVNLNEEEVQTEVTEVLLSLDNRPSLLLVEDNKDMSSYVASLLVPHFEVVEVASAEEGLEVLRTQNIRFIVSDVMMSGMDGFSFLRAVKADPLWRHLPFIHLSALADDNLRKEALRIGIDDFLTKPFDPEELIIRVKNLYDNFLSRISINIQSDEDSYDERIMKRLKKEVLTNIEDANFNVLRLADGAAMSERQLYRYLKGATGLTPLQFIQEIKLTKAIELARKKVYSSTNELASAVGFRQASYFSTLFERRYGKKPSAFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF5</accession>
    <name>A0A654DZF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016883">
        <property type="entry name" value="UCP028431"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028431">
        <property type="entry name" value="UCP028431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="212"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="51286" checksum="6AA0140C34D444CE" modified="2020-04-22" version="1">MNNLFKIGTLIVLVIMSACSSKQKEQTATTLIREDSLLDKVQYQTFQYFWDGAEPNSGLARERVHMDGIYPSNDENVVTSGGSGFGVMAILVGIERGFIEREEAVRRYERILDFLETADRYHGVYPHWWYGDTGKTKAFSKKDDGGDLVETAFLIQGLLAVRQYFKDGNEKERAIAERIDTIWKEVEWDWHTKGGEHVLYWHWSPNYGWDMNFPVGGYNEALIMYVLAASSPTHPVTPEVYHKGWALDGNIESNETYYGYDLVLNHYEHDESKVGPLFWAHYSYLGLDPRGLKDKYGEYWALNQNHAKIHYAYCLENPEQYEGYGENCWGMTSSYSMKGYAGHRPGADLGVISPTAALSSFPYTPKESMQMLKFLYAPQRDTLVGKYGPYDAFSFSADWYLPRYLAIDQGPIPVMIENYRSGLLWDLFMSAPEVQNGLKKLGFEYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ9</accession>
    <name>A0A654DZJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024969402" evidence="1">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="406" mass="45870" checksum="619BB2BFDE46A99C" modified="2020-04-22" version="1">MRHLYSITLLFCTLSTWAQVDGSLLKKAPKDSSITGMNMDAVYNRPFLQVGKTPVAVGGYIEADYQYMGEDGLTEGHSFRIPRLTIFMSSAIHQKIKFLTELELEEGGKEIAIEFAALDFNFHPLFNLRGGVIMNPIGAFNQNHDGPKWEFVDRPLSAEQMLPATWSNVGFGVYGKHYQNDWAFGYEGYLTNGFNNSIIENDQNRTFLPASKTNADRFEETNNGEPLITLKTALRYKNNEIGFSYMGGIYNTHTEDGLILENKRRLDVWAVDFNATLPLTKTYLVGEYAWIWVDVPSSYSQQFGNRQHGGFIDIVQPVFTRTILGFNNATLNIACRLEYVDWNVGSFRETGENISDDIWAIVPAVSFRPTAQTVIRLNYRMMKQQDILGNPPAAIAGIQFGVSSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS4</accession>
    <name>A0A654DZS4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsaD</name>
        <name evidence="8" type="ORF">MARINOS108_120203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="335" mass="36106" checksum="8ACAD4D4E0D42888" modified="2020-04-22" version="1">MSTTILGIESSCDETAAAVCKDGKIINNIIATQSIHESYGGVVPELASRAHQKNLIPVINEALVAADIKMSDLDAIAYTQGPGLLGALLVGSSFAKTAAMALGIPIIPINHMQAHVLAHFIEDPIPEFPFLCLTVSGGHTQIVRVNNHLDMSIIGQSKDDAVGEAFDKCAKLLGVGYPGGPKIDQLAKTGDAKRFTFPHSDIPDLDYSFSGIKTAFMYFLRDGMKKNDQFINENINDLAASLQGTLIDMLFVKLKLAAKREKIKNIAIAGGVSANSGLRNRLLTDADKYGWKVFIPKFEYCTDNAAMIATAGYYHLQAGKTGTLRDSPQPRMSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU0</accession>
    <name>A0A654DZU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062973" description="Cytochrome c domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="552"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="638" mass="71177" checksum="6EAAE035BB4F8E1A" modified="2020-04-22" version="1">MKTLKYHFALILATLWVSLVAQPKEEDYYKIITMPVPEGILLEVGGVTTLPDGRVALSTRRGDVWLVENPYLAGGELPKYTLFASGLHESLGLAYYQNALYAAQRGELTKLVDTNGDDRADVYETIYSWPLSGHYHEYSYGPKIADDGSMFVTANVAFGDQEWWRGESRVPWRGWTMKISPSGEMEPWATGMRSPCGIGMIDDEFFYADNQGDWMGSGGVWHVAKGSFTGHPAGLRWSGESDSPVKLSQKAFFDEIDERRRFEEGRYIKPENIMDEENPLTLATAKEKFPEIRLPAVWLPHAILGISNSEILKDETQGAFGPFAGQVFVGDQGQSKIMRVVMEKVNGEFQGVAFDFKEGFQSGILRMDWGNDGSLFIGETNRGWGSAGNQNSGFERLIWTGKVPMEMKTVSARPDGFEIAFTKPVDRKLAENLDSYSGQSFTYKYHSVYGSPTINAEPLKIKGVQVAEDGLSVRLVVDNLTRYYIHEINVPGIRSADEQLPVLHPTAYYTLNSIPEGDKLPASALSTKRTSAVVPKKPAPQKPVTKLTTEVLTYEQVKPLLDKNTCSACHQVSKRVVGPAFSDIAKRRYTDKKIVELIYNPQPENWPDYSTPMAPMPQVPKEEAMKIAAWINSLKTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E043</accession>
    <name>A0A654E043_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-histidine N(Alpha)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">egtD</name>
        <name evidence="4" type="ORF">MARINOS108_120259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="3">
        <location>
            <begin position="6"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="36209" checksum="89A9565232B7E3E5" modified="2020-04-22" version="1">MPLNQFARDVKEGLSSSPKRLSSKYFYDARGDKLFQQIMHLDEYYLSRAELEIFQTHKEALLTIMDHGVPFRLVELGAGDGLKTKVLLKHFLQQGVDFSYAPVDISPDVLEHLQENLLNEMPTLKIEPLAGDYFKVLADLKFKNHTHSVAFFLGSNIGNFLSDTAIAFLSSIHDNLQKGDYLMIGFDLKKDPKRILNAYNDAAGVTRAFNMNLLDRINRELDANFDTSMFDHNPIYDPMTGQCRSYLISKQALEVHVGALNETFSFREWEPIFMEVSKKYDLEEIQELAGKTGFRLVQNFFDQEHLFCDSVWEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E051</accession>
    <name>A0A654E051_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024925422" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="5">
        <location>
            <begin position="121"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="4">
        <location>
            <begin position="419"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116042" checksum="4949251D70DC533A" modified="2020-04-22" version="1">MRLRYTKKGQFLKTLFAVLMLISVNAFGQGQTISGKVLDENGEGLPGATVVVKGTTSGTTTDIEGAFRLQADESSVLVISFVGYEPYEVTVGNQSIIQTSLKPDVSSLDEVVVVGYGEQTKETVTGAIEVVKGKEVFASRAQTNPALALQGQTPGITVTRGSARPGQEDIDLQIRGFASINQDPPLIMIDNVPVLNAREFYSMNPDDIESISVLKDAATAIYGARGANGVILVTTKKGTRGELTVNYNGNFRMQSVGLTPHAANMREYGQLWLEANEEMPEEGRNYWGFGTAEKIQLLADGYEGPLTDIYFAWDGMYVKDVDRIEEFFGNSYSQQHNISVSGGNETTRYRISGLFADDVGALKPAYDGQKQYNLRFNFDHQLSDRVNLSSGITYQKRRRSSPSNGVDGRSFQQNPWIFPSKNDEDQYVAAFGVIGSENFLASVESGGREELDEDLTKINLGMTAEIVEGLTLELTGSYNRRVQSTDESNIDIALYDWDGNFANYTSQIPEGITDSYVENDYLNYGSYLNYQKSIQGHNFSAKVGVTGDYFRSEGNSITRNGYFEDNGIYDINIAPQTNVQTEGGQGQWGLYAYLSRIAYDYKGKYLFDLVGRRDVSSRFAEGYKALNYAGVSAGWVISEESFLKGASFLSFLKIKASYGETGNQAGIDQFSYLSTVAPSRQLFGASPALQSSASIPNIIDPTVTWERINMTNFGTEFSLFDFKLSGSFDYYLRNNSGMLIAVEYGSIMGNDGIGPLTNSGDLDAHGWEAALGWKDRVGDVTFSVSANMSDSRNKIVRLDGANIPVLNTEGINIEGYPIGSLFLWETDGFFQTQEEVDAYYSTYSGSFPNQGNTGLRPGDVIKVDRNEDGVITSENGEDLKFMGDLSPHYTYGVNLGAGWKGIDFQVTFQGVLDQNIYRQEGNLSAPFAGSRFANQTAAFLGKTWTESNPSAEYPRMTWNTALARHNWWDNEWFLQNNRYMRLKTLIVGYTLPKSLTQKVAIDKARIYFSGNDLFEFTAIKDGYDPESRGSSSNIYPFMRTYSLGIDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A5</accession>
    <name>A0A654E0A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="31050" checksum="3CAC960FF590ECB9" modified="2020-04-22" version="1">MEAVLERFPFAYYHIALRYFVAAGLAFLVFYVIFRKRMPLRKIQERFPKAKDYLRDAGYSLITVAIFAVISIWSFKVLKPYHLLFDSFESMPAWYWPLTVIPMFFIHDFYFYWAHRLMHHPKLFKQVHKVHHLSTNPSPWTAYAFHPFEAVIEALIITILCFTVPTHAAIIVLFMIFQIFYNVYGHLGYELYPRGFNKTWIGKYVNTSVAHNQHHHKFQGNYGLYTLIWDRVFGTLRTDYNDAYDQAATRRVPAKETVLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C1</accession>
    <name>A0A654E0C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15277" checksum="FAA43F28A4EB4514" modified="2020-04-22" version="1">MEDMIINHWAVIVAALANLVVGALWYSPALFYKAWKSENQLTDDQLKTVNPVKLHGISTLLSLIICYNLAFFLGDAKTDWVWGTTAGFLAGFGWAAIIFAIIAMYEFKSWRYILINGGYITVYFTLIGFILGIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D9</accession>
    <name>A0A654E0D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phoH</name>
        <name evidence="4" type="ORF">MARINOS108_12064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="105"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="35238" checksum="028C0CB1975671D5" modified="2020-04-22" version="1">MLEKVITLDNISLVDFLGIQNQNIKEIASAFPESKIISRGNEIRIQGTAPQILKINDILNSLLNHYDKFGKVTHENVVSYINEEQHNSSHAGANDVLVFGTRGFKISPKTKNQKALVEAVDANDLVFAIGPAGTGKTYISVALAVRALKNKEVKKIIITRPAVEAGENLGFLPGDLKEKIDPYLRPIYDALNDMIPSEKLRYYRENGVIEIAPLAYMRGRTLNDAYILLDEAQNTTPMQIKMFLTRMGPESKVIITGDKSQIDLPRNQRSGLIDALDVLKEVKNIGFVELDDRDVVRHKLVKEIVKAYNKQGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G3</accession>
    <name>A0A654E0G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="14985" checksum="0C8CA5A0A918D207" modified="2020-04-22" version="1">MIMLGTCAMAQGTSAENWKTLSKIEYEKSKDEYGEIYVPKFGPDIKSIEGKEIELSGYIIPFEGMFEPDHLIISSVPVASCFFCGGAGPESVAEIYLDESVKYTAKKVTITGKLKLNDSDVDQLMYILEGAKLQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I2</accession>
    <name>A0A654E0I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="32914" checksum="FC0EDFB9DFE51DBB" modified="2020-04-22" version="1">MSNTLEISGLTKHFGKFVAVSDLNLTIEEGQVYGILGPNGSGKTTTLGMILDVVAPTSGHYKWFGGMSPIDARKQIGAILETPCFYPYLTAVQNLRITAHIKQCPDSRIEQVLEQVGLYERKDDRFKNYSLGMKQRLSIAAALLADPPVLILDEPTNGLDPQGIAEIRQLIHHIAAEGKTIIMASHLLDEVQKVCTHFCVLRRGHKLHEGSVDEILGETNEIEVVAEDLEKLEALLAGNTHITKVTRANGQLTLTVTDEIKSADINQYCFEQGITLKKLLTKTRSLEQEFLKILKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P6</accession>
    <name>A0A654E0P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="28439" checksum="41874F7622B267CC" modified="2020-04-22" version="1">MGTQKLIFHDQMGRSVEINFPPRRVISLVPSITELLIDMGVDVVGRTKFCIHPEDKATSIPIVGGTKNFRFEVIDDLKPDLIVGNKEENYKEGITRLSERYPVWMSDITQLNEGLEMIGMLAEVTNMEAEGDLIRTQLVAKLNGLQNSRSGSVLYMIWKKPWMAAGRDTYVHHFLEHLGYRNVVQAARYPELSESDIADLSPDHILLSSEPYPFQEGDREALQAVFPTSSIELVDGEPYSWYGSRLLRVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q1</accession>
    <name>A0A654E0Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17784" checksum="7823DA01222B2DB9" modified="2020-04-22" version="1">MHTVIKSLLFILIPIMLSGCFSKSSGEFPTAEEEKRTIDASEIEGNWVKFYKIDNQVKVFLNNQLVFDSGVGAEKKDEDISFGFTDELRKGKNKLRIELYNDPPYEGFMGFDKHWEIFYELFKEDVPIDYIHEQADDGKTGMVWSMEHDILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W7</accession>
    <name>A0A654E0W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UDP-2,3-diacylglucosamine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_120529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010138">
        <property type="entry name" value="UDP-diacylglucosamine_Hdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990:SF1">
        <property type="entry name" value="PTHR34990:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="9">
        <location>
            <begin position="13"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29510" checksum="05ECF6500642F792" modified="2020-04-22" version="1">MDLQFSDLDPQKKIYFASDFHLGAPDRISSMEREKKIVRWLTEVSSHAAGIFLAGDLFDFWFEYKHVVPKGYLRFLGKLAEIKDKGIPIIIFTGNHDLWMADYLTRELNIPIIHQPQSFQIGPHIVHIGHGDGLGPGDKKFKFFKKIFTNGLAQWAFRWLHPDLGIWLANKWSDHSRDTCSDPPFKGDEEWLIQYCKEIEAKTHHDFYIFGHRHLAIEAPIGTHSTYFNLGEWINGSTYLEMTQDKATLKTFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X3</accession>
    <name>A0A654E0X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="20916" checksum="D14B11ED0F36E05D" modified="2020-04-22" version="1">MYIQSLLRYFLRGLLLVTPVSLTVYIIVEMVKWTDSLLPISIPGLGMITVLFVTAFIGYLANTLFAKPFFDLFNDILKKIPIVSFLYTAINDLVTAFVGDKKKFDTPVLVPFDEHGMLYKPGFITQKDLSEIGLPGMVTVYLPHSYNFSGNVFIVDKSRLMTLEGSNTELMKYIVSGGVSGAIKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E146</accession>
    <name>A0A654E146_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="29393" checksum="8B6EC692849FDEB1" modified="2020-04-22" version="1">MKGKKPIKPKTGGPVKKELGSAPVEIRLNKYIANAGVCSRREADQLIADGKVKVNGEVVTELGRKVLSTDKVVYGGKTLKTEKLQYILLNKPNDYITTVTDTHDRKTVMSLLKGACDERIYPVGRLDRATTGLLLFTNDGDLAKKLTHPSYKIKKIYQVTLDKPITNQDFDDILKGVKLEDGLAVPDEMAVVTDDRMVLGIEIHIGKNRIVRRIFEHKGYKVVKLDRVMFGTLTKKNLTRGKYRHLDPREVVQLKNLSGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E174</accession>
    <name>A0A654E174_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024965257" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="393" mass="44825" checksum="FCABEBBAA065F40B" modified="2020-04-22" version="1">MSKSFFFSAFVLLITHCAAAQDGVKFSDLSWAEALDQSKKSGKLIFLEGYADWSQPCAILEKYTFTDREVGAFFNSNFINIRMDMEDIAGAVLAEEYEVSSFPVLLFLDGNGEVVHRGCGAVETDELMTLGKAALGAGSLSEMEQHFEDGERSLDFLVDYSLMLADACLNRTKLVETFFSELPHSKWMEESAWAMINLNVSDPYSEPFQYLMAYHDMYGLKYGKDTVDQKIHDVMLDQLIAIYEGEDLTLFATQALRQLMSEVDFDKKGELQSLVNLKAADLKANWPVYAENAVKVVQEQQVEDPDQLNEFAWKFYLFVDNEDHLSQAKNWMRGVVDRYPSATYYDSYASLLFKLGEKKEAVKYSEKALQAAEIELEDLMYYKNQLKFFTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I3</accession>
    <name>A0A654E1I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024992739" evidence="1">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="21396" checksum="34EF9E5097AA29F0" modified="2020-04-22" version="1">MKATVQFFALGLLVMLSSCYSETSIGPQGPTGPQGPIGPKGADGQSGFVFEWENINFTAPDYEVILAYPDNFEGFDSDVALVYFLWDTYTNANNEVVEVWRQLDQTLITDDGLLIYNYDHSKYDVRLFLDAEFPLDWLGAIDTDAWIARVVVVPGEFWNSGRVDFSDYAAVEAALGLPNLTQKRAITDRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K3</accession>
    <name>A0A654E1K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="335"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="453"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="725"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="819" mass="92436" checksum="7877C7395B5C03EE" modified="2020-04-22" version="1">MIRNLLTIALRRVKRQRSLTLLHILGLSIGLMSCIFVWLYSNEELSFDQFHEQGDRIYRINQTFIWGDDDALFGSTGPAVMGALWREVPEFESMTRVHTPGNFLISHSNALGEPQVFEEEHLLAVDSNFLEIFTFPLLQGNPKTALINPKSIVLTASMAQKYFGNENALGKQLELGEQPNKQSYLITGVAADVPANSHIQFDFLLSMSSFPRVKKSDDSWMWTTFVTFGLLRADADPGVVAQKVAAVPGKYLEAFLQKYRGISYEEFLASGEEWNLYIQPFLDTHLRSTHVYSRLNEVSDINTLYILWLIAGLILTLSMINFVNLSTAKATTRAKEVGIRKVIGSARKQLIVQFLVESFIYVIGAVIVSLFLVEFLLPAFNGITAKSISITQLFSPDFILVLFVLTLVIGLLSGLYPAFYLSSFRPALVLKGKNMQGLGGTRTRNTLVTAQFAISIAMITCTLIVRDQVEFWKNADLGFDRENKIIIEHAERLGTSVEAYENMLLQHPLVERVSHSSDTPPMIFDFDNFVRNGEEQRNISVNYLTSDEHFLEVYGLSLMMGRNFSREFTETHHIIVNESLTKSFGFDTPEDALNQPITYNEVDYKIIGIVRDFNSNLSDQIYPTAIFDASAPIFRDPSTELTVSLVRDLTADETMDLLSDFESNWNLIQSSAPFDYTFMDQEFLQFFKETIRFSHILKALASLAIFIACLGLIGLVAFVIEKRNKEIGIRKVLGASVTNIWILLSGNFGRLLLIGFVIATPLSWYLMAQWLESFPMRTTISVFTLVASGVLMLLIAVITMSFQTLKASRMNPVDYLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W9</accession>
    <name>A0A654E1W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 2,4-dienoyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.3.1.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fadH</name>
        <name evidence="1" type="ORF">MARINOS108_10030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.34" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="33577" checksum="2F5287F1D23FB595" modified="2020-04-22" version="1">MKYTEGMLREGALKGKTILVTGGGTGLGKSMGTYFSELGANLIITSRKLDVLEETAKEISDQTGNPVLPLACDVREYDQVEKAIADSKAQFGHIDVLLNNAAGNFISPTERLSHRAFDTVVDIVLKGSYNFTLALGKDWIADKHPGNILSIVTTYAWTGSGYVVPSACAKAGVLAMTRSLAVEWAHYGIRANAIAPGPFPTKGAWDRLLPGGLKEKFDPANKVPVGRVGVHQELANLAAYLVSDYSAYVNGEVVTIDGGEWLKGAGEMNQLDQVPEELWDAMEMSRKGGSKIKMMWAYLNGMRKMKFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E211</accession>
    <name>A0A654E211_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">alkH</name>
        <name evidence="8" type="ORF">MARINOS108_20299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="467" mass="51528" checksum="5B1DB0628A3884B4" modified="2020-04-22" version="1">MNPNTGDLNATALFESQKKAALLNRAGHWKDRRRKLHQLEKWILEHRDQIHHAVFKDLAKPASEVDITEVYPVLSECRHAISNLRKWMSPEPINGSLSFLGTSAYVQYEPKGTSLIISPWNYPILLAIGPVVSSIAAGNTVVLKPSEFTPATNRVIREMIESLFPSDQVATLEGDAAVASELLSLPYDHIFFTGSPAVGKVVMTAAAKNLTSVTLELGGKSPTIVDETADIADAARKITWGKWTNAGQTCVAPDYVFVHRSRLEALLAGLRSEAEKRYRDKQNYASIINTRHHERLSGALKDALEQGALLEFGGNVDAGGLYIQPTIVTQVTDQMHLMQEEIFGPILPVMAYDDLDEVIRYINDRPKPLALYHYSGSRANKEKVLKQTSSGSVVINDSVLQFGHPHLPMGGVNNSGLGKSHGKAGFLAFSHGKAVLKQRVGFTVARTVYPPYTSFKKKLIELMLKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E219</accession>
    <name>A0A654E219_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025094970" description="Peptidyl-prolyl cis-trans isomerase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="280" mass="31784" checksum="C1600D2D5FE69718" modified="2020-04-22" version="1">MKKLLLAFVVLAIALSACDKNKDYLITIHTEYGDMKAILYDETPLHKKNFIELAKAGRYDSTIWHRVIEGFMIQGGDVQTKEGIRETEDQRIPAEIVKGFQHTKGAIAAARQGDQVNPKKMSSSSQFYIVDGRKYSEAELTTDQMKLNQGVSQMLRDDQYDSLRQLFTELQLKGDFEGMNQLALDCKDYVSKELGISMDRDVDPETVATYTVTDGAPHLDNEYTIFGRVVEGLEVIDKIAAVKTARGDKPEKDTYLTIELEMVPKKEITKKYGYEYPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E272</accession>
    <name>A0A654E272_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7-keto-8-aminopelargonate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="94"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="635"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="814" mass="92178" checksum="70878E85E0B7F826" modified="2020-04-22" version="1">MISMAKIRHNNYIDTVVEISRNASEKGVVDLYTEDDHFTGRHIKVNGKDLCHFGTTGYLGLEQDIRIKKAAVDAIMRYGTQFPLSKTFISHSAYSELEDKLEKMYGYPVVVTKNSTLGHLGTIPTVVRDEDAIILDQQVHWSVQNSCQIARTRGIPVEMIKHNNMEMLEAKIKDLSSVADKIWYFADGVYSMYGDEAPIGRLKELSAKYPQLCLYYDDVHGMSWVGKNGTGYVISQYGELPQNVIVFTTLSKTFGASGATMVTANKDFYTRVKRFGGPLTFSAQLEPSSVAAAIASADIHLSDEIYDMQKELADKVAYCNACLAKTDLPLIEENNCPVFYIGTGAPAVGYNFVKKLMDAGFYVNMGVFPAVAVKRTGVRFTVSRHNQKEDIKALVEAMDRLYPVALAEETTTKNQVRKTFGLPLLDKGQSAPIKMPASFRVSVYMNTDELPAKEWDDIFKGRNVFDFAGLQFLEQAFGASQAPEHQWDFRFVLIRDKADKIVLATFLTKTLWKDDMLAPASVSMALEKKRLSDPLYHSSQVLAMGSLFTEGDHLYLDQEHPDKDAILNLFFQTLTKIDEELQPDVIALRDFTLSDDFLKAHCDGQGYVKAALPDSCVMEDLSWSTQDDYLQRLSSKSRKHFRQDIEKFTDRVQVEVTNDLDEGELSKAYSLYRNVWDKNFDMNTFAYPQSVFEVMNADSNWEFIKMYPAGGEKSPERLIGVMFSYKNLNLTYVPSLIGLDYDYSDEFSVYRQMLFQTVLRARALDFKRIDFGFSASFEKRKVGAESIQKIAYIQAKDNFAMEMMEVVQNETISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B6</accession>
    <name>A0A654E2B6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SiaC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16789" checksum="CD32A7CFD6084CAA" modified="2020-04-22" version="1">MITHYATNAALAHQFISKRSELTIEPTVNTPFLRYSSAHQLLMIKGSSVKPDMHEFYSNALETFKTELRDSDRLKVYLCFKDLNTSTAKVLFDLFKYLRTRALRGTDVQVVWGAEVTNQEMIETGRDFSEIYELKFRFLTDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C1</accession>
    <name>A0A654E2C1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">kbl</name>
        <name evidence="3" type="ORF">MARINOS108_20016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="43136" checksum="B05BB0F601591BAA" modified="2020-04-22" version="1">MYNALKTKLESELAEIKAAGLYKEERIITTPQDAVIKLQNGQEVINFCANNYLGLSSHPKVIEAAKKTIDTHGFGMSSVRFICGTQDIHKELEEKISAFLGTEDTILYAAAFDANGGVFEPLLGPEDAIISDALNHASIIDGVRLCKAARYRYANNDMADLEAQLIAASEAKVKVIVTDGVFSMDGTIAQLDKICELAEKYDAVVMTDECHSTGFMGKTGRGVHEHRGVMGKVDIITGTLGKALGGASGGFTSGKKEIIELLRQRSRPYLFSNTLAPSIVGASIAVIDMLSETTELRDKLEANTHYFREQMTAAGFDIKPGEHAIVPIMLYDAVLSQEMARKLLEKGIYVIGFYFPVVPKGQARIRVQMSAVHDRTHLDKAVKAFTEVGKELGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C3</accession>
    <name>A0A654E2C3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="48"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="183"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="703" mass="79347" checksum="707C65AB7F5DCA5A" modified="2020-04-22" version="1">MTLKVSGIFSGHILLPQLSVMMKKSFQYQLTLIFLLFGLSLSAQETALNLMPVPEQIEMGEGHFVITKRFSISLTGTYHERLAHEATRFLRRLDQKTALFFDQHKVSGERTNASLTITVERPGEVRLHEDESYQLRVGTESIELNAQTDIGAIRGLETLLQLAGATNGQSTFPVLTINDSPRFHWRGLMMDVARHFMPMDVLYRNLDAMAAVKLNVLHLHLVDDQGFRFPTKAFPELLELSSDGQYYTREDLDDIIAYAHQRGIRVIPEIDVPGHATAILVAFPELGSKDTTYTLERYSGIFDPTLDPTNDAVYDFLDQLFAEVAEVFPDPYFHIGGDENLGRHWNENKDIQAFMKANNLATNHDLQTYFNIRVQKILNKYGKHTMGWDEIMTPEMPKSAIIHSWRGNWEGLVAKQTLYDAARAGYETVLSNGYYLDLMMPASQHYLVDPAPADMDLTPAERSRILGGEMCMWSELVVPETIDSRLWPRAAAVAERLWSPEDVQDVQDMYRRLAIISLQLEQLGLKHISSRNVILRKLAKSKDIEPLKVLVEVVEPMKGYTRNTNGTLYTTFSPFMLWADAATADATVARVFNEDVERYLSGSLEANQLRTQLDLWSKNHKKVLPIINRSPALLEIESLSENFSRLAVIGLEAIGLIESGGKPSSGWVTQCQQVLEEARENGGRTELQVISGIAMLVDELKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D0</accession>
    <name>A0A654E2D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="22759" checksum="06CC26F7E9CC4FFB" modified="2020-04-22" version="1">MLVTKNLKFAYDEAAALNFPDWEVASGDHALILGPSGCGKTTLLHLLSGLLRPTSGSVVIEGTHLEALSSSALDRYRGQHIGFVFQKPHLIGSLTVEENIRLATFFGHKPKRNKEINQVLEDLQIRDLAHRKVYEVSQGQAQRVAIARSVINQPAVIFGDEPTASLDDESCTAVVRLLKSQAEACGATLIIATHDHRVKSEFPNQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N2</accession>
    <name>A0A654E2N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016645">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008471">
        <property type="entry name" value="MnmC-like_methylTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05430">
        <property type="entry name" value="Methyltransf_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_30" evidence="1">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="224" mass="25165" checksum="2BCC85E282492977" modified="2020-04-22" version="1">MTNHKLKLITTEDGSHSLLREDLNETYHSFHGARSESAYVFIEQCLHYYAEQTKKGRIRIFEVGFGTGLNAFLAAAFAEENKVALEFHSVEPFPVVREIFEQLNFGQTPEEQQLLGALHESPWESAQSITSHFSLVKHETTLEGFSAASDFDMIFFDAFAPSKQAEVWELANLKKCFDLLQSGGILTTYCAQGQFKRNLAAAGFEVQTLKGAMGKKEMVRGVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E312</accession>
    <name>A0A654E312_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yghZ</name>
        <name evidence="3" type="ORF">MARINOS108_20642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="39"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="38071" checksum="B005152E269EE2E2" modified="2020-04-22" version="1">MEINDKSGYKRYLAKDDRYQQMKYRRCGRSGVQLPLLSLGLWHNFGHADDLLKGQQILRTAFDLGIIHFDLANNYGPPFGSAETNFGRLYKEDFSAHRDELFISSKAGYDMWPGPFGNFGSRKYLVNSLDQSLKRMNLDYVDLFYHHRPDPDTPLEETMGALDFIVRSGRALYVGISNYPDDQAKKAIAILKDLGTPCLIHQARYSMFDRWVEKGLMNTLDDNGVGCIAFSPLEQGMLTNKYIKGIPADSRAAKGMTYLQRETVEANLAKIKGLHAIAEARGQSLSDMAIAWLLKDERLTSVLVGVSSAEQLMSNVKALDHLGFEADELKKIEDILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E399</accession>
    <name>A0A654E399_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP synthase F1 subcomplex epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="86" mass="9321" checksum="3F68011F2FBBB899" modified="2020-04-22" version="1">MFLEIVTPDEKVFEGEVESATFPGSDGSFQVLSDHAAMISTLGDGDIKFTREVNKKPEETHIAVSGGVVEVLNNKVTVLAEKIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C7</accession>
    <name>A0A654E3C7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraW</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="7" type="ORF">MARINOS108_110118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD15966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="34555" checksum="CE8B5CD3098F4FBA" modified="2020-04-22" version="1">MSTYHTPVLLAQCIDALDIKPDGIYVDVTFGGGGHSREILSRLDTGMLYAFDQDADAKANAEEFRQNRSFTFVESNFRHLKRQLRFYGVKQVDGILADLGVSSHQLDEGQRGFSTRFDGALDMRMDQGAAVTARDIVNDYEQDDLIHILSAYGEIKNARTLAAAIIRARGGKPITRNEELREVALKVAPRGKEMKYLAQLFQAIRIEVNDEMGALREFLEQTAEVIRPGGKLVVMSYHSLEDRPVKNFVNTGNLKGHVEQDFYGNVIRPFTPVTRKPIIPDEEEIERNKRARSAKLRIAVRSEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F5</accession>
    <name>A0A654E3F5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="46567" checksum="1C630A2EA19D1AB8" modified="2020-04-22" version="1">MKLTIKIVLSGFLGCVVLTSADNLYPIDGYELTGIRRLKRLELIMAGELKEGKPISGAQKSISDIKLNLLGAKGDSLEALPATDAKFQKSVNALFPNLDESYSLALLDITPGRPMRYASRKENLQYQPGSVGKIAVATGFFAELSKIYPDSFDQRRALLRDRSVRAGKWAMYDEHTVPIFDLETRKQVKRTVVETDVFSLYEWLDHMLSVSNNGAASVCWREAVLMRVFGKDYPTLTEEQADEYFRTTPKSQLSEIANSVVNDPLRALGITTDEWRLGAFFTKGAGSFIPGKGGSIGTPSGLMKYLVAMERGQVVDSASSLEIKRMLYMTDRRIRYAAAPQLATAAVYFKSGSLYSCKQEEGYQCGKYIGNVNNYMNSVAIVEHTDGTTYLVVLMSNVLKKNSASDHAALASSIDRICKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N2</accession>
    <name>A0A654E3N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">MARINOS108_20184</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="345"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD18382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="49618" checksum="D3959ADE1D5E4417" modified="2020-04-22" version="1">MASKYDLIVIGSGPGGYVAAIRASQLGLKVAVVEKAELGGICLNWGCIPTKALLKSAQVFEYISHAKDYGIDVKDASVDFGGMVKRSREVAGGMSKGIQFLFKKNKIEVINGFGKLQKGKKVEVTDEAGKKTVYEATSIILATGGRSRELPSMPIDNEKIIGYRKAMVMDKQPKKMIVVGSGAIGVEFAYFYKSIGTEVTIVEFMDRVVPVEDEEVSKALERNFKKSGINIMTSSEVTKVDTKGKGCKVTVKTKKGEEILECDVVLSAVGVSTNVEGIGLEETGVKTERGKVVVDDFYKTNVDGVYAIGDIVHGPALAHVASAEGIICVEKIAGENPQPLNYGNIPGCTYCSPEIASVGMTEKQAKDAGYEIKVGKFPFSASGKASAAGHKDGFVKVIFDAKYGEWLGCHMIGANVTEMIAEAVVARKLETTGHEIVKSVHPHPTMSEAIMEAAAAAYDEVIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q6</accession>
    <name>A0A654E3Q6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysN</name>
        <name evidence="8" type="ORF">MARINOS108_20560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="430" mass="48314" checksum="99ECA32CAEB6D7AB" modified="2020-04-22" version="1">MSKTGEQPTAKANSYLDMELLRFTTAGSVDDGKSTLIGRLLFDSKSIFEDQMEQVRQSSERKGLEGADLALLTDGLKDEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTANVALILIDARNGVVDQTCRHSIIASLLQIPHLVVCVNKMDLVDYSQEVYDNIVESFENFASKLEVKDVRFIPISALKGDNVVNRSENMSWFEGSTLLYTLEHMHIGSDHNHIDCRFPVQTVIRPKSDKYHDYRGYAGRIAGGIFKPGDEVTVLPSGFSSKIKSIETFDGPIEEAYAPMSVTITLEDDVDVSRGDMLVRTNNQPEAKQDLEVMLCWLNQKGPMPRTKYTLRHTTADMKAMIKEVRYKLDINTLHRNEEDKNVGMNDICRVQLRTTKPVLADSYRKNRQTGSIILVDDATNETVAAGMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T0</accession>
    <name>A0A654E3T0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="12398" checksum="742A88B4E48F6077" modified="2020-04-22" version="1">MKEEVILFQSISALDSVLKDRKIIQISYNEQKYALTRFGTRVFVFEPKCPHFDYPLVEASVNGACRVVCPWHGYQFDLSTGQELIDRCRPLSVQEATWNADGQLVTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W2</accession>
    <name>A0A654E3W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="52532" checksum="F45AE403C96E8798" modified="2020-04-22" version="1">MQRKLNDEFIKEYSEEFSEKIASDFFQQKEKISGKQILSLTPSKQVNFFVLKILFRKWQEEMKRLESPFFNYKNTEVRKAMVQFMNTLSQHIEMGKEHLVGMLEEAVADTLLIAADPGSYLIMEFDALDVPQVNEKLTKPILKYLRLHKEEVQSFFEENNEVSLDEFLDNAEAHFDELDTAEVVAHELELLSRVVPLSEEELFMDEDSFESHEESEEEIPEMEDDLMEEEPDEEEEVEFYSDEEAYEDEELEREVIEEPEANEEEDEELSFEAAEEEEEASSDEVEATTEVEEEPLDEEEVESDEEVQPEEEEDTKEVAEHSSAAEDWPEETPDEEIAPEESVNEQFPEAGETINDTFSKKSNTLADQLEQKKVQTIMEAISVNHRYMFTKELFDGSREAFTEAIAAIEACESFDDAVELLVQTYAKERAWDMNSEEVKELLKVVFRKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y9</accession>
    <name>A0A654E3Y9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UnbV_ASPIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="511"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120682" checksum="442F67E1E5278D99" modified="2020-04-22" version="1">MISCQQETAREADTLFRKVPAAESGIDFSNVLEFDKDFNIFTYRNFYNGGGVGLGDFNNDGLLDIYFTANQKKNKLYLNEGGMKFRDITMSAGVEGKKAWSTGVSLVDINGDGLLDIYVCNSGDIAGDSKENELFINLGDLTFRESAAEYGLADPGFSTHAAFFDYDKDGDLDMYLLNNSYQAIGSFDLRRNERPKRDPVGGDKLFRNDNGKFLDVSDRAGIYGSIIGFGLGVTVGDIDGDHWQDIYVSNDFFERDYLYLNNQDGTFREVLEDQIRSLSAASMGADLSDINNDSRPDIFVTDMLPEPDERVKTVTTFENWDKYQYNLQNGYYHQFTRNMLQLNNGDNTFSEIGRLAGVEATDWSWGALIFDFQNDGLKDIFIANGIYQDLTDQDFLHYVKQEEVVKKLVSGAGVDYKSLIDLIPSRPIANYAYLNQGNLQFVNKSQEFGLGEPGFSNGSAYGDLDNDGDLDLIVNNVNLPSWVFENQTNKLYPQNNYLRFQLTGLGQNSGAFGTRIEVFLANTTLYLENMPIRGFESTVDSRPLFGLGLAKMADSVKIYWAGGAIQTLINVEANQTLELKEPSEKTGLVSRKTNKEPIFESVADSAFVHRESKWVDFDKDRLVYHMRSTEGPCLCTGDANNDGLEDFYIGGAAGQAGALFIQKASGVFERVPKSYMIQEAEYEDVDCAFFDADGDGFQDLYVASGSSEFSDLSSALGDRLYLNLKGKGFSKQNKIYPNGRYENTSSVVPGDVDGDGDLDLFVGIRMVPGYYGVPASSYLLINDGKGNFQTDLELSAAFQDLGMVTDASWEDMDGDGDQDLIVVGEWMPITYFSNTGGSLVRDSLPNLPDDAGWWNTIEMADFNNDGRPDLAVGNHGNNSRFEASETKPVSMYVNDFDQNGTIEQIVTQYNGEKAYPMVLRHDLIMQLPHLKKKYLEWGDYKNQEMTDVFPPEALAKSKVYEVRELETVVYLSGPNGYTKASLPIEAQFSVTYALEAMDVNMDGNMDLLVGGNLNDTKPEVGRYDANYGLVLLGDGNGGFEALKSADSGLYLNGQTRKIKVVNTKAGPKVIVANNNEAMQIFIAKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z1</accession>
    <name>A0A654E3Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric-dicitrate binding protein FerR, regulates iron transport through sigma-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="122"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="2">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="36814" checksum="20DDC4D236C7EDE9" modified="2020-04-22" version="1">MEKKQPYHPDHEALARYFSEEISAEERRTIEEWRDSSPEHLDSFVTYQTIWADLGTLSGARDLTIDTSMAWQKVKAKKVEHDNHNNVTIQWWWKVAAALVLISSMAFLYQSLFSQTEEITYSAKQIETLRLPDGSDITLNANATLTYPEHMDKSRVLTLEGEAFFEVTHNPKNPFVITTGGATITVLGTSFNVKSMSDRVEVQVETGRVSLASPGQEALLIAGMKGVYLTKDQQISSDTSDPTGQGLFWKTRKLTFEGEALESVIQTLKTAYGITITLENDYLNTCRLNAVFEEEDLHTVLQVISLSLNLEVIETEDGYLIKGAGCDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E424</accession>
    <name>A0A654E424_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="200"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="408"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="563" mass="62384" checksum="9C334768DD721AAE" modified="2020-04-22" version="1">MKSKESEYKELFLIEAKDQIEELDKLFVELEKDQSNQDAIDGIFRITHTLKGNAMGLGLDGVSELSHAMEDVMIAIRNKQITLSKKLFEILFRANDKLTQVVRALETNQKVSYLGIKTSLSIFLKNELDKGAPAAPKEEEIDHQEEETTKQEGQAQVMFSDVIQIPVKKMDDLLNEVGQLIIERDRLIAYSQEIGLATAEFERLKRISSNLQYSIMNARMIQVGFLFNKFHRVVRDAAAIEVKNVALVLKGTEIEIDRNVLKVISDSLVHLVRNAVSHGIEPEAKRVENGKAPEGSITLDARYERDRVIIVVKDDGAGIDHEVIRKKIVQKGMVADAVAKDLTKDEVLRYIFESGFSNSDKVNEISGRGVGMDVVKKAVESIGGQVRIETEVGTGTTVNLHVPSSLALKGTLLFDVGGQEYAMALSYTEAVVTIARSEIYKLSGGLMAKYQDEAISIVFLKDILEMKSLDELGQRGSLQKSFELSTDDDLFNVIIVSYVGQTTGVIVDKVLQQKEIIEKPLAKPINKTKLLSGTTILGSGNVCPVIDIAALTDLIHLKVLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E458</accession>
    <name>A0A654E458_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="84"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="371"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="844" mass="94738" checksum="131B00E2626042E6" modified="2020-04-22" version="1">MLTWLLRADLAEEVLGDLEEKFYSMASHKSLFKAKLNYWYQVLNYLRPFAIKKSKSTSLIRFTMVRHNFTLTFRNFKKHKSQFLINLIGLSTGLACVIFIALWVADERSVDKFHEHDARLYQVMSNHSDASGIRTWKGVPGLLLEEIQSRVPEVSTAVATTDTHEFTLSSGDTYFKSNGKFASTEFLNVYTYALIGGAGISDKSGILITESLAMRIFKSTDVVGRSLEWHFFDQTKDVQVAGILKDIPRNSSDPFDFVMSWDFFHDDLISYKNWFNYYARIAVVLNPSTDPQDASKKIDAILKEQQEEGKVDLFLTRYSDLYLHGKYENGKQAGGRVENMNLFITIALFILFIASINFINLSTAKATHRIKEIGVKKSLGASRWSLMGQYFTESLMLSLLSVVVALVLVWLLLPQFNFLAQKQLTLGMDWLMIQIAGLLIVIVGVIAGSYPALYLSGLRAIEVLKGKLSRKTGEVWGRKSLVVIQFSLSIILIVSVLVVYKQMEFVKQKNLGYDRENLVYFEREGRLINHSDAFINELRNTEGVEDAALSGFVVGGGNSTGGVSWPGKTPQDQIQFWEINSGPGLVEMLGLDLVSGRAFSSEFGADSTSVIFNETAIAAMGMADPLGKTITHYTGDKKIVGVVKDFNLVSLHTKVEPMIFLYNPEKTHYVMARIKPGSEVSTLHKMESLYSSFNPGYVFKPQFVVQDYQAQYASEERVGVLSRYFAGFAVLISCLGLFGLAAFTAERRTKEIGIRKVMGSSVLGIVYLLSLDFTKMVLVAAMIALPVSYFIAADWLQDFAFRVGLEWWFFALAGLSALLVAWFTVALQTIRTARINPVECLRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E465</accession>
    <name>A0A654E465_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="88"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="319" mass="36423" checksum="78E0671C97546058" modified="2020-04-22" version="1">MQLINPNTSERLTLRENHLIDETGKEFELVSGAYRFVEPENYTSNFGFQWNKFGDLQVDTLSGSGITSERFFKATKWTPAQLKGKIVLEAGCGAGRFTSVILNETEAELYSFDYSDSVSANYRMNGPNDRLHLFQASIYEMPFAEDSFDYIFCFGVLQFTPDPISSLQSLIKVLKPGGQLVVDFFPKKGWWTKIHAKYILRPYTSKLSNERLLKAIENNIDWLMKTYRFFSRLGLNRAVNRFLPICDIDNTIPKGLAKEKLRQWVVLDTFNMLSPAFDNPLKMEEVIDTFRKGGLSEIEGEVVPYSGGQNHVSVVRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E484</accession>
    <name>A0A654E484_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroF</name>
        <name evidence="2" type="ORF">MARINOS108_50087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="79"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="36738" checksum="8808B843492830CF" modified="2020-04-22" version="1">MIIHLKGDLAPEKIATLATAHEAIHFRSEDRDILVLSSKITSVPTALAPYVDQSFVMSSDIQLASRDYQPYKRNIKIGQDVLGGSTNHTMMMAGPCSIESWEQISQTAELLKSLNIKTLRAGCFKPRTSPYTFQGMGEEGLKMLVKVRETYDLNIITEVKDSSHVDLVIDHADIVQIGTKAMYDQSILRKCGKSTKPVLLKRGFGTTLQEFVQAAEFILSGGNPNVMLCERGIRTFENKTRFTLDLTGVAYLKEFTNLPVVVDPSHAMGYRYGIPDLTRAAVAMGIDGLLIETHPTPELAKSDAAQQLNFDEFTKMFHSLKPVAEAVGQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B2</accession>
    <name>A0A654E4B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4595" checksum="634754BB1D848104" modified="2020-04-22" version="1">MQGGLPNAIANTLPEGGTISDIAGRHHHILVTSYHHPCHYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I3</accession>
    <name>A0A654E4I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19405" checksum="519846967A87EA22" modified="2020-04-22" version="1">MRTVLFIASLFLLYACTESDTPVPNQTPAEQEVDTTSENGTEDPETADYSIQGDWTTTSEQHTFCQLPENQCSVESYTSINAFWISRMECTSDSVFFYNENAPDNLYGKYSYETLDSVTFAIDLGPNTLIYGIFQINWSDSDHLSLTNEFYNEDSSYFFSDIYFLNRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N5</accession>
    <name>A0A654E4N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="305" mass="34797" checksum="1715ACCA6733805F" modified="2020-04-22" version="1">MVEDYNKIIESLGVRFIKAKNINILKPVTIENNYDIENSLVLVNTGHLRFGKEKEVCGEGEVFFVPGGRQVTVSYGINNPISLSKDDFLNNKELYFQSYIEKAEAADSYSYVSFEAKAFDSVNFFASLDIPPFKIVDSGKIRSLIKGINAEVTSNSPGKGRIVKVMTEQLVVELIRYILKQGLFVEQFATNSTYFKDPRLIDIFTFIKENLGEDLSNKVLANVANVSEDYVGQYFKMLTGINPQDYIEYQRMEEAVNLLRTSKMSIREIGKEVGYKDTAYFCRRFKMMFGIPAGKMRRRESLINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E549</accession>
    <name>A0A654E549_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="150"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="41754" checksum="940CADBD8B9DC69D" modified="2020-04-22" version="1">MNKGKIKLGLIGGGPNSFIGIVHRIAAYMGEQYQLVGGVFDIDHASGIAFAEKLELDTSRAYESLEVFIEKELALPADERIEVVSILTPNFLHHSMAMKLVDAGFNVICEKPITITAAEAVELEQLVERKKVVFCLTHTYTGYPMVRQMKAMIAAGAIGKIQKVDAQYYQGWINPFIHDKDKRAQVWRLDPKKSGQSCCFGDIGVHAFNLIEYTTGLEVEKVLADIDTLYPDNPLDVDGTALIRTKDGVKGVICASQIATGEENNISIMVYGDKGGLKWEQENPTYLTYMQEGKPAQIFKPGNPYNSEFAQESTKIAPGHPEGLFDAMGNIYKGTALAIRGEKVREGAFPGVKDGVRGMKFIEAVLESNKQGQAWIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E588</accession>
    <name>A0A654E588_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032331">
        <property type="entry name" value="DUF4856"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16148">
        <property type="entry name" value="DUF4856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="373" mass="40679" checksum="BE580D1068011EB6" modified="2020-04-22" version="1">MNKLNTILLISGALLAGSLSSCNEGDDDDVSLEIPSTYEFTRDGASTVDYSGQTARLDMLAELKAYIGTANDGAVLSEEVLLDMFANENNPFSSAELNESGKQLKDKTFAADVTFFSSILASAASASASETGASQGKAGLISRGADRQILVDEKGWEYTQLVEKGLMGATFLNQIYNSYLTDAKIGNGVENTELEADKNYTAMEHHWDEAFGYWGVNPEFDVDGENRFLGNYTYGRESYLGSATKLKDAFLKGRTAIVNKTYEIRDEQRDIIYTEFELIVAATAIHYINESIADLSGDDQGSLFHHASEGYGFAMALKYSPYKQITTEELNEVLNAGFGTNGDFWTISVTSLNNAKNILATAYPALTDIADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E595</accession>
    <name>A0A654E595_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_90027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="38552" checksum="2925B77441D75F5A" modified="2020-04-22" version="1">MKGKKTTIHEIAKELNTTASTVSRALNNNPRISEETKKKVFAMAEKLGYEPNTMAASLRKGRSQIIGIIVPYADRIFFSSVIRGIEEEVKKSGYNVIICQSYEKIDNEIDDVNALLSAQVAGIIISLSRETSTYDHLKKVIQKNKTLVLFDRTTDALNTSCVAIDDYQGAYSSVSHLIENGYKKIAFFSGNKKVSIFRERFRGYLAALKDHNLPVVDDYIIEVPSDVEQGKLVTEKLMSLPVKPDAIFSSSDFSALGATKWLLQNNYRIPEDIGIVGFGNDPFTQYLEPTISSVDQKGKEMGKTAAQVFLEQVEGRNSIHRKVLLSPELIIRESSTKRSINKMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A7</accession>
    <name>A0A654E5A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_140089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="489"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="957" mass="107544" checksum="F578DA10740237A6" modified="2020-04-22" version="1">MHEILFGLIMKYFILTALLFGLFFGQAQAQKGFLRGTVFDGETGEPLIGAVVFRQGTTDGTVTDFNGNYSLPLQAGTHTIVYQFVSFRTTTVENLEIVAEKVNTLDVTLQSDVEELAEVVVTAQVIKNSESALLSVQKKSANVLDGISAQTFRKIGDSNLSGAMKRVTGVSVQGGKYVYVRGLGDRYTRTTLNGMSIPGLDPERNDVQIDLFPTNVLENVMVYKTFSPELAGDFAGGTVNVETKSFPEEKTTRLAIGLGYNPKMNLINNFTSYEGSNTDFLGYDDGVRKMPLDPQTEIPRPTSPEPANAGELLESYTRSFNPTMAAKNQSNFLNSSLSFNHGNQLDLPGVKFGYGVVLNYQNQYDYYGNTVVSSYFKDNNKDVNALDAQFVKNGELGRQNVLWSGLVTSAVKFNKHELGLTFLKTQNGIKTATNRVSQDFEETSQTAYENILTYTQRSLTSPTIYGKHNLNKWTLQWSNSVTLARVYDPDFRQVLIAEVPQYQGGEQVGVQYFISGGQGGSAGRFWRDLNETNENFRLDATYALNEKVKLKVGGAGLYKWRTFDTFAYNFSTNQPVENDADWILRPENIWTPDSRQGIYVSGNYEAANNYEARSSVNAAYVMSDAFITPKLRAIFGVRAEQAQMYYTGQDNLGSTVYDDEQTLDQLNLLPSLNMVYSLKENVNLRGSYGRTLARPSFREKSIAQILDPVSGVTFSGNIDLEQTNIDNFDLRWENFFGREEMVSVSAFYKKFNGHIEQTRFELEPREVTWQNIGGSYVYGLELEFRKKLPVEGLMLGSNLSWAQSHVDMTQIIVSRDEINNTVTTEYESRKQQARTDETIDKDRVMAGQAPYLINAFLNYSDFNGINSLSLSYNVQGESLSVVGVGQVPDVYVKPFHSFNLNVTREIGERRNGQIRFTIDNILGDSKEQVWKNHESGDELFSRFDEGRTFTLRYQYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C1</accession>
    <name>A0A654E5C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="7918" checksum="C51FE6D93A808B4F" modified="2020-04-22" version="1">MKSGMIRGILFIAVGLFMIYWAQTHSPRDLGNVVGNAISGSYTMSEPWYYACLGLGILVGVVGVLRTYKSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I0</accession>
    <name>A0A654E5I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13027" checksum="5D85225390998B37" modified="2020-04-22" version="1">MNDMKEEKVQIGEFEELVLLVTAILHEDAYGVRVMDEIGAQTGRKVNISGVHTALDRLEKKGYLSSYMGGATAERGGRSKRYFKVTNLGVQVLEINRRVRNTLYDQIPKVLLETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5U9</accession>
    <name>A0A654E5U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="5211" checksum="448ACA63C97B223C" modified="2020-04-22" version="1">MKIMNKFYGSTLHFGLSGSWGNIFFDHRVQSITQNVSSDFNHITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5V9</accession>
    <name>A0A654E5V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_90034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025060291" evidence="5">
        <location>
            <begin position="19"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="555" mass="60456" checksum="9E7371999264C93C" modified="2020-04-22" version="1">MKKKLFLLALLSANILLAQQNQTSIYENVEFEMPQVNPPVIPDYSVSVSDFGGVGDGLTKNTEAFAKAIDAVVAKGGGHVNVPRGIWLTGPITLRSNLDLHLEDGALLLFTRDKDDYPLVAVSFEGLETYRCLSPINGKDLVNVSITGNGTIDGNGDAWRGVKKSKVTDSHWKQLVKSGGVLSDDGKNWYPSASYKVGADATAGFFNVPETSSVADFEAFKDFLRPVMISIQTSKNVMLDGPTFQNSPAWNIHPLMCENVILRNLNVRNPWYSQNGDGLDLESCKNVLIYNNTFDVGDDAICIKSGKDEDGRKRGIPTENVIIKNNIVYHGHGGFVVGSEMSGGVKNIHVSKCTFMGTDVGLRFKSTRGRGGVVENIFISDIDMINIPTEPIRFNLFYGGQSPVLEEDQEAAVVDEELVPITEETPSFKDIYIKNVTAVGSGTAGYFQGLPEMNLKNINLENVYIEAKNGISMVDADGVTFKDVTVVTEKGYPLTIYNTRNISIFGFEGKTSGVGLVQVLGAKTDKVSLVESDYSDCKTEVVIGKEVDKKAVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6A9</accession>
    <name>A0A654E6A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin-3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yplQ</name>
        <name evidence="7" type="ORF">MARINOS108_60070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD20881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="24242" checksum="3F9CC67E71BC0495" modified="2020-04-22" version="1">MTKSPITYYPHKEEVLNVITHFLGFVLSVAALALLVTFASIYGTVWHIVSFSIFGSTMVVLYLASTLYHSARRKTLRQKLNVFDHSAIYLLIAGTYTPYCLVALNGTIGWVLFGITWGLAVVGILFKIFYTGKYDRLSTIGYVLMGWVAVFAARPLYESLQSEALLYLILGGVSYTIGAIFYSLGKVKYNHAIFHLWVLLGTAFHFVSIFFYLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6F1</accession>
    <name>A0A654E6F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024980586" evidence="5">
        <location>
            <begin position="24"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosidase_C" evidence="6">
        <location>
            <begin position="411"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="494" mass="56724" checksum="BAA48CDD8FF66EBA" modified="2020-04-22" version="1">MKPICHTLLLALFFTACSHPEQATMKKYAENWDSLASYEEAPEWFRNAKFGIYYHWGLLSVPAYANDWHPRNLHVEGTDDYAQHVATYGHPSVFGYHDFVPMFRADSFDAENWADLFVESGARFSGVVAEHHDGWSNWDSRINPWNAKKMGPKRDLVGELERAIHGKGLKFVTTFHMARNLQIYQQDTANWLNDRSYFPYHPNLYTSSTDSVIRMMYGNIPKDQFYENWLGKLQEVIDQYSPDLIYFDGELSKIPDSVKLKFVTYYLNHASMKDKGVVITHKNGELPSEVSLMDLEKGRMDDKTDHFWLTDETIAHGSWSYTETLEVKPAAEIIHVLIDIVSKNGVLMLNISPKANGVIPADQQMVLRDIGEWLKKYGEAIYDTRTWTVYGEGPTVLGTSGHFLEWKTYTAEDVRFTTKENQLYAILMGWPGEDEQVKISSINRKNLKGKTIQEVVLLGSNEKVLWELTEKGFLFTTPSQSMNDPAVVLKLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6Y4</accession>
    <name>A0A654E6Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsU</name>
        <name evidence="6" type="ORF">MARINOS108_20498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7842" checksum="847E298E9A2FBCEC" modified="2020-04-22" version="1">MIVVNVKENESIDKALKRFKKKFEKTGVLRELRERTFFTKPSVKRRHEVIKAEYIQHLRERENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8C3</accession>
    <name>A0A654E8C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024965829" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="27634" checksum="BE63F309546EED78" modified="2020-04-22" version="1">MKTPLLILLLLVSLIGNTQPPAPDYIPADHTSIKIQPILHGTLMLEWNGEVIYADPYGGASRFENLPAPSMILITDIHGDHLNPETLLAIKTEKATFVVPQAVADQLPKEITSKVIVMKNGESRKVNDILITAVPMYNLPESADSRHTKGRGNGYVINLGGKNIYLSGDTEDITEMRALKDIDVAFVCMNLPYTMDIDQAASAVLEFKPAVVYPFHYRGQAGLNDVEGFKKLVSEGSDQIEVRLRNWYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E909</accession>
    <name>A0A654E909_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16583" checksum="7A563B8CC8BE2656" modified="2020-04-22" version="1">MYTYATTLLLMRENKKLAIAVAFHDLDIWVSDGMDYLSGSEQLARDYLKNSDFDYLPDEVAFFIKNHHKLWPIKGNIEAEAFRKADLIDLTSGFIRYNIPESIISETERTFPRENFTRMISSRALNHAIRHPLRPFPMIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E970</accession>
    <name>A0A654E970_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twitching motility protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="143" mass="16362" checksum="270B600908738EEC" modified="2020-04-22" version="1">MTSMKGKVFIDTNVLIYLFSTDEPEKRIHCNKLLSSLEKDHVMVWSTQVVQEFYNTLTRKLGVSPLKLKSYFSYFGSFELVVNNMTTINTAIDIQINNQLTFWDSLIVSAAHQANCSTLLSEDLTHSQKIDTLTIQNPFELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9N7</accession>
    <name>A0A654E9N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="434" mass="50638" checksum="E30EA563029C534E" modified="2020-04-22" version="1">MAKINIFWHRRDLRGHDNTGLQYALTAGLPVLPVFIFDTNILDELEDRKDPRITFIHDQVTRLNTYYREHGSALDVYHGTPDKAFEAILENYEVNGVFTNRDYEPYATARDSALENSLKSKGVDFFTFKDQVIFEAGEILTKEGEPYKVFTPYKNKWFEKFNQVGVSKHDSEANLKTLVPMRGREIPSLSQMNFKRTEIDLPPAEISDALISQYAARRDFPAEHGTSKLGVHLRFGTVSIRDLVRRAHGLSDTWLSELIWREFYMMILAHYPRVIDQAFKPQYDRIPWINDETQFKKWCNGMTGYPLVDAGMRELNATGYMHNRVRMVVASFLTKHLLIDWRWGERYFASRLLDFELSSNNGGWQWAAGTGTDAQPYFRVFNPYSQQEKFDPKLKYVRRWVPEYGSPDYPEPIVSHKEARLRAIETYKLALSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA10</accession>
    <name>A0A654EA10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6238" checksum="FE606B7B92B87033" modified="2020-04-22" version="1">MVFALLNKKTVWDNPQQHRIWPGYSIDLITPDSTQQTPLKAGFFMVIGLLALADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED38</accession>
    <name>A0A654ED38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cysC</name>
        <name evidence="3" type="ORF">MARINOS108_20557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="22010" checksum="C267FA21BD9E147A" modified="2020-04-22" version="1">MSIQENIIPHDHAIKLEDRVRKNGYAPKLIWFTGLSGSGKSTLASAFEVYLFNQGYGTYILDGDNVRSGLNKDLDFSDSSRVENIRRIAEVSKLFVDAGVVVLTAFISPFRADRAQARDLVGGENFIEVFVDTPIEVCEQRDVKGLYAKARAGKIPNFTGIDSPFETPEHPDVHIRTAGQSVEESLKELIEQIVPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEN5</accession>
    <name>A0A654EEN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025008645" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="15511" checksum="B1E721DA3E0B7BBC" modified="2020-04-22" version="1">MKNLYQWSILCLIAALLAGCAKNITTSRTSEVFEEFYDRFHADERFQLDRVKFPLSGEYEGPEGSQPWVKSAWEPHKQKVTEISDPQYITDIVKTEGEVIEKVQEDGGGFYSERRFQLIDGKWYLVFYDTVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF28</accession>
    <name>A0A654EF28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_60073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024849283" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M43" evidence="3">
        <location>
            <begin position="193"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="4">
        <location>
            <begin position="1298"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1366" mass="148902" checksum="E0566EF99584F36A" modified="2020-04-22" version="1">MNYRLTLVMLCLGFMATAQSLTPQRSKPTQPKGPFFQTLTPKSPITVPEHRTCFTTEMEQKLQAKYPQRQTTTSFEEALQKRLSQASSARSTDEVYRIPTIVHVVHNGESVGTSSNISAAQVNSQFEVLNEDFRRLGAGANTHESGADVFVEFVPVLTDPDGQTLTEPGINRINGGRVFWEETPLEGTLKPETIWDPERYFNIWVVNFGGDLDGVLGYAQFPSLSGLDDLPDDMGPASTDGVVIGYPFFGKTGNVLEPYDLGRTTTHEVGHWLGLRHIWGDGGCEVDDFCEDTPNAGGPNFGCSANDSCTEDAFPDMIENYMDYSDDACMNIFTIDQKARMRTVLEFGARRSTLIGPLCDEAEVAQVGTNTTTPPMWYTFTTTEESIVTVSSIGQTTQNTYLTLYPGCDMPAINTSDDVLGTTQSELSTLVAAGETVKILWSARNSEEEFNWTLSTTAPTEGAACGLALLAIEGNNQVASTDLNTLWYSFTLANTESKIIIDGGDKSYKTYAGNCQQLQLITEGSGSQTLLDVAQGDEIFIAFEPGGGDFSWSLAVEDLEAGEACSVAVDAIEGTNTTPSTPYWFTYTMTEFANLTISSTGQTEVATYAKLFDGCSGNLISDNQPSGDQTEITVALSEGTEVKILWDNSSASFDWTLETNPFEPGENCFAAITAQEGINTAPQAPVWFTFTMPMEGNLHITSADLTDEDTDLYVFEECEGSLLFSNDDIDYDNDIYQSEGIIYGLEEGATVKIFWADSWGTESFDWKLTVLESQPGDACGNAKEAVLGSNTVPEIVGDLFWTYYTIPESDKKLVISSTSSETVYVASDCEELLLFASGYEGAIAPGLVAGQEILIVWSIEGGGDFSWTLAMEALDQGDDCSDPLTAEEGTNAAGYAPAWYTFTMPMAGNLLISSEGMTTEDTDLLVLSACDGDVLGASDDIDFNNGILQSEVYLQGLSQGESVYIYWTPQWSSAAFSWQLTVSEPLPGEECEAPATAQVGTNTVPELRVPFYWMTFTMPEANQKLVITSTSEEYVYTVVDCDLQIISSGYENLTIYDLAKDEEVLIAWELYFGGGFDFQLSVEDIEPGDLCGDPIEAQVGSNSMDHAATWYSYTMPKAGDLRISSVGQTDADTYLFIFDACEGDIIAQVDDTEDNLQSEVLLQELAAGETVLIYWADLYSTEGFSWKLELEGITNAAPVIANQSFEVLGPVANGHQIGTVVATDQDGDDLKYTITAGNDDAAFALHESNGTLTLADVDLWDQNDTQLTIEVTDQIEKASAKITVRFLVLGWSAQDFRIFPNPTSDLLTIEGASYTIGYLTDLSGKVVKTFKGNTSTVSLQDLRDGIYLLKLEKDGDYQVTKVLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSG8</accession>
    <name>A0A654DSG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022442">
        <property type="entry name" value="B-helix_rpt-cont_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03805">
        <property type="entry name" value="beta_helix_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="65"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="45319" checksum="66D6268D3F227AEE" modified="2020-04-22" version="1">MKTTYLIFALAMALISCDNPSVLELGEKWQSIERDLQTQLITAGDSAVIELPEGHFMFTKSLLVDGNKYLTIKGQGIDKTILSFEMQEEGAEGLKIANGVSIIIENFTIENAKGDNIKVTDTRGITIRNVKSQWTGTPEESNGAYAFYPVLSSNVLVENCIAIGASDAGIYVGQSDSVIIRNNEAYYNVAGIESENSRWVEIYGNHAHDNTGGVLVFDLPGLTQYGHTTRVFSNNIYENNFRNFAPKGNVVATVPPGTGVMLLATRNIEIFDNLIADNRTIGTAIASYDLVEAMATAEESQLNENIEKSKKDVGYDPYPNEVYIHNNVYKNSFWFPTWKNDFGLLFTMKFPFVTPDIAWDGISPDGSDFALCVEQEDVKFANLDAANDFENLTTDLGRFSCVGNFVDPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSG9</accession>
    <name>A0A654DSG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">30S ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="13731" checksum="3E7D3A96DF3E86E6" modified="2020-04-22" version="1">MSFIFENLKIWQKALELSQNVNALTKCFPVEERFALTSQMKRAADSVSLNIAEGSTGQTKKEFKRFLAISLRSCVEVVGCIYLARARQLITTDQFDALYQELLILTKMIQSFRKSLNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSV8</accession>
    <name>A0A654DSV8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ORF">MARINOS108_10155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="305" mass="35539" checksum="FF486161A7F54D48" modified="2020-04-22" version="1">MNLKKNILVSVVGPTAVGKTALAIEIAKYFNTQIVSADSRQFYREMNIGTAKPDKEELAQVKHHFINSHSIKSHYSVGMYEKEALVLLDELFQRHDVVVLVGGSGLFFKAIWDGFDEMPAVDLDLRASLNRWFEEEGLEPMLKELKEKDPEYFGLVDQQNHQRVIRALEVIRSSGETFTSFRKGKAVSNRNFVNLKFGLNMDREILFDRINKRMDLMIDAGLFEEAKALFPYKDHNALQTVGYTEIFNYLDGKYDREEAVRLLKRNSRRYAKRQLTWFRKDEEIKWYQPNESERIIRLIADSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU63</accession>
    <name>A0A654DU63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15614" checksum="3CBED9ED5B613A81" modified="2020-04-22" version="1">MPDIEIFAGMTGVKSFIIAIIILANMGSALVTPLVYLDFEMRRDYISRVLCVERKQPITVCGGSCYLAAQLDKAQEHQEKSKQLTPKSFTFFFSETRHIEWEVDQLALAQDLTFSHLSEDFPKSRLAFDIFHPPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU79</accession>
    <name>A0A654DU79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="entry name" value="PTHR38165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="413"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="506"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="721" mass="78561" checksum="B0038940E2C2E67E" modified="2020-04-22" version="1">MKTKIYPSHWILKFFVATTVMLLWSLTTWAQTLPYLVENNSEYPDNQVFVAIVGITDGHVWVDPATGQVHPMSQSDNTVQGPVNGGNQGPGGDGKYANCFRRLSEIPNHTINIPKIAGCRIMISFESQLFLYFFGHSGNPSGYAAPNLANPTDPNQGIKFELVELTFNDYGLWCNTSRVDSYQYPMGLEVWGNGFYKKVGEKKTHAQIISQWQSTAPSEFQSLLNASEGTIHFPTKTSTFPTNFFQSYIDAIWSKYSSQQLVFNSGQAGVWRGSVQGNQFIFTRDGDGQVATIPGKPTTIEAMEGSGVMASGAQWDLVVQAQFVAAITRHAIDLNVGSGVLQDFGNTSSYYQTWPYNWYAKFWHQTDISVDGQTYAFAYDDVFDQSATIHTPSPTNIKITVGGFYGTTGGGGGVATLYQHCDYGGYSASLNVGSYTLGQLQALGVANDDISSLQLQSGYQITMYQHDNFGGNVLVKTSSDNCLVNEAFNDDISSVVVAQVSSGWSTTIEAENTAVQSGTQTEACSEGGLNVGWIDANDWMVWDVNIPSNGPYTVEYRVSSPNSNGMIQLEKAGGSPMYGTRSVPNTGGWQNWTSVSHTVSLTAGQQQIAIKALAGGWNINWLKITSAGGSRTAAEVDIKTAVSTEKLIVYPNPVQDLLSLKVPGNEIIQAAVIHDLSGKQMIQWAEYEETSPLDVSQLKAGHYLLSIKTSTGSYTTRIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU81</accession>
    <name>A0A654DU81_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012368">
        <property type="entry name" value="OxRdtase_Mopterin-bd_su_IorB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036389">
        <property type="entry name" value="IOR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="210"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="735" mass="80620" checksum="B8DF696688B38C8B" modified="2020-04-22" version="1">MTLITTQFNRRSFLKVSAAAGGGMVLGFSWLSGCMPKSETALAIPEEWFDINGFIKIGDTGLVTIFSPNPEIGQNVKTSMPMIVAEELDVDWKNVVVEQAKLNTDLYQGQIAGGSQSIRRGWEPLRMAGATARRMLMEAAANEWKVDVNELTTEKGVITHKSSGKSTTYGAVAGAAVSIPVPEEVTLKNTADFKLVGSRVRNVDAKKIITGQPLFGLDYHREGMLIAMIVHPPAFGMKLKSLDDKAARAMPGIRDVFTINTAPQERQWSDTNAFPELIAVVGTSTWEVMKAKKAIVAEWEQETPLENTEDHQDQLARALENTTEADVRRIDGQPDQAFAKAAKVIERTFTAPFLAHNTMEPMNFFADVTENTAELVGPVQTPEYMEKSISSLLGMPLENIDVKMTRMGGGFGRRLYGHFGLEAAVISQKIKSPVKLVYTREDDISQGTYRPAYRMTFKAGLNANNELIAYEVKGVGIDSNPIFANRFPAGTVENYRAVGTAVSSNISTGAWRAPNSNFTAGAEQAFLDEVAEAAGQDPIDFRLKLFERAINAPIGEKNDYEPARYAGVLKLVKEKANWGAEMPGVSRGVAAYFCHNSYVAQVIDLIKVEDQIKIKKVWCAVDCGIVVNLEGALNQIEGGIIDGIGHAMYSELSFVNGAPEQSNFHNYRLIRHTEAPLEIETFFVQNDISPTGLGEPSLPPAIGALANAMYRATKQRYYHQPFSTAAQQERAVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUC9</accession>
    <name>A0A654DUC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="307" mass="35327" checksum="F97D506A25C341E1" modified="2020-04-22" version="1">MRKYLIERFPTHDERSLFTLVENRTAYSYETCELNLFETHEQAENVHLTFDHFVLTSMLSGKKVMTLPQRASFEYLPGESVILPPGEMMNIDFPEARKLNPTQCIALTISDEVIKKTIDMLNEYHPKASSWGDWQIDPTIFHLTNNLELADTVNRIVRITKSEQGKAKDMMVELTLREMVIRLMQTQARVIFESSYSVLSASHPLAAAIRFIKSNLRNKIDLSRLANQACMSRASFFKKFKETMGVSPAQYILKERIKLACHHLSTSDMSITEVCFACGFENLSHFVTTFKSEEGMTPGSWRLHEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ9</accession>
    <name>A0A654DUJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4694" checksum="96DF0ACBCC3C7FE0" modified="2020-04-22" version="1">MNFKNTTMSKSQDAKKSVKKEPAKTPKEKKAEKREKKAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM6</accession>
    <name>A0A654DUM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1531"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1490"/>
            <end position="1524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1750" mass="199189" checksum="FB7950C9D0A4173F" modified="2020-04-22" version="1">MKILERASKIAEGFNSSIYQLSDDTYGREVILKVMKEDFNYHPHSSQLYNEDKYLRGVSTRGVRGSIDLIEDSQSPILVLEYFDGISLKSWVNEKPRTFIDCLKVAIQICEALHEVHSQYNLIHRDISAHNILINDQMMTNIIDFGLAINVDTKLNIKGMSDQLLGTLPYISPEQTGRVNHAVDYRSDLYSLGVVLYELFTGQLPFNAADPLELIHAHLAITPQPLSSINHEIPTVFSDIILKLLSKDVEKRYQSARGLLEDLKKCMNQAALRVEIQHFELAQNDESGRFLIPSKIYGREEQISQLLSAVENIGSGQKEVTLVSGKSGTGKTSLLYEIHKPITGKKGYFIKGKHQQFQKDRPYQAISQAISSFISLILSENEQRLAHWRGRLQEALKDQGKLITDFIPNLELIVGKQDNLPILGINEAQNRFNYVFTQFIKVLATKEHPLVLFIDDLQWADNASLKLIRNLIIDNELTHFYFIGAYRDNEIDSKHPFNVVFSELPKQGVTIQQIHLEDLSFTDTQSMIMDTFSCNERKARELTHIVQTKTAGNPFFVNQFLKSIYEKGLITYQHGTTAGTGSWEWDIEQLESTNYTENVVDFMVDKLRKMNPGTQQQLTLGACIGDRFHLKTLSYIQEPGTRDLMSDLWQAVIEQLLFVEESHGDVAHIAQLKNPEADTMLTYRFAHDRIRQAAYELIPDKEKAKVHQRIGELLLHNIDLEKHSDQVFEVVNQLNRGIGKADDGYRIRLCELNYMAGSKAKASSAYESAIDYFEAALRTLEDSDWMTNHSLLQALHLTTMETYYILGKYDQMKSIGDLLLRKATSKMEYLQPHNVFIQSYIARSKHLDLITYGLSILKEVGIKLPSRPSDTDILVGLVQTKLKLIGKKTGYFESLPDMEDEHMALAINMMTSISTASYHNFPKLFPIVILKSIRLSIQYGNSIDSIPFYGGYGTILCGVLRDYSTGYEFGQLSLRLLQKSSRYKAVVPKTLVIFYGFINHWKDPLRTALDPYEEAYLAAMEIGDNQYAASAAFLKACTGFLSGLRLDELVPEIEHSLERMPSLKQESYHQYMKIVYQGIHNLSSGSELPWELEGSVFSQRAFESDDYKKELREDDTALFHISFYQLYLNFLFGRYEEAFQGMISTKKYLEVVLSTAYIPLVNFYDSLVRLKLYATASSSQRKKHLGQVKANQKKMKRWSEHSPTNYLHKYLLVEAETLSVIRADQSVKGAYDQCIKAAETNEYLNELALCYELAGRHHGQSGNEELQSYYMGKALKTYRKWGARAKANQLKDEFPYLEERKDRSIHTSFSGGSFSYGSLSGNNLLDLASVLKAATTISSEIKLSRAIPTLLDILTENAGAQSGAFVFLNNDVLELYARSSVNEEAKMVPAREISEVSDLPVSVIQYVRRTQDTVLLDHAEKDERFHQDQYLQTHSIASILCMPVIHQQALLGIIYLENRLTKGSFTAERTDLLSLLSGQIAITLHNALLYDQLEQRVEERTREIEKQKNKLNHQNLQLTELNEEKDFLISVVSHDLRNPLHLIKGYTNLALKNKDPKEAEEFLGYVIESSNRMEGFISRILNVSAINSREINLNYSEVDMVNLLNEEVKAFEAMAKEKDINYSFQSDEAQLPTAIDPGYFNQIISNLITNAIKYTQPGGQIQVRLELIAGGDYYRISVEDNGQGISTRDQKLLFSKFQTLSAKPTGGEESTGLGLAIVKKYVEAMDGRIWCKSEYEEGSQFFVEFPIDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS2</accession>
    <name>A0A654DUS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="2">
        <location>
            <begin position="70"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="1">
        <location>
            <begin position="310"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="53515" checksum="863E7CD6ED449AEA" modified="2020-04-22" version="1">MKSYSDLIEQTFYFPTKEFRVENNLLWFHDVNLMEIIKEYGTPLKLSYLPKISENIQFAKKIFTDAIQKNSYDGTYRYCYCTKSSHFQFVLEEALKNDIHIETSSAYDIPIVRNLNKSGLLSKDRMIVCNGFKRPLYLQYISDLINDGFTNTIPVLDNLNELAHYHQNIKGDFKVGIRIAADEEPNFAFYTSRLGIRYHDIVPHYKEMIAGSKAKLKMLHFFINTGIKDSAYYWSELSRFIYKYCELKKICPDLDTVDIGGGFPIKNSLGFEFDYAYMADQIVANIKWICQKNHVPVPNIVTEFGSFTVGESGATLYSILDQKLQNDKELWYMMDGSFITHMPDVWGLNEKFIMLPINHWDNPHHRVNIGGLTCDSQDYYDSEAHIGEVFLPRIDDEETLHFGFFHTGAYQESLGGYGGIQHCLIPAPKHVIIRKDANGQVSSELFAPEQESESMMKILGYTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ8</accession>
    <name>A0A654DUZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="21159" checksum="FDF2D04CFFA52E8B" modified="2020-04-22" version="1">MQDPDQVLVERLRNKDKRAFELVFNEYYGLLKSYAMRFMDDPDDAEEVIQEVFVKFWEKCDTLAPDSSIKSYLYRSVHNTCLNFIKHQKVKDSYRQYVITFMEEAVEGPSPDGENSNVQERIFEAIDNLPPRCSEIFKLSRFEGLKYQEIADHLSISIKTVEVQMGKALKTLREKLKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV17</accession>
    <name>A0A654DV17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_10504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="23880" checksum="14F0312A1B358B0E" modified="2020-04-22" version="1">MKEDTFTNKWLNRAFILSLITIFYNLVEGGIATFFGSQDETLALFGFGVDSFVEVLSGIGIAHMVVRMKKTPIESRDHFEVTALKITGTAFYLLVLGLIIGAGLSIYYQSNPETTLVGMIISIISILTMYILYKQKLKAGKELSSEPIISDANCTRTCFYLSFILLGSSTLYELFKIPYVDAIGSLGIAWYAFKEGKEAFEKAKTKQLSCTDNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV99</accession>
    <name>A0A654DV99_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="254"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="44704" checksum="74BBDE484D693FF0" modified="2020-04-22" version="1">MFTTSEIELDQAALANNLSYIRKIIGNDVRLSSVVKGNAYGHGIFEFVPMAETLGVDHFSVFSADEALEVTNISMQRSQVMIMGFVDNAELEWAVLNEVEFFVFELDRLEMAIEAARKVGKKARIHLEFETGLNRTGFNKTDLVRAVEFLKKNLDHFELMGDCTHYAGAESIANYVRVKNQIKKFNKMDKWLRSTGLEPLVKHTACSAAAISYPKSRMEMVRIGILQYGFWPSKETFIDCIKHVSSREDPLRRVMKWKSKVMDVKEVNTGEFIGYGTTFMASENMKIATVPVGYSHGYARSLSNQGRVLIRGKRLAVVGIVNMNLLIVDVSECPGAEKGDEVVLIGDQGDNSISVSSFGELSDQLNYELLTRLPRNIPRTVITHKTLTNQIPTNGLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVB8</accession>
    <name>A0A654DVB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="4669" checksum="0B10F98421203E3F" modified="2020-04-22" version="1">MGHYQMAFLVDPGTVELGHYLSGFKGAGGVAWTLKTIRQSICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVG3</accession>
    <name>A0A654DVG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17435" checksum="F7145D4EE201E083" modified="2020-04-22" version="1">MDTTDFKILDLLQQDGRLTHKQIAAELNLTITPVYERVKRLERDGYIKHYVAILDPDKLNKSLVAFTSISLKEHSKTYIKKFELEITKIAAVVECYHIAGQFDYLLKIVIEDMKAYQAVVIDQLASMENIANVNSSFVMTEVQKSTAIPLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ7</accession>
    <name>A0A654DVQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type_ISP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Type_ISP_C" evidence="1">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21554" checksum="2DA31ED35D435543" modified="2020-04-22" version="1">MKASWGYSSEIDWLDPGDPMRATIRQQLGGLLHGHVPHENLHAQRDSALGNLVARQLDLIYTPEPSSHEVCFAESAEVRPEFRSTFHSNHLIEYCYAMVFSSVFRKRFKDFPNEGFLIPAPPDASFFWRMIRIGNELRLLHLQENIDTSLEHQGSVMGSKELSIDVELLDAMERTKTLRREIDVICEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW75</accession>
    <name>A0A654DW75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Quinol:cytochrome c oxidoreductase pentaheme cytochrome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024834648" evidence="7">
        <location>
            <begin position="27"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="429" mass="47185" checksum="C0FB971B25202173" modified="2020-04-22" version="1">MSKATRFVLISLTYTFFLLLSFGALAQDAAGGGDADGIPTDEALASAGASIFKANCTQCHAINEVVIGPALKDVHERRSKEWLTSWIKNSQKLIQSGDEYAVEIWQQYNKTAMPAYPFSDEEITSLLSYIKVESNKEPAPVATAESGSTGQVVAGQGDSVSSGYLTAILVVLVVVLVLILIVLGLMVSVLTKYLKDQKELDAEDVEVVNQKTDIQKVLTSDFVIGSVIFIFVALLLKTAIDGAFTIGVQQGYQPNQPIAFSHQIHAGQFEIDCNYCHTGVRKSKAANIPSANICMNCHTAIKTESPEIQKIYAAIDYDPSTGEYGENTKPIEWVRVHNLPDLAYFNHSQHVEVGGLECQTCHGPVEEMDVVYQYSTLTMGWCINCHRETEVNTKDNEYYTKLVELHAEHSKEPLKVEDIGGLECSKCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE2</accession>
    <name>A0A654DWE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="34185" checksum="B2E25ABDE4580B3A" modified="2020-04-22" version="1">MQGRLLIYVLGLLIMMGANAQKITVKGGFIEDSLKIGEDIHYWVSAEYPDHLELIFPDTTYNFSPFEFSGKEYFPSIIKTDRAFDSAVYTLQSYEIDPIQSLSIPVFILKPTGDSTRIDAGLDSIFFKQLLEVVTDTTSLKTNLAYQNVPTQFNFPLLWIILGVLMVLTLATYLIFGKKIRKTIRLRKLKKDFIAFSEHLTMDIRSLKEAPNQKIAEHALTEWKNFLERLEQRPFSKLTTKEIMALEYTGELNGTLKNIDRCVYGGRSSDELYKDFQAIEDFTQHRYSVITDQIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL7</accession>
    <name>A0A654DWL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized transporter YutK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yutK</name>
        <name evidence="10" type="ORF">MARINOS108_11056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="9">
        <location>
            <begin position="93"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="204"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="428" mass="45467" checksum="AAE5981AE2E73EA7" modified="2020-04-22" version="1">MDVLRAAFGLIFLVGVAYLFSLKRKSVDWRLVLTGIALQVIFGLLITQIDFVRQAFNWISRQFVVLLSFSGDGASFLFGSLMDTENMGFIFALQVLPTVIFFSTVTSGLYYLGVLQWIVKGIAWIMTRTMKLSGAESLSAAANIFLGQTEAPLLVRPFVPKMTNSELMCLMTGGMATIAGGVLAGYVAFLGGGDPVAQERFAAYLLSASIMNAPAAIVMSKIMLPELNRDQINTDLTVSSDTMGVNLVDALARGAAEGLKLALNIGAMLLAFIALIAAINYILMALGDVTGLNAVIVSSTNGSFDGFSLEYILGQFFRIFAFVIGVDWNESLQVGSLLGQKVVVNEFVAYLGLSEFVAEGALNEKSIVIATYALCGFANFSSIAIQIGGIGGMAPTQQGNISKLGLRALFAATLATMMTASIAGALMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM5</accession>
    <name>A0A654DWM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoacetone oxidase family FAD-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="44997" checksum="E485E81424C2F6F9" modified="2020-04-22" version="1">MSHSHKKKVIIVGGGAAGFFTAINIAEKHPHYEVLVLEKTNKLLSKVKVSGGGRCNVTNARQQPSELTPFYPRGGKKLYTVFKEFSTADMVRWLGDRGVKTHTEADLRMFPTSNSSQTIIDCFTGEAARLGVKVIQNCGVKHIEATEHQWSLVTSQGPMIADKLIIATGSAPSVWGFLSQLGLDLVPPVPSLFTFNIKDLRISGLMGTSFSEVNIRITGTKLEEAGPMLITHWGLSGPAVLKLSAWGARELAEKNYHFHILVNYLGKESNAEVGQWFDQQKQDHPKRKVLNYPPGELTRRFWEQLCKYCEIAEEDNFGEITKKQVNKLTEELTQGLYEVKGKSTFKEEFVTSGGVALSEVDLKTFEARNFPNLYLAGEVLDIDALTGGFNFQACWSAGWVISEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP4</accession>
    <name>A0A654DWP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="6406" checksum="B4CC5B0657100251" modified="2020-04-22" version="1">MDLYPSGKLIKNIFNIFGEWFLTIPFFYALPGQILRSGQEFDTQGGPGVRGTAALAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT9</accession>
    <name>A0A654DWT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024920971" evidence="4">
        <location>
            <begin position="23"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="918"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="845"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1286" mass="142972" checksum="166EC4F1FFDB68D4" modified="2020-04-22" version="1">MMRFQWCKQLVYILSIALFASAFEGHTQDIDLKFTHLNTDEGLSTGTVNCVFKDSKGFIWIGTVDGLNRYNAYSIKIFKTDPDDPTSIGGNIVSTIAEDHLGRIWVGTRTGGISIFDWETETFSHYRNTADPHSLSNNYVRKILIDDQKNVLVATTSGLNIYNWEDDTFDRLLHDPADKSTVSHDAVFSIVQDAPGSYWVGTHSGGVDYFDLKTRSFKHYNYVENYDMGLTNRKPLMKDSSGNIWIGTDGEGAYRYNPGKDSFTHFEYSANKNELKSNIVTCFYEDDLGRIFIGTDGAGINIYDPLKNTFSYVQRSLFDEESISSDAIYDFYKDDMGILWVSTFRGGVNVYSKYHSKFKLYVEVPGESNSLSFNSVIALHEGRDGAIWIGTDGGGLDRLDQETGEFRHFKHSPTNRNTISSNVIKSIYEDRLGYLWAGTYAAGLNKYNPRTGRVVRYMPDADNPRSLGDRNVWAITEDYENNLWIGMLGAGLSRYNRERDDFEHFRHDPNDPQSIGGNLIVVFHEDKNRQFWIGTEEGGLSLFDKENGTFRNFGHDPESTDGLLNNNVRALHEDRLGQLWIGTASGMNLMDIRTKVLTVAPVNALLPNPVVNGILEDDQGNLWISTNKGLSVYDPKENTIQNFSKSDGLQGNEFNYSSSVRSRKTGKMYFGGLQGLNAFDPQEIKLSPFDPKIVITDLKVFDQSISQKDTLNGRQIINKSLAEISEVSFTHRENVITIEFAALDYTSPLQNKYRYMLEGFDESWVEVGATKRSATYTNLDQGDYVFHVNGTNSDGVWSSSPRTLKITILPPWWATWWFRLLAVVVVISGGVYAYKWRVGQIKAGQRELQRRIDEATAQVKQQNEALREQQESLQGAIEDTNFVIGEAVESGDFSVRIDVESKSGEWKALGASINHLFESILVPFNTINRIVNALADSDLSMRYTDDAKGDVLQLKDSFNNALDNLSDLLHEIIEQVDTIGTSSQEMFVASEQMNLSTGEIASSIGEMSSGAQNQVSRIDEASKLIEGILAFSNNVSQQADTINQGALRGVEKSDTGKKLIEKVDHSMKDIIATSKDTNESINILSNRSGEISRVLNIIKDVAHQTNLLALNAAIEAAKAGDAGKGFAVVAEEIRKLAEDSGKSAKEIEVMVVEIQGAIGGTAKLIGEMSASIKGGEEASRDASASFDELATSYAQTLSMSEEIVKATSQQSDHLKKVVGLMESVVVIAEETAAGTEEVASSSSQLSAGMSEYTQRTQEVSEIVEVLKSKVKRFHLSQQEPMEESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU2</accession>
    <name>A0A654DWU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homospermidine synthase (Spermidine-specific)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="36693" checksum="60EA5279ACE48B7E" modified="2020-04-22" version="1">MSDKPITSFIEKHFLHFNSAALHDAAKGYKHHLESGKKMLISLAGAMSTGELGISLSEMIRQDKVQIISCTGANLEEDVMNLVAHSHYKRIPHYRDLTPEQERELLDQGLNRVTDTCIPEEEAFRRIQEHIVKIWKDAEAKGERYFPHEFMYKLLDSGMLDEYHEIDPKNSWMIAAKDKNLPMVVPGWEDSTMGNIFASYCVKGELNPRTMKSGIEYMTYLADWYLENAGTEGIGFFQIGGGIAGDFPICVVPMLYQDLEKTDVPFWSYFCQISDSTTSYGSYSGAVPNEKITWGKLDIDTPKFIVESDATIVAPLIFGYVLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV2</accession>
    <name>A0A654DWV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="382" mass="42814" checksum="D9277AD094A7781A" modified="2020-04-22" version="1">MKHLLTLILLASLATQCSSPTPQEGSLLDQNSELAVTQYKGMQKQLGEGEFPRSYENGSFTTSSSEWWCSGFYPGTLLYLYEETEDSSLLQEANRMLTLLEKEQYNTSTHDLGFMMYCSFGNANRLNPQAAYTNILINSARSLATRFSPVTGCIRSWDSKPEDFIVIIDNMMNLELLFWATKATGDSSFYNIAVTHANTTLENHFRSDNSSYHVLNYDSTGAVKQKKTAQGLHDESAWARGQAWGLYGYTATYRETKDEKYLEQAVKIAGFILSHPNLPEDKIPLWDFDAEKDALRDASAAAIMASALIELDTYAPDKGYLKVAEEILTNLTSDYTAEPGTNGQFIITHCVGHLPANSEVDVPLTYADYYFMEALMRLEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW2</accession>
    <name>A0A654DWW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="52"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="50805" checksum="81F8D1A8D5C89CE5" modified="2020-04-22" version="1">MLRILFLLITISCFPACKDDGLDKPPTTNPEDTVELSDTLIIPPLQEMVVYEVNMRAFSDAGTFSGIQSRLDNIQDMGANVIWLMPIYPIGEVKTVNSPYCIRDYRAVNAEYGSLNTLKALVSAAHDRGMAVIIDWVANHTAWDHPWISAHKDWYSQDGNGDIIEPPGTGWTDVAELNYESGSMRQEMIESMLFWIDEAGIDGFRCDAIDFVPDSFWNEALASLKAHTDKDLILLGEGGVLANFEVGFEMNYAWDFKTAIARVFSEGMSAETIISTHKSEYTKVLAGGEKLRYITNHDLYAWETTPIEDFGLKGSVSAFVITSYLGGIPLIYDGQEIGHPTNISFFDKNPINWSLNPDVYDAYKDIMTARAELSAVHYGEMKSYTSKDVVAFKRFTAKQEVLVIVNVRNSLKVFDVPDELANTQWKDVLADTDKTISSSVSLEGLQYLILVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX98</accession>
    <name>A0A654DX98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18120" checksum="A53978AD2E771B2D" modified="2020-04-22" version="1">MNALSNTVSVQLLEFQEQYASDFARLNYEWLETYFTVEPHDREMLDAPNEYIIQSGGRIFFAKVEDEIVGTVALIVETPDTFELAKMGVTPKYKGLKIGKMLMQHAISEARKAGMERLVLESNTKLTAALNLYINSGFKVAPLNECSPYARCNIRMELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC1</accession>
    <name>A0A654DXC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_11306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="10">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="9">
        <location>
            <begin position="282"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="426"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="ACOX" evidence="8">
        <location>
            <begin position="625"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="769" mass="87362" checksum="984BC47448AAA46F" modified="2020-04-22" version="1">MIQSDYLKENPFLFSFVPMFYMVWADAILTPSEILKIRELIEQQAWITQKERTFLLSHLDPQNPPSPGQLKEWLFEIRRVSQDLTPQMKRSLVDIGIELARLNARNQDDKTLEAARAPLTDIEEALGILSREAAFHLRSQERTTQTGGQQTEASFDLNKMSELLDGKNRVVIRKVKTILSDPEFEYYRGESTAEYREQVLKWCQYLADQGFGGMAYPEAFGGQDDMASYFAIMETLSYHDLSMVIKFGVQFGLWGMSVYFLGTEKHHQQYLKDIGTLKLPGCFAMTETGHGSNVKGIETTATYHHKTKTLVINTPHHGAGKEYIGNAAVHGQMATVFAKLIIDEVDYGVNAFVVPLRDSDGHTVSGVIIEDCGHKMGLNGVDNGRIWFDEVVIPVENMLDKFASIDADGKFKSPITSDNRRFFTMLGTLVGGRIGIPRSGLSAMKTGLTIAIRYGDTRRQFGPENGSEVPILNYRTHQRRLMPLLAESYAIHFSLQYLTNRFLSRSEEDMQEIEAMAAGLKSFATWRTTHALQECREACGGKGYLSENRIDRLKNDTDVYTTFEGDNTVLMQLVAKSRLSEFKKEFSDINLFGVLSYVASQAKTSLSEMNPLTVRNTDPEHLLDFEFYLNAFRYRERDILTSAARRIKKHLDNGMDSFDAFNQTQYHMVNVGFAYIERLILEQFIAQVKKTEDEGCKMILTKLCQLFALSQMEKNKGWYLEHDYMAGVKTKAIRKMINQLCLEVRENAVPLVNTFEIPESCLAAPIAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF7</accession>
    <name>A0A654DXF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="257"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="38629" checksum="4C4BB17F2B4DFF02" modified="2020-04-22" version="1">MKTRVKIERIIQETREAFTLVLENAPSIAQYLPGQFLNFFLQINGQEVVRQYSFSSSSFIGEPPSVTIKKVAGGLASNFIGEQLRAGDEVSVSPPNGRFTTTFGVARRVLMVAGGSGITPLYAMMKSILAQEPESRVTLLYANRSSESIIFKKELDHLERKYTGRLEVRHFLSAEDAGLEKQENTFFRKLNRFDFQKYVDAYWKETPEVFICGPEALMNLSVESLTILGLSADQIKMEAFSGMPGIENRDDKPEAYTQVEIKDLNGEPITFKAESNQSVLKSALDAGIRLPHSCKESMCGACKVRLVSGQLNMKTNYALPDDEVERGYVLLCSGFPQSEKLVLQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR3</accession>
    <name>A0A654DXR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="18290" checksum="022B729849A0DF35" modified="2020-04-22" version="1">MNSKIYKIGFFILLIINIGLVVLFVLGPKPPRPESGIKNEISRELGFTDEQQAAFEQMAMNHREAIRKLDQQERQLLGSFFNQLSQPQPNEPNEELLQEIMQLEKDKIMITYNHFEELKDLCSEEQRIRFDRVIQRILPALTNSSERPMKPQRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU3</accession>
    <name>A0A654DXU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="26222" checksum="8D15004EBCE4AC26" modified="2020-04-22" version="1">MDCLSCTNAQCIIKKNAHFDKMHGYMEKKSTLVCKKGQNFIIEGAPVHGLYFIREGKVKVAKTGLNGKEQIVRFTRNGETIGHRGFGAGQFYQISAVALQKTTLCNFSTETMKGMLMEVPTLTYDLMTFYAEELNRSEAKVKKFAQMTVREKVIDALLYVERKFGRTKGIINVQLSRKEISDFAGTTEEQVIRTLSGLRKDGLIETPGKGICIKDVELLRKEISEHNYFIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY2</accession>
    <name>A0A654DXY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="372" mass="42733" checksum="AE199F51757DE126" modified="2020-04-22" version="1">MTPRKNTCLLVMLLQSLWAQGQLTLTNLSKMKYLTVVALIGISAFSLLAQQPDPPGQVEVGEQPVNEAYLFAHMTHEDYGRLYYSVSLDGLHWYRLNDGNCVFEDYKGHPDITKGHDGRYYIAGNRSDASPEINIWVSENLIDWKTHSVYIPELKKTPGYSQALQRIGAPKLYYDEASGEYVMTWHTPHQEGTKEDPERYWASQRTLYVTSKDLKTFSAYPERLLPWDMGTIDVFIRKAEGKYWTIIKDERYPTLDWVTGKTIRIANSESPLGPYDNLSDPISPNFREAPMLIPSPNGAVWYLYYEQYPGVSYGLSIADSLSGPWYQASGYTFFADWDKYSLPEKVRHGCMITISRLEYNQLVDEFGIEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC4</accession>
    <name>A0A654DYC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_12062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4131" evidence="8">
        <location>
            <begin position="39"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="234"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD14680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="710" mass="80861" checksum="4D63C4CE6C232744" modified="2020-04-22" version="1">MFKWTAFPFIRISFFLSLGIILYDSYGVLWSGLPWRQMSMIFLLALIIPFWLGRPILKGVVYLLLMVYLGGLIAMLADESAVPGHYSSFEKVEGFMGVVISDNTERDHYHRYEVAVHMVAQSDSLNAAHGKIFLYVKKTQEDSTHLQYGDVVAVDKNFFPIEGPKNPHEFDYRAYLKKQKIYAHAFADPSEVREIGHEPPNPLLAHAMGIRTYARQKIEDWIPQQRERAILTALILGVKDYLDEETTSAYAAAGAMHVLAVSGLHVGIVVMILSVIFQKWKETRWGNVVFTIGSVAIIWLYALITGFTPSVMRASTMFTVIIVSSAFNQRANIYNSLGLAAFVLILYNPYVIYAVGFQLSFAAVIGIVILQPRLYRLLDFSGIVTDYVWSITCVSIAAQVATFPLALVYFHQFPTYFLVSNLIVIPAAFLMLGGGISMLLVGSILPALGQALGFVLQGFSWVVNELILGIKWLPYPIFDWLYFDAWDTIFTYLIMSFLVLAIWKYSYHYMVLAWLAAITLATWLHFKSFEQENQKRMVFYEIDGITAIDLINGREAVLLIDDFSEANKELIAFQINPNRLASGLPKVEDTWQLMSSSEWVQVHSCFDLIQWDGVRVILMKHMETYQLTHPLEADVIYFKDAEMLSYEGLLPGIALLGTNFNYYETRDAKRIFENRKIEARSLSQDGFLELDLNQTRPFSQRKHRLATISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG8</accession>
    <name>A0A654DYG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="5" type="ORF">MARINOS108_12089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="4">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="25418" checksum="41016CAD76DC47EE" modified="2020-04-22" version="1">MESDSRLLELNDRYGNLTYLDRLKMLFGEFEPEEILVTTSFGSTSIALIHMISKVAPRHPVHLINTGYLFKETIQYRDQLINEFDLNVVDVQPRERSHEFTSNHKVWEGNPDFCCFINKVEPLNALKKGKKVWVSGLLGFQNENRAGKRIFEESQGLLKFHPIIDMSQEDLNLYRTIYELPAHPLLYKGFGSIGCVQCTKKGVGRAGRWEGKEKTECGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK2</accession>
    <name>A0A654DYK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-ketoglutaric semialdehyde dehydrogenase 2</fullName>
            <ecNumber evidence="3">1.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.26" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047533">
        <property type="term" value="F:2,5-dioxovalerate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="526" mass="55815" checksum="E0A03558E673B266" modified="2020-04-22" version="1">MILTGQNFIGSERTGMGRNTFRAVNPATGDLLPISFYEATEAEVGSAVLKAEAAFQEYKEQSSEDRALFLEAIGDELWALGDELIERCMSETALPAARLNGERMRTINQLKMFASLVREGSWVDARIDTAIPDRQPLPRPDIRQMLVPLGPVGIFGASNFPLAFSVAGGDTASALAAGCPVVVKAHPLHPGTSEMVAQAIVSAANKTGMPDGVFSLVQGTSVEVGMAIVLHPRITAVGFTGSFRGGKALFDAANQRNTPIPVFAEMGSSNPIFLLPGAVSARGEGLASGLVGSLNMGVGQFCTNPGLVIASESTETSQLLEAMGDLVSKTASGTMLSEGIKDNYEAGVNRLTSFPGVEIVSEGISGQGKNQVPSKIFKTKATDFLGQSGLEEEVFGPSTLSVIAEGKDQMLEVARKMQGHLTATIHGTDADLEEYKDLIHILERKVGRLLFNGYPTGVEVGQAMVHGGPYPATTAPQSTSVGTGAIKRFVRPVCYQDFPQASLPLALRDHNPLNIWRLINGELKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM8</accession>
    <name>A0A654DYM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gliding motility-associated-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025667">
        <property type="entry name" value="SprB_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13573">
        <property type="entry name" value="SprB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024868196" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="732"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="1845"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1999" mass="212653" checksum="56160B9AA1CA5899" modified="2020-04-22" version="1">MKNLLTATIVFLLFSSSAVAQNWNIGLTAVNETCFGANDGEIELVLTGSGVSGYSFTWEVFESADLVTPYASGTVDNPFGTNVIDGLFQDDWTVTVTRSTANTPKTRTSSITVGGSASLLSVTKTVLDQNLCNGDASGSVQISATGGTAPYEYGLGIGAGATSPSYSGGYTDNGGLFESLAAATYVAFVRDANGCVKANTSGDFQITQPTAISIDFDTVNADCNNQNGQIIINSISGGTPYSAGAGFPLNFEIEWQNADDASVIATNVSAITALDSGSYQVIVTDKNGCTGSTQMDIYKGFNFVVNDQQDVTCTSDNDGSIQVRLDTDSEDDETPFELRIYDGDMTEITLMRQTGVGVGTADFTGLGPDTYTIRAFGQTGCTLDVEATLAEPEAPQLVSATQTPVICKTDATGAITFVVTGGSGSYSYSVDGGANYFTTPTIGNLTAGVYDLWIRDSNGCPVDVADKEVTEPIKQWGMSFVSTSNITCAGAGDGEYTWEFDAGLDTDPIVEPENIVWVDVNSTDTVATGVFSKTDLEEGEYRIDVTANSGCYRSLTFDISEPAVLAISGVSPEFLCPADLSPDPTEINVTVTGGTTPYTFEWKRDGGALGGESVTDLATSSKIEDVTNDHVYSFHVTDAEGCTTSKSFDVTIPDPISIQLVSETDIACKNETTGAIDITVTGGTQTSGGSYFFNWAKNGSAGYANTEDISNLGPGTYQVTIIDDNGCEKIDPNTYTITEPATTYSLSGTITDVVCNGANDGKIVALYTPESGHPNVASVSWTKDGAAYPAGDGMTTITGLAPGTYVMTTVDNTYACSKSISFDVLEYPVLSVNPTVTQNECFGDANGVIDISPSGGLELGTFMVRWTRNGVAQAAYNDLLSVSNLDDATYKVTVTDDLGCAKSSTIVMASPDELIATAEIVNVACKGESTGSIDVTITGGVAAGGTYDLVWTKDGSSFAPITEDLSNLAAGVYQLTITDDNGCVSDPFDFTVTQPSTTYSISGVSTPVTCNGANDGTIDITVNLGSPTHPNPTDITWTKDGVFFVSNTLDLKQGNLEPGTYELTTVDTYGCSRSLSFDIVEYPELVMNPTITQNECFGDATGSIEIDPSGGYLGSNVSYSIRWYKDGTAVPSKNNQTSYTDLADGVYRVVLSDYAGCSLDSTITLEAPEPVSATANIQEIKCRGDETGYIALDITGGTSPYVITWKENDASGASFSSADSIFDLAPGSYFVAIEDQNDCDPFTATYVITQPATDFNISLDPTQIKCTGEKNAAISLVIDAGAGHPDSYSLTWYKNGDVLSSQTGVGESGIVPIQNLGPATYSVLVTDANGCERSDEYTITNPTKIYFRPEISNVTCNGYSDGSITLDPTGGYGNYTVSWKSEAAGTLSDTDFDLGDIPAGKYTATLTDSEGCKLDTIIFMDDPLPIVVASTIKNTSCVGGADGAVTITPSNGTPPYSYQWLLDGKLISTEQNLTNLEAATYQLIITDQFQCQYNSSDFTVADPPSEFFIEGTITRVTCHDDFNGEIDVEVEITGEPDLDYSVYWEKNGVLFSQNTEDLNGIGAGTYEIFIEDEYGCIKSKTFSLENPDELAFVFDIVDVSCFGGNDGSVSAQVSGGYGTYQFSWQKDGLPFSSTSSFATNLEAAFYKVTVTDLEGCALTRTVEVAQPDPFRIAVTSVSNTCATPYDSEIDATVTGGIMPYSLQWLKDGLPYSKVEDLTGIPAGVYQLLAVDSNFCETSSVEVTITSPERLGVDVITQKNNLCPNTENGAITFQGTGGSFPYTYSFDSGAYASKNNFVNLAGRKYLVSVLDDVGCTFDTLLTIDTDYELEAEFSLETEEFAIDFPITLTDESLGQGIEKWFWDFGDTRADENQNTTVTYTTPGVYVLKLTVENEVGCTLSKTDTLDIVRGYNFAVPTAFTPNGDGSNENFRPGFQNVKAMSMRVQDRNGLLVFESDELSASWDGKFNGHPVPQGPYYYEINYTAKSGVTRKHTGKIFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN6</accession>
    <name>A0A654DYN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-l-methionine hydroxide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="28830" checksum="64B8BFB9123343FD" modified="2020-04-22" version="1">MALVTFMSDFGTEDHYVAAVKAVAHKMGPETHIIDISHEIYPSDIGHASYVLKSVFRDFPTGTVHLCAIDMNSREPSKLVAVQLEEHYFVGYDSGLFSLLSDQPPTAMVELSTNDLNGSTFLAKDLLAPAAVALANGKKISELGRPLDVLKTLYARQLKVTKREIAGNIIRVDHYGNLITNIVHSAFETIMKLNGEKPYEVCFGRERSRKIHSAYHEVESGEYFILFNSNQQLQIGINKGNASELLGLHLDAPVIINFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS8</accession>
    <name>A0A654DYS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="22801" checksum="69E73FB2B3BB482F" modified="2020-04-22" version="1">MQAQRHGMVSKRIKRNFRVVKYVIYKETLVDWHEHMWSFVGSFVGIGLIAWAQGVHFAGEDGVFLIGSFGASGVLIYGAIQSPLAQPRNLIGGHVLSACIGVAISQVFGSNISLGAPLAVALSIICMQITKTMHPPGGATALIAVIGSERILDLGWLYVVFPVFSGTMILFVVALVFNNVTPKRSYPTNSRFTRVFKKTILMQFKSNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX0</accession>
    <name>A0A654DYX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="102" mass="12167" checksum="EF8E0B14E9749538" modified="2020-04-22" version="1">MKIYQLIWSYECKPETAAEFEKEYAQNGAWFKFFEPCDDFLGQDLAKNIETGHYILTDKWISRASYEGHIAENKAEYDRLCEQFKALYEKETLIGRFETVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ49</accession>
    <name>A0A654DZ49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD</name>
        <name evidence="5" type="ORF">MARINOS108_12001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="23921" checksum="900AEA23145CC3C0" modified="2020-04-22" version="1">MLKAEGLYKAYGKLPVLKGIDLHIREGEIVSIVGASGAGKSTLLHLLGTLDSPEKGKIFISNTDVFQLNQQKLAGFRNKHIGFIFQFHNLLPEFSALENVMIPGLIAKRSGTEVKRRAMELLGLLGLLERKDHKPGELSGGEQQRVSVARALINDPSIVFADEPSGNLDSKNADELHQLFFDLRKELNQTFVIVTHNKELAEMADRKLEIEDGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ89</accession>
    <name>A0A654DZ89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="32080" checksum="93AFAFA516FEB189" modified="2020-04-22" version="1">METNSKVWFVTGSGNGLGRNIVGTALKSGHQVVATARKVEQLSDLKSLYGDQILVKTLDVTDEGQAKEVVSKGIKHFGRIDVLVNNAGYGDNRPFEQMPAADFRKLVETCFFGVVTLTREVLPYMRKQRSGHIIQISSGGGRMAVAGQAAYHASKWAIGGFTEGLAQETAPFNVKVTALEPGGMRTNWGKRAYADTIELLPEYEPTVGNTIKFLENYWGNENSDPQKVAEIILKVSEADEVPSHILVGSDSYNLVKEASAKRWEEAEKWKDLSFYADFENEMVLPELMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ91</accession>
    <name>A0A654DZ91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="26625" checksum="6C8919ADED357683" modified="2020-04-22" version="1">MKKALITGANKGIGFGTARLLLQNGFYVYIGSRNVQNGVNAVEKLKAEGLDNVEVIQMDVTDESSVQKAREHIGKRTDVLDVLINNAGINGGNSPYTALEAKSDEFQAAFDTNVIGTARVTNALIDLLRKSDEPRIVNLSTSVGSLTLQSDPNWQAYDYAKYAVYAASKAALNMYTIHLAYELRDTKFKVNAVCPGLTATDFTFGHGGDVETAAKRVVKYATIGEDGPTGKFFSEETNPETGIVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZA1</accession>
    <name>A0A654DZA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="76" mass="8919" checksum="BD5BE09B62B1C85C" modified="2020-04-22" version="1">MSQLKEFVQVFQRELIDDKIDENTDYKNHSSWSSLVSLIIITEVEKSFGVLIEVEHLRNNTTLSDLYEQCMPLTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH8</accession>
    <name>A0A654DZH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="9289" checksum="10634504E04609D5" modified="2020-04-22" version="1">MSPEINTPTYPYEATDRFDHSRYRLSQATYYQIMDLIKFYHESMYLLPDDEVVIVERLIDQNHTEYCKVSVNHLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ8</accession>
    <name>A0A654DZJ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6443 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045619">
        <property type="entry name" value="DUF6443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20041">
        <property type="entry name" value="DUF6443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024840342" description="DUF6443 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6443" evidence="3">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1390" mass="152801" checksum="D829AE4844AAA27D" modified="2020-04-22" version="1">MYKYITSLFILTLFFSSVLKAQTYDDYHQEYSLSTFLNTVPAGYTGGLTIDISDNYLTVSIVAQPASTPKALSVKQGQIVLINSVPAVTLKGLGAFGDYFVDIDASGYLTIDTEVMGTIAKVFSINETYGLELGFSAYPVFTSTENYVATSTMINAVTTSNVKSNDRMIGVTYFDGLGRPVQTSSLFASNDGYDLITPITYDAKGRQDTEYMPYPDNLFGAYSNARVADQLSYYGSPSEGVQSTGAPFAKTIFEDSPLDRPRKQGSPGAPWQPTTNPDDLSDHSRKMSYRSNVAADNVRKYLWSDIAGEMDDAGFYGDNTLFVSVIYDEDNHLVHQFTDRKGQVILKRVFDGASGLDTYYIFDNRGNLRRVLPPMASAGLLSPTPPATTYTNFSATWNYTSFVQNSGSGGGAVDVAITNNILTMDFSAGFSSNTLKSGNTVHLNTKRIPDMTLGTICDGKYTVKVTNNYIVIDHTPGGSVTGFDASFSVDIAELSRQYVYNEDLAVNSYDGRSYEIVKGSVTLLPGFNFTATTDETFSVGLSDGTSAGALNYLYGFEYNYDQRNRLIGKKVPGADWVHMVYDKRDRLILTQDGNQRLSNQWTFTKYDHLNRPVLSGVTTISGGRQSVQDAVDTFYQGSAPLYESRGSTIHGYTNSSYPVDSDPFHYYSVTYYDDYAFGIPSGYEYAKPADFNITKTDRVKGQVTATKTKVLGVTAYHWSLNYYDAKYRVIQSVSANYVGGQDRITTQYKHIGWVEKTRRVHTGGESVTIDDRFAYDSQGRLLKQYQTINSDPEVLLAQNRYNDLGQVIEKNIGQEGTGAPAQSVDYRYNTRGWLTTVNGGTTFDDANDRFGMELKYDGAPTGYKQYNGNIGQMLWKTTGGGQNANSQNYKFGYDDLSRLTAATYNSSSKTNYYNVSGISYDLNGNIQTLVRKFNNSNADNLDYDYYGNQLTSVGDTSDNSLFDEEFSEGNQPNEYLYDQSGNMISDANKAISNISYNYLNLPEQVVVPEGTIYYTYNAQGVKLRKFFDKTSGIDETTDYVGGIQYKNGALDFIQHGEGRAVKNGAGFDYKYNLTDHLGNVRVTVDAAGVVIQRDDYYPFGLTFNSFKDGSDNKYLYNQGTGEKTFATERQPELGLDMTKFRMYDYALGRFTSIDPKAEQAGQESWTPYHFGFNNPILQNDPYGDCPVCVNYFISSASALYVKYSGIVSNVRAPVQRSINGTSGVPSHVNMDDRSRFVTNTASTWSDANQVATNAKKLGVEVTKDWGEALDKTGDAISNAGLASTPVTGPVGLSVMKVGDAISATGKVTKAVANAVDGDYEQAGVELTKAGISAVSGSLVGNMVDASKLVGNAAKNDIVQETILQTVNKVGNTASNAVIDEQVKKQEDERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL7</accession>
    <name>A0A654DZL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="69" mass="7046" checksum="25A135F255EA87F1" modified="2020-04-22" version="1">MVAEGVVVAEVCTGAEASVAEATLVEAAALAGSPVVVEVSVAVVLLVGGNIKTEQWLRNILLQNQKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM0</accession>
    <name>A0A654DZM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025071702" description="DUF1080 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="59"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="30494" checksum="D58B9EA585781757" modified="2020-04-22" version="1">MKTLFSIFFITLSATLVAQDIPQPNWDELNKTKPWEITELYKDVPTVTPRANSGAPSDAIVLFNGKDQSQWQKAQFGSPVKMDGFKAMIPLIDPDYKGAPAEWTIIGDALEVAPGTGAIATKKAFGDVQLHLEWRAPKMPADKTGQAGGNSGVIFMGMYEVQVLNGYENPTYSNGQVASVYKQHIPLVNASTQPGEWQTYDIIFMAPKFSEKGGVVSPAKVTVLHNGILVQNNVELLGPTCFIGTPYYIAHPEKLPLVLQDHSDRMQFRNIWVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN8</accession>
    <name>A0A654DZN8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="36306" checksum="D8BAC2381C30CB98" modified="2020-04-22" version="1">MDVDNGGTPLTIPNTDGTGRPNYIDTDSEDDNIPDFEEGFYEAGPTNYQTSYINRVTAYNAANAATSNTLYPTGDTSPADGTPDYLNDSDGDGIPNLLDPQSAYFLDDDGDGLINLFDPNQNGDFYGNVNGVPDRDDDGTPNILDGSDVPLPLDFIAFSGTVQNENVNLKWTTANEVNVSHFDVLHSTGGSKDFKVIGSVQAVNIKELVNNYQFTHQNAPDGYNFYRIREVDLDGYEGFTEIINVVMEASNISWTIYPNPTQDHLSIRSTVIIPDSRVMILDVTGRTIYDQHVSFESKEAVLDLSKLGAGVYHVIIELPDSKKSFRVMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY7</accession>
    <name>A0A654DZY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="165" mass="18427" checksum="004E1EF88483D581" modified="2020-04-22" version="1">MIVLAVLGTACVSGGFDENPQLDELENALKKAPKVESISVNGVVVEKNTQSQRQVDARIGDVLKLDAAFSSGKDAQLTELEFFRQYYGVIYPQEAPHPVDSLTDGFYDLSGLESSFSYEYTVPEEDDEGFHFEAGNIITIQYRVKNSLDNYGYRSLVIRLVDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E018</accession>
    <name>A0A654E018_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetylglucosamine-6-O-sulfatase</fullName>
            <ecNumber evidence="6">3.1.6.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="423"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="548" mass="63530" checksum="92AB8596DC73D355" modified="2020-04-22" version="1">MMMKIRFLQVAIGVLVLYACSPQKEEVQSPKRPNILFIMSDDHAYQAISAYGSELIETPNIDRLANEGMRFSNATVTNSICAPSRATILTGKHTHINGKIDNLMPFDTTQVTFPQIFQANGYQTAMFGKLHFGNNPKGVDDFMILPGQGYYLNPDFNTPSGDTTIMGYVTDVITDLTLTWLKEKRDEEKPFMMMYMHKAPHRPWWPRPDKFAEFTKKQFPEPESLFDDYKNRGTAAKTAEMNLLTHMMYSHDSKIRPELVEKMGDKASPKVEEFENGFYGPYGRATEEQKALYDPILDSINSWFEQNWPSLTDEEKMKWKYQRYMQDYLGCISSVDDNVGRVLDYLDESGLAENTIVVYTSDQGFYLGEHGWFDKRFIYDESFKTPLMVRWPGTVKAGTVETEMVQNLDFAQTLLSAAGITPPSDMQGESLMPLLVGDKEKWDRDAVYYHYYEYPSVHMVKRHYGIVTEEYKLAHFYFDVDEWELYDRLNDSKEMNNVIDDPAYAEVVDELKAKLTELRVKYKDSPELDSLFIEKYRSLQVEKGNDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E064</accession>
    <name>A0A654E064_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="28509" checksum="C02FEF458AD53C15" modified="2020-04-22" version="1">MNKQEILTGGYLAAYITGELSADEEQEIETHIASDQQVRREYFDLQKTLELVAFHHSIAPSPVVKKFVMQNESVIKNIHSPGESSGGSRYLMAASITVALISALSAFYFWNQWKDTDSRLALLTARNIEMAESYQRVNQELTGIRGDLAVLVSPEFSRIILNGTDNATDAKAVIYWNPTEEEVYLNSANLAQLPQNQQYQLWALIDGVPVDAGVFDASDGTFQIMKNIARADAFAVTIEQSGGSESPTLSTMQVYGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E067</accession>
    <name>A0A654E067_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gapA</name>
        <name evidence="10" type="ORF">MARINOS108_11994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="PTHR10836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="35780" checksum="B63AC90562B00F0C" modified="2020-04-22" version="1">MSKVKIGINGFGRIGRLVFRVAAENPNIEVVGINDLIDVDYMAYMLKYDSTHGQFKGDVEVKDGKLVVNGSAIRVTSERNPADLKWSDVGAEYIVESTGLFLTKESAKGHIDAGAKKVIMSAPSKDDTPMFVMGVNQDAYTSDMVFVSNASCTTNCLAPIAKVLNDKFGIESGLMTTVHATTATQKTVDGPSMKDWRGGRGAGQNIIPSSTGAAKAVGKVIPELNGKLTGMSFRVPTPDVSCVDLTVNLKTETTYEEVCAAMKAAAEGPLKGILGYTEDAVVSNDFLGDSRTSIFDAGAGIQLTPKFLKVVSWYDNEWGYSTKVVELLEYIASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E082</accession>
    <name>A0A654E082_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="24235" checksum="17842F66058EA7E3" modified="2020-04-22" version="1">MANNLDRLFRENIDQFEVTPQASSWEQVQGQIAGKKGFWVTPMKIAAAIVVLLAATIVVINLSEKEQQGDYLSAIDHPEYQDRYSFRLELPSVNLENTVAPVVATQPKIKAQKASQTITEKADFEEITYEAISVASLKNFQLEAELPVRNQLKIPGLPKQETPAVKITYIATHQPQTDSLKVNKFNTLIAYFSNDVSPTEILADIREVKDNLFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E093</accession>
    <name>A0A654E093_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arc family DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="54" mass="6333" checksum="CE845417AEB94A85" modified="2020-04-22" version="1">MAKKKPFVLRIDEETFKAIEKWAADEFRSTNGQLEWMIHKALKDAGRLKKEDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E096</accession>
    <name>A0A654E096_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="286" mass="31771" checksum="334D1067BD6FB03E" modified="2020-04-22" version="1">MRLAMTKVTKHFAKASTQYLKVNGIDFAYRRFGNSKNKVPLVGFQHFTGTLDNWDPLIMDALAAEREVIVFDNVGVGNSGGNTPNTVESMTADAVLFIKALGLSKIDVLGFSLGGFIAQHLGIYYSDLIRRIIMVGTAPQGAEVLTGFAQLIEHAMSLDPEERFLKIFFTDSESSREAGRSVLQRLNARKHDRDVETSVDSIMAQMKAISAWATPPVEDHLSQIDHPVFIVQGSDDEMMDSNNSYVLFKSLPNATLSYYPDAAHGSFYQYPETFAVQANDFLDHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C0</accession>
    <name>A0A654E0C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="8241" checksum="5156E7E408D09D1C" modified="2020-04-22" version="1">MKNITLSIPDELLQKSREYAKKNGTTINNMVRTLLKNTIEGNSDFPAIENSITTLGVKTKSYSFNRDDLYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N5</accession>
    <name>A0A654E0N5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">hslU</name>
        <name evidence="9" type="ORF">MARINOS108_120387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="50"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="8">
        <location>
            <begin position="349"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="459" mass="51262" checksum="B37177AEB97993B6" modified="2020-04-22" version="1">MNKNLTPRQIVAELDKYIIGQNDAKRNVAIALRNRWRRMNVKEEIQGEIVPNNILMIGATGVGKTEIARRLAHLAEAPFTKVEASKFTEVGYVGRDVESMIRDLVEQAVDMVKTTKKEEVKERAKEIVEGIILDALIPPLKGSPTPHATGMGKDQPEDERELNEKTRDRFREKIRDGEMDERKIEIDVKQNSTPGMGMIGGGMDEASMINIQEMLGSMMPKKTKKRKVTIAEARKILLEEESSKLIDMDEVKEEALQKAQNTGIVFIDEVDKIAGGSRGGQGGPDVSREGVQRDLLPIVEGSAVNTKYGIVHTDHILFIAAGAFHFSKPSDLIPELQGRFPIRVELDNLTKEDFLSILKEPKNALTKQYIALVGAEDVSLSFQDDALERLAEIAFQINEEVENIGARRLHTVMSKLLNEILFEIPDTIGQNARIVIDKALVEEKLAGLVKNKDLSHYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R6</accession>
    <name>A0A654E0R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16505" checksum="38572402AF941F42" modified="2020-04-22" version="1">MTGKQKLNYWELNRQLVVFGVIAATLIFPLAWAYKFYFPEPLEPKTEKFCYCLNNDGTTIQARLEYYPEDARRTANRILNNQNVEYRTARGIPINTKVFVIKHHDDVTNIIWRTPNFKGELISTSGWVSSNCLHEQPSYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y7</accession>
    <name>A0A654E0Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16391" checksum="B23145262EFE0C37" modified="2020-04-22" version="1">MKVFLLLLSIVLLTSCHRLENYVQTFEIRNITDHHVSLEYFKYGRSKETVEIGYGGESVLFEIGTFEGKPLGINEGIRTDSMRIIFDSAMVTYHVFNPGRGYWSPHSGNILDDLSYAEDPEHYFTYLIREQEYERAVPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F4</accession>
    <name>A0A654E1F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_11" evidence="3">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29105" checksum="B7A78DD7B085E61C" modified="2020-04-22" version="1">MAVGRSPFQGVSNVLRFNWHFYVVAAIGIMISLLSTQYLIKDWIWIPLAAAGLILLSTLVSLFVTYYIYDLSTLYEFTWLDGTVTNSKIKILNINAGFDETSQILASKFKDSELHICDFYDSKNHTEISIKRARKVYPPHPNTLEVKTNSLPYPDGAFNVVCVSFAAHEIRNLEERIRFFQELARVTSQEGKIIVTEHLRDTYNFLAYTIGFLHFYSKKTWMSIFKSAKLNLIQERKITPFVSTFILASNGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H7</accession>
    <name>A0A654E1H7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein MARINOS108_140144</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="13314" checksum="D17FCC6FB7666689" modified="2020-04-22" version="1">MDTKNKGKYGEDLAVSYLRKKGFEIVERNYRFRKGEIDLITLLNNEVLVFVEVKLRKGDTYGDPETFVSRKQERLIIQAAEDYIFAINWQKDIRFDIISITGSKVEHIEDAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M3</accession>
    <name>A0A654E1M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrous oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026464">
        <property type="entry name" value="NosD_copper_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04247">
        <property type="entry name" value="NosD_copper_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024833709" evidence="1">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="217"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="45989" checksum="18B21A3EACC351F7" modified="2020-04-22" version="1">MRLERCIMLIILFTSLVSRASVTSVCGDCAITSVAEAVRHARAKDTVRVQRGTYVCKNLTIDKPITLIGDSGAILDGANESYVLRLLADSIVVYGFTITNSGRSYTKDFAAIYAYNTSGIWIENNQVSQSFFGILIEKSTGGTIRGNKVTGTATQEDQSGNGIHLWNCDHMQIESNEVKGMRDGIYLEFVDESYVTDNKTHFNVRYGLHFMFSNHDEYRGNTFQHNGAGVAVMFSKWIRMEQNRFMDNWGTASYGLLLKEIYDGEVRNNTFQENTIGVYVDGSARVTYSGNTFRQNGWAVKVSGGCYANAFTANNFIGNSFDVSYNSKMNDNTFNGNFWSAYSGYDLDKDGSGDVPYRPVKLFSYVVNRTPETIVLLRSLFVDIINFSEKVSPAFTPADLVDQTPSMRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T4</accession>
    <name>A0A654E1T4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylan alpha-1,2-glucuronidase</fullName>
            <ecNumber evidence="9">3.2.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gla67A</name>
        <name evidence="13" type="ORF">MARINOS108_11778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of (1-&gt;2)-alpha-D-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans.</text>
            <dbReference type="EC" id="3.2.1.131"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.131" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033939">
        <property type="term" value="F:xylan alpha-1,2-glucuronosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Glyco_hydro_67N" evidence="10">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67M" evidence="12">
        <location>
            <begin position="148"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67C" evidence="11">
        <location>
            <begin position="468"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD14132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="718" mass="81150" checksum="D40851B5E338A145" modified="2020-04-22" version="1">MKYLFSTFLLFALFILPASAETGYELWLRYHKIQNTELLNGYLGQIKSFSVVGSSATHDVIRNELSAGLSGLLGQPFEPSTSSKASLLAGLSDEPTIAQYLSESELTQLGKEGYLVKAISQKESSRFLITAKDPVGLLYGTFHFLKLLQTNQNLASINILENPKVDIRILNHWDNLDRTSERGYAGFSIWDWHKLPDFLDQRYIDYARANASIGLNATVLTNVNANALVLTPAYLEKVKALADLFRPYGIKVYLTARFSAPIEIGGLDTADPLNSDVTNWWEEKVKEIYEHIPDFGGFLVKANSEGQPGPQNYGRSHAEGANMMADALKPFGGVVMWRAFVYSSEEPDDRAKQAYSEFNPLDGSFRPNVLVQVKNGAIDFQPREPFHPLFGAMPKTPVMMEFQITQEYLGQATQLVYLAPMWKECLDADTYVNGQGSTVSKVVDGSLHDYSITGIAGVANTGTDINWTGHPFAQANWYAFGRLAWNPDQTAQQIAEDWIRMTFNNHPKTIAALSDMMMNSWEASVNYMTPLGLHHLMGTGHHYGPAPWVSNLSRADWTPVYYHKADAFGIGFDRSENGSNAVSQYAPEVAKIFNSKDEIPEKFLLWFHHVGWDFEMNSGRTLWNELAFRYQDGVNTVRKMQEQWQSVQPKIDDERFKSVQMLLTIQEKEAVWWKDASLSYFQTFSKRPIPDKVEPPKRSLEYYQSLKFPFAPGIRPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U8</accession>
    <name>A0A654E1U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="67" mass="7512" checksum="80FA7369373604F5" modified="2020-04-22" version="1">MAPSLFKKGLWEAQVPLNSPFFLNISLTDIKMKNIAINPIPSNTVAMRLQFDAKLKNICNLVCLQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X3</accession>
    <name>A0A654E1X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="14525" checksum="7AB962D2B168DD15" modified="2020-04-22" version="1">MIQSLVIGKRGLTKPREHSLELVIEGYYQGITSNDGLFAQINLRADETPAGLSIERNEHICSHDRVSHSQSLVVIVQIVGILHEDIRLSSHHFFLLGGQVFVVCHHRLLAGIPIAHIVGGTTRLLHEHHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X7</accession>
    <name>A0A654E1X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="13990" checksum="D9FFE48930100D09" modified="2020-04-22" version="1">MVYQKDLEVEKKWNALLNTLEKNMGKRPKDLNAVLFLIGVQELGMGAKTYEKEEKQDLMHIAICKLLSFSGFYELEGIDAQGWPHWNLLKPLPHFDLLEQEKLLKMHALEYFNEELGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E222</accession>
    <name>A0A654E222_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil-DNA glycosylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21508" checksum="E2EF1AF9E0098E7B" modified="2020-04-22" version="1">MKTLLSDIRKCTICQSHLPHPPNPVFSASVHSKIVIIGQAPGSVVNRTGIPWDDKSGENLRAWLQMDKPTFYNPEIVALIPMGFCYPGKGKSGDLPPRPECAPQWHHPLLNQMKEVKLTLLIGQYAQAYYLGGQLRPTLTETVKNYRQYLPAHFVLPHPSPRNNIWKARNPWFEQEVVPALRKTIREII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E294</accession>
    <name>A0A654E294_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YHS" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="16846" checksum="46A14DC6458E846E" modified="2020-04-22" version="1">MIKFFSLITLVFLMQEGHLNLDKQGVAMEGYDPVSYFNGKPTAGQSGYFYQFEGARYYFSSSENLEIFKLTPEKYVPQYGGWCAYAMGETGDKVKIDPETFRITDGKLYLFYNFRGNNTLIPWKQNELPLMEKANKNWNTKYVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F4</accession>
    <name>A0A654E2F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase</fullName>
            <ecNumber evidence="8">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acs</name>
        <name evidence="8" type="ORF">MARINOS108_20101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="76"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="516"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="632" mass="70433" checksum="F1D336806C9FF40F" modified="2020-04-22" version="1">MSHKIQTLSGYIHEYQKSVLQPEEFWGRVAESFHWKKPWSKVLKWDFDGPDVNWFVDGKMNITENILDRHLFIMGDRPAIIWEPNEPGDEVVTLTYRELYHQVCQFANALKAQGVQKGDRVIIYMPMVPEAAVAMLACARIGAVHSVVFAGFSSTAVADRINDCEAKMVLTSDGNYRGAKSIGVKSVVDEALEKSTSVEKVIVFKRTDTEVTMKEGRDIWWSDAIKGQPLDCPAEEMDAEDMLFILYTSGSTGKPKGVVHTCGGYMVYTYYSFVNVFQYNVGDVYWCTADVGWITGHSYIVYGPLLAGATTLMFEGVPTYPHVGRFWEIIDKHKVNQFYTAPTAIRALQAYGLEPLEPYKMDTLKVIGSVGEPINEEAWHWYHDHVGKGNCPLVDTWWQTETGGIMIAPIAGVTPNKPAHASLPLPGVQPIIVDTEGKELHGNNVEGNLCIKFPWPGMIRTTYGDHDRCKQTYFSTYKGLYFTGDGAKRDHDGYLRILGRVDDVINVSGHRMGTAEVENAINEHPKVIESAVVGYPHDVKGQGIYAYVICDMEGRSEESLKNEIRETVSKIIGPIAKPDKVQIVPGLPKTRSGKIMRRILRKVASGEADQLGDTSTLLNPEVVEAIVNGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K0</accession>
    <name>A0A654E2K0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplJ</name>
        <name evidence="7" type="ORF">MARINOS108_120508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="19718" checksum="DEDBE0C3B2EA6A0C" modified="2020-04-22" version="1">MTREEKAQVIAGLTEKFQQTDHFYITDTSGLTVEQINKFREMCFKKGVEYKVVKNTLIKKALENLDNDYSSLDSTLKGFSGIMFVNENANIPARVIKDFKKEDKDQRPKFKAASIDSDIFIGEDQLEILSKLKSKQELIGEVISLLQSPAKNVISALQSGQHTIAGLVKTLSERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L6</accession>
    <name>A0A654E2L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="24994" checksum="663E986EE5984603" modified="2020-04-22" version="1">MNLLSFLKIKTAALTMRIFLTDDHAVLIGGLIKIIESEPDLEVVGSAGTVSDTMDQLTQKKVDLLITDYNLPDEDGLTLVRKVRRKYPDIKILVLSMHDEAHLVKEILKEGIEGYLIKKDSHNELINAIYTIKSGKTYLSSDVSKILIKGLNGVEEQRLLTEREREIVKLISKEFTNRQIAEELFISERTVETHRKNIFRKTGTNNLVGLIKFAYANNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N4</accession>
    <name>A0A654E2N4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">MARINOS108_20455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="317" mass="34340" checksum="35C2CB8161A76A58" modified="2020-04-22" version="1">MGLKGFFSKEKKESLDKGLEKTKENFFSKLGKAVVGKSTVDEEVLDELEEILITSDVGVETTIKIIERIEARVAKDKYLNASELNKILREEIAGLLSENNTKDLDSFELPKVDGPYVLLVVGVNGVGKTTTIGKLAAQLKGLGKNVVLGAADTFRAAAVDQLIMWGERVGVPVISKGMNTDPASVAFDAAKYGVDHNADVVIIDTAGRLHTKVNLMSELTKIKKVIQRFIPDAPHDVLLVLDGSTGQNAFIQAQEFTKATDVTALAITKLDGTAKGGVVIGISDQFKIPVKYIGVGEKVEDLQVFNKVEFVDSFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q7</accession>
    <name>A0A654E2Q7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="118" mass="13589" checksum="61A9AE094DAD0AFA" modified="2020-04-22" version="1">MNKAEACLWKYVLRAGGVKGFTFRRQRPVLNYIADFMCKELMLIIEVDGITHTYEEVQKNDKIRQAALEKAGFKVIRFSNDEVLHSINTVAATIEEVASAIMMERGIVARVRKRNREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V3</accession>
    <name>A0A654E2V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="307" mass="35986" checksum="A5C878774C3C39B3" modified="2020-04-22" version="1">MSTASSEPRVLNKPKIKKEISFTLMHFIPFAALLTGVTLFDWMICIFLYFFRMFWITGGYHRYFAHRSYKTSRWFQFVIAFMAQTSAQKGALWWAGHHRVHHRTSDTYDDPHSMKHYGFWYSHVGWIIGPDYKETDYKIIGDYAKYPELVWLNKYYLVPPVVLALTVMALGGIVNGGGIEMMFTSAGFSTLFIGFFLSTVVLYHGTFSINSIMHKFGKQRYKSNDESKNSLWLALLTMGEGWHNNHHYYETAARQGFFWWEIDITYYILRIFGFLGLIWDIREVPDHIKYSKDKEEAKELAKKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E339</accession>
    <name>A0A654E339_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044048">
        <property type="entry name" value="Big_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044023">
        <property type="entry name" value="Ig_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19078">
        <property type="entry name" value="Big_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19081">
        <property type="entry name" value="Ig_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024945437" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="4">
        <location>
            <begin position="325"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="4">
        <location>
            <begin position="414"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="4">
        <location>
            <begin position="504"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="4">
        <location>
            <begin position="594"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Big_12" evidence="5">
        <location>
            <begin position="779"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_7" evidence="6">
        <location>
            <begin position="1292"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="2">
        <location>
            <begin position="1515"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="1678"/>
            <end position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1753" mass="185242" checksum="084F215E384901EA" modified="2020-04-22" version="1">MTTIRRKTPWLTQMVRATFLLFLSIQSSMGQDIASATFVQSKDVFSDISSPGGIWVNSDGTAIFLSGTSFSTEDVVYTYDLSVAYDLSTAVRSVAKTFTMGNSDFTITPHDLVFKPDGSMLFVVGSYFDLNTFDQGDSLYSFSLSTPFDVSTAVLANRARFDISAEEDFTSGVELNNDGSKIFIIGKTNDQVVEYNLSVAYDITTASLGNTFSVNVETGSPESFRFSQDGLMMYAVHLDMGANQSSIFTYSLSSAYDISTATYAGPGESLVLSFSDIRPLGLAFGGESKMYLFGTNDSGSPIREYDLEVAPDDVTPPVVTVDALITNVVSPELTGTIDDPTATIEVTVNGSTYTATNNGTTWTLTAGTISPDLADGTYEVSVTATDAALNEGMDATSDELIIDTTTPVVTIDELITNVVSPELTGTIDDATAMVEVTVNSSTYAATNNGTTWTLDAGTISPDLADGTYEVSVTATDAAMNAGTDATTDELVVDTTTPVVTVDELITNVVSPELTGTIDDATATIEVTVNGNAYAATNNGTTWTLAAGTITPDLTDDTYEVSVTATDAAMNVGTDATADELTIDTTAPVVTVDELITNVVSPELTGTIDEASAIIEVTVDGTAYMATNNGTTWTLAAGTISPDLADGTYEVSVLATDAAGNIGADDTDTELTIDLISPGIEIIDESGNVPTVVNGDFVVLIAFVEPGAESAEAVTGFEVSEIGLTNATLSGDMVSFDDGYLVNISPDGNGDVIIDIAADVAIDAAGNSNTAAQITVVYDIDPPTVTITGALSSIPYDDLSAFSVTFEFNELLGAEDAGFELADITVMNASVANLQVSDDPLVYTVDVTPDGNGDVTIELVEASIQDIAGNAYVGETQEMIPLSTPFNGQGTEESPFEIATKTDLKILSENSIFWNKHFIQTADITFEDSDTYTPIGIYSANPFSGSYNGMNHTISDLQISGSDEIGLFGYSIGVLQNIGLININVLGNDYVGSLVGYNRGEIQNIYATGSVSGAMQVGGLVGYNEGDATMTNSYAAVSVTGAERVGGLVGYNSGAHISFCYATGLVSGQNDVGGFLGLEIFGSVNDNFWNIDQNTIGVGFDDDPAGVTGLTTAQMQDQTEFTNWDFTDTWQMDNGCVNDGYPIFQWQANPEKVTVSLGEDISQCGGTVLLDAGNSGASYLWSTGAITQTIEVTTTGTYSVVVSKENACDGSDEIEVTINAQPEFALATPTPSCGEYTIEGPDGFASYSWSNGETTQSITVTESGTYSLTVTNEDGCTAEDEVEVTVNEIPVVTIAGADTPVCGGFEFTLTATATAGEVTWYDSETKDNVLSEVASLTTSLPNTASFWVEAVNGDCKSELKEVVVNVRYCYSGGAGTVSDPFLISNKKDLDSLMKLTDDYDKHFLQTENISFTASDFAEDGEFYNDEYGVALNTGQFTGSYDGGYHTIDGMVYIFPYVSGLFYYLNGEVRNLGLTNVSLGSGVDPDNGAGLVNILYENGRIENCYTTGALKGDVSRSLGGLVGLMYGGTVSNCYSTASVETIDARNTGGLIGETRGGSIVNSYSSGFVKGATNTGPGVPLFQGGFIGRAAAATVTNCYWDVETSNQTGSAGGTGLTTAQMKDPYSFVDAGWDFKCIGSEEIWDMDLDNINNGYPILGWQSDNESCVLILETEDSKETAIIYPSITSGLVSIRMEGRGNVDHLEVYDMMGRRVLYKDIYVPMQETKIDLSGERPGIYLVRVFSGSTQTTHRVILQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B6</accession>
    <name>A0A654E3B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="28591" checksum="B7A763E96DE4A667" modified="2020-04-22" version="1">MSRELKTILFLSVSAFIMLVIIGFTGVKNGAKPVNNVLVNIQDQNGDFFTDQLEIMSLLNAGNTDYVLGQSISMLDLKALELRVEANPFVKEAQIYRDVKGNLVVNVEQAQPIARIFNRNGPDQYIDADGTLLPTNARHTARVPILELERSFSWAENITETDYGKDILKMLKYVEKDEFWRAQIAQIVIARDGELTLLPQVTKQEIKFGMPDDLEGKFKKLKIFYKEILPNKGWNTYSLVNLKFKDQIVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G9</accession>
    <name>A0A654E3G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13633" checksum="4197EBA09139CB4B" modified="2020-04-22" version="1">MKKKSSLEAKESRLKDELEEASENFESQVKKVVIISLISGGVVLAGYTLFRALTKEEKLADPPTPAKKAVAKPQQIKVDQGFSVKKLLMEKVTLAAIQFVGTQLAMILSKKMGGQTEVKKNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L2</accession>
    <name>A0A654E3L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, sugar porter (SP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="48799" checksum="C73E8E25AC24D5C0" modified="2020-04-22" version="1">MKGKLIFAALAASLSGFLFGFDTVVISGANLPIKELWNTSEWFHGTFIMSMALWGTVVGALLAGFPTDRLGRRSTLIWIGVLYFVSAVGSGLAPDPYTFSLFRFIGGLGVGISSIAAPTYISEISSASNRGRLGALYQFNLVLGILVAFISNYLLQGVGGENDWRWMLGIEALPALFYTIMVFGVPRSPRWLVLYKNNTTEAFEILKGLTGSEERAQSMLKDIEEDHQRTAHDTSSVFSAKYKRPLILAFLIAFFNQLSGINFILYYAPEILVKAGFGASDSLLSSISIGVINLIFTFVGMSLIDRAGRKQLMYIGSVGYIISLFMVAYGFYTDSSAIFKLVFILTFIASHAIGQGAVIWIFISEIFPNRVRAYGQAWGSGTHWVFAALITLFGSVLINSFAPWVAFVFFGCFMVLQLLYTHFMMPETRGKSLEKLEEELVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y0</accession>
    <name>A0A654E3Y0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="14807" checksum="5BF008D30D7CD7C2" modified="2020-04-22" version="1">MGNAKLDRIFTKAKETVTQNEKVKSLLTEVKAKMDKINTDSEERSTFIYQIQVLVRMIRAHFNGKYSAFSTSTILTLVFGLIYFITPIDLIPDFIPALGLTDDISLIYFIFRNLAEDIGRFRSWEETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E430</accession>
    <name>A0A654E430_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="20140" checksum="BD55CA79D1CBC7A9" modified="2020-04-22" version="1">MRNTLERPPKTVMEVYQSLPEGTLAELINNALYMSPSPTSGHQVVLNDINYELMSHFRETKTGMVLIAPLDVYLDEKNNAVQPDITVILNHNLSIVNESGHIHGVPDMLIEVLSPGNRDHDLIRKKDLYESFGVKEYWVVDPENKHALGYSFNKSNYELIGDTIGSIDSPLLKLKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E438</accession>
    <name>A0A654E438_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_50037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21396" checksum="3897FBDF28BE644D" modified="2020-04-22" version="1">MSGCVGYQVSQLIQEILKGDRRAQGRFYDEFSPLVMGICMRYMKSHEAASDVFQEAFIKIFNNLGQVKNMQAVAGWIKKITVNTALDHLRVIRYDHDVGSEGNELSDQFYSDLIDKLSTEVILQAVNNLAEGYRVIFNMSVIDGFSHKEIANELGISESTSRSQLTHARHVLKRYLNELGITRYEQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E469</accession>
    <name>A0A654E469_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024961295" evidence="1">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="335" mass="37665" checksum="29A0B7308BAD352F" modified="2020-04-22" version="1">MRTKLLGFLSAILLLSITSCDESTDTSEYGNWVKQSDFEGVTRSGAISFSIGNYAYVGLGSDGDDYLTDFWRFDPSKNFWQKMASFPGVGRLSTVSFSLDGKGYLGTGYNDDLDEEELNDFWEYDPDTDTWTQKADFPGSKRYAAVGFALEGNGYIGTGYDGNYLKDFWRYDPTSDSWTQVVSLYGSKRESATAFVINGQAYIATGRNNGVYLYDFWRFDPSDESWTDLTLYDEDDTYETYLSAISRYNGVSFSVDGLGYLATGISDSYTSSVYSYDPDANEWEDDITAFEGSSRSNAVAFVVSNKAYIATGRNSSQRFDDIWSFDPLAEYDEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E470</accession>
    <name>A0A654E470_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="19012" checksum="60B0F381727F8C29" modified="2020-04-22" version="1">MIYEEALKQARDQQKANKAFLKTLKRIKPKNLDNQFHTLHEEAFEEIDCLECANCCKTTSPIFQMADIERLARTVKMKVPVFIDTYLYLDEEKDYVLKSSPCPFLGADNKCIVYENRPKACREYPHTDRKRMYQITDLTFKNTLVCPAVSQIVRKLSESYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P8</accession>
    <name>A0A654E4P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="28"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34629" checksum="63B73C6B0D5E955C" modified="2020-04-22" version="1">MRKIIFFVGSLVMLTSCFGPKKNMKESFDLQGHRGCRGLMPENTIPAFIRAIDLEVTTLEMDLAVTKDRQLVVSHEPFMSAEMCLDSLGNEIPETQQLQYNIYQMTYQEVASFDCGSKPHPRFPEQQKMQVVKPRLVDVIDHVEDYLKVNGKPPVAYNIEIKSQPETDDLFHPAPPTFSELVYAVLDEKLDWSRTTIQSFDFRVLQYFHERHPKVTLALLIENDLTVEENLDSLGFTPDIYSCYFPLLSRESVDLLHSRDIRVIPWTVNEVTEMKDVMELGVDGLITDYPNRFNSIKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S4</accession>
    <name>A0A654E4S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_50101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="800" mass="89992" checksum="D376ECD741CC0E21" modified="2020-04-22" version="1">MTPEYIKTTVRSLAKNKLISFINIVGLAVSLAAFFFIYRYVMKELSYDQGHPHYERLYRVAELIESENYLENSSSSPWPTGPAIVREFPDDVEGMVRFFDFQTPIITITLEDQRKFNERYIYFTDSTVFDLLDFKLIQGDRSALSGPFSATISKNLAEKYFGDENPMGKKITREGFNTTYTITGVYEQGSISHIRTEMLLSMQTLETNAPFLKTQWVWNPAWTYIRLSENASVQDLEKNKFPLMVEKYYDPRTKDKTSHYLQPIQDIHLGSHLEFELSANSDMKYVYIFISCALFLIVIAIVNFINLSTSFSLLRAKEIGVRKVSGAARSQLIFQFLSESVIISLIAYVLALIGCYIALPFLQGLINISFAELFGLNNLLFQLGVVILVGLVSGIYPAFFISSFDPLLVFKGKFISNAKGQLLRKGLVISQFTIAIVLIIFTYVTYQQLQLLRNQDYGYHTNDVIILDAATTNLGQRIEGFKTALKANASVESITTMSDMIGANNNNHDFHHEGMQPGTWNFYPALLVDEDFAGTLGLEVVAGRDFNRNHQKEDSLAVIINVAMAKTLGYATPEEAIGHPLRSLSGNENIVGVVRDFNYKSLHSEIGPFVLDIGQRGPNGFFFFRHVAIKVSEVNNQTLGHIQNIWEEFVPNKPFTYKILSEELRGLYKSENNLGQILGVFAVLTIIIACLGLFALATFIAQQKTKEIGIRKVLGAGHLKLFMVGYKEQFFLVLGSLILATPIALLLVRNWLSDFAYRVDLGPAPFLTAGALAILISALTVFSNFYKTITADPAEVLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V2</accession>
    <name>A0A654E4V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024908869" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="21974" checksum="975EA860B04B391F" modified="2020-04-22" version="1">MKYTFTLLVSIAFAIMVSAQETPPTSYEEIPDYPAEFTAETVEARMVDGLGFRYYWATEGLQSEDLSFRPGDEARSTRETLEHIFGLTLVLVNSTRMIPHSSEEVMDLSFEELRAQTLANIAEASQTLKSEGARLEDFQVIFQRGEAQTIFPFWNQINGPIADALWHVGQVVSFRRSSGNPLNPNVQVFIGTVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W6</accession>
    <name>A0A654E4W6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="168" mass="18849" checksum="82AA877128C56B51" modified="2020-04-22" version="1">MIAAQNLILSEVQVNQIIRRIAFEIYENNFDEKNIVVVGIYDKGYLLAERIVRELSAIAEGVKISLIKLEINKEKPLASEVTLDVPSKNLKGKVIILVDDVLNTGKTMAHSMSALLEVEVKKLQIAVLVNRSHKQFPLSANYKGYELSTTIDEHVDVKLEDPVGVFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X9</accession>
    <name>A0A654E4X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="14333" checksum="76CB9C930D69AF31" modified="2020-04-22" version="1">MGPTKSNDQEIRIDRLETERPGGKTTGPFCLKYCHVLKLVDSSLTIVIIPSESSIAQRNYNLNFKLSVIFSGRKSEMPYTRNPSFQNPFILLYDWSTLRCLRLFWNEFLSSWVWIKIYLMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E500</accession>
    <name>A0A654E500_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lptB</name>
        <name evidence="13" type="ORF">MARINOS108_140029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="27319" checksum="EA70F95A235C218A" modified="2020-04-22" version="1">MELRAEHLIKKYKKRRVVNDISVSVNQGEIVGLLGPNGAGKTTTFYMIVGLIKPNEGSIFLDEENITDLAMYRRAKKGIGYLAQEASVFRKLSVEDNILAVLEMTKLSKVEQKEKMESLLEEFSLTHVRKNLGMVLSGGERRRTEIARALAVDPSFVLLDEPFAGVDPIAVEEIQTIVAQLKNKNIGILITDHNVDETLSITDRAYLMFEGNLLKAGTPEELAADEQVRRVYLGKNFELRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5J1</accession>
    <name>A0A654E5J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/glucose cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT</name>
        <name evidence="8" type="ORF">MARINOS108_11197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="612" mass="66504" checksum="44E09F109A98CA63" modified="2020-04-22" version="1">MGFSTLDYIVFGIYCAVILFMGLYVSRDKKGHQKTANDYFLASNSLTWWAIGASLIAANISAEHFIAMSGSGYAIGLGIAAYEWLAAIALILVAKYFLPIFLEKKIYTMPQFVNDRFSKLVGSLFAGFWILVYIFVNLTSVSYLGALAMEKIMGVPLTYGIIGLLVFSGIYSIYGGLSSVAWTDVIQVIFLIGGGLVTTFIALDVVGNGDVFRGFNYLYEGARGHFSMIIAEGAKSVPDGSGGLKDAYNDLPGLAVILGSMWLINLGYWGFNQYIIQKGLAAKTLQEAKRGLIFAGFLKILIPLLVVIPGIAAYVITNDPELAKNTVGEITKSDEAYPWLLQNFVPAGVRGLAFAALVAAVVSSLASMINSTSTVFTMDIYKAYISPNADDKHLIRTGRLMAVTAMVIAMVVAPALKSLDQVFQYIQMVTGFVYPGVVVVFGLGLFWKQITNKAALWTALLTLPTGIFFYLVTPELPFILRMGYVFMILCVVASVISFMDKGVKISSVVPTGSVQRKLVNTSYLLFAIGVITLILGVFLSAPLAKYGFEAIFVISTLFLMLGMVIYTNAKMDVQDAHAISVRPTLFKTDVVFNVGAIGIIGIVVILYTLFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5T3</accession>
    <name>A0A654E5T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="20269" checksum="F4B122ECCEA4805E" modified="2020-04-22" version="1">MRQIVYYVASSIDGFISGPNEDIGGFVQSGNGVDQYRADLASYDTVIMGKNTYEFGYQYGLQPGQPAYPHMKHLIFSNTLTFESADPQVQVKNIDLAEIEKIQKEAGTDIYLCGGGVFAGWLLDHQKINILKLKLNPLILGQGIRIFGESTQKYGLVLLDTVPYENGLQIMTYRIDYENKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5X7</accession>
    <name>A0A654E5X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025006879" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="118"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="391"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111404" checksum="DC5134CEB6852F9A" modified="2020-04-22" version="1">MMKNYTKFLSLCLLALLSTGLFAQERVIKGTVTSEDGPLIGASVVEKGTSNGTITDIDGNFQLLLAGENTKTIVASFVGFQSREVTLSSAQTQIEVMLEVDYASLEEVVVVGYGTKKKVNLTGSISQVDEQAFKGKSVTNSYQALQGEAPGLIIQQGTSEPGSVPQINIRGLSTINGNTPLIVVDGVISSLNNVNPNNIESVSVLKDAASAAIYGSRAANGVILVTTKSGEPGKPKFTYSTMMGIQQPTNFPKAADSWEYATLRNEALVNSGLSPAFTPEQILGFKENGPNTFHYREIFKDQAAQSSHNLSMSGADNGLNYFMSLGYLDQNSLFKGPDYGYKRYNFRINLSKEISDKLKVSGRMSFARNDIKDHAWWTEWLIEPTVRIPTIYDIVDENGDYTLVSGSNGNSLARLEQGGSRTSQNDEALGNVSLEYKPIDGLTLRGVLGGNITSNQTHQFRKAITYAYPGGGDNQNSVTDQYSRSLYLNPYVTANYQLELFDNHEFEVLIGASSESFKTQFFGVTGLDVPGNEFGVIGNTSEILQSETYGSANDWAINSFFGRVGYTISDKYLFEANLRYDGASRFSDENRWGTFPSFSLGWVASNEAFFQPLTSVISFAKIRASWGKLGNQDINDLYGYQSLVSASPNIYAFGNVGVPGSFYSVSNASRTWETSTMKNIGLDLSFMKDQLNLSVDVFDNLTEDILLQLPVPDIYGLGQPFQNAGSVRNRGWEVALDYRFRSGSFNHSFNVNVSDNLNEVVDLKGREFISGGDVQTILREGYPMYSYYALMSDGFFNSTEEIDASATPIFATSVKPGDIKYVDRNGDDEINYEDDRFIVGNPFPRYNFGFTYRAEWNGLDFSLFLQGLGKRSQWVRGEIVEAFHNSNEGPVFKQHLDRWTPVNTDASYPRLTIGSESVNNAARSDFWIFDAKYLRIKNVQIGYTLPETWTGKIGMSNARFYVSGFNLLTFSPFDIGLDPEVNGSLSGAGAPYSGRVYPVSRVISAGLDINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E667</accession>
    <name>A0A654E667_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4960 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032526">
        <property type="entry name" value="DUF4960"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16324">
        <property type="entry name" value="DUF4960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024940552" description="DUF4960 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4960" evidence="2">
        <location>
            <begin position="125"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="420" mass="44148" checksum="4838BE6E47C83EF3" modified="2020-04-22" version="1">MKKSILFYAVMIIATVGFIACGDGGEDPAPSLEITSITATSADITRTGVVDAAAGTVIFQPFPPRTDISAVTIAVTLPEGVTVSPASGTAQDFSAGAVTYTISNGSEELSFEVSVTAEFAASIAFVGDANAPGSIKEKDMAAAYAYLSGEYGDDLEYIPFSSVNTDALQYIEVVVYYQDSDPGNNPGLLESIPASARAASVVDAFKAWHAAGGDFVLAGHGTQYLNQLGRIPDDAGKPYEENGWAPRIYGSGDGFENPDQWGINVNLNVNAIETVSSSDWDRSGHAILEGCTTSDIANPVDQTSYGHPAIPMIAAGYKEDHNSMWDINAAPITDHVDAFDKADKWEAAMEATLIGTWGHVVDLCCGAVVELHARASAPAEGSIIVIGAAAYEWEQNGADNAFMSNNAAMTVNSINYLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7I6</accession>
    <name>A0A654E7I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative addiction module killer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014056">
        <property type="entry name" value="Addiction_killer_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41791">
        <property type="entry name" value="PTHR41791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028744">
        <property type="entry name" value="Addict_mod_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02683">
        <property type="entry name" value="upstrm_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="10331" checksum="C9D173D3A3CFE273" modified="2020-04-22" version="1">MKDQRAKAKILFRIQRIEEQGNFGDCEPVGQGISELRIHYAKGYRIYLREYNGRVVILLNGGTKSSQQKDIDKAKVIWLNYKDELEDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9Z5</accession>
    <name>A0A654E9Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19326" checksum="5B8EA85F4AD5F646" modified="2020-04-22" version="1">MYRLTILILWLGLGSCDLGLDSPNDVSGDYYNSDLMISFRDSSGQDLLDPDTPGYYDTAQMSLFYEVDGELEEVYLENNDLPKQFTLLENVPQNEEPFRLYVSADLRLTSGNTMTYLQLSPADMDTIVCEYEAETGKSENYSYIINVWYNGEQVFPTNDSDIAYFTIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA55</accession>
    <name>A0A654EA55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">X-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="433" mass="49940" checksum="BF6037A565938821" modified="2020-04-22" version="1">MRYGQIDQQLFVENRKRLVSRLKPHSVVIIHSNDVMPTNADGTMSFKQNSDLFYLTGVDQEESICILAPDFPDEKMRELLFLRETNEEIAIWEGHKLTKEEGQEISGIQNIKWNQDFEKMLYTILAETEHIYLPTNEHIRNASLVETANDRFIKQCMSRFPLYKYERLAPIIYDLRTIKSGIETKLIEHACHITEQGFRRILETVSPGVWEYEVEAEYAHVFLSNRSRGFAYTPIIAGGANACVLHYIENNQQLKDGDLMLMDVGAEYANYNADMTRTIPVNGRFTKRQRQVYDAVLRVKNQATELLTPGSAIPEYHKAVGALMEVELIELGLIDKTDVKNQNPDWPAYKKYFMHGTSHHLGLDVHDVASIYKKFEPGMVFTVEPGIYIREEGIGIRLEDDILITENGHKNLMRNIPIHAEEIEDLMNESRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAH6</accession>
    <name>A0A654EAH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA carboxylase, carboxyltransferase subunit</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pccB</name>
        <name evidence="3" type="ORF">MARINOS108_120461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="528" mass="57911" checksum="5E6BEE3E74A9F280" modified="2020-04-22" version="1">MSSEKPKTASFVKSTHQKIEELEQMNEQAMLGGGQSRIDKQHEKGKLTARERIDLLLDPGSFQEIGKFVVHRGRDFGIDKQKFLGDGVVTGYGTVNGRLIYVFSQDFTVFGGSLSETFAEKIVKIMDMAMKNGAPVIGLNDSGGARIQEGVVSLGGYADIFYRNTRASGVVPQISAIMGPCAGGAVYSPAITDFIFMVEQTSYMFVTGPNVVKTVTQEDVTSEELGGASAHSVKSGVTHFSSKNEAACILDIKRLLTYIPSNCEEEPPRLPYEMNGDEVIPALDDILPDNPNQPYDIKDVIKGVVDKGSFFEVHEKFADNIVVGFAHLAGRSIGIVANQPMSMAGVLDNDCSKKAARFVRFCDAFNIPLLVLVDVPGFLPGTDQEWNGIIMNGAKLLYAFSEATVPRISVITRKAYGGAYDVMNSKHIGSDMNFAWPTAEIAVMGAQGASEIIFKREIDKAEDPHQKLQEKIDEYTEKFANPYKAAERGFIDEVILPHNTRSKLIRAFSMLENKVDNMPKRKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAR7</accession>
    <name>A0A654EAR7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="347" mass="40921" checksum="6E329007895E7DA0" modified="2020-04-22" version="1">MAIISKKKIPYKISTRLRAYLNKYDREIALPIAYDSLLRYDNSIPLYDRNGNDTLWETVLYPQDDMADIYFALKKIYSIMKADGDVGVMDHLFIDRVDLCVYGNTQPFRVRIVNRINDNFDYFYIKNADASRIYGLELEHLLSPNKISYVVYKDTLIEEHIVGIPAEQFIKNHLKDPNLNETRLAKEFVKFNERCFVRLLGDMHSSNFVIDITPDFEEVDYRLRAIDFDQQSYEGRRAIYLPQYFKQNNPIIKIGLKSLTPETVRQYQREERSLIANRVKVEKIRVDDLLSAMTHDRISKPGNVARLGEELAEFYEETEFIHCKNMGELVEMSLEMLIKKPELYKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBY9</accession>
    <name>A0A654EBY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="52" mass="6062" checksum="EC926E030325EC60" modified="2020-04-22" version="1">MRTTSIMVSILLFRLIFLVPISQMYEITAIDGRPNYHGSYSRWKSLQNIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE91</accession>
    <name>A0A654EE91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator in two-component regulatory system with PhoR (Or CreC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoB</name>
        <name evidence="6" type="ORF">MARINOS108_20937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="228" mass="25914" checksum="A69321E53F7D5BDA" modified="2020-04-22" version="1">MAKNAQKILVVDDEADILELLKYNLIKEGYDVKIALDGIKGVDIAKSFVPDLIILDIMMPKQDGVETCRQIREIPELANAFVIFLTARSEEYSEVAAFDMGADDYITKPIKPRALVSRINALFRRESKKKKESNQISIDNLIVDRTSYTVFVGEEKVSLPKKEFELLYFLAQNPGKVFSRDELLQNIWGTDVYVLARTVDVHIRKVREKIGDGYISTVKGVGYKFDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEZ6</accession>
    <name>A0A654EEZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024816730" evidence="1">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="30955" checksum="C27A22B0FE78C337" modified="2020-04-22" version="1">MKLSLFSLIILGGLLCQAQVKEMQLQDRLPIAPDRPITVVIDNVFGAIEVTASSAPTVSYEVLKTINADHETALEKGLSEVNMKVVQRNDSIIFYLTAPFICDHWSGCYQRGRWMDGPEDYSFTFDYQLQIPASANLKVQTVDQGKVTITGITGMVSAENVNGDVEIKGAHSVARATTVNGDVEVTFQKRPNLDGRFSTINGTINLYCTSDLSASVTAKTMHGSLYSAFDFETKKPELKKVVSKKGTSTTHQLNETFGIEIGKDGPTLSFETLNGDIYLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSL6</accession>
    <name>A0A654DSL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Imidazolonepropionase-like amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="434" mass="48544" checksum="91C1B6468C37AD19" modified="2020-04-22" version="1">MTKQITTYIIGIILGWSAYAQVLAPAPAQSEPIAIMNATAHLGNGEVIENSIITFKEGKITLVADATRVRVDLKGYRLIDAAGKHAYPGVILPLTNLGLVEYEAVKASRDFSETGNLKPHVRTAIAYNTDSELIPTMRFNGIQLAQVAPRSGRIEGTSSIMQLDAWNWEDALYQEDDGVHLNWPSLSYGARWWMGETERRENKEYDAQVAEVTQLLQDTKAYLEQSSEEKNLILEAMVPVLKGDKQLFVYANRPKQIIEAVQTIKQYVPKMVLTGGEDVWYVRDLIKENNIPVLLENVHRIPGRAEEDTDWCYKLPAMLHNEGILVGLTHVSEMIASSRNLPFFAGTVAGYGVDKETALQMITSNTAKILGIDDKTGTLEQGLDANIVISNGDLLDMRTNDVVYSFIQGREVSLDAMQQRLYEKFKEKYEGQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DST1</accession>
    <name>A0A654DST1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024997456" evidence="5">
        <location>
            <begin position="31"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="291"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="765" mass="85449" checksum="FA6D3FAFC7D1CD63" modified="2020-04-22" version="1">MRLLASFIINPMKLPSILVLLLMLWHQSHAQTTISGHVKDGANEEALIGAIVSTGVDTTVTDTNGNFHLSVRAFPVTLRVNHLGYQTLTIQMRAPKEITLALEPSSLTLNDVIVTSGSFSRKTLNTPTSIQSINQEMLRRDDPFSVTSALNRTPGVYMHAGTLTTNRITIRGIGSRSLYGTNKIKAYYEDIPLTDGSGNSSIEDIDQEMISRIEITKGPNSSAYGAGLGGAIRLLAPVPSAQQTSAKTSLTMGSFDTHRWMLQGAHHDNKTTVSVVYSDLQRQGFRENSAYSRQQAGVTLKYQLTPQSYFSVLGIFTHLKAFIPSSISEDDFKNNPEKAAFTWKQAKGYEAYDKTLLGLSYHQAFGQDWSLKSTLFLKNRDAYEPRPFNILDEETFTIGTRNTLAKRWENFRFFTGMELFFDEYRWKTFENNYDENSNGSVKGDPLSNNLENRSYFNAFIEAAATLAPNLNATAGLNLNFTHYTLDDQFNEPGNNISGDYAFNPVVSPKLGLTYVTGAHNTLFMNVSHGFSPPSLEETLYPDGQINPDILPESGWNYELGVRGTQRRFTYDLTTYYMQIKNLLVAQRISDDAYVGVNAGLNNHLGVDLLGNYYFVLSDRYTLNAFASVAYMNYHFDEFVNDGNDYSGNELTGVPQWIFNPGVELLSDLGFYGNISGQLVGEIPVNDENSLYAERYFILRAKAGFRYVIGPWELDMNLGANNLSDTKYAAMLLINATGFGGSQPRHYYPGNPRNYFGGVSLKYTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSZ5</accession>
    <name>A0A654DSZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="271"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="384" mass="43909" checksum="6A154549571858DD" modified="2020-04-22" version="1">MEYLIVAGIVLSVLLLTVTLSKKNKQTPDKHLILYLGFATFWQAYFYLETLSFLQASPFMLLGKGLYLLNAPLFFAYVYVLTTSRRLTPKLSAILFSPFAAYVIHFMYFHFLVFDQADLSIKSGLLFIDGQLALSWLFFVILFLLIEPVFLVWFYFLLKKYKQRLLQSESDLSRIRLRWLYLLFYLCLIISLFLIPASMLSLGGGLVSTDLLPIMMQGATVLFLFIVGYYGFRQTTVFANPALDLTTEDQMKNGSYQRSGLSDGQAAIYHAQLLTLMEEKKPYLNGELKASELAQMLDISVNHLSQVLNNIQQQNFFDFVNGYRIKEVIKKMEAPKNSHLTLLAMALDSGFNSKTSFNTVFKKMTHQTPSAFYKSLTSSLQEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTI5</accession>
    <name>A0A654DTI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding motility-associated-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="556" mass="62278" checksum="B1DCDE34C742B326" modified="2020-04-22" version="1">MSRKFNQDSLVSLNISNDYLRVLLFILNFICFAGIGQHTSNFGRFSIAYPQGCAPVTIHISEHDNLGTISRQYFYEEGAIETTDTFHTYTEPGRYEVVQFLGEDIQPKTDTLIFEVLEAIPPALSIFQCSETEITVGFSDEYYDYYRVWFSETDSVTYVPGDGLPTYDYGQSNGMIQAVGYFNNAFASCPDISQSFNLQSLQPLNINSAEITEACLDDLYLQLSLWPSPDPLTLYSVELQTNGATFETIHQGKLTTSTPSFHLGTDLQIDEFCTRINIFNPCTETILFTQESCDSAGSTTKNLLESYATYSGDDILIHIDSSSSKEVEIKRKYGDGAFSLVATTQGDYTDDVPPGARPFQYRLIQQDSCGNAIDSIVVAPPHIKLTDRSYSENRIQISLSPPQNALGSYTQSLLFYNDDSSRVIETNFDTNILLPGGLGTSIHLRVRYSYDNDLFILSNALTEAYEITVFIPSGFTPNGDGLNDYLELFGLPTSDFDIIIYDRWGAPIHQSNTNPVWHGEIGKHDADEGTYLYRLTFRLENGELKTQVGTFTLLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTL7</accession>
    <name>A0A654DTL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyprenol monophosphomannose synthase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppm</name>
        <name evidence="2" type="ORF">MARINOS108_10378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="249" mass="28286" checksum="A0BBC85FD0152B3D" modified="2020-04-22" version="1">MHKNLVIIPTYNEKDNIREITAAVMGLAVPFDLLIIDDGSPDGTAEIVKELQTQWPEKLHLIERAGKLGLGTAYIRGFQYALEHGYDYVFEMDADFSHNPQDLISLYQTCADEGADLAIGSRYIKGVNVVNWPMGRVLMSYFASIYVRLVTGIPIMDTTAGFKCYHRSVLETIDPEKISFIGYAFQIEMKFTAWKHGFKIVEVPIIFTERAKGSSKMSKGIFKEAVFGVLEMKIRSLFRKYEPHQSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTT0</accession>
    <name>A0A654DTT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="855"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1046" mass="119731" checksum="71BD8C149729124A" modified="2020-04-22" version="1">MVYGIIWAWIFFPFSGFSQVKYDWKPLPDVKAIKSYSDQFHAQVKKHPPDPAPPVIREVYLDEQPEFVTSIQPDLLSRLHFEAYELTLDQRIDIPNGMVFKDISNSNIKYLDQAHGLLTNDISVIAEDKDGLIYLGSSKGLLVFNGKELSVYQGNAAFSLTGIRSLWFDAEGKLWVATDINICYIQNQKIFVPEMDFGPTHLQGFSESSATGEFFIFTVYHGLFILKEGQMYQYNAGLPTPHVSCAIRTDDGRLWFAFGNSGFGYIQKDSLFMYKREGIENSPRSLLEVGGELWLGQFRGKLMKHRNDSLFNVLLNDRRRHHIYSFAPNEQGLWFPDYAEGVYLIKKNGEYDFIGEEHGLNGRVSFTLMADSFENIWVADAGNGISRIDELAFRPTRKFVSNHGIFQIEPDAYGNSWYFMNGGGLISESEVGYVEYLNSDRYSTSGAVSGDSVWISSETLGLTLLKDGVFTTYRMKKDEELDSTIYDIKMDANARIWGWNYANRLYSFRNGQFYNFSSAPDLKDFKFINVLQTADKTIYAVALNNGVIAISNNKYAHLNMGNGLLSDQISFVFQDESGNTWFCASGRVQVVDAQGQSTVYQIKETESNPILQILETEKGSFMATTASGLLLMEKDQEGLTHKFYGKENGLKLIGNRMITRDRQGRILIGGGTSLKTFDPYYLKSDKSRPRLTLNRVLADGVEVDRDHLEVEQEKVVNFVFNKIFWGQQSDLVYKLQHRSRSGNWNHVSSNVISFKELQYGNYELLVYAEGEGRKSEELQFKFTILPFWYQTDGAKLMYFLLAVTLIVGYIFYRESRARIAKIRLQKLVDERTAELQVEKLNVVRQLQQKEILMQEVHHRVKNNLTFLKSLLYLRARASKDAEVRLILDECQARIQSMALVHQNLYDVQDASEVDFDLFLRELFFELESMFDQDRSNINIELAVSDFKVDVKLSVFLGLILNEMITNSFKYAFPNGEEGRILVRLSQMSEHFELTYADSGLGFGESFDFKTSTGFGFKLINILLNQIDAQMQYVNNGMTTFTIVIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM2</accession>
    <name>A0A654DUM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="4860" checksum="092FA20EACE6FEB3" modified="2020-04-22" version="1">MSKNFIATFPIYKCTIFATTIPVFALHYSSTNTGMRMEHSSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN6</accession>
    <name>A0A654DUN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="82" mass="8954" checksum="C5C1FF26D7EAB1A0" modified="2020-04-22" version="1">MPPTFTSKIFWVGCSTHPPGDLRLENGEVFRSIVVLDVLPGVGSSSDEQLSSVKPKLARTVTKLAFFINALLSISKYSELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU4</accession>
    <name>A0A654DUU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="41430" checksum="1A911861CB25D933" modified="2020-04-22" version="1">MIYRALICIFILAGCSDHQRYPISEVSVGPDYYLTALKAINSEIRDKPKDVLLRKKRLFINQKLRWPEEADDDLNFIISNAGLDQEVYLYGQDYFRTHHLYEKMLDYVAHWEELNGFSGDNLQWRVIALSGLGREREAQNHLWDLIQVSKEDPEKLAFAARTYLKMEDTTRALYAFSNLSRANSDHPSVLHAYVPLLLEHNQFEEAGKVLERLQINVDDAEGQILAAKTLYELGRSEQAHSRLRVLNSLEVYYQRAIWYKQDNQWDSATYYLDLVIQEDSSSRALLAKAEIFENQGYLNQSYALSSLVFEKDSTNSIAEEMARNVGRKIAYLRSLREREKRIPILDISSKKETENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV30</accession>
    <name>A0A654DV30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14335" checksum="6C06FA70399E3704" modified="2020-04-22" version="1">MLVSSVGFSMNTHFCGGEAVETSFSIGLHNPDCGMPDMDRECESIPSKEKQIKQKPCCENQHQLLQLDENADVQITSIEVNPVFLVAFIHSFVQPVLFADQSFIHNTYYSPPIPDRDIQVLFQTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV76</accession>
    <name>A0A654DV76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="31366" checksum="BF9DB156CDB3BC92" modified="2020-04-22" version="1">MKILKLMAMVSLTTLLWSCGSDDEVNPDEFGTFQLYFENKVGANSITLRAPGSTDYDYETSDGEPFNLSSLGYYVSKITLEGPNGEYFQDEISVNADEAKGYYLLKESNSISRNILLEKVPAGTYDRITFTIGVEEDGMKEGAAGGVLDPAAGAWFWNWNAGYIGLMMEGTAEHSGQAYVDHGNGVEVLEKTFGFHVGGWKDVTDNENFVNNIKTITLEFGTTVTVNPHLSPLAHLITDVLKVLDGAEVDFSTTYSIHSPKGGKVLADQLLNAFSVHHVHQSTSSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC7</accession>
    <name>A0A654DVC7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024963122" description="Abhydrolase_2 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="33494" checksum="E365977360832DE4" modified="2020-04-22" version="1">MKYFLASFLLMTVCFLEAQSFERNTVVYEDTLGMDLYTPKDVAAPRPLLIYVHGGGFSGGKRDESGHLAFCERYASKGWVTATISYHLTMKGKSFSCDQPVQNKISTIFEAARNIHQAVAYLIDRKEELGIDASRVVIIGSSAGAEAAIHATYWNETMAGILPSNFKYGGVISMAGALLDARWITKENAIPTAFFHGTCDNLVPYANAPHHYCDAEQTGFMMLSGSYTLAERLRSLDQQYYLMTDCGGGHEWAGKPIQDGYISIIDDFLENDVLDARHRQTHIIYHEGKRSCDSELSFCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVH3</accession>
    <name>A0A654DVH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="24659" checksum="6664EBC840275E68" modified="2020-04-22" version="1">MYMAICGNIGSGKTSLAEKLGHHYGWDVLYESVDNNPYLADFYENMEKWAFHLQIHFLNSRFSQIKTIQDNKQSAIQDRTIYEDAYIFAMNLKKSQLLNERDYETYLALFNSMIEHIHAPDLLIYLKADIPRLVSQIQKRGREYESAIRLDYLKNLNEHYAEWIGNYDQGNLLIIDVNNLDFVNRPEDFSFIVERIDAEINGLFSNKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW05</accession>
    <name>A0A654DW05_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">uppP</name>
        <name evidence="15" type="ORF">MARINOS108_11175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="28611" checksum="E81707495A82C088" modified="2020-04-22" version="1">MTWIEALILGIIQGLTEFLPVSSSGHLEMGTVLLGVKSEENLLFAVIVHAATALSTIVVFRKDIGEIIAGLFQFKWNESWDFGIKIIISMIPVGIVGVFFEDEITALFTGNLLLVGSMLLVTSALLFFSHFKKNNEKPVSKPHALIIGLAQAVAILPGISRSGATIATALLLGVEKNKATRFSFLMVLIPILGASMLKLKDYFEAPAAYEGLSGPSMVVGFLAAFLAGYVACKWMIGIVRKGKLTYFAAYCLVIGLIAIISQIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW30</accession>
    <name>A0A654DW30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MATE family efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="452" mass="49066" checksum="AACAD86E765C794F" modified="2020-04-22" version="1">MKAHKKDLTTGSIPKKLIGLTLPMMMGILSMVAFNLVDTYFVGKLGSLQLAALSFTFPVILVIFSIIQGLGIGATALISRSIGRNDRQKAARETTDSLVLSVLIAGVFIVIGLFTITPTFRLLGASDEILPYVIEYMSIWYLALFFVIIPFVGNSAIRATGDTRTPSLIMIFAVLVNAVLDPLLIFGYGPFPELGMKGAAIATAISRAMTMVLSLWVLARREKLIVKTIPAWKTLLGCWKAILHIGIPSGLSKMIVPITTGVITALLAGYGDFMVAGYGVATRIEFLSMSILFALSASIGPFTGQNFGAYHFDRIRIGVFYANVFSVTWGLGMALILYLLNDPIASIFTDNPEVIRSTKMYLTIVSFSFGFQGIVQVVNSNINTLSKPLAASLIVFVQMLIICIPLLYLLEYSFGVAGIYSAVAITYVTGGLISAFFNRRIVAQMQTDYAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW58</accession>
    <name>A0A654DW58_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1146"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="8">
        <location>
            <begin position="227"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1180" mass="133158" checksum="F7C7B05CF775DFE2" modified="2020-04-22" version="1">MKEWMNWPWTEMLLACTVVHGIIAGVLLLFNKFPASQFLARLLLSTLIFLSSSFAPSGLFLDQFALALVAISLFLYTRSFFTQKTRNNNKHLLPLVLPALFTSASVMGVDFEYGFIIREGTLIAIVVIYLLSALRTAQREAVQRGIYWFQNPGSRLLWFRNFLLFSVLLITYWLLAGNTLSVWETSLGILIFSYFIYFQVFKESNFLSPIPLGNKYQKSTLTPGQKAAILERLDDLLQKDKFYLQSTISLSQLSDQLHTTTHHLSQVINETKSTSFQELISQYRVREAKHLLKAPEQQQTKIENIAAMVGYNSKSAFNTAFKKYTGLTPSEFKDTKGVRSYREERLPGQKKPFFQYLGLSSYHVLPNLKTNMVSNFLKIFYRRMVRNKVFSAINLFGLTVGFSCSILIYLFITDQLSYDKELEDSERIYRIAWMSDNPQTRTPHPMAQAMARDLPEVEAATSLSPWNGVGQSNETVKVENVEAEILFQEPNFFFVDSTFLDVFQLEVVAGDKDALRKPWNLVITDKMAKKYFGNEDPIGRELNVNDMPVEIAAVIKGMPDKSHFHIQGLVSYVTIKNINPSNPWFTWEDFGHFNYIKTKSGVDPAKLEAKIPEWVLSYLNWPQSYRASLLEGDYQFALQPIEEIHLSSHLRWELENNGNILYVYILTGTLIFLLLIVCINYINLTTAKSLERAREVGIKKTLGAYSGNLTLQFYLESLIFCLLAWILALLLAVLCLDTFNYLSGQAFELSDIFNSSFLLKSMGLCLALALLAGFYPAFTLSSFIPMEVLKGKFSSSFQGRQVRNGLVVFQFCISSILIISSLIIVKQINFMKNTSLGFDHEAVISIRVHPSVEIGGIDLRQVETFKEQFGNIPGVLNTGSISNLPGGQFNQNAIFLEDSPENRVDASELYVDYGTAPSLGLSMAMGRYFDPTYAADSAGTTFIINESAMSALRLEDPIGKSLTWDSDPVAQKGTIVGVVKDFHYQSLHEAIQPLIIQLNPEYANHLLVKMEGKNFQQTLNDIQISYQNIESELPFSYRFLDEQLANLYLSEERTLNVFSIFAGLALFLACLGLLGLALALLNQKAKEVSIRKIMGATPNHILAMVFSQFARLLGLALLLGLPTGYFLMQRWIGEFSYQVTLGVTPFLLASALLLLVALGSVSLVVLKISRANPADNLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB1</accession>
    <name>A0A654DWB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815948" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22537" checksum="DF2CD583ABDD9545" modified="2020-04-22" version="1">MKNPHLCLSVLLVFSLVWPLQAQDFPVSIEAEYDRLTAKWLEVSDGLKTYDGLSEFCANPNYRNDIITVLEHLHHYDSLVLDLLLDPTANTSDISHHEYKRSLSDIQKLEGDFDMNTFISFLKTSCLTRRDLERDKEDLKKESGIYSYDGQLLMLETQLGKFLKHIDKKVVLVDEHVHKIHPDQIRPLRLLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWH6</accession>
    <name>A0A654DWH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="809" mass="91103" checksum="E4DA9739739697FD" modified="2020-04-22" version="1">MLRNYYITALRNLLKHKSYFILNMGGLAIGITSFIFISLYIINELSYDRFHSQHENTYRVQVRGQMMGQNLNMAVTASPMAQALLQDYPEVTKVTQVKESGAWFIGQGNKKFNEDGVLFADSSFFDVFDFPLIEGDPKTALVKPRSMVLTETFAKKYFGNEPALGKRITVEQDTIFYEVTGVMADVPDNSHIKFDMLGSRSTYKVWDNNHWVSHNEYTYIVLNENADHKAFEGKLDEVVKKYVGPQIAQYLGTTMEAWESAGNSFGYYLMPITDIHLRSNVEDELEVNSHISYIYIYTLIAFILLFIAIINFVNLATAQSAARSKEVGIRKVMGSDRQALIYQFIFESILIAIAATLIAALLVALLTGQFENLINKELAISLTSSYLSIFILLGLAIVIGVMAGFYPAFVLAGFRPAEVLKGRVKAGAKTGWLRNLLVVIQFTASIVIIIGTMVVYRQIDFMLNKNLGFDKEQTLVIRRPDVLRQNLETCKTELLKNPNILAVANATSLPGKDRYNNNAHMTEDSPDSPYLLMENSVSFGYAELMGLELVAGRLLSRQYASDSTAVVINETAARTLGYSVEEAVGKSFIDKDRDGTIRRMPIIGVVKDYNIQSLHRPIEPTMLRLMHGNWEGFMLVKVSNTQNIRETLAYMEETWFKYSYNKPFQYFFFDDDYADLYKSESTTGRVFLVFAGLSICIACLGLIGLITYTTSIRKKEIGIRKVLGAGTTTLVTLLSSEFVKLIVISTLISWPVAYFAINYWLQNFADRLTITPWVFVFSTLVVVVIGSLAISFQTIKASLSNPIDSLRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWJ0</accession>
    <name>A0A654DWJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="244" mass="27927" checksum="7823371E28F2F202" modified="2020-04-22" version="1">MKIDLRKYLEERDHMHRSLLRDGPVLTVSRAYGCEANRLVMLLIHRINKLGPGALKKHPWKYISKEVIDECAFDLGINPHDVDQRILAHSTDGINGLLAGFAHHYEVSDREIMSKVKEVIINYAKRGNVILVGRGGSMVTEGMDNVLRIRLEAPLKWRARVIAGKLGIGDEAAYDLVQHMDENRVRWMEHLTGRTYNEHMFDLVINVEKMSDKETLDVILQVMKHRGMIPSQPLEGKSQKFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWJ9</accession>
    <name>A0A654DWJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="310" mass="34355" checksum="4A9737B0DFCC71AF" modified="2020-04-22" version="1">MSMKKYIAGILFILSGVIASAQMRALTSTYPFNGLLINPAYAGSLNVFSVIAVHREQWINVEGAPVYQALTAHSSFNSNRIGVGLQATRDQVGITESVSVYGSYAYKIKMSFGILAMGLQGGFDSRASDFSKLSVFDEDDQLLSGTVNRFTPNFGTGLYFANPHMYVGFSVPYILENRTLVIDESDAVAADSRESRYYYATGGVILPLTESIKLSPSILLRGQEQNRFAYDITAMVIFDNIAYAGISYRNSNDITFIGQLILNENFRVGYAYDATTSEITTETSGSHEILVNYRIKLRNYKKDPQCPVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM9</accession>
    <name>A0A654DWM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="5822" checksum="A771B0BA76238A39" modified="2020-04-22" version="1">MDKGRNSAHKEDERYSIGLSGFGIVDRTETGKGKPGYEETEGNTRGSEIVQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX16</accession>
    <name>A0A654DX16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="182"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="42455" checksum="2782FF0D3E41D258" modified="2020-04-22" version="1">MQHNIIDEAKSLRKYLHQHPELSCFEENTSRHLIERLRSECTPDELIVFKHYGVAAIFKGGKPGKNVLIRGDFDALPIQEINDFAHKSVVEGVSHKCGHDGHASILYALARYLSLERPEKGDAILLFQPAEENGEGAKGIINDPLFDSLKPNYAVALHNLPGYDLHKVVWRSGTFTAAANSIIIKLTGKTSHAAEPEFGINPALAMAEITQLILDENQPDLDADDFRIATPIYTTMGDQAYGVSAGYGELHFTLRAWDNQVIRDHEEKCERIARQVASSHDLKIQISWTQSFFANFNNERVITAIKNAAVVGGFETEQRTTPFKWGEDFGIFTERFPGAMFGIGSGKDCPALHNPDYDFPDELIETGMIIFKEIISQLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX18</accession>
    <name>A0A654DX18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Histidine kinase sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024919602" evidence="2">
        <location>
            <begin position="20"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="539"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="635" mass="72789" checksum="AA0E391878CA4A08" modified="2020-04-22" version="1">MRFYLTCICLLIGSLALTSQELSDEVKSVYNFNSTDRFIHVWDSLEQSGHGVFQNPVGEWLAPAEYFYEQAKLNQDTLTLQKLDYPLAIVYHTLALYEKCIPLLVELLEQRELLSEKRYQYAILKLEEAYRRTGNLKEAIPLRKQRIEAGFDHSFWEIYAEADLFTEAIKDFKHSVEFPAQGWNRMVYFMDLASLYKENGDYDSAIYYYDKAYEDGQYIMARVEYDGKSPYTESNKHYWTAYSRGMIGQVLVAQGNYEPAIPLLIKDIEVSKTIHEVDNTLNKRLDLAECFIHLGDLPRAASYIDTVKNLLGNRGWLATKLRLLEVEAEYFYETEQYGNAAKYLKEFNKLNDSLNELSNRNNLIAMTTLLDSDQQRAILAEQKLEIEKSNSIKKVQNNQLNLLISGIVILVLVIVVLFLNYKQKLNSKLEAERKLEQKEIFLRELHHRIKNNLQITSGLLQLQADKSKDDFVNSALRESKGRIRSMALIHNLLIGDNSISSVSLKKYIEELVELVEAGLGQPKDTRVTTSIEDLEVSGELAVPLGLIINEILTNSYKYAFDSSPGEISIRFYKGEHGGETLEIRDNGKGFPEHFSIEKSNSLGMQLITMLCGQIRAKLNIFSDHGAVYVIQLNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX41</accession>
    <name>A0A654DX41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="29609" checksum="6528B0F81B78824E" modified="2020-04-22" version="1">MSNTVSIYNFKGGVGKTTTALNLGISWSRSFKVLLIDFDPQCNLTNAITIEEPRNTIYNNIRNLLHDHDPDIEPLEITPYLHIIPGDFQMTQIESNNQFISFGTGIIARLLSSQRREYDFIIMDCPTNFGVLVKAILGSSKNILIPAQADSFSITGIQTLMGYLNMVENSLLNILGVFFNMYNNNLILSQEKFNEAKNSFGNLILDTTVSRSIKVGEALDIGQAISDYSPDNTAAVEFMKLSDELLAKFLGNVSSHVVLENLNLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX82</accession>
    <name>A0A654DX82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="12"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="249" mass="28569" checksum="66288AE23A302DA4" modified="2020-04-22" version="1">MSPFRAKKNTAAFVLVFSCALTYSQSSLEMGNRILGGGISINFSETESNNPENVIGSFYGDEYSNQSSNFFISPYYARFFKDYVMVGIDMELGSANHSQQSQYYNRNYENNSSSVSFGFGTFLKYYFPIHGDFGAYVQPGMGYLRTIQKNSYHHYDTLGGESYARGRNEIRTNAIHMDMKMGLYYFIFDQLSIETNLAQVVMSASQGKRREEDQQNGEISEGEERGSRLNLRWANKISFDQLFTLNYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF9</accession>
    <name>A0A654DXF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hybrid sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="845"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1349" mass="154602" checksum="4AE52EACA53CA3CA" modified="2020-04-22" version="1">MRNIKLLLVLFWLVFTQVSFGQFSQIRFEKLDTRDGLSHNRVTSIYKDQLGFMWFGTRSGLNRYDGNSIKVIEHEDDNSFSLSDQNIVWIKEGPEGYLWIKSDYGVFAYDIYKESYVDIRPLLAELDINHYNLSVMVKDGLGNFWFVIDNIGVKKYLSDTKEIYHYGGAYRDVSSVQPDNKGNMALVHLDGEIELADVSDLRNSSFMRYPEHIANIQGLTVFIDKDGDYWFYSSAYSFGVCYYRPSVGTCIHLDNKDLGSNLVTGIIQDESERIIIGADHGGLTMISKADWKLQSFSNNPSDPRSLSHNSIIALYQDRTGLVWIGTNKGGVNYFSPKSVSFNFYKQTDNQTPNANDIWPLVEDDEGNLWIGTDGGGLVHFDLRKGEFTNYRHKENDPKSISSDIVVSMAPGANGGLWLGTYFGGLNYFDGKKFKAYYHNPEDSNSISDNSIWNLLLDSRGLIWVGTLKGGVDVYDADFNKIHHFGLDNQGIHSNYVTSLCEDKDGNIWIGTGYGIEAYNYADGTMTHLLKEEGNDRSLVNNSILDIYCDHENSIWVGTMYGLSRFNRATNDFDSFVKEDGLPENIVTSVMEDLDGNIWLGTYTGLSKLHFENEAPIFENFDISDGLQGDMFNERSALRLKNGHLAFGGKNGLNVFDPEAIKVTNEENKLVFLDFYLSNRLIKPGDEYNGRKWFERGINNVEKLVLEPSENSFTLEFTSLNFYQQENTVYKYRLVGFDQDWIQRANVHRANYTNLDPGNYRFEVMASDRTHQWSDEPIAIDIVILTPFWKTPLANLIYVLFVLLVLFLTRRAIIQKERFRAKVTQDQMEATRLHELDMMKIKFFTNISHEFRTPLTLILTPIERMLKKSTDPQDQKHFQLIFRNAKRLLTLVNQLLDFRKMEANQHRISLATGDVIDFTNSIVESFSDLSADRRVRLDFESNLSEFLTLFDRDKMEKIMFNLLSNAFKFTHTGGRVVVKVSDIAYREDIHTIRFSVTDDGIGIPKERQGDIFNRFFQVDNKHTANLNHGSGIGLSITKEFVEMHGGNIWVESEMEKGSSFIFELPMKKLSGDYKVQDVVDDFMEESVPLPHEASKATILLADDNDDFRFYLKDNLERLYNIYEAPNGKAAWKKILNFQPDLVVSDIMMPEINGIELCKKIKGDPRTGHIPVILLTAHYSDDQKLEGFEAGAIEYITKPFNFEILVQSIRSAVQLQKLIFASEHRIEAKPREIEITSLDEQFIMKAMELVEVNISNSDFSVQELSRELAVSRGQLYKKTLELTGKTPIEFIRSIRIKRAAALLERSQLNVAEVAYKVGFNNPKYFTKYFKMEYKMLPSKYAAQATAQKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG6</accession>
    <name>A0A654DXG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="5357" checksum="0C84FBF13441162F" modified="2020-04-22" version="1">MSPYLFYHITIHYISYTFPNTFFMARFRVNMTLNLTLYFIPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK3</accession>
    <name>A0A654DXK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024793417" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="26607" checksum="96EAF7393F54395B" modified="2020-04-22" version="1">MRILLIVLLQFTLCALANAQELHIIMSKKAFLYDIRIKKRDVLRYSDKVLIKRHGFLTVSGASSKPMKLDEGMYEIGVEYQKHLERYQEHDRILNQLKSLGLEDCQFPYEIVPVSHNAHKLSGRIEIEKDSTVSETYNNTFSVVNTNERKSVQVNWTNPDEKYQEKYYILVEDLFGDFYELIETDEDNFHFDLSNYISESIPILFFTIIAEDCRESYPTAVRLRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP0</accession>
    <name>A0A654DXP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024930694" evidence="2">
        <location>
            <begin position="24"/>
            <end position="3129"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="241"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="336"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="3129" mass="342968" checksum="2CA875CDC9BDBDF5" modified="2020-04-22" version="1">MLYKVNKIYLFLASMGCVLFSHAQICPQNNANVDLGTPSLTTSAHTINTGDVESITVVKGAVYLFDKSSTSFSSHMALYSSLGGSIYQEKWKQTGNTKSWQSDYDGELWFTITDQNVGNSPTGYAYSCGYNATSAVLNVRQTTNNINITEHPTNVKANCGDPAIFSTNANISGTSNATFQYQWQVSTNNGSSFSNMAGATSATLNIAEVESTMFGNQYRCVIKVGAESANTNAGILLERGIDPPSGIEATQDRCDAQIDITWEWYQVNPSKFKIQVSTNNSTFTDLVELAGAKRKYQHTGITKGTRYYYKISSYNEDCGTYGSSSDSEYGLSPVDPAAPTGSSVQEVSVDGGKGVRVTWTDNSADETGFIITRTNSDGTNLVEYKYVSNETEMNQTGAVRTYTDKRIDNCQPYTYRVYAYNPCNATGVIAVDGSGSAASHDIVVETTIYDILYPSALVTSKGYYSDRISLKWGINMNSNHSFADRFKIYSRELGDAVVPELVSIVDSDLRQFNDDRADAGVLYEYFIVATGDCGDGEIKSFDITTINSYPNLPADLSGRGVGYSIGFRSPSGVVNGNISYQGGVAVPNVKVVVEREEGNSGSALDFDGVNDYMEVPYTTFLNFEGAITVSMWLKPDQVAVSDRTILHKNGTIKLTQSGEALKVDIGTVNVTVDTVFEANQFKNVTVTFDEAELIVYVNGKEYYKGSHSYDLTANTNNVFIGTNATKTNYFSGIIDETRLHTVSQDSLTILKDYGRLIKPNKAGLAAYWRFNEGVGPYAFDLSNTGGVYHVNDGNISGATWSVDVPDGRQLGMAGFTDANGNYTVTGISYSGTGENFTVTPKITLGGAVHEFTPSQKVLFIGEGVSVQNQIDFKDISSFQVTGYVRYQFGDNTVGAEGVRFLIDGETYVQNGSGFVESDVNGYFNIQVPIGLHSIQAQKAFHTFNNEGNWPTSTAKYDFQAPVSNVLIYDLTTRKVRGRVVGGKVEGEKPVGFGKSVNNIGASLFKLEEATGKPIEATVTPDANTGEYEVDVPPLKYTVYNPNKSDGSGLQRGIHIASNNSATLYFEQAILAEDLTIDLRAADTEKYVIDSTLNGSDEWVVDSAAYHSINNFIYRSEPQVGVYDGSEEVDQEFEGEEFYVHTNKDNTKDTIDVRAGMPYPVLIQSKDYSLRIEVSEIYERNDLGPVVKDTVPVSDAALELFNYWGKGYYRDSDDDVAYYSPVSASPGTLEAITLSDADGDTTYTFKTANPEFNNNASFDSQSFTKSIQVTVKTKGNEPVYWPGGSDVNIVQNGYILGSAPIAGTSFVTQGPDVVDFVLRDPPGDGSFTMLEQGKSVSKTSSFTSSAGQSVNLELGIGVSVTTWVGFGAGTINESEADATTGLDVSYKLSNTGERVTTYTATEAFQTSEDYTGPDFDLFVGKSENVRFGVSQTLSLVPVSDCGTPNVSCTGSVITAKDGTEYKLGSYLATFMNPTGEATLFAYTALHIEGTLVPNLKMLRNNVLLNNSKYVSALDGADPNFGKNNDDPVFPNPSTATPSITEPEDLSGPSYTFTRVDDEELDSVRWLNQQIKLWEKQLELNEKEKVELVQANRPVRNISYSGGSALTFEQTSSETSTTSFEYEFAESISAGTSLDFSLFGVSMELDMKTSVNLEQGGVESDSEENSTTFSYTISDESPTDYFNVKVHESTLKNGPVFQIADGGVTTCPHEDEVKTKYYQPGTQISARTFQQDKPRIEVDVPIMYNVPADEKANYTLTLFNDSENTQTMYYSLSVVESSNPNGLKITMDGTNLSKGREILVPGGSAIQKILEIEKGPFEYDYPNVQVILSSSCQYDPTGVYKLIGDTVSISAYFLPQCTTPEILTPKDNWVVNSNLMDTLTVMIGGFNINYSGFRSVNLEYKQSAQSTWSVLETFYRDTTGLNDPNAIQIPRNNPVIEYDWFLKDINDGSYDLRAVTKCDVAASGSVVFGESEIFSGLIDRVNPHPFGAPQPSDGILSPGEQIMIQFNEPINSGLLRPTNFEIKGVLNGGEVRHSASMHFAGDANHYMEIPAGIDLKRKSFTVDFYLARKSLGEQIILSQGNASSDALEIGFTANDKVYFKLANKIEVSTASITDQNWRHYALVYDHKNGTASITLNGDTDGDDINNDFGADYTDEGKVYVAQAKYDKTKPLDAKVHELRIWNRALSESKVSIIATKRLERNEFGLIGNWRMEEAEGSQANDHIRFKNALISGNWSIEPIGFAYDLGADSYLTSKSLAFTAENDFTIEFWFKRAATTDSVTLLSTGIGDARDANSVGWAIGTDASGKLLISNNGEKHQVGSVSYMDNTWHHFALSVNRITSPNVYIDGAQIASIDDQNWIGFGGSKVWIGARGWFDGAVEQTDQYFEGAFDDIRVWSKAKTAEQVELQRMYKLSGAEGSLVTYFPFETFVDDSGVLVKSVSLDNEVAGAKVDDVIALQGTGGEVENTPTINLPRPVSYVNFSYSANGDKIILSPTDPDSLLEGVILDITVKNIRDLNGNVMNSPASWTAYYNKNSVLWVDNDKSFDLELGSTLTFKASVSNIGGSVENFRITNVPDWLTVSPSSGTLSPLTTKEITLSVDEGINLGDYSQDIYLTTDYGYDERLMVNLNVYQPAPDTWEVDPAEYEYSMSLVGKVKVNGKFSQDGDDQVAAFVDNVCRGVATLRYVEAYDQYFVFLNIYSNRVSNENVELRIWDASDGIVYTKVDPAVAFVSETRLGSASSPVVIETTGLVQVRQDLVRGWQWLSFNTNSAQMANVNNFLANITASTGDMVKTQGAFDQYDEANGWIGTISNSGGIRNNTMYKFKLANASVLEFSGAEINPESEVIQVKEGWNWISYISQRTLEINTALSNYTASVGDEIKSQRGFAVYEGPMIGWIGSLTHLTKGNGFMLKSSTQTTFTYPSVPLTARLAPEPVSESDMHSVGMSFDQYPSNMSIVATANMNFDEGNQMMVYDETELVGYAYPKYIGQQQLLFITVFGEQPSGALSFEDSFGRLYAPEDGRTLEFRADASHGTVGSPLRLMTNTTEVLDVINSTVRLYPNPFQESILLEITSDTKDLSYELVDLSGRLLQKGNIPTHQKSIRFGETLESGAYFLKIYRAEELVKTEKIVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP8</accession>
    <name>A0A654DXP8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="13" type="ORF">MARINOS108_11490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="15"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="630"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="827"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="550"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="893" mass="102449" checksum="1C1B12A85D1AF359" modified="2020-04-22" version="1">MEISTKYDPAQTEDKWYSHWMEKGFFKAKVNPEKEPYSIVIPPPNVTGVLHMGHMLNNTIQDVLIRKARMEGKEACWVPGTDHASIATEAKVVAMLREKGIKKSDLSRDEFLKYAWEWKEKYGGIILEQLKKLGASCDWDRTSFTMDEGYYKAVISVFNDLYKKGFIYRGLRMINWDCEAKTALSNEEVIYKEGGEHATLYYVKYKIAGSDDFVTIATVRPETILGDAAIAVNPKDERHAHLIGQKAIVPFVNREIPIIGDDYVELDFGTGCLKVTPAHDPNDYEIGQRHGLEVIDTINLDGTLNENCGIDKFVGVDRFVVRKQIVKDLKAAEFLLKEEDFVTRIGRSERTNTVVEPKLSLQWFIKMKEISRTAHKVVMEDEILLYPPKFKNTYNHWMENVRDWCISRQLWWGQRIPAYYYDEGEEDYVVAESLEEAVILACEKSGKQLTASDLKQDEDVLDTWASSWLFPLAVFDGFNENCFDKETGKVINGKNAELDYFYPTDTLVTAPEILFFWVARMIIAGYEYKGDKPFKNVYLTGIVRDKQRRKMSKSLGNSPDPLDLIKQYGADGVRTGMLFSSPAGNDLLFDEKLVEQGRNFSNKLWNAFRLVKGWNTVDQPQSEENALAAKWFESRFYAAKEELEDHFSKYRLSDALMTAYKLVWNDFCSWYLEWIKPGFEQPIDQKTYDQTIAFFELVVKTLHPFMPFITEEIWHTIQERDENDCLIKAAWPESKPFDKSVLTSGDLLFEITTNIRNLRNSKGLSPKEELALMVNTSDHALFEQISASVQKMANVSSLDFTEEKPDNCFSFVVQSHELFVPVTEQIDVEAERKKLTEELGYTIGFKNSVEKKLSNERFVSGAPEQVVAMEKKKLADAEAKIASLEASIASLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ0</accession>
    <name>A0A654DXQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28653" checksum="8FBE93F93C182C28" modified="2020-04-22" version="1">MLSTKSQPEFEEVVVGTKSYTFENGIDELMFMPDNYVEVLYNLGAPITRKLIGSIRSVVINTGDLVLSTCRSKGMSLSSESLNFLCAKVRPEYTMLLYPKDVPLERDAVITLGMPRLENLAQFESHLDHLLEGINDFEPSFIVEEAVRIIQSTNGEVKIKDINEQLSVSKSFLEQRFAQEIGLSPKEFGKIEKMKHFLENYRQYQDSMTLTQLTFKSGYYDQSHLIKDFRYFMDSKPRDFIKAYHHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY14</accession>
    <name>A0A654DY14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13781" checksum="C204AD727FFC4105" modified="2020-04-22" version="1">MSNTCIRVLADPVQIKECKETLSRLEEQLDLTTKIFNLAGNAARLKILFLLHKEGEMCPCDLSDILDISVGGVSQHLRKLKDGGLVKDKKVGQTVFYSLVEANLEIIKPVLESLSIQNQKELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY27</accession>
    <name>A0A654DY27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="646" mass="72691" checksum="040884FBAE6D0737" modified="2020-04-22" version="1">MKFPYFITLLCSAFLLVQCSQEPSEKEKALDIGEYLSLVQGDTIHPNARQLALLKEVVPQEAYQPAPAYTDRSYWVAFGSTDLGKYYLKEADELIDRSPEVPISDEIYRRANKEGNRGIYKPRYYRTMDRLEKYILAECMLNDGRYLKPIEEHIRAIMAMKSWLHPNHDDDENTVLEGKRVHIDLGARKFGLVLALADAVLEDKLSDELRVEINGQLRWRITDSYLQSTKELKPKSNNWIRSTSNWNSVCTSGSLFTIIVSSDDYDERVQAIGSAINSMKYYLSGFGEDGYCSEGTGYWSYGFGHYLYLAEILHDYTDGKINLFEFNDPEKLRRVANFPEVFQIHPGLYSPFSDGVTRVKKESDNFAYLMATKYYGAQKSSYFKPDEAVKSIVLGADYKKYISEEPLPVALPSVTYFEDYGVVISRGQQEVPFSISIKAGHNNENHNHMDVGSYIIAYGEEILAGDIGAPSYIAGAFSDDNPARSSWGHPVPRIDGTLQSKGREFKGKVLEANFTDEKDQVVMDLLTAYEIPYLNTLIRTVQNDKSGVGKITVTDQFSAGKPVTFGTAIMTLADYEVVGEKTVILTENGMKVKAEVSSSDGELQILDELVPVEHLREGAPAYRIGVDFKDSITKGTITVTYSPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY31</accession>
    <name>A0A654DY31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="29689" checksum="0BA770E7A421786A" modified="2020-04-22" version="1">MKLQDQLALNKKEGKALLATNFYNFETLSAVLTAAKETNSALILQLSESSLHYMGLEVAAQMAKSAISQYGVQAWLHMDHGGDVNLVKACLDAGFDSVMIDASEKPFAENVKITQEIVRYAEQFGANVEAELGYIAKLGQGQDMIYTQPDEARRFVEETGINALAVAVGSAHGFYKETPKLQLDLIAEINAATSAALVLHGSSGIPHDQVQESIRRGITKINLATEIKNIFMKKLQEVLADSDEIDLRKVFPKATQAATDLVSEKLKVINFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY52</accession>
    <name>A0A654DY52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006946">
        <property type="entry name" value="DUF642"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04862">
        <property type="entry name" value="DUF642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024988909" description="PKD domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="302" mass="32568" checksum="CA4AA6B1A69C3286" modified="2020-04-22" version="1">MKRTFLSGKKATAFFSRGLAATILAFGALTFATSCGEDEKVDPPVPAAASFVAQVDVFEVTFVNSSTGAVSSAWDFGDGNTSTELNVVHTYTSPGDYTVTLTVTGEAEDTDTAEEVVSIVIPESSFENGDFDLYPADHEMYQANNDMWEPPTADDGWTGREGFRAGGMTTDGKKLEDGTKTNGLKIYGPERGAYQVVDVVPGATYVVTFEAATEVIDEPAVDLVSAYILSEEIKTEAAITEANTMAKVTVTSYPTAAKGEFQTYSMEFTATTDKVLFFLISDDPLVDGTREVWTDNYVIDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY81</accession>
    <name>A0A654DY81_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="1">
        <location>
            <begin position="33"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="22190" checksum="F133322486F365E9" modified="2020-04-22" version="1">MSNRISSPDKSSLFLLLFSFLFSCHPKVVDFVNTKSNFNAFDSYLVVNFKANQTDISEEGRKILSEIEQNIHLEMNRRAYRPINTNPDLVVRYELISNQAIKTQQNNYGYSPYSTFPSQSYITVKAVLESALLIEITDVKTKKLVWQASVDMDKYTKKSKQEEIIKDAVTNLFDTYLYRANSNTPDESLISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF2</accession>
    <name>A0A654DYF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="35582" checksum="13D429608E9D2BBA" modified="2020-04-22" version="1">MKVLITGANGFLGSHLVEKALKKGFETSILIRPGANLSNLEHLHGYHVVEVSYDSVDSIAAAFKDLPAQDLIIHNAGLIQSYTLDRYVKVNVDLTRRLIDAIRQCDILTPSGRLAYISSLAAKGPVGNGGPASNYGRSKLMAEEVVKNSGIKYMIYRPTGIYGARDVQFVPLIKAVKLGLYPSMTPKAHKMTLINASDVAENVLECSLKYENQTVHLEDGHVYQHEDLKQALEKLLHKRSINLRVGRPVVKALLAISDVIDRNLNRTPTLSREHYSEISQDWDYDFSKERNEIPLTIQYSLEDGFKSAIDYYLEKDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG4</accession>
    <name>A0A654DYG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sialate O-acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="PTHR22901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="106"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="399"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="631" mass="71106" checksum="05DF7FC36FB5BE50" modified="2020-04-22" version="1">MIRLFRPLTIVIFMLVMPSWAEAQLVLPQVFGDHMVLQRDQNVRFWGWAAPNEQISVEVDGFAVTTKTSPEGKWEVLYPSHVAGGPYTVAVKASTRIELTDVWFGDVWVAGGQSNMEWKLGGKINNWEAEIADSDYPQIRFFDVPRELALSPQDNISGGEWRVAGPKTAADISAVGWFFAKSNHLEKGVPVGLIQSNWGGTPAEAWTSAERLLEVPGYEKTAAEMLDATIDWEALKKANDDREKLKWELIGDETSFMSLGAHLVEYDDSAWKTVSLPNKEPIMDFVWVRKHVNLKSAKGVRLYMGEITQLCSVFMNGQLVSKESWQDSTGIVEISPDIARKGDNVIAIRASNSWDNRVWIGRSGEMWLEASGKKQSLEGEWKYSNTLEPAMPKVERFNWKPGVLYNGMIQPIAGYGIRGAIWYQGESNADKPHLYNELFEAMIEDWRIRWRQGNFPFLFVQLANFMERKDLPQESQWAELREAQTQALQLPNTGMATIIDIGEANDIHPRNKQDVGRRLWAAARKVVFNEEVVFSGPSFSSQEIQGDRIILSFDQVGSGLMTTSGDPVGFAIAGADKQFVWAEAKIEGDQVVVWNDQIANPEYVRYAWADNPACNLYNKEGLPAVPFRTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ6</accession>
    <name>A0A654DYJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane starch-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024932421" evidence="5">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="321"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="581" mass="64807" checksum="223FA1B687B230C2" modified="2020-04-22" version="1">MKNIFLSFLVLGTMMMSCQDAFTDLEPLDEITDATFYSTPAHFELASNHLYDGMLGWGADGEFRDYGSDLVSIPQIYTQGNVVVPETDALWNEGYDDLRDVNMLIESAAEYTGDASEIAPYVGTAHFFRAYEYFTLLQRFGGVPLITTVISSASPDEVFETPRSSRYEVIGLILSDLDEAIANCPPSVGESDLGKITSMAAKAYKAKVLLYEATWEKYVGTDTDGDGSTTGAGSSKPANYPTVEAMLADAIDLSKDVMVNGGYELWNHDFPEINSNFFLHQLEDGGSNPLGLDKSTNKEFIIQKVYDYNLGFGDLNFATTESRMAPNRKSMDMFLCTDGLPISKSPRFQGYNTMWDELQNRDNRMVAYFYNVPENGSPVLNVGPSDSGAGIGIRNRKFRSWNGYRPNERQAQNYSILRLAEVYLTYAEAIYELRGSITDAELDESINLTRARAGIDPLSNNLATTYDLDILEEIRRERALELYCENTRIHDLKRWGIADEVFAEEIYGAVIEGTVYDGDESLYLPSIYPFGEKTITVGNGEDRRVVVRDGASNRRFTMAHYLAPIPISQISLTGILQNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ9</accession>
    <name>A0A654DYQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="14724" checksum="61EBF55BFFAE513B" modified="2020-04-22" version="1">MFLITFILYVLNTNPVTSYQIHSIGYANLVEGCVSKDKFMNSNFKTRYINDKDSVKYIVKFLSQVKCQKKRNPAKRDNIRMVIVDSNYDSIFYHWDTTFEINEIHYKGRRGTLDFLDSIDPKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU0</accession>
    <name>A0A654DYU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032342">
        <property type="entry name" value="DUF4861"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16153">
        <property type="entry name" value="DUF4861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="414" mass="46178" checksum="37B9F7210802E595" modified="2020-04-22" version="1">MTTKVNNQPEIGKMKWMVLASLLYAALFGCTADSSPVIRLINQDNVEKTGAIVYLDKNDIGLIQGNLRITSSNYEIPAQQIDTDGDGDWDQVLLLCDFEPKEVKALEIAADKADNQISAEPYTNISFSVKAQDRFAGSKITEIVRKRGATQRISDPFFQLEGPGIENDKVAFRTFFDPRNGKDIYGKTTDQMILDRAGIGSSWHQLSDWGMDILRVGQSLGAGGLGVIEEGTLYRLGDADEITYQELYSGDLESSHRLEFKGWDSGSRKIDGSERLTLTKGKYYYRNDIGISDTTLTLAVGIPSFKSDSVTFRKHNDLFSSISTYENQADGTDSKLGLAVLFSSDQYVDHGSTDTTGTVSDTHYVALKGQPETRIYFFACWELSDVYFSKRSNFEEYLQKEADKLSNTIQIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB3</accession>
    <name>A0A654DZB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_12061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="206"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="625" mass="71625" checksum="4711A0B81DB1B651" modified="2020-04-22" version="1">MKQYWGFEAFRPMQAEIIGAVLDSQHVLALLPTGGGKSLCFQVPALCFEGVCVVVSPLIALMKDQVEQLKKRGIKAAAIYSGMSLKEIDIVLDNCIYGAIKFIYVSPERIKTDLFLARAAQMNISLLAIDEAHCISQWGYDFRPSYLEIADFIETLKITRIIALTASATAQVRLDILEKLGMNEPRVFQKSFARSNLSYSVFELENKEQKMLEILRNVPGSSVVYVRSRKQTRELAEFLRNSGVSADYYHAGIPGHVRARRQDQWISGQTRVIVATNAFGMGIDKPDVRTVIHYDLPDSLEAYYQEAGRAGRDERKAYAIQLYAKNDVINLRRRAEQAAVSVDFMRKVYQALANHFKLAVGSSAFTSFEFDYEGFIRTFDLPMVETYHALNKLADEGLIELNESFKESSKMIFLLEQSEVYKYQVANRTMDPVIKTLMRLYGGEMFSDFVTIKEEDLAKLLKEPVDLVRNQLQYLHQAEVLIYQQASDKPRINFLTPRVEANNLPIDQKQMAWRKEVTLTKAKKVEEYVTSEHKCRSRMLQSYFDELTYQDCGACDICIHRHKKIQSMPLDEIEAFIRENPKKESELIQQFSRLALDDLVTSLRVLMDQKRIGLTKEELFEVKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG6</accession>
    <name>A0A654DZG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7277" checksum="E2323C5E9026C7F1" modified="2020-04-22" version="1">MITFTNQPQTASFQAEFDAEEQMLIASCVSKIKKHLDRNLELAKSPSQVSRLLTAKWYINQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS3</accession>
    <name>A0A654DZS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="4600" checksum="18A72243FF3F8A8B" modified="2020-04-22" version="1">MVKMSDASTELSMTFSIDVALGIVTLSPALLSDLGIITLSSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E008</accession>
    <name>A0A654E008_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="2">4.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="282" mass="30973" checksum="5E4CA1029F4B79F0" modified="2020-04-22" version="1">MKLIRFGAFGSEKPGIEIDGVRYDVSNIVRDYDEDFFADGGLEKLKATFDASKAAVVSNDVRLGAPVRRPGKIICIGLNYRKHAEESGMTVPTEPVVFFKATSSVIGPNDTIVIPKNSKKTDWEVELAVVIGKRANYVSEAEALDYVAGYVLHNDVSEREFQLERGGQWVKGKSCDTFAPLGPYLVTRDEVANPNKLNLWLKLNGKKVQDGNTDDFIFNVQEVISYLSQYMSLMPGDIISTGTPEGVGLGFKPPVYLKEGDVIELGIEGLGQARQEVVAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E034</accession>
    <name>A0A654E034_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">engB</name>
        <name evidence="10" type="ORF">MARINOS108_120316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="22495" checksum="D766234BB6F92256" modified="2020-04-22" version="1">MKPIKSAEFIKSSAEVGECPAGDKPEYAFIGRSNVGKSSLINLLTNHSKLAKVSSKPGKTQLINHFLIDDSWYLVDLPGYGWAKVSKSQKASWKKMIAGYFETRENLTNVFVLIDSRLEPQRIDLEFVTSLGQAGMPITLIFTKVDKRGANKAQSNIAAFRKILKKEWEELPLHFMTSTVTGQGKDDIIGYIREINEGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E5</accession>
    <name>A0A654E0E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22919" checksum="BD6C26CC3427FD4B" modified="2020-04-22" version="1">MTQETAEYKIKEAAKDVFMIKGMAGARMQEIADKAGINKALLHYYYRSKELLFKAVFEGIIKAFIPKMLQLFTSDLPLEAKVYQMADKYVDFLSEHREMPLFILTELRRGPLKLIQALNIGGLIDLSVIQRQIDEEVAKGNIRPITAPQFMLNFVSMMVFPFAAGHMFTGIFGVSEEEFQKIMEARRTEVPKFIMNALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H8</accession>
    <name>A0A654E0H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4789" checksum="46BCA8E5CCDFD5FE" modified="2020-04-22" version="1">MKIQLTPEYLKLVSAAADRVGLTVNEYIAKVIIEHFERRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P5</accession>
    <name>A0A654E0P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="6">
        <location>
            <begin position="890"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112249" checksum="697A059A54E19831" modified="2020-04-22" version="1">MNKHKPNFTEFNKTSYADWHAEATKLLKGKDPDDALKWHSESDLPLNAYYDPSTSDHLKYLRTFNLHNINGRKTWTQFEQIEVVTEKEANSQAKTALLSGCEGVLFEITSLPDLNLLLEGIHTDHCYIGFINHSQEILPVNVSGIKGFGQRVKCEAPAFKNHLLIGTNEDHTIIGSSVSLLRSVLKELSGANTREYLQNLQVAVNIGPDFFHEIARIRALKLLIQACAETLGVKNYALPIHAFPLPGQNEGDHLLKQTTQGLAAIIAGADSISFHQGKPEWAAGASHRISRNIGNLIRHESKLEEIQSAANGSYFIDHLTDRLARIIWEGVKEDFRNISFDELIQTQKKVVTEQPPEHIGFGAGVPPFLRGPYATMYAVRPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVSGDVGKAGVAIDTVEDMKILFDQIPLDEMSVSMTMNGAVIPIMAFYIVAAEEQGVEPAQLTGTIQNDILKEFMVRNTYIYPPAPSMRIIADIFRYTSQNMPRFNSISISGYHMHEAGATAGLELAFTLADGLEYIRKGLEAGIPIDSLAPRLSFFWGIGMNFFNEIAKMRAGRILWAKLVKQFDPKDPKSMALRTHSQTSGYSLTAQDPYNNVGRTAIEALAAAFGHTQSLHTNALDEAIALPTDYSAAIARETQKYLQNDINITQVVDPWGGSEVVEKLTDELIQEAWAIIQEVEEMGGMAKAIEEGFPKMKIEEAAARKQARIDAGQEVIVGVNRYTTEEKTVIDLLEVDNEAVRNSQIERLKSVKGKRDYQKVENALEALAMCAKTNQGNLLALAVDAARERATLGEISIAMEEVFGRYQATNQTISGVYSSEIKQNPDFLQARKLADQFDEAEGRRPRILVAKMGQDGHDRGAKVIATAFADLGFDVDIGPLFQTPQEVAKQAAENDVHMVGASSLAGGHKTLVPQLVEELRKIGRSDILVIAGGIIPENDHTYLRAHGVSFIFGPGTVIAKAASEILTELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S4</accession>
    <name>A0A654E0S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="433" mass="48615" checksum="98CCED5E72401515" modified="2020-04-22" version="1">MPKQDKTAVLAAVFIFFAGISATGLLIPRHHGWMLLFAYFSAFFAYFWLCKSEIKLHHLLAIGLAARLILFLGLPSLSDDLYRFIWDGTLLREGFSPYARLPAEYLTQGIQGVDQQLYDQLNSQPYYSVYPPLNQLFFWISASIGTSWLAQANVLRVVLLMADLGSVYFLYRLLQLHQKDLSVIGWFFLNPLLILEATGNIHFEGLVVFFLLLGLYAFEKNRMISSGIGLGLAAATKLLPLIFLPAIVIRKWFRDGATVGIVAGLVVSIGLIPFINSAILSGMQSSLGLYFQKFEFNASVYFLLREVGFWLKGYNIIGILGPALSGITILGIVGLALRGQRRKWPVHKTMLFSLSLYLLLATTVHPWYILPLIALGLLSGFYYPITWALMIFVTYFGYQEAGFELSAIWVVLEYGVVLSTFAIELIRSHEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X5</accession>
    <name>A0A654E0X5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA pseudouridine synthase C</fullName>
            <ecNumber evidence="2">5.4.99.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truC</name>
        <name evidence="2" type="ORF">MARINOS108_120270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.26" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="26555" checksum="61362B2D1EC4ADC1" modified="2020-04-22" version="1">MLEILYQDDHLVGINKPPGLLVHRSPIAKDAEEFAVQLLRDQLEMHVYPAHRLDRKTSGVLLFALEKDIHRALNLQFAEKTVSKTYYAIVRGFIPDAGTIDYPLKREDGKEQEAVTHFECVAKAELDVPFGKHATSRYSLVKVKPETGRMHQIRKHFAHILHPIIGDRPHGCNKQNKLFKEKWDLMEMMLHAHELTFIHPQSSLPVTIKAGFPDEFRRMMMLMEFEIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H0</accession>
    <name>A0A654E1H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021857">
        <property type="entry name" value="DUF3467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11950">
        <property type="entry name" value="DUF3467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12254" checksum="51D3898E8CF82480" modified="2020-04-22" version="1">MDPKDEKKGGNKPSNQINIELSEETAEGVYANLAMIAHSSSEFVIDFIRLMPGVPKAKVKSRIVITPEHAKRLLKALEDNINKFESSYGDIKSVEETPKFPMNFGGTMGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S2</accession>
    <name>A0A654E1S2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="27534" checksum="0FF82F5D39DBAEF6" modified="2020-04-22" version="1">MKNKIPEWLSNFPTIGFAFFAIAVLITITYFFMLATAGKRTKKFIFASAKETVYFDIATRFVAFGLVFFAFYAIINWIGKAAIYHIFGAGFFSIIIGVAFGYAFWAIVKYYYPFVLEKRLDKIRFKPMKSKAGNPMRLLNEEEEDEYMTPAMIEEEDNHIADYDIWVDEKTGEKVVEKYDMLFHALVCEKCNYRTMRDLREEVVKEASASEEGLIVKHYKCTYCGHSKTQDLKVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V9</accession>
    <name>A0A654E1V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024848539" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="538"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="618" mass="68888" checksum="5FABAF6AD2A2175B" modified="2020-04-22" version="1">MNMKRFLNIILFIGIGHFGFSQFANTAHVQSLGGGVATGGNFSTLAVSGDPSASSELALGGNQAVYSGFMPGKYIILSFGLEKDAAVLAALYETLGGADWVTNEGWLVSENIGEWAGVTITNQRVSALMLPSNNLQNEVPELIKNLAKLEHIDFSNNQIRKLPDLSGMPNLETLKVEENRLGFESLIKNKNIADYSYAPQKRYGFTKSDTVEAGQAYQLVATVPGKGNVYQWLFDDFPKPDEAVEVAGANKTSLMLTDIDYSNMGAYRLKVTNPALPDLEIETRNQNIWAATDIYGKVYADDQGNLLTDGQVEIYRIFDGPFTLSDSSVIDSEGNYVIEDVVLGDFILLVKNNPETFPNVLQTYYISNNDWIDADTLFLREQADDIDIDMIFKPQVTPVPTGANFDGELFSELDETIVDEEDGRIYARRKVKRAACSMRRFVRSGRGIEEDIYELYAYVESDDEGRFNFEGVEEGKYLLNIQYPGVPMDSNSDIEFVVGGDKENQRFSLVATITDQGIQVEANEVLYSLKPYLKDIRLYPNPTEGVLSIDFLVYRKLNDLKVEVVDVKGVKLMEQELSPKMGIQTARVDLTTYEAGVYFLIFTDEGGTFRQQVKVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X8</accession>
    <name>A0A654E1X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTTM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_140071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12639">
        <property type="entry name" value="PTHR12639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="445" mass="51172" checksum="FD0ED4F366AD1F71" modified="2020-04-22" version="1">MLALKALLAERLITGKVSIAPLVTFRILFGLLMLASIVRFWAYGWIHQFYIAPKVYFPFLPGVEPLPGVGMYVVFSAMAIAAAGIALGWFYRVSTTTFFVLFTYVELIDKTNYLNHYYFVSLMAFLLIWIPANGDFSLDVRRGTRRPTDQVPVGFLNLLRFQLVVVYFFAGLAKINSDWLLKAQPMKMWLSANAYRPILGTILRYKVTAYLFSWFGMVYDLSIPFFLSLKATRQLAFFCVVVFHLMTWWLFPIGMFPFIMIGLTTVFFSPEVHLKVLTILKSLFKWQVRPEVRPTAISHPLLKLFAVFIALQVLIPLRYLSYPGDVFWNEAGYRFSWRVMLMEKAGSATYYVRDRDTGQQSMVANYEHLSPQQEKMMATQPDILVQYAHYLHDHYEGLGMTDPIVTADVFVTLNGQPSRRFISPEVDLSKESIIGSYSLVVPLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E281</accession>
    <name>A0A654E281_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructan beta-fructosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="39"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="389"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="496" mass="55819" checksum="0C3CA68A8C3F5EA2" modified="2020-04-22" version="1">MKVTYLLIILFLATACQKRNESATPSLMKYDEKFRPQYHFTPPTQWMNDPNGMVFYEGEYHLFYQHYPDSNVWGPMHWGHAVSEDMVNWEHLPIALYPDTLGYIFSGSAVIDWKNTSGLGTADNPPMVAIYTYHDPVGAEAGRNDFQTQGIAFSLDKGRSWTKYEGNPVLANPGIIDFRDPKVSWDEANERWIMILAVLDHVNIYTSPDLIRWEFQSEFGHTIGGHGGVWECPDLFSLMDQYGDEKWVILLSINPGGPQGGSATQYFVGDFDGTVFTPADSVTRWIDYGADNYAGVTWADIPEIDGRRLFLGWMSNWQYANVVPTYEWRSAMTIPRELSLHKSETGYLLQSKPVPELETLMGEAIVSHESTMDLSAESYLVELTNVQGQSLDITFSNEQGERLVVKLTADRLVIDRTKSGDTSFSEDFAAIHEAPLGGVSVSDIQIYMDRSSAEVFVNYGAVVMTDLIFPTTPYTKVSVSASEVKLSLTPMASIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B2</accession>
    <name>A0A654E2B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound lytic murein transglycosylase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mltB</name>
        <name evidence="3" type="ORF">MARINOS108_120418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011757">
        <property type="entry name" value="Lytic_transglycosylase_MltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163:SF0">
        <property type="entry name" value="PTHR30163:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02282">
        <property type="entry name" value="MltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="37160" checksum="A9AA1BE68D33E554" modified="2020-04-22" version="1">MKMGVFKKTMGLVLLGLSMGLSGFGQVDQVKVAEFARSFSDRNEMSLEEVTVILNNARYQESIIRKMEKPAEGTMTWGRYRKIFMTEDRISAGVEFWKENKVVINDVSSKTGVAPEIIVGIIGVETFYGQRQGNYRVLDALYTLAFGFPKRSSFFTAELEKFLLLVKEENLNMYEIKGSYAGAMGFAQFMPSSYQAYAKSYDEGGSRNLMQADDAIASVANYLKEHRWKEGELVALPIKNMVNPTKLTPGVKPNNSLRFYSDNGYMPSGNLSPATMAALIELEQEDGMEYWFGFNNFYVITRYNHSELYAMAVFQLAEAINADYEAVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G3</accession>
    <name>A0A654E2G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="304" mass="34957" checksum="13E550750B26609F" modified="2020-04-22" version="1">MHANENPQGTLEMSELQYPENEIERFRSTLLPYAYNIIGTMEPARDVVEEVLVPFVLKKHPEVQNPTGYLVKSVINRSISHKNLLRSRLEHYPDHWLPEPVITEEGIYQGVDKERILSYSLLVLMEKLSPQERAVFILKNAFEFSHKDIGEVLGVEEEHSRQLYKRSKDKIHLKRGKKKALSSQDSDLLNELIGAMRSADLPRIKHLLKNKVESRSDGGPNNSAVRKVLRGKDHVSKLLRAIGTKYYLENTQVEVISVNHQPAIAYLQNDEVYRVMILEVEADKVTGVFVVINPEKLMDFRINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J6</accession>
    <name>A0A654E2J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine/succinyldiaminopimelate/putresc i ne aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="43017" checksum="95829E561A259B70" modified="2020-04-22" version="1">MISNRQLFLSHLAQTTDFPLLVEIERAEGIYMYSPEGKAYIDLISGIGVSNVGHCHPHVVKAAKDQIDKYMHLMVYGEYVQTPQVKLAEALVRTLPAPLTSVYLVNSGSEAIEGAMKLAKRFTGKPHIISCKDAYHGSSQGALSAGGNEFFKQNYRPLIPGHLHMPFNSLPALDLIDHQTAAVLVETVQGEAGVRIASPEYFAALRAKCTEVGALLILDEIQAGFGRTGKFWAFEHYNIVPDILVSAKGMGGGMPIGAFISSKEIMDVLKDNPILGHITTFGGHPVSAAASLATIETIMSENLLAEVEAKADYFRSLLVHPKIINIRNKGLMMAVELESFELLKPVIDKAIELGVVTDWFLFCDNSMRIAPPLIITFDEIKKACNIILQALDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J8</accession>
    <name>A0A654E2J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027013">
        <property type="entry name" value="Caskin-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF7">
        <property type="entry name" value="PTHR24174:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024850511" evidence="2">
        <location>
            <begin position="26"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="21256" checksum="B2AC1D84742106E0" modified="2020-04-22" version="1">MKSLTQKTVQKWMTLSLIMIFLGTAACNQTQEKASKETSVEAPSTTLQEATFFGNLDAIKGHIAAKTDLNEKDAYGSTPLHIAATFGKTEAALLLISGGADLNSTSADGSTPLHTAAFFGRTDIVKALLENKADVTIRNTYNATALESVSAPFADMKPVYDQMSKDLGPFGLKLDFKQLEKARPVIAEMIETYSNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K2</accession>
    <name>A0A654E2K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="221"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="361" mass="41326" checksum="AA84846AF92DA4FF" modified="2020-04-22" version="1">MRTHTSFQPDWTSAPGQTMKDMLFNKGMSIPEFASDLNKSVDFANGLLAGYEEINPDVAYQLQLILGASSKFWLNRESIYRSQIEKLSVSPEMWLSNLPIKDMIRLGWINRTSDIYQECLNFFNVRNVQVWSQTYISSIEASRFRRSNTHDSKLGSLISWLRYGEIKASSTKTGQWNSEVFTNRLDEIKQLSRVKSPKDFLPRLNEICAECGIALVVSPTPAGCPASGAVKFVKDDKAMMLLSFRYLSDDQFWFTFFHEAGHLIMNHGSKTFIEEINNSTEDEDEKEANLFAGEALIPSPLRNEMRYLRRDKHSIVRFAAKVGVSPGIVIGQMQFEGLISPAYLNGFKRRYNWNEISEFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P2</accession>
    <name>A0A654E2P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="709" mass="81605" checksum="A3D07415DE127362" modified="2020-04-22" version="1">MQKIKSAISFGAFCLLILISVSGFSQMTFQQSPLLEAKMFIDTMEYSWSRHTLIRNQKEMLAFQYDREDEIAEVYLFFDGDSEVADIALMPSADYYPLDSIMMFSDYARFKVRFNQLTTSEFLKFTLGIREDSVVKYVDMPLFPYTNTYVELYPGSEELYIGEEKVFELTSNNSENILVDNRWTEGLPINYRMTREGPKLLLHLLPNTLGDQQIVVPFTLRKPTMEAGRPKYQLKSLSYTFKIRSGRLAFLQFDAQEVTPKDDKKEAIEVQIDNNRFLRLGKTYRIEDQEESGGALIAELYTKARLNNDKVLCLLRPYSYHRKSDGYLYIKDGDDARFVSNLDITPKTTIQEIFIQREGKDWRRGTTVYPGETLNIKLEGEGLHKAAFSFPGASNLEYDSLIKNENISLFRIKVPLTINTNNIEIFNHNKSTGKSLKVEEYQRPRPFDFINLDFGDRQLVVSDIEKPIYYENTLTDLVFDFDRGKIDEGKDLFGKQYLTIKVKISNKKGNLIELYQFDEVVICPGETSPRFVHYDDKYCRSEDINLNNFLSKKTSELEEWSRIELEISHVKSKYGGDGRTKKIQIHLKRDYNFDIDVSFPAGLLILKSGTGNFGNFGGPSFAMIAQMSFYQPGRIAKYRPYKLGAGFIAIDAFNFTESNSRDVGLVVIGSLYPTSSDNKLTFPLYAGFGYLLSEQKPFFLIGPGIRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T7</accession>
    <name>A0A654E2T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="7238" checksum="9FE402596AD1A9D1" modified="2020-04-22" version="1">MFANWTFKDYCTFSAIFMWHTNMKRINFTLSIQKNLSHLIKWLNINDFNFFHIPPLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z6</accession>
    <name>A0A654E2Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">MARINOS108_20453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="60" mass="7072" checksum="AFA414E9B34F9E1A" modified="2020-04-22" version="1">MAKKGNRIQVILECTEHKTTGLPGTSRYITTKNRKNTPERVELKKYNPIMRKYTVHKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z8</accession>
    <name>A0A654E2Z8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21277" checksum="2713E66801F396B1" modified="2020-04-22" version="1">MRNAVYSIGLIAIMLAGCQSHPYQEMEERELASGVRYDTLLMGMTFGMSLQDFFDRCMDLNRQKLIYQGPGARIVEYVIKENVKSPVTVQFQPSFHEDGLYEMSYDYFYNAWAPWNTEFGADSLILTVKSLTEETFGGGFLAIEHPEKPTAYAKVDGNRRISISLKDERRVSVRFTDLTVAKQLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E372</accession>
    <name>A0A654E372_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="42415" checksum="99F826A98113555A" modified="2020-04-22" version="1">MKGTLINMMIGVVPIMLVSTLTRAEVLNGQKEIGELKTQEQNENMNKQIASDFSTAFLVDQSPEEVFNTVTNVRGWWSENIEGGTSKLGEEFIYHYKDVHYCKIKLVEVVQNQRVVWHVLENYFSFTKDEKEWTGTKIIFEISKEGKQTKLQFTHQGLIPAYECFEICSDGWTNYIDGSLKNLITKGKGEPNPKEGGFNQELVEKWKLDSATSASSDSKDQHLTVSFLVDKTPEEVFGAVTNIGGWWTENYKGGTRKLNEEFEVQFWDVHYSKQKLEEVVPYQKVVWLIIDSKLTFIEKQDEWTNTRVIFDISSVGNQTKVQFTHEGLTPDIECYTDCSSAWNGYLTGSLRDFIMTGKGKPEVRVEQVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E375</accession>
    <name>A0A654E375_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="395"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="642"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="758" mass="86085" checksum="42A5A57558C7AC84" modified="2020-04-22" version="1">MGQTQSATIDLRNADFSKSLSLDGTYEFYWDQLLLPGQLDTLTPGYFPFPSLWNNQFVGDKHLNANGFATYRAIILLPERSDYTLYVEDVYSAFALYFNGKLIAKNGQVATTPEAYLPKWKPQFVALPNVSDTNELILQIANFDHSKGGALEGMQIGTSEVMAAEYLALLAYDLILTGSLLTGGLFFLGLYFFGRRDKAILYFALFCLIYSYRVIGFGYYVLHSLVDVSWYVTTRIEYLTLFLATFAFGRFVHHTFPLEAKKIIWDILDGICLLFIGLTLLFPVSVYSHLVEPFFGILLIYIALTFFIYVRAKINRRPDSTFGLISVGVVFLIFVYNIFVYFGLLEENKAVSFWGYVSFFFSQSLILSFRFANSLKQAKEEAEKASQAKTDFLSTISHEIRTPLNAVVGISHFLLQDKPRKDQKENLISLKYSAENLTSLINDILDYNKLEFGSIEFEEMTVNLKEVITSIYRGYRVKAQAKGLDLNLEFDESIAIEIITDRTRLNQVLNNLLDNAIKFTKEGHVTLKVSRQGESRDRITIRYEVEDTGIGIPEDKLEQIFERFTQASSSTTREFGGSGLGLSIIKRLLELQGVAIQVQSKLGEGTTFFFEQEYTRGVARKVAPVSMEDQEQGMVEKLHGRQVLLVEDNTMNVVVAKKFLKSWHMKIDLAENGEVAVEKASSNYYDIILMDLQMPVMDGYEATRAIRATKNNVPIVALTASALVRVQEKVLHYGMNDYITKPFDPEELRKKLVKNIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E379</accession>
    <name>A0A654E379_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.1.1.184</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.184" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="316" mass="36239" checksum="1306DD2A50A399A2" modified="2020-04-22" version="1">MKYLKFSNGDEMPMIGLGTAGIPADQAYDVIRKAIQIGYRHFDCAPIYKNQAEIGQALHDAMADGEVTREELWVTSKLWNSDHRYNDVEPACEKTLAELQLDYLDLYLIHWPVASERGVEYPQAEEDYLAEEEAPLEDTWTGMEDCQDSELAKHIGVSNFNIEKLKLVLEDCMMPPEVNQCELHPYLPQQTLYDYCRSNKIHMVAYAPLGSPGRPENQTLDNEPFLLTEPAITEIAQKQGCTEAQALLAYGIKRKTAVIPRSTNPDRLKENLESINFSVDREDLRSLIVLTKYRYFKGEEYTIHGSPYKLTDIWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E384</accession>
    <name>A0A654E384_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ORF">MARINOS108_20390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="18079" checksum="A09C35CD2F5ECBCB" modified="2020-04-22" version="1">MSNPQVGIIMGSQSDLPVMSEAAEILEELGIEVEVTIVSAHRTPHRMLEYAENAAARGLKVIVAGAGGAAHLPGMVASLTTLPVIGVPVKSRNSIDGWDSVLSILQMPGGIPVATVALDGAKNAGILAAEIIGAFVPEVSKKLADYKRSLKEKVLESAQTLEARGWKSNKIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E386</accession>
    <name>A0A654E386_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purN</name>
        <name evidence="5" type="ORF">MARINOS108_20543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21538" checksum="8AFBE32D93A4096A" modified="2020-04-22" version="1">MDLNIAIFASGSGTNAEQLVKHFSQVDGINTSVILSNKPEAYVLERAKKLGIPSFTCSKTEFISSAFLKVLARHEVDYIVLAGFLWKIPDYLIQAFENKIINIHPSLLPKYGGKGMYGSHVHEAVIAQKEKTSGITIHLVNEKYDDGRILFQASCDISPEDTPDALASRIHALEHQYFPQIVEDYIRDSTLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E3</accession>
    <name>A0A654E3E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16215" checksum="0DFA8649058FAFB1" modified="2020-04-22" version="1">MENQEIKVPVWFWLVAVIMLLWNLMGVGSFIQNMMMSEEALQALPQAEQDLYANYPNWTKVAFFVAVFGGAIGSLGLLLRKAWSRSILIVSLVAVIAQMIHSLFIAKAMDVYGPGAAIMPVLIILFGFFLVWFSNFGIRKGWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E8</accession>
    <name>A0A654E3E8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">adk</name>
        <name evidence="9" type="ORF">MARINOS108_20725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="21037" checksum="2663B7A1A69977C8" modified="2020-04-22" version="1">MLNIVLFGPPGAGKGTQSENIIEKYKLAHISTGDLFRKHLGEGTELGKLAQKYMDEGKLVPDEVVVGMVEDKIKETLDAKGFIFDGFPRTINQAAELDKMLTAHGLQISGMVALEVPEDELRARIKERAKTSGRVDDQDDAKITTRIRVYEEETSPVAGYYKQQGKFNGINGVGTIEGIFNQICTVIDSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L4</accession>
    <name>A0A654E3L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein required for colicin V production</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="20265" checksum="37FBDC54AC215F23" modified="2020-04-22" version="1">MNYLDIFFLVVFIIGGIKGYMKGFIIEIFSFVAFFVGLFVAIELTIPVANRFFDSSDYYQLLTVGVFVALFLVAVLLINLAAKVIKKAVDLTFMGFLDNLLGALAGIFKWAFIVSVFFWVFDSIGVHLPSGQSDGSLIFPYIESIGPKTFEWISKVLPFMEDMIDSLKNIGEKGKAVYTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X7</accession>
    <name>A0A654E3X7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction and modification enzyme subunit R-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="17395" checksum="61A4C0F662AC4A95" modified="2020-04-22" version="1">MQKLNLPPSDFKLKSEEGNQFIFDIVRKKYLVLTPEEWVRQHFIHLMVNHLAYPKSLIKVETGLAYFKSAKRSDIMLCNREGGNFLLVECKAADVKIDRKALNQVSVYNKELKARYVALTNGMVHFIWEYRSDENKYYQLKEFPKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z0</accession>
    <name>A0A654E3Z0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025071010" description="Beta_helix domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="122"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="518" mass="57155" checksum="366C6406E66A3EF7" modified="2020-04-22" version="1">MKVKSKIYQSTRMVLAVSIIWLGVNSCASNNSDVHTEDLGKEVLYADDLPIYDTSNSAMALIKNLEDWEQVNDEDKSYFFVSPGDYTALGEIVLTQSGSTSAPRWVIYYNPALGQNPMTHPVSLANTDRAAIRQLTVAGNNWQIVGLYGEGYKDQTRTHIIKLQGDSNVVNSVLTEFGSSGGGQIQIVGDYNVVKNSVVRNTMITPGRDNHGIVFTSETDYSQVIGCEIYNCAGDAIQIHPSDDVHKGCIIRDNDIYIDPTKYFEVIDRFPHENGIDFKDGGSSDPKDWVRVERNHFAWIGSTEGGSGGSPGAIDFSNASGHKAYIKFSENVFYECVLPFTTATGSGGGSSNHLSIVRNIFYKASIAAIRPVTQKQFSHEYYFNTIVDVEEPGLWMESEIWNSDIMGNLIINGQNAVIAANKGVNTDYNVFYNTEFLPLEGGNSCMFDISKLDEFGDYCFEFQRFTTPKTLCINKIVPNEKILVASLSDTPVVGANKDRGVDDLILNQNWVGALSPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E409</accession>
    <name>A0A654E409_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="27156" checksum="29497A15F50205F1" modified="2020-04-22" version="1">MEVKKNEHMIYGIRAVIETIHAGKDLEKVFIQKGLKGDLAKELQGLIHGRQIPLSTVPVEKINSFTRKNHQGVVAFLSPVQYHKIDHVLPAVFENRRVPLILILDRVTDVRNFGGIARTAECMGVDAILIPTKNSAQINADAIKTSAGALNFIPVCREANLKEAIQFLKDSGLQIVASTEKAESYFQDIDLMVPTAIIVGSEDEGISSAYLAMADKQVKIPISGEIASLNVSVAAAMALYEVNRQRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E414</accession>
    <name>A0A654E414_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="1">
        <location>
            <begin position="230"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="942" mass="104983" checksum="4F545B886CF7138D" modified="2020-04-22" version="1">MIKVPVYLVLTLLCFYAEGQIVSGKLRREKNSEETVSKSEKQGLSVLEVTLRGQQRKGYLRDTLNQILRRTGQNSYIIRQQKEQKNNLYGISEVEANNLWKLQSRDYLTMPDDWVTYVIKSSSIDILPFLENFGNVEIIDRSRKLFTLKTLNRHLPEIVQNREVLFVSRESLEPVTESRVIDLNLNPNRVNKLHHFFPLLNGSGTTLSIQEDRFDPTDIDLIGRTHISDKSSLEMSQHATEMATIVGGAGNSFITGRGVSPAVQLSSSGFNNVLPQSDLYYQGRGISVQNHSYGTSIESFYGLQAEAFDQNAVRNPTLLHVMSSGNQGALTPQEGLYAGGNGFSNITGNFKMAKNTLIVGAVDTVGHRLEFSSRGPTYDGRIKPEVVSYSMYGSSNAAALVSGTVSLLQEQFSSTYGYQPTSALIKALLINGADDFGEVGPDHVTGFGGINAWKSMQSLLSGNFVSSSVTRDEVSTFELFIPEKATNLKITLVWIDPPAHPGDAIALINDLDLILIDPEGAIYRPWVLNTAPDSLALSLPAVRGADHLNNIEQISLDTPQAGTYTLNINGEGLLIPSQSFEVVYDWDTLNTFEWDYPTGSDNFPYNGETTTYFRWQSTFGSKTGTLEYQMVGQSEWQMIEEDLTLENGHFRWSSLPDDLTGMARARMSIDEAQYETEVFTISRRLNASVGFNCGDSLMLQWPMQDLATQYRVSTLGETHLELLSVVTDTFLLLNGENLTSNHFSIQPVSSTGDTYLPSYTFDYTIQGAGCFLSSFFQEVVLEEGIYLNLTLSTTYGVEKIVFERRVGDNFERVGELVHPESTIIRLLDSQPRQGHNEHRVTLHFQNGQSLSQTASNTYYLTEKPILIFPNPLSNTSFLNVYTRAFDSAPPVFHLYDRGGALILKHTLLTSQESVPIIGVRSGLYFYRIEAGNQSFNGKLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E488</accession>
    <name>A0A654E488_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025103">
        <property type="entry name" value="DUF4011"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13195">
        <property type="entry name" value="DUF4011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="296"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="880"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1331" mass="155382" checksum="4C4CEB34C744D294" modified="2020-04-22" version="1">MEKILQSYLRRLTNLSGNNRSLLLLRLISDQFLDIHDLDFANNEPSFSVIEALIGQKERIKLCDEFDARDKSVNTTSQKLRKIQRIEQFIFQERGARDLYVGWPFVRGKFSDGTLVRCPLIFFPVSLSRGPNGWHLEQRKDVNITFNKTFLLSYAYYNKASLDEELIESVLTDLDRDSTVYRTELYGILKESNLELNFNQENFLDKLLPFVNYKKTDFETDQKNGELKLHPEAVLGIFPQAGSYLVPDYVKLLENPKTTDLSDFFTSRIKEDPEASQNIRFSDQVKEETTFTPFEMDASQEYALKLIKNGNSLTVQGPPGTGKSQLICNLISDFIARGKNVLLVCQKKAALDVVYARLQQQELHDFIGLVHDFKNDRKDIFGQIARQVDSLDEYRQKNNGLDAIHLERNFLQASRKIDQTTEELEEFKTALFDESECGKSVKELYLTSDPEQPSFSLNQQYRQFDYQHAPEFISRLSRFLDYYQKFEKKPHFWISGPSFATFTSQDFVKIKALLEEIPEFELRLKTESLQFAVLALDFETCLHFLSHQQDLSMLRTNLDNETVFQYYKHMMEFDPDEDPLWLSNLERTMLQCFKGDGPEVSLASSELGRFQEALEHAIRARKNLFSWIRWRLFSADKIFITRVLVANELKSNREGFEILLKRIDNRLNYEHIVTKIEKTPWLIEFPKTFRKIDIQNWFFYQKLGLKCIQLTRAVRTITQFIPSKTVDRGSYISALGALLSFLEKIPLQLQRWAKYISEKQVRSILLGKERVEIIQKQLTEDFDALVEYHKLKGGFTREEEKIISELVDRDHEDKQKVISLFENSLALAWIDHIETKYPILRAVSSFKIDHLTQELQQAIEDKMSISKEILLLKSRERTYENLEYNRLNNLVTYKDLYHQVTKKRKIWPIRRVISQFHEEVFSLLPCWLASPESASAIFPMAETFDLVIFDEASQCFAERGIPAMYRGRQVVIVGDDRQLQPNDLYRVRWEDESDDAPELEVDSLLGLAKQYLTEVSLRGHYRSRSLELIEFSNHHFYNGKLKLLPDYHLAKNGKPNIHYLKQNGTWKNNTNQEEAEAVIALLKKLNQSHPDKSIGIVTFNNNQQGLILDLVEQKQDASELTIPDSLFVKNIENVQGDERDIIIFSTAYAPDLKGNLQLRFGSLNQAGGENRLNVAITRAREAIYVITSLLPHQLHTEQTVNPGPKLLKAYLEYAKNVSDGQWQPESQEDTNHHQSWYLRNRLTHTESTAILEKSLPFADLTVKMNDRNQGLILTDDDLFYDTLSAKEAHSYRQTHFVEKGWPFLQFYSREFWINRSQAQEKLEKFIHRMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E491</accession>
    <name>A0A654E491_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 18" type="primary">uvrB</name>
        <name evidence="18" type="ORF">MARINOS108_20903</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="429"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VXD19805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="673" mass="77018" checksum="39DD76CBB06AB4C2" modified="2020-04-22" version="1">MDFKISSEYVPTGDQPKAIAQLTEGINNGEGAQTLLGVTGSGKTFTVANVIEQVQKPTLVLCHNKTLAAQLYGEFKSFFPDNSVEYFISYYDYYQPEAFLPTTNLYIEKDLSINEEIEKLRLSATSALLSGRRDVIVVASVSCIYGIGNPEEFGKNVIKVQEGDTIPRNQFLFQLVDILYSRTEVEFKRGTFRVKGDTVDVFIAYADFAYRFIFWGDDVESIQRIDPQTGEKLSEERIVSIFPANLFVTGKELLQVAIREIQDDMVAQVQFFEEERRFLEAKRLKERTEFDLEMIREIGYCSGVENYSRYFDRRTAGARPFCLLDYFPDDYLMIVDESHVTIPQIRGMWGGDRSRKVNLVDYGFRLPSALDNRPLTFNEFESMLNQVVFVSATPSEYELIKSEGIIVEQLIRPTGLLDPIIEVRPSVNQIDDLLEEIWLRVERKERVLVTTLTKRMAEELTKYMSNAGVKTRYIHSEVDTLDRVEILRELRLGVFDVLVGVNLLREGLDLPEVSLVTIIDADKEGFLRNERSLVQTIGRAARNENGMVIMYADKITDSMQRSIDETNRRRSIQQAYNEEHGIVPKTIIKNREAILGQTSAADKKKGAKKYYTGDEVELTVAADPVVAYMNKDQLIKLASDTRKQMEKAAKDLDFMEAARLRDEMLEIEKMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E492</accession>
    <name>A0A654E492_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="24449" checksum="32E12E73C0BA14B1" modified="2020-04-22" version="1">MVKDIPLFPLNLVVFPREELNLHIFEPRYKQLINDCLLTKTTFGIPSYVETRIEYGTEVKIVEVSKLYKDGRMDIKTSGLRIFKVLDFQNPWDTKQYAGGPVELVECIDDTDASKAIRIVELCRELFEWLHMEEEIGLGETAVMYDVIHKIGLKPEEEYQLLKMSSESERQSYVINHLENLIPALERAEKAKEKIRMNGHFKHFDPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C3</accession>
    <name>A0A654E4C3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="27581" checksum="32E2DD108BABCDE1" modified="2020-04-22" version="1">MIELFSFQFTYLEFGFFLCVPFLIGMAKTGIHGAGMAAVPLLALVFGGRLSSGIMLPILCIADIFAVAYYNRHANWTHLGKLFPWAAGGVILGTYVGGKIDDQAFRMIMAVIIFVSLAIMVWREKSTNQHIPQGIWFAALLGVLGGFTTMVGNLAGSVMALYLLSMRLPKNEFIGTAAWFFMIVNLFKIPFHVFAWETITLDSFLLDLTSIPAVALGAFVGITIVKKIPEQYYRWFIIATTALAALMMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H0</accession>
    <name>A0A654E4H0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="16194" checksum="1B4E9A2FEC760C3E" modified="2020-04-22" version="1">MNILGGIPKQGDQSLVYLVEHKIINMRFPSFIKVPKTRRFEIEPRYYDPVKEQIKERTEYIRREMEGGHSESYSPGKISFQRKTDAVPNTSLLQMLIAAILGCLVMGWLYFGNDALYVLWLAVPVYLYFRFKKPSRGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I5</accession>
    <name>A0A654E4I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="105" mass="11858" checksum="C34E56DC82221CDD" modified="2020-04-22" version="1">MKEISVKELKQMMDSGEDFQLIDVREPNEFEVAEIGGELIPLSTVPDNADKFSKEKKVVVHCRSGKRSANAIQYLEQQHGFDNLYNLAGGILAWSDEIDPSVQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L2</accession>
    <name>A0A654E4L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_60091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="69"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="302" mass="33214" checksum="FA62D76DA75FEE8D" modified="2020-04-22" version="1">MNNSILDDFKNAWNKPNNAPAQLIIINIIVFLFLGVLMVISRLSNADALFSVIYNQFSIPPSFGEFLTRPWTLITYAFAHSLTGILHILFNMLVFYWFSKLILEFLGNKKVIAIYVLGALAGGVAYLLVYNLIPFYQEQVASISGMVGASAAVYATVVAAAVFMPNYTFFMLFLGPVKIKYIAAFYVVVSFLGSTGGNAGGNIAHLGGALIGWLYISQLRSGTDIGAWIIGFMEWVKSFFVASPKIKVTHRGEPAKSKPRKSAAGSRSEQEEIDAILDKISQSGYDSLSKEEKQKLFNASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N7</accession>
    <name>A0A654E4N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="28384" checksum="1A45DD1EDC140809" modified="2020-04-22" version="1">MSLVLKTVAQDEHPVIGVLVDSATRQPVQFAHVTNYSTNQLTVTNVQGRFRIPASVGDTIVFSIVGYQTLGWIARQEWLDKEISLALPQDTLLLNDVIVQNIPTEEIFKRKILNYQPEDTSFWYHGMPLPVAKEDPMLNEKTIKNPLYMATHPLSAMYYNFSKQEKEKRKYHRVIQNEHREQRVSAKFSREWVHEVTALEGNELTDFIFYCDYSLDYLDKTPLYLIREDLLAKLTEFKRDQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R8</accession>
    <name>A0A654E4R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ORF">MARINOS108_20604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="278"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD19173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="37266" checksum="55A84B601195486E" modified="2020-04-22" version="1">MQRALELARLGLGNVSPNPMVGCVIVKDDKIIGEGYHEQYGGPHAEVNAVQAVKDQSLLAQSTAYVTLEPCSHFGKTPPCADLLVRHQVKRVVICNEDPNPLVAGQGIERLRNAGIEVEIGLLREEGRVLNRRFFTAFEKKRPYVILKWAQTADGFVARENYDSKWISNTYSRQLVHKWRAEEDAILVGTNTARYDNPSLTTRDWKGKNPVRFFIDRTLLLNKGMHLMDGTVPTYCFTEGEGENRQNLTFIQQEQIAPEAILASISELKIQSLIMEGGSGLLNSFIERGLWDEARVFIAPHTFGKGIAAPHISGELLSAEDVLGDRLLIYKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V1</accession>
    <name>A0A654E4V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol reductase thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="11500" checksum="CA647D50EA438AEB" modified="2020-04-22" version="1">MIELTEDNLQNILAENERVMVQYGATWCGNCRMIKPKFKRLAGEHEQVLFVYVDAEKLPASRSLAEVKNLPTFAGFKNGTLVSQAAGNKEETITTILNEIANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5X0</accession>
    <name>A0A654E5X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TonB-dependent receptor plug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025000662" evidence="1">
        <location>
            <begin position="20"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="625"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="807" mass="90276" checksum="2C28B4227072545A" modified="2020-04-22" version="1">MRKFFALTIFLLHATYHFAQPIETLVVDELTEYLELRPQEKVFLHTNKQILAAGETLWFKAYLTDANTLKASKLSKVLNVELIDQNQRILYSRVLKLENGSGFAEIDLSDSLPDGDYFLKAYTNYMLNFDRSLLYTQPLKIINKWVAYPKAEDPPTAFDVQFFPESGYLVSGLITSVGFKAINEKGLGVSISGEIVDDQANKITDFQSQFAGMGSFKLIPTIERTYTARVSYQGSVFEFPLPTVRPNGAIIQVTPALEKMTLKVLTKDYSLENHFLLGYQRGKAVMLLKPDPTNSYMYSSFSTANLPTGVVYFTLFDANGLAIAERLSFIMSQGDPTLTIENTEKNANRSKTSVSLSMDHLGEYNGLADLSVSVFKASLDLPMKNTIQTHLLLSSDLKGHIEMPQYYFADVDMEKVEALNNLLLTQGWRRFKWATVINKDLPEIQHFLEQHQSISGQLFKYYNRQHSAPGNVSLTVLENPLINATVETGEDGRFQFAGLDFQDTVSIILQAQKPGKKAKKDPTKEKNDAYYIKVNQRKIPPVVIPLVPIPEAEMDDAISDAEAQMNRIREIEAAFSEGGAIMLDAFEFKSSKNPYDDPVSSRALMYNNPTTRVELDSMPVDPRLGAASMADVFNALQIPGFNTTTMQSRGASTFSGSNTVAFFYDGMQVDKEFVMQDLSPSDVGSIDYFTGAKASIFGAVGASGVIAIYPRSEQSYANLDVVGITNFKLPGYYQPREFYSPNYDVITEEKPDYRATLYWNPAVQTDQNGTATFSFFTSDEDAEYLIEVQGLTSDGSPVFRQSYLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E697</accession>
    <name>A0A654E697_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6040" checksum="837E2F0AFE00E08A" modified="2020-04-22" version="1">MGEILVKSEFIELFLHFKLITNIEREKDKFINGSLLDSGGVTTPLIIKNKIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6A5</accession>
    <name>A0A654E6A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HHIP-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="610"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="865" mass="97131" checksum="7F71030508431AB7" modified="2020-04-22" version="1">MKRLGLLGLVGLFLSCGQTTHETKKEEAPEESRFVKEVFATNLYEPTELVVLPKGKVIFTQRRGGIKQYDLRTNELSDYDSIPVHHEKEDGLMGIALDPEFEQNDWVYLYYSPVGDEPVQHLSRFTYTAKGLINEVVMLKVPVQREECCHTGGSIQFGSDGLLYLSTGDNSNPFDSKGFSPSDERPGRSAWDAQKSSANTNDLRGKILRIKPEPDGSYSIPEGNLFVDDDPLTKPEIYVMGCRNPYRISVDPKRGWLFWGDVGPDAGEDVEGRGPRGHDEFNVAKEPGFFGWPLFVGDNYAYNEYDFSTGISQAKYDPAAPFNNSPNNTGLQNLPPAQPAKIYYPYARTDIFPQVKNGGRNAMAGPVYYSDMYEGRSKFPAYLDGRVIYYDWMRGFIYFLELDEEGNPTDWYSFMPNTEFNNAMDMEFGPDGNLYMIEYGTGWFTRNENAKLSRIRYIESNRPPVLEASVSRNSGSAPLEVRFDASGSKDYDGDKLKYQWEIEGETFNDSVFTYVFEKEGVYYPELTLSDGKGDYRTQQFTIEVGNEPPAVDIAITGNNTFFWQGRNIAYEVQISDLEDEKGAGISTDQIRFDINHYQSTDMAETLGHQVPVSNGLTLIESLDCKGCHKVNEKSIGPSYTAVADRYKTDRNAVNYLSRKIISGGGGVWGEQAMSAHPDLTTEDAASIVEYILSLGNQMSYPLEGTFKTSEATGRYLFTAAYKDRGKAPLRPIEVTRNIWLRPSRMPADLFDDSKDIQARGGEIRSIYHGSWVSFNNLDLTGIGSVSFLLANREKGGTVSIRTGAPDGVEIGRGEIYPDRSNGPTSTLEIEIKDVTGFQNVYFVFTNEGEENKLLYIRNIEFNPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6F0</accession>
    <name>A0A654E6F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyanate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="404" mass="43626" checksum="0A368027C3A2F682" modified="2020-04-22" version="1">MENQLNRNRLFIASCFALLTTAFAFGIRAGIMNDLVTDMSLSDQQLGWINFMGIFGFPIATLVGGPLYNSLGPKKIGNIAFLCHFIGITFSILSNSFYTLFFSTFFISFANGMVEAAYNPLIASMYTSNRATMLNRFHVWFPGGIAIGSLIALSLGLLGGSWQIKIAVMYVPAFTYFLLFRGQAFPEAPKETTMSTAENLKAIMSSPIYWLMLVCMALTATTELGTQSWVERILANSGAQPLLVLALVTVLMAVGRMFAGPLIHRLNITGVLLGSAIISALAIFMMSMATGPMVYVAAVLFAIGVCYFWPNMISFVADYLPKTGALGMSLIGGVGMLGLSIFQPIIGGWIEGHRAVKSAEGLTGEALELAAGQATLANIAIIPTLLIGVFLFLFLYVRKNKTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6Q5</accession>
    <name>A0A654E6Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="5094" checksum="0378582E6DFC060E" modified="2020-04-22" version="1">MHDFWKVIALRGGYEGGLFLGSVIKAVELYEKRQLERAAFSNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E777</accession>
    <name>A0A654E777_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-barrel assembly machine subunit BamD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YfiO" evidence="1">
        <location>
            <begin position="35"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="32145" checksum="A94DAFDD54626E61" modified="2020-04-22" version="1">MRRLSGNILLILLLVASVACTKFRKIQKSGDWKVKYAAALDYYENKDYFRSNTLLEEILPIIRGTEEAEYANFIYGYTFYYQKQFILSAHYFKLFTEIYARSEYVEEAAYMAANSLYMQSPQASLDQTSTYEALTSLQNFLNKYPYSEYADEADQHINTLQVKLEKKAYENAKLYHQLRRYKAALIAFDNFQYDYPDSKYNEELAFLGIETAHELAGVSIKSKQEERYKKVVELYQKFIDKFPNSKFLKEAEEYYGDSIEQLTIFADQNNQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7D1</accession>
    <name>A0A654E7D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="28538" checksum="637D7DE5D7E4D9B3" modified="2020-04-22" version="1">MEHSEYFPYTELFKEKLSIARIAELVLSFYKRLAIENSDFNKLYLVSERPSLYDSIDIQKSDAQKILADEILNQNIEDIRKQDKVENPGIDYSRDASVLFSLEAKTGKETLIILNFSFGTKIKSSIGAIAINKYCFDSYDKAKFFLDAEVAVFNVIYSILKIRERDFTRKTRAFKVPLGWITYFSDDSEWGIPDDLGGIEYEHVDEGKYLILSREDITSDSEKLGAGKQKLLEVMEEIKRRVPEYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8J6</accession>
    <name>A0A654E8J6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">ggt</name>
        <name evidence="6" type="ORF">MARINOS108_110007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024810316" description="Glutathione hydrolase proenzyme" evidence="5">
        <location>
            <begin position="21"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="561" mass="60779" checksum="E86E1F6AA11D9CCF" modified="2020-04-22" version="1">MTSRIYILLLLALTFSSCNLTTSPKVGALGDHAMVVSAHPLSTAVGLNVLKQGGNAIDAAVATQFALAVVYPRAGNIGGGGFSVIRLTDGSIAALDFREKAPAQAERKMFQDSLGNVVGELSTIGHLAAGVPGSVAGMWELHQKYGSLPWADLVQPAIDLAFEGFLITANEAEALNEKQEDFRQANHYRPWVVRENGWQANDYVNQPQLAATLSFIRDSGRDGFYKGIVAQQIVKEMQRGNGLVTHEDLQNYEAIWRTPLVGTYRGHRVISMPPPSSGGVAVLQMLQGAELLNVGRYEHNSTNAVHLMAEIERRVFADRSKHLGDPDYFQVPVQQLLSPDYNASRFADISIDQTTPSTDMQGGEVPYESPETTHFSIVDADGNAISTTTTLNLNYGCKVWVKGAGFVLNNEMDDFSSKPGVPNFFGLIGAEANAIAPGKRMLSSMTPTIVEKDGALKMVLGSPGGATILTSVFQTVLNVIDYEMTMQEAVSAKKVHHQWLPDQIKAETDAISLKTIEELEQLGHSFEFVDKIGRNDCILVREDGRLEGGADPRGDDKAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9V5</accession>
    <name>A0A654E9V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024976144" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="413"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114983" checksum="8CC84C4EB218C258" modified="2020-04-22" version="1">MMKKLLNGFLLLLATMCATDLLAQEVTISGTVTDQERGETLPGATITIENEYTGTITDIDGKYTITTEANATLMFSFIGYETKKIKLSGQTRLDVALAADLQSLEEVVVVGYTSKRKKDLVGSVSVVDMEEVGKIVYANPLQALQGRVAGVTFNQTGEPGSVGTSVNIRGFTTFGDNTPLYVIDGIPSQEPPNNLNGNDIASIQVLKDGAASVYGARAAAGVILITTKTGKKDKLEIDAGVILGRQTRANYLDLLNAEEWGQVYWEAYKNSRNGTPSFTGYFDLGGKPGIPADPQLYQPDKDDPSKDQSYLYTPEGTNWADRIYRDGQSQQYYVNISNGNDKGNVMFGASYFDEQGTIITSYFNRITARLNSNYNLTKWMKVGENLSISNSERVGVGGAANDVVRQHPALPVYDTDGDYAGRVGDFPDIRNTVSQLDRNRNNTTKSWRIFGNAHGEVSLLDALDILPEAHAFKLRTNVGLDYSDYYDDFFGSSLHEGVYQIDNNSYFNKYGRGVTLTWNNFAEYSFRKKDHNLTLIGGIESIQYSYRDLAASRTGYSSETPSYLTISSGDDIGIAEGGRSNWGLYSEIARLDYIFKERYLATVLYRHDMTSRFATDGDFLTYMVGWRVTDEPAIRRAIGDNVLNDFKLRASYGELGNQNTGTLHNQSTFYGPNDLNANYDLTGTNTSVQQGFVVLTRGNPFLRWETTKSYNIGADVRLFNKSLDFTFDVYQKVTTDLISNPPLALAIGEGTAPFVNSAQVTNTGFDMSLTHFYRSNSGLKITNSVQVSRYKSVVDDLDDRYPLGYEGERYFDSGGRIAEGRQMREFYGWVADGIFQNTEEVEAHANQTGKGVGRIRYADINGDSIINDEDRTYLGSPHPDVTLGLNSQVKYKNFTLDMFFYSSIGHEIYNNLRVTSEFAQIGTYNRTSAILNSWTPENTGATVPMLTLDDKGNDESRASSYFIEDGTFLKMRTLRLGYNFTPKIFEGFNVNLYAEVQNVFTITNYSGIDPEVPGGFDNGVYPLPRTFILGLNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECM7</accession>
    <name>A0A654ECM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016786">
        <property type="entry name" value="YdeI_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021308">
        <property type="entry name" value="UCP021308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22629" checksum="A68B0432324E9A43" modified="2020-04-22" version="1">MDISKTVEEYFARHPEYHAELRKLRAIIHTTELTETIKWGIPTYTINNKNVVGIGAFKSYAGLWFFQGSFLKDEKGLLINAQEGKTKGMRQMRFESIEAIDEKIIRSYLLEAIENQKQGKEIKPEKKPLVIPDELKEQLSKDGKLSEAFDQLSLSKKRDYTEYIQEAKRPETKQNRLEKITPMILAGMGLNDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDP0</accession>
    <name>A0A654EDP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">grpE</name>
        <name evidence="6" type="ORF">MARINOS108_20727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22287" checksum="641F7E8ADC7983AE" modified="2020-04-22" version="1">MQKEKVEEKELDQNIEVNQEENTDQPVTENEESGAEAATAEEEPTELEKLSIELSEAKDKYLRLYSEFENFRRRTAKERIELIGSASKELIESLVPVLDDFERGLKSMEENEEMTPAKEGTELIYNKFKKILESKGLKKMEVNKGDDFNDDYHEAITQIPAEEELAGKIVDVVENGYFLSDKVVRFAKVVTGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFA1</accession>
    <name>A0A654EFA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="316" mass="33479" checksum="5298874546E80C71" modified="2020-04-22" version="1">MKNVFKNLMIYGAVASMAFLYSCGGDEETPAPAVPTIAVATTVNGTAATSPLNVVPGDEVVFNVSINAEGGFNVYRVYASKDGGTATKLAEYTRLDLSVDAGVAVVTDSRATEIEAEDVGSTITYEFEVVDDKDQTSTTEIEVVVNSPEARIYASKKLLAPSGDFTNENFFSVSTGELYSKSEVNSTTEAISPLIDFGYYYGNSENASIASPKGFESTVFASQVEGWNTKNATVLKTTTLTASQFNEVSTYADIDAAFEAGTLDANGVITGLTEGTVLAFETVDGVKGLILVSEIEPGFESNDYIELDILAQLEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFJ5</accession>
    <name>A0A654EFJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Voltage-gated sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="PTHR10037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="6">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="32234" checksum="EDA13ADAD6A0EEFD" modified="2020-04-22" version="1">MLIWDRVKNMDDLRAFIESKAFQYSIIALIIINAITIGLETSATIRESAGLWLTEIDKYILVIFTLEISVKIVAYRQKFFANTWNIFDFLIVAIALIPAAGPLHILRTLRVLRTARLIKNVPKLRLIIESLLKSIPSIGWIGVLLFMIFYIFAVIGTDLYQDQFPEYFGDMGKTFFTLFQVMTLESWSSGIARPMMQEVSYSYLFFIPFILLATYTTLNVFIAIVVNTMNEINRAEMKEEEERVKDFVHQEHEQMLDYLSSIERKITQLEKKIDQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSN4</accession>
    <name>A0A654DSN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="143" mass="16160" checksum="EDEECF0D8A4075F0" modified="2020-04-22" version="1">MKNVFVLLAGLTSLTFGIYLFQSRLSFIYRATKTEGVITEIESRRTSSKTYYYPIVSYRDVEGDQQTMHFDLGTTGGFDYSVGETITILYIPDEPDSAKVWVFWEMWGVPSVLSGVGIIFILIGIGNLRGYFSQKQNPEVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSV9</accession>
    <name>A0A654DSV9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">bioB</name>
        <name evidence="16" type="ORF">MARINOS108_10172</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="38"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="36404" checksum="B985430926DFE2A2" modified="2020-04-22" version="1">MEIRNDWTKEEIKAIFDKPVLELIYEAATVHRQHNDPSEVQVCTLLSIKTGGCPEDCAYCPQAARYHTDVKVHKLLDVDFVMEKAKKAQESGSTRFCMGAAWREVRDNRDFDKVIEMVSGVNSLGMEVCCTLGMLTETQAQKLKDAGLYAYNHNLDTSEEHYEEIISTRTYDDRLETIDNVRKAEISVCSGGIIGLGEANEDRIGMLHTLATMSEHPESVPVNALVPVPGTPLEDQEKVSVWDMVRMIATARIIMPKAMVRLSAGRVRMSVEEQALCFLAGANSIFAGDELLTTPNPEVDQDKAMFQTLNLKPRASFKGAAAEKFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSX7</accession>
    <name>A0A654DSX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009921">
        <property type="entry name" value="DUF1456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07308">
        <property type="entry name" value="DUF1456"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1456" evidence="1">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1456" evidence="1">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="18610" checksum="A3D197EF024654F2" modified="2020-04-22" version="1">MNNNDILRRIRFTFDFSDSQMISIFAAADTEVTRAQISDWLKKEDDPDFKQLYDKELAIFLNGFINKKRGKKEGEQPKPEKSLNNNMIFRKLKIALNMKDEDILEVFSLAELKVSKHEISAIFRKPTQSQYRLCKDQFLRNFLHGLQIKHRPQDTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT17</accession>
    <name>A0A654DT17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane receptor protein involved in Fe transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="356"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="869" mass="98025" checksum="8CCD68670B0FC923" modified="2020-04-22" version="1">MPKFLLAFFVLIFSLFCTTGTAQEILKRPITLATYSYTLDSALQTAKAQGFPIAYSSSKLPNARCNFKSSQLLYEDFLKALKTQTGINYTVNGNIVAISYEKPTVELQTIRGTVRDLESGEALIGAAVYEPGSLNGVITNSYGYFSLSLSAGEHVVRVSFIGYEDILDTIDLSKGHIRNFMLAQKVNELNEITISAIEPDFNVSSLIPGINTLNLSTEGQIPYFLGEVDVLQGATLLPGIKTLGEDANGLNIRGGSTDQNLILLDEATVYNPNHLYGLISVFNPEAVNNVEIMKGFIPPSYGGRASSVISVHQKEGDDQNYHFTGGIGLVSARFIAEGPIKKKQSSFILSGRQSIFDLSLDNNTSTSFQDLNAKINLKYNKKNTFYFSGYFGNDRNTNTFETVRNWGNRNFSLRWNHLFGRRVFANFSAILSEYNYKITQPREAASFIGKSRIIDYTAKSDWGYVITPKHELKFGGSTIFHRLKPGDRIPFDEQTSSSNPLYLDSEHGVESAIYLSHEATLGKKFSALYGFRISSLHYLGAGTIYQYDPELPRSNESITDTLTFGALEIMKSYYGWEPRASVSYRLSEQASIKASYTKSLQYLHLISSTITPAPTDIWKLSDSHIAPTTSHHYSLGIYQNFKDNKWETYVDGYFKRLVNMVQYKDGADLLFNPNPETELLTGMGRAYGMEFFLKKNEGKFTGWLSYTLSRSEIKVAGQFDEETINNGRYFPSNYDKKHDISLVGIYKFLPRLSGSFSFKYNSGRPFTLPLGKYIYEGNLIPHFGNRNQSRLPDYHRLDLSVKWQGKQFKADGTPKRFEDYWTLVVYNAYGRNNVYSYFFKEDKQSGVTTIEPYTIFDSVIPAITYNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTW8</accession>
    <name>A0A654DTW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AraC-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="159"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="31457" checksum="39C5B7A0FAC342B3" modified="2020-04-22" version="1">MNYQIILPSYALSNYVSYFWTLQYSGGLGEEIVFNSFVDNSTGIIFQHNQGKSAFYQKGKGELLTSFVYGPSTKPTVTFGADVFELNGVLFKPGGLRALLRMDTDELTDEMVCIDEFAEGCGLADHLLNIQSTEQRMEVLEQFLIRRMSNSLAFDQLIHHSLDLIHAQIDTIRMLDLCKTLKLSDKQFERRFKRSIGVTPIFYTRVCRFQNAMELIKTGQYNKLGDVAYALGYSDQSHFIKDIKQFSGYAPRDLSQQVSDFVVNLNKPLGLQSEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU35</accession>
    <name>A0A654DU35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024888978" evidence="1">
        <location>
            <begin position="21"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="120"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="715" mass="79520" checksum="0EB773DEED6D6D24" modified="2020-04-22" version="1">MRQYLITIYLAIFSQTMVLAQSTVSGVVSDQKGETLIGANVYLKDTYDGGTTDANGRFNFDAYETGAQVLVVSFMGFESVELPFLPDQENHFEIKLKEAFNTIDAVTISAGSFEASDKKKVVVLQSLDIATTAGATADITGALNTLPGTQTVGESGRLFVRGGTADETKIYVDGVEASNYYGASANNIPTRSRFSPFLFKGTFFSTGGYSAEYGQALSSALILNTLEVDPVSKVDLSIMSLGLEAGVTKAWEEQSLFAKVGYINLNPYNHLIDQRVDWKQGVVDWNTNVAYKKNLSNGGRLKALAMGNTSSMSLEQKTILNPSGVNAIGVNNKNGFVSANLELPVGETDHVYLGASSSWNEDHLIYNQTTIERPTFNQHLKAKYVHEFAPKSILNTGVELYYQHFEETIADSISLKFDYNQAHTAAFAELDQYITQNLVVRVGGRLSYLSLLKEARLAPRLSMAYKLDEYAQVSLASGLFYQAPGSEYLKLTDELNQQQAAHYILNYQRIKENKVFRVETYLKDYDQLVRFQSPYDPSTFSSDGDGYAYGLDVFWRDRGGIKNIDYWVSYSWMKSERKYLNYPEKTAPGFTSAHNFSFVIKRFFPLLKSQMGATYSLTSGRPYENPNLDGFNESRTDGYHDLSFNVAYLPTPRVVLYASATNLLGSDQVFGFNYASQPGENGMYASEAIRLPAKRFIFIGCFITIGAFNNQLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU49</accession>
    <name>A0A654DU49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7494" checksum="9AF25879A37714A1" modified="2020-04-22" version="1">MNQMRFNMRENDIDAQDYMEYDDVPDSYFSDLEEDNESLDNDAEPDRAGGDYHSEEYRSISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU57</accession>
    <name>A0A654DU57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="274" mass="31368" checksum="EBEFF2705F2A07D1" modified="2020-04-22" version="1">MKILDWNPGKDTLLKGKEIEVHEIYHSHLASQELTKAKILKNSKRRMRARSLEKALRKIGKPLNGKVLELGAGDGWCSAYMLSKYYAQLSEMHTMEINSAAINQLIPKVFDVVGVNTEKSTLIHGSFNNIQLENYYDYVIVMGAIHHSSNLYRTFMEIQKALKPGGWLIAQEPYMVDDTMNSFYTKRQNKVDNFKGLTEVRNGDRSDIFFRSCEYRAAAFHAGFDYQTFGIPDLSLWYFKRALLGQNVGRPKNMTIYAQKPLTGLQLPTPTGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUD0</accession>
    <name>A0A654DUD0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">trpF</name>
        <name evidence="6" type="ORF">MARINOS108_10254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22753" checksum="664B9047ADE94E4B" modified="2020-04-22" version="1">MKLKVCGMREADNIRDLLELEPDYMGMIFYEKSPRCVLEMPKADLSGVEKVGVFVNASDEEIKEKAQTYGLDLLQLHGEEPVDQVKRLKEHGFKLIKVFSVADELPIASMQAYSPYVDYFLFDTKTPAYGGSGQKFDWGILKDYDLEKPFFLSGGIELDDLDAIRQLGMRQLYAIDVNSRFELAPAVKDIKKIKALKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR8</accession>
    <name>A0A654DUR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17383" checksum="00EAA5F8F864FCEB" modified="2020-04-22" version="1">MIKEFENLREEEIDVLLTAPVYVAILIAGADGNIDKSERKEAIDVAHSKQSRAREQLVDYYKLVGESFESKFNKLIDELPESAEERNKVLTAELRKLNFILPKMDKNFGVKLHASLKELAKKIAEASGGVLGYLSVSYEESKLIELQMIKEPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV03</accession>
    <name>A0A654DV03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3347 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024885447" description="DUF3347 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="3">
        <location>
            <begin position="63"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="21713" checksum="FA184090EBC3C098" modified="2020-04-22" version="1">MLVLILSVSLSLSLIACGNSNQNNQEESAKQHDHSAMSHEADHSMATGSEMSMEENKSITDLIDSYLALKTALVQDDSKAAANAGQKLAEATSGLDISTFDATKQAAIKEILEVLKEHGEHIAKSEIAHQREHFEGMTKDFMDLLVQVGTDRTLYQQYCPMYNKGNGGSWLSASQEIKNPLFGSKMLTCGSVKETISMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV86</accession>
    <name>A0A654DV86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">punA</name>
        <name evidence="5" type="ORF">MARINOS108_10267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="29910" checksum="74BFA2163715190C" modified="2020-04-22" version="1">MIEKVKETVAFLRESGFEHPELGIILGTGLGALTAHIEVIKEISYDEIPHFPIATVEFHKGKLIYGKLEGKWVIAMSGRFHYYEGYSMAEVVFPVRVMKFLGIQKLLVSNAAGCMNLSWKKGELMLIDDHINLQPDNPLRGKQAADFGPIFTDLSAPYDAEMNKLMKNLATKENIPLHEGVYVAVSGPHLETRAEYRYLRNIGADVVGMSTVPEVIAANQLGLPVSAVSVLTDECDPDNLHPVDINDIISTAQKAEKHLVALFKEVIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV97</accession>
    <name>A0A654DV97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025041116" evidence="1">
        <location>
            <begin position="19"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="620" mass="71110" checksum="8CA02A4C5D5C7542" modified="2020-04-22" version="1">MRFGLPVLFIFLSFHAFTQPFTSDNYYLFPINPGQQNFLAGTMGELRSSHFHAGLDIKTGGQSGLPVHATADGYISRVRVNTGGYGYCLYMTHPNGTTSVYAHLSKFEGRIARYLLDEQYKAESFEVQLFPDKNQFVFKRGEIIAYSGNTGSSSGPHLHFEIRDANQRILDPLKFNFAEIKDNITPQMKNIAFVTLDGAARVNETFGRFEFDAIKTHDVYHTRVPISLKGKIGIEIYAYDLLNGVYNRNGIPETTLVINGDTVFSQSKSSLSFGKQRNILVHMDYEAYRNGGKKYNKLFVEDGNTNDFYNVSSQGFNFSDSTHLIQIYMKDSYGNISTFETEVNNRKVVNLPDPYINEFEIYRDHLHFKNVHQGTPGKISLFFGNTRRPLEPYRTDRRAAYYLWNLHDGLPDSIDYAGKILNTGIYAEIPSGSEISFFNHHSDLFFKQYSLFDTLYLRFEKDYDVQLGLELFRFPHNDTPLRSTVNIRLKPEYSYPENTARVYAVYGSNLSYQGGTWEDGNISFDTRDLVTFTIAEDTIPPVITPRIINSSELYFKINDERSGIKSFRATLNGSFLLMNYESKKDLIWAVRKDENIPLKGEFILEVEDNTGNKQIYQRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA6</accession>
    <name>A0A654DVA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="78" mass="9110" checksum="FB9A0ECC58C573B3" modified="2020-04-22" version="1">MRSIGHLCEVFEWWVFWDQFKVLLNCSTLNQKVSNNDETPTTFSYLEQSINTPAAEEISLFAETCYGPDLRDTTFRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVG4</accession>
    <name>A0A654DVG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase-3 subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="30489" checksum="A0A77019943CD3BD" modified="2020-04-22" version="1">MLKLKNPLVVFDLETTGTNIANDRIVEMALLKVMPDGTVEEKSRRINPTIPIPLETSLIHGIYDEDVKDEPNFKQVAKSLATWLEGCDLAGFNILKFDVPMLVEEFLRANVDFEVDNRKLVDAQKIFHLMEKRNLSAAYQFYCGKPLENAHSALADTQATYEVLMAQIDKYEGEPVKDLLGKELGTIKNDMNILHELTNQKMVDLAGRMVYNDKGEETFNFGKHRGKLVSEVLQKEPSFYDWMMKGDFPLDTKRRLTKIRLRNNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ3</accession>
    <name>A0A654DVJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046239">
        <property type="entry name" value="DUF6272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19788">
        <property type="entry name" value="DUF6272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21819" checksum="CF3BCA17D5CB1E62" modified="2020-04-22" version="1">MDYLRSYKNIYDQNIILMYKGELTFDLVTSMIATLEERLEELEENRKVKKKFYNVATECIQNLYYHLDEVNADEIRISSYDSRSALILIAARKRFYSLQTGNYIPTERTAEIQQRLDDINAVEPEELRTLYKKALNEQEFSDKGTGGLGFIDIARKTGGQKLRYKFQPVTDNVSYFTLQVRLPRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT3</accession>
    <name>A0A654DVT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/glucose cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sglT</name>
        <name evidence="8" type="ORF">MARINOS108_11096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="537" mass="58541" checksum="DC024ED285930C7B" modified="2020-04-22" version="1">MEFSFVDIIVFISYCLLIVGIGLWVSRDKKGHEKNAEDYFLASKSLPWWAIGASLIAANISAEQFIGMSGSGFASGLAIASYEWMAAITLIIVGKYFLPIFIEKGLYTIPEFVEKRYSTQLKTILAVFWIALYVFVNLSSVLYLGALALETIMGVPMMYGVMGLALFAAAYSLYGGLSAVAWTDVVQVVFLVLGGLLTTYLALDTLSNGAGMMAGFKQVWEAVPERFHMILDESNPEFSNLPGIWVLVGGMWVANLYYWGFNQYIIQRTLAAKSLKEAQKGIVMAAFLKLLIPFIVVVPGIAAYVMVNDPEIMARLGELGQVNIPGPGESDKAYPWLLQLLPVGLKGVAFAALAAAIVSSLASMLNSTSTIFTMDIYKQYIKKDATDRQTVRMGRISASVALVIACIMAPLLGGIDQAFQFIQEYTGIVSPGILAVFLLGLFWKKTTNAAAIWGAILSVPIAMLFKLLPGIPFMNQMGLTCLLTMLVIIIVSYLGGKGKDNEKGIELTKDLFKTTPAFNIGAFAISLILVVLYALFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU7</accession>
    <name>A0A654DVU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="1">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="224" mass="25467" checksum="ED975B56A8374969" modified="2020-04-22" version="1">MHQIRLMRPGSDGHIINEYGLPEKPPHDWGFLPAGDAAVTRKVTALGDCWRIQIKKGRRLQSLGIWAPKDNIIRAKQEVKNMRSTPDYAKKRARAAKSRDQKQAAYTAEFEQAVINFLNFHPVYKAFETQMAKLITAHAIPIGSGTVARTQMIPLSERASRAVTAWMRHQTTEYDRMKIARVKGERRAVRRKLAERSSGLLKAYRKGEPIAPECPLQKALKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW54</accession>
    <name>A0A654DW54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major Facilitator Superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="245"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="47804" checksum="2910209743ED0EF4" modified="2020-04-22" version="1">MKKPGLSTAQIWNMSMGFLGIQFGFALQNANASRILQNFGADVEHLSWFWLAAPVTGLIVQPIIGHYSDRTWNRMGRRKPYFLTGAILASIALCLMPNSGALASFIPPMFVGAGMLMIMDASINISMEPFRALVGDMLPTEQRTQGFSVQASLIGLGAVVGSFLPYMLAEWVGVSKVAPAGVVPDNVIFSFYFGAVVFIATILWTLAKTKEYPPEEYAAFNGQEESKEKGSIMDIFRDFAKMPKTMKQLGLVQFFSWFGLFSMWVFCTPAIAQHVYGAGAEDSSSVAYNDAGNWVGVMFTVYNAVSAVVALLLPAIAARVGRKRTHAIALGLGGLGLLSIYFFPSQPVTLVAMVFVGLAWASILSMPYAILAGAIPGGKMGIYMGIFNFFIVMPQIVNGVIGGPIIKRLFDSQAIFALIIAGGCLLIAALTVNFVEDKDEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB4</accession>
    <name>A0A654DWB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024827733" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="23537" checksum="50F5436F6C87854B" modified="2020-04-22" version="1">MRRLFLFMIFCAAGFLSHAQEFSSEVWHDGYLITTEDDTVRGLIKYDMEANIVQLIQGNVVKTFSSHKIFYFEIYDKLVDNYRQFYSIPYNVNYNYEIPIIFEVLYEGPLSLLSREAIVQESVSNSSAYWGGSFIQDKVHYTFYFLHKDGKIDIYLGKKSDLMNIMSKHSSEVKSFIKKNRLKTDELRDLIRITAFYNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK9</accession>
    <name>A0A654DWK9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_11047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="12433" checksum="6F884A16EB3741B6" modified="2020-04-22" version="1">MYALIISIIILVAFLLILVVLAQNPKGGGLSSQFGGAGTQQIMGVKKTGDILEKLTWGLAIAMLVLTLSTNFFVEDNTQTLTSPNIESAQESVLPTQNIQSIEQPSGDLGLEEDSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN6</accession>
    <name>A0A654DWN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="463" mass="52450" checksum="03672132270F9074" modified="2020-04-22" version="1">MKYYTLLILFIAGGWLARAQEPLSLSDAIAIGLDKNYDIRIEKRNVDVATNNNSWGEAGILPSISLDLQSQNSIRNQQSDNQFFGGQLFPGFELNDQRAYALTPSLQVSWLIFQGNKAIISKRRLDQLQAESMQNADVVVSNTLQAIILAYYMAALEKERLDAFEKQLALSKDRYDYTNTKYEMGSAVTTDLLLEENNYLTDSANYINQMLTYHNAIRALNVLLVSDDINKDYTLTDDLKLEEYDYQYEDLEAVMLSENVDLKKIYISQSILETQVRQSRADLFPTVRLNGGYNWNRSVSDLTSATYIGPNPDYENPPEPLVSKSGTYFANFTLSFNLFNGGKVNRAIRNSIVQEDIGNLRIDQLETSLKRSLSEAYERYQIRKQLYGINALNERSAATNLSISQEKFKGGTINSFDYRVVQNNHLAATNQKLQALYNLIDSKVELMRLTGGLISENGSVSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW3</accession>
    <name>A0A654DWW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">araA</name>
        <name evidence="8" type="ORF">MARINOS108_11200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="373"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="513" mass="57515" checksum="3C79126792F7E51B" modified="2020-04-22" version="1">MAKTPITDKTRTNNTMKKLNEYEVWFVTGSQDLYGAEILKNVAVHSEEIAKGLSDSVQIPVQVVYKPVVKSPEEIYQVCQQANVAEGCIGLVVWMHTFSPAKMWIRGLDILKKPLAHFHTQYNTEIPWGEIDMDFMNENQSAHGGREFGFMASRLRKNRKVIVGHWKDESARKKLGVWTRAAAGWHVWQTTKVARIGDNMREVAVTEGDKIEAQIRFGFSVNGYGIGDVVAHLNEVSNAQVEALVKEYNAQYIISPETLKSQFLKDAAKIELGLRSFMEEGGFGAFTDTFEDLHGFKQLPGIAAQRLMADGYGFAGEGDWKTAALLRAVKVMDQGLEGGSSFMEDYTYDFRDGRSRVLGSHMLEICPSIAMGKARCEVHPLGIGGKEDPARLVFDVDAGPAINVSLIDMGTRFRMIVNEVEAVKPEHELPKLPVARVLWDPMPNLTIAAEAWILAGAAHHSVFSKAINTEYIEDFAEMAGVELVVIDKDTKPRQFKDQLHWNEVYYHLFQNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY6</accession>
    <name>A0A654DWY6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="17676" checksum="BA8D030EA2F5CFB9" modified="2020-04-22" version="1">MNTLKIIIPGLILALCACQSSKKEQTNLQPSTALEYDSLLAAEVGADDYGMRSYVIANLIAGPNRSQDSVEASRLQRAHLDNITRMAEEGTLVLAGPFLDDQEIRGIYVFAVETIEEAEALTSTDPAIQAGRLKMELRPWYGSAALMKLKDLHTQVARKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX45</accession>
    <name>A0A654DX45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroloquinoline quinone-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10280">
        <property type="entry name" value="PQQ_mGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017511">
        <property type="entry name" value="PQQ_mDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303:SF4">
        <property type="entry name" value="PTHR32303:SF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="473"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="711" mass="78117" checksum="57A86A94D9F0C323" modified="2020-04-22" version="1">MNRIAGTLIILISLLGAGCNDSATISSDPYKAWDNYLGDAGRTHYSSLTDINRENVTQLQKVWSYEPGDDDGKSYSQCNPLIIGRTLFAASSHFKVFALDAATGVEKWKFDPFEGTDKKDFARGLAAWTDGTQTRIIFTADKYLYALNAETGELVTSFGDGGRIDLTKGLDRDITGLAYQYHAPATVYKDLILMGSLTAETLPAAPGHIRGFDAVTGEQKWIFHTIPHPGEYGYDSWEDTTAYRFIGGANNWTGMTVDETRGILFVPTGSASYDFYGANRKGANLFANSLIALNANTGERIWHFQAVHHDIWDRDFPAPPTLVTVRKDGKSVDAVAQISKSGHVYVFNRETGESLFPIEEKPYPPSELPGEAAWPTQPLPTEPPPFSRQTLTEDDLNPYSNHKEELLTRIRGYQYGGQFIPPSTAGTLLYPGLDGGGEWGGAGYDPTTGILYVNGNEMAWIIKMIELDAEDQDPLTMGKNLYQANCMSCHGADLSGSTFHGAVPALTDVKSRMKPQEMAERIRKGKGSMPAFSYLEEDQVTALIDYLLNWTGDQEEVESNGTKNLEALQYRMEGYQRFVDRDGYPAVKPPWGHLNAIDLNDGTIKWKVPLGEFEELTARGIPKTGTENYGGPVVTAGGLIFIAGTKDPFIRAFDKETGAELWKGRLPRPGLATPATYEVDGRQYVVVAASGGKDTPEKGDEYVAFALPEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX70</accession>
    <name>A0A654DX70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="47"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="28526" checksum="7D9572FFDE44BCBA" modified="2020-04-22" version="1">MIITFLGTGTSQGVPVIACDCEVCTSIDFRDKRTRASIHIEVDGLSLVVDTGPDFRTQILRERVKRLDAVLYTHAHKDHTAGMDDIRSFNFRQQMDMPVYASSEVITQLKKEFSYVFAEQKYPGVPQVKIHEINNDPFNIHGVTVNPIQVMHYQLPVFGFRIGDFTYITDANAIPEAEKEKIKGSKILVLNALQKKAHISHFTLAEAIAMAEELGAEQTYFTHMSHSMGKHRDVELELPEGIDFAFDGLKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA3</accession>
    <name>A0A654DXA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="444" mass="48230" checksum="5458BDD4435A512E" modified="2020-04-22" version="1">MPSNIEVQITHASFGQVEVKGKRKLLNKASILEGASSTNPFVFSRMFLLWAFLGLVGGLIAGVYWITLEFLTHQLSIFQGWQVIPLMAGAGLLAGLIIHFIGDPGEIQLIVNNIRFNKGKLDPKNNPSMILSSLLCVASGGSLGPEAPLVQVTGSTGSWLGKILRLKGEELRSLSIAGMASGFTALFGAPLGGSLFSLEILHHKHVVEHYQAIIPAFVASCFSYVIFAFVVHLGLGPIWDLPAYEIADKFDFALAVFFALFATAVGWGFIFLTKGLKELFQKVVFPIYVKTLIGGIILGTIAFYFPLTRYFGHEQTNHLLEGQFTLSFLVLLLLFKILAISVTVTSGWRGGFIIPLFFTGATLGLIIHHFMPGVSISLTVISCMAAINVCVTRTPLSTTILLASLTGFSYFIPILFASLTGYFLAPKTPFISSQMEESKNHKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG8</accession>
    <name>A0A654DXG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="428"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="537" mass="60546" checksum="6B318C14AE30C432" modified="2020-04-22" version="1">MRTFLNCCFLILLMNLPGCQSPEKHSLTNGFAAQLKLDSTELLVTEVRGNLEVPWEITVGPDGWIWFTEQNGMVNRLNPETGETRVILMIPDVLYKKSLGLLSMAIHPSFSDNPYVYLHYAFSVDSTIKSRIVRYSYVNEKLTSPFVLLDSIPGMTYHNGSRMVISSDEKLFFSMGDAGEKKLSQDINHLNGKVLRINLDGSIPSNNPFTNNPLWTYGHRNPQGLIFGQKGQLYSSEHGVNNDDEINLLKKAENYGWPLVEGKCDLPAEIESCHVCNVNEPIFSWSPTVAVAGIDYYNHTAIPEWRNSLLVANLKGRALRVLNLSEDGSEVLDEHIFFQKVFGRIRDLCVSQNGDIFLSTSNLDWHPQLQPWMYDSLPEGSDRIFRIQVLTEVMKRKLSDQLPVLTLKEDSMALTIEDEVWDFQANSNEISEGQSVYRKHCIQCHQANGQGVNGLYPPLKDTDWVTGDKSRLIQVLLKGLSGKIEVNGQAYQQEMPAFANLSDDEIANVLSYVRSAFENDAGAVIPGEVHEERKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI4</accession>
    <name>A0A654DXI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043772">
        <property type="entry name" value="MBG_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18887">
        <property type="entry name" value="MBG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025026464" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="510"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1513" mass="157379" checksum="3AA015D6D5337CD9" modified="2020-04-22" version="1">MKKLLLPLIVLFISTLEGFAQCTDSTPVWVVNENFANLSGTTPPDCWTPVGNPNSFNFDAGRASFAYQGEMLVLPNTVNATGVLTFKARNGTSRTYGGLTMDLGIYDGATFTKVFAIDYGQPSFQSFTFDFSSNQLNGNIAFRGNNSSNISFLLDDVHYQSTCTSSSSATAMAKDITVKLDASGNVIVNASQVDNGSINSCEAPITNLSLDKTLFTCDDLGANTVTLTADDGFGNTATATAVITVEPALAIGFGTISLSESGQFTLTTENGLSSGTTQCEGITYTFDKTDFSCEDVGGLVVTVTATYEGGTASATRYMEIIDEYGPAALANDINVTIDENTGMAVITADMVDNGSSDNCGITSMQLSKTIFTCSDQGLNTVVLDVFDGGGRTDQATFTVMVNSYIPEVEVSATSTTVCFDGSNENAGTTINTDGSMVGVKYSLRNSADSSVIDGPLDGTGSGLSFSTGAVSENTTFQVYAEVPSSGKALSLPSSADYLAVATPGSFDYSAGYTFSAWVKESLGGISNSYNTIFYAGGTTGSDIEVYQSTQSGVFTVVHNRGNGGTLSTFGTSTNPLPSGEYAHLSVTFDGTTVRLLVNGVEAGSGTILPPVKSAGSELTFGYLNNSGFPGYQSFDGLMDDIRVYDTARTARSISDDMGRCISGSEDNLVLYYDLESVSGTIFTDLVSSTPAQLKNGGTQTDDAAVSCAFDCYKIMSTQITVGDDVAPTVQVQDIEAQVGSTGILSISADLIDNGSSDNCSATSTLIYSLDKTSFSCADLGPNTVTLTVTDEAGNSASAEATVTITSLIADETVTSSVSGLCPGDTEGTTIGIGSSVEGVEYYLRNSADNSIVDGPVAGSGEALNFATGVLSQTTTFNVIGMNAGDAGSGLDFDGMGGYINAGTNARDMITAMTIGMWVKTDHSGSTNYLVGKYDGYRGFLMYINANGNVVLDGRDASGGYKSTGASTTAVNDDAWHYVTGTIDLTTGAWKIYVDGALESSALNGVGSSLFNSQYLTIGALNSEYFRGQIDEVAFWNTALDEDTIALQSDVCGLKNPETSVGFFDLNEGEGTVVTDLSPSAINGALMNMDATTDWISEVAGLECTTCELQMTTEVTITVEDITPPEVVVKDISVRLGEDNTASITAADIDNGSSDECSEITLTLDISTFDASHLGENTVTLTAVDGNGNSASATAIVTVNPYKQAQTITVTAVDDRVYGEADFALSASASSGLDVSYAVISGPVTVSGATVSIIGVGDAVIEVTQAGNDDFLNASAEITFSISPAALTATADNQSVAYGTALPDLTISYAGFVNGEDASVLTTEPVASTTATNSSDVGTYPISLTAGAAANYTITHVEGTLTILKAQATVEISDLAHLVDGTAKEPTITTDPAGLNYVVTYDGASAAPSAIGEYEVSVVIDEVNYEGSATATLVIGQVLGLTNTEVRIFPNPTQQSFEVRSSEKQVVEVYDLAGQLQMRTSTNLVTDVSQLSDGTYFIRILGDDHTVYRLIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ0</accession>
    <name>A0A654DXJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="17010" checksum="62B5BF4A1279BD2E" modified="2020-04-22" version="1">MHKTYFCNGMKYSELKQILKNHKLRVTDSRMDVLEHFLTHKKALSFKDLEEKFSTYDRVTLYRTLNSFTENGVLHKIPDDSGFATFGVCYDTCSSDHHHHNHMHFKCNECGKIECVDEHLPVIELPGYQIQEANLILNGICKSCGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ3</accession>
    <name>A0A654DXJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="10645" checksum="EDEFFACB1FB4AFC4" modified="2020-04-22" version="1">MGIIGIDIPQLNEEQDIEVEVRVNGIKKQYNYRVEIFYWDQCPFPTEDRVECIRQLVNSYDRDWDLAHLGLPTDDYIPITFRKKRNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN3</accession>
    <name>A0A654DXN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="18743" checksum="307A5E7AF17EF38A" modified="2020-04-22" version="1">MENYSASNALKTTKIIHTALMGGCLLFGVVVLVLNAEAPTGSTQDQEFLLYLPPVVLLFAAIVASVLFKKTLKQGLAQSTDLRTKVAAFQTANIVRMGLYEATGLVAVVVCFITGNLYNMAVLLVVLVIFLMKMPTAYRISEEAGLSPKETRGTLRPEGLNERCHSGISPHTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR6</accession>
    <name>A0A654DXR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024907939" evidence="1">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15851" checksum="DC8F385D9191D324" modified="2020-04-22" version="1">MIKTLIKYLLSLCILLLIGHGQLHTPIDDNTFNESFSEFDSQILGVPHHEQGLVFSPATSATKKEVAIMDAAEYEEKEDEKTSSRKHLGPNSHYASHFYTQLPGDYFRYLKKSLALRNYFNFFSSYESLNILLCVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX0</accession>
    <name>A0A654DXX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="15815" checksum="42E9DF6AB8E49970" modified="2020-04-22" version="1">MNLFHQILIPTDFSLAAWHAVQLGLRLIAPENSRLTLLHVFPSGPSERSGDLELMEGLRRQMDDLCQTLERSQKKKIQPVILGGEVEGEVLKFIQANAFELIILGVNSNGVDNEPGSHISGIIAKANAPVMVMPNVINETHQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX6</accession>
    <name>A0A654DXX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="1">
        <location>
            <begin position="42"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="28006" checksum="A6E0AADD3E77CD95" modified="2020-04-22" version="1">MENLLDLVDKRTLTTVVVKQDVRFNLSIMTQKQLLLIILFSIASVRVLTAQSLNFVGRGNLSIGAEYQSIDYNGGDLFYSPGGGIGVELGLQLDIVKGFAIQSTLGYQLHLALQAESVNGVSNKSSFNFNRKFISLGVLKNFKLTDKTVNSLQVGTGASINFPGTLKRTENDNELGESSYHSNFGLYFELALRLKLSDKVYLDPAIRYRRLNFSAESYSNGPITDLPDYLQDLNSNGIELGITFVKKLKSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ9</accession>
    <name>A0A654DXZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024899416" evidence="6">
        <location>
            <begin position="24"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="452" mass="50875" checksum="321CA9613253F069" modified="2020-04-22" version="1">MKKATNYLLVALILIGSACQQKAKEESQAEEVAAISDDERMAWWRDAKFGMFIHWGAYAVPGGERNGEVCKGGAEWIMDKLDYTIEDYENQVVANFNPTQFDAKKWVGMAKDAGMKYIVITSKHHDGFCLWDSEVTDYDIMDSSPFKRDIIKELSVACKEAGIKFCFYHSIVDWHHPQAQAPLYPNYNAGQKDQSVFNPEFPKYYENYLKPQVKELLTNYGDVGVVWFDGDWIPDYTTEMGKEMYNMILEMQPRTIVNNRVDKGRNGMEGMDKEGNFAGDFGTPEQEIPATGIDEDWESCMTMNGSWGYKPSDTNWKSSEDLIQKLVDIVSKGGNFLLNIGPDPQGLFPPESVERLSDMGDWIDVNGEALYGASASPYDRPEWGRYTAKDGVIYAHVFDWPEDGVLKINSEIKVKKASLLADNTQVLSFDESGIALPAEAVDGAVSVIMIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY49</accession>
    <name>A0A654DY49_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="321" mass="37551" checksum="24E00D7C24AAA264" modified="2020-04-22" version="1">MRKKLFISYSDFDKEKIELIISELENHNTFEPLVIASNREALKPLVKKVTDGIESSFVIIPILTAKSISTQWINQEIGYSIAIKKSVKPIVEHQIIKSLKGFIHKQVDLPYSYESQDEKEIENTNFLKAFRDLVSDLESEEEPSGKQESKNPFDETLERVERLKTKRDFERKRQSFLESTEAVEKSEEEVLRMFDLIKQRLHQLREKGVNFGTEEDPNQPSFVFRSNGFSCSFYWVIAYSNSTSDAKLWVKYWKGHFTSNNQAIFYPGNEPQENKAQTFALDVDEDFNFIWRINTSKLKTEEIVNDAFNWIFDRIGEKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB2</accession>
    <name>A0A654DYB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13766" checksum="5AA1A97599F278E1" modified="2020-04-22" version="1">MKKYFTVKNILLVISILLNIVLTGILGIRAMNEPTHKRGILTENIKVGLFSNPNVLFELPKGLTVEDASPRGIAAIDMFELERFSIVITSDLGNLVNYDADPSELQPFGNHYSADYPTMEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE6</accession>
    <name>A0A654DYE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="303" mass="35358" checksum="5560038C4667D882" modified="2020-04-22" version="1">MSNLFQLIKTYSPANIAREVYYSYLRSKDHAAGVGEFYNKHHQDFLEVYGELIQAFRTSDIDEILDYELEAMQISPEMKVLDAGCGVGRPALHFAQKSGAQIEAISISQRQIDYANNLKGKFNTGNVTFTKLDYHRIQEYFGNSQFDRIYFLESFGHSTKKKELLKSVWDALKPGGEVYIKDLFCRVTDSRKDQKVINREIAKINQQYHYEISNLTQFLDMARKMGFVLKLVKTIDIKLEAFENLAISNKFQELTGIYKIESFDGYIFPVDFLEVKLYKPAFNMEEAKDRYFLQNLFYKNIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ6</accession>
    <name>A0A654DYQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15757" checksum="E94048810E617C3F" modified="2020-04-22" version="1">MPMTTGYSGTPLFKKLGIRQGDRCYLHQVPDDYFDLLFGLPEAEFEDGKVDGEYDFIHAFVSYQSELKSIWSPLKAALKKDGMFWISWPKGSSKLPKDINENDIRAHGLENGLVDVKVCAVDKDWSGLKFMYRRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS3</accession>
    <name>A0A654DYS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_12105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="408"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="633" mass="71319" checksum="CA74F287E22F7400" modified="2020-04-22" version="1">MMNREGYHILLATFLSLLPFLGIGQDQSVADSLIEVADRFPRQDTARLRILTLIANNQTDPQKKLKFADLLMEEAREIQDLKFLHHAYLNQGQAYRLMGDFDVAIYSLFKALDYAEKSGYIKGEAGANTALADVYSILGNHNNSLLYYKEALGQLTSQDSVLLATILLNMGDEYYMSNMYDSALVCFQESKRIYERMGGDRSGLAYNLGNIGLVQAQQGDLEQAERNVRASIRELEKLEDHYGSAIFLTYMAEIYQRKGLLRDAKEFADSSMSISRRYGLKAEIRDNSLRLADIYAMSADYESAYRYHQEYVALKDSISNDEIYNRIENLEGAFELAKKQAEVDLLKAEQKNHQIIVTTATLIAIILTILAYVSFSYYRSKARINVVLEEQKRVLETLNETKDKFFSIISHDLRGPINSFHGISSLIKYFVASREPDQLLEVADDIDKSVDELSNLLDNLLSWAMKQQGQFSYAPEALNLKEMAEELVATLGNMARGKGIALSADIDPDISLWADRNTTMTILRNLVNNALKFTPRGGKVELTAKVKDQMVEIRVVDTGVGMTEEKVENIFMLEDDKSTYGTAGEKGLGLGLQLVHEFIEVNNGRIYVQSQENVGTEFVVELPASVQTESVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ05</accession>
    <name>A0A654DZ05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12775" checksum="D5A82D0D55EEE1AB" modified="2020-04-22" version="1">MRLKAYTIIEGIVSMVLLSILLSIAVIVSFNLYRSFPARRELALKNQVTQQLDSLVAIKQTRPLTFSKDHLSLSYEVRDFQGFDLIKIASCMGQDSTGLKEQASTIFYVPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ39</accession>
    <name>A0A654DZ39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14251">
        <property type="entry name" value="PL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039513">
        <property type="entry name" value="PL-6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14592">
        <property type="entry name" value="Chondroitinas_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="786" mass="87302" checksum="C401E96095D65327" modified="2020-04-22" version="1">MIKLSIKIDPINIKMMKSILFSLTTICLLMSCQLKEANEGILVSNAKELQDAISKAQPGTSIVMANGQWENVEIRLVAKGTEDQPITLRAETPGEVIIQGQSDLKLGGEYLVVDGLYFTNGASPSESVIQFFINKDTLANNSRVTNCVIKDFNKAQRNMTDLWVLFKGKYNQLDHCYLEGKSNRGPTIRVDLEGNESIRNYHKINDNYFGPRPPKGGPSAETIQIGNSSTSMTPSYTLVVNNLFDRCNGEVEVISSKSNFNEFRGNVFYKSQGSLVTRHGNYCIVDGNYFIGDEDSPQVGGVRLIGTGHRVTNNYFYNLHGEIFRGPLAMMNGIRQPAVNRYFQVTDVVVAYNTWVNCSSPWQFGVGSNVDQKEVLPRSEIRSETPIRTLVVNNVIYNSEGDEMPIIRYDSIDGIDFKSNVINNQGVAFRGVNGLEKRDFSMRELEENIWIPTSDLSEIQAYYGFEFDQIDKDLFGNSRSESSSIGATNGAGPEKPNIMDVSKYGPDWYNPSADDSAKETHTVSTAADFAKAMKSAQDGDIIELASERFEFNYSMVIDKKLTIKSAQPDSKVSLVYAGPAATPAFEMNPKGKLTLNAIILSGNGENYAFATLKENMSGLYNLKVKDCELSDFDYVLKAYKYSFSEYISFESSLIKNCNNGIELSAEDDDRGEYNAENVYIVDCQFDRVNKNVIDYYRGGYDESTVGGNLLVRGSTFTQCGASEENGILINTYGIINVDISGNKFQNNPVEQVARLWGAKNNSHADNVIANSGALVVEENLPLKLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ50</accession>
    <name>A0A654DZ50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">murD</name>
        <name evidence="17" type="ORF">MARINOS108_110112</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="110"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="314"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD15955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="458" mass="50161" checksum="CA7BBD40F1799079" modified="2020-04-22" version="1">MSKSIAILGAGESGIGAAILGLKHGYRVFLSDAGAISADRKLVLQSYGIAFEEGGHSEDIILASDEVIKSPGIPDKVPMIQALVAKGIPVISEIEFAYRYIPQTAKVIAITGTNGKTTTTLLTYHILKSAGLKVALGGNVGVSLAKLVAEGDYDYYVVEVSSFQLDGIVKFKPNVAVLLNITPDHLDRYDYDFQKYVASKFRITENLSHEESFIYCADSEPVTEEVAKRKIEACLFAISATKSPKWEAYMDDEHLIFNYRFKEKDKKHTIPVSEISLIGKHNMINSMSAVLSALTMEVSIEQILKGLKTFVNAPHRLEFCGEIDGVRFINDSKATNVDAVYYALEGIRQPIVWIAGGIDKGNEYDQIAALVADKVKGLICLGVDNSKLTGRFGSTVETRETRSVEEAVNLGYEMAASGDVVLLSPACASFDLFKNYEDRGDQFRVAVKNLKETKRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD8</accession>
    <name>A0A654DZD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024967405" evidence="2">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7381" checksum="447D7B8608719CF1" modified="2020-04-22" version="1">MVRKILLSVILFCAFMMAKAQETVAEAPESGDYFSDQIKFYMVAFIFALSIFFTVRTFRNKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH4</accession>
    <name>A0A654DZH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024905001" evidence="1">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21181" checksum="D2A2CED037D91E4E" modified="2020-04-22" version="1">MNKFLLVLGFLLVLAACGQRIFPSDDGELQKVTTKAGDDFLEFRLTRTKVNPDPNREYFWFKSGQLQSTRGSFSGYLLDGEFTRMNQEGQLSARGEFKDGLKTGTWYSYQQGELVTIETYRKGQLSGKSQDFLGGEVVEERIYKSGVLNGFRKELRGDSVRQIKYRGGVPTDTTYLKSGVLSLDFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ4</accession>
    <name>A0A654DZJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="78" mass="8925" checksum="ABBF0E55B1F21589" modified="2020-04-22" version="1">MEATTAREKHNEKEVVFVRNRDGAMVRLQVPGEGVTVKVYRVSVAFKFGQVQYIDALHDWGGCLFCANIGNFRLIDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK7</accession>
    <name>A0A654DZK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="520" mass="60273" checksum="032953D23E640457" modified="2020-04-22" version="1">MVGRIMFFTLFTLTSLQGMTLGDSLISVSQVSFSSDLEKSIFERLSENESDYFPGLLLFSGADEGQKEQWRKSYEAKIKELRLIKKPKKNEKYVKKVYEFVHDEFLRKYEAIAYFHQIFQNGVYNCVSACALYALVFEDLGIPFTVKETPTHVYIVAYPESEQIGIETTDPIGGFKTFSLGFREAFVGQLADLKLIDRSELNADVNVVFNKYYFTDSDLGAKELIGIQYYNHGISNLQEQKYYEAFLDFQKAYILHPTEQIGELVVSCGILAITTVDYNEWADVELLGFISTMNHPSVGNAEVLGEFSRLLNNQLIKRNDTQFVARAYRLIREKARNDELKSDLDFYYNYENGRKLYNKGSYKKSFPYVLEAFAANPSNQDAENLLVSNINNATVAHSFSSDEILELLEQLYADYPELNSNAHLGSLRMNLYLEAMRDAYIKSEVEKAKMYKKRFEENVEQYKYSYYEHNVGKAYSQGVSYYFKKGWYQSARQVLNEGLKFAPHNQELKMRKYWLDRAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT1</accession>
    <name>A0A654DZT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="54" mass="5955" checksum="DE802B936730EF8D" modified="2020-04-22" version="1">MAVMSASIKKAVNPTFGQSAVHLNFVSKIRFASKACYLSICVRSLYHFLPHRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV8</accession>
    <name>A0A654DZV8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ORF">MARINOS108_110071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD15908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="24315" checksum="CBC02A8C9D6EE93B" modified="2020-04-22" version="1">MHKITIAIDGFSGTGKSSTAKKVAGELGYTYIDSGAMYRATTLYFLEQDVSLDDASQVEHALDTLDIRFEEGHVLLNGLDVSNEIRTMRVNEHVSAVSTIAVVRHAMVAQQQKIGKGKGIVMDGRDIGTVVFPGAELKVFMTADTRIRAERRQSELAEKGIIEELNVIENNLSQRDEIDSTRSESPLRKAEDAVEIDTSNLTFADQVHKIVSLAKEKIHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX0</accession>
    <name>A0A654DZX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S protein maturation auxiliary factor YitW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yitW</name>
        <name evidence="2" type="ORF">MARINOS108_110036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12501" checksum="BB3002A8E24ED5F8" modified="2020-04-22" version="1">MEDNKTQIADDLSLKESVVRAIKEVYDPEIPVDVYELGLIYEINIFPINNIHVLMTLTSPACPSAEEIPGEIERQIKALPEVNDVTVEVTFDPPYTTEMMSETAKLELGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E010</accession>
    <name>A0A654E010_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="157"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="31780" checksum="605CE5A2B070CD2D" modified="2020-04-22" version="1">MLYKTKDQRTMKTIIVATDFSAAANNALGYAAKLASAVDADLVLFNAYHMSTHAINGMVGPEVLDRLVRNNEKQLQDLSDETAQKYNIPVSWVSKTDDTIEGLNHYVKDRHPDLVVIGMESNVFSYELLGNTTTAAIKHLKTPILVVPRMATFSSIEKILYAYEPSYLGQHNQLDLMKEIARKFRAQLEVFHVDTHPKKDHPENEENLIHAANTILKDIPHTYSTVSNETIAEGIAQEVDHYNADLLVMVPHKTGFLASLFKGSNTRRVSLKTKVPLLVIPNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E021</accession>
    <name>A0A654E021_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="19042" checksum="41117D91D6EE5743" modified="2020-04-22" version="1">MTFSIRRGSGIITLSLACCPDLGMTFSQQNVFGHCHSELRRRVRQCRHPISFYTDKPTFYVDLYGMIYTVYILRCADGTYYTGVTNDLDRRVWEHQSGHDSRAYTFRRRPLKLVFQEHFPDVNQAIAFEKQVKGWRRAKKEALIARRWDLLPELSIAYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E038</accession>
    <name>A0A654E038_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">MARINOS108_110106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="211"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD15949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="527" mass="58102" checksum="75EF95A70EC69DA5" modified="2020-04-22" version="1">MAENMYQFDLPSHHKSIIKVIGVGGGGSNAVNHMYNLGIKDVEFVVCNTDIQALESSPVPNKLQLGVNLTAGLGAGANPEKGKHAALESTEDIREMLSEDTKMVFITAGMGGGTGTGAAPVIAQIAKEMDILTVGIVTAPFMFEGRKKIQAANDGIAELKANCDTVLVILNDKLREIFGNLPIREAFGQADNVLTTAAKGIAEIITVPGYVNVDFEDVKTVMKNAGAAVMGSAQTHGENRGRRAAEEALNSPLLNNQNVNGADKILLSIMSGEDAELQMDELADITDYMQEFAGEDAEVIFGHGVDADLGMNIRVTVIATGFGGVQEIQPIARKQNTTPAPDSKRVYDLESSRQIKLFDSAKDDEEDEDDFEEKKETPKRDSFTYDFLKDEIKKAVEEEDELDDNDFEFDLGGGYEVFDESDEEEEDEKEADDDFFSIESLERNHSPSKKLELMEQRRKREQMLEGTSKEDLSTQNFKEKFDVPAYERKKVTFAKVPHSSERNISKFNLTDDNQILGNNKYLHDNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C5</accession>
    <name>A0A654E0C5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase synthesis transcriptional regulatory protein PhoP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoP</name>
        <name evidence="6" type="ORF">MARINOS108_120339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="26474" checksum="6E35B012DFB09A67" modified="2020-04-22" version="1">MAKILVVEDEPNLRIGLKDNLEYEQFEVVLARDGVEALHHLDGDLFDLILLDVMMPKMSGFDVCKTARKNGVVTPIIFLTAKGEEIDKVLGLELGADDYITKPFSIRELIARVKAVLRRAPGAVSPEKEAIPEQLQIGCLTVDFTHYEARHTTQGQMKMSHKEYEVLLYLYQHKNEIVSRYQLLEDVWGYDTQPTTRTVDNFILKLRQKIELNPNDPKHILTVHGAGYKMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D1</accession>
    <name>A0A654E0D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18452" checksum="7DDFBFCF121B0187" modified="2020-04-22" version="1">MSFKSIFFTLFFTCSGIIVFSQGVALSEDEVPPHIVARHYADHQGSLAVGWQQIEMEGANRYMATYAEDKIRRETIYNKSGRPLFESTIHEGDLPLMMSYYVEDRFGKFRVVEFKSTKDLSNEIMRYTLVVKAKEYGELELAFDNEMNPIESRTALASYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D2</accession>
    <name>A0A654E0D2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="22805" checksum="7FEA43F5ECFD75A5" modified="2020-04-22" version="1">MIGFEMAKKESESLHVLSTQEWRDWLQQNHTKKQSVWLIQYKKNSDMPSVSWSEAVDEALCFGWIDSTRRPIDEEKYMQYFGKRKANSTWSKVNKEKVEKLIADGRMTSAGLESIKIAKQNGSWSILDTVEALIIPDDLEVAFKTTPGSKDFFLSLSKSAKKNILAWLVLAKRPETRLQRIKETVESAGRKLKPKPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E8</accession>
    <name>A0A654E0E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024653">
        <property type="entry name" value="Peptidase_M10/M27/M57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12388">
        <property type="entry name" value="Peptidase_M57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025040212" evidence="1">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="267" mass="29370" checksum="7D8BB39BD69F8EAD" modified="2020-04-22" version="1">MKNYLKISAYALLLFLLASCQDQNTPEQPQLEDVPNEILDKVDALGFNANEVRMYDGTLFIEGDIAIPVSKLDQMKPGQRIPTEEQYSTDNLVAGNPRTINVFVDMPQKYKDATDIANARYNAESLNLTFQRVTSSSGADITIKASPWYYRFLGILGSAGFPENGNPYHTILMTRAYYDNVSNINGLATTIAHEMGHCIGMRHTDYMDRSYSCGGVPDNEGDGGVGANHIPGTPTGPDANSWMLACGTPEGDRPFTSNDQVALDYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G7</accession>
    <name>A0A654E0G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="24237" checksum="AC93D39F28318F96" modified="2020-04-22" version="1">MKTKIIGIALIVLLGSCNTKVKKENENLKAETLKLKQENETFQSQNKKLNASIEGYKVFLKEVDENLKSIDANATMVGKVGKDGKGNADTKEMIRARIASIKALMDNSKLKLIALDRSLNEMRKKYGDQSEEVLALNNEIKAQARILLEREAEFVVLKSELEADVEELELAYEKQLALTQELNNILNRAYYFAGSSKDLKQKGIVDKEVDSSALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K4</accession>
    <name>A0A654E0K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="545" mass="61938" checksum="347F165432640723" modified="2020-04-22" version="1">MTEYNKWFHPYKPDKKYSKKVAYFSMEFAIDQALKIYSGGLGFLAGSHMRSAYELRQNMIGIGMLWKYGYYDQSRAVDGSLEVKSIEKYYPYLEDTGIQVKIQVLDNANVHVRAYVLKPETFGTVPMYFLSTDVPENDHLSRTITDRLYDANDLTRISQSIVLGIGGAKVVEELGGADVYHLNEGHGLPAFYYLKDKGYTREHFAFTTHTPEKAGNEERSGDFLNKMGFFGRHLSAEELETQTVNDGMLSYTVAALRLANRSNAVSKLHAKVSQDMWKGYEGISEIIPITNAQNQKYWQDEALAAAAESGDKVAFVNRKKELKTQLFKEVADQTGKLFDPEVLTIVWARRFAGYKRADLLLSDEARFEKMLSNTKKPIQVIWAGKPYPKDQDAIDTFNRLHFFSKYRSNVAVLVGYELELSRLLKLGSDIWLNNPRVTREASGTSGMTAAMNGSVNLSTYDGWIPEFAKDGKNSFVIPPADLKLDMEGQDQQDQESLYHILESRVIPTYYGKPDTWHDIVVNGMKDVLPEFGSNRMAAQYFKELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q2</accession>
    <name>A0A654E0Q2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="28440" checksum="85973C97FBF1B75B" modified="2020-04-22" version="1">MHKYFAKPLFLGKMLEFLPECHSTNEELLLRIRRETLNEGHVLHTGHQIAGKGQRGNAWLSERGKNLLFSIYLTPKVLLPKQAYLLNIISGLAVVDALVPRVSDKVELKWPNDVYVGDKKISGILVETMIEGGVIADAVVGIGVNVNQSHFPLATATSILMESGVTCELEELLEQIIQQLEKYYLKLKSGDTRGLLGAYYKLMRWRGEIHSFRDKEGIFEGEIIGIDDTGRLTVKTNNIVRRFDVKEIAFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E114</accession>
    <name>A0A654E114_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsfS</name>
        <name evidence="3" type="ORF">MARINOS108_120527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14410" checksum="0853A0A48DA46F70" modified="2020-04-22" version="1">MQVKTKEAINSSKLSELVAQGMVEKKASDVVVMDLREVKNAVADYFIICSGNSDTQIDAIADSIEDEVFKHSTQNPWKREGKESREWIIIDYVDVVAHVFNKEKRKFYGLEELWGDAKVTQIDKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E136</accession>
    <name>A0A654E136_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">MARINOS108_140113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="38913" checksum="E422D1DB2D250E29" modified="2020-04-22" version="1">MSQEKTASFPKFLKSSLLLVVFGLLIIQTGYAKDPVEGEAFDPSEMINHHIMDSHSWEIFHGLSLHLPVIIYSEEKGLDIFSSSNFYNEEHEVVPFNGYVMEHEHIALESGAHVLDFSITKNVFFLFINALVMIMIFMAVARGYKKNAGRAPRGIQSFFEPIIIYVRDEIVKPNIGPKYERYLPYLLTLFFFIWFGNLLGLLPAAANLTGNIAVTLILAVASLVITLASGRKTYWMHILDPLGNSMGWLAKFPLYLILWPIEIIGIFTKPFSLMVRLFANITAGHIIILSILSLTFIAQSFAVGVAATLFAAVMNLLELFVALLQAYVFTLLSSMYFGQAVEEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E198</accession>
    <name>A0A654E198_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="542" mass="61547" checksum="51CDC429E850B3BF" modified="2020-04-22" version="1">MPKIISFNAKRILIILGILVLLSGIAFLVEAIAKRELPKLLGEQVTYESVTLSILNGEITFTKPRVQVDSAENHANLNIRSEARQISIHGFSLWNLLLSQKIKVKKLNIDSLLLGIVLPTLQASKTEKKEINLFVRDLFNRIEVEHFEISSGTLVVQKKGSYDTLLAMKKIHLSAFGVFVDTSTVHNIFPLDFDQSETKVSKLYVKAGEDYTLSADNLHILDTSFSIENIHLKPVDSRSSFVQKHPYEKVRVELLAQKLSAEKLLWDFMEDRTLKVRAESTLLEALQINVFKDKTPPAPQPETKPLLAGLLRDLPFIFTLDTLRLRNSYIQYEQLPVVFPRAGKLYFDKVYMSGYHLTNDPEEIQKEPITILDIQSDFMGKGALKTTILLDMGSNRQEFSVSGTLGAMPITFINQTLAPLTGVEASGQLHGMAFDFRGDEYSAKGKMIMEYSDLKVKVYDQNRDKVWLKSIFGNMILNSNNHPDDTMGYQEGEIYFVRYQNKGFFNMLWNSLRVALMDVTMPFYTNPDYSTTTAAPKYLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G0</accession>
    <name>A0A654E1G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">dacA</name>
        <name evidence="13" type="ORF">MARINOS108_20015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="12">
        <location>
            <begin position="84"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="34920" checksum="E76889BF555365E9" modified="2020-04-22" version="1">MILGFYIGFLEIGWVDIIDIFLFAILLYQVYKLMKGSVAIKVFLGFLVLYLIYLMVKAAEMELISNVLGQFMGVGVLAAIILFQQEIRKFLLLLGRTSIFNEGNLFDNFKSIWSSKGNYQKADVTPLIEAAKTLGGTNTGALIVISKNSELKFFAESGDRLDAVISKRLLMAIFNKYSPLHDGAVIIYNNKIIAARCILPVTEREVPAQFGLRHRAGIGMSENTDALVVAVSEETGQISTMRNGEIFHNLSTQELRKTINEYLYEDAKETTSSESVLKKAKQEGSTKKEEPKKKEDSKKEEPKPPVKESAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K2</accession>
    <name>A0A654E1K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024927993" evidence="2">
        <location>
            <begin position="25"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="368" mass="40371" checksum="9B9AD7265718BAB7" modified="2020-04-22" version="1">MNKLINQQLLFLSLSLLLVGGAAAQLTTPRPSPAAELNQTIALTTITVNYSRPSVIRGNNDRTGQIWGSQVPWGLAPNAFGNQKPMPWRAGANENTTISFSTPVLIEGEQLGAGTYGLHMIPEESGTVTIIFSKNTSSWGSFWYEQTEDALRVKVQMKEAPFTNVLTYQFTEVGLTSGTLALMWEKKQIPIKLAVSQETILAKFRDDLRGVQGFGWQGPLSAANYCLQNNINHEEAVKWADQAIAANRTGQTLGMKAALLFQKGDIEAGVKTADEAKEIATMNELNTLGYQLAGANQYEKAEEFFKLNIKRNPKVANGYDSLGECYVAMGKNDEAIKLFKKSLSMDPPPNVKLNSIANLKRLGVDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X4</accession>
    <name>A0A654E1X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="4">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="249"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="48221" checksum="43ECC37817C09DB8" modified="2020-04-22" version="1">MTILMLGWEFPPKISGGLGVASQGLSEAMAKAGHKVTFLLPKKTKNQVSKLVKLVDASALTPDLDYWKEKKTYEQIIKDVEMGERVLPYLPAQAFQQVKETKVKKVVLEPTEESELLERIRLTGEYEGQLNDELIKYAMLSVQVAIKEKPKMIHAHDWITFRAGRMIKSLLKKKLCLHVHSTEYDRNGSYAQPFILEEEQLGFQACDHIFCVSEKLKNTIIAQYGIAARKITVAPNALTLSAPEHPVKRTPMNIAFVGRLTPQKSPITFLDIARELTSLGYDFHYFIMGDGYLRAELEEKVQSSNFSDRVTFTGFLERTRLLQKLNEMDLLVMPSASEPFGLVALEAIMKKIPVAAATGSGVGEFIPSMPQVDRWDHYSYNKLIVRLMTEDQYRQEITENCLKEALKLTWENTVKRIEKGYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y5</accession>
    <name>A0A654E1Y5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="33659" checksum="F2D85FC95F7FE150" modified="2020-04-22" version="1">MDSLPLVSIICLCYNQKAFVGPAIRSALAQTYQNLEIIVVDDGSTDGSKEEISAIIKDTSIQFIDLPKNIGNCAAFNVGYRASKGEYLIDLAADDLLLPTRVELGINDFTNGPAQAGVHFSDAFITDESGNVLNTHYPRNQDGGMRAKIPSGNVYENLIRKYFICPPSMMTRRKVFDDLGGYDENLSYEDFDFWIRSGRTYEYLFNPAPLVKKRVVKNSLSTRQFGFRSRHLASTYQVCEKIFNLNQSVSEDKALIRRCRYEIKQCVKTFNFELILKYGKLIGQTQRRLSSLSSMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E213</accession>
    <name>A0A654E213_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024822479" evidence="3">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="460" mass="53244" checksum="CCC5221593B79E3E" modified="2020-04-22" version="1">MRLILFCLLTWLISCPLAAQEGGRDPELDSVERVLMERWQRAEQGRKIFERMYAEDPRAAVDSANVAIRRAHQTEGQEKLLAYQANTRIDTLVEIDLSYAGLDRIPEFVFEATKLKVLIIDHNDIRKLPKELGKLQHLERVYWRANHLERFLWVRIQRIPNLKKLDLSNNLLERLPNGIRKLEGMNELVLDQNFFREVPIGRLSKVSFLNQVSFNKSHALMLSDGKYEKLSFLEVFKANNSRLTAIDPAFYNMQGLKELQLQENELSSLPPGISRMRKLEKLSLYKNKLQSLPEDFYELDLKVIDLYYNELEMIPEELGAFKNLEVLFLANNRIYSLPESIGKLSNLTEMYVHHNRLSVLPESVSDLKKLTVARVNDNYLVDFPSQFLEMEDLNDLDVSNNQITTIPDEVEALPSLRLFTFQENPIAIDGQANAHLAPMIVRMMEAGVICVPRIYAQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F0</accession>
    <name>A0A654E2F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="435" mass="49640" checksum="72E2FEBDB13DC393" modified="2020-04-22" version="1">MRQKLLREGANELSYEIRGIVKKAEQLEQLGYSILWENIGDPIQKNHKLPAWMKEIIAGLLYEDNTYGYSHSKGVLSTREFLADLNNKRGGAQILPQDITFFNGLGDAIQKIYQYLLPTSRVIGPSPAYSTHSSAEAGHANHHPITYKLDPDNSWYPDMDDLYNKVKYNPSIVGILIINPDNPTGMVYPKEILEKMVAIAREFDLFLICDEIYMNIVYNGAKTCTLAEVIGDVPAISLKGISKEFPWPGARCGWAEYYNRTNDPEFTRLCETIDNAKMIEVSSTKLPQLSIPRIMKDPRYPEFIKETRDKIGRRSAYLNEVFSDVPYVKFNQTNGAFYNTMIFEPGVLNDKQTLKITDPKVEALLESWMKANHMTLDKRFVYYLLAAKNVCIVPISSFSSDLLGFRLTLLEEDESIIEKTFKLIKEGVMEYCQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F8</accession>
    <name>A0A654E2F8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="3">1.8.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="18139" checksum="28EA6DDE6CF9E906" modified="2020-04-22" version="1">MTLGLGGGCHWCTEAIFARLSGVSSVVQGWISSVAPHETFSEAIKLQFDHERIPLEVIIHIHLLTHSSTSRHTMRHKYRSAIYTVNESDAQAARDSLTILQSHFQQPLITQILPLDVFRLNSEQYLDYYFKNPEKPFCKTYIDPKISQITREFSSYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y4</accession>
    <name>A0A654E2Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="8030" checksum="7C88922DCAB451E5" modified="2020-04-22" version="1">MRDWQCVYRDSLEYRAEIVKAVLEDQEMSPVVLNKKDSAYQFGTFEVLVAPEYIIKAIKIINDEIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z1</accession>
    <name>A0A654E2Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13016" checksum="479735404019B92A" modified="2020-04-22" version="1">MLVVLIFHEGHHFTELSSKGIDFSNHPVESLAGIVWSFITGDYDEHSPAEPLTDNSPEQNEESQEESSEQDETKKLFESGAEGILGGLQMIKDKDYYHILELTNHPRQIPTPPPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E356</accession>
    <name>A0A654E356_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="94" mass="10457" checksum="C4CE3A7364645183" modified="2020-04-22" version="1">MTYLVIGRDHKDGFERRQQNRAAHLEGAKKLKEEGKLLYAVAILENGKMAGSVMVMNFDSEAELNDWKANEPYLTGNVWGSVEITEGAVAPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D1</accession>
    <name>A0A654E3D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021868">
        <property type="entry name" value="Alpha_2_Macroglob_MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041203">
        <property type="entry name" value="Bact_A2M_MG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041462">
        <property type="entry name" value="Bact_A2M_MG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11974">
        <property type="entry name" value="bMG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17972">
        <property type="entry name" value="bMG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17962">
        <property type="entry name" value="bMG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025069169" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_N_2" evidence="4">
        <location>
            <begin position="968"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="5">
        <location>
            <begin position="1174"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1832" mass="202882" checksum="85E3637514E72AAE" modified="2020-04-22" version="1">MKIKHIPLLTLLCLLFACGGDNSGSSGTIINDARFGEYISGYTSGTISQKDNINVQFTNLVPIPDAPQLSTLFSISPSIKGTLVKTGPHAITISPETPLKSGQKFVFTLNLQSLIEVPKELGQFKFEISIIEQNFEVILGEMLAPDPSTPDQLQFEGTVNTADFAENEAVEKMIQMEGSLPIAWQHRSGTSHRFAVTGITRTKDPKTIQIKASGAPIGVKRSEDLRIEVPSQAVFSMISTKVDNSGDPFVAIYFSDPLDPSQSLAGLINLEGVRNPGMVIEGNQVKVYVPQNMTGSKKLEIFEGIKNSKGQALGKTTTSYIPFEPEKPQLRLVGNGTILPSTSGLVLPFESVNLKAVQVEVVKIFEANMPAFFQVNNLSGEDQINRVGRKIMRRKIDLSAKAEDLSSWNRFTLDLSTLFEAERGALYQVRIGFLPEYTNYPCDQVFEVQDNPTDKESWSIHQDDNFYEWGNLWDYRYPEGYTWKERDNPCHVSYYNSNRFVSTSLLATDIGLIAKIGGDNTMKVIATNMTNAQPIQATIKVLDYQLQEMSSSMTDAQGFATIKPERRPFLIIAEAQGQKSYLRLEDNESLSLSNFDVSGTRVIGNIKGMVYGERGVWRPGDDIFLSFMLEDPEKQIPDNHPVVMELRDPRGNIKDKQVVTQGVKGLYTFQTKTSPDDVTGNWWTTVSVGNNSFAKTVKVETVKPNRLKINLDLGGDQITYENRAVKGKLNVKWLTGLTGSNLKAETELRLVETNTTFNGYAQYEFDDAGKNFHDDPKQIFSGEVDQNGDATINLQLPSKPNSPGALKAIFNTKVFEPGAAFSVNSKAVTYLPYSSFVGVNLSTADQGSRIERDKPQQVDLITLGANGQPVDRTGVEVKIYKLNWRWWWDQSDDYSTNYVSSSYAELMESKKINTTAGKGKINFTIKSPNWGRFIVVARDPVSGHSSSQVFYTSWYGSSGGNAIGATSLEVSTDKAEYAVGEKINVTMRGSYEGQALISIENGSSVVQNFWVKTEKEWTSFTVDATPEMAPNVYLHASLLQPHGQTSNDLPIRLYGIASIQVYDKETRLEPTIRMANELAPNEPVEITVTEKNGKPMAYTLAVVDDGLLDLTNFKTPAPWDHFYSKEAIGVKTWDLYNDVIGAYGGRLERLLAIGGGEGGLDDSKKKEENRFKPVVQFMGPFYLEGGQSKKHTFTMPQYIGSVRTMVVAGLGGAYGSAEKSTPVIKPLMVLGTLPRVVGPGELVSLPVNVFKYKEDIKNATITVETSGVLSLRGSNKQTIELRESNGTLYFDLAVAEKLGPGKVTITASSGSESARHDINIESRSPNSAQTIVKVLPVEAGQAVTPGGKLFGMEGTNKVTLEVASIPPINLEHRLSYLIRYPHGCIEQTVSSVFPQLFLKNITELTVEEQVKIENNIKTAIKRLSKFQVPTGGLGYWPGYDNPNSWGTSYAYHFLIESQKQGYSVPGELIEKILSYQRNKARNWSKSVDHRDSDLIQAYRLFTLALAGYPEIGAMNRLRNTSDKSVQSVHKLAAAYAIIGQKEAAQTLMKDYGRSKVKDYGYSYYYYSYGSFERDLALLLETYVYMDSKAEAYKILQEISERLSADGWMSTQTTAYSLLAISKYITANQTEKGMKAGISYGGKNTTWSSDKAIYKSELPIDAIQSLKIDNKGESNFFVTLSITGTPKPGDEPVAQSDLAVSVRYLDPSGRSLSPDSLKLGQSFDVLITVKNEYAAGSVKDIALTHILPSGWEIQNDRLTDQETSEYSAFDYQDIRDDRVYTYFDLSRDSQKVFKVSVTAAYPGKYYMPGIQAEAMYKASISAKTAGKWVYITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M7</accession>
    <name>A0A654E3M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025069749" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="18275" checksum="B4336B92193FFD08" modified="2020-04-22" version="1">MRHLNTIQMKKLLICLAMILGTTLWTYAQSDDTEMINLSKQKWAWMADKNVEELASLFHEESKFVHMSGSWKKDRELEIIESGSIWYKNTIVHDVDVKRFGNTVIVWSRITLEAHVRGNDVSNEFTATEVYQKQSDSWQLLDLTFSSVRDTHQIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q9</accession>
    <name>A0A654E3Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7468" checksum="60814082E75CDDB9" modified="2020-04-22" version="1">MEDNFRPPNYYVYILHSFKLVLSYTIDFPECPISKLFENILKSWDTVPYIIFSRPSGRLFSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R0</accession>
    <name>A0A654E3R0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ileS</name>
        <name evidence="11" type="ORF">MARINOS108_20486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="752"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="665"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127425" checksum="3EA2BFF8C4E1C811" modified="2020-04-22" version="1">MAKYPEYKQVNYPKVAEEILKFWEDHEIFEKSVTEREGAPTFTFYEGPPSANGTPGIHHVMARAVKDIFCRYKTQKGFQVKRKGGWDTHGLPVELQVEKELGIKKDDIGKTISVADYNQKCKEAVMKFKDEWDRLTMQMGYWVDLDDPYITFDQKYMESLWHILKKLYDKGLVYKGYTVQPYSPAAGTGLSSHELNQPGTYKDVKDTSVVGQFKVKKDDRSAFLFSAADEDVRMLAWTTTPWTLPSNCALAVGEKITYVKVKTFNQYTYAPVSVVLAKALVGKYFSDKAKDIKLEDYKAGDKLIPFEITQEFSGKDILEVRYEQLMPYVTNEDLEKNAFRVIAGDFVSTEDGTGIVHTASVFGADDFRVAQQNNVPAILIKDETGQDVPLVNKKGQFVDQVTDFAGYYVKEEYYDDEVRNAPDFKPTDVLIAIKLKEENKAFKVEKYEHSYPHCWRTDKPVLYYPLDSWFIKTTAMKDRLVELNKTINWKPASTGSGRFGNWLENLVDWNLSRSRFWGTPLPIWVTKDRKEEICIGSIAELQAEVKKSIAAGYMKEEVGDDFDLHRPYVDDVVLVSASGQPMYRESDLIDVWFDSGAMPYAQWHYPFENQDTFDANYPADFIAEGVDQTRGWFFTLHAISTLLNDKVAFKNVIANGLVLDKNGNKMSKRLGNAVNPFETMDKYGPDATRWYMIANANPWDNLKFDIEGVAEVQRKFFGTLTNTYSFFALYANLDGFDFSKPALPMDQRTESDRWVISRLNSLIAEADAAFNDYEPTKAARAIQNFVTDDLSNWYVRLNRKRFWVGEYNADKEAAYQTLYTALMTVAKLSAPIAPFYAEHLFQDLNKVSGLDTSASVHLANFPVSDTELIDEELEKRMHLAQSASSLVHSLRKKEKIKVRQPLHKILIPILNEADKDRIAQVAALIISETNVKEVEYVDDASGILVKKIKPNFRKLGQHFGPKMKLLTPLINQMDQAQIKELEQTGEYAVELEGEKVVLGLEDVEITSEDIPGWLVASEDGLTVALDITITDELKKEGLSRDVVNRLQNLRKDQGLEVQDKINVSYHTNDESLKSAVEAFKSYIQKETQALSLEYVNEANGGTLLDIDGLELTVAIEIAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S3</accession>
    <name>A0A654E3S3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024544">
        <property type="entry name" value="DUF3858"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12970">
        <property type="entry name" value="DUF3858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025038338" evidence="1">
        <location>
            <begin position="19"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="2">
        <location>
            <begin position="53"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3858" evidence="3">
        <location>
            <begin position="533"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="630" mass="72564" checksum="B8B7144F8FEC10D7" modified="2020-04-22" version="1">MKLSFVILSFFLFNIGVAQGLLDDVPADLKTNANEIVLYDHTTFTIKDLTSSSLHRKYRAIIRNSRATDLKSVFLYYDDFRAIKSAQIKIYDIYEHEREHIKLKDFGDYSTKGSSIADDSRTKYYEVTDDKYPYIVEVEYTIDYMGSMFYPTWYPQSDEYQSVLHATLHIESPESNPFRHKSVNVSAQESYEQGQLVFDWAVDSLPAFEFEPYSYTLEDYAPVVYTAPNRFEMDGHVGNLSTWSDFGEWIRALNKDQNTLTFEQLGEIKKLIPEGASDLEKVKIAYKYLQDNTRYVSIQLGIGGWQPFESGFVHSSKYGDCKALSFYTQSILSGLGVKSYYTLINAGPYAREVDPEFPNARFNHAILTVPFESDTIWLECTSQTDPFGYQGIFTSNRNALMVTEDDAVIVKTKSYSPKENLQITLAELSINIDGSADVKINRTYTGLEIGNDRFESSVLTPPSEQSKWFYDRHKWGDLVLDSLNLSPPTNQVVPTAQMNANLQLKKAAISNSNRLFYQPFVFTNVNHMNFKTKERQKPVEIRYGYTQIDTLNVTFPEVYFPENTPQDIQVKTSFGSYDRMIIQDRNQFMIIRKFVIQSGTYPPSSYESLREFIRGVQKLDKEKIVMLNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E447</accession>
    <name>A0A654E447_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019903">
        <property type="entry name" value="RIC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36438">
        <property type="entry name" value="PTHR36438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="28477" checksum="9C34776095C18F70" modified="2020-04-22" version="1">MRVFDLTIRSLVDENYIYARALSYLGIDFYRHPDRTLREVCSQMGLQKGQVLKAFYLFDRSHRFSFQELGKYPLEIVIEYLKYAHHLFIKEKLPYIANLVHQYETLNDLKLIFPEFVEEFINHIYEEEDTLFSYINLLLKIQKGEVSNPQMALWRHRKLSLKQIHTDHCEEDELAGIRNLVEEADMSDLHWRVIAQEIKAFDREMWYHAEIENKILFPRAVALEAVVREKVNNLTPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E453</accession>
    <name>A0A654E453_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">panB</name>
        <name evidence="9" type="ORF">MARINOS108_50050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="52"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="29632" checksum="804290E2E15580CE" modified="2020-04-22" version="1">MSTAQGQFKKITTHRLQEMKATGEKIAMLTAYDYSMARILDASGIDVILVGDSASNVMAGNETTLPITLDHMIWHATSVVKAVHRALVVVDVPFGSYQGNSSEALRSSIRIMKESGAHAVKMEGGIEIKESISRVLSAGIPVMGHLGLTPQSIYKFGTYSVRAKEEVEAEKLKSDAQILQDIGCFGIVLEKIPASLAKEVSESLHIPIIGIGAGPDVDGQVLVVHDMLGITQDFKPRFLRQYADLNKIIGEATTNFIKDIRSKDFPNKEESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D1</accession>
    <name>A0A654E4D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025379">
        <property type="entry name" value="DUF4295"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14128">
        <property type="entry name" value="DUF4295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="5621" checksum="AA7C8DE0EB10FC10" modified="2020-04-22" version="1">MAKKVVATLKQPGGAKFAKVIRAIKTESGNYVYKEDMVPEAEVKNVLARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G2</accession>
    <name>A0A654E4G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="112" mass="12455" checksum="7A6836430C1A1377" modified="2020-04-22" version="1">MIGGLGVLPPPEIISMKRGIEVAKLDFGVEHFFQALANALGKIDSSRLHAQNHRIRKITMVLDEMLTQPADCDLKELTVEQESFLHDQASCKYKIISLNPNNPSDNKIEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q9</accession>
    <name>A0A654E4Q9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide mononucleotide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="23405" checksum="B60ACB2396749E25" modified="2020-04-22" version="1">MNEFFSQLLEQMYQTTWLEAVAVFFGLLSVWYSKQENILVYPTGIVSVLIYIYLTLEYKLYADMGINGYYFVMSVYGWYHWTDSENKPQIPITSNSKKQNVISILFFIVSFIVIRTVLVYFTDSDVPNWDSITSSFALVGMWLMAEKKIENWIAWIIADIISVPLYLYKGLPFTAFQFFVFTVLATWGYFSWRKTLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y5</accession>
    <name>A0A654E4Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="48010" checksum="A2893E34F1A330E2" modified="2020-04-22" version="1">MVHTAIGPLKAESIYLKRYAWPATGLAGKVSGNPQMIVVIPAFCEDHLPKALTSLHRCTPPTLEVAVLIIVNESENASLEIQQKNQACLLAIQQVIPTFQQHVLHVKLPPKKAGVGLARKIGMDEAVRIFEDRQVDGIIVCYDADCHCDDNYLQAIEHFYQDPQNNLGLVHYEHELHGTNHEAILNYELYLRYYTNALRVCGYPYALQTLGSCITVRSSAYQKQGGMNTRKAGEDFYFIHKTIPLKGIGEINQTTIYPSDRVSDRVPFGTGHVIGKYLEDEADDYSVYHPDIFEQLRPINKDLKDLYITRIFDISEVSPCLRAFYLENNFEEALYQILDQSGSYSNFLDRYYQWWDAFRVLKYVHFARDHFYASVPLHSAMQWLSLQLPELLLAEKDQLAQLLRMREYDRANTFYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E561</accession>
    <name>A0A654E561_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.75</ecNumber>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="10"/>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024901585" evidence="6">
        <location>
            <begin position="26"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="471"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="9">
        <location>
            <begin position="568"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="701"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="7">
        <location>
            <begin position="798"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1032" mass="108966" checksum="90FD3E76E05DB2B3" modified="2020-04-22" version="1">MNYSKFFKIASLVWGLMLMPLLMNAQSVDVWLTKGDQSVKLQQQSSLTFGSNGNVPNTITVNDANTYQSITGFGFALTQGSAEALSQLNTSTRTALLNELFNPASGNAISIVRISIGASDLSNSVYSYNETSGDVNMNNFSLAGPDQTYLIPILQDILTINPNIKVLATPWTAPTWMKTNNTWIGGSLNASYYAAYATYFVKYLDAMSALGIDIWAITPQNEPENPFNEPSMLMNSTEQKNFINNNLGPAIASSGHATKIIAFDHNCDNTAYPIDVLNNSSYVDGAAFHLYGGNISAMSTVKNQTGKNVYFTEQFTSTNGNFSGDLGWHMQNVVIGSMRNWSKSVIEWNLATNSSYGPKTPGGCSECLGAVTVNSSSSITRNVSYYIISQVSKFVQPGAVRIESNTTASISNVAFSNPDGSKVVLAYNSSGGAQNVKVVFGGQSFVYSLPGSSAATFVWSGETNPPTIPSAPSGLNAGAQSSSSIALSWSDNSNNEVNFEVQRSPTGSGSWVQVATPGANTTGYTNTGLSASTTYYYRVRASNSAGNSAWSNTSSATTHNQPTINPFNTVEAESYTSQSGTQLETTSDTGGGQNVGYADANDYLQYSNVDFGSGASSLEARIASNASFTGTIEFRLGSTGGALIATVSVGNTGGWQSWVTRTVSVSGASGVQNLYLVFKGGNGIGNLNWFKFGAGPTIPQAPSGLSASAQSSSSIALSWTDNSGNEVNFEVQRSPSGSGSWVQIATPGADATTYTSSGLSASTTYYYRVRASNSAGSSAWSNTANATTQGTSGGGIVSGGTYKITNKASGKVVDVSGVSTSNGARIHQWDWANGNNQKWVVESVGSGLYKLTAVHSGKVLDVVDASNANGKEIQQWDYFGSANQQWQIQDAGSGYFKIIASHSNKVLEVPGSSTSNGTKLVQSNSGSGDHQLWSFENLSGARLGEVSDEQQLTPSFSIYPNPVQNGMFTVSLPQVEGAVSLKLTDLSGRAIGIWSAQSPEIKITLPAGVKRGLYLLEIEGPSIRTVKKVHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E562</accession>
    <name>A0A654E562_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032187">
        <property type="entry name" value="SusF/SusE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16411">
        <property type="entry name" value="SusF_SusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="527" mass="56856" checksum="3D45F42B2A0DB00F" modified="2020-04-22" version="1">MKKVLSNLIAPVVIMAALFSCEDEISNSFDVLDIAPVIDEVTPNGSVKIGSEFDIVIKAHDGESSPLASVSAKLKDADGNELATKSGTMSGTSGTFTWAAADFGSTALDTGDYTISVTVTDVANLSVSGDYSFIVFDLPFDATYPEMYIAGNFNSWGADALELVAANTWQITSTLDGGGWKFKNTPDWSDIDWGDSDCDGVMEVATGGGPDTNCGHTGESIITFNDKTLAYTVELVEPIAQNITGLYLVGSFNNFEGSDEYKFKLDSDNTWILAEVILKEGDVLKFAEAADLSKKNWGDNEPDGEADLFGSSIVLDNSYSQAYYKVTFNDATLAYQFDFVKFPSISIIGSATTGDDSGWGIDVKLRDFGNNSFRHAMGIYEGAFKFRQNESWDNQWGGFTFPSGTATKGGGDVSVSLAQEDTYIIMFNPSSGEVSFTATEIALIGSATGDDTWSTDINMTRDLLDPAVWTLNVDLVVGEAKIRTDETWDYNWGPDGYDTPANFNITEAGNYDVTININTGVASFEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E585</accession>
    <name>A0A654E585_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="584" mass="61405" checksum="CBE31352E346D3D2" modified="2020-04-22" version="1">MDIERGIVVDSGFIVGLLLGLLVIFVSCKENEEPLQILVSHISIKGDFIEDGETSQLTAVILPVNASNQMVEWKVSNESVATISENGLLTAVSNGVVTVTASAKDGSGVTTQKSFNVSGIMAPVVLVEHISITGNNITDGRSQAFSAEVLPINANNQTVVWSVSDETLANISASGDLTPLKNGSVTVRASATDASGIVGEKNVSISGVLEGTDGTIVGTAEDILNAIVNANPGDKIYIRGGTYTFSTKINLSRDGAEGNLISLIAHPQDTERPKFDFSSMAENSGNRGLQLSGDYWYVKGIDVFGAGDNGMFISGNYNLVEFCTFSENADTGLQIGNGASHNTVLNCDSFYNADSSIENADGFACKLDAGDGNKFIGCRAWQNLDDGWDGYLRGADNITTTYVNCWAFKNGMLKDGTIGGGDGNGFKTGGSDDKLLKHNALYTNCIAAGNIVDGFDHNSNRGTVIMYNCSAHSNGRNINFGSSNIASSLTIKNSLSFAGGSGDSYQATATDITNNSWQDGLEASAIDFVSIDLDALSAPRKADGSLPDVQYLYLQSDSDLIDKGVDVGLDYSGSAPDLGAFEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5S1</accession>
    <name>A0A654E5S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">queE</name>
        <name evidence="7" type="ORF">MARINOS108_20984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="23620" checksum="72183AF7728FFF21" modified="2020-04-22" version="1">MKINTEDKVLTDLPLMEYFLTIQGEGYHTGSAAYFIRLGGCDVGCVWCDVKESWDADAHPKVPLSQMVADAKASGSEIVVITGGEPLMYDLGDFTNQLHDAGLKTHIETSGAHPLSGDWDWICFSPKKFMAPLPEFYEESDELKVIVYNKSDFAWAESHAEKCHSKTRLFLQPEWSKKDDMMPLIVDYVKKNPKWRISLQTHKYLDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E666</accession>
    <name>A0A654E666_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tpx</name>
        <name evidence="4" type="ORF">MARINOS108_11417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="165" mass="17603" checksum="70716FB43F28D64F" modified="2020-04-22" version="1">MSQVTLKGNPVNTVGTLPAQGVEAPNFTLVKSDLSEVSLSDYKGTRVILNIFPSIDTGTCATSVRQFNQKASDLDNTVVLCISKDLPFAHNRFCGAEGIKNVVSLSAFRDSSFEKAYGVGMVDGPLKGLVARSVVVVDEEGKVAYTQLVGEIVDEPDYESALKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E673</accession>
    <name>A0A654E673_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024838626" evidence="1">
        <location>
            <begin position="23"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="597" mass="61799" checksum="F0BCFAC76D1DF297" modified="2020-04-22" version="1">MTLNVRALCALFFITLCLTSYAQCPTGNVTGDVTINSNCNIAAGANYTITGNLTLNANLTLGAGAKLTVTGTLNNSYVGSATTRTISGGTVEVGTATIGDNYTLNLSGTTLNVTNGYTGGYHGGLTMTNAVLDIGTSFSEGFQQGTITLNNSDISTGTTFATSGGGTQLSLTNGSSIDAGTSFSFTGGSGRTLTVNNSSINSGTNFTIGEQSGSNITNGSSLVVGGNFLNDNGADMILDNSTITLTSGNFMNDFQATILAQNGSDITLSNGNMNTEDQSSLIIDASDVYINGDMNNDFHAQLTVRNNGTLTVTGDFNNGLQPNGDPADQGYVDVDGGSVSIGGNLNNSAGSSIDIDGGGSFAVAGNVTNGNESTPASITVPDGTFSYGGTMSDPHSGVSASSGDSECADGCCGSGCAALPVSLITFDALQEDDQVLLSWSTATEKDNDYFTLERSTDGRTFQPIAQVSGNGTSKVIQHYSFIDYLGFVSSSTSVYYRLSQTDYDGTFEWLRVIDLGQSAQVNRIQAFPNPAWQGDELQIEGVTADMSWEIYALSGGLMARGSFISGNRIDTQHYKPGTYLLKSFSGSASTTAKIIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E685</accession>
    <name>A0A654E685_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024911218" evidence="1">
        <location>
            <begin position="20"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="621" mass="67213" checksum="0EE4E9577F700326" modified="2020-04-22" version="1">MYRLLTFIALLLFSLSGHSQIDPLKDTLTISFDGSTTMEALEMLSRHSQYHVSYNPDRLPKKEIYSTYQRESIETILKGILGAGFNFKVHGSYIIIQVDVSESTSTPIHINGEVLDAVTGERLANTRIYEVSRLSATLSNEDGSYHLASRPDGDKITLAISKENYKDTVITVDKTYSDFLSLLLEPIHKTEITINSIKQAAGLFIDKREKKHTEDIPSGEDRWAQLSLVPGASTNGQVSSQVTNHISLNILAGYAGGVDGVELGMFNANRGQVRGLQIAGLANTAGGDIEGLQIGGAFNLSKSEMKGFQAALGANAVSGSAMGVQMALAANYSADLSGLQASMGANVAEDVRGMQASWGYNLARDTLMGIQMALGANMASNTSGAQLALGYNHAHGKLTGAQLGSVMNYTHHSLRGMQATLLYNHVGDTLKGLQLGTVNSASTLKGVQVGLVNMAEKVESGTMFGLVNLAKGEVIALDIDYNDVTEFNMSFKSGVKHFYTIITSGISYEKNFWTSGFGFGSQQNIAKFLYMGVELTGHTLLPSNQQITSVPINGRFNISLGGQITERMSIHAGPVLHYLYFYGINDRFNPMDLVGINPLLERSSSRNSQKLWLGYRIGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6E7</accession>
    <name>A0A654E6E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hpd</name>
        <name evidence="7" type="ORF">MARINOS108_11507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="367" mass="41717" checksum="5218CEC4D4214F21" modified="2020-04-22" version="1">MTPNETDFLPINGTDYLEIYVGNCKQASHYYKTAFGFQDLAYAGLQTGLKDRESYVLVQDKIRLVLTSPLKSGTDIGRHIDQHGDGVKIVALWVDDARKSYEETTARGAKSYMEPVVEKDEHGEVVKAGIYTYGETVHMFVERKNYHGVFLPGYVEWKTDYQPAPIGLKYVDHMVGNVGWGEMNTWVKFYAEVMGFSQLVSFDDKDISTEYTALMSKVMSNGNGRIKFPINEPAEGKKKSQIEEYLDFYEGSGIQHIAVATDNIIETVTALRDRGVEFLRVPAVYYEDLLDRVGEIDEELSPLRDLGILVDRDDEGYLLQIFTKPIEPRPTMFFEIIQRKGAKSFGKGNFKALFEAIEREQEIRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6W0</accession>
    <name>A0A654E6W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_90038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024994796" evidence="5">
        <location>
            <begin position="21"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="33"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="411"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="7">
        <location>
            <begin position="491"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="8">
        <location>
            <begin position="675"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="746" mass="83846" checksum="5F14E61B92C4AD94" modified="2020-04-22" version="1">MTRIFIRLLMLMSVVGKLCAQDMYTEMYRPQYHASPRNGFMGDPNGPMKFGGKYHLFWWGHLRSEDMVHWEEINSNALHGTPSGFGNWSGSVVMDIENTAGFNSAEDTAMIAVYTLHEDATGYQHQAISTSLNHGSFEYYDGNPVIESNEPDFRDPQVFWHEQTNKWIMVITKPVDRGIRIYTSDDLKSWDYESTFEGYGARKEIWEVPDLFELPLNGDPQNIKWVMTCGMGPNRMQFWVGDFDGTTFSIDPEENFFTGSHVGGEVFEDFEAGYGDWTVEGESFGGNPATGTFTDQQEVMGYTGSSLVNSFLNGDGSTGKLISPEFEISRPFINFQIGGGASANELGFRLVVDGEVVQSIASSSNTEIMQWRGVSVSEFIGKTGHIEIVDEATGGWGHVLIDHIVFSDELYDTRTENANWADWGYDFYAGKTFRNYDFDDDRKVWLAWMGNWTYARDVPTRPWKGNQSIPRALSLVKNEFGFQLIQQPIEELKGLRSNEYSITNQQVDGVVPVTVFQPEWNVYELKLSFKVSYRDQVFGVTLAQSDDNKGVKITYDAAASTLELDRSGTPFSFAYKRKSVAPIHFPKDSVLDLHIFIDQASVEVFANDYQTSISSLAFTNVLSTGLSLFSETGPTELLSLEAWDIASIWGVTPDQVQRPEVQEDPLKVDSGHSMVYPNPVSAGQYITFGKNNIQNASICDLGGRVVFTQSTGTNQVLIPDTLSPGLYLVKYISDGRHYSDRIIIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7B6</accession>
    <name>A0A654E7B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="370"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="432" mass="48540" checksum="A4BA6C822AF34571" modified="2020-04-22" version="1">MMNNYLRLGKQYLLILAGVFLYYPSIAQDTTVTTISADGPGDTYSLLESALGGSPLEVPDCDHTEVFKHIEELYDDELERNVFKFYIHKDIDTDRCETNVDRQRNEIKAYDPSPDYLKAIQREVVTYEWFFKIDEFFQPSTNFTHLFQLKAVGGNDAANPLLTITPRKGDPEQLQLIHGRGSNSYTTVTYTDLSLIKGQWVQAYCKVEYADNTGTLDVSLKLLDGTEVLSYTSNEIDMWRTGSSFVRPKWGIYRSLNDINSLRDEEVLFADFKVSEMGACPAWYEDADGDGMGDPNSFVYACERPDGYVQNNVDTCVDWFEDADGDGLGNPEVSQYGCAQPAGYVDNADDPDDTKNALVLNATIAPKPEVYPNPATNTIKLLHMEGAENYRVLDMGGRVVRTGSGSEISIESLMPGVYFLHTEGHVFRFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8V5</accession>
    <name>A0A654E8V5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ORF">MARINOS108_110107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="431" mass="47126" checksum="8F616F7454A23179" modified="2020-04-22" version="1">MEDKIIVGLDIGTTKICVIVGRKNEFGKLEVLGMGKAVSDGVIRGIVTNIDKTVNAIEKAVAEASEQSGIDIRVVNVGIAGQHIKSAVHHGSITRDSDDEITVEDVNRLTNDMYRIVIPPGSEIIHVMPQDYIIDYEDGIKDPVGMSGVKMEADFHIITAQTNAINNINKCVRRAGLDIENLILEPLASSLAVLSDEEKEAGVCLVDIGGGTTDIAVFYDNIIRHTAVIPFGGNIITSDIKQGCMVMEHQAEQLKTKFGRAISEEANPNEIVSIPGLRNRAPKEISLKNLAHVIEARMEEIIEMVHTEIITSGFHKKLAAGIVVTGGGSQLTNLQQLFEYMTGLDTRIGYPNEHLGKSKVDAVKSPMYATSVGLVLSGFRAIDIREDRYNEKIAKGKALKPRNKQGAKFFQNILEKTKGLLIDDIDDERDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9Z1</accession>
    <name>A0A654E9Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN repeat variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025050787" evidence="1">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="22334" checksum="0EF0CBC83EFA90D0" modified="2020-04-22" version="1">MNRIGSIWLMLVLGVMMACQNETPVILETSLIPSTAEVSAYGDVEGLSKATQRSDQRIVTEGDVLNGLKHGSWITYDKEGAITLLETFNEGKKQGVTLKFDKQGYVETKSYYHSDQLDGEYVVYKRKKVIETRNYNNGVLNGPLTKYYDNGTLMQEAPYVDGKLHGLAKWYDQEGNLSIAYRYEDGELVDKNPELEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA93</accession>
    <name>A0A654EA93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="21140" checksum="3DA7F5FF3F618C93" modified="2020-04-22" version="1">MQKRLLFNSKLLQITISRLCQHLIENHGDFSDSVILGMQPRGIYLAERIRKRLEEMLNTKIQLGYLDTTFHRDDFRRRENPKTPNQTKVPFIIEDKKVILIDDVLFTGRSVRAALDAMTMFGRPAKVELLVLIDRMYTRHIPVEANYVGRRVNTMTSQRVLVELEEQGKKDNIWLINETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB94</accession>
    <name>A0A654EB94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="804"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="285"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="743"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="840" mass="93827" checksum="41319193086444FE" modified="2020-04-22" version="1">MIWPLKMAWRDSRKSKGKLLLFVLAISLGIAALVGITSFRENLLQEINNQAKTLIGADIEIKGSEPLPDSLMLALYELAPEMSREVYFASMVYFPSTDGTRLAQVRALAGKYPYYGEIETIPAAASRKFQQGEYALVDEKLMIQYNVEIGDFVKVGQQQFEIIGRLQKIPGQTEIGATAAPVVYVPYNHLDQTDLLQKGSRVNYLQYFQFHPQVDTTGKWSQLVTLVDKKGFRVDDIEERKEETGRAFKDLSNFLELVAFTALLLGCIGVASSIYVYTKEKTGIVATLRCLGMKSSQAISIFLIQVGFFGLIGSIIGALLGVGMHLYLPVLVKDFIPVELTPQLSWLSVLSGVGIGVVVSILFALISLVSLRKVSPLQAIRSDSEPTKFQLDWLQITVGFSILVFLMALIYLQIGSLQDAAIFTFGLLLTIIILGLIGKGLAFGIKKLLPNSIPYVWRQGLSNLYRPHNQTSLLITTLGLGTAFIATLLFMQSLLVDRVSIAGAEDRPNTILFDIQTPQKEEVRQLTLDYDLPVMQEVPIVTMRLVELNGISKNEAERDTTITTPDWAYNREYRVTYRDSLIESETLKEGKWIGKVTNPSDSIFVSVSSGYAENLELKIGDEMIFNVQGALLKTYVGSFREVDWRRVQTNFLVLFPAGVLEKAPQFHVLITRIDNNQLSARYQQAVVRSYPNISIIDLELILKTLEEILGKIAFVIRFMAFFSIGTGIIMLISSIVLSRFQRMRENVLLRTIGASSRKLWKIIFAEYFFLGGLGALSGILIAILTTTLLGKFVFEFTFIPDFSQMIYVGLTITFLTVIIGLLNSRDVISQSPLEVLRNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECH8</accession>
    <name>A0A654ECH8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">MARINOS108_20387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="371" mass="43383" checksum="D871A247BA0A3109" modified="2020-04-22" version="1">MNNPFNDLKKLNPIKYSPISFSRKRPKTGLAPGSLIYTGKVHTDHVNIHVIDYTDERIDEVDIEDVNDLQQYNNPNSVTWINIQGLHDVDIISKIGEMMGLHPLTLEDILDTNQRPKVEEFDEHLYISLKMINHLDNLNKIDIEQVSLVIHENFVICFQEKPGDVFNDIRSRLKNGKGRARKRGADYLAYMLLDIIIDYYYETLDQVWARIEVLENFVVRRPQRIQLKDIQLLRKDLIQLRRFMYPVRDVVHALSSRSSSYFSDNTLMFIRDTYDHAVQVVENLDTYREILTSVMDLYLSQLSIKMNEVMKVLTIIATIFIPLTFIAGIYGMNFEHMPELGWAISYPVGFYSLIGVVTLVMIVYMKSRRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSN8</accession>
    <name>A0A654DSN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="369" mass="42501" checksum="E4AE55619F1ECEE8" modified="2020-04-22" version="1">MMEVREYSAEEYIQMITSYPNFLSSLRQNTLKSNELANELSTGIEKLKAVYPNLKPAKIYFTIGCMRSNGTTIDSLVLIGSELAMADQQTDISEFDGATKEWLETFFNSNPIDNLVLLNVHEYVHTQQKTQVNNLLSIAIREGVAEFVSTLAMEMPSATPAIAYGKKNAQTVLEKFELEMFYPNNQSKWFWSNYPNEFGVRDLGYYVGYQLCEHYYAQAGDKEKAIKRMIELDYTNEVEVEDFVEQTRYFSTSLDSLYQRFENKRPYVTGIRQFENNSTNVDAGIRQITIDFSEPLNGHNTGVDFGELGQDYFPKNDVTKRFWSEDKASWTISVELDPGKHYQLLISNNFRTSEDIPLKPYLIDFNTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSQ9</accession>
    <name>A0A654DSQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsule biosynthesis protein CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="81"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="402" mass="44531" checksum="A41056A7813C0535" modified="2020-04-22" version="1">MRQLSGSLLTFSILLFLLTNCKVSQQTTAPPPPDQHTVRLALDSIPLEKETFLITQAGDTLDTLFQEVDISIERLLPDTVTIMAVGDIMMGTQFPNKSYLPLNNGEYLWDDTRDLLASADITFGNLEGTLLDGEGDPKECNNPDACYLFKMPTRLATNLVDCGFDLLSVANNHANDFGPVGRKATRKTLDSLGLTSAGSTEYPYTVAKIGDLKVGFVAFAPNKGTLTFYNVEYARSIVTMLDSLSDLVIISIHGGAEGAKNMHVTRAREFYFGEDRGNIYEFSHAMIDAGADLVLGHGPHVVRAIEVYKDRLIAYSLGNFLTYGRFNLKGANGESPLLEVQTKSNGEFIGGRIHSFYQSYSRGPLKDERKQVMKNIQKLSREDFPENEILIDDEGRIIYIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT00</accession>
    <name>A0A654DT00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase RhlE</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE</name>
        <name evidence="11" type="ORF">MARINOS108_10206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="233"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="44670" checksum="CB05D0567DA3D457" modified="2020-04-22" version="1">MKFSELNLDPKLLEGIEAIGFENTTPVQEATIPKILEGKDLIAAAQTGTGKTAAFLLPIIHKILTEAKDDGHIKALVIVPTRELAVQIDQQLEGLSYYTSVSSLAVYGGGDGQSFDREKKALSEGADIIIGTPGRLIAHLNMNYVKVSQLDYLILDEADRMLDMGFNEDITKIIGYLPKERQTLLFSATMPTKIRQLAKNILKDPEEISIAISKPNEKIVQAAFIVYDGQKIELVKHILKPDWLRSVIVFCSTKDNTKRLTKELKKANLSVEEIHSDLEQKSREQVLNQFKSRKLKILVATDILSRGIDVEDIDIVINYDVPNDGEDYIHRIGRTARAASTGAAFTFVNEKEQSKFQSIEQLLGKPVPKAKIPPHIGEGPSYSPKPYRGGGGRGGGGRKGGGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTY2</accession>
    <name>A0A654DTY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16668" checksum="395DAC67D6E8B45F" modified="2020-04-22" version="1">MKSFRLKTHRPESTYTKPHFFILNKGLNSGKPLIAPCPNCFVCLTENEGDREFMYWLCFGLWRSKSFQFFLRGSVIPFISIHELRKHLIESETKASTNAQAFEKAINALRLLEIHEEKIKVSLKMVDTARRSIFCQLLRDTGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUE6</accession>
    <name>A0A654DUE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lamin tail-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024804664" evidence="2">
        <location>
            <begin position="24"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="247"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="626" mass="67881" checksum="ACB1E8B474BD9DF8" modified="2020-04-22" version="1">MTLLKTKTILLMLLAFYSSSAQLSINSLDTDHTIDFDNTLLGVNLGPLQGLGLVNLPVTLGQLDSRAWAIYGMSDGDVPFDGTGLLGDFTGGISQGGVALSALYAFNTATILSPDYALGFQANDTDMTPGSLRLKLQNDIVATTIRTVTVSYDVYVYNDQNASSAIDLAFSSDNTIYETVDSKEVTTPTTADGSPEWVKYSVSKTIYGLSWDSGTNFYLSWQFDDASGSGARDEFSIDNIVVNVGNSHPDILITEIMYDPNSAEPDYEWVEVYNNSIVPIDLEGFILYDNSGSAGETPITESYTLAPNEGVILIDQNITDADFQAAWATGNTIPTLTVNLPDLSNIGMSLGLWGNSAYYDNGNLTNALDEVTYQNGSGSWPAVGSSDGKSIYLQSLASDNNTGSSWAQSNDATSTPTGYAHTIPAQGGGSGSDVGSPYAGEGALPVTWLSVDVSLVNNQRPKITWSTAQEINNEWFHVEKSYNGENWSVIGQLKGKGNYKGVSVYTYEDLPLIRSCYYRIRQIDYDGKWEHSEVRYIVPSHTGETEIYPTLLENGNRTLNIKNLLPGVSVDIIMYTPEGKLAFQTHLIPESTGADLMIPEYIINGTHIISISSPTGILHKSRIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUF6</accession>
    <name>A0A654DUF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylalanine 4-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005960">
        <property type="entry name" value="Phe-4-hydroxylase_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01267">
        <property type="entry name" value="Phe4hydrox_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="28885" checksum="1FC8D808B2375E44" modified="2020-04-22" version="1">MKQIYGHYTDEDFQVWKILYERQIKNLPEAACDAHMEGLEKVIFVPSEIPHFDGTNEILEKLTGWRLAVVPGIVPDYTFFELMSNRRFPATTWLRKMEELDYLEEPDMFHDVFAHVPLLTNQAFVDFLQELSKIGLGYVGNDYAIEILSRIYWFTVEFGLIQEQQGLRIYGAGILSSAGETKFCLSDKPPKHDFDVRTIAQTDYRKDVFQEQYFVIKSFEQLYQSLPEIKEVLAEMVEKRKEESVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUG6</accession>
    <name>A0A654DUG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="268"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="38817" checksum="ADECB1EBEDFB053C" modified="2020-04-22" version="1">MADDKNKNEDPEEERDDQFDDDEDFGLPDLEYDELDDDDDDEDLSDEEQEDALEEEEIVPKDDEIDLSGDNLDDVELTDADLEDSDEPEDWEKELEKELEDELKSDDETGGFYEEESYEEFESQGESQVASSVFDDDSNDTGFGATSEYTEETYDTPTYTTSSGVSDEDQAESRGKFVRTVVIGTLLFAVVAVVLYLYSGSDDAPEEKKVAKVEQKAPAKKPEPEVKEVPKEETPAKVEEKKPVAKPKAQKPKPTPNTTPAGEITKFDQPTGKTYVIVGSFFDDDLATDYASKLASEGKSPMVIPPFNDSRFYRVAIAGFDTFKDAQQSLDGYKSEYGSDVWTLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUH4</accession>
    <name>A0A654DUH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="120" mass="13885" checksum="4BDACF3DCE116806" modified="2020-04-22" version="1">MYISSMYSKELLKGTIGVMVLKLLEENDRMYGYEISQRVKALTDGKILLKDGSLYPALHKLLKDGILGYEEQRIGKRVRKYYFLTSKGKKEKDVLMAEMKDFILTIQKVIFNEFNPGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUI3</accession>
    <name>A0A654DUI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="148" mass="15570" checksum="41FDC66AB29F6B63" modified="2020-04-22" version="1">MPQDKKYNIGLVLSGGGARGFAHLGALQALHEAKIYPDVISGVSAGAIAGAFYAHGMAPEDIFELLKEKGVLEYSKFGFPINGLLSLDGLVSEIKENIPCEDVSELSKPAFFAATNLNTGKVEYFSKGNLCKVVAASACIRSSSALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ4</accession>
    <name>A0A654DUQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="25254" checksum="BEFD9E0278EC5E30" modified="2020-04-22" version="1">MQPSFQTPDLRPELNMIKSVKDDNSERELWKAFQSGDRLAFETIYNNSIKYLTNYAMRIASDKDLVQDSIQDIFVHLWNKRGELASVNSIRFYLLKSVRRDVIRKMARGNKKSSLSSLTGNSKVDFQPSYEMIKILGEESSERILKMRRELDALTPRQKEVLYLKYYSNMTNQEIADILGINMQSVYNNIYRALEVLRDRLHVVLPWLISGTGSFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV92</accession>
    <name>A0A654DV92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="302" mass="32917" checksum="3E8DB0B4826ACD43" modified="2020-04-22" version="1">MNKHETSDVIIIGGSYAGLSAAMALGRSLRNVLIIDSGFACNRQTPYSHNFITQDGVTPGELSSRAKSQVLKYPTVKFLNGLAVSGMKTKSGFTITTQTAEVFHARKLVFATGIKDIMPDIKGFAECWGISVVHCPYCHGYEFRNQKTGIMANGERAFHLAGLVNNLTDNLTILTSGKADFEATQMATLDRNKIEIVETEIDEIAHQNGQIQNVLFKDGRQSDFRALYAALPFKQHSDIPLSMGCELTEPGYIKVNDLQETTIGGVYACGDNSAMMRSVATAVYTGNLTGAVINRELTAEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF0</accession>
    <name>A0A654DVF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025003052" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="417"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110321" checksum="C1D175252C2BDC9B" modified="2020-04-22" version="1">MRQFTKLFIIIIAMVSASSYTDAQDFKISGTLLDSETKEALIGATIIEKGTTNGTVTDLEGNYQLMVSGSEAVLVFTYLGYSSKEVRVNNQSVINATLDIDFSELEEVVVMGYGSVRKSDLTGAVASVKGEDLLKVPNASPVQALQGKVSGLQVLSPSGDPGATPVVRLRGVTTLNNNNPLFVVDGVIIEKGVSDNSGSGTPLDFLNANDIESVEVLKDASATAIFGSRGSNGVIIITTKRGAQGAPRINFNAELGWQVVANKIDLMNGKEFGQYVNDIDLTEPGPYNVDQLSSTDWQDEIYNDYAPIQSYSFSFGGASEKVDYYFGLGYFGQEGILPKSGLERITTKINTNYEIAKNLDIGLSLSVALKEKQNSPGVVNTALRAWPIDAPYTTDPATGEKIFAEVQGGGNALAAIEYTNNVNKSIESVGNVFAQYAFLDGFSVKSSLQFSLGMSKNKSFTPEYFVAPLQQNETSDISQSYNDNSFVLWENTISYVKEIGVHRFNTVAGYTTQRVKSEFLSGSAQNLLRDGESFWYIDASDGDPLLQDVSNNASHSAIQSYLFRFNYSLMNKYLFTATYRRDGSSKFGPNNRYGVFPSLALGWNLSEEAFFPDVSFLGNVKLRASWGIVGNDKISYDAQFPQIDQSFGAVFGQNEQYVAGAAYATGGNPNLKWEETEQFDIGLNFDMFNGRLVSEMDYYVKTTNDILVNLEPIGYTGLGAFQQIVYNVASVENKGFEFSLNWQDDIGNFNYKLGFLGSTVKNTVLELGQDIGVDSLIVAGDLGNGQQVSRTAVGQPIGFFYGYDAIGVFQTQQQVDATPHLFGQTVGDLIYRDANEDGILDGDDRIMLGNSIPGLVYGFNTEVGYKGFRVGLDFQGQTGVDIYNGKQAVRFSLLNYEARFLDHWTPSNPSNENFRAVSGGTNYTPSNYFIEDGSYLRLRTVTLSYSFQQAVLNSVGAQSLKVYVRGTNLFTKTQFSGYSPDLGASSALDGVIDKGVYPITKVYSVGLNLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW13</accession>
    <name>A0A654DW13_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="29889" checksum="C6D9768A837ED8C8" modified="2020-04-22" version="1">MENTVAKKLESLVKLQSIDSERDELLKIRGALPDEVMDLEDEIAGYQTRVEKQNSELAELEENIASNKTAIKDAEKLIKKYEEQQMNVRNNREYDAITKEVELQQLEIQILEKRIKEAYVKIDSKKEEIAQTEGILSERTKDLDSKKNELDTIASESEADEQKLMKDRDKAAKQVEDRLLKSYEKVRENMRNGLAVVPVKRGACGGCFNVVPPQKQAEIREKKKIIVCEHCGRILSDVEDEVIEEEKPKRRTKRTTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD8</accession>
    <name>A0A654DWD8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1625" mass="181891" checksum="4237783E6DD5BB48" modified="2020-04-22" version="1">MSIKATVSILFFFIGLHFLVAQEWIETDIVAPDLHPDLVADFANNMIVYKDFLLVSAPRALNGKYSSGSAALYEYQSGRWIQKTRLYSEELYSEDSYIRGFSLGMAMNDSIIVIGAPESNLNDLHMVGTVHVFTRSSNDWSAFKQYTIYPSDTISSRRFGASLHLEGMKLFVSSGAHGNVFVYELGASEAILKASLRSSLSLNIVWGNSRQFGQSIKANKNYLFVSAPGDEMGECPDGGGIYVYDKNNDWEGKIEQDYALFHDCEEIRFALGTHFDVNEKYLISYVRDLYNGEKLDVLVYDLSELTTGDPNQPSNIYSIPLEKPFSVVEIKFLSTNQFLMTYDNDDRYKTLNFFINDEGRIELIGEVTTQITNPLFGQKIEVHNQQILNGSQNKILVYEKPEINQNPPLAIVDTITTPYYTTVNTNFGRVIAQSDSYVFAGSPYEGDVFSNQGMVYIYKILGDSLSLIRKLHPPNPVSNGIFGYSIDVHENHLSVGAPGSGGNDGVYMYTYEDTELKWEGSLRTELIKPETSTEGEVFGNSVDLHHNEMIMVGFLGHNSPSYERTTVIYHLENGRWVEKYKTQIASRGGGEVGADIYGNYAVSSGSSGADLHVFKRNGDNWKIVKELSNSTDFYCAPSLLQINERFLYAPATYSKDLRIYNLLNIHDGVPEIMVNTPFQIEPWDNSFDINSDVLAIGNHNRDIIYLYSYDGLGYTLADSIVKNEMMDFGYGVSLRENTLIAGAPNKNLPTGNWSGQLSLYKRSNSIPDTPITVDSIHGVSDYYGIGDTLLIYVAFTDTVFAENDPFLILGDNNEMKASYKSGSGSSILTFELVVEEGIKMDPLEINNSFAMLHHGKIYNLNNPVNRILPDPYSQNSLSISKIIVDGVSPVPELISVGTAVNGIFEIVISFHEPIEGFDESDLVVENAEIQEIEMIGDSAKLVVLPGAEGEMQFWIRPDSYFDLSGNSNLGSDTLKVIYDITPPELFFTAPQTIVTNFDVQYSFSEPIKEIKNSGFGLENGMFLEQSATPGRLTVDPLDSGWVKIWIEQNSFRDFAGNWNIKSDTVWVYNDTIPAQLFQYNWPTHKLEGQVNIPKLVDLDNDGDLDLFVLQNYPVIFENNGTNFIEKSRLVNETGFSPNISWVDLNHDGLLDAFVYSNSVPYDATVLINLGNFEFERISLWEISSPQVDPQYAWGDIDNDGDWDLIGNFKPPSSDEVAVRVIKNENGTLTSTRNHYQGRINSRQPFADFNNDGFLDIALVIGEECNAKLLLLLNDLGNHFKKYETVINVPDGDNAEIVWVNINGDHLMDIASIGNNPCGVGGNFKCYVNKGDNVLEYKSSLITKKFTSRPVFLSADLDNNGEVDQILYGIDESNTETRIFLQSQPDPSHRLSGGLANGSMDIGDIDNDNDLDIVVVSGRVNEQSNLIIYENRFNISHYNTPPTRPEQLTTSLSGNTAKISWKPSTDDHSNVLYNLQVLKDGIPLRASSLDSGIPKLVLFRDAFLKNEFHLTIEEGSYYQWSVQAIDESWNASEFAPFEEISSPLEANEIGEPRFYPNPVTKDLMIKSNSEILNVEIQSLTGEIIQIIRLLDNKASIDLSDLPNGMFILKLETRNGKKLTYKLIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX3</accession>
    <name>A0A654DWX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5302" checksum="5CB1FED3D702E0CC" modified="2020-04-22" version="1">MFLKANGVLSFGLFGMNRSMNWQYLGKKLPENYVIYKGSLLKMLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX44</accession>
    <name>A0A654DX44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusC/RagA family TonB-linked outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="140"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="404"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1046" mass="113667" checksum="EC6F98056E4B68DE" modified="2020-04-22" version="1">MKNNYMKREKWRDGLSVMIFQSLLCLSLVLFGSSAIAQDRTVSGVVRDTETGEALPGATVLEKGTSNGTVTDVEGRYNLNVGKDAVLVISFVGYQNLEFTVGAQAVIDANLTLDVSSLQEVVVVGYGTQKKALNTGANLRVDGENIQKLSTTNALQGLQGQAPGVQLSSSSGQPGSGMRVVIRGAGSLSGTGPLYVVDGVLTGDISYLNPADIASVDILKDAASAAIYGSQASNGVVLITTKKGKAGQSRVTFDSYYGVQNVARKADMLNAREYATIMNEAAINSGKLPYFNGGEIDSLAANANSDWMDEMFVNNALTQNYVLGFSGGTDVSNFSSSVSYTSQEGIVGGGEVSNYERYGFRINSERRLFDGILTIGENMSMAYTNTRGIGVGNQYNNTLRSAFNTSPFVPMYDSLGNYWDNSNATWYNGEANPYANMMINNQSEGNGQKLLGNIYAELKPIKGLSFKTRFSLDYYANEGHSYAPEYQLSIYAFRNYTEVGQSLSKGRSILWDNWASYDLNLADHGISFMVGSSVYQFQGSSMYTSNRDAVFVGLKNAYINNTTNTDGANININGGGNDPDHRLSYFGRLNYNFREKYLLNATFRADGSSRFADGNQWGYFPSVSAGWILSEEGFLSSSSLVRYLKLRGSWGQVGNQNAGAYQYLAPISTQNVNYIFGNTEGTLTSGAYPSRLANPALQWETAEQINIGFDSRLINGGLSLSVDWYKKTNKDWLIVAPVLATAGADAPYINGGDVINTGIEVALTYNSSFGDLNYTVGVNGSYNQNKVGEIPTSDGIVHGATNQLFANSLEFYRAQSGYPIGFFWGLETDGIFQNEAEVKAHKSQEGKLVQPAAKPGDVRYVDQNGDGVIDDGDRKEIGNPNPDFIFGLNVALEYHGFDLSVLGSGVAGSQIAQSYRDHSNPYANYTSDILNRWHGEGTSNSVPRVTENASNWVEFSDLYVKNGDYLRINNITIGYDFGKLIPSESFGKLRLYASVLNLYTFTSYNGMDPEVGFGLDNGSTDRFSSGVDLGYYPRPRTYMVGLNVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX59</accession>
    <name>A0A654DX59_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TPM_phosphatase" evidence="4">
        <location>
            <begin position="59"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22878" checksum="B0F0372E7AE685A7" modified="2020-04-22" version="1">MVVVGRMLLAIIATSQFMRNFQYFLLLTLLTTFGCNSQSQKSTPQRTTYSNVPELYARVNDYADILSDDEEANLNQLLKSLEDSIGSQLVILSIVSLDERTIEEYSIDVADNWRIGRANYNDGIIITLAMKDRMIRIEVGYGLELIIRDEIAKKIIDSTMIPEFRTGNFNAGLTKASEKIINLIYSNPELVGKKWEPNNNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX68</accession>
    <name>A0A654DX68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032595">
        <property type="entry name" value="DUF4905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16248">
        <property type="entry name" value="DUF4905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="256" mass="29322" checksum="05ABBDD3E8ED1FD5" modified="2020-04-22" version="1">MNKNTSINLVAVPSFAFSLSFTSKIWQVALDAGTGYMVLELRDEDTGEVKYQLLDLKSLKDKKSFEIPEADWWTTVLRFYHPFLLLERYNDPQNPLSKDLLVYDTLSLSLNHVLTDFQLIQMESGELMGHVPGDQSNEQRWSLGSRTEPLAGSNVRYPVYYAPGSEYYTLVKEFLGMEEAPVGFEYDEYGKNIIISYYERLGTKFDRKLLVMQGDVELYHEVVDKGLNGYASGSFFSFNNLLVFVQNGNQIHAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX71</accession>
    <name>A0A654DX71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024816729" evidence="1">
        <location>
            <begin position="35"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="393" mass="42451" checksum="5C98E580110B3B25" modified="2020-04-22" version="1">MSNTYVNNQNVRKMKKYTMIFSLLFYTLSGYSQSCTNPTGSVISGTNTNYNCHQYVKAALVKGWVNMSNGYPSNQSSIPNLSSATIETDNDFIRVCNNYEAKAISMNHAQNNADHSAVVLNGGMYSYDYGNLASTPGFGSQVYTHGHARSFTNACSHKFYSTTSDVSISGPSSVPTGATATYTLSAPSNISADHWGVNTTYFDILSSNSSSVTVKAKSSAGSGYVKVYLRTSCMSSGEFKPSKQKTVSVVADCTGTLNGGALYTFNNVSSGASNTVAMNLSSWTWVKTSGSPSYWYTGSGGKYMYFSLSSGCATFNAYNSSCNLTLTFCAYGGYTMQYDDNEPMEYQVHNLLTNKLERKGTAAPADEPEMLRDLPAGLYVLSIGNTKKKVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG1</accession>
    <name>A0A654DXG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="385" mass="43847" checksum="BFCE162922AA1B7A" modified="2020-04-22" version="1">MSKIRIAFFLDVMKEDFDGVSITMHQVINRIPKETFEPIFITPQPPERDFKYPVYQCPYLNIPFSNKDYRLALPGRMKELTDILDDFGPDILHFSSPSGLGGFAVKYARRKQIPVTTIYHTHFPSFANYYLRYIPFVEKITEPIVHRLFWLYRGSTRVFAPTKSMEEYLLGKGVKSDQLKIWGRGVNTERFSPEHRDDLLWPQLPEGCKKVLFVSRLVKEKEPKTLIRLYNLFQERRPEIKMVITGEGPTRAKLEKNMPEALFTGKLTGLDLSRAYASADIFVFPSTTETFGNVVLEALASGLPVVAAAEGGPKDIIQDGETGVLVEPQQEEAFFAEIVKLVDDAAYYEGVRNAALAYARSQNWESLCQELFSTYTALVQSAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK8</accession>
    <name>A0A654DXK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="10">6.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_11105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.3" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_N" evidence="9">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="382"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="776"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1226" mass="135149" checksum="A4245B4F0C2A788E" modified="2020-04-22" version="1">MIYIFQKSTELIYVVGSKVEITPDTEKKLEWLLSGAKLLPDQSIQGSFVGPRKEMITPWSTNAVEITQNAGIQGLERIEVFRADKGQLFDPMLQQKYKLIDQEIFTLKITPAPIQHIEDLEAYNKSEGLALSQEEIDFLKEVSEEIGRNLTDSEVFGFSQVNSEHCRHKIFNGTFIIDGDEQPMTLFQWIKKTSKDHPGQIVSAYKDNVAFVKGPVVEQFAPRTQDKPDFFEVKDFDSIISLKAETHNFPTTVEPFNGAATGSGGEIRDRMAGGIGSFPLAGSAVYMTSYSRLEEGRKWEEKVNPRKWLYQSPKDILIKASNGASDYGNKFGQPLICGSVLTFEHEENNETIAFDKVIMLAGGIGFAKLKDGIKKKVEKDQTVVILGGDNYRIGMGGSAVSSVDTGAFDTSLELNAVQRSNPEMQKRVANAVRAMAELDDNPIISIHDHGAGGHLNCLSELVEDTGGDFKLENFPMGDPTLSEKELIGNESQERMGLVIDPDKAEYLRNVSLRERVPYYEVGTTSDKMELKFSRTGATQAPFDLKMSHLFGASPKTILTDKTQAKSFPEKDYDASKIEDYIEKVLQLEAVACKDWLTNKVDRSVTGKVAVQQTVGAVQVPLNNVAVMALDYLSNKGIATSIGHAPVPALINAGSGSRLSITESLTNLVWAPLTLGLPGVSLSANWMWPAKNDGENARLYQAVKEMSEFATALGVNIPTGKDSLSMAQKYPDGKKVLAPGTVIVSSVAEVSNLRKVVTPNLKDVSDSSLIYVRFSNKPMAIGGSSFAQANAFIGNEAPDTDPDTVVKAFNGIQELIQQNLILAGHDVSAGGLITTLLEMNFPNTSGGMAINLDELTETDITKLLFSENPAVVIQTQRPDNVLNLLKLHGVEATVIGITTNKRTISLRKDDWNLDLSIDHLRDIWFKTSHLLDREQSEPGHADLRFNNFKEQPLAYEFPENYTGTFAKYGIDPKRRTSTGVKAAIIREKGVNGDREMAYALYLAGFDVKDVHMTDLISGREDLSEVNMIVFVGGFSNSDVLGSAKGWAGSFLFNEKAKAALDAFYAREDTLSLGVCNGCQLMMELGLIYPELGEQHPRMHHNSSGKFESAFINVDVLDNSTVMFGSLSNSKLGIWLAHGEGRFMLPGQPEDYNIPVKYSYESFPGNPNGSDFATAAVASNDGRHVAIMPHLERSIFPWNWAHNEEIKDNEVSIWIEPFVNARDWIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL3</accession>
    <name>A0A654DXL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-(Acyl-carrier-protein) synthase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="232"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="35583" checksum="E848672A103F8F5A" modified="2020-04-22" version="1">MKITGISTQIPRLVAYNHDIDWIPPSLRQRLIEVIGIDKRHIASAHHKLSDFAVMAAEDVLSGSGVNRQDVGIILLITQTGDQQVPNTVIDVQTKLGLTNDTLSLELNMGCSGFVHGLHIMERLLSRDSRNHGLLICGDLSSRLIHDKDSGTVPLFSDGVSATLVTKQHNVEWDFKIGNNGSNREAISMRPIDNSVRAFEGSGYLKLDGHQILNFGLKSVVPGIQLFQNEASTSIDYYFFHQASKIINDSIRNKLNIPSDKCPMTLDRFGNMSSATIPITMSTISCLQEKENRIMLCGFGTGLSWGTAVVNLPSIDYFSICEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM0</accession>
    <name>A0A654DXM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="307" mass="34261" checksum="CA0885899A3E5844" modified="2020-04-22" version="1">MSIIVENLTKKYGEQKAVNDISFEIKTGEVVGFLGPNGAGKSTTMKIITCFMAPSSGDVRLDDDSIHTNPETIKRKIGYLPENNPLYLDMPIIDYLRFTAEIQGVPKGAIAGRIGEMIERCGLDREKHKNINELSKGYRQRVGLAQAMIHDPEVLILDEPTTGLDPNQIVEIRKLIKDLGKEKTVILSSHILSEVEATCDRILIINRGRIVADGTSDTLRSQSQGQELLKIHVEADPAKVETAVRGLPSVEKVMPLDGKAGWFNVQSKPDLTSRKEIFDLCVQNKWYLMEMSGLETRLEDVFQKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM4</accession>
    <name>A0A654DXM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase PhyH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="33558" checksum="0877330B939695F5" modified="2020-04-22" version="1">MKSLFKDPQVTQKYQKDGYVILDLLSPMEIKAERDFFYQHVHTFDKEPLYESSRNNSNQTNDLINNHLQQVFLHKTLDHIRNATVYGGTYMVKPMGSEDYLPLHQDWSIVEEDQFETAFIWCPLQTTDQTNGGLFVVPGSHHFYQNRRSGSLPCPRIIPNRRIKPYVKHLKVSEGQVIIYSDKVFHGSHPNTRQTPRIVATARLVEQGARLTYYHRLSNEKVGVFYFSKDTYLNGITQLVQGKIPDGLQPEYLEDFRNEEINEANFIQNIKKHLPSPTVLNRLAAWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM6</accession>
    <name>A0A654DXM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="6681" checksum="523AFBD06D46A93E" modified="2020-04-22" version="1">MCPELIESRKVANLPNHHNGIHEEMRFASLRAERMKVGRPSFDELSESTPDSYREAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ8</accession>
    <name>A0A654DXQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="28222" checksum="7C71B905B8367956" modified="2020-04-22" version="1">MNRHFTDADWSQNHHSFLTSVTFSPTPINRKSQSNPLFCITLIYAMRTSACLKALPFLLFLGGCVMHNRMTSPVALPKEQQSWTYGLVVDPILASDDGEVFGFQPIISYRAGLDKGNELGVTLYGVYLPGAVIDLKHQFYQNGNFTFSGDAALYGGALRPFGLQYDLLFGSQKFYGLAGVNVDFTSFTNYPAAKVIGIGSEVPGKRGLGFQITYANRLVPDANDRYNWLMIGLKMDFRNSKKKFRDPAKQIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS0</accession>
    <name>A0A654DXS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-D-xyloside xylohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025069527" evidence="3">
        <location>
            <begin position="20"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="4">
        <location>
            <begin position="220"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="790" mass="89714" checksum="437644702B941822" modified="2020-04-22" version="1">MNTLKYLLLFLTFSGYAQLQNTGILNEPPDISKDFSDLRNTYFLAEDLTSFDPATGKGTVRYIRNNFATRQAFDNMLMRLVPVSANEFPTTEYAVAPEHPFSIEFTSARTVRIRMTSGPQYRKPEESLMLVEGVAPVDTKSWKYSKTTSGHEYKSEFGRILITEKPWHVYIYDEKGKLLTQTIHTDDLKNTYTPVTPFSYVRRASDYSRSMDAVFGLSPGEKIFGCGESFQEFNKRGQKVILWTDDANGVQNETMYKPVPFYMSSRGYGVFMHHSTPITCDFGKYFSSVNSMMIGDDELDLFVFIGEPKDILDEYTDLTGKAPMPPLWSFGFWMSRITYFSEADGKKVASSLRKNKIPADVIHFDTGWFGVDWRCDYQFPTDRFPDAPRMITDFKKQGFEICLWQLPYFTPQNTLFDELVSKGLAVKDGKGNIPYEDAVMDLSNPQTVSWYQDKIASLLREGVGAIKVDFGEAAPANGIYHSGRTGFYEHNLYPLRYNKAVADITKEVTGYPFIWARSAWAGSQRYPVHWGGDAATSNGAMAATLRGGLSFGLSGFSFWSHDIGGFVTTTPEDLYRRWTPFGMLTSHVRSHGEPPTEPWEYGEDFMNAFRLADNMRYELMPYIYTQAKYSSENGLPMVRALFVEYPDDPGSWLVDDQYLFGSDILVAPLLENGTSREVYLPPGLWIDYQTEKEYPGGWHTMEVGEIPIVMLVRDGTILPHAKLAQTTKEIDWKTLELRVFSTNGKAAGLLYTPEADAIGEIVLTKVGEDYKLTTDPFKDKIKYIIKKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT4</accession>
    <name>A0A654DXT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="213"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="470"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="617"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="720" mass="81256" checksum="D34D5F25351E4940" modified="2020-04-22" version="1">MVNQLLKYFLPDRLDTSDWVVSSKAKYLIYGHMVTVLTGVLGMIVNISPFDRQPFFIDLGLISLMIGNLFLLKWSFRLCRFNFHLITWSIIFVLATFINPLFSYEYYFLIWSVSAVMLFTSKLKIYFFFVAGLVSFHLPKLINQQVDAEFNYNPVFLFLMLLLIFQVFYATNQYYLSVINRKNQQLEHDKELITRQSEQIKEVNALQTRFFTNISHEIRTPLTLISGPVRQLIDFGNNLTDEQLKQLRLADQNGKRLMNLVEQILDISKLEAGVLPLHMAQADLSAFVRGIASSFEALSEVKKIDLIVETPEEPTQVWFDKDSIEKILINLIGNAFKFSSDGGRIIVRLETNSHEQAVLTVADTGRGISEDQLAHIFERFYHTESDLQGSSGIGLSIVKALVDRLNGSVEVKSTSGSGSTFKITLPAGKHDFPEASIQEQTEVNHQTSPVALGTDDASSPVLHQPAEADRLLIIDDNEEIRAYLTDLLKGTYHIFTAETGKQGIDVALQQLPDLILCDVMMPEKDGIEVTRILKTHELTSHIPIVLLTAKGDSSSKVKGLESTADDYVVKPFDRKELMARISTLLINRRKIRNKFSNTFITKADDLDVPSLDKQFLNKVLGLMEEHLADDTFTVEKLGELIGMSRSQLHRKLTAIIGQSPKKMIKTMRLQRALDLLKKQAGNVSEIAYMTGFSSPGYFASSFREEFGITPGEVGKKTINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB3</accession>
    <name>A0A654DYB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase PhyH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="280" mass="32013" checksum="5DB9C5B0D7840A87" modified="2020-04-22" version="1">MEAAIKPPVFLNADIQHSFEESGFVKLPLLEDQEVQHLVKFADEVLHQPRPVIGFAEKLSYYISIFDNNADHKLTVNNLIGQLVQSKLSNILVDYETFYSNFMIKYPNNGFLECHQDFNLVDESIYTAFNLWCPLIDTHEQNGGLSFIPGSHKITNLYRGPNMPFSFTTYNDQLIKKGIPLPVKAGECVIFDHKTIHFSTPNQSNQIRYAVQSVLKPMEAESLLYLYDSHREQAIAKKITTQFTIESGFWSEKTAELPTLHTRPYANPQLQDDVQALIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD8</accession>
    <name>A0A654DYD8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">pgk</name>
        <name evidence="12" type="ORF">MARINOS108_12059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="395" mass="42363" checksum="88F57AE8A22DD0AF" modified="2020-04-22" version="1">MRTIDDFNFRNRKALIRVDFNVPLDENSQITDDTRLRAAIPTIKKIIDEGGAVILMSHLGRPKTGPEEKYSLKHIVADLSEKLGVSVHFANDCIGDEAQEKAKALGNGEVLLLENVRFYPEETKGDEAFAEKLASLGDIYVNDAFGTAHRAHASTTIAAKFFADKCCGYVMQQELVNAEKVLGEPTRPFTAIMGGAKVSDKILIIDRLLDVADNLIIGGGMSYTFSKAKGGNIGKSLLEADKMDLTKELEAKAKAKGVNLILPVDTVIADDFDKDANKKTVPAGQIPDDWQGLDIGPETIKLFSETIKNSKTILWNGPMGVFEFPAFAVGTEAIAKSLVSATEKGAFSLIGGGDSASAINNLGYGDKVSYVSTGGGALLEYMEGKVLPGVAALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH9</accession>
    <name>A0A654DYH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ORF">MARINOS108_12005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD14525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="558" mass="59812" checksum="4268EB5BCB98D465" modified="2020-04-22" version="1">MAQELNTFSKVITQDPTQPASQAQLYATGLTEEDMDRAQVGIVSTGFEGNPCNMHLNILAHQVKKGVREADLVGLIFHTIGVSDGISNGTVGMKYSLISRDIIADSIETVVNAQFYDAVVPVVGCDKNMPGAIMALGRLNRPGLMVYGGSVKPGKWKGEDLNIVSAFEAYGARMQGNMSDEDYKGIIKNSIPGPGACGGMYTANTMASAIEAMGMSLPFSSSNPAVSDEKQTETQKVGAAIRNLLEKNILPRDIMTKEAFENAITTVMILGGSTNAVLHLIAMARSVDVNIGLDDFQRISDKTPFLADLKPSGRFLMEDLHKIGGVPGVLKLLLKEGYLHGDCMTVTGKTLAENLAEVPDLHDDKGLMYSFDKPIKAKGHLQILYGNLAPEGAVAKITGKEGEVFEGPARIYEDEFDAIRGIQEEVQKGEVIVIRYSGPKGAPGMPEMLKPTGAVMGKGLGKDVALITDGRFSGGSHGFVVGHITPEAQEGGPLGLIQNGDIIRIDAITNKLEVKLSDEELEARRKAWNKPPYKATKGILRKYINSVKSASEGCVTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ1</accession>
    <name>A0A654DYJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized oxidoreductase UxuB</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uxuB</name>
        <name evidence="1" type="ORF">MARINOS108_11761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="29006" checksum="47D7804320AA6A31" modified="2020-04-22" version="1">MNLFDLSGKVVIITGGAGVIGSTLARSLAEAKCKLVILNRDQTKIDQRVAELKKITPDVMGRVCDVLNVKELEETNKLILDEFGRIDILINAAGGNIPGATQSHDQQIFDLKIEAIDQAMDLNLKGTVYPSLVFGRSIAENGSGSIINISSMATYSAITRVLGYSIAKSGVNTFTRWMACELARKYGDKVRVNAIAPGFFIGDQNRELLLNPDGSLTDRSKKVINKTPMGRFGEIRELAGAVQFLCSDSASFITGVVLPVDGGFSAFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK8</accession>
    <name>A0A654DYK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="27572" checksum="56EA7C9CA205CF70" modified="2020-04-22" version="1">MMSLFEYLLLVLAGIGAGFLNVVAGGGSMLTLPLLIFLGLPPAMANGTNRIAILWQNVFAINKFRRAGIIDYPYSIYLGLAAIPGAVLGGFLAVDIRGELFTRILSIIMLAVGLMIVFGSARKPISIHTGGERRSPWVGILIFFLIGIYGGFIHAGVGFIIIFVLDRLHHYPMVRINSIKVIVAFVYTLAVVMVFIYNDLIQWRYGLTLAVGTSLGGWLGSLFSIKKGDKWIKALLLVTIVVLSVKLWFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ2</accession>
    <name>A0A654DYQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="39157" checksum="FEF1D0F9A5B94E81" modified="2020-04-22" version="1">MHTHILPEKLPNFAEKFGYGEFISLLHHRQGAALMMKGDKFFREIEENCWDPKVRIREYEKFNTKIQVVCTIPVMFSYWAEPKDCLNLSMFLNDHIAEVVAKHPKHYIGLGTVPMQDVDLAIGELERMKELGLPGVQIGSNINQHNLSKPRFFEFFEACEKLDMAVLVHPWDMMGKADMEKYWLPWLVGMPAETARAVASMIFGGVFARYPKLRVCFAHAGGSFLTTIGRLERGFECRPDLVAVHNNVNPREYLGKFWVDSITHDPMLLDYVIKLVGSDKVCLGSDYPFPLGDLEIGKFIEEMNLPEEDLENIMYRSTLDWLGLGSKEEDQKVLSSFKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY2</accession>
    <name>A0A654DYY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024790658" evidence="1">
        <location>
            <begin position="20"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="2">
        <location>
            <begin position="396"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="832"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="911" mass="100519" checksum="E76EAD10CCFA6E30" modified="2020-04-22" version="1">MRKHLFYLFLALSAYGSIAQNTAHNDWDLLDKSVRRGHWSWRNLGTSSPQVQDSYLDFCANKSISDVYMFCIPEWQWSSSLKDDSEIGSLAYQDSLAAFISKANARGVKVWALYYNWAFIETDEEGNYLYRPDGSLKASVDTMGNVPNNEHITAANQIMDAIGKFNQRHPNAGFHGVQFDQEPKSERFHVPYLDYCKTATQRADAWNEVLKSQGARPFYHSAALRPSWVSYETITYEGEDNYVAYHYIKNAHHAAMMNYTSNNNNFIFFGSRLLHWADSLPGKKFVSVGIETDDILGLWEGSEYETYADEIYAENDNTRFNLFESDMDSAQGVFEQYASFDRIAIHSDGYIEHWFDGAEIDSVGPTPGGTSFVDLTVDSSPNANAGWWDTGTNQFNLLDNGGFEDGDSPWVWGYLGNGRISSNAQSGSYSGKIVYDNQVARTVTGLKPNQQYVLSVSLKAASAGSVSYIILEDYDGASAYQSTTVNAGTTYQTQSVTFTTGDSDNSVDLLVYNESPGNDLFVDDFVLKEVQNSPGLAVANLGFEEGDSPWAWGYLGNGRVAENAHSGTYVGKVVYDNQVLRTFGGLMPGTTYKVSAYLKTSSPGGTAYLIASDFDGGSSQISVTASTDSLYNVFQNTFTLGASDTSVQIAVYNESVGNDLFADDFEIIEIEGPMEYQYDNMSFEEGDSPWVWGYLGNGRVSGNARTGTYAGEIVYDNLVQRTFTGLQSNTEYTISAFAKAASTGSIGYLIVQDYDGTTSQHSVTINAGTSYSLIQNTFTTGANDNSVVVVVYNESPGNNLYVDDFELVEGSGSARNADVVPIPSKEVAALTIYPNPADNFLRIDLEIESQIHDLMIYDINGKVVLIKDGEDFTSLEVNQVDISGLKNGMYMVSVILKNGEQIGRKLVIHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY8</accession>
    <name>A0A654DYY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-succinylornithine carbamoyltransferase</fullName>
            <ecNumber evidence="2">2.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">N-succinyl-L-ornithine transcarbamylase</fullName>
            <shortName evidence="2">SOTCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">argF</name>
        <name evidence="2" type="synonym">argF'</name>
        <name evidence="6" type="ORF">MARINOS108_110059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-succinyl-L-ornithine to produce N(2)-succinyl-L-citrulline. Is essential for arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
            <dbReference type="ChEBI" id="CHEBI:58862"/>
            <dbReference type="EC" id="2.1.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. SOTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.11" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02235">
        <property type="entry name" value="SOTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043696">
        <property type="entry name" value="ArgF'-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="4">
        <location>
            <begin position="182"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="2">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>N(2)-succinyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="35177" checksum="7364CA70D5A1AA6B" modified="2020-04-22" version="1">MRHFTSVNDVKDLDGFVQKALALKKSPFAHKHLGENKTLGLLFFNSSLRTRMSTQKAAANLGMNTMVMNVTQDSWQIEIEDGVVMDGGKAEHIREAAAVLGQYCDILGVRSFPALRDRKADYSEKIIKAFIQHSGVPIISLESATLHPLQSFADLVTISEFKKSPKPKVVLSWAPHINALPQAVSNSFSQWMTHADVDFSIVQPKGFELSDQFTKGAKIYYDQEEAFEGADFVYVKNWSSYKNYGEVGNYPKWMIDQSKLANTNHARVMHCLPVRRNVVIADEVLDSKSAIVIHQAANRVFSAQAVLKEMLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ02</accession>
    <name>A0A654DZ02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1267" mass="140680" checksum="919741F6665557CB" modified="2020-04-22" version="1">MLNQIIKYFLENRLVTVLILIMLVAWGIVTSPFSWNTGFLPKDPVPVDAIPDIGENQQIVFTQWPGRSPQDIEDQISYPMTTYLLGIPGVKSIRSSSIFGFSMINIIFDEEIEFYWSRSRILEKLNSIPSGLLPDDVRPTLGPDATALGQVFWYTIEGRDKEGNVTGGWDLHEIRTVQDFYVKYGLNAVEGVSEVASIGGFVQEYQIDVNPDALKAYGIPLMKVMDAVRKSNRDVGAKTIEINQAEYLVRGLGYIKSVADIEKAVVSVQDNVPIRIKDVAVVSLGPAARRGALDKEGAEVVGGVVVARYGSNPLEVINNVKAKINEIAPGLPKKTLTDGTESQLTIVPFYDRTQLIHETIGTLETALSHEVLISIIVVLVLLLNLRASIIISSLLPVGVLMTFIVMRYTGVDANVVALSGIAIAIGVMVDVGIVFVENIIRYLEMPENHGVKGKDLLRVIYEATKEVASAITTALATTIVSFVPVFAMESAEGKLFKPLAFTKTYALLGSFVLGLVVLPTLAYFIFGIRYDKKNVRNIWNFTFITAGILLVVYTQMWLPGVLCLIGFNNMLESKWPERFKKFPEYINIALALFIASFFLAEEWMPLGVQTSLTVNYLFVLGLIGIILGALLSVVHFYEPILKWCLVNKGKFLLLPFFTILLGVVIWIGFGKSFGFLGDGIKETQAWKSLDKTFPGIGSEFMPSLNEGSFLLMPTSMPHAGMEQNRRVVGQLDMLVAQIPEVEMVVGKLGRVESALDPAPISMYENVINYKPEYVIDGEGHRKRFKVDGKGNFILKSGESLSNEEILAANISTSDLLPDLKGQYFRNWRESIKSPDDIWDEIVRVTKIPGVTSAPKLQPIETRLVMLQTGMRAPMGIKVYGPDLKTIQDFGFQLENILKDVHSVKSEAVFADRIVGKPYLHLNINRNEIARYGLSIEDVQQTIETAIGGMKITSTVEGRERFPVRVRYPRELRDDPESLGNILIPTPTGAQIPMKQLVDFEYVRGPQMIRSEETFLVGYVLFDKRAGFAEVDVVKASQEAILGKIDSGELIVPAGISYKFSGTYENQVRAIKRLSIVIPISLIVIFLLLYFQFKTVIASSIHFSGVFVAFAGGFIMLWLYGQDWFLDFSISDTNMRELFQMHPINLSVAVWVGFIALFGIATDDGVIMGTYIHQVFEERKPGTIPEVRAAVLEAGKKRVRPAMMTAAVAIIALLPVLSSTGKGSDIMVPMAIPTFGGMAIQIMTMFVVPILQAFWRETVINNQNRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ29</accession>
    <name>A0A654DZ29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18920" checksum="9DA125D77F398892" modified="2020-04-22" version="1">MTEKEFITAIQNHTGIIHKILYLYVDDTEDKRDLKQEIQLQAWRAKDRFRGDSQFSTWLYRVALNTVFTFNRKRKISSTSLDSAAEPIHHLAEKTERSELLLRAIKNLNDVDKTIITLHLEDYDNGEIADITGLSKNNVGVKLHRIKEALRKKLNEKAQWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE4</accession>
    <name>A0A654DZE4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alginate_exp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024893671" description="Alginate_exp domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="2">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="46991" checksum="5BE89BB9900A546F" modified="2020-04-22" version="1">MKKTIYLIALIVALTCVEATAQMTISAEVRPRTEFRNGFKTLTEDSKDASFFTEQRSRLYLDYADSAFKFRVSFQDIRIWGETTQIFKEEYGKTFLSEAWGQYYFTPSLSVKVGRQIISYDNQRFLGGLEWAQQGRRHDALLLMYEQNKTKLYFGLAYNQDDDVPEQAFLQAPGAGYYSVGGSYKTFQYGYFNKGFENGSLSLLAFNAGYQNPDTTVSFKQTWGVVASKKLAGISLAGDFYYQTGELGKNKVNALLAGINATFTTPITPLTFGVEYISGKDDDDTSSDITAFSPDFGTNHAHNGYMDYFFVGPANGSVGVTDLYLKTSFNVAGGALKTNIHQFMTGSTQLDTEGQELSKTMGTEVDLVFIKKLKGGVVWNLGYSQMFASDTMEALRGGDKSALQCWAWTMITFKPTFFTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI7</accession>
    <name>A0A654DZI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1,4-beta-xylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024981833" evidence="3">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="90"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="42193" checksum="1C4A86121E45BBEA" modified="2020-04-22" version="1">MIKSKPSNLLFLLTILVVFACSTPKEQSKESIEKPVVRAVWSKEQANQWYEKWGWLRGANFNPSSAINQLETWQAESFDLETIDRELGWAADIGMNSMRVYLHHLAWEQDPEGFKNRMEQYLKTADGHGIATMFVFFDDCWNNTYAAGPQPEPKTGTHNSGWVQDPGQLIYDEPQLSEQLEAYVKDVMKHFADDERIVLWDVYNEPGNSGYGNRSMPLLTSIFQWGREVNPSQPLSAGVWNSSLTDLNKYQLANSDVITYHNYEDSAHHAAMIDTLKQYGKPMLCTEYMARTRNSTFADIMPMLKAHNIAAYNWGLVAGKSNTIYAWDTPIASGEEPEVWFHDIFRKDGSVYSQEEVDLIKELTVSSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL8</accession>
    <name>A0A654DZL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="143" mass="15836" checksum="32467CC4847D58E6" modified="2020-04-22" version="1">MSILKDLKNFVTGGAAKVDLAYDKEVLSHGESLQVSVTVKPVDETLIFEKIYLRVKAVESSAHSTTIYSEEKLIAENFQISAGEEKTWNTEVSLPESAPATYIGRHSSLHWSAQAGVELPGVNPTSDERRFVVNKRMVYPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E046</accession>
    <name>A0A654E046_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein ExbD/TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17602" checksum="D5C41B1B14BF958C" modified="2020-04-22" version="1">MSKFKKSSNTQQEIPTAALPDIIFMLLFFFMVTTVMRETDIMVKQQLPRATQLTKIERKSLVSYIYIGEPKNTAQYGNEPKIQTNDVFVEANEIVQFVSQEKDKLSEVERDQITMSMKVDVEVKMGIVSDVQQELREANARKVLYSSVKKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E048</accession>
    <name>A0A654E048_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsI (Penicillin-binding protein 3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_110116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="643"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD15963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="699" mass="78539" checksum="BECAD11F92698239" modified="2020-04-22" version="1">MSIKKAILLRVRIAFMLVFLFSAGILFRIITVQYAEGDKWRGYAETMGLQVMKVNATRGNIYADDGSLLATSLPFYQVAFDPYLPGKELYNAHIDSLCYLLSDFYGDQSPAQYRRKIDAARKERKRYMVLNRQEVGYQEKKMIERWPIFREGRLTGGIIFEKVEKRFLPFSHLGYRTIGTVNSDNRGVVGLEYSFNQELGGQNGEALFQKMAGGGWKPVYDGSEIRPKDGYDIQTTLNVNLQDVTESALYKALQRHQADYGAVILMEVKTGEIKAISNLSRNSKGEYYERYNYAVGSQGAREPGSTFKLASMIALLEDSNIKLTDTIDTGNGVMKFFNETMRDHKPGGYGILTVKEVFEKSSNIGTAKLITRHFGDNPSRYTDYIKNIGLDQPLGFQMVGEGIPYIKDPSDSTWSGISLPWISHGYELKMTPLQTLTLYNAVANNGKMIQPIIVKAVKKANRNIEKYEPKVLNAKICSKSTLRDVRLMLEGVVERGTASNIYNEKYKIAGKTGTAKKVVNGRYTNAYYTSFAGYFPADDPKYSCIVVIDDPKGYQIYGSDVAAPVFKEIADNIYALETELHQELPDQRTQFAGIFPVIRSGKQDELKMIANEFGISNHSQTDASWVTTDVVNHSVFWEDNTPKAERIPDVRGMTLRDAIYLLENAGLKVSVQGRGRVARQSIVPGTKFSKGTNIKLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E095</accession>
    <name>A0A654E095_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GH3 auxin-responsive promoter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="519" mass="59424" checksum="3F641D0D448E6633" modified="2020-04-22" version="1">MAILGTLLKKGIMLGESMEQQYTSAFDLQKGELRKLMIHAQHTEFGRHYGFANILKTFKTGSRDQFYAEFISKVPVFDYDKIHNEWWHLAKAGKRDVCYPGKVKYFALSSGTSGASSKYIPITKEMIKSIRKTSMRQILTLSKYDLPTDLFTKGILMLGGSTNLRKSGTYFEGDLSGITAAQIPFWFQHFYKPGKKIAKTSDWGDKLDEITRRAKDWDIGIIVGVPAWLQILMEKIVKHYGVATIHDIWPNLKIFVHGGVSFEPYKKGFEKLLKHPLIYMETYLASEGFIAFQAQSVQRSMKLVLNNGIFYEFVPFTPKNFTEDGVMRENPETLHIDQVKTGVEYALLISTNAGAWRYLIGDVIKFASVEDSEIYITGRTKHFLSLCGEHLSVDNMNKAVELVSAEFNIDIREFTVLGESVGGRFAHRWYLGTDDTVDEESLQKRLDLKLMELNDDYKVERGHALREVTARVLPTALFYEWMKEQGKEGGQNKFPRVLKNEKSQQWKEFVAARNIMNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A2</accession>
    <name>A0A654E0A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydfG</name>
        <name evidence="2" type="ORF">MARINOS108_120319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="27051" checksum="3838AA1DFA57661D" modified="2020-04-22" version="1">MSKPIALITGATSGIGEATARCLAKDYRLIICGRRQDRLTKLEKELAEETEVTTLSFDVRDRLAAETAISGLPAKWQSVDVLINNAGNAHGLSAIQDGQVADWDAMIDINVKGLLYVSNAVIPGMVSRQKGHIINIGSVAGIEVYPKGNVYNASKYAVDAISKGMRQDLITEGIKVSEIKPGLVQTEFSAVRFKGDQERAEKVYVGFDPLQAQDIAETVTFILSRPAHVNIADMLVLAGAQASATMVHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G6</accession>
    <name>A0A654E0G6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">nuoN</name>
        <name evidence="9" type="ORF">MARINOS108_12094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="122"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD14735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="478" mass="53135" checksum="F2A24D3BCFA65F7F" modified="2020-04-22" version="1">MLTNQLTNILDSLGGLSFEISLAAGALILLMAGLVWKQTLVSRVIYVVVILVAMWLVQVDGVSGFLFDQTLVTDSMGQIMKLLFGVTSLWIVFFPTAERHRSEYYFLILSLILGSTLMLSVNHLLVIYLAVELTSFSAYMLTNFNFRKGAFEAGMKYLIFGGVTSALALYGMSLIYGFTGTLSLSEMDLHLTGDPVLLNVGILLFIGGILFKVSAVPFHIWVPSAYQEAPTDAVMVLSVVPKLGGFVLLHRILMTVGVQELYWLYVTISVIGIFTIVLGTLGALGQTNVKRMIAYGAIAHSGFILVTLLIPFENGAVAFAWYAVVYAMMNVAVFYLVSVFEIHGKTEINHFSGLSKTEAYMGGLMVVVMIALIGLPPTVGFTAKFYLFTVMWDWYQQVGDPVMLTYLIVAILSVIFSLFFYLKIPYFFFLKQEISDLQVGIPVSQRIIATIFTSGLLWFFFRPEILNNIAEIIKFLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X0</accession>
    <name>A0A654E0X0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secY</name>
        <name evidence="11" type="ORF">MARINOS108_120477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="440" mass="48098" checksum="8E9EB94D463E367B" modified="2020-04-22" version="1">MKKFIQTIKNIFSIEELRIRILNTIGFLIIFRLGSFVVLPGVDPAQLTGDAGGIFGLLNTFLGGAFSRASVFGLGIMPYISASIVLQLMTVAVPYFQKLQKEGDSGRKKISQITRVLTIFICLAQSIGYLTATIPSEAIVLENQFLFQISSMVILTAGTIFCMWLGEKITDKGIGNGISMLIMIGIISRLPASLWYEVVEVKGLPGALLSILELVALFLVVMATVALVQATRRIPVQYAKQVVGNKVYGGQRQYIPLKVNSSGVMPIIFAQSLMFLPALLAGIWSQDSDIAQYIGTTFSDIQSWQYNLLFATLIILFTFFYTAITINPNQIADDMKRNGGFVPGIKPGKQTSDFIDNVLTRITLPGSVFLAVIAILPAFAMMAGVSTTFAQFYGGTSLLIMVGVILDTLQQIESYLLMRHYEGMMKSGRVKGRTQNTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E168</accession>
    <name>A0A654E168_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="60" mass="6773" checksum="4434148EA2803A86" modified="2020-04-22" version="1">MTDFTSLELRHSLNTIPPIIPVAPVIMILFIEPIIEHFLVGFRFSDKIDAFGRVIGTHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E172</accession>
    <name>A0A654E172_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="235" mass="25325" checksum="9C0B1F60958287BB" modified="2020-04-22" version="1">MKGKILCTLSIIGWLMSGCGSQNKPATNEGASAVGNQSADAKVDQKEVPVILFFGNSITAGYQLDVEDAFPALIQDRLDSLGYQFKVINAGLSGETTSGGLNRIDWVLQTIPDVFVLELGANDGLRGLDLEETKKNLLLIIDKVKQANPEVKILLAGMRVPPNLGKDYTTRFSGIFPAVASETGASLLPFILDGVAGNPELNLPDGIHPTEEGHKILAENVWRVLRPILEEFQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C8</accession>
    <name>A0A654E1C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="27161" checksum="4BD4468F8532BF8B" modified="2020-04-22" version="1">MRTLISTILLISLFSCSESQEIQFRSMVIHTLRPQVLHEWYAEHLGFEPVHKQSLLRDDFTIHFKSPEELMADAPDYRHGFFKIGFLTDEFDDLFESLQQGQVEFLGGIFKDNNLSRRSFLIKDPDGNRIQFFETKEQGGLQPYFLALLTPSIGEAEKWYQMRFPVTKTHNLDLREKKIYIRLLEGEDFAIEIIENNDQVSPRTLGPGFHQFEIGGIGTPFEKDKDGNNIISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E6</accession>
    <name>A0A654E1E6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">MARINOS108_140114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="66" mass="6212" checksum="7182609FA456A36B" modified="2020-04-22" version="1">MGAIGAGLAVLGAGLGIGMIGKGATDGIARQPEAAGKIQTAMIIAAALIEGVALFAAVIGFMSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G7</accession>
    <name>A0A654E1G7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_140134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="439" mass="49666" checksum="F5A32D7041198780" modified="2020-04-22" version="1">MIPQLAFVAVLLFFGFFLFRRIARIRKNILLGRPETINDQKGVRLKTLLLVAFGQKKMFKRLLPAFFHLLIYVGFILINIEVLEIILDGLLGTHRLFAPFVGDFYTFLISFFEVLAVLVIFACVVFLIRRNILKINRFHKIEMRGWPTLDANLILVIEVVLMVAILSMNAADQVLQARGVDHYTVTGSFVVSSMMMPIFDGLSDGGLIMVERSAWWFHIVGILAFAVYVTYSKHLHIFMAFPNTYYSKLTAKGKMNNMEEITNEVKIMLGMSTGAEAAPPPEGMKFGAKDVNDLSWKSLMDAYACTECGRCTSECPANLTGKKLSPRKIMMDTRDRLEDVGLSLQKGGEGLNDGKSLLGDYITKEEINACTNCNACVEACPITINPLDIILQLRRYVAMEESGAPQSWNMMFQNVETNFAPWKFPPTDRFKWAEDLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I2</accession>
    <name>A0A654E1I2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TonB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_20035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
            <orientation evidence="1 9">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="146"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25445" checksum="805D3EA4EA95B6CF" modified="2020-04-22" version="1">MEPKKNPNVDLTRKSGLFMNIGFTVSLLLVILAFEWRTYDDSGLVDLGQVTDDFEDIMEIPPTEQPPPPPPKIQLPQIIEVPDEEEIEEDIEVELDVEVTEETVIEDIIFEEAPEEEEIEEVFTIVENQPEFPGGMAAFYKYVGDNMDYPSQARRMGIEGRVYVQFVVDKDGTVTEVKAVKGIGAGCDEEAERVLRQAPKFKPGKQRGRAVKVRMVLPIIFKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J5</accession>
    <name>A0A654E1J5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ORF">MARINOS108_140164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="373" mass="42909" checksum="488C4D07A2E8D539" modified="2020-04-22" version="1">MEFILNFLIWSSDPDIFVIPILDHPVRWYGLLFAGGFIVSQQIMFWLFKQEGRPEKDVEKLTVYMVVAVVVGARLGHCLFYNPGFYLSNPIEILKIWEGGLASHGGALGIILAIFLFSKKYPQYPMLWMLDRLVIVVAITGAMIRTGNFFNSEMEGKMTNANYGVVYARFTEDVLRYDDRKVEDVIFLKGGERVSNTPGIHPITAKIIYQRGVELTAQDKVFFENQLRSALLRYDDVVEHIDFGKDEPLAFKFYQEDNRSVAEIYGLGVSRHAAQLYEAGYCILLMLLFFWLWKEKRFILPQGFSFALFMTLLWSLRFVDEFFKLNQEAFEEGMVLNMGQLLSIPLVLSGIGMMIYFHMKGSKTMSGDDRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K9</accession>
    <name>A0A654E1K9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">MARINOS108_120500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="701" mass="77643" checksum="149EE551BB3DE9B8" modified="2020-04-22" version="1">MARDLKYTRNIGIAAHIDAGKTTTTERILFYTGVTHKIGEVHDGAATMDWMEQEQERGITITSAATTVFWKYKNDDYHINIIDTPGHVDFTVEVNRSLRVLDGLVFLFSAVDGVEPQSETNWRLADNYKVARIGFVNKMDRQGADFLNVCRQVKEMLGTKAVPLQLPIGSEDKFQGVVDLVSNTGMVWNEEDFGMTWSEVPIPEDMLDEVAEYRQALLEAVADYDETLLEKYFEDPESITEDEIIAALRAATIDLAFVPMLCGSAFKNKGVQTMLNYVMELLPSPLDRDNITGTDPDTEEKISRKPSESEPFAALAFKIATDPFVGRLCFIRSYSGLLNSGSYVHNMRTDKKERISRIFQMHANKQNQIDALHCGDIGAVVGFKDIKTGDTLCDEKHQIILESMVFPEPVIGYAIEPKQQADVDKLGMAISKLVEEDPTLQVETDQETGQTILRGMGELHLDIIIDRLKREFKVEINQGAPQVAYKEAINTTVEHKEVYKKQTGGRGKFADIVFELGPVDEDFTGEGLQFQNDIVGGVIPREFIPAIEKGFKEAMKNGPLAGFPLDSMKVRLFHGSFHDVDSDALSFELAARAGFRAAASKAKPALLEPIMAVDAVTPDEYTGSITGDLNRRRGMMKGMDTKGTSQVVKADVPLSELFGYVTDLRTMSSGRATASLTFAHYAQVPAGIADAVIKKTKGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N4</accession>
    <name>A0A654E1N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="112" mass="12946" checksum="D26CE2E3924A5E99" modified="2020-04-22" version="1">MLFLFLSPGSSKADTWFFVGEDKVAHLGIFLIWSFLVVWSFERSHLSLKAFFWVFSGALIFGLMTEWIQGYVPYRSSDLMDFMFDAAGAVLGLFLAYFMKKELNLADKKFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q9</accession>
    <name>A0A654E1Q9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024798314" description="Cellulase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="855" mass="95641" checksum="4938F82B3C843CD5" modified="2020-04-22" version="1">MIKSVVLSLALTLGLGISASNAQNKNVYVDDSGIMRWGDSDKEVQGFGVNYTVPFAHAYRSAEKLGVDKKEAIDNDVYHFARLGFDGYRIHVWDTEISDSLGNLLENDHLDLFDYMVKKMEDRGMKMLITPIAFWDNGWPEPGEDTPGFSNKYGKNACLTNEDAIAAQENYLYQFLNHTNPYTGLAYKNDPAVVAFEISNEPHHRQEADSVTRYIKKMVTSMRNTGCEKPIFYNISHSIHLVNAYFDAGVQGGTFQWYPTGLGAGEELEGNFLPNVDLYEIPFAKNSKFKKAAKVVYEFDAADVGRSYIYPAMARSFRTAGIQWATHFAYDPTYLAYANTEYNTHYMNLAFTPQKALSLKLAGEVFHRVPVYKDFGAYPENTQFDGFRVSYEEDLAELLTEKKFIYTNTTKSIPPSPTRLNEVAGYGNSSVVEYAGAGAYFLDQLEKGVWRLEVMPDAVWVEDPFGKNSLQRKLGEIRWGEWPMTIDLPDLGADFVLKPINEGNGWRPAVAGKRFIIKPGTYLIARSGVKTKLQGVEKWKNITLNEFSAPMSTLEKQYVLHEPAAQISQGSPYEISATILAPSQPERVEVLAYIGWRPKTYVMENNGYSYMATIPAEDIKAGFFSYFITVKGQLGTQTYPGAVTGLPGDWDFEDNNAYVVKVLSNDSPVYLFDALADNDKLSRTWSPQSSFVPLAEAGKAEIRIKVARLKEVDAENPNGEQVADYSMRYAFKEKVSGRAADLVGKRELVLTGRSLTDEPTIVQLALVAADGKTYGGLLELGPKLADYRLSLDELKEVKMVTLPRPYPSFLPYYFEGASRAAFDIRKAEVLQISVGPGIQEVEKPQALAIVSVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C8</accession>
    <name>A0A654E2C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="413" mass="45509" checksum="50A64C2ABB8D9873" modified="2020-04-22" version="1">MKSVITLYKNAFGGLSPAAWMLALVILINRSGTMVIPFLSVYLTSSLGFSLVETGWIMSMFGLGAIGGSFLGGWLTDKIGPFKVQLISLLGGGLMFLALSQVTSFYPLAGFIFFVSLVSEMLRPANQIAVSYYAKPENVTRAFSLNRMAINLGFSFGPALGGLLAAVSYQWLFIADAITCAGAGLIFFLYFYGKQGKEKEPLPDTNTALIPDKSVWSDGLFLGFILLVICFSTMFFQLFSTWPIYHRQVYQLPEQEIGLLLGLNGLIVFLFEMVLVYKIGDRFPIRRLIAFGCFLMALAFLALFGMESKAALYLACIFISFAEIFAMPFMATYTVQRSGKRNRGAYMGLYSVAFASAFVLAPLIGTNLVDALGFQNWWLIAGVFALATGFLFYWILSEKRGVNHLEVRKNAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E0</accession>
    <name>A0A654E2E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SusD/RagB family nutrient-binding outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="517" mass="57351" checksum="4592E9EC072BD011" modified="2020-04-22" version="1">MKNLLYIVLTTVAVAFTGCTSDFEDINTDKNKVAKESYVPGYHLSRAQLEYTGNSDFSYDTWRINIIYSSMMTQQLANASWYAGDKYMQNDGWANASFDVAYNDQVKYIVDLLKITETDPLYANLHQIARIMKVIIFHRLTDLYGEIPYSEAGLAYHEGIYAPKYDTQEFIYMDMLKELKEAAEALNANGDLPGSGDLIYGSAADPIGQWKKLAYSMMLRLSMRLTEVAPTVAKQWAETAVNGGVFTSNADNAFIMHDAAGGRTTVNRNSNILAGEWNATNTGEVFLSKTFVDFLSDTNDPRLGLFARIQSTGDTDPANQIGLPNGLDQNGGAFDVSTDPDFPGDITNYSTIRDDVFLSLSGPTFVINYAQVELLLAEAALRNYSVGGTAESHYTAGVTAAMQFLTQYNSTAEVPADEITTYLAANPFVVADGMEMIGAQYWVASFLDWYEVWSNWRRTGYPELVPVDYPGNATGGVIPRRMIYPSHEASNNSVNYAEAISRQGTNTFLTKVWWDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E8</accession>
    <name>A0A654E2E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="112" mass="12603" checksum="04F97AFC7FC2D5F4" modified="2020-04-22" version="1">MANTGENFRTDIDRDYFKGILNAFVREMPEKLRFLALASRHGDFAEVGFIAHHIAARCEVIAANEISATARQLEVEANSHSSNVSHSVRSLVNDMQKFMQQMGYDMADQSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J1</accession>
    <name>A0A654E2J1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_12008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="200"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="38124" checksum="E73CDC9BE0653AA4" modified="2020-04-22" version="1">MAKINFGGVEEEVVTREEFPLSKAQEVLKGETVAVLGYGVQGPGQALNLKDNGINVIVGQRKDSKTWDKAVADGWVPGETLFELEEACERGTILQFLLSDAGQIALWPTVKKYLTPGKALYFSHGFGVTYKEKTGIIPPADVDVILVAPKGSGTSLRRLFVEGKGLNSSFAIHQDATGKAKDRVVALGIAVGSGYLFETDFYKEVSSDLTGERGTLMGAIQGIFRAQYEVLRANGHSPSEAFNETVEEATQSLYPLIAENGMDWMYANCSTTAQRGALDWMGPFYEATKPVFEKLYKSVTDGIEAQKSIDSNSQPDYRVKLEAELKELEESEMWQAGKAVRKLRPENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S8</accession>
    <name>A0A654E2S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="36570" checksum="63CC43B00253F13F" modified="2020-04-22" version="1">MLSICIPTYNRDQTVKRNILHIFEILAKNGLEDLVSINVSDNNSQDKTSDVLDEILNTYTPKFHFRVHHHTRKLKIQDNLIYVAAMSKTEKFMWLGDDDFFSEDYLLKVIELITTDKNVSGIIPAFKEVGISGEELSGSRDLGKESKIYSPGFATCLKMSWRGHQMSGLVFDRHILEYYQKNEVSNMYPFIFFAAFASLHGHIFHLTEFPIEVTQPGQEKKDWGYDQDGLFNEVFDNYSKLEVGMLRKTLLQLYFYYQQFGRLLAYKRNGFRGVMKAYIKVEFSKNGTFLFKICFPLFAVTHIIFLKIREYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V9</accession>
    <name>A0A654E2V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024883740" evidence="2">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="34967" checksum="12CEA94964782613" modified="2020-04-22" version="1">MKKLTLTICLSILALMGYAQVTELHVHGDQTSNRISQSGGTYTELAQRTWSGSAGILFSAYASDTYVNGGLSTTGNTKYKFNPSVFGSTSHGAKMIYTNHSSIGFFISPASTAAGDDVIWGDPVLWLMRGGDVGIGTIQPNAGLHVQNKDLLISNDVSTGGTGISKLIFSEGSDDTAPLGFSINYNGDNFTGGDNKLYFESPTAGEVFTIRNDGKVGIGTASTGSHKLAVNGSIGAREVKVEAGTWSDFVFEQGYSLRTLEEVEEHIARNGHLPDVPNEAQVTESGINLGEMDALLLQKIEELTLYLIEQNKKIEALQNELSVLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z3</accession>
    <name>A0A654E2Z3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15355" checksum="CD87C1B85469C745" modified="2020-04-22" version="1">MPRILALDYGAKRTGIAVTDPLGIIATPLETVRSHDLMDFLKAYFEKEEVSEVVMGMPKNTDGQPTNATPLVEAAVNRFKKLFPDKKLFLHDERFTSKMALDAMIAGGTKKSDRQKKENIDRISATIILQSYLEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E316</accession>
    <name>A0A654E316_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">selD</name>
        <name evidence="8" type="ORF">MARINOS108_20473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="48"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="167"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="35898" checksum="B85ED15499ECDAB2" modified="2020-04-22" version="1">MEYKLTQYSHGAGCGCKIAPEVLDKIISTDGQPMPFFKNLLVGNESKDDAAVYDLDGTTAIISTTDFFMPIVDDAFDFGAIAATNAISDIYAMGGTPIMAIAILGWPIDKLPIEVAGKVLEGGRKVCADAGIPLAGGHSIDAPEPIFGLAVTGRVPVTQVKKNAAAKPGDLLYLTKPLGIGMVTTAQKKGLADTKDLDLAKHTMLQLNKIGQELAAFEGVNALTDVTGFGLGGHLLEVCEASGCAAQIDLSKVPRFDFVQKYLDLNCTPGGTNRNWKSYGHKITLAEGMDHRLIADPQTSGGLLVTVSADAQQAFESFMQERGFDLEAFGTLAEGTGVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E338</accession>
    <name>A0A654E338_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025034999" evidence="1">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="27456" checksum="CFD713DE2230B4A1" modified="2020-04-22" version="1">MVRQFFIVILVLTSQALMAQEGKDILRKHFKAHGQDLWKEMNSVIVDGKWVDADYHSYPMKLTYKYPGKIRLEGTYQNKRFAEATDGQLSWIIAPWKPRYEVQLMSTAEEIVIKNSFSRGSPLYPVKDHLTFLGLSDMEGILYYTYLMEEASFRRTFYIDQKDFRLYYEKIESKFDGTPISVLKTIEKYKQYNGLLVPTAVYFKGDDFERELVFDEIYVGMGANDDLFQMPNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E0</accession>
    <name>A0A654E3E0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ORF">MARINOS108_20450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="79" mass="9034" checksum="E5FFE3C208686DE2" modified="2020-04-22" version="1">MSKVCEISGKRPRVGNNVSHANNKVKRRFNPNLQKKRFYIPEEDKWITISVATSMLRTINKNGIYAEIKKARAKGTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E2</accession>
    <name>A0A654E3E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LPS export ABC transporter protein LptC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="22898" checksum="270D2C11D04F163D" modified="2020-04-22" version="1">MKEDQRINSLKKYDQTVMVVTHDRFFVWGIALIGILVALGACQNRKELIDEPLYDGPLVIMDSINTKMSDSAKVILRLKAAKQLNYEGGDREWPEALYLEYLDDDGQVVSTFRADYVYYTAKDNLYRAEGNVVVKNIEEGDELNTEELYWSPKDEQFYTDRFVTIQSDDEVHTGEGLTADQDFTSYKILKPQGTLLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F4</accession>
    <name>A0A654E3F4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="151"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="713" mass="80841" checksum="A09EE876156479A4" modified="2020-04-22" version="1">MSNFYDFDEIRNLTIGTIETVSPLEIKVLLEVDAPQNVAINTGVPTHFPKINGYVLIPNETGAIVGVINWIGVQHSNYPIRKGFKDFDLIDLPFPLRKMIITPLGVLKKKKDHTYEIERGVYSYPSVGDNVILPTDRQLSAIVENPDGKFEIGKAPIAGNAPIKVNPDKLFGRHLAILGNTGSGKSCSVAGLIRWSLTEADKVKTNAQLNSRFIILDPNGEYFDSFNDLGSKRVRKFTVKLDEDDTSFEQLKIPAWMWNSQEWISFSQAAPGAQRPLLLQSLVDLKQGSKLKESILIRISSFLNSRKNLLITYLSDLPTSEASYARFMGFIDNLNNFRTDIQEYSNGLETGDFKSSFDLVFDELDKLLSSKRKQSATGSTYYVGFSNTNIENIITKIDEALEKLVFSDVNSSTINADTPIQFQLPDLIPYLEQLAENQGGHILQFVQMLSLRMRFLFSDERLNGVVQPEEDITLIDWLNQYIGSNEAENGQITLIDLSLIPSDIIHVVVAVLSRLTFEAIQRYRKIYKKELPTTLVLEEAHTFLREFHNNTNNICLETFERIAREGRKFGLSMVLSSQRPSELSQTVLSQCNTFLLHRIVNDRDQDLVKRLVPDSLSGLLKELPILPSRKAILVGWAFPIPVLVEMKFLDKEHRPQSNDPNFWDVWTGNEKREIDWTKIANDWQGIKSASNDDIQPESNNEEPDTMDEDDPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K0</accession>
    <name>A0A654E3K0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="347" mass="37425" checksum="64690D65B325CBF5" modified="2020-04-22" version="1">MQVSKTLGIIFLLLAMGCTPNTPRVKKTHLISPTKSLLQAISIVDENTAWVSGHRATFLRTVNGGSDWSAFSYEPIDSLQFRDLHAFNSEEIILMSAGPGKLSRIFRFSLQAGFEETYVMPYEQGFLNTIEFWDDERGLAFGDSFNRELFVLKTADGGRSWTSIDPNQLPPAGEGEGGFAASGTCITSRPGGKAWIGTGAGGNTRVLFTSDYGDSWETYEVPLVKGPSAGITSIRMSDDQTGLIVGGDLGITDQYTDNMALTNDGGQTWQLTTSPVTKGAFYGSDLMSWENASILIASGPNGIDYSTDLGQTYINLDTGNYWAVDLHPSGFGLATGTDGKILKLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K9</accession>
    <name>A0A654E3K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="383" mass="43379" checksum="1159C443E5C121C0" modified="2020-04-22" version="1">MRYRNKLRMKHLHHITIAAVLALGLSCSTPPKQEATTKTYSNPINVEFGDPYILDNGDGTYYMYGTGGGAKDGFATYSSTDLVNWKFEGQVYYGNTDSSWNEKWFWAPEVYKRSDKYYIFFSAQWKENPTNEEENFMIGVAVADSPTGPFVDLYDRPIFNPGYPIIDANVFVDDDGKNYLYYSRACYKHPVESEVADWAREKGWYEEVEESWVYGVELKPDFSGVIGEPVLLLHPPVTMDDQQAEWESRSVTAREINRRWTEGSFTFKKNGTYYIMYSANYYAGKNYAVGYATGAGPLGPFQKAANNPVLQKNVEQGGDVTGTGHNMVLFSPDSSKMYCVYHGRTTASGDNRVLFIDELRIEENGQLVVDGPSTTPNPYPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U2</accession>
    <name>A0A654E3U2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="136"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="267" mass="29943" checksum="CE63C5AA865D9A95" modified="2020-04-22" version="1">MKYLLLLFVFPGMGLPMQEKGVTVFHEQLPDKSIRIFAKNLTEVPQSVKIEGTIKGMESSESLPMVLLVAPGETKYAFLLTPEKGTSYSYNYKYTYIQGDVTAVHNDDYVYQLPFRRGESYLVGQGYNERPTHMDQYAVDFNMDEGTTICAIRDGVVMQAVDNNSKGCPKEECTQYNNFILVRHEDGSIADYSHLKKRGALVTIGQEVKAGQPIGLSGSTGWASGPHLHLEVYVMRFTGQQSVKVEYHLNKGTIGIPRSMESYTQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y2</accession>
    <name>A0A654E3Y2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ORF">MARINOS108_20925</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
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        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="408"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="707"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VXD19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="801" mass="89012" checksum="539D8E071503FC5A" modified="2020-04-22" version="1">MKISYNWLKDYISLSESPEEISSALTQTGLEVEGVEHVEKIPGGFEGLVIGEVIECKPHPDADKLQLTKVDAGTGALLPIVCGAPNVKQGIKVIVATVGTTIYPTSGEPFKIKKAKIRGEVSEGMLCAEDEIGLGTSHAGLLILDTEKPNGTPLIEIFESGSDYVFEIGLTPNRGDATSHLGAARDLKAFFKRPIEPRQSKSLKTEIDRPIEVTVEKNEACPRYSGLTIRGLKIGPSPDWLQWRLKAVGLSPINNVVDITNYVMMSLGQPMHAFDADAITGNKITVKTLPAGTKFTTLDEVERKLSDKDLMICNDQSGMCIAGVFGGTQSGVKDSTTSIFLESAHFSADWVRGTAMRHGLSTDASFRFERGSDPEMTLPALQMAAEMILELAGGHVASEVVDIYPQPILPVRIPTTYQNFHRLIGITLPNDQIIEILNLLDIQTETIDDASFTAIVPPYRSEVTREADLVEEVLRIYGFNNIPLEETLSAGYLSSFSEKEPYKLQEDLSTYLAGKGFSEIQTNSLTNPKYYKDLGLGGEPVEILNKSSEDLGYMKTSLLYTALESVRHNINRKTKNLNLFEFGKIYAQKNEKYKEDQLLAFYMSGDSHEESWLEGARKIGFHDLSRVVFSSLQHLKVVGYTTEPTEDPALEYGLAVKLNNKVIGKLGMLKTKISRYFDIKQEVFYAEFLWKDLVRAAKVETSFEEISKYPEVRRDLSLVLDKKVSYNEIKDLAFKSEKKLLNRINVFSVYEGDKLEAGKKSYALSFFIQDKTKTLTDKGIDKVMNGLISTFENEVGAIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z9</accession>
    <name>A0A654E3Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate glucose phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017473">
        <property type="entry name" value="Undecaprenyl-P_gluc_Ptfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03023">
        <property type="entry name" value="WcaJ_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="270"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="461" mass="53602" checksum="F7092C4CE9989A9C" modified="2020-04-22" version="1">MSEHRFSKYFPVLFLLADLACLNLGIFSANYERFGGLLYTNESYLTLQVVLNLAWLMIFFSTKLHEISREFRLIDHLNKVLTGLVINLSVVFALWFVAKPFYYSRQHLFITYLVFTLLLIFWRSAWHYFIRYYRRKGYNLRNVVIVGYGELATDLERYFRYNPGIGYKFLGYFDNNPEEARGRYLGMVNEVKSYVGKHSVDVIFCCLPRLYDKEIKKLIDFAENNLIKIKIISQFSRLGNKSLSIQKYGDIPVINVGAIPLDSMANQVIKRAFDIIFSSLVMIFIFSWLIPIISLLIKMESPGPVFFKQHRNGRDNHPFLCWKFRTMVVNNEADSKQATKNDPRITKIGAILRKTSIDELPQFINVFLGDMSVVGPRPHPIKLNEQFQPKIDRFIQRHAVKPGITGLAQAKGFRGETSVFSDMSGRVRLDRFYVKNWSLVLDFKIILLTVISIMKGSENAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E432</accession>
    <name>A0A654E432_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="256" mass="29455" checksum="0EFEA1D32FE2F968" modified="2020-04-22" version="1">MKITPIEIRQKNFEKKLRGYDKDEVSAFLLSLSNEWERVLDDNKELKIKLDQAEKEVRKLREVESSLFKTLKTAEDTGANLIDQANKASELHLKETQMNAEAMMSEAKAKAKNLIEKSEMEARQMIEEMQDAIKDLEQNYRALENHRDNIMAELKNFAEDIHDRINRTTKQQAPFKMEDHTKKVKALVRESEAWINKEKLEVKPVKMTPLKQPDLNNTRSHRPAPKPAPAPPAAKKPTESVKSQSGGGSFFDDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E467</accession>
    <name>A0A654E467_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">gpmI</name>
        <name evidence="14" type="ORF">MARINOS108_20384</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="12"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="90"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD18683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="515" mass="56201" checksum="2D443B5C162A2779" modified="2020-04-22" version="1">MACGYYICAMNKKVILIILDGWGIATDKSVSAVDKAKTPFMDSLYGKYVNSTLEASGLAVGLPEGQMGNSEVGHMNIGAGRVVYQDLVKINKAAEEGTLAKEKELVAAFDYAKKEGKKIHFIGLVSDGGVHSHINHLKGLLTAADANGCKDVLVHAFTDGRDCDPKSGKGFMQEVQEHMTKTTGKIASITGRYFAMDRDKRWERVKLAYDAMVNAKGEVETEDVLSAIQASYDAGVTDEFIKPIIHTENGAPVGHIADGDVVMCFNFRTDRGREITEVLTQNDLPDHGMKTLDLYYLTMTNYDDTFKGVKVVFDKDNLKQTLGEVLEAHGKKQIRIAETEKYPHVTFFFSGGREKEFVGETRLLCPSPKVATYDLQPEMSANDIKDKIIVELKKEEVDFVCLNFANPDMVGHTGVFEAAVKACETVDACASEVVDVALAHGYSSIIIADHGNSDMMINPDGSPNTAHTTNLVPFILVDNDFKGTLKPGKLGDLAPTILKLMGVPKPAEMTGEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E486</accession>
    <name>A0A654E486_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ORF">MARINOS108_20893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="229"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="408" mass="46996" checksum="3B6597845410F02B" modified="2020-04-22" version="1">MILSSLLILVNFELPDNNICSEAQYQGIFMIETKKEQEYGVLVAVTPKFQADDKTIEFLEELEFLVQTLDIKVEKTYAQKLERPDTKTFVGKGKLEEIKEFVKAKNIGNVIFDDDLTPSQLRNLEKELKVKIYDRSLLILDIFLKRAQTTQAKTQVELARYQYLLPRLTRMWTHLERQRGGTGTRGGAGEKEIETDRRNIRNQINVLRKKLDKIETQAATRRKSRDGIVRVALVGYTNAGKSSLMNLISKEQVYAKDELFATVDSTVRKVVINQIPFLLSDTVGFIRKLPHNLIESFKSTLEEVKEADFLLHVIDVSNPAYEDHIQVVEKTLEEIGAADIKTIRIYNKVDKVEDIAELHLNENGANDQAMFVSAKTKYHLTEMRELLAKEVKKEHIKIYPNYLEPETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A1</accession>
    <name>A0A654E4A1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotase</fullName>
            <ecNumber evidence="7">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="52"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="50024" checksum="4F7A62AEE4199679" modified="2020-04-22" version="1">MASKYLIKNAQIVNEGSIHSADLLIEGQRIVKIGADLKVDGAVREINAEGKYLLPGLIDDQVHFREPGLTHKAEIYTEAKAAVAGGVTSFMEMPNVIPQTTTQELLTAKYEIGRQKSLANYSFFMGATNDNLDEVLKTNPAEVCGIKVFMGSSTGNMLVDDEKTLEELYKNAPMLIATHCEDEATIRQNMEHYVAQYGDQIPFELHPVIRSAEACYKSSSMAVALAKKHNTRLHILHISTGIETALFDNTLPLKDKRITAEACIHHLWFSDQDYKNKAQWIKWNPAVKSESDRDKIWEALLDDRIDIIATDHAPHTIAEKNNPYTKAPSGGPLVQHSLTALLDFYHQGKISLEKIVEKACHAPAECFQVAERGYIREGYFADLVLVDLHKPWKVSPENILSKCGWSPFDGHTFQSSVEQVWVSGHLAYAEGKFDESKKGARLTFERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F2</accession>
    <name>A0A654E4F2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="26226" checksum="1C4325DA0014F723" modified="2020-04-22" version="1">MKQFLITLLAIGILSGCDKEESAPNTQLEIAVLDAEGNGASNSEVNVYLSLASFLDQESPIANGLTDATGAITFYGLKPKQTYYIDVRRVNATNWISQITSPYIEEGMNTFSTVISENWYSNLSNAAGISWSPKYVFIDDVWYIYNDCFNDDQYLFKKNLKMSYRNHTKCSASDPDFYTGEWFGTANQVTIYSDLEGDTGLSFKLVESDPAYFLGELRINGGELLLVRFEKMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M2</accession>
    <name>A0A654E4M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="33827" checksum="869B9D71FB9D648D" modified="2020-04-22" version="1">MLPPAPIYPPFIKKYIRYRKWIPKNHQNQYFPNIIADMRNTSCIKFGIISILLLLTNLPSTAQYSIDGLDLNQNIYAWHDKALGVDKTGILLGEYQEIQRQSRETSQFFDDSQWIANRLKYRGEIYEGIYLSYDIESDLLLIRHPTNYNYHSQAIKLIQQDVEWFEYSGHTFRYIHEPVLHFGEGFFDEMYMGEHLQLFAKRIKITETDRVISYVTADKFIIQYLGEYYRLRSKLTVMKLLKPYKKEIRQFIKTNEIKAKPEYESDMIQLISFCNQLLNAPTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S1</accession>
    <name>A0A654E4S1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">rpsC</name>
        <name evidence="13" type="ORF">MARINOS108_120492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="27694" checksum="F93D8D10CD76F857" modified="2020-04-22" version="1">MGQKVNPVGFRLGIVKGWDSAWFGGKDFSDKIVEDHKIREYISARIPKGGISKVIIERTLKRITLTVHTARPGVVIGKGGSEVDKIKEELKKLTGKDLQINIFEIKRPELDAKLVGESIAQQLQARISYRRAMKQAIASAMRVGAQGIKVKVSGRLGGAEMARSEQYKEGRIPLHTLRADIDYAISEAATVYGKIGIKVWIFKGEVFGKRDLSPNVGQASTGGGNSNAPGQPGGPRRRRGGANEGPKRRRDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S7</accession>
    <name>A0A654E4S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S41A family C-terminal processing peptidase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_60161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024787278" evidence="4">
        <location>
            <begin position="23"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="551" mass="61487" checksum="5A9605B05F7EC2FD" modified="2020-04-22" version="1">MNKKWKAIVAICAISIGFLAFKATPVGDRTFEIVKNLDIFATLFKEVNAYYVDDIHPDQLMRTGITAMLASLDPYTNYIPEDDIEDYRTITTGEYGGIGAIVDKKGGVSTVVMPYEGYPAHKAGLKAGDQILKINGIVLEGKSSDAISKLLKGQSNSDIVLTVKRFGQEKLFDVTLARERITISNVPYFGMVAEGIGYVKLTDFTTEAGAEVRNAVNELKADGAKKIILDLRGNPGGLLEEAVNVSNVFVGKGREVVTTRGKLKNWTKTYNTLNDPADTQIPLAVLISNGSASASEIVAGVMQDYDRGVLVGQRSYGKGLVQQTRPLAYNSQLKVTTGKYYIPSGRCIQAIDYSHRNPDGSIGKIPDSLKSEFKTQSGRSVFDGGGVNPDIEVEPFEYAPIAYSLMSNDLVFDYATRYYYAHPEIKPAKDFTLTDAEYDEFKNWLKDKELNYTTQVEQNIEKLIASAKQEKYYQDIEQQIMDLKRETLHNKDQDLITFKPEIKKLLEQEIAGRYYFQSGMIESTFDQDREVMEAIKVLNDSERYQSILKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A2</accession>
    <name>A0A654E5A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="400" mass="43420" checksum="183CE2A01C0C10B6" modified="2020-04-22" version="1">MSTKFYNLSKSTPYRPQDMKTSQSIKGITSILLAIFGFFVSIHLLGLSFQVIGNGFSEFFDMAFANPAIGLFIGLLGTAILQSSSTTTSMAVAAVAAGSVSLENAIPVVMGANIGTTLTSTIVSMSYMTKTAEFRKAVSAGTVHDIFNVLTCVLLFPLELRYGLLSRLSTGIASMVHTPTAVDTLPSKLSIYHWLDIGGNLLINWFGPFVLLIASVVLLFYIVKKISNILYDKLIGNAQSKFESIAFQNTFKSFGWGFLLTSVIQSSSLTTSLIVPLAATGKVKLKRAFQFIMGANLGTTITALLAALFKSEAAISLAIAHFLFNSIGVLIFLTIPLFSRIPLYLSDKLGAISLKYKVTAFAYILVVFFLLPFTLIYFSKSRNMAAYEHKVPSIELTSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A3</accession>
    <name>A0A654E5A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NDP-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="339" mass="38586" checksum="9E0CECCD70537377" modified="2020-04-22" version="1">MKETIVILGASGTLGTYLVDELSKMGQYRLVVCGNRNLNEAYYQRLGIETAKIDIRQKAAFEALPTSNVKAVVQIAGVMPSRMEGYEPSLYLETNILGSFNVLEYCRVHNVEKYIFTQSHSDVAGFWNTGKAIPPDASRRLNLKGDHAVYIISKNAAVDLSEHYFQDFGIKNVILRLPTIYSYRSFSEMYVDGRRAIMAYRFLIDEAKKGSPLEIWGDPTISKDIVYVKDFTQMVVKAISSENSRGFYNVATGKATSLEEQVRGVAKVFNPTGRSSEIIYRPEKPSQTSYLYDIENAKKDLGYEPKYNYLQLLEDMKLEMELGRFEHIDEARLNYKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5L3</accession>
    <name>A0A654E5L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="2" type="ORF">MARINOS108_60012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22319" checksum="37EA0CA8113FC44D" modified="2020-04-22" version="1">MSGNRPALVGITGGIGAGKSTVARIFKTLGIPVYDADSRAKWLMNNDRELKEGIVSLFGTEAYDHQQINRTHIARLAFSDQSLLSSLNALVHPAVAKDFDHWAGKQATPYVLKEAALLFESGSYQSLSAIITVTADESLRMRRVLKRDAHRTEQDVKKMMAAQWAEDKKVARSQYIITNDETTAVIPQVLKIHEQLLGKISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5L5</accession>
    <name>A0A654E5L5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032286">
        <property type="entry name" value="DUF4837"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16125">
        <property type="entry name" value="DUF4837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024894899" evidence="1">
        <location>
            <begin position="22"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="358" mass="41666" checksum="B9DDB4FB896D672A" modified="2020-04-22" version="1">MRTLFLFFLASILIFTSCKSATDKVKEDFMPLARGEADEIILVIDSAQWESELGNTLRDMYQQYMRVLNQDEYEFSLNKVNPRKLNSVLKHARNMIFVMTLDSRTLESKTIRENFTDNSLKMIQQDSSLFYTVRKDEFAKGQIVLYLFGQSEEQLVEQLKDNKSSLVALFESAVRERTREKTLKKTKPEMMAAITENHGYSIQVPFGWDLAKDVKDFIWLRRLEADSELNVFVYEGDYKDRKVFEHVDELRDEITGTYLRDSEKPDLYIQRQDIIPVYTERVTFNGKFAVEARGLWKINNNSAGGPFVSYTFVDEKTQKLYYIEGYVYAPGTKKKPLVREVDAILSTFRTSSEVGDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5S3</accession>
    <name>A0A654E5S3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_60127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="21467" checksum="C92A687CAA6385EE" modified="2020-04-22" version="1">MKIYFATHNTNKLRELRALIPENLELLGLDDLGLQEEIPETADTIEGNSAMKTRYVFEKHGVACFGDDTGLEVEALGGAPGVYSARYAGPDNDSQANMDLLLSNLKNEENRKARFKTVITYIDNQGHEYQFTGIAKGEIIREKTGAQGFGYDPVFLPEGEDRTFAEMSAAEKNARSHRARAFEQLIQFLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E620</accession>
    <name>A0A654E620_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="106" mass="12438" checksum="3E2067E988881F5A" modified="2020-04-22" version="1">MVFTEIDKKTMQILCTLAKLAGPAGEKRDAIVNIGQFLGVPKDDTLELLEEWEEYDIMHLASEEEKRHFVNYCFSYMNKDYHPKKSEREFYQQVVNNLGLTARFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E678</accession>
    <name>A0A654E678_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacillithiol biosynthesis deacetylase BshB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bshB</name>
        <name evidence="1" type="ORF">MARINOS108_90060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023842">
        <property type="entry name" value="Bacillithiol_biosynth_BshB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04001">
        <property type="entry name" value="thiol_BshB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27087" checksum="18D25B4FFDCB6210" modified="2020-04-22" version="1">MKINILAFAAHPDDVELCCAGTLIVHQMRGFTTGIIDLTQGEMGTRGTAEQRLQEAKRAGEIMKVSVRENLGFADSFFTNDTEHQLKIVQKIREFQPDIVLTNALYDRHPDHGRAATMVEEACFKAGLKKVETLDAEGNPQKAWRPKKTYFCVQSVSLTPDFLVDISDAQELKMEAVRAYKSQFFDPNSQEPQTYISKPEFMQMIEARALEYGHRIGVKYAEGFMTKQSLGVKDLYHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6V4</accession>
    <name>A0A654E6V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_RiboL-PSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041519">
        <property type="entry name" value="HEPN_RiboL-PSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18735">
        <property type="entry name" value="HEPN_RiboL-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_RiboL-PSP" evidence="1">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18623" checksum="F48F76DBCBF2B236" modified="2020-04-22" version="1">MFNNAELNKQYNRIEKLIKKTKQFEPDDELRSHLTKYICVLCSGFIENSVYHAFCDIADRSCAPSVVLTYSKAQLYKIQNANAEKIRDLTKSFNPDWHDGIRDFLQKDNRGSAINYILKDRHNIAHGRDSEITIGKLEDYLKKTVEVIIYLETQMDRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7G8</accession>
    <name>A0A654E7G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="256" mass="29302" checksum="36BEC9F8E293D5D8" modified="2020-04-22" version="1">MSVYTTEITSDQIPSDNPIHQRLLKAYYAAEPLVSGDLLELGCGEGRGVSLLLNKVDSYLGLDKIEGVIETLRGKFKNARFESGVFPPIDLPDNSFDTVVSFQVIEHIQQDELFLSEIHRILKPGGKAILSTPNIKMTLSRNPWHIREYTADQLATLAGKYFSSVDMKGIAGNEKVMEYHERNRKSVQKIMKYDILDLQYRLPAALLRKPYEILNRRNRNKLKNQSDELVLSISHEDYFVREKSEQNLDLFVILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7R4</accession>
    <name>A0A654E7R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5172" checksum="379C134199281B26" modified="2020-04-22" version="1">MNREDSQTSKLAQVTDEVINVLHPKIIHSRDHKNFRGKTGQGSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7T7</accession>
    <name>A0A654E7T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mono/diheme cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="619"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="742" mass="83750" checksum="C251D3D1759F56C6" modified="2020-04-22" version="1">MSVKSTMLTLLVGLLFIKCTERKYSETIYQKPEIVKEAPSTFLSPEESMETFYLPEGYRVELVASEPMIDEPVAIAWDGSGRMYVAEMNTYMQDVDGTGTNRSISKIRLLEDLDGDGKMDKSTIFIDSLLLPRMILPLENELIVNETYSYDLWSYKDTDNDGVADKKERVYYNPNPRGGNLEHQQSGLVWNLDNWVYTTYNPMRFKFKKGKVIVDSLDNMPSGQWGLTQDEMGIMYYSAAGSENPAYGFQQAAVYGDYNPKGRLSEGFVEPWPIVGTPDVQGGPKRLREDGTLNHFTGVAGQEIFLGHRLPPSTYGDLFIPEPVGRLIRRAKVRVEDGKKVLYNAYDQAEFMASTDLNFRPVQAKTGPDGALYIVDMYRGIIQESNWTRKGSKIRPHILRKDLDKNIGRGRIYRIVHEQIEPDGRPDLAGKSASELIEFLGHPNGWYRMTAQKLIVLKDDQTVVPVLKSLALDNTSFFDRIFNGDKDFGIERVHALWTLEGLGVVDKTLLLQKLKDEDPRVRITAIRLGETFLRSGGSDFIPHLKPLVADTSIEVVNQLALSLRYSRSEAATDLLSEIDSKYQQNEIVAHSVMESLKKDDSRLEQLKLRIAKRSLGDKRSILGGYDTYKQLCITCHGPDLKGVTPENGLAIAPPLLGSPRVTGDPDKLSKILLNGLIGPIDGQEYGIMTSYKSNDDQWITDVLNYIRAMNDADAFNKKVVRNARIETEDREDFWTLEELATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8K9</accession>
    <name>A0A654E8K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014553">
        <property type="entry name" value="Aminopept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10023">
        <property type="entry name" value="Aminopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="339" mass="38788" checksum="7C15953F4B03B6CF" modified="2020-04-22" version="1">MLKKISWGILLILIALCLYYWNWLSYGYNQAKGQLKVITQSRPIEDFLQDPNFPDSLKQKLELTMAVRGFAVDSLGLNKSDNYTELYDQKGKTLLWNVSASEPYALKAYTWQYPFLGEMPYKGFFDLEKAKKEADLLKEKGLDVRIRTVGGWSTLGILKDPLLSNMLERNDGALAEVIIHELTHATLFVKNEVEFNENLASFIGEKGAERFLVSHFGDSSAQHLEYLQSLADSKTLTRIILAGAGRLDSLYGSFTDSLKTSLKDSLKNNCIQHIANDLKNGAFYNTRYQNIFDDVLPNNAYFMAHRRYHNQEDSIQAIFHQYDDDIKLMLTAMKIKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9G6</accession>
    <name>A0A654E9G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024924022" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="24261" checksum="CEB41EB607ACC190" modified="2020-04-22" version="1">MTSTRPLFLVLLMSLIVWTSCESEDAADVNQQRIETNYTLAYNAGDRKTTASASFLFGSTFLKINSPSSITFDDDRLKETEILGIVDYQKSYGTKVPSGTFVYTNNDGVVYRNTLSLPADIDLPSSLTELSIAEGARITWEGAPLKSGETVTFHLSGDGGDFYASIGLVNATFIEIDSADIQATLLGQCGMSISRSFSGSLAEATEEGGVAHSQITSETYAVNVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB74</accession>
    <name>A0A654EB74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_140138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="207"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="383" mass="40589" checksum="2A146CB1F620A288" modified="2020-04-22" version="1">MSSHLRFFFATRESLHLGLIFTCNSLLFGNWITRIPDMKDTIGLTDGELGLALLGAPIGAMCIMPISGWVIARFDLGRTLVISGLAHVISLPLLALSDSFWGLAIALFFFGFSNAIMDISMNATAAVIERKHKRAIMSTCHGMWSLGGMAGAAVGSIVAGLGTSTLPHLGLVGGIVFVMILLLSDTLYHMKESRNAGDKVFAWPRGPLLMLAFMAFCILLSEGAIADWSAVYMRDVVLADAYLVGMAYAGFSMLMAIGRLTGDSIIPGLGKKSVVFYGSLLSVIGLCVAIFFESQDLVIVGFSITGLGYSCIVPVLFISGANQPGYTAGTGIAAVTTLGYAGFLVGPPLIGLLAEAYSLTVGMSFVLFCTLMVTLLSLTIKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBT3</accession>
    <name>A0A654EBT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor SusC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">susC</name>
        <name evidence="8" type="ORF">MARINOS108_20167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024812056" evidence="5">
        <location>
            <begin position="21"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="113"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="387"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="997" mass="108990" checksum="B093292392BA1773" modified="2020-04-22" version="1">MKKYTLLIIVTLVSCATLWAQQSVSGQVKDADEGFGLPGVTVLEKGTNNGTITDVDGYYTITVAEGAVLTFSFVGYQTPEVAVGNRTNISVNMETDLTELSEIVVIGYGQVQKSDLTGAVASVQAKDFNKGVLTSPQDLLVGRIAGVQVTTNSGAPGSAATIRIRGGSSLSASNDPLIVIDGFPVDNTTISGLSNPLSTINPSDIESFTVLKDASATAIYGARASNGVIIVTTKKGQSGKPKFSVSSRTSVSTPIAYVDVLDGDEYRTLVNDLHEEGFSGINDAALNRLGTENTNWQKEIYQTAISQDVNVNASGAIKDIPFRVSYGYTDQEGILKTTYMKRHSISVNTNPSFFNDQLKVNLNVKETLANTGFGDQGAVGAAVNFDPTQSVYADNTKYGGYFAWTTENLPDGTMDPDGPANTFSSNPVALLKLRNNVADVNRLIGNIQFDYTLPFLPGLSANLNLGMDRSNTDGIDDALPGSTWTYRDYTGENGRLLDYDATNSSELLDFYLKYKKDFTDHQLELTGGYSYQHFQREGSTFNRNGDQTQVVEDSRYINENFLISFFGRLNYIFKNKYLLTATLRNDGSSRFTGENRWGLFPALAAGWKISEEGFMSAVPVVSNLKLRLGYGVTGQQDVTSNQYPALPIYRESIGGASYQFGDTFVNTLRPDPYDANIKWEETTTYNVGVDYGFFDDRVYGSVELYKRETRDLINNIPIAAGSNFSNFLITNVGNLENEGVEVTLNVRPVLKPDFTWNIGVNFTHNTNQITKLTKTDDPDYQGVAVGAISGGVGNMIQIHTVGYPANSFYVFQQVYGTDGQPLEGLYVNRTGETGAVTSNELNKYHYYSPAPEVLMGFNSRVAYKQFDFSFSSRLSLNNYVYNNLQSGGVLSGLYTTSGGGYFNNITASAANRGFTNPQYWSDTFVENASFFKMDNISLGYSLDKLFTDAIKLHVSLTVQNAFIITNYDGLDPEVSGGIDSNIYPRPRTFLLGLNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECR5</accession>
    <name>A0A654ECR5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024916547" description="DUF4190 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="23894" checksum="B12EB48FD376FE61" modified="2020-04-22" version="1">MKTNTASLLVLMAVLFTACSPTKQAMECPQFYKKKDRIKSQHLTLRSFKKTSKVAKTPQKIQPNQELIDAPGNHYPETVSLYGLTTSPADLITYRYKPYEYKPHEESKEESAETTFIGDDFPPQKVISKDELQSVKKEVKRVKETKGSNPHGMAIASLVLGIVSLFVAGIPLGILAVIFGSISMRRLEKGNGRGMAVAGLILGLVGILGALIILTTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF07</accession>
    <name>A0A654EF07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP nucleosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010944">
        <property type="entry name" value="AMN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011271">
        <property type="entry name" value="AMP_nucleosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF6">
        <property type="entry name" value="PTHR43691:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01721">
        <property type="entry name" value="AMN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="256" mass="28408" checksum="65AE0E27BF0A8873" modified="2020-04-22" version="1">MKTKQEIIENWLPRYTGLPLENFGQYILLTNFKNYVTLFAEWNDVEVVGTGHPMQCATADGITIINFGMGSANAATISDLLGAIEPKAVLFLGKCGGLKMKNEVGDLILPIAAIRGEGTSNDYMLPEVPALPAFALQKAISTTIREYGQDYWTGTVYTTNRRVWEHDNKFKKYLKKIRAMAIDMETATIFTTAFANEMPAGALLLVSDIPMIPEGVKTDESDKKVSAQFVEQHLKIGIDSLKQLINNAQTVKHLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF17</accession>
    <name>A0A654EF17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025455">
        <property type="entry name" value="DUF4276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14103">
        <property type="entry name" value="DUF4276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="26182" checksum="DEDDABB2A0DCAD81" modified="2020-04-22" version="1">MKRLIIIGEGQTEQAFCEEILRPHFYSHDIQIESPTISKTGGGIVAWHHLKDDIMRYLSRPDVYVTLLIDYYGIQDKHAFPEWENAKQIPPRPGLANRMDHLEQGMATDIPDAVRYRFIPYIQLHEFEALLFANKEVFDRSFTANEFEDYDYLNETITAFPNPEDINDGTETAPSKRLERILTNYTSHKPSTKALWGPLLADAIGLKVIRNKCPRFNAWIETLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSL2</accession>
    <name>A0A654DSL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="4768" checksum="346D00B0F8E75C21" modified="2020-04-22" version="1">MLLTLADKGQSANSGYSPVSCGLNIAVDFITFLATTPKVHENTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTE6</accession>
    <name>A0A654DTE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="30436" checksum="3B19F623D069D533" modified="2020-04-22" version="1">MKKLLFILLLLPVTVFGQRYKEQINFNAAGDQQVALGKFIIGAAIRVECQISGGWAEDGGIYHIAADWGNQPKVVYRGESSISTRLKFHGYVDPSSNSFVYLFASWDNQSPSESSANNLKLTIYSEGFFDTNAIGTFSNAQELENVLIVQSNTGNVGIGTTSPDSKLSVNGTVHTKEVKVDLIGWSDFVFEKEYELLTLEEVEQHINENGHLPEIPSEAEVTENGINLGEMDAKLLQKIEELTLYMIDINKQVQQLTLENQELKEKVQSLENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTF4</accession>
    <name>A0A654DTF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="327"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="811" mass="90619" checksum="B0A463498C5EEE39" modified="2020-04-22" version="1">MWRNYLIVSWRNIKKHKAFTAINVVGLSLSMSVCLLLILLVYDHYSYDTVHPHGDRTYRVLTYQKGARGIFSNGYATSPLPIGETLSSGYTIADTYTNLNHGLHGEIRSAHKVINPESEFDGRSLFADHNFFKVFGFDLKEGDPLTALNEPYSMVLTTQMANLLFPQKSALGEEVIMEGMGRYKVTGILTEELPKSHIKFKLLASFSTIPLLVKENHMTNEYKEWETIWMNYNYIVLNEKTSKAEAQALINQITSEKMEIKEDHPGYEFELQAISEIVPGRLLSNEISFTLPKIVLLFFGLLGLVVIITASINYANLSIAKSLTRTREIGIRKANGASKAQIIIQFLVESVLISTLSLVVAIGIYWFLIDQFNALWIFNQVGITLEDTVFAYGFFLLFSLLLGIISGVGPSYFVSRLDTIRSLKGSGAFSNTIKSGFISKISGKKILLSVQFGLSIVMLVSIFLIRDQANFLTRSSFGFDDEHIYFVRLQGHDPKVIETEFANTPGIENVTFTSHHPAVGRSHGANMKLNEADEFITIYHFSVEERYVSVMGLELIAGTDFPRAANQEQEKFIVVNELATKRLGFESPAAAVGELVYIENDTRVKIVGVVRDYHWEPLMKSIEPLALRIKPGDYQFAYFKIGVNDPGAFGKGMEQKWNQYDQSRTFQGGFLNEETDLFYQFFYDLGGILTFISLIAIAITALGFLGMVSFHLKTRTKEIGIRKVLGASFGQITLAMTGGFMVMLASTALVMVPVAVFANGLWINQMAVHSPISIFNLGPAILIVVLLSGATILAQVWRNTSENPVNALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTK6</accession>
    <name>A0A654DTK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021352">
        <property type="entry name" value="DUF2971"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11185">
        <property type="entry name" value="DUF2971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="33223" checksum="EB9825CCF8E840B8" modified="2020-04-22" version="1">MTYFTKEESIEFEGEKTLYHYTSIYTAIEKIFPSNNLRLSPVTSASDPMERLSPNPSVSCYGYDEDHKRLNEKIDGKKIAKKINAFYGSLRQLCLCRNSPIDFEGQFGGVFEPIDHFGFAKPRMWDQYGDRFKGVCIALSRLKLEEQLPSNYRLLNIGYSKNHLFRPNIDTSSVDLNQIEKMGEQEYINWKIESEIKKIGVKHSDYRDEDECKIIATTDNDYEYINITRCIQGIFFTNGLNYTYESYLKETADRYQIPLFQIDIRRTGLNVNVFYNKRPQEGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTU7</accession>
    <name>A0A654DTU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="4939" checksum="6D0F7E34A140C28C" modified="2020-04-22" version="1">MPLLMNLENQAVTTSIESVASILIIQLPNVIGSLTTASKQKVRAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTV5</accession>
    <name>A0A654DTV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron transporter FeoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="3">
        <location>
            <begin position="140"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB_C" evidence="2">
        <location>
            <begin position="252"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="3">
        <location>
            <begin position="310"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="475" mass="53020" checksum="6B919DCDB7C732D6" modified="2020-04-22" version="1">MEKLKNETDEILTFASSLRWKMGEDYHDKLTEGIYSDAAAITKRVEIKKNEKESYHFDRMLDKVLTSRTFGFPIMALILSVILWITIQGANYPSSMLNTLLLEMVYPFLKGLSAQLGVVWWLDGFILDGVYMAVAWVIAVMLPPMAIFFPLFTLLEDFGYLPRVAFNLDGLFKKSGAHGKQALTMSMGWGCNAAGVVATRIIDSPRERLIAIITNNFSLCNGRWPTQILIATIFIGALVPAGWSGLISSAAVIGIAFLGIFFTFFTSWFLSRTMLKGEVSTFTLELPPYRPPRFWKTIYTSLIDRTIIVLWRAIVFAAPAGAVIWLISNISISEITLAAYAIDFLDEFGFLIGLNGVILLAYVVAIPANEIVIPTILMLTVSHFGIVDMGAGDGVMFELDSTTETANILKTGGWTLLTGINLMLFSLLHNPCSTTIYTIYRETKSWKWTSVATFLPIVFGLIVCFLVAQFWRILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTZ6</accession>
    <name>A0A654DTZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein OmpA-like peptidoglycan-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024883460" evidence="3">
        <location>
            <begin position="19"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="584"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="698" mass="78233" checksum="DEAB86803F6AA559" modified="2020-04-22" version="1">MKKLLFALLYLMFFTAIAQKTVFRDDFRDNRNQWTVATKTEYVSYLQDGKYVISKKTESGGWLFFKELYTEYERDFVIEAEAKQVSGVDNNGYGLLFATADANNANFFIVTSNGHFRVAGYDGGSYKAVTEWTKTDKVSKMNEINSLKVERKGSALTFYVNGYQVYSMPAAEMDIRGPKSGFVLYDEMKVEFDFIEIRQDYRNINLVPGTDTLQIVKEPLGTEVNSPYTEKSPVISADGLTLYFSRDDHPGNNTRRDRSDVWYSKMVDGKWQMAQNMGTPINNAGHNFVISTTADNNGLLIGNTYHADGSSNTSGFSYTNLTPSGWEVPRDVTVENYYNDNDYTESCLSSSRKVMLSTVERKDSRGSKDIYVSFLQEDSTWSEHVNLGDVINTPASEASPFLAADDITLYFSTKGHPGFGSNDIFMTRRLDDTWLNWSEPQNMGPQINTPNWDAYYTIPANGAFAYVVSESYYEGDLDIYRIKIPEAAKPKAVTLVYGKVLNAKTNEPLAAEIQYGDLGTNKEIGRATSLAADGSYKIVLTSGKSYSFLASKQNFVTVSDNINIEQSEEYQEIERNLYLAPIEVGQTVLINNIFFDFGKATLRETSFPDLDRLVTLLEKYEGMKIEISGHTDNVGSDAANQALSQSRAQAVLDYLSGKSIAGGRLISKGYGEAKPLATNDTEEGRQRNRRVEFTITAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU12</accession>
    <name>A0A654DU12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase family 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024842307" evidence="5">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="67"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="548" mass="61280" checksum="E588CE88B13C058F" modified="2020-04-22" version="1">MKYSLAFLSLILIASAYAQDTPVLSISGVEVQHNQIEKVSGSSRLNHTVDLKDFEVSDVLSAPNPSPEAVALYRYIQDMFGKKTLSGQMWAPWGINEIDYVQNATGLKPAIAGFDYINEPSNALENQRAINYWNDGGISTMMWHWGAPGVGEGYENSKATIDIDQCFIEGTPEYEDFWGDLKRIGDWLQKLEDANVPVLWRPLHELNGNWFWWSKGGSSQFKRIWITMYDYLVHERELNNLIWVLCYTGDPNGAWFPGDEYVDIAGADTYDNTTDAHLTMFNDVLESVGGNNYPVTFHETGNPPDPEDCIRTGAMWSWWMIWHTDWLTGVDENYLRNTYQSHLVITLDELPDIKNDYGWDAECAPSKITASIRPGESADWYETNKIGVDDGSGSITFRVDTDDTGTWKWSGYGTAGAADGSDTERTVPLNGLGTATATFTNECGAITTQTFHVVDDVLIRGVLATRPETGTVSVFPSPTSDILKIRFRNPDSISGARTTVYNQEGRLMLEQRSKGEGTTLNISSLPRGIYLVVVEQQESRSVVKIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU97</accession>
    <name>A0A654DU97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="16895" checksum="B137A9879390E9D7" modified="2020-04-22" version="1">MKYFLKPSVIGILFVALFFGNCSEPKKKQETTKPVVKTEPEPAGLTDEQKTFIKERFQQYAEVKAKFDKTKKSDGVQIGELNRSLRELGEFPSWFSKNTPEIRYLKLVKSFVTDMGNALATRNDQLLEIARNDYDKYSKDLQNMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUI5</accession>
    <name>A0A654DUI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized damage-inducible protein DinB (Forms a four-helix bundle)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302">
        <property type="entry name" value="PTHR37302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="17130" checksum="60F46BA0A6CF23FC" modified="2020-04-22" version="1">MKAFFKDIFEYHHHFNQQLVDLLIREQERISARTTPLFSHVINAHQIWNARVVPEKPLGVHELHSLETCKAYDQSNHLRTLQIIADADLSKAISYRNSSGSEFENTIQEILFHVSNHTTHHRGQIISDLRQQGIEPIVTDYIFYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ3</accession>
    <name>A0A654DUJ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="21876" checksum="CB4BC9DAB4969A99" modified="2020-04-22" version="1">MKTPSEDLIQDLIERTRQTLNATENLKQEPIDLLNWKPAPERWSVLECIEHLNLYGDFYLPEIARRIRESQKPAEPYFSAGLLGDYFAKSMLPKEKLNKMKTFDDKNPNGSDLSMDTIDRFIAQQKELLVLLNKSRSVSLNKTKTSISISKLITLRLGDTFRVVIYHNQRHLVQASKVLSLQASPEMSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP4</accession>
    <name>A0A654DUP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="112" mass="13132" checksum="EE6B0993CBF64AFA" modified="2020-04-22" version="1">MPYKEKEIEKKYFTIGEVADELGVATSLIRFWEGEFDIIKPKKNRKGNRQFTKEDIKNVKLIYYLVKEKGFTLQGARDFIKNDVEAATNKVELIESLKKVRSFLVTLKQQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX3</accession>
    <name>A0A654DUX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rifampin ADP-ribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038611">
        <property type="entry name" value="Arr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021975">
        <property type="entry name" value="Rifampin_Arr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12120">
        <property type="entry name" value="Arr-ms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Arr-ms" evidence="1">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="27655" checksum="4936F420248521C5" modified="2020-04-22" version="1">MEFNPNNHIVKRCLQGMAMEENDQPTAANRLFLQAWNEATNDFEKFMAAHYVARHQHKVSDRLKWLETTLTYALKVNDDTVASAFPALYTNIGLCYEELGDADKAQEHHALGASFQAKPSDKGPFYHGTKADLQVGDLLVAGNLSNYKTDLKMNHIYFTALANNAGLAAALANGEGRERVYIVEPSGVFENDPNVTDKKFPGNPTRSYRTEAPLKIVGEVADWGRQTPEEIQKWREKLANNKGEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV79</accession>
    <name>A0A654DV79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MARINOS108_10916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
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        <property type="protein sequence ID" value="VXD12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:respirasome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:copper ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:cytochrome-c oxidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="153"/>
        </location>
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        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="12">
        <location>
            <begin position="162"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="361" mass="40805" checksum="B33F6DA4E06DE44B" modified="2020-04-22" version="1">MLDLIIILAVILVVGILISIFRVFTLVGIVKGDSKKEIPASNKLQASLLVVFLVLGIVGFFYYSFGGLDESFVLPLASEHGVVTDRLFWITMAITGFVFIVTQIFLFGFSYKYQHKEGNQAHFYPHNSKLEYIWTAVPAVVLAILIISGWKAWVDITGPAPEGAEVIEVMGYQYSWAVRYGGADKKLGDYDYKKIDVVNQVGIDFSDRASFDDFIPTKLYLPKGKPVLLQIRARDVIHSVYQPHFRLQMNAVPGMPTRFWFVPTKTTEEMRTETGNPEFNYELVCNKICGKGHFAMKYLIEVLEPEEYEKWYASQDAWLKQNADYLSQVPDELQEMARIASGIEDNAGIQKVGNSVVSSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV82</accession>
    <name>A0A654DV82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5621" checksum="066C699AF027C9C3" modified="2020-04-22" version="1">MRSLSNCLASGIYLSQRIFFGIAFEGWRTFVTFSTFKLSVDKPPLSWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI1</accession>
    <name>A0A654DVI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
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    </dbReference>
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        <property type="entry name" value="DUF779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05610">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009151">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="14964" checksum="6AFB04654533A498" modified="2020-04-22" version="1">MSHLISLINRGDNMTQRISVTDDAIKIIDQLKERYGPLMFHQSGGCCDGSSPMCFENGDFKVGESDIQLGMIADCPFYMSRDQYDYWKHTHLTVDVTPGRGSSFSLEIPLGVRFIIRSRLLSDEEFHLFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI5</accession>
    <name>A0A654DVI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP</name>
        <name evidence="8" type="ORF">MARINOS108_11071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="8"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="429" mass="46006" checksum="90ADA1A2B4AE46EB" modified="2020-04-22" version="1">MSILDLITLLIFLAAVFTLINITVLKLPSTIGLMAIALMMSVAILLAGYIFPSVTRGAEHIITEFDFKEVLLGVMLNFLLFAGALSVDLKKLLEERVAVLVLATVGTLLSTFIVGTLVYYIFPVLGVEIDYIFCLLFGALISPTDPIAVLALIKKFGMSKNLEIKIAGESLFNDGVGVVIFLTILGIAQSTYGGAEAAHGAHGAGEITASSVAILFGQEVVGGVLMGAIFGFLGFRLLNFIDNDHVELEVLVTLTLVMVGGRLAELIHVSGPLAMVVMGLFIGNEGRDEKLANATGEYVFKFWHLLDEALNAILFILVGLEMIVIANTFSPTSFLVGGAGILIVLTARFIGVSLPIKAMSIFRTFEPKTIIILTWGGLRGGISVALALSLAEFTWMEPVIKETILFTTYCCVVFSILVQGLTMGFLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ0</accession>
    <name>A0A654DVJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipoprotein-releasing system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="299"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="45509" checksum="49EE3AFD161462C6" modified="2020-04-22" version="1">MSLPYFISRRISKNKTGSFSTVINKIAVVSIAVALAALICTFMILKGFEDTIKQKIYSFSGHLIISKYTLSTSFENSSIVVEDSLMNGLRALPGVDYLQTYAYKAGLLKTNDEVQGVILKGLDQSFDTTAFAMHMVDGHFPKFPEEGYGTEVALSTKIANYLSLKVGDEVLVFFIQNPPRYRNLKITGIYETGLEDFDEKVILGDINLVRRINGWGENTIGGIEVFLNDPETMDEAETMVFEATSSDLYVDKVSDKYVQIFDWLRLLNRNVVIFFSLVLFVAAFNMVSILLILIMERTQMIGVLKSLGAANGLLRRIFFVNGLGLIVRGVFWGNLLGLSFCWIQDRYKLIPLDPANYYMNHVPIQFDPTAVILLNLFVIVMTAIALFIPLSVISRINPIKSIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ4</accession>
    <name>A0A654DVJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="27460" checksum="079331003B9E795A" modified="2020-04-22" version="1">MSLKCLIVDDENIARKILSDYVSKVPELELVATCSSALQALNHIKNGTIDVLFLDIQMPDLTGLDFLKILPNRPATILTTAYSEYAVQSYELDVVDYLLKPIDFERFYKAVTKVISSKDHKVDYPPNSPSVQTTDKLFIKADNKIIKVAFHEIIVINADGPYVQIFTADGRKIMSLQSMHKLEELLPKNFYRIHRSHIVNIDHIDSIDGNMIRLKDQTAILSKNKRDEFLKLIDQLNLLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL2</accession>
    <name>A0A654DVL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="76" mass="8932" checksum="8F8F05752DED6EF3" modified="2020-04-22" version="1">MVLTWAYRRIRDHYILNGLKKSEIGREIILINFKVYNQHLIYFYENAENCHTTSGARFITSGDGSERVCHHQCRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW0</accession>
    <name>A0A654DVW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="15231" checksum="D90F23773A780F15" modified="2020-04-22" version="1">MRKSSRLIIVALIALTYAFPAFCLGGGEEANFQTLSQKLENAIEERNFHEAREAIEELMPLMKEELKKDKKTLSELKREESPEMDPTEFEKKLVRKTELYDALKELVNISPAALRVKSERIKTDVKEFIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW02</accession>
    <name>A0A654DW02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="18774" checksum="6E5147B28F0DE45E" modified="2020-04-22" version="1">MADSITKSIFEGRVRVRVCGILQEENAILMLKHKGIGPNGHLWSPPGGGIEFGENAEDALKKEFLEETGLTISVGQFLFVNEYQDDRHHAIELFFEVTRLAGEIQLGADPELPKNKQILEELRWLSFDEIKNMDSGFLHNAFGLTQEPNQITELRGFFKFANISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWA4</accession>
    <name>A0A654DWA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024833135" evidence="1">
        <location>
            <begin position="20"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="573" mass="62423" checksum="E23D7E8414E6A5B9" modified="2020-04-22" version="1">MIFKNIKFIYALLLVGVFACDPMQDVYDDLDKGSTGGVTSDVAFTMTEDDFELALPIAENGSDSSSMNSFYNFSDEQARKYIPYILSKKFPQLAKGSSANVTYAQYQGSSSTANTYSRASVYTLDAEDYESAGESVGMAGFFSPSYPASAYVPAILLAEVQDPTEDQVYGVSYKYSVTDPEFDYENAGDQTVYVEGFTEDISAYTVKEVSGDLAVWTYVIFSDGSAQGSGYSGGAQENEEWLVSPEIDLSGLTEAKLHMSHVTRFLDGNAVSDFLNVKISTDYTGDIATATWETVSFPDWVDGGSSNTAVEVEAMIDAYAGSKVTLAFAYKSSSTIAPRWQLAEIKVTTPGSVGVIAEDPTNMTDYYSYSGGAWSKDNGAYYLTAADYDAMGAPGQYDNFSSSVPADPYIITYLKTNYPFAQEEDELVVVYKYYSSSAGATQTRSNLYTVVGGSWTAYSAVIDATLLFAFDGTAWVPDNTIKITFGAPDYTWISENFKDKNPGGSSNMGTYGNFSCFEWSDDQIFDAITSRLDVIYSSIEEGQKYQVTYSIYCGASSEPSLAVIYQGGAWEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE1</accession>
    <name>A0A654DWE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="118" mass="13544" checksum="1BEDC59555D3586B" modified="2020-04-22" version="1">MTKLAPEVWVFGLLLKIDVYCVFYQSQFFRLYTLLETQVSSGAGDGYYFVILVEVFPNPSLIKFGWEGNVQSMNGYIHGHAGKKKQRGADEGHEPIIDIDTLDLRIPFESDQNPKYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI6</accession>
    <name>A0A654DWI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BetR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013975">
        <property type="entry name" value="Tscrpt_reg_BetR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08667">
        <property type="entry name" value="BetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BetR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="39248" checksum="73E4D361326E4A27" modified="2020-04-22" version="1">MNSDRDIQISFLEWVKTQKPEGKFVEELETLLDISKDSAYRRMRGDTLLTFNEIRKISQHFGASLDTFFNLSKDTVLFHKRMLNVNYGYLDFLKSVLASVKMIQEDESYHMTYVAKDIPPFHYFRFPELSRFKSFFWRRTILKEPSLMNQVYGPNVISKEMLDICAEIWNAYQQIPSLEIWSDETINITLRQIEYSYETNMITSDQFRTLVDDIRSLLTVINKEAEEGHKMHPDNSQRLINGKFDLYYNEIEIGDNTVFFSLGNRRMVMKTYNMLNLLNTTDHAFCENIEQYIKNILQKSVPISNSSEKERLKFFHKMNQKVDLFEQKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR1</accession>
    <name>A0A654DWR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024930419" evidence="1">
        <location>
            <begin position="20"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="801" mass="90038" checksum="A752AE30F42962D4" modified="2020-04-22" version="1">MRLKLFIVLVFGVNLSAWAQDLCVNQIQGQVLDLDTRQPIPYVTVIVKEEPGKGAITDAQGIFEIKGLCEKEFTLVVSHVGYKEASHHHDSYHDHPTILLASDDHLLESVVVEGIYNQTSLQTISIDRLSSEDFTAAQSESLGELAGRITGISTISTGQNVVKPIIHGLHSNRVLIVNNGVRHEFQNWGIEHAPEIDPSLAGSVEVVKGAATVRYGPDALGGVILVNPPKLELGAGFEGTAGVVAKSNGRSGEGDLQLSYGSDNLVVAVSGAMVGQGDLHTPDYVLTNTGKQEYSYASSLRYHKHSFDLEGYYSHFYQSLGILRGSVNGSLEDLANAMESEVPPGTSPFSYDLNNPRQQVTHDLMKLKGGYVWDNQDISFQYAYQLNHRQEYDVRKGTNNEIPSVDLKLATQTFEVDWNHPDLGHVNGNMGLQWFYQDNNNVPGTNTVPFVPNYNVMRAGLFAVERLEAGSTTYELGLRYDFQYNSVRGRAPSNEIYSNELTYSQLTGSAGLKQNLKNHLNFRSNVGLAWRPPNVSELYIFGKHQASIEYGLWRYAYDNEGKISVSEVLSEEDKPVKPEVGIKWINTLEGEQDGNHWELTAYTNVIRNYIYTRPAGITNTVRGAFPYFIYDQGDALFWGLDAAYRLELTQFWKIEAKSSYVWAMNLKERETFTNIPPARVDVGLDYERKPDFLSSSRVALGLSYVFRYFQEPRVITVREILEAEAEGQDLFVENNEMFDFMAAPDGYFLANLSWSAAVGKWEWSARISNLLNKRYRVYTDRLRYFADQTGRNVQLSLRYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS1</accession>
    <name>A0A654DWS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="41064" checksum="8767A910752A9803" modified="2020-04-22" version="1">MGLKLVTLVDKIDERMSPLQRSCEEHGLKLEVVGVGTTWKRNAFKFRVLEKYLQSEGVDDDDVLLLVDAFDVVMNAGESDLMERYLAQNADVVFSAEANYYFREADLSLKYWRIYPRQEGSVYHFLNSGTFMARASALKALLSEISVTYGVDYQDDDQLYQVRSDQYLYSRYYVDATLGLVHPKFTIKLDSEQKLFGCSGGRMCVASWGRVSEIQDYLFFKYERRMLKTFWIKETQENCRDLSFSGGQFHNTFTGSSPAIIHLPGTYTRFETVLNKIKGKPTFNRWTWARPLALVLSFIAFLRSVVNFWYISRVNQGVTEIKAIFPLQKGADLTRFAEGGYFRSGKCYPKDNPFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS7</accession>
    <name>A0A654DWS7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">MARINOS108_11107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="23181" checksum="3F0114D11DB5E1F8" modified="2020-04-22" version="1">MKSVEIIGYKRANLGKTEAKRLRAEGMVPGVLYGGEEQIHFYAPMILFRELVYTDEAHFINLNVEGQIFEAILQDIQFHPVSEMIVHVDFLQLFRGTKIKMNIPVHPVGTPPGIQQGGKLIKKLRFLTVKALPKDMPEHINIDVSKLGLGKSVKVGDVPTENFEVLNNPLVTIMGIEIPRALRGKSLEGEEEGEEGAEGSEEAAEAPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX6</accession>
    <name>A0A654DWX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">bioA</name>
        <name evidence="6" type="ORF">MARINOS108_11156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="301"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="423" mass="47628" checksum="FC42DC89609FE872" modified="2020-04-22" version="1">MLGLNNFEKADHKNIWHPFSPLAGNKPIGIKKAKGVYLYTQDGRKIMDAVSSWWVNIHGHSHKRINKALSRQAARLEHVIFAGFTHKPAVDLSKTLKRLLPKSIDKIFFSDNGSTSVEVAIKLAVQYWYNQGKPRKKIIALEGAYHGDTFGSMSVAERNLFSAPFNELLFEVDFVPFPKGDGAEAIARMKELVTEETAAFIFEPLVQGAAGMQMYAAEVLDKLIDIARSREVVCIADEVMTGFGRTGKMFASDHLRNDPDLFCLSKGITGGYLPMGITAVNERIVKAFDVEDRTKAFFHGHSYTANPLACAVANASMKLLLGKKCQQDIQRISEQHQAYLDQFRFHNKVKEIRHCGTILAIELHADDAGYTSNLKEKIYDFFMARDLLLRPLGNVIYILPPYIITDQELQRLYKAIDVFLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX02</accession>
    <name>A0A654DX02_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mutS</name>
        <name evidence="7" type="synonym">mutS2</name>
        <name evidence="10" type="ORF">MARINOS108_11240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="717"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="528"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="344"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="792" mass="89676" checksum="965D1DD36AAC91E7" modified="2020-04-22" version="1">MLIYPKDIQEKLGIDQLMELIRQRCKSDFAVEFLEKARPSSRIEEITKWLDQTDEMLRVISSGDNLPSRDFQDLRVFLKKIKVKGTFLQAEDFAQLKSLLALLYDWTQYLKKHQEVYPELCSLTYGFIADQNLIKAIELIVDEKGVVRDNASPELASIRALLIQKERAVRTAINKVLRKAIQDKLTDEDSSVTIREGRLVIPVKAEHKRRIQGFIHDESATGQTVYMEPTEALQLNNEVRELQYQEKREIARILTRLTDLVRESVEDLDKGAFFIGLLDFIHAKAVFSKTIDAVKPGVTKNPMVKWYGARHPLLWLSHTASGKPTIPLSLELSRQENRILVISGPNAGGKSVALKTVGLLQYMFQCGFLVPASEASTFGVFRSVFLDIGDTQSLENDLSTYSSHLTAMRYFDEMADRNSLFLIDEFGTGTEPQFGGAIAESILGQLNARKAFGVVTTHYQNLKKFAENHPGVVNGAMKYDVGALEPLFELEVGKPGSSFAFEIAKKIGLPTQIIENAKGFVGTSQVDYELLLNSLESERNKFQKLTKKLEKEEKEVISIKTDYEALKEMLQDEQKRLIKEAKARANQIVEEANQRIENTIRGIRESSADKEKTRRLRSDLEHYKKTQEESIKKEEKRKKAEEIKVGQHVTIEGQDTSGEVMNVKGKQAQVRFGNIISFIELSRLRKASAQAARQESRARKIGGINMIEKMSQFNGEIDVRGVRADEALQKVDEYIDQALLLGTDQVRIIHGKGHGILRDVIRNYLKSHQSIEKAVDEHIEFGGSGITLVTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX90</accession>
    <name>A0A654DX90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8592" checksum="E42B2119399EEB8F" modified="2020-04-22" version="1">MSLPFTFTCNDHNKSVLIIEGVRNNWKPDPVQVVDYSFDFLNRSAFNTAKLASTFEVRNIPYHWKKGKLETWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ7</accession>
    <name>A0A654DXJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6548" checksum="EFB9112E1D3BB310" modified="2020-04-22" version="1">MAYSPQRSQSLNETFFGFISFYQSISWSKEDTSNHYFFTNVYNVHIKDSRISLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL5</accession>
    <name>A0A654DXL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="47" mass="5257" checksum="42023FDED883CFD5" modified="2020-04-22" version="1">MGIVTLISSKSKTMPYYIDLPYHLSDGTTELTMTDGKKMPVIESESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL9</accession>
    <name>A0A654DXL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="12292" checksum="C52D606DDE1DAE93" modified="2020-04-22" version="1">MRQDEIDQKLEEALKRPLEVSMPAGFSDRVLTKIHQREAAMDSSMKWVYGLAMSGFLLSGLICLVIFADKDSLALLPEMGLWGLLIGVMVMVFQWLDHKLVRKKTQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM8</accession>
    <name>A0A654DXM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="9241" checksum="EF68463AF1B779E5" modified="2020-04-22" version="1">MKKILMHGIYIVIIAFFVVFANIKASEAQKSVQTAEEALSKVEVAQADAVKQAKISEDLATEKIKALYSAQKIKDELEACKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS2</accession>
    <name>A0A654DXS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="154"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="31189" checksum="EF24812C69C7AD29" modified="2020-04-22" version="1">MTIKSSWFFYALVTTIFWGVWGAIIEIPEKNGFPATMGYIAWAITMIPCAFVALRLIRWKLDTSLSAIVLGSIVGLAGAGGQLLLFQALREGPAYIIFPIVSLYPVLTIVLSMAILKENATTKQYIGIVTALIAIFLLSYSDGETTSMVGYAWLLLSTCVFVLWGLQAFVMKFSNERMKAESIFFYMMTAAVALSPVAFAMTDPATPINYGFSGGGMALLIHFLNSIGALTLVYALRYGKAIIVVPMTGLSPVITIILSLLIYAVWPQTTLLVGIAFAVVAIYLISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY11</accession>
    <name>A0A654DY11_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="397" mass="45541" checksum="93702AC369DA6262" modified="2020-04-22" version="1">MSIFYNDLYNFRLKFVVFARMTKIITWTILSFLCWTNTFAQKDTIIQHTLDSIRTSSDYPGLVFTFIDRDKNVHAFASGWADKEQGIKMTVDHKLHGGSTGKTVVSAIIMQLIEEGEITLDDSISQYLGKYNWYSRLANADQITIKNLLQHTSGIVRYEFKEAFLNDLTKDPDKVWKPEELLAYVLDDEPPFEPGRGFTYSDTNYILLGMTIEQVTGNTFYKEAEERVFTPLGIESFSPTNNNQIDNMAQGYYDEGTDYALGFKAPFLVDGKAQNNTQFEWTGGGYAYKNADYAKLLMAIYEGELFDMEALGNAFFDFVEAEEIRGKYGLGVIRYEYPEIGAFIGHSGFFPGYYTMGFYHPETGQAFTMQVNCTQMPQLKNFRDDYLRLIRLSLSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY15</accession>
    <name>A0A654DY15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Four helix bundle sensory module for signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="24752" checksum="36C197D4A0C3EBD0" modified="2020-04-22" version="1">MKWKNILNKQQSAGLAMVSVFIMVLVISIMNKRHVLDLEYSLTTIYDDRLMAENHIFNLSKKIYQKKILLNVDEDRLMMSRIHINDSINLLIADYEETKLTMDEAFQLKKLKSSLGKAELFENQFVYSSSAEHRNLLNPELRAQYEIILADLEGLAMLQLHEGQKLIDQSHRIAASSNVTTRLEVGLLIILGLMTHIIFAARPPAPKYSYFDNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY74</accession>
    <name>A0A654DY74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="19671" checksum="47A2271215A331B4" modified="2020-04-22" version="1">MKKLIYIPVFLIIVLISCSTNNYSEQILGTWESSVFIDEAKAKAMFKVEDGMEMQATFTTTEQYLRGGRYNAEGDVTFRVSANGQEIPIKLHLRESGSWEFHDNFLVTIAEDSKVTALDEVTRNIIDNAPEFAEMIEPVKGQSASTEIVSMTDTDMQVKMEDLPGILVTYQKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY99</accession>
    <name>A0A654DY99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipopolysaccharide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="368" mass="41608" checksum="BB44FDFF512C2F4E" modified="2020-04-22" version="1">MLEVNHLSKSYNRSEVLNNVSFKLLSGDIVGILGENGSGKSTLLKIISGIVAPTAGDVRYVGQLSSLLEIGSGIQPDLTGEENYYLKGELLGLSRPDLKNRIGELNQFTELAPWMNHPVKHYSDGMYMRLAFGIALTLEADIYLFDEILAVGDTKFQQKCFETIINLSQKGKIIVLVSHNITELERYCNRFIWLKKGEVREQSDSPQVLDRYLRDQLMGSDPNKILPWQHASLAFSQLSITNEQGEQRLTNTNEIWFAAEFQILKPLSVFNVTMHIQDHSGLPIFSISTSTSAGWIHEKKPQNVKLSTFVESGFLNAGTYTVSFYIQIESRVFQLRNLFFLGVSQSESDTQSHLFSGKIRTNFQWKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYF3</accession>
    <name>A0A654DYF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two component regulator propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024989777" evidence="5">
        <location>
            <begin position="18"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="847"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="1116"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="1264"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1366" mass="154470" checksum="89B947BF2F590ED3" modified="2020-04-22" version="1">MGVLGLMFCLASTCAVAQYQNLKFESYSTLEGLSSSTCTEIFQDSKGFMWFGTIDGLNKFDGYRFTIYRPEYGKINSLGGNRITAIVEDDDQNLWIGTSTGLNKFDQKTEKFHQIALSKADEKSSLVSVNCLLYDEHTLWVGTSTGLVEVNLSSGQDHLAYQSYDSSPDSKYPLDQEEVVGIISIDSGVVVGTEGSSLNIINTLTESIRHIPSAGKADFEINQLPKSFLMDAKGELLFGNDLSRMYVYNFERGEYRSMNYTKGMAVPVFDIYQDNQGVIWISTDGYGIFLLNKNKELIQQIKHDPQDPSSLPNNQPSKVMEDGEGMFWIATYNEGVCKLSMNKSAFAHVFYRQGKNDGLSSRIAQSVMEDSKGRIWVGTDGGGLNLLNDELKIVSSSRHQEIGKSSISSDKIVYMEEGLSGQLWICTWDGGLNLFDPDTQRARRFTYDPNNEYSIGQNSVWYATQADDGILWCGTLSAGLNAYDPREDKFYRYNSQTIGQQLLSDLVFSLLIDSQNRLLIGTDAGLQVLNLNRVSDLSEMTSLPLVNTENAQLRGFRINHITEAKDRTYWVGTDLGLYHLSTDFELIKRYTTSDGLPSNLIVGVVFDEEENLWFTTKSGLGRLDIAREDFKNFNIHDGIQGMEFQSKSIFRTRDGRLLAGGINGLNVFRPEEVHLSEQVGPPMITSMSVLNHTVRVGEIFNERVLLDAPITGQSKVVLNYDEGFVSFDYVALHLPNPDRVSYAHRMIGVNEDWVYVKNNRTASYSNLISGDYRFEVKTALDDDWENAKLTSVDLEVLLPPWRTWWAYLIYNILIGGVIWIVFRVYSQRIREERQHELDQMKLRFFINVSHEFRTPLTLILNPVDKILSSTNDEEVVRDSALVIQRSARKLLSLVTQLLDFRKMDLGKTPLELVEGDLVKFCKDTFLLFEDLARSKSLSFRYESPSDSLKGYFDPDKVEKIITNLLSNAIKFTDPEGAITMSVTPLSMGKKDYVRIVVADTGIGFKKEQLKEVFSRFFHVDSTKTGTGIGLNFTKGLVEIHKGEISVESEYQKGTSFIVDLPLDKSLYKDVEHRAMGEGYAQDPAAVLSTAYELAISDNQTITDESLDEASTLKSPTVLIVEDNKELRVHLRKELRSRFKVREAANGKEGLEKINKYYPDIVISDVMMPEMDGFEMCRQAKVNIETCHIPIILLTARSLEEDRIEGYQTGADEYLPKPFNISVLKARINNLLEAKNRLREKFTSIGGMLPSSEITTNTLDEAFLDKATKVILDNVSDQDFRLAELLKEMGASRSQFYRKVSSLTGQNPSHFIRVIRLKYALDLLRKQQHSIKEVAYMSGFNSSAYFTKSFREHFGKAPNQYLAEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ3</accession>
    <name>A0A654DYJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="38821" checksum="A21B013FFF4753C5" modified="2020-04-22" version="1">MDITNRFSENPILTPKMVKPSTPSVGIECLLNPGVFRFQGKVWLLVRVAERPEQQEGTTTLPIYNQAGQLELMTFRNDDPKFDDSDKRVFEYDGAHYLSTLSHLRLLSSHDGIHFSEDPEYGPIFPLGEQETFGIEDCRVSQIGDTYYLTYTKVSPTGVGVGLITTTDWKHFDRKGMIFPAHNKDCALFEERIGGKYFALHRPSSPSIGGNYIWIAQSPDLEHWGHHQCIATTRAGYWDSARVGAGAAPIKTEAGWLEIYHGANENHRYCLGALLLDLQDPGRVLARSEEPIMEPVAGYEQTGFFGNVVFTNGHLVEGDTVTIYYGASDEVICGAQLSIKEVLKSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK7</accession>
    <name>A0A654DYK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="31387" checksum="2C4F7BB03A07822E" modified="2020-04-22" version="1">MKRLSLLIKTAFLPVFMLMLGWGELKAQSANVTLNHGDGWYRLILGGHPRAGGEISIYGGLGNNKLTLIKLHATFMGYSQYGSIEIVENLFYNGNHVDAIRSGTIGGGLSALDFHFVGITGTPTVVVEVDGINMTIADPPEYEPVAPTGVTNISGRVLGISSVQWPVYFGNKVGIGTSTPSEELEVNGTIRSKEVKVEAAPWPDYVFSADYSLKSLEETEVFIKENNRLPDMPSAKEVAENGIALGEMNAKLLEKIEELTLHLIEKNHEIKELKSQMSEVLKELKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL6</accession>
    <name>A0A654DYL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannan endo-1,4-beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024973522" evidence="5">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="48"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="401" mass="45662" checksum="625EC1D126388DC8" modified="2020-04-22" version="1">MLRALFVSIILLSSFILSCEDVEEPHIEEKKDELEKVTLTLVDNQATEETRALYANLWAIQEEGFMFGHHDGLIYGRDWVSEPGRSDVKEVCGDYPAVFSVDFAQIMDDRKDNGQPLNAATTVERRQAILDARRRGEVITACLHINNPLTGGDSWDNSDQTVVRQILETGSEVNVKYKGWLDNLADFVNNLKDDDGKLIPIIFRPYHEHTQTWSWWGRACTTEDEFISFWKFTIDYLKDEKGVHSFIYAISPQLDAAATTSSLLFRWPGDDYVDFIGMDSYNGTNTNALATNAENLAKLSQEKMKPCGITETGIEGVRNGGQEYSEYWTNEILKPLAGEGVGMVVMWRNKYDPLRTGHHFYGPWIDHSSAANFQTFYESSYTLFSVDLPDMYEMVEDITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ44</accession>
    <name>A0A654DZ44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="50"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="572" mass="62421" checksum="9180E89F258786EE" modified="2020-04-22" version="1">MNHLCTNVHSNYTDNRLNSHSSLPKYVPVLITDDLFTMKENDILRIDPKDNVLVALKELTAGTVVDMGLSIEVKETIPQKHKMLLEDLVKGQQVIMYGVPVGVVQKDLPAGSLLTIENTKHFAEPLSLENRKKYTWQTPDVSKWAGRTFSGYHRSSGKVGTANYWLFIPLVFCENRNLKVIEEALIKQLGYYKPNKYESLVSKHLSGQVTQTTYATEQVFKHIDGIRFLYHHGGCGGTRQDAETLLRLLAGYVHHPNVAGATVLSLGCQHAQADWFRSLQKELYPDSEKTVLYFEQQQMASEEELISLAISETLEALKQANETERKPATLDKLVLGLECGGSDGFSGISANPVLGRVSDLLAVLKASTILSEFPELNGVEQNIIDRCESQELAEKFVRIQRAYESHAQAVGSGFDMNPSPGNIRDGLITDAIKSAGAAKKGGSAPVADILDYTEPVTRPGLNLLCTPGNDVESTTGLAGSGANIILFTTGLGTPTGNPITPVIKVSSNSTLAARMNDIIDVNTGGVIEGTKTIEQAGDELLEKIIAVASGEQTKAMKLEQNDFIPWKRGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC8</accession>
    <name>A0A654DZC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="21713" checksum="9143475DA9D43904" modified="2020-04-22" version="1">MAGRPKIFDEEQALDKAIAVFWEKGYENASAENLLKAMGIGKGSFYHSYKGGKQELFEKSVNRVGSHYMKDFKQALRDSARPTEEIRKFFYAVADPESQFGKFGCYFVNAVLQVDDEHLKCVAANQLDVVRQLFMEAIDREKNAGYLKTALSTELIGLHLQSLWAGVNVIRNAGRSAKEVREVIKLNLEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK8</accession>
    <name>A0A654DZK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized RNA methyltransferase BT_0643</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_12161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="52650" checksum="0C48BA7695D77A4A" modified="2020-04-22" version="1">MKASKVIEKLEITGVSSDGKSVGRHENRVIFVANGAPGDIVDVRIVGKQKKFLLGEIIHFHEKSADRTDPFCEHFGTCGGCKWQHIQYNAQLKHKQDHVAHNLAKIGKTALPELLPIKGSANTTYYRNKLEYTFSNMRWLTREEIEDNDELSRNALGFHIPRRFDKILDINHCWLQGDPSNQIRLAVKAYAEKNELTFFDLKKQEGLLRNLIIRTSTTGDLMVILQVFYEDQSAITALLNHLKDSFPEITSLLYIINPKQNETFYDLPVHTFHGEGFIHEEMEGLRFRIGPKSFYQTNSIQAYELYKVAREFAGLTGDEVVYDLYTGTGTIANFVAKKAQKVIGVESVEEAIVDARINSELNQITNTTFLAGDMKDMINADFVKKHGHPDVIITDPPRAGMHQKVVEMINEIKPKKLVYVSCNPATQARDLELLSPVFEVVAVQPVDMFPQTHHVENVMLLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR8</accession>
    <name>A0A654DZR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="312" mass="34273" checksum="563C4F77370CF4EB" modified="2020-04-22" version="1">MYDVLVVGELNVDIILNRIDGFPEVGKEKLSKDLRVVLGSSSAIFASNLATLGAQVAFVGKIGKDQFGQLVETSLKQKGVGTQFLVHTNDHQTGATVVLNYDMDRAMVTYPGAMEHLTEKEVRNDILTEARHLHVSSVFLQPNLKKNLVQLMERAKSFGLTTSLDPQWDPAEQWDLNLQELLPVVDVFLPNRSELKHLTKTNSVHHGIDAIRDFANIVAVKDGENGAILYHEGETIRKPAYLNKEVADCIGAGDSFDAGFISQYIQGKDLQTCLDFANLVGAVNTTEAGGTAAFQDLNKVKSIAKERFSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS1</accession>
    <name>A0A654DZS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein AsnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnC</name>
        <name evidence="5" type="ORF">MARINOS108_110030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD15854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17719" checksum="1D02944749E5F1EC" modified="2020-04-22" version="1">MSKNYEIDNVDLKILNLLMEDAKIPYTEVAKKVFVSGGTVHVRMKKLEEMGVVKGTTLQMDYSKLGYDVTCFMGIYLQKSSLYDSVVEQLKDIPEIVKVHYTTGNYNIFIKIHCRDTKHLKDVLHDKIQKVDGIERTETFISLEESLNRHLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU6</accession>
    <name>A0A654DZU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Cyclomaltodextrinase</fullName>
            <ecNumber evidence="2">3.2.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.54" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047798">
        <property type="term" value="F:cyclomaltodextrinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045829">
        <property type="entry name" value="PKD_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19408">
        <property type="entry name" value="PKD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="389"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1049" mass="115633" checksum="480D111B7775C0CE" modified="2020-04-22" version="1">MCLLTGTTGMAQVPVKLYLDSPYGYTESVYLTGNINGWAYQNEAYQMVGPDARGLFSITLDLTENSDLTYAFDVDSGPYLSDPFNSLDPVYDGFSQLAIANPMITYLLPQASRQQVPTPMDSIWALLAFKNSQPITESSISLKLNGVEVPDAGQYYDAVSREFVYYPGDLPAGEYVIELSVSSSAGTAVRSVTVQRAPAIMISNKISRYFSEEVTLYGRVTSSEITEFELEVNGAITTVSVSDGEFRAPVTLVEGVNSIVAAPGTSNSVSKEIEYVSLNKPQLAVTAAVTADLQVDLVVNVTNPGEETLTYEWTQVYGPEPAQWSTTNATATQVTLSVEDGDYHFRVTATNTRDEKFIAGQLVSVREGKASLISRFDPSPWMEKMVIYEINPRSFSNAGTLSGITAGLDELVDLGVNTIYLMPIFESNEYSGYWTIDYYELNELFGTKEDLKNLVDVAHEKGIRIFLDLSNSHTSTFNPYFEEPVAIGSDSPFSNFYNWSGPPALDNYTFSLSYSIPDINYNDPLATNYMLWVSEYWIREFDIDGYRGDVSWAIYKRNPAFWQKFRERMKNVKPDLFMVSESFPPYDQVFNDGFDAVFDFNLRGYGYEDANIITNLFNGSGSLDELDAVIRFDYPNAGLPVRFADLHDFDRATMSFGLAKARLLQSLIFTSRGIPFIWSGSEYGVDKGAYNYEVYARNDQFGLREYMKKLMDIRARYISNSSSMDRIENSNNTEVYSTAIKTGGDFVIAVHNFSGSEKTGTMDISALSLNCRSSFILTNLLDDSQEELTYDELQSYAYTVSAYGSLFFHIGEGDPSAVAIEGASEACQTKSLAYSIVEGFDSYLWSVSGGEILSGQGTSSVEINWSDEGAGSAEVDFTMGGGCVTSTSLEVMIAPAPVATITLEGDLLVASEGASYRWFQDQVVIAATTRQIEWVSGATYQVEVTNGAGCSTLSGEISPKVLGLDESTFKAILYPNPTTDEVNIQLNSLGSEPVVIAVRNLAGQLIQSSVFQGKDQATYRMDFAGYTPGIFVLDIQAGGLHQVYRIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ2</accession>
    <name>A0A654DZZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase YhcX</fullName>
            <ecNumber evidence="3">3.5.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhcX</name>
        <name evidence="3" type="ORF">MARINOS108_120273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="231"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="515" mass="59300" checksum="78F47CBB9AB2B9A7" modified="2020-04-22" version="1">MTNKKEPVLSGELNVQLRHLQLSDYPELREIMELAYKGIDEPYWERMDIKRLLKIFPEGQLCVEVDGKMVAAALAIIVDYKKFGDNHTYKQIVGNDSFSTHDDAGNVLYGIDVFVHPDYRGLRLGRRLYDSRKELCENLNLKSIVAGGRIPNYEKYAKDMTPRQYIDAVKNREINDPILNFQIGNDFHVKKILKNYLPGDSKSKDYATLLEWNNIYYAETEKLINAPRTYVRVGLVQWQMRPFKDLESLVEQMEYFIDAFGDYQSDFILFPELFNAPLMAEFNHLGEPEAIRGLAKYTHALREKFTEFAISYNVNIITGSMPEIENEKLYNVSYLCRRDGSWDSYKKIHITPSEQNSWGMTGGDKVKVFDTDAGKIGITICYDSEFPEISRLYAEQGMQILFVPFLTDTQNGYNRVRYCAQARAIENECYVAIAGCVGNLPKVNNMDIQYAQSAIFTPSDFAFPTNAIKAEATPNTEMTVIGDLDLELLKELHEFGSVRNLKDRRLDLYNIKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E045</accession>
    <name>A0A654E045_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="20579" checksum="929CE6F39DB2AA53" modified="2020-04-22" version="1">MFNFKEIISVSLILFSVIDILGSVPIIIDLRKKAGHVQSEKATIASGALMILFLFLGEGILNLFGIDIGSFAIAGALIMFFIGLEMVLGIHFFRSDHEDLSSSSIVPLAFPLIAGAGTLTTLISLKAVYATTNILVGIVLNLIFVYLVLKSSNWLERKIGAGGFNILRKVFGIILLSIAIKIFKTHLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A3</accession>
    <name>A0A654E0A3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ORF">MARINOS108_11258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="59"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="23503" checksum="5C5A37CF1C0D7DB2" modified="2020-04-22" version="1">MPVQQYDNQVAKEIAKALLNIEAIKISPKAPFTWASGWKSPIYCDNRLSLSYPETRSLVKNHLAKVIREKFPNAECIAGVATAGIPQGALVADALDLPFIYIRSTTKGHGMENQIEGVASKGTKVVLIEDLVSTGGSSLQAAEAVRTAGMEVLGMVAIFTYGFGISEENFKDHHVDLWYLSDYSTMIAAMLADGSIAPDQEATLQAWRSNPAQWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E0</accession>
    <name>A0A654E0E0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006478">
        <property type="term" value="P:peptidyl-tyrosine sulfation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PTHR12788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="305" mass="35515" checksum="95BB0550599918F2" modified="2020-04-22" version="1">MRRIKLARTLQRISDFLPRKYPVKSRAGLAEQPFFVLGSGRNGSTLLNRMLNQHSELFLPSEQYFLGNSIIKYKLYNFLIWRDLMKVIAGELMKVTGSHTWDFSAEEIFDTLNTTDDKSLQSVLEVIFRTYGLKNKPTFSQWGDTTPLNTYYVPELLSVFPNARYLFLLRDGRDVVASYKRGGEAYLGKLAQPQQAAIHWVHALEQYQMLRKKSAVLLIRYEDLVTQPEVELMKVCDHLKVDYEDRMLTYHQTTPTAPMYQEPQHAKILKPVDKSSIGNWQKVLSEEDLKSCTIMNPWLAKFDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P1</accession>
    <name>A0A654E0P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="386" mass="44425" checksum="EF3FFD9CD370846F" modified="2020-04-22" version="1">MFSIVDCNNFWSPSGGGVRRYHLEKMAFYKDRQDVKYSFVMHDSETWTEQIGENAFIEHLKVPKVYGNWEYRYLTRSAPLEPILRRINPDVIEVGSPYFMPGIVRKIVRKHRLRARTYGFWHADFPVTYVKRFMEPMGQGMAKMGERMAWKYARKNYNQMDGVVVSSRLIMDRMERNGLKNVHFLPLGVNEQLFNPGRRDVGLIAELKKGNEDRLLLFFPHRFSKEKGLDVILKAYHMMCEGLDHEPVLIIAGAGPYEHLAREAGEKYEFVELRGFIEGKEEMARYYASADLGFALSKWETFGLSLLESLSSGLPLIAANEGAAYEHIDTSGAGTIIKEVTPEAVARAVIEFSLMDAKKMREKARAYAEPLTWESCFENQLAIYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U5</accession>
    <name>A0A654E0U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rplA</name>
        <name evidence="10" type="ORF">MARINOS108_120509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="24841" checksum="EDA5D783E2A5755B" modified="2020-04-22" version="1">MGKITKNQKKAAELVDVNKEYSIEEAAQLVKDITFSKFDASVDIDIRLGVDPRKADQMVRGVVALPNGIGKEVKVLVLCTPDKEEEAKAAGADYVGLDDYITKIEGGWTAIDVIITMPTVMAKVGKLGRVLGPRGLMPNPKSGTVTMDIAQAVTEVKAGKIDFKVDKTGIIHTSIGKISFDPEKIMQNAVEMIQTVAKLKPSSAKGTYFKSITLSSTMSKGIAVDKNSIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V4</accession>
    <name>A0A654E0V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="275" mass="31419" checksum="24AC804A7EF7F695" modified="2020-04-22" version="1">MIRALKLEWLKIRDYKTFWVLLGMYVLALLVICFGGMFLLEYLKSKGADFNGIDPTILPIYDFPDIWQNTTYLGSFLKVLLAFIVIISVNNDQAYNTLRQNVIDGISKKEYLASKLLFIAALALISTLFLFLSGMINGAIYSHVWGSQYILDELEFLAAYFFDIVVYCSLAFLLSLIIKKSGFVIVLLFLYTLMFEPILALILEESPWFKGTFWAEIAPFLPIKALNGLIPVPFPKYVFMEIVDNVPIKALLIATGWLVIYLSGILFLLNRRDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X6</accession>
    <name>A0A654E0X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase/DNA gyrase B/HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="231"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="457" mass="52362" checksum="D36AF0C7730DA9B8" modified="2020-04-22" version="1">MGYNKFRYQLIGRVILLGLTIFLFANLFYTESYTFSKILIFLLICVQGYYLFYSLEKSNREIIGFLQSIKWDDFSHTYPERKEGSSIDELYNEFNAVIKKFREIRAEKEASYQYLKTIVQHVGIGIVTFDAQGEVQIINTTARTLLGVKHLKNIKQLKVINEELVTTLRELRTGGRDLVKISKTDEDEIQLAIYAIELSLRGKEFKLISLQNIQSELEEKEMEAWQNLIRVLTHEIMNSVTPISSLARTIESEMEEWLDNGQDINQINNEQISDFHTALHTIHRRSESLIKFVGDFRNMTHITLPNLSQVCIKELIGHVVSLLKHDFQQTGVQLVQDVPDSLCIQIDEQQIEQVVINIVKNAIQALGEVDDEDIQKTLWIKASERPEGGALISIRDNGPGIEEEALKKIFIPFYTTKKSGSGIGLSLSKQIMRNHRGSIAVRSVINDGTEFTLKFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E126</accession>
    <name>A0A654E126_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gliding motility-associated protein GldL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019852">
        <property type="entry name" value="Motility-assoc_prot_GldL"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03513">
        <property type="entry name" value="GldL_gliding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="28523" checksum="9CEB626619828B21" modified="2020-04-22" version="1">MSKKGGFVELLFSTIMPKIYGIGAAIVIVGAMFKILHLPGSGPMLGIGLTVEAVIFFLSAFEPAHKDPDWSKVYPELADDYDGPAAAPRKVTSGGNNTGVAAGMDKMLADAKVGPELIKSLGDGMKNLADSAAKMAQLGDAALVTNEYAKNAKAASNSLVEMNKSYATSMQAMSAMAEASKDTKEYHSQVQNVTKSLGALNAVYEMELKDAQGHVKSMNKFYSNLTQALESMGEAGKETSAFQAQLNTLTTNIASLNKVYGNMLSAMKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L1</accession>
    <name>A0A654E1L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="212" mass="24361" checksum="D0C63CE6DB38C553" modified="2020-04-22" version="1">MRVLFLFLLCSLFLALSWYEGGEEHDGAVVGAAEKQIPNTQLVSTHEGLRKDSSGVLLYREVPYSGYLLDLDSEGQVILRQGYFEGRLEGEILAYYASGALRFKRPYRDGQKHGAHMAWYEDGQMKFLYHFDQGKSVGNHKEWYPDGSLFQDLNYQDGRPFGPQKIWRSDGKIRANYVIRENGKRYGLMGIKRCTKIDGEKEEIDPYKGVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R9</accession>
    <name>A0A654E1R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16538" checksum="C09FEA485168D6E1" modified="2020-04-22" version="1">MWTNLLFGTVAILIIESLIIRSFFMAVKRTIPRIYVVLAFAFFSVEVLYRQSVKRLDYLSVIGQLDNLELERAVRIRSIFGNSLMSEVDLITLYGFFILSAFMFALIFYKNRPLHIDFLNAAGISFLLGPILYLFRFFWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T2</accession>
    <name>A0A654E1T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="17790" checksum="CBE59F2BF7679F6A" modified="2020-04-22" version="1">MKKDYFQQHMPENVCFGCGESNEEGLHVQSYWEGEEAVCTWNSQEKYHGWANLLNGGILATLIDCHCMGTAMADAYRREGRSLDSAPTYRYATGTITVKYIKPTPNDHPIELRAQVAEVKGKKTVMTCTAQVNGEVTATAEVIAIRVYDSSTHHGANPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E220</accession>
    <name>A0A654E220_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="539" mass="61351" checksum="C35F6856D68C05CD" modified="2020-04-22" version="1">MSNRIYNVLFHTHTVSGLVISVALYVIFFAGSISFFRDDIIAWERNQPIKAQTQMNADFDQILDTLATRYGDLRGRTINIRQPHQERNVAVTIEPSQDTSATESAKRSVYTYLDTKTYEEGTYYSTYTLGEFIYRLHFFAQIPYPYGYLLSGFVAFFFLFAIVTGLIVHWKKIVSNFYLFRPWAKLKTVWTDAHTALGFIGLPFQFIFSVTGAVLIIGTTIMLGPASSLIYDNDRNLMYRELLDQPLSPGFANHPVDFDQSPNELVKRAQSSWNNAVLSRLCIQNYGDESMKILVEVRPQSRGALLGLGRATFDKTGVLIDQTDEESINYIVGVDQMMRRLHFGDFGGYGLKIIYFVFGIITCFVILSGVLLWVEARDRRSTVPWKRNANQWVASIFVAISLSMYPSIALLFSMVRLVHDAGDLAPHVFIYSMFFTSWLILSIGFAICRNNYLTSKYCLLLGSILGFAIPVVNGMVTGNWMWYTYNVQQLQIFVVDAFWFVTSLISLLVFLRLKTRLPGPLLEKEAPSEACELIEASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E232</accession>
    <name>A0A654E232_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="747" mass="85476" checksum="B9EC43128AD5484C" modified="2020-04-22" version="1">MRMTMKKLAFILFLAGATLPGLSQKLEKYEEVLPRILALPPSGALAQLKIYLAEQPDNSSIYLQMAVIYEKRYRESDPIKDFAYKVGNAREALKAYQRTEQFISEKEVRKNQEYFFNFGKLDDKGRVTVGFDTISNHMARVKVELQSFIDNVPLIYDKFTRSFSSYDRAHKAFTGILGKYPTFKDLYLLYDAEVDKTFGDIKKDYLECLQYWEEYKAATASFDVGYNQTMTAKPIKVYRLDGLESKINFLQPKIQVWDYASWVDTTREIIHAEIDKLREDLMAENLRLNKRIEEAKPDFIREEFEPLKVSKEVLFTLRKYDLSSVIEPIFIFKEKKHDLIYQQLLSEKLGADTEVDVERKLYLYGQMVNRIKEADSVLSDIRRTNTAASLSKYSDFIKTNYNGPSGITQLITTERQNNKNDVSNYVANIQNELYTILKTDSVIKKVKYKKLDIPLFRSVPVDNDLLTAAPITSHRIENFDGSAFIAGIFKNTKENKTQAFVAGITKEQTVGWYNDYLLKIDSSAGFDANTRIGAIQSVPGGLAVILNGVDTSGTRINHLLMLDEKGVITHSRRLILNQFPRTISYNERTNTLFVTYKGNDYLDDPLVESEMIMANYSIYGDLQWQQRMSYKGDITDVVSVDQAYIIVGNYNEIKGLDGRVNRAGKNNTDTKAFAVKINLAGELLDLKTIDYSSSYFANKTYKVSDDCINFFGSMGAYTKTVMLDSRPESAVHVIMNKDLEILASTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E239</accession>
    <name>A0A654E239_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008503">
        <property type="entry name" value="Put_Zn_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05618">
        <property type="entry name" value="Zn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_protease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16156" checksum="6FC7393EFE76A8EE" modified="2020-04-22" version="1">MKTKKTIGRADIVDFPDLGIEGVKAKIDTGAFTSSIHCKKISVKEGVLSFHVSIDQDGTTISKRFETTDYTQKKIRSSNGVAQLRYVIKTKIVLFGKAYPAQFSLTDRSRMKNPVLLGRKLLKGRFLVDVSEKNLSFDLKKTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E276</accession>
    <name>A0A654E276_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein transport protein (OMPP1/FadL/TodX)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025009619" evidence="1">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="532" mass="59083" checksum="DBE54CFFF1ECACEB" modified="2020-04-22" version="1">MNQFKYIMFAGIAISAWSASAQVADGSLGYYQDARIFSQTSPVYGSTARMQGLGGTQISLGADMSSAGSNPAGLGFFNRSVLSFTPSMTFNNSDASYFGNTISTYKNNFNFANLGMVFNSNKGDYTNEKFKGGSFAITFNRSNNFNSEVFYQGRNTSNSIVDSFVEGANNDLSDAYIDYAFGQFLIENADGYLYQKGADGRTYIYPDGDFDGYTSLVGANSYDGYLPRQIERITTKGGQSALNFAWGGNYDDRVYFGAGLSFESVRYSRIRTYTEDSFRDVDGNQDDLLYKIQIQDELTIDGSGVGFSGGLIVRPVDFVTLGLSYKSPTYYSLNDESGFTFATDWNENYSYYNGTNSEGDSVFYDMGSYKETSDLTMSQYNLKTPGKLSLGATFFLGKVGFISGDVEFVDYTRSQLKSNDFSVVADNQTIKNLYTNTMNFRIGSEFRYDDFRFRAGYAFFGDAFANNDSYDGRSQNVSFGLGYRSRDYFIDLAVVNRKSFDAYSPYQISTGTPIADIEQRTNTVSATIGFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G4</accession>
    <name>A0A654E2G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SiaC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="16371" checksum="E19EE24744CDE227" modified="2020-04-22" version="1">MITHYATDTTHLHGFIPKWTSNLMLDSTGATPFVSYDKETKFLIIKGHASDPHIQEFFDPIFSAVKRDTVDSKNLRVYFYFKSMNTGTVRVLFDLFKYLRVRVAAGTKVQVVWGADACDHEMMETGRELSELYDLNFRYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P6</accession>
    <name>A0A654E2P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="21582" checksum="BD3D610F952C2108" modified="2020-04-22" version="1">MEDRALVLDVLKGDQWAFRRLIDKYQRLVVHMVTRLVDDDRDREELCQDVFVKVYESLSAFKFDAKLSTWIATIAYRMAVNHLRKRNRKVEEQDLETVHFSVGHEDLSVETADYATFIHSLIAQMPLNYRTVLTLYYLEGFSYPEIVQVTEMPEGTVKNYLFRAKQKLKTLSEPYIGKEIHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E301</accession>
    <name>A0A654E301_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BatA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011933">
        <property type="entry name" value="Double_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02226">
        <property type="entry name" value="two_anch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="BatA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="651" mass="72486" checksum="AAE00CF8BAFEDED6" modified="2020-04-22" version="1">MYFLNPEAFWAFALLLVPIIIHLFNFKRLKKVYFSNLSFLTSIEQQQKSKSTLKKLLILLSRLLVLCFIVLAFSKPMLGDGLASDRERSVAIYLDNSYSMQQTDAKGEPLLYGAYSSIQTLLNEREQGTSVRMFDNEGQREFSLSESDEIIQEVKFSDGSLFLSDVVGRADYYGVDLLHVYGDLQRSTTLPIDKVLGDTLLAIVYHQLQSENSRNLYVDSVYLEKPMGLTGVNTLHFGIRNTGAERVENVLVKVEKGEQQLSAFTATIPGLDTEMLSLDIGVNEPLNGNYKISVQDNPVVFDNDFYFSISQAVKPLIVVLSTAKSAGRYFEKVFSNSDYFSLVSNSIENASFEDVVNADLLVLNGLDQIPDWLVSQVDQIDGKILVVPSGAAVPESYHSVLGFGLDVKRRTESGTLSKKSLDHPFFDGVFSEKNERAGLPNVKSIYGVMGFTETILGTNEGFPFLVKSGRKSTYLITSPLDDSLTNFHKHAIFVPVMYLLAQPLGVTPMSYRLGGGLIPLKMEGIAPGDILELRNSEDVFIPSYRYFKGEILLEIPDVISKPGIYHLVADSDTLKSIALNFDRRESEIAAIGTDEFERMIAGYDHIRLEQVDTGAALTSNTSESGENGLWKYALILALIFLMAETLLLRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E345</accession>
    <name>A0A654E345_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nusA</name>
        <name evidence="9" type="ORF">MARINOS108_20503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="413" mass="47446" checksum="EBFDD223B32372AE" modified="2020-04-22" version="1">MDTGILIDSFADFARGKNIDRPTMIRILEDVFRTMIRKKYKTDDNFDIIINTDKGDLEIWRFREIVDDNSEDIWDHDKISLTEARKIEPDFEIGEEVSEEIKLEDFGRRAVMTARQTLIQKIKDLEKDILFQKYKDLVGEIITGEVYQTLSREILLIDGEGNELNLPKNEQIPKDRYRKGDSVRAIVHRVEMSNGNPKIILSRTSPTFLERLFESEVPEVYDGLITMKNVVREPGERAKVAVESYDDRIDPVGACVGMKGSRIHSIVRELQNENIDVINFTDNLELYIARALSPAKILSMKISEEKDRVSVYLKPDQVSLAIGKGGQNIKLASRLVGLEIDVFRELDGLEDEDVDLDEFSDEIESWVIDELKRIGLDTAKSVLTLSGEELVRRTDLEEETVQFVLSILKQEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C9</accession>
    <name>A0A654E3C9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6199" checksum="695DB4E5B36A5949" modified="2020-04-22" version="1">MALWPPSLFNCDKSSLSAGAFKVSDGYCVMKIKNSHEQKFIESKVVSGRQISGMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3D0</accession>
    <name>A0A654E3D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="2 7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pdhA</name>
        <name evidence="9" type="ORF">MARINOS108_20356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="8">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="337" mass="37787" checksum="91EEA87D49D0CBC6" modified="2020-04-22" version="1">MAAKSKSKKEEFSKEQYMEWFESMQFMRRFEEKSGQLYGQQKIRGFCHLYIGQEACMAGAVSALQKGDKYITAYRDHAHPIALGSDPRTIMAELYGKATGISKGKGGSMHMFDKENGFFGGHGIVGAQVPLGAGIAFAEKYNGTDNLCMTFMGDGAVRQGAFHEALNIAMTMKLPVIFVIENNGYAMGTSVQRTSNVTELYKLGEAYDMPSSAVDAMSVEAVHHAVAEAAERARKGNGPTLLEFRTYRYKGHSMSDPAKYRTKEELEEYKKKDPIEQVRDVILKRKYATEADLKEIDNNIKERVQECVDFAENSEFPDPSEAYTDVYAEDNYPFIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K8</accession>
    <name>A0A654E3K8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21490" checksum="C7F387CF0FE0C2E3" modified="2020-04-22" version="1">MVNQKNIDIGGDGNKIVGGNDNSTTNNITIQPSGKLSSLFSKLKEQFEEGEKISNISNDLIRYTSDRDIIGLEEKLKLAQKQHLFEDFSWLKQEFHKKLLLYQEYAPAQEIFAFILAIVLDRYRNIIRPMLQSGSSESDVLRSISQEVTRPILDLIHQEGCDDIIGISSTEIEGMFHYLTGTCHIKWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R2</accession>
    <name>A0A654E3R2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">can</name>
        <name evidence="6" type="ORF">MARINOS108_20214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="23416" checksum="CA04382BFEC12425" modified="2020-04-22" version="1">MEQYYRSLLENNKKWVASKLQEDAAFFDKLAKGQKPPVLWIGCADSRVPANEITGTAPGEVFVHRNIANMVVHTDMNMLSVLDYAVNVLEVKHVIVCGHYGCGGVMAAMGTEEYGIIDNWIRHIKDVYRLHKKELDQITDNKTRTNRFVELNVLEQVKDLHETSIVRNAIKSGKELQVHGWVYDIANGLVKDLEYDSAENQALLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S9</accession>
    <name>A0A654E3S9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsB</name>
        <name evidence="8" type="ORF">MARINOS108_20932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="28579" checksum="56170B5324181C0C" modified="2020-04-22" version="1">MQKLEYKDLLDAGVHFGHLTRKWNPQMAPYIFMEKNGIHIIDLNKTLTCMDQAAHALQSVVRSGRKVMFVATKKQAKEVVETAAQKLGMPYVTERWLGGMLTNFATIRKSLKKMAGIDKLMKDESYLNLAKRERLMISREKEKLERVLGGIADLNRLPAALFVIDIKREHIAVAEAQKLNIPVFALVDTNSDPTQVDFPIPGNDDAWKSINLITNYITQSLEEGLAERKKDKEDQKLQEEEEAKKKVDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z4</accession>
    <name>A0A654E3Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">purA</name>
        <name evidence="11" type="ORF">MARINOS108_21002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <position position="41"/>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
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        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="409"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD20022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="47344" checksum="2C6CAA92BF8E1A71" modified="2020-04-22" version="1">MASVDILLGLQWGDEGKGKVVDYLAPKYDVVARFQGGPNAGHTLEFDGHKHVLHQIPSGIFHEGILNVIGNGVVLDPITFKREIEELAPFNLDLKRHLVISNKTQMIIPTHRMLDKAYEIAKGDKKIGSTLRGIGPTYQDKAARKGLRIGDINEPDFDERYKQLRDFHLEILERYNFEALLEEEEKQFFEAVELVREFDILSTEYLINQALVDGQSVLAEGAQGSLLDIDFGSYPFVTSSNTIAAGACTGLGVAPGRIGEVYGIFKAYCTRVGSGPFPTELHGEAGETLRKLGNEFGATTGRPRRCGWLDLPALKYTCMLNGVTQLFMMKADVLSDMDEIKVCHSYKLGDQITEELPLYLDTQNEGLLYESFKGWKDNNISAFENLPQSLDEYVKYIENQTQTPISLISLGPDRTQTLLKEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E420</accession>
    <name>A0A654E420_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="274" mass="31618" checksum="5A1B7F37AFFA02CF" modified="2020-04-22" version="1">MDVSVIIVNYNTLDLTKGAIQSVYQRTLGCSFEIIVVDNHSDEDPSDIPRAFKDVKFIQSHKNVGFAAGNNLGIEQASGDYILLLNSDTLLKNDAISLVFNYLRSNSDVAVASAKLEYPDGVIQHVCQRFPGLKYQMIELLRLQKFWSKEKRATVLLGAFFDHKTPCFADWVWGTFFMFNRELLKQFPNGKLQETFFMYQEDVEWCLHFSRLGFKIAYRPEAEVIHMMGGSNGPKNAMMKKNEEIFLKMHYSPWEIFLIRGLERMLKLSRLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E443</accession>
    <name>A0A654E443_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="510"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="627" mass="70480" checksum="F35B1EDB89086CC4" modified="2020-04-22" version="1">MTPRILFGFCFFLITAVGYSQPYNKRAVKLTEKAEEAAKSRDFEEAKTLLKKAIAADPLYPKAYRRLATIYSVYLQPDSAAYYYNLLTEMIPADQIDERLWDRIAGLNFEVGDYHKAQQAIAHVSDPNPLLAQSIAFSVKSVQEARPLEIQELPPAINAYQLQYFPVLTVDERTIIYTKRDANNPSSDEDMVVSVRINDEWIPSQSISREINSPFNEGACTISADGSTLIFTSCEGRSSFGSCDLYVTYRQGNKWTKPENLGSGINSRYWDSQPSLSADGRVLYFASNRPGGVGKRDIWSSQLTETGWSEPVNLGKPINTPFDETTPFIHVNNDLLFFSTQGYPGLGGFDLFFSEKTNGQWSLPTNLGYPINTVNDELSLFINASGTFGYYAIEKTESGVTSTTNIVKFKVPFDSLVKKKASYVTGRVQDGITGKPLGARMRMSNLNDTTDTYWVNSDSISGRYFLVLTEGNEYGVFIRKKDYLFEDLKFEAQSSTALRPDTLDILLHPIEAGASLTLENIYFEFNEHLLNPKSRSELNEIVEYLKLNKSLTFEIQGHTDTVGTESYNLALSEKRARTVYNYLLSKGVDESRMFSKGYGGSQPIADNSTENGRDLNRRITFRVISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E460</accession>
    <name>A0A654E460_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5029" checksum="E77FF06CD8E56613" modified="2020-04-22" version="1">MVVTATVLHGQFQRSIRASILTAPYAMNRDHAALPLVNAPHFEPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D7</accession>
    <name>A0A654E4D7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="26643" checksum="29BC34B050153EC2" modified="2020-04-22" version="1">MTYQHPTMWVSIDCLVFGYDVSEENLKLLLFQRKVEPFAGQWSLIGGFVNENEDLLAGAQRVLKTFTGLDGVFLEQLSTFGKAHRDPGGRVVSVLYWSLIKLDSIQKEVVNSHGAGWFDLEQLPDLVMDHLDMTQLGMEQLRRNATTTPIGFELLPEKFTLPQLLRLYEGIYGKSIDDRNFRKKILATDVLVRLDEKDKSGSKKGAYKYMFDERKYHELKQRGYHLDFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E2</accession>
    <name>A0A654E4E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7097" checksum="3A80988C01475278" modified="2020-04-22" version="1">MLKATLEILNLTFKKSFLEKRSIQAFFNRLKNKCLDKNTVLATLLSYAMQAVIGPAIFCSLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G0</accession>
    <name>A0A654E4G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapA</name>
        <name evidence="10" type="ORF">MARINOS108_10880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="31462" checksum="1F190390D598B61E" modified="2020-04-22" version="1">MNTEIFKGTGVALITPFNKDQSIDFDGLKAVIDHVSEGEVDYLVILGTTGEAPTITAEEKNQVTEFVIANNPRNLPIVYGLGGNSTKWVTDQLDLIKDYPLAAILSLSPYYNKPSQAGIVQHYEAIADASPFPVILYNVPARTSSNITTETTVTLSKHPNIIGTKEASGNLTQCMEIRANTDEDFLLISGDDALTLPMMSFGCVGAISVIANLQPAAFSRMVKLALAGDFKGASKLHFELLQGYELVSAEGNPVSVKSGLDAFGLIQNTVRSPLYAGSKELIRHFKMYLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K7</accession>
    <name>A0A654E4K7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="11812" checksum="44211C265F51519A" modified="2020-04-22" version="1">MKTYSLDEAQDLLIGKVGTPRRDQFEFELKLELIGDMIKTARKERHLTQEQLGELIGVRKSQISKLENNAKNVTIETILKVFEALKAKVNFKVELLNNELNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W5</accession>
    <name>A0A654E4W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="477" mass="53601" checksum="4C9C1FAF583D16B4" modified="2020-04-22" version="1">MNRRKFIQTNTLSLIGVGTLLSGMSFPVPLGDKSYTSNRPPKSKRNFVSKAVEETIGAVKKGIDNPKLAWMFENCFPNTLDTTVQYEEQGGLPDTFVITGDIPAMWLRDSTAQVWPYLPLINKDDKLRKLIAGVVRRQTKCVLIDPYANAFNKEATGGHWQSDDTEMKLELHERKWEVDSLCYTIRLAYHYWKTSGDTSVFTSEWQEAMKLVLKTFKEQQRKGGDGPYKFMRETPIQTDTMPGRGFGNPVVPVGLIASAFRPSDDATTYLFLVPSNFFAVVSLRQVAEIATEVLGDGSLARECIALADEVEAALKEYAIVEHLGYGNIYPFEVDGFGNKLFMDDANVPSLLALPYLGCVSENDPIYQNTRDFVWSKDNPFFFEGKAASGIGGPHVGMDMVWPMSIIMKALTSENDAEIAACIKTLMDTDAETGFMHESFHKDDPKKFSREWFAWANTLFGELILKTFNERPEVLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X3</accession>
    <name>A0A654E4X3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15124" checksum="CC875CB9AF40D29B" modified="2020-04-22" version="1">MILQPKQIQKVITLVTEQIGVVKGIYVFGSGAGTGYTDESDVDLALLPQKQIATEVLWELKNQLSDLVRREVDLVDLSVATTVLAMQVVSGGVRIYSSEPLASERYETLIFSMYLTLNDDRKGILEEIEKNKTIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E531</accession>
    <name>A0A654E531_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="542" mass="59136" checksum="63C2C07204ACA0C4" modified="2020-04-22" version="1">MDIKFNKNEDSNKQLISELHRKLKKVHVGGGEGKIEKLHQKGKLSARERIALLVDSMGTFLEVGAFAADGMYEEWGGCPSAGVVTGLGVVSGRQCVIVANDATVKAGAWFPMTAKKNLRAQEIAIENKLPIIYLVDSAGVFLPMQDEIFPDKEHFGRQFRNNARMSSEGIIQIAAIMGSCVAGGAYLPIMSDEAMIVDKTGSIFLAGSYLVKAAVGEDVDNETLGGATTHCEISGVTDNKYPGDKECLEAIRNIFDRIGHFEKAGFNRAEPKPPKEDPKEIYGLFPNDRNTPYDMLEIIKRLVDDSDFEQYKELYGKTILCGYGRIDGWSVGIVANQRTVVKTKKGEMQMGGVIYSDSADKAARFIMNCNQRKIPLVFLHDVNGFMVGSRSEHGGIIKDGAKMVNAVSNSVVPKFSIILGSSYGAGNYAMCGKAFDPRLIYAWPNAQIAVMSGKSAAKTLLQIKVSTMKAKGKVISDEDQQTMLDEITDSYEAKLSPYYAASQLWVDGIIDPLETRRVISTGIAAADHAKIEKPMNVGVIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E560</accession>
    <name>A0A654E560_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6296" checksum="9CC3F494BD91CD4A" modified="2020-04-22" version="1">MKCEFELYGMNSLFFLDQTANSIVESNLLIMSFFKHIMCVLSKSVAVLDKFPTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E584</accession>
    <name>A0A654E584_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 4-cresol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="469" mass="52500" checksum="77E96600ED03FC2A" modified="2020-04-22" version="1">MTSPTSYQQNITEFPVRNIEKIHLPKDLEALKTILLQAGESNRPVYPISTGHNWGLGSRMPVNDADIIDLKHLNRIIEVNRELRYARVEPGVTQQQLYDYLEVHAPELMLNVTGSDSGSSILGNIVDRGSGKSGHRAEDLRELTVMLADGQLIRTGFGELQGSQGSFYKYGLGPDLTHLFTQSNYAIVTEAVVNLRVKQPFNLYLAVLDKSGLKGFLNKMAELVAQELVGYSLEIDSQNDPKIYELFESGKDFNDKWFAWFVVTGHEEVLPAKHSVVTKALGSLVAELKAYPSSDDHSSSTPPVRVRIDRYHGQPNDHSLLATARKFGVELSGKEVNLDLYPQIPGFRCVLPVIPFTGASSDIIQYLESFSKSRGLDPAISIIALNDYSLEVFVRVYFDRSDQSAISQAGTWARDLLSELKQQGIYPYRLDIENMAPYLQELKNPYTLLQCQLKNLFDPNNIIAPGRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F0</accession>
    <name>A0A654E5F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024861619" evidence="1">
        <location>
            <begin position="27"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="56"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="589" mass="62514" checksum="F95D17330FACE4B2" modified="2020-04-22" version="1">MIMKNINSNIKYLIALLVVSMTLLTACTEEENPAISNDLRVISITYNATALEEGSEVETENPQIEMVFSHSLNTTALEEALSISNVTDYVFSYDETNSFVTIAFSSPLDYETSYTLSLPGGSYGASGEALVDDYALTFSTKAFVPSQVTLSVDKTGLLEGESASISATINQPTTVDVTVSLSFAGNAIHGMDYSLSAESLSIPKGSTSSTVTLTAINDSDIEGEESVQVTIGELINAVESGTQQINLTINDELPALIIKGVMALRWATETDGNSGKAVHLKAVEDIADLSLYSLGVANNGGGTDSIEFNLPTMSVLAGEDILIAREPSALESYFETTCYGEFEHIIQTDEMSQNGDDAIELFKGTAVIETYGDADVDGTDQSWEYAGSWAYKLGGNWTTGLVNCSEGSSSTLESDCIYPLCDNPLILKGVLAISWDGSGTNGGKAVHLLANRDIADLGVYGVGVANNGGGTDGLEYSLTSMSVSEGDHILLAREVNTLSTYFGTCFSGFNHVFETDAMNQNGDDAIELFEGSTIIEVFGDSDVDGTGQPWEYAGSWAYKVGSKWTHGGVDCAATSTTTQNSACPYTFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5H3</accession>
    <name>A0A654E5H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="PTHR13572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024909995" evidence="6">
        <location>
            <begin position="22"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="412"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="546"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="898" mass="97564" checksum="800716C73FD7C61F" modified="2020-04-22" version="1">MQTKIFTSLWLLLFLSVVSFSQPVQVTKSYGKPVFMHYMPWFDTPQYGGGWGYHWTMANKNPDVIVDGSTGKRQIASHYYPMIGPYDCQDPDVIEYHLLLMKYAGIDGVLVDWYGSQGTNGDVGSLLTNSNALIDQTDEAGMKFALILEDRFSGSISQAQGNIAYARDNYFNRNNYYRHGAGNDPLVGVFGPITFQNPGDWTTILSAANEDVEFLPLWYEAGDGGSNSDGEYVWIYEENDDYYSRMQTYYQNRAGSMKTVMGVAYPGFHDFYAEGGAGSSYFHIPHNGTGTLSQTLGLVNQYGSNIDILQLATWNDFGEGTIFEPTFEFGFSFLTTLQQFLGVSYGEYELQQIYRLYNLRKQHAGNGSIQSQLNQAYDHFVALRVNDAVSVLNAVDGGTPPPPSCDVVNIPGTLQAEGYCGMSGIQLENTTDAGGGQNVGWIDAGDWLTYQVSVPTSGSYVVNYRVASGNGGGGIRLERAGGGQTFGTIGVPSTGGWQNWTTISHTVQLTAGQQEIAIVATSGGYNINWISLAADGGGGGPNPVWGTVQAEAWSAMNGVLTETTSDTGGGENVGWIDAGDWMEYLVQVPTTGSYNIEYRVASAPGGGSVSLAQNGANLSTTNIPNTGSWQTWTTVSTTVSLTAGVQTIRLTAASGGWNINWWSVSSVGGGGGNPTGAVYKIRNVWQNTFLADGGDRVTYSTSASGAAYEWELVDTGGNKELKNVATGEYMHVQNITGYVQCTAITPGWGSAQWVIEDAGNGESRIKNVWQSNDYIHVENLQGHAQYGTIYPAWASAKWVLEPVSGARVLSEFFIEQNEIKTVLDIYPNPVTDKLTIDFSGSIDTETVWALYDLSGSLIMKRRMTAPRMEIVRGDLKSGVYMLRISTENGVLSRKVIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5P9</accession>
    <name>A0A654E5P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_60107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041286">
        <property type="entry name" value="MBG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043772">
        <property type="entry name" value="MBG_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18676">
        <property type="entry name" value="MBG_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18887">
        <property type="entry name" value="MBG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1877"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="1958"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2121"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2202"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2283"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_2" evidence="1">
        <location>
            <begin position="2364"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="domain" description="MBG_3" evidence="2">
        <location>
            <begin position="2445"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="2525"/>
            <end position="2591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2592" mass="277041" checksum="B25CB3910B5CBDE1" modified="2020-04-22" version="1">MGLGNFLDSVTTFTVTNRKFICPMKKFLTILILTSAVATHAQNVTIPDANFKAAILAHNPTIDTNGDNQIQVSEAEAFTGELSVFNKSIADLTGIEAFVNLTKLNCGANQLTALDVTANTALTRLFCYNNQLTTLDVTQNLLLDTLNTFNNQLSTIDVSQNVALKYVHFGSNNISSIDLSHLTGSLKVLGYGGNPLSSSFDFTSFSELTHLYCNDSELTTLDVSGLTNLQYLFCQNNNLTSLNAKNGTGSIIYLYGLNNPALTCIQVDDPAMNGVTLYVDAGVSFDDNCADPIVGIPDANLKEALLTYTPDIDTNDDGEIRQSEALAYTGALDLSGLSITTALGIEAFENATSLNLSGNAIKVLTLSENAALTTVNVANNDLLILSVANGNNTNFVSFDATGNDNLTCITVDDADYSTSNWTDIPAGAGFDVNCVLNIPNTNFKNALLAHNPVIDTNDDDEIQVSEATSFSGALELSYKSITNLAGLEGFGKISTLSINGNTISELDLSLNPFISQFSAEYCGLTDLDVSQNAYLKSLYLSNNALTTLDLSNNSQLTTLYVYNNDLTGLDLSQNDNLSTLYCQGNELTTLSLSAEATLLVLDYGRNPLTGNFDFAPHTSLITLGCDGGELTSLDVSMLPNLRSLNCNNNLLTELDLSANPDIFSLSAFNNQLTTFDPSGLPLLSQLNLGDNLLTALDLSNSPALQTVQLPNNSLSSLDFSNGNALNYLDCRNNELTSLNINVGKNVNYLNATGNDDLTCISVYDVDFGAAYTNVPAGVGYDHNCDDPSIDVVDPKLLEALLAYEPAIDLNANQLIETSEAAVFTGALDLSSLGIRNAAGLEAFSSIDALILDDNDFLRLDLSGNSSLESLSAQNVGLTILKLNNGNNENFTTLSLAGNPDLLCINVDDPTYAENNWVGIPEGVGFSTDCAVNFEDETFKNHAIFKGYDLNDDDEIQLSEAEAVTGKLTDGYSHSSIGGIEAFQNITELDINSTYPLFTVDLTANHNLIKIYAASGYLSSLDLSMNPNLTHIDLDNARMTFLDIRNGHNDKITVFEARNIGYIDHNLTCINVDDVDHFYDNFSDMVDEEVFFDTNCDDPLVVIPDANFKSALLSMIEDNGDGEVRMSEAEAFEGTIDVSGEEIASLEGIQYFINAIGLVADNNLLTAIDVRRNRALISVSAANNSLTALDVANQNNENFTVFNATGNPDLTCIKVDDPAYAEANWTNVDEGVGFARYCDPNDVVYIPDYYMHTSLYAADVNSSGDITYAEADAYTGLVTIHSNTEDITGLEAFTNISGIRYSGSLIENFDFSPHQALTEINIYGSHNVQSVDFSQNVNLEVLSLSNIELGGVDLTTYPELNRLYLRNCGIVSIDLSSSVNLENLNLSDNSLTGIDLSANTNLAYLYLYGNPLASIDLSANELLVEVDLSGAEITTLEVSHLSLLEDLRLEGAKKLTSLDVSQNELLYLLYASANGLEGGDPTPEDYGSLTQVLLPKGGELSDVTLEFHLLESIDLSEMTNSNLDVYLRGNKLNSVNLTGVSGSDFNLDLSLNDLDSIDLSGIVGVDAVVRLDENPLKKATLGSVYEVSLVDNPDLYCALVDDVAYAEANYFYDEQLTFTAVACENFEAEILSFDLPFQEGDEVIDGESETIMISVEDGTDVTSLEPTIEVPQGATVSPLGSQNFTDPVVYTVTSESGFFTKSYTVSVTVKSLQSITFESIPDKIYGDEAFDISVFASSGLPVDLSFVTGEDLISLSENEISILGTGLVTLQADQAGDSEYAAAVSVQRSFEISPAVLTVIAADAEITYGEAIPSLTYTISGFVNGEDETALSDTPGISTPATAESGAGNYAIELSEGTADNYTFLLEEAVLTIGKADLIISALDHEMKYGETVGNLAYEIAGFITGEDETDLTTLPILTTGASSASAVGTYTINVSGAASDNYNFTYEQAVLTIQKALLTVTADDQSVLYGGDLPELTYEITGFANNQDESVFTSQVIINTVATSTSPVGDYDILVSGAEATNYAFEFVSGTLTIEKLDQVISFAALPDVVYGAEPIVLSSTSTSGNDVEFTLVSGPVVKNGNLLTITGAGSVVIEATVDADDIYHAASTVSRTFDITQATLTVTADNETMTYGESLPELSYEIAGFVYNEDVTALASVPEITTEATTMSPVGEYLITVANGAAANYVFVYEAGILEVNPAQLTISADDQSLIYGEAIPELTYTISGFVHSEDATVLDVLPVMATTVEETSGAGTYEITGSGALSGNYTFEYEAGSLTISKANLQISADDQSLIYGEAIPSLTYTISGFVHGEDATVLDALPVMATTAEETSGAGIYEITGSGALSGNYTFEYEAGNLTIGKANLQISAHNQSITYGDPIPPLTYTITGFVHGDDESDLEISPVLTTIATSSSDAGAYTIKVDGAASSDYEISYEHAVLTVGKAEALITLSELEVGYTGSPQSPVVTTTPEGLNYIIEFAAGSEPSEAGAYDFKVVIDEANYKGNAEGVFTISRPLSALNDVQVEVYPNPVSERLFIKGLDQEVNITIMALDGRMVHQEISKDTVEVSHLPGGVYMLVIQTLNRKVLRRIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6B8</accession>
    <name>A0A654E6B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="20572" checksum="06DA688FC004285A" modified="2020-04-22" version="1">MLRFFKRKYSDTDIVMFNFLRKNRLFESLTDDELAYFLPYLYMRKYHENEVVFFTGDPSQAVYIVKRGIVSLNLDIKEGFERLLTLRSGKLFGDNAVLKGTKRIYTAIVLTNECEIYVIPKANLMEVMNNHTEVKAKIMSAFAEMYNEYMNNLFKTYKASLGFFDLGTVYSDMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6U4</accession>
    <name>A0A654E6U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13967" checksum="BD75C223E8E15A8B" modified="2020-04-22" version="1">MLLIALGLVHVIFPKYFNWKAELKFLSLINRQVMMVHTFFIALTVILMGLLCLTSANELAQTSLGKKVSLGFGIFWSCRLLIQLFGYSSQLWKGKKFETLVHIVFTCTWIYLSVVFLAAGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E732</accession>
    <name>A0A654E732_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="253"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="613" mass="69260" checksum="11DBD5CE21A04852" modified="2020-04-22" version="1">MNTRAIIIQGFILLVALIFSIRLFSIQVIDDEYKLAAENNIVQKIVDYPFRGLMYDRFGELMVYNTPVYDLMIVPKEVNLSDSSDLIKLLEIDHQTFVSRYQKARKYSSILASKFMEQIPNDFFAKIQDRLVAYDGFYVLPRTVRGYQHNMLSNTLGYVGEINRSQIIRDTSNYYKSGDYIGISGVEKQYEEKLRGKRGLRYKIVNVQGVEKGKFRDGAFDTVSIPGKSIHLTINTELQEYAEKLLKGKVAGLVAIDPRTGEILAMVSTPSYDPALLSGRDLGKNFQKIREDSLTPLFNRPLQAMYPPGSMFKTLQALIAMEEGVLRPREQIYCEGNLIGDLAPIGSYDVVKAITYSSNNYFYKVFKRVIEQGEHESRFIDSRIGLEKWNGYVNQFGLGRRLGVDIPNEQAGLVPNIQYYDRYIGTNRWAFSNIYSLSIGQGELLVTPLQMANLGAILANKGYYYTPHIVKSVEGEPALKIEKNSIDIKPEYFGVVIDGMEKVIEEGSGRRAYIPDLPICGKTSTVENPHGMDHSGFMGFAPKDDPQIAIAVYVENAGWGGRAAGSTASLVIEKYIKGEISRPWVEEFVLKGDFLDEKQKKTLKEMNMAKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7X0</accession>
    <name>A0A654E7X0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ddeIM</name>
        <name evidence="9" type="ORF">MARINOS108_20788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="42902" checksum="D2E9226B91354594" modified="2020-04-22" version="1">MMSMNYIDLFAGAGGASLGLSMAGLNPVGAVEIDDWASDTYELNHPGIKVIRSDISLLSENDIKQFKGVDLIVGGPPCQGFSIAASNRRQKSDPRNQLYTQYCRTVEILKPQFFVVENVKEIMKFKLADGSLLLADFISRLEKLGYSISYGLINAKNLGVPQERIRFFMVGSKKTISPNFIESLNNPSQKVLTIDDAISDLPVPKVGIDSIEYNKSPINSYQESMRSTSKMVYNHEPMRHTARMIERFKLIPVNGNTQDVPIEHRNRRRGEVEVLSTNIYHQNHRRLDPNKPCKTITASFYSSFIHPYQHRNLTVREAARIQGFPDTYQFMGKRTTLSKKLLKKKGIFEDMHLDQFNQVGNAVSPIVAKSIGKLLLKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E932</accession>
    <name>A0A654E932_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-allo-threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ltaA</name>
        <name evidence="6" type="ORF">MARINOS108_50086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.49" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="37146" checksum="A72BCEF8723C499E" modified="2020-04-22" version="1">MMTTSSIADLRSDTITRPTPAMLEAMMSAKVGDDVLGDDPSVNELQERIAALFGMEAALFCPSGTMANQIALRISTSPQDEVICDKDAHIYLYEGGGMAYNSMLSPKLLVGDRGRLTAEQVEENINADDIHFPRTKLVGLENTMNKGGGSIYDIREIRRIRKVCDAHGLNLHMDGARFFNALAETGEDPADYGGLFDTLSISFSKGLGAPVGSVLLASKPMIKEAKRVRKAMGGGMRQAGYLAAACTYALDHHRTRLAEDHQRARAIGRGLEGQPFIGEVIPVVTNIVIAELDGISPEEYLKKLAKKGVLAVSFGKKAVRFVTHLDFTDDHLEQTLSTFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9E3</accession>
    <name>A0A654E9E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="14352" checksum="B0300C7CB9EDA583" modified="2020-04-22" version="1">MIRPLFAFLLLSFSWACKGPQDASSSNEIITEALPGTWYKLPADASGGVIQFTADKTSLPPSRFQERIIFESDGQKVVRYTPGPDDRPKATHGSWRWITADLLVVSFGEAEDTLSVLSLNKNYLQFKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAZ9</accession>
    <name>A0A654EAZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6409" checksum="0ECEC91D14C43969" modified="2020-04-22" version="1">MGTIEDFDRILLALQEQIQNNPADRERILTDFVRTTPCPYLQNRLKASGLTSSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDE8</accession>
    <name>A0A654EDE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024993177" evidence="5">
        <location>
            <begin position="22"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="267"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="526" mass="58658" checksum="987D6480050B305C" modified="2020-04-22" version="1">MNKLMKRVSLMVLGLVFFAPACTDLEEELYSDVTADNFFTSDEEFVAALGQAYSSLLGIGNHSNLWSINEIASDELVITTKGGDWYDGGILLQLHQHEYTADNGFFNNTWGFCYSGVNTCNRLIYQFEQLGTEEADAFIAELRAVRALWYYWLLDAFGNVPLVTDFTDTETAGNSTRQQVFNFVESELNEIIPLLSEAKDASTYGRINKWGALAIRAKLYLNAEVYTGTARWADAEADADAIINSGLYSLESNYAANFQTDNAGSQENIFVVPYDQVFAQGFNWHQMTLHYGSQNTFNLQDQPWNGYATVEEFYNSYVDPAKNPGPQGDVYKGLAQATSIGTVDSRLSNFIVGPQFNPDGSRTEDAGVEPTDPDGAPLTFTPQHNSIYPDGLRQAGARIGKYEIAQGATPNLSNDFVIFRLGNILLTKAEADFRQGNTADALAMVNQIRTRAGVTPFSSLDATNLLAEWGREMYAEMTRRQDLIRFGKYDDPWWEKGTSDSHYAIFPIPQVQLDANNKLKQNEGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEP3</accession>
    <name>A0A654EEP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component transcriptional regulator, LytTR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_50095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="26266" checksum="9D5D21D8AA94D4C6" modified="2020-04-22" version="1">MTKPSILVVEDEPLIADDIADTLTKNGYHVVAIVDEGVDALQAMEDHKPDLAILDVNIEGDMDGIELAPKLGIPFVFLTSYYDKATLDRAKVLRPAGYIVKPFSERDLIANVELALHKVPQQPVAAKAHPEKLFVKRDQEILSVMSDQILFAEAFDNYAYLYTESEKYIISHTLKSIEEKLVPLGFLRVHRSYLINFEQIDSISEGYVFLKGHKVQIGKSFRKEFMDRLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DST7</accession>
    <name>A0A654DST7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024949190" evidence="1">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="268" mass="29531" checksum="B2C5DC0B782E3D64" modified="2020-04-22" version="1">MRWILLFLLLTPCLLSAQDGNYALGARNGAMAGTSLTFTDGWAAFNNPGALGGLEASTAMITYQNRYNIEGFHVLGGGLVYHHSLVNTAIKYYKFGDDLFNQQVIGLVLANRIQMVSLGAGINIIQTHAEGLSTRRVAALEMGGTAEITRQIIFGAHIFNFKHGTMHPTTMKAGLSFRPKDFLMINTEVEKQLDSREKFKAGLEYAIIKNVLIRTGLNVQGNDLSNSQVRATFGFGFQPKNFLFDYAFSNENLGAIHEISLAYQLEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT27</accession>
    <name>A0A654DT27_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">tal</name>
        <name evidence="10" type="ORF">MARINOS108_10242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="23813" checksum="41EAD01CE516DA04" modified="2020-04-22" version="1">MKFFIDTANLDEIQEAYDLGVLDGVTTNPSLMAKEGITGKDNILKHYKDICNIVDDNVSAEVISTEYEAMLKEGKELAKIDDKIVVKIPMIKDGVKAIKALTDEGIRTNCTLIFSAGQAILAAKAGASYISPFIGRLDDIGFDGLTLIEQIVQIFDNYEFETEVLAASVRHNMHLIQCAEIGADVVTCPLSVITGLLKHPLTDSGLEKFLADYKKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTL5</accession>
    <name>A0A654DTL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="249" mass="29233" checksum="916DDD9CFE3263C3" modified="2020-04-22" version="1">MLNKLTRAINKKKSYKEITLKKEKQNDRITYFITEQDNSVILQLNDYQYPEFSGYFTEHYAQDISKNNTNFIKSPARNNNSRSLGIASNKNIITNYNYDEVKSLWAFLIKISSRNKLKHTLTYSLVALLVLQLVIILGNVGKVRLGDFGTYTMFALMLLFWYVNIWTYTKFYSMNNSYWEIFRLTAYYFSLVWLFSFLEVGIIDYFQGKFNVWFSLLLVFLGQVAAILISLFTTAITYFIRGGKVVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTR4</accession>
    <name>A0A654DTR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheY chemotaxis protein or a CheY-like REC (Receiver) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15713" checksum="C7A642660199442D" modified="2020-04-22" version="1">MKPKIDCILLVDDDEDCNFFHERLIKKMECADRVEASLTGNDALDFLRSSVNGQHPRPNLILLDINMPGMDGWGFLEEYNKLSEDQKAQIVVVMLTTSLNPDDRVKAESDPNVGAFANKYLDEESLLEILKANFPHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU83</accession>
    <name>A0A654DU83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MFS transporter, YQGE family, transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="439" mass="49457" checksum="9CD909C9DFCDFFDA" modified="2020-04-22" version="1">MKGLFKILEKPVREFAFFKEQPKAMRVLLSTNMIYAFVLPVIEIFVGAYIMRSSDDPKIVALYQLTVYTGIPFTFLVNGYLLRWFRISNLYSFGMLLSGISMFLMMGLETLSFTGVGAAGFLMGASFGFFWANRDYLALGTTKDQNRNYYYGLETFFYTLTAIIVPLLVGWFLGAANRNGWFGGSMSVSYQMVTVVVVILTILASVVVHRDRFKNPEQNRFLYFRFDKLWNKLMGLAGLKGMVQGYLVTAPAILIMRLVGDEGSLGLIQGVSGAFTAIMLYLIGRMTKPKHRIAILSAGLIIFTFGTLVNGLMFSSVGVMVFVLCKVLFQPLHDIAYFPIQMRVIDVVSAREKRNEFAYIFNHEFGLYLGRFFGLGLFIVLATYVSETFALKYSLIVVALLQLLSIPLAKHITKQADLYEQSEVKTEVQEEIPLAVAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT2</accession>
    <name>A0A654DUT2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">lpxK</name>
        <name evidence="14" type="ORF">MARINOS108_10852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="40173" checksum="11360D14079F4120" modified="2020-04-22" version="1">MYWWQVIVFPFALLFDLIIRLRNLLYDHGVKKTVRFDTNVVVVGNLSIGGTGKTPMIDYLVRYFQGQDKKICTLSRGYGRRTYGFRLATIADTPDTIGDEPYMYLQKYHGIVPVAVGAERDLAISELLGHVPDAHAILLDDAFQHRRVTPSVSIVLTTYENPLHRDYLLPAGRLREARRGVQRADIVVVTKCPEYMSEADQVRMRHEIQKYTSAAVYFMTVQYDPLVPVFRNGCELKRNVLGISGMANPEPFENYLHRNYAVKHTYNYRDHYRYKPADVRDILREMDEDTSLITTEKDMVKLKQFQELRDYSCFYLPIRTKFLKDESLFLSNLESKLKNYAQEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV9</accession>
    <name>A0A654DUV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VirE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014907">
        <property type="entry name" value="VirE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08800">
        <property type="entry name" value="VirE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VirE_N" evidence="1">
        <location>
            <begin position="188"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="34788" checksum="F873D8A446AFD6C4" modified="2020-04-22" version="1">MEISREAILHKTHYGLNIYAYVLRQYYQGETVLSLSGRDCKPTKNPFNADKPTLIVKVVDGCATHTDTEEAIAQGNVFDFASLHFGLSGQELNEKLNEELHLRIGHKNGFYTQEESQPQVVAPVHVKLKAPLFSFYTKPVTNINPTRDIDLVEAYSIIKGDSFATCTSTLRSIQDVKEARKYKAFNFDYVTFSGTFSQRNDKHLRKHSGLLTIDFDHVSDLSGLKAELLKDQYFETELLFVSPSGDGLKWVIPIELTKAKHQDYFKAVANYIQHTYKLEVDQSGKDISRACFLPHDPQAFINPKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV69</accession>
    <name>A0A654DV69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="26515" checksum="C53DE260B307C773" modified="2020-04-22" version="1">MKYIILRVFWLPIMLGVVSCQQVTTKELAGLWELEHLEVDAVPRSANPTFLEINTNSSFAVSRVSGDQVGMYHFDSPLIRFRSEDRSWFNSQWKIKYFKEFIILRGVEEGYRGTQLRFKRIEAIPDFAEFEERVVGRWHMYKIRKNGEVEKVSASFTLERNGNYRMEDQNGLMEKGRVIINTRHRKLIFEHDQTQWAMWFYGDELRLTNEQMALQYSLRRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVB9</accession>
    <name>A0A654DVB9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024791620" description="Peptidyl-prolyl cis-trans isomerase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="80"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="210"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="33118" checksum="3A39F3914AA47E2E" modified="2020-04-22" version="1">MTLSRLKPVLLGLSIILLAFTTSCLKSDDVFDSAAQYTKDQEIISQYIADNGLTVQTDTSGHGLKYTMVKEGTGDSPKLNDILFLNYKGTLLSNGKVFDEQDSAFLQLSPNLIGGWQVLVPYLKEGGGMTMYLPSFYGYGHYGSGDGSIPADAILIFNIELHGIFTQFEFEQYQIERYLENNDLTAMTDTVKGLKYIITKEGTGDHPVPSDKIKVDYSGRLLANDEEFEKNENIEYTLSSLIEGWEILMPYVKEGGSITMFIPSKYAYGTNSVVRNGVVKIPPNSTLIFEVTLNRIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL4</accession>
    <name>A0A654DVL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RND family efflux transporter, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="61"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="39543" checksum="CDE28895F9718194" modified="2020-04-22" version="1">MKMKNTYLTLLSLILLYGCGDSSKEEKRELIKPIKYGMVESVGGLTTRTFSGITQSGSETNLSFRTGGLITNLDVAVGQRLKKGQLLAQLDQTDALLALEQAQLDAANAKVQLETASSGFERIKQLYETNNASLSDYERAKSTLSNAQSSYEIALKRLEKQRSQLSYTTITAPMSGIVSAVKVGTNEVIRSGQTILVMSREDASDMEVQVGVPEKYISQVKQGSPTKIRIPTLSSNFDGVIAEVGYSSSGGTYPVITSLINPSDEIRPGMPVEVTFTFGDETQETQLIVPVKAVSEDESGQFVYLLDPIAEDVYEAKRATVEIGSLTDGGFIVRSGLMQDQMVAVAGLRTLYDGMKVSLINQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW76</accession>
    <name>A0A654DW76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinol:cytochrome c oxidoreductase quinone-binding subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="422" mass="48416" checksum="A73185256B7B201D" modified="2020-04-22" version="1">MAEETFEFTAKTKKNLFIFIAVGAVLALLGIFSISMGGGHHELEGEAGHAFHWTQRLYANLWINNVYFAGIALIGVLFFAIQYAAQAGWSAGIKRIPLSFGAWIPFAGVLMLVTYFVAGHDLFHWTHHDLYDPASPDYDSIIAGKGPYFFWPLHGGSVPVFFLARLVIFFAVWYMLFAKLKSLAYKEDLEGGTEKWYQLRKLSAIFIIFFAVSSSMAAWDWVLSIDTHWFSTMFGWYNFASWWVSGLALTAFIVVLLKDKGYLSIVNANHIHDLGKFIFAFSVFWTYIWFSQFLLIYYANIPEETIYYVERWKNGQYAPLFYLNLIVNFFFPFLVLMTRNAKRHSRFIKVVAPVIIIGHWLDFYLMITPGTLKGNGGFGLLELGLMFVYSGAFIYVILNQLSKAPLYAKNHPMLEESLHHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWA9</accession>
    <name>A0A654DWA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biopolymer transporter ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="82"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="23867" checksum="4033241BBA328971" modified="2020-04-22" version="1">MLLQIEPVDGLETISVLELLLNGGFMMIPILLLWIGAIYIFVERLLLIKNSSRTPADFKDRIRSMVLSGEVDGAKLLCAQTDTPVARMIEKGISRIGSPLKNIEVSIENTGKIEIYQLEKNLSMLATISGVAPMIGFLGTVTGMIQAFIAIAQEEGAVSPKLLSSGIYEAMITTAAGLFVGILAYLGYNYLVTRVQKLVHKMEYSAIDFVDLLQEPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD1</accession>
    <name>A0A654DWD1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="34797" checksum="DCA07F185B5CE223" modified="2020-04-22" version="1">MKNFPPFIMVLLILSFISCKEDEIDAVAEEEARIQAHFDSLDVDVSISESGLYAYPIRAGGIPSAGFVLSISYKIWVLGADSTTTSIRSLDTVVVKKNANAIYPIGIDEALSYMKEGEKWGFVLPSYLAYGDHAFPNVLIPAGATMAVELEVLEVRSENDILDAEVSAIADYVTDNNLRDTVTYPLNQPEMLANGMVYKRLKAGTGATPQSGQFISVTYEGRFLDGTVFDRAPNANVFEFYLGAGSVIPGFETGVQRMQLQERALIVIPSYLAYRESAVVIPHNITSEVADLEIIPSYASKVPPYTPLVFEIEVIGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI1</accession>
    <name>A0A654DWI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="17611" checksum="406A70D0EF31E80B" modified="2020-04-22" version="1">MNDSIQKLERLLVQTEAYLTSCSEEVLSQKPAPNKWSKREILGHLIDSAINNLQRFTEIQYAEKPYVIRNYRQDDLVRVNDYQHADLQELLILWKSLNRRIGIIIAAQTDATLSYEIRFADNSASDLRFLMTDYVEHMEHHILQIRRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP9</accession>
    <name>A0A654DWP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux pump membrane transporter BepE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bepE</name>
        <name evidence="6" type="ORF">MARINOS108_11469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="5">
        <location>
            <begin position="370"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117045" checksum="1F3422D780204222" modified="2020-04-22" version="1">MFSQIIHRPVFAIVISVIIVFVGSLAIKQLPISQFPQIAPTTVSIFIAYPGSSADVLVKSTLITLENSINGVQGMRYMATDATSAGEATISVIFEPGTDPNQAVIRVKTRVDQVMPLLPELVQREGVIITPIQPSMLMYVNLYSEGEDMDEKFLYNYANVKMIPEINRISGVARTQILGSRTYAMRIWLNPDRMRAYNISIDEVMEALGEQSIIGRPGRIGQSSGIAAQSLEYVLTYKGRFNKPEEYEGIIIRANAEGESIHLKDIGWAELGSEFFDIYSNLDGHPSAAIVLKQNYGSNASEVIEDVKAKLEEMRADFPPGMDYKISYDVSKFLDASIEQVTHTLRDAFVLVALVVFLFLGDWRSTLIPILAVPVSLIGAFFVIQMFGLSINLVTLFALVLAIGIVVDDAIVVVEAVHAKMEEENLSPYNAVRKVMGEISGAIIAITMVMVSVFLPISFMTGPVGTFYRQFSITMASSIVISALVALTLTPVLCAILLKNNHGQPRKKNLLNKVLDKFNSGFDRLTGKYTGLLRVIVNKRALTFVILFVFGLGILFENHILPAGFIPSEDQGTIYAIIQTPPGATLERTNQVSQKLQKICEEIEGVESVSSLAGYEIMTEGRGSNAGTCLINLKTWSEREHSVTEIMEELEEKSKGLGAIVEFFEPPAIPGFGSSGGFSMRLLDKTTDTDYQEFDKINKQFMDDLSKRPELTGLFTFFAANYPQYELVIDNELAMQKGVSIGSAMENLNILIGSTYEQGFIRFGRFFKVYVQSAPEFRRLPSDILKLFVKNDHGEMVPYSSFMKIEKKQGPNEVTRYNMYNSAAIRGLPAKGYTTAEGIQAIREVASETLPKGYDIAWEGLSYDEARRGNESLYIFIIVLAFVYLVLAAQYESFILPLAVIFSLPVGVFGSFFMLKLMGLDNDIYAQIGLIMLVGLLGKNAVLIVEFAVQKHRHGATIFEAAIEGAKVRFRPILMTSFAFIAGLIPLVIATGAGAIGNRTIGSSALGGMLLGTIFGVIIIPGLYYIFGSLADGRQMIRDEYDRPLSEVPQHKKSNENDHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ3</accession>
    <name>A0A654DWQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="59"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32535" checksum="15F9D0F6C1D034CC" modified="2020-04-22" version="1">MKILIPALLLGLFLTNCQPAKKEQAKETIADEPLFTEPLGIAPFTFRRSFPNGIPETLDTIVSIGFTSIEGGGGDMDPYEYKKLCESKGLTIPSMGTGYNTLVEDPLSVIERAKILGAEYVMCAWLPHEKGNFTLENARKTVEDFNTFGKILADSGITFCYHAHGYEFQPYEDGTLLDYIIQNTNPEYVSFEMDIFWIQFGGGDPAALLDKYGSRWKLMHVKDLRKGVQKDLTGLTDTDNDVTVGDGELDIPAILKAAKRAGIKHYFIEDESDRIITQIPKSIEYLRSLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ6</accession>
    <name>A0A654DWQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="475" mass="52081" checksum="DC9EED32FC6CBCDE" modified="2020-04-22" version="1">MKSIYKSIIAWVMMFGFFSCGDDILDINKDPNNPGTSTPQLTLPAGQVALAVTLEADYNLMGAHLAQYWTQGPTASQFSFLEQYNITTNSYNGAWSRMYASALEDLEFVRKAAIEDGTPNYAAIAMLLQAYSFQILVDLYDQIPYTEALQGKDGLLEPKFDDGEAVYDDLIVKIDAALDLIDISSTAVTPVGDDLIYGGNMRKWISFGNTLKLKIYIRQSEARPSVAQAGIQAMYDAGATFLTPGNDALVSFTPNTNNQNPLWQILNQTTFQNIVASATSIQEFINNADDRISAYYDVSPNTNTYVGLPQGTGTTSGDQFADFSAPDGNTVINADADVILISGYESLFLQAEAAERGWGTGDPKSLYDQAVMASFSFHGLDGSALVSPGGNYEYDGELSTIYYQKWLAFNGKQGFEGWNEWRRTGVPVLSPSLQGQALPNTFPLRLIWPANETSTNPNAPELEALDAPVWWDKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ4</accession>
    <name>A0A654DWZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026336">
        <property type="entry name" value="P_estr_lig_assc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04123">
        <property type="entry name" value="P_estr_lig_assc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="37"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="25266" checksum="A869B7E70FC7FD04" modified="2020-04-22" version="1">MRSDLEIKGSEHQFHLKGQSLVLSCDRSIFWEDHSALVVSDLHLGKAGHFRKHGIPVPSQIHISDLQRVNSLIEIYRPERILFLGDLFHSDQNDEWQDFMHWSNFHSDIEQILILGNHDILDPSQYGHTRVRLCEEYMHGPFEFTHETRRSKAYNISGHIHPSIRLSGLARQGVTLPCFYFGQDHALLPAFGEFTGNHPIRARAGDQVFAIGEDLLIGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB0</accession>
    <name>A0A654DXB0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="27"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="31423" checksum="6FF6418341DF0E92" modified="2020-04-22" version="1">MNTTRITALNYTTREYFKQIYKHRHIIRSLVRRDLKIKYSQSVLGWTWAFIQPLTALIIYSIFFRYVFDFQFDKYPYALYVLSGILPWHMFSQNLHQSSGVLLSEQELIRKIAFPKFILLLAKSFVSLIELGFGLVLLLTYLAIQSGITWNILLLPCIVLINLLISMIIPIWISQLSVKKRDLLHLVPYLVNFGIWLTPIFYTIENTPKLLSTIIYANPMTGITMTYRWVLFGDPFPLEALISPTLCIGVLLLPGIVLFKNFDKKIVDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI6</accession>
    <name>A0A654DXI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="23340" checksum="865EDE290AA48259" modified="2020-04-22" version="1">MKESLRTSRYPNRTSEDKELIYNILDEALFCTVAYADSQVAHQIPTGFCRLGDEVFIHGSVKSHFITKLLESDEVSLSVMLFDALVLAPIAFNHSVNYRSAVLYSKARKVHDEAQKARVLSAYTDKYIPGRMSDLPQPTSEELGVTTVLALSIDKSLAKMRSGGVGVDTSKSNVWSGIVPFQTGYGAPEVDHGNSQVETPHYLNQLITRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM5</accession>
    <name>A0A654DXM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate 3-kinase</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glxK</name>
        <name evidence="5" type="ORF">MARINOS108_11789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="39400" checksum="02B09C828A6555B8" modified="2020-04-22" version="1">MHILIAPNAFKNSLSAGEVASAIETGLITSQLKCTTECFPIADGGDGTGELIVQKCGGEMMNVMVHDPLGRKINVSFGLIENGHTAIIEMANASGIRLLKPDELNPLETSSLGTGELILAALDAGARKIILTLGGSATVDGGMGILSALGVQFLDEGNDPLTTAETLVDLAHIEINQVDQRITDCEFVLLCDVDNPLLGEEGAASVFGPQKGATPDEVLMLEESLTRLRAVALREHGLEMDVPHGGAAGGVSAGLHAFLGASLVNGIDEFIRVTSFEAAAQKASLIITGEGSLDEQTLRGKGPMGVAVRAKALGIPVIGLAGKVPLNTPVEMKKYFQVLLSIGNGPGDVESAMKQTRENLIRIGEQIGHLLSMGQGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP9</accession>
    <name>A0A654DXP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tfp pilus assembly protein PilF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="37992" checksum="399F98A72DB748A8" modified="2020-04-22" version="1">MGLFLLGCASEEVKRDRFFLQGNIALKAREYDKAVGFYTQALAVDKDFARAYNNRGVARIEDDHAYEAIQDYNMAILLDSSYYDAIFNRAYAYERVGRTEDALSDLMIVKKAFPDSAYVYFYEGLLHSRLRAYSASMGSFQKAMQLDPANQETLINMATLYYFQEQMDSAKALLNEVLLKYPNEASALNTLSQVYLKEENYQNALTTVNQALNIQPSEPYFLNNRGQIYLEMNELDLAAKDINRSILIDPSNAWAYRNKGIYFLKSGDPEQAIRLFQEVINRPEFVDEVYSFLGKAYLEQDQLAQACESWKQGIDNHEASSQRLWELNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR2</accession>
    <name>A0A654DXR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="347" mass="39189" checksum="57C63A4076365070" modified="2020-04-22" version="1">MKNLTYILTLVTIIGLNACVDPLDVKTDSFEEVLVVEGRITTELGPHLIYITKSAKYGSIFEGVITPVDRADVAIRDNEGNTTVLTFQGNGLYATPADFQAVIGKSYVLNIEIGDKIYNSTPETVESVNVLDTLYTVYNEYPYLNENDILNYKIGVDVYANYEKQENTSNFYLWDYDGTHYIKTFPELYERPTRRGPVPAPKDCCADCYKYEENTSIIISSFPLGNNETDAKLFFLSDNGYRFIDKYVMTLKRYSLSLGAYKFYELIQNQLSIDGDIFDPPPASITGNIININDIDELVVGYFYASDVALDTLTIESSMLDRIAVLPIYPDDCRVLPNTTTVKPSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU4</accession>
    <name>A0A654DXU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BNR repeat-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024801771" evidence="1">
        <location>
            <begin position="20"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="2">
        <location>
            <begin position="425"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="572" mass="63558" checksum="C0357A9EC59A6E1A" modified="2020-04-22" version="1">MHYQLSTFFLLLLASVACKNDAPIPELSVGSKEPTHGIRLAWDYSTRQQLSPAGSGYGGYARMSVLEDNSWFVVYESEGHIHGRKSWDEGETWSEDVVIASPEGGVLATVPEILQLQNSTVMVSYNMRPGAQAPTGSRFGIRIKMSQDFGVTWSVYTEVYQAGTAFENGCWEPAQIQFPNGEIQLYIANEGPYTNSAEQEITMFSSIDDGLTWSDGKTISFRSGHRDGMPVPLILNDGRVVMSIEDNGVLPPEFKPVIIESEDGSWAQAPVGGSASARKSLFEGENRIAGTKYAGAPYVQQLPGGEVLLSYQSDEFRARNQWDQSDMVVAIGDANTWSFGCKSRPFYFENPEKTCLWNSIRVINDHEVIALGSTNAFGPNIAVWMIKGVVIPAVLKVPKAIVSSDEDFPENFLAADSVFIGGRGATQARFRFSYDEQYLYLRTIVKDQEVRGTDGISLYLDPQNRSYEAPAEGVYAFRFYHNGELEWSIGDHGLWKTINDSETIIFAQTTSEGYVLETKIPWGELGDLPIMDQRIGYHVQLHEQSATATYTENLSSNKPDQPYTWSALKLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY17</accession>
    <name>A0A654DY17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032342">
        <property type="entry name" value="DUF4861"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16153">
        <property type="entry name" value="DUF4861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="403" mass="44513" checksum="12147A6BA6B85A32" modified="2020-04-22" version="1">MIYRTLFLLTCVVCLVACQKTTTLKLTSDSSVLVSGKRLVMKKTDFPDLKASYFTLKDPKGELIPVQFDDMDGDGIWDEVAFECDFEPDGVLSLELTETDDLPDFPTNTNVYLGYSAERNNQFTSVAANSRPADHVALSTPYLYQYEGPGWESELVGFRTYFDSRNGKDIFGKAKPQLCVEQIGLGENYHELQDWGMDVLKVGSSLGAGALAMFRGDSIYRLGNTETADFRIITEGPVRAVLQLKYGGWNVGGATYGLTETISIWAGKRSYESQVLLEGREGNEKLVTGIVDLKKVAKRELEVGGVQIMYTYGNQSENHDNLGMGILVKQDGLAGFSKAPEEGEGVINTYTALLNPVDDVYSFHFFAGWEVENEAFANQNGFEEALIESANELNANISVELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY32</accession>
    <name>A0A654DY32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="32398" checksum="09A9E20C8D00D882" modified="2020-04-22" version="1">MCNAWNHPPGCTCGWGGDGHLGFGHNKIVLQPSYGDTLKFLSLWTDKNSYSSYVNPNAICPVCGRRVFFYQSQVGGRVYFDELGPPWPKHPCTDSGLLPSAYKVMRVDFVPAWVGHDWCPAVIRKIKKIQSGSIISFKKLTKEGNEFLKDYFLPEGPINISDTLIFYRDVDDNFFEFIQYQLESDIMVKQLGFKEQKVLENPLIAENIELIQKGKRFKAQYRGNKHGQYHVVHLLGIEEPKVCLVESFSGKSSNKMIHLDVEKFELDVEVKYVTPNAIYFKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY48</accession>
    <name>A0A654DY48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="34229" checksum="A43ED02F6EBCBC00" modified="2020-04-22" version="1">MYSLLPAPDPKGAGSYGQVTVLNHTVQADPFFTLKFPLKPLVSQGTKAGHMHTAITLELIDLISILLILILLFLGYNLLSLKWSYKISKPYQWEEAIRQREIPANLRTLERTYRDKVRFYTFWFQVERLRKQGVPGAFAELGVYQGETANILHEMDPERKLHLFDTFEGFHEADLHSENDEEKYSTTTFSNTSLEGVKDYINGNENVEFHPGYFPESAAGLKESQYAFVNLDADLYKPTLAALEYFYPKLSPGGVIIIHDYNHNWDGIRKALDEFMPTIPETLLELPDWQGSAMILKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE5</accession>
    <name>A0A654DYE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="PTHR33359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="81" mass="9009" checksum="F98241140A461159" modified="2020-04-22" version="1">MDVMEMNLKYFGILSEITGKPDEWLESPAETVGDLLEELNEKYPAMKLVPCQVSVNQKLAERVSVLRKGDEIAILPPFSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG2</accession>
    <name>A0A654DYG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="41607" checksum="DFB5191C6F901A97" modified="2020-04-22" version="1">MYQNIDFIKIIEDAWYEYDSSRKIKTIEDISAKVSTNHVYRVRFEDEDIIIAKLSYFGRFDHFVEDHTIINALANNLHAPFENFLAKSLTKYGQLYVYRHKDSLLDAWVVFYNPIQIDQKPERKQSDSQIIILGEELAKFHKACNKVKNTLPPTFKQTENDIDHLLEILETDHGKFEHRGHVDSIKKQCALFLENCDKIGVSEMPSIPVFVDWNIGNFSINKDYRFFSRWDYDWFRMSTRVMDFYFFSRVCSTIGDRTIFSYLVDPLMEDRFITFLKAYHKVYPLTAQEIKIIKETYRFFILNYVIKDGRYFFHELYASRLQFEAHETYFPTLDKSFNEEKLLKALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI2</accession>
    <name>A0A654DYI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17345" checksum="46B8A622EDFF77BF" modified="2020-04-22" version="1">MYQKRISGFTIIELLVSMIIASIIMSLCWGVISFVQGYKSRIETKAEEITQGARVEYLLSKDFQACEAYKLSTGHLQLISEGREIDYEFGAEVMVRILKGTRDTLGVCMNVSIEENAPGVLRTCLFFGENSHCFQLYQIVSSENQMNNTIETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ8</accession>
    <name>A0A654DYJ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGBP_B_XBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040475">
        <property type="entry name" value="SGBP_B_XBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18329">
        <property type="entry name" value="SGBP_B_XBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGBP_B_XBD" evidence="1">
        <location>
            <begin position="204"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="44913" checksum="3FF2E94677BCBF71" modified="2020-04-22" version="1">MKILDKKIFTFLIPVILLGLMTVTSCEDSEGGEPVIHYVRVTNPESSDSLLVGAFLGDLVAIMGENLGGTREVWFNDLEAVVIPTYVTNKSILVNLPSRAPSEVTNDLRLVFSNGSTLSHKFVVEISEPMPVAMVSEYASVGATTVITGDFFFEPMTVTFTGGAEAVVEVVDQNTLEVTIPEGAAPGPLTIQTNFGTTETSFHYRDQRNIFLNYDDLNADGSWRPGLYVTDDHSLDGNYLKLSGTYSADAPREEGPLGDNHYESQFWGQGNGRPEGSLIPGEPENYALKFEAKIITWDASYLNICFAPWNNGGNNEIWSNDLNPRAVWGPWESAGGAVDSGGEWVTVTIPITEFKYNMNTNDSGDVVYTESANKFNMDNTGSLSFWMLGAPSADNSPFEIYIDNVRIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX8</accession>
    <name>A0A654DYX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="18480" checksum="F166F49E7DADE26E" modified="2020-04-22" version="1">MPLKRHKSLQPLSHEHHHSLLLCWKIRMGFRKQIELKRIKRYTDWYFHQHISPHFSLEEQHLFPILGMDHPSVKKALAEHRRLKRLFTDEHEFKKNLSRIEEELESHIRFEERVLFQEIQLQISKHQLELPAILHQELPYEENTSDPFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ21</accession>
    <name>A0A654DZ21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated rhomboid family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="60"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="22354" checksum="FBF67528E753FC6F" modified="2020-04-22" version="1">MIEAATGSFFCFFSLPMYRSSVIPPLRLVFLMWLSFSIQFYGYIDLGFLGILPRTVSGLIGILAAPLIHGSVSHLVSNTFPVLFLGSAVYIFYDRIATQVFFHGYFLTNVLVWVIGRPYYHIGASGLVYALASFLIFFGIFRRNFRSILISIIVLLIYGGLIYGIYPQDSFVSWESHLMGFIVGMGSAFGLSKIRKVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG1</accession>
    <name>A0A654DZG1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="36361" checksum="45D0E1D9B86262E2" modified="2020-04-22" version="1">MPAKDNFDYTRPKRFFSSHLETIYPALFRKVKKVAPATHQRVDTPDGDFLDLDWRKQGCSRLVIIQHGLEGSSDRPYMLGMAKCFFENGYDVLTWNFRGCSGEMNRTARFYHSGATEDLDSVVQAALPDYEDISLVGFSLGGNLTLKYLGEASRYPQVRRGVAISAPLDLDAGVDKLHTANGLIYEKRFLRNLKKKIREKAFLMPDQIDVDKLRQVKTLRDFDDHYTAPLHGFQDATDYYRQCSAKYFLKGIKVPTLILNSINDPLLSQESVDHELTADLPLVHLETTKHGGHVGFYQKSSQPYFWSECRALEFCQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV0</accession>
    <name>A0A654DZV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="66" mass="7696" checksum="AB3192E5C31C67E0" modified="2020-04-22" version="1">MKTVIALILWFILFSLSWPLAVFLFFFLGFFWLILLPFRIVGFTLEVVFRTVGAILTLPFRVLKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY5</accession>
    <name>A0A654DZY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="23323" checksum="EF415F497F395A8D" modified="2020-04-22" version="1">MALRIGDDAPNFQVETTEGAIDFHEWLGDSWGILYSHPADYTPVCTTELGRTAQLAPEFAKRNTKVLAVSVDDLESHQGWIKDINETQNTEVNFPIIADPDRVVANLYDMIHPNASATATVRSVFFIGADKKIKASLTYPASTGRNFAEILRVIDSLQLTANFSVATPADWIQGQDVVITPAIKTEDIPAKFPKGHTIIKPYLRMTPQPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E052</accession>
    <name>A0A654E052_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="23283" checksum="008F70DE6FFFA057" modified="2020-04-22" version="1">MTHSANITLYQPLLQSIAFKMLGCMHDAEDMVQDAFLKYLAVDPKKIENTKAYLIRSVTNNCLNHLNSLKQKKKEYLESVKLPELFEKIDFSSLDFRQELDAMLSVLHKKLGPLERGLYLLREGFDFEYDELQQIFNKKKDHCRQMVCRAKEKLARETDKFTYSFDSEKYFSAFQKACSDGNFDDLINHLNDEQKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E059</accession>
    <name>A0A654E059_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4374" checksum="9F16A1A22907ACAF" modified="2020-04-22" version="1">MVSPLRAVIPAQAGISFSQDSRFAGDIVFPSVMEPIEPQAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C7</accession>
    <name>A0A654E0C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024857853" evidence="2">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="398"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="509" mass="58878" checksum="408FC466D5C30A95" modified="2020-04-22" version="1">MSAVNRKVILWGLLCCVWSLTGFGADEAPKYHTTFIVDAVPANTPHDASIYLVTDIDGWVTDKAERKFQRSPDGTLVLHLLHSSDTLQYKITRGTWSSVEARKNGRARPNRLLISTAPEQTVHMTVESWEDISSHSYTIYMYFLIIAAIQGLLLVVAINTIRNQNKTANSILSVLLVLITISVLGRASTFDPDVFNWEPKLLFVPELILFTYGPIFYLYIHKLLVIEVKWSRIWPQFIPFLVQFALYLPYLALERQTFIYKVLDKELFPYFAITGVLALLFNSAYWIICKRILAGYSTQEHLNEKQKKYLRFLDYVLNIKAIYLGLWLIVVVIYISGRILNTDLLYISENLIDVLWLLFSLIIFALAYYAVKHPEVLREKKKYQDQKINQDEISSIKNKLIKLLETDQIYLKPELTLESMAHMIPTASHTLSRVINEQFDQHFTELINTYRVDEFIRKVEASGDSASFLEIAFSVGFNSKPTFNRAFKKIKGCTPRQYFKEVHSSDDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J8</accession>
    <name>A0A654E0J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methanogenesis regulatory protein FilR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">filR</name>
        <name evidence="3" type="ORF">MARINOS108_11358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="16517" checksum="08661672203697E9" modified="2020-04-22" version="1">MNVHEIEILLVEDSVSDAELTIRALKKHNMANKLVHLENGAEALDYLFANGAYSEREVKNVPKLILLDINMPKVGGIEVLKQIKGDERTRKIPVIMLTSSKEDPDIDKCYDLGANSYVVKPVGFESFMKAVSELGMYWMLLNQPSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L8</accession>
    <name>A0A654E0L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methylcytosine-specific restriction endonuclease McrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="168" mass="19155" checksum="2813DCFEBAA7DC65" modified="2020-04-22" version="1">MSTVLVLNADFSPLTVCSVERAFLLVYLQKADTLSQVKEKTLRSVSREYPYPSVIKIHKYVNVPYKGVILTRHNVFKRDQFSCQYCGASKDLTLDHLIPKSKGGKSSWTNLVTACKNCNARKGDYRPEDVGLKLSSMPVRPSYVMFLRSTTKSLREDWIPYLERKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P4</accession>
    <name>A0A654E0P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="36979" checksum="B9AE4000FECEC01F" modified="2020-04-22" version="1">MSDRRIALSIVIPVYNEEESLPELFEWICRVVDKENYDTEVLFVDDGSGDTSWQVICELNKKDPRAKGIKFNRNYGKSAALQTGFEAAVGEVVITMDADLQDSPDEIPALVKMITEDNFQLVSGWKKKRHDPIGKTIPSKFFNAITRMVSGIKLHDFNCGLKAYHRDVVKNIEVYGEMHRYIPLIAKWNGFYRIGEKEVHHRERKYGQTKFGLERFVHGFLDLISVTFVSRFRKNPMHFFGALGTLSFLFGLGVTAYVIGDKMYRIYHHLDVRDVVDQPLFFLALVALVIGTQLFLAGFLAEMIIQVNHKKGDYLITERTGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q8</accession>
    <name>A0A654E0Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="18988" checksum="DBDC7FDA9E4B2E08" modified="2020-04-22" version="1">MQQIKFGMKLNSLHLKLDEIDRKILEILQSNAKITNAQLSKDIGLSPAPTLERVKKLENSGIIKSYHAKLDTERIGLGVHTFVQVTLKGHNKKNIDIFLAEINQIPEVIECHHITGSGDFILKVISKDITSYQRLMLEKVSEIDVVDSLQSMVILSTFKDSKVMPVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S7</accession>
    <name>A0A654E0S7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="7">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">purC</name>
        <name evidence="9" type="ORF">MARINOS108_11438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="35933" checksum="579605B94F79FE9E" modified="2020-04-22" version="1">MSQGIKYTQFNFPGQTDKYVGKVRDVYTVQDKLVMVASDRISAFDVVLPQPIPFKGQVLNQIAGIMLEKTKDIVPNWVISVPDPNVTIGRKCDPFPVEMVIRGYLTGHAWREYRDGKRSLCGVPLPEGLKEHDRLPEPIITPTTKAHEGHDEDISREEIIKQGLISEADYAQLEAYTYKLFARGTELASEQGLILVDTKYEFGKYNGEIILIDEVHTPDSSRYFYLKGYGARQSKGEEQKQLSKEFVRQWLISHGFQGKEGQEIPEMTKEFVDSVSQRYIELFEQITGRYFVKDTVENIIKRIDTNVNNTLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U0</accession>
    <name>A0A654E0U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="22452" checksum="AD03D6B229A3A23A" modified="2020-04-22" version="1">MRSRLVGFIFVLLLSFHMLAQESYFGWKVGYNKTALKGENSGNVSLSPRNTFSSAFVLSTQMRSLPIGFSLEPGYILKGTQIDHDTLDYKFHYLNMPVLLDVYPVKRLKLSLGVEIARLLSAKNLANDSTRQNIISTYDKRWEVSAAIGASLSVSYFMDLGIRYNTALSQISNQDAIIDRKNLFNQYTQLFILFKIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X2</accession>
    <name>A0A654E0X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fur family peroxide stress response transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15620" checksum="A2A566CEB48C0C74" modified="2020-04-22" version="1">MVESGLKATHPRIAVLHELTKDEHPSAEQLHEKIREQNPSISLGSVHRILEKLVEANLAYRVATRSGTKRYDANLEPHSHIYSVNTEEIQDYHDPKLNELIRDYFDKKQVGNFKITDIKLQINGEKADPDQQVTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E9</accession>
    <name>A0A654E1E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chorismate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="23222" checksum="9E9AEDE88E27A479" modified="2020-04-22" version="1">MSRFIETICFENGIYPMLAWHQQRVDRTFKKHFPGMPPHQLTDALPALSFEERYKVRVVYDGELTEVEFSQYTLRPLKRIQLVHDDSISYTYKYENRKALTKLFEQRGSADEILIVKKGALTDSYFANVVFWDGEAWWTPKTYLLNGVRRQQLISMGKIKEVEMTIDDLRSFEKVSLVNAMVDLGESELPVSEVRGINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G4</accession>
    <name>A0A654E1G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="69" mass="8057" checksum="9981D61316019974" modified="2020-04-22" version="1">MKRVIRNIVLLVLILVGLEQGIVFLSQYSETFKAQQHIISEEHMDPAAFFYTESEHALRAEKKLRQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L2</accession>
    <name>A0A654E1L2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="185"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="397"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="490"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="860"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1699" mass="178586" checksum="9091FA64255B97E3" modified="2020-04-22" version="1">MTVTDVDEINPVISGNSSPSIQENTTSVGTYTADESVTWSLSGTDASAFSITSGVLTFLSSPDFESPGDGGANNVYDVIVTGTDGSGNVGTLAVSVTVTDADEINPVISGNGTPSVQENTTSVGTYTADESVTWSLSGTDASAFSISSGVLTFLSAPDFENPSDGGSNNVYDVMVTGTDGSGNVGTLAVSVTVTDADEINPVISGNGTPSVQENTTSVGTYTADESVTWSLSGTDASAFSITSGVLTFVSAPDFESPTDGGSDNIYDLIVTGTDGAGNIGTLTVSVTVTDLDEIDPIVSGENLPELIEGETLVGTYTVDESVTWSLAGVDASFFTVSTGGELSFLSAPDYDSPLDAGGDNIYDVTLQGTDAAGNIGSLAVSIKVLQSDVVPPVITGDELPVIPENTLLVGQYTADEEVSWTLSGEDAGLFTVSTTGELSLNTEADFELPGDADANNIYLLTITATDGQGNFSDLSLMVTITDANDNTPEIVDPGTVSVDENSVVGTLVVGLMATDADTGSAFAWSLGTGNVDVDGDGSAPFVIDATTGELTVNDPDDLDYESGTISFSLQVIVEDGANAQGVTVFIAVNDLDETIAIGFDGLVSNDPSPELTGTVDDPEATIEVSVDGSSYTAINNIDGTWQLAGGLIADLSDGTYEVTITATGLSGGQFGSITGTLVIDGTAPLVSIESLITNITSPELSGTVDDADAAVQVTVNGTNYDAANQGDGSWVLAAGTIASLSEGTYEVTVTATDPATNEGTSTGALEIDISAPAVTVDALETLKDSPALSGTVDDPEAIVEVTVDGNTYEAIVSGTVWTVEEGTIASLAVGTYDVLATASDAAGNSAEDASTDELIIKAGAPTALAATEVDYFSFTANWKARTGVSSYRLDISSDASFVNLLSGFDNLSTTATSVVVTGLNYGSVYHYRIRAVYASGDISGNSNVITVTTPTDAGTLADSLALLSIYEATGGASWTKTNNWKASLPLREWSDISMTGTRVTLVDLSSNNLAGAFPEISEGLELLATLDLSGNLLTSLTALTSLSGLTSLDVSDNKLGFASLEPNVGISGIVYSPQKAAGERIETLEQQGTNFTIDRTVTGSSNSYKWFKENLKTKAITELTNTGSSLTIAIESFNDEGGYFVEVTNDLVPGLTIKSEPVVLKVSSLERDFAALQNIYDAMGGESWTGEQSNWPNETDFANWHGVDIQSERVVGLDLDAIDMTGELPNDILDIAGLKEVDLSGNRISKIPNMTSLSLSSLNVSGNNLEFDDLEPNVQITGINYANQRLVGAAKNDTIVHGSDFTILLEVGGSANAYQWSRTNDVGTGPVSGATSNSYTIEGISYETMGVFTLSVTNSKVPGLTLTSRKQRVLATADLTFTALDLSNELFTEGEGYALRVTAPGKPYDTIQAVRGSAAGFVFEDLILGDYLIAVRADDLVEFLPTYYPSTDLWKEAEQYILREDGMETLRMAQIPPPLPPLPDGGVVGGSIESDFADEEEEDEGARIESRRKVKRAGCSMRRFVRSGRIDQEGDFILYAYVESDDEGRFNFKDIEPGLYRFNIEYPGIPMDPESFVEFEIGADGKERNSFTLEATVTEEGIVVEKINELGFYRKYFKDLNVYPNPSDEVMHVSYAKMLAKGVVMRLVDLKGNVVLEQAVERGYDMALDLDVREIPAGVYLLNFVDTLDRKRSVVTYRVVIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q0</accession>
    <name>A0A654E1Q0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="478" mass="54481" checksum="4C40EE19BEBE22B9" modified="2020-04-22" version="1">MSNRRDFIKTGTIAMSGLAMVPPNSLFGMFQAKEWTTNRPPLAERNFTSKMVDRTISETKKKIKDPKLAWLFENCFPNTLDTTVEYAEKDGKPDTFVITGDIHAMWLRDSTAQVWPYLSLARKDKHLQNLLRGVIHRQTQCVLLDPYANAFNKTTEDEVHWMSDDTDMKAGLHERKWEIDSLAYTVRLAYHYWKVTGDDSAFDGDWQQAAKLIVKTFKEQQRKAGVGPYRFLRKSERQLDTLSNEGLGRPLKPVGLINSSFRPSDDATTYGFLIPSNLFAVVSLRQIAEINDHIKGAASFAQECRALADEVEGAIKEYGVVNHPKYGKVYAFEVDGFGNHTFMDDANVPSLLALPYLGLIEKDDAIYQNTRKLIWSTDNPYFFKGTAAEGIGGPHVGYDMIWPMSIIMRALTSAEDDEIRWCLRTLRDTDADTGFMHETFHKDNPEKFTRSWFAWANTLFGELVLKLVTQGREDLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q6</accession>
    <name>A0A654E1Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="10121" checksum="AF6BFFC4016D0DD5" modified="2020-04-22" version="1">MKKAFFKKLCCPLDKSDLEIKVIKEAGQEILEGLMTCTSCGRYYPIVHGIPIMSPDEYREPALETPILERWGLGKGEVTNFRLTEKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S0</accession>
    <name>A0A654E1S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threo-3-hydroxyaspartate ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thadh</name>
        <name evidence="4" type="ORF">MARINOS108_20199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.3.1.16" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030848">
        <property type="term" value="F:threo-3-hydroxyaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="34140" checksum="42338D9A592649DD" modified="2020-04-22" version="1">MESIPSLSDIKRAHQRISKIILETPVMTSNSIDEMTGCTVFFKCENFQKVGAFKMRGAANMILGFRPEERVNGFATHSSGNHAQAVALAAKLSGTKAYVVMPENSAEVKIKATKEYGAEVILCEANEKSRIKTCNEIIAKTGAIFVPPFDDYRVIAGQATVAKEFIEAEESLEVIMTPVGGGGLAAGTALAAKYLDPNIEVILGEPEKADDTYKSMKAGKIMPVKNPDTIADGLKVTVGERNFEIIQKEVKEVITVSEAEIINAMRIIWERMKIIVEPSCAVPFAALLKRKDEFAGKKVGIILTGGNVDLGNLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S8</accession>
    <name>A0A654E1S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024894659" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="215" mass="24226" checksum="F6DAF2A021AC25E8" modified="2020-04-22" version="1">MKTLITVLLLAATWVGYAQTQVTESANVGKQELLQLNFDFADDITIQTWDKNEVYVEVSVSINDGEYDHIFTLDKMVTERAITISMDKDMWKKVDRKGENCNFQTEIVYRVFLPSQLRLKANTINGNFIITPMTREVELKTISGDIDITVAREEGLDFKAKTISGEIFSDLEIDFPEGKEGLRQVVGMNVRGKVNSGGSPMELETISGNIYLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U4</accession>
    <name>A0A654E1U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="14825" checksum="800F712A4B8FDEBA" modified="2020-04-22" version="1">MSIQSQLSTLIQLAKIDGEFAGEERSLIMMLGKANGVSEAEILNLVENPQPLPPLSTMTDEDRFEYLYNIVQLMKIDSQVYLSEIKYCEELAEKLGFKKGVISKLSSKVFTDPSITSNREALKREVMKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U6</accession>
    <name>A0A654E1U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="162"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="353" mass="36922" checksum="C4391818E4BE080D" modified="2020-04-22" version="1">MISGFPDTGKIQEDFLKSHVFPSTGAVRQEVVSGPQYGVDVSVIALHGGQSLVTATDPATLIPTLGLQESAWLTVHLVASDVATAGCLPQYAQFCLNLPETFTAAEFHSYWNHISTYCDQLGVAITGGHTGRIAGQNSTISGGVTMMSTMPSEEVLLSRMARPGDSLILVKEPAIISTAILALSFPETILKKCGKEVLEAGQALFYASSAVDAAMSAISVGIHSEGVRAIHDITEGGVMGAIWEMMTAAGCGVQVDVAALPRGYAQDSICGAFGIDPLRSVGAGALLLAVAPGRVSGIINQLHQDGHQAVKIGEVTEERAGRWLAGEVPSPLTPPGVDPYWAAFLDALNRGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X2</accession>
    <name>A0A654E1X2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ORF">MARINOS108_140017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="32302" checksum="8D3CFABAC66CD5E4" modified="2020-04-22" version="1">MPLDQVEDEEQEMTFLDHLEELRWHLIRSLIAIMVFAIAAFAAKTLVFHTIILGPSRVDFWTYEALCRLSEMLKSPALCIDELPFIIQSRQMTGQFSMHVTSSFVIGIICAFPYAFWEIWRFVKPGLYPKERKAARGATFYVSLLFLMGVFFGYFIVTPISINFLSNYRLDPSIMNEFDIISYVSTVITLILACGILFQLPIVVFFLTKAGLVTPELLKTYRRHAIIVILILGAMLTPPDPFSQILIAIPLLGLYEVSIFISRRVTRRELLETTEIQKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E228</accession>
    <name>A0A654E228_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025047284" evidence="1">
        <location>
            <begin position="21"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="778" mass="86390" checksum="A31DF0C42B11DE0D" modified="2020-04-22" version="1">MKTKFLMLTILFLIVSNAYSQTQVIRGKLIDTDSKSPLIGATIRVLGSDPVLGNVTDINGEFRIDRVPLGRVNLMVTYIGYEDRVIPNVLVTAAKEVIVNVSMIESVEKLAEVVVTADRNKGEVRNEMALVSARSFSVEETQRYAGAFSDPARMVSTFAGVAGDAEGDNNIVVRGNSPKGLLWKLEGVEIPNPNHFASEGSTGGPVNALNSNMLDNSDFYSGAFAPEYGNALSGIMDIRFKKGNNQTREYTAGASTLGLEFTAEGPFKKGYNGSYIANYRYSSLQLLSDLGILDFGGIPKYQDASFNVNLPINRKHTLALFGLGGKSKIQSEEELDNGDPAYKGEFNSDLGILGLSHVYFISDKAYLKNIATLSATSLYSVDDLVDDNKEFYNAYNSDISKTTLRTVSTFNYKISAQHKVETGVIFSDLSYDATANEYNYDHQTLENVLSDQGGSQTIQAFTSWKYRVNEDWTITSGIHYLYFDLSNAHSVEPRAALKWQMTPRQSLNAGYGLHSKVESISTYLAKTSNDQGQLIQPNKNLTPSKAHHWVLGYDLTLSPQAHLKAEVYYQHLFDIPIENLPASTFSLLNASDSYINRPLVNDGTGRNYGLELTYERFFHQGLYYMGTLSLFQSLYTAMDGAERSTAYNGNYMANFIGGKEFNIGGPEKNKVFFVNAKVALLGGGRYTPLDLERSREQGHAVYHEDKPFSQKGDDVFFVNLTVGTRKNKKNTTREFKIDVQNVTNNQAVIREYYLEPTGEIERGTQLSLIPNIVYSIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E242</accession>
    <name>A0A654E242_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="32889" checksum="3DE097AE4D20B58C" modified="2020-04-22" version="1">MIHILDLEFQGIDHAIASFLIETSAGPVLIESGPYSTFPAMESALRQHGYKTSDIQHVLLTHIHFDHAGAAWAFAKSGAKIYLHPFGASHMEDPTRLYESASRIYGDQMGPLWGAMEKIPGDQLITLGHSEQLTIGDQTFTALHTPGHAQHHIAWELGEVIFTGDVAGVKIGAGPVVPPCPPPDINLEDWNQSLDILLERKAKTLYLTHYGQITQIDSHIQELRAMLTDWANWIKPKWESGMAADEMTPLFSKYTADQLSGLGVSAHGAKQYEAANPSWMSVAGLIRYWKKKNSQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E266</accession>
    <name>A0A654E266_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoaspartyl peptidase</fullName>
            <ecNumber evidence="5">3.4.19.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iaaA</name>
        <name evidence="5" type="ORF">MARINOS108_140127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.19.5" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024868587" evidence="4">
        <location>
            <begin position="29"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="35817" checksum="5E6AF74A42163726" modified="2020-04-22" version="1">MNSLVNRKLNLFLLIVVACLSGCNTTPAENTPNEPVERKIAVVIHGGAGTVSRENMDSVTEVAYRAKLDEALQAAYTILEDGGSSCDAIQAAIVMMENSPLFNAGVGAVFTATGENELDASIMRGEDLNAGAVAGVKTVKNPILAAYQVMINSPHVMLAREGAEQFAKERGLELVDPSYFSTDPRKAQLEKAIKKVEKEYGTVGAVAVDRQGNICAATSTGGMTNKKWGRIGDSPVIGAGTYANNNTCGFSGTGHGEYYIRTAAAHDVSALMEYKNLSVEEAAQTVMDKITKMDALGGMIAMDRFGNVAMPFNTSGMYRGYRKEGEMAVIKIFQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E279</accession>
    <name>A0A654E279_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="36381" checksum="6465CEEEA7F86ACE" modified="2020-04-22" version="1">MNLIVPMAGMGKRLRPHTLTTPKPLIPIAGKPIVQRLVEDIAAVTPEKIEHIGFVVGDFGPETEAQLLQIAQAVGATGHIFYQQEALGTAHAVHCAREVLQGRVTVAFSDTLFKANFTLNTEDDGIIWVKRVEDPSAYGVVNLDIEGVITEFVEKPKNPVSDLAIIGIYYFKEGEKLRDQLDYIIEHDIRASGEFQLTTALENLKKEGIRFTTGAVDEWLDCGNKKVTVQSNSRYLGFLAENIISDSAVIEGTVIIPPVYIGDGVKITSSVIGPNVSVGAGSEIRDSRIKDSLIQNHVNLKDINLVNSMIGNFVIMEAKPAEVSLGDFTEWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C2</accession>
    <name>A0A654E2C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024881729" evidence="1">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="167" mass="19305" checksum="3E64BB56D54514DF" modified="2020-04-22" version="1">MRKARNFFFFLLSILWLPACGQKTFDEKMESLYRNTVPVIQADKLKDKLTKEGVYLLDTRAPEEFGVSHIAGAHLIDFDNFKISMVREIPKDAEVVVYCSVGYRSERIGEELLAAGYQHVSNLYGGIFNWKNQGNTIINKNNLPTDSVHTYNKNWSQWLYNGIKVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2C6</accession>
    <name>A0A654E2C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27238" checksum="814B1CA5702A6539" modified="2020-04-22" version="1">MITLSLQLLLAHIIGDFLLQPASWVAHKTQKKHRSPYLYWHTLVHAMVLAVLLRFDHQYLLGFLTIVCSHLAIDLTKLSLHQRFNERILFFADQIAHVTVIMLVVNYYEPLNIPAEAVFQPKVLLLIIGVLIVTVVSSIIMRVIITKWALEEDAYEDSLPHAGQYIGMLERLFVFGFIILQQWEVIGFLLAAKSVFRFGDLSKSKDRKLTEYILIGTLLSFGLAIVTGLAYNHLISLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R8</accession>
    <name>A0A654E2R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="391"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="611" mass="68859" checksum="60FF9E60E21A8B88" modified="2020-04-22" version="1">MFTTFFFLYLASYAQNQKMADSLKLTLPGIIEDSVSLSVLKKITLSETNPDEKIKYSLMLIELSEKRKDYYHLQYGYSALGIGYRLRGDLEKSLESLFASATIAEKYDLRTNLGEVYAEISNTFLRRDNDIVNAISFNNKAIDIFRATGDTQQLALTLLNTGYNYYENKEYDSAIIYYDEAKAIFIEIKLTIGIAYSIGNKALIKRELGDYKGAEADLREAIEILKPLGDTYGISDYLIHLGKIYVDQGLIDKAIAIYNESLKMARDIGLKEQMRDAYGKLAELYEAEGNYQQAMGYLRQYFLYKDSISDASTVKKLADIRTEFEVGQKQAEVDLLTAEKKTQRVVMISIAAFAFILFILAIVIYQYYQTKSRINKELEALNQTKDKFFSIISHDLRGPVSSFFGISRMIKFLVQSKETEQLLEIADDIDESVERLSTLLDNLLTWAMQQQGQFPNHPEKLHLADMAGELVNTLGTMAKGKKIDLSADVQSDLVLWADKNTTMTILRNLVNNALKFTPEGGQVTISAQRDKQMVKTGVSDTGVGIPKEKMDSLFRLQDKKSTYGTSGEKGLGLGLQLVHEFIEMNGGSIEVESETGKGTTFMVSLPLFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U1</accession>
    <name>A0A654E2U1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">fumC</name>
        <name evidence="5" type="ORF">MARINOS108_140055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="410"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="326"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="467" mass="50659" checksum="D760F1E2D6C84581" modified="2020-04-22" version="1">MEIRIEHDTMGEVQVPADKYWGAQTQRSRENFKIGGANMLMPLEIIQAFAILKKSAAQANLELGVLPKEKSDLIGKVCDEILTGQLDDQFPLVIWQTGSGTQSNMNCNEVIANRAHVLNGGKLSDEKKFIHPNDDVNKSQSSNDTFPTAMHIASYKIVVEHTVPRVKKLRDTLKAKSDAFQHVVKIGRTHFMDATPLSLGQEFSGYVSQLDHSLKALNNTLEHLSELALGGTAVGTGLNTPAGYDVLVAQKIAQNAGLPFVTAENKFEALAAHDAIVETHGALKQLAVSLMKIGNDIRMLCSGPRSGIGEITIPENEPGSSIMPGKVNPTQCEALTMVCAQVLGNDVAVSAGGIYGQFELNVFKPMMVYNLLTSARLLGDACESFNDHCAIGIEPNYPVIKEKLENSLMLVTALNTHIGYENAAKIAKKAHKEGSTLREAAIQLGLLTSEQFDEWVKPEDMIGSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U3</accession>
    <name>A0A654E2U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="200"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="384" mass="45003" checksum="8558845B1B846C4D" modified="2020-04-22" version="1">MIKGKMRLAVFHYKVIENNPSGSCMHKMISAVSKDHEIVVFANEFDRNIKDHNIEWVKVPLLKRPMVLMFLTFHIIAPIVFLIHKLKGNKRFDKVIISENNLLFGDISYVHFCHKEYLEKHFKLSEGGMLHFFYFLNHFLRALIEPLVYKRIKGFIVPSNGIKRELERVYPFTKNKIKVIYNTVDIEKVRKRLNAKVIEKKWQTKNNRVELCFIALGHFQRKGLDIILYSLQKLQEEHLMLTVVGGSESLIRVYKEKAKSLGIEDYVKFTGFQKNVYRFLEHSHVFIFPTNYEIFPLVSLEAAAAGLPLIVTKVYGVEEFMIDGETGILIERTSESVIKALREVIKMNPIKLKQMGLLAQKEIETFSIDRFDENWRTYLNNQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W7</accession>
    <name>A0A654E2W7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein with beta-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024834342" evidence="1">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="25093" checksum="E9B05CBD7462B974" modified="2020-04-22" version="1">MRKITLIVILLTLTSMSTFAQSKLGLKFSPSVSSNRISLIDSLYDVEPDGSVFKFSMGLIYDHELTETYYFSTGLIFVPKQVAFMVTEEPDQPTANYTKKSPYESYRLNYLQIPVSLKLFTNEVQPDTRVFFQVGMAPEIKVFSEPTEEDYDLIEEFKGFDATILFGGGVEYRAGINTTLFASVTYQRGLNNVIKTETWGFQEELYIRNTLVSFDLGIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z0</accession>
    <name>A0A654E2Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="388" mass="45014" checksum="C9D293AC8C3A54A2" modified="2020-04-22" version="1">MVNYYTVLGVTEAASSSEIRAAFKRLALQYHPDKNDGSAEMEERFKEINHAYQVLSNPYQKARYDIQWQFGQPDEPYYTPPPPPPPRPAYRRAYKEPEVNWRENWVATAYAFGFTLVVATLVMTAIFIKRTYDEKKMEELLTQRRGIFQVAQNKYKLGEIESAISTINSLGVFMDGEDDMEAYKTNLMESFVFEAEHNYNQGVYEEAIYYFELIENYAPRNPLPLQEHLALAYREVNRPYKSLKKLKELLIFNYRKMETYLLMAQIYRDDIHDITEAKRYFEVASDLAIEKYKSIYGNAYPLVLSGASLPEEHYYLYTGLASAYLETGELEKAIKSTKWNISVWPDSVENYLIAAQSFEVLGDDTEACESIKKAREHGYTGTLNSPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A5</accession>
    <name>A0A654E3A5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="39113" checksum="B02AE3C06010C808" modified="2020-04-22" version="1">MEKVDYLIVGQGIAGSLLAYELEQAGRRVLVLNEEKKNTSSNKAAGIYNPITGRKLVKTWLADELFPGLEGYYLGLEQTLGAHFIYPMPIYRPFFNFEEQNDWSVKASEAEYAPFVKELRAKSMQLPGVIDPVGGLVLALCGYVNLPVMLRHLKKYFLDKGAYRAEVFQYDQMTINEREVTYKDIVAEKVIFCEGPMAVNNPYWGWLPFKLVKGEILEIDSPLPTDLILNRGVFVLPKNGHFSVGSTYDHAQLDYEPSESGIKNLKDRLGKLYQGEYAVVSESAGVRPATFDRRPLIGFHQDLPRIGIFNGFGTKGVSLVPYFARQLVNYLNGDGVIIPEVNVSRAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A7</accession>
    <name>A0A654E3A7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wzz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="220"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="358" mass="40195" checksum="F9E70081ADED2C7C" modified="2020-04-22" version="1">MKESKKIIQEDEIDLLELVRVIWSKRRFILKVTGIFVVLGLIISFASKVEYEASCKLMPESQEGTKGKLGGLGGLAGLAGIDLGLGTTGSLTPQLYPEIVKSVPFQLQLIHTPIRFEKLDSLMSSYTYFTEMDRPSLFGFITEYTIGLPGKIKGLFTAEEVAPSNPANDDLIRLTKEDWSLVETYRERISVSVDDKTGIITVTTEMPDPYAAARVTDLVVKKLTSEVTNYKVEKAQVNLEFIRERYAEAEKEYEAKQKQLARFTDRNKNITSSLVQIEYQRLQNEMNITFEVYKGLATQLEQAKIKVKEETPVFTILEPVKVPVGNSSPKRGLILIGMSLFGGIIAIIFSIFKNSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L8</accession>
    <name>A0A654E3L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025036225" description="Histidine kinase domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="458"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="662" mass="74901" checksum="8205C13C6FD53588" modified="2020-04-22" version="1">MKFSFFLLAVLIFTGTTHSQPQFDHLNTDSLKLILANAPDDTSKVNTALLLHDKYRLSDFPQAAKYAQTAYELSKKIKWDKGIGLSANNHAIALSLTGKGDEAVPLLHESIRHAGLAGDTSTVANCYMTLGNIEYDKTNYSEALPLYFNCFETYQSIDNYAGMSSALIWIGIIYQYAQEDYTQAINTYNEAMIYADMGKANLNKGYIASNLATIYYNQEQYDSAITYYQKGLEIKMKYNDSRGIANGYNNIGNCYFDMKRYPEALELYNRSLEIRKELFDSTGIATSFVNMGKTYAEMGNNQQAIALLERGREIAERIEYKEAVQQAFLRISELEESNKNYQAALDNYKRYKELSDVIFNTSREEIISDLKTKYETEKKEQQIVLQGAEIAEQKAENQRNLILIIGLAVMITLLIIVLILLRSRTRKKHDLLIKEGQIKLRETQIEAAISSQESERSRFAKDLHDGFGQMISILNLNLKSLQNENRDRHQVFEESAKVLEEMYQELKGICFNLMPQTLIKSGISAAIQEFAARVNTTGKVALETDFFGLEDRLSEVQEISLYRITQEWVNNILKYSDADRVSIQITKDQEEITLMIEDNGSGFNPEALISGKGNGWRNMNSRANLIKGELELDTTPGMKGSTLIVNAPVGAEIPEPETPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M9</accession>
    <name>A0A654E3M9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pssA</name>
        <name evidence="9" type="ORF">MARINOS108_20673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="24501" checksum="F8B140763C8519C4" modified="2020-04-22" version="1">MKKHIPNFITCLNLVTGALGCITILQGDFHLAIYFVIVSGLFDFMDGFAARILGVQSAIGKELDSLADMISFGLLPALYMVMLIRDQEPTNEYLAFSGLLIVVFSAIRLARFNIDDRQTDHFIGLPTPANTVLITSLTFLPAAFQLSILGLLIFTVVSSLLLVANLPLIALKFKGVSWAANKWKYLLMMVVIGLLAALQDAALPLIIPVYLVISIVGNLSTRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N7</accession>
    <name>A0A654E3N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate:Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="9">
        <location>
            <begin position="367"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="574" mass="63249" checksum="F024EDB3C4961684" modified="2020-04-22" version="1">MEFGLMDGLNLLGSLAFFIYGMKIMSEAIQRVAGSKMRQILNSMTSNRFKGVLTGFLITGLVQSSSATTVLVVSFVNAGLLSLVESIGVIMGANIGTTVTAWLISIVGFKVKISAYALVIIGLAFPLLFFSKDRIKSWGEVFIGFSLLFLGLAYLKDAVPDLKSNPEILAFLSQYSDLGFLSIILFVGIGTLLTVIVQSSSAAMALTLVMANNGWIPLELAAAMVLGENIGTTITANLAAIVGNVHAKRAAFAHFIFNVFGVTWIILVMGPFLGLISSYMLYQTGLSPETNPESVPIALSLFHTCFNVLNTIFLLGFVKSIAKICTRVIKPKGDDADEFRLEYIGTGLLNTAELSLEEAQKETVAFGKVIVKMSNTAKDLLSEPKEKKQKKLIKKMRKFEEITDQLEEEISKYLARVSDGSLSSATSTRVVSLLSIINDMERIGDVFFQMSKDFENKQNDKVGFTKKQKANLFEMFALVDEAIHNMVANLSSNYSHVTLDKALELELAIDSFRNKLRKEHIHQMESKKYDIQVGALYKDLFQSMEKVGDHVINVSEAITGESERSLKRQEEFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P2</accession>
    <name>A0A654E3P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025667">
        <property type="entry name" value="SprB_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13573">
        <property type="entry name" value="SprB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2036" mass="214984" checksum="B34277BAB9789682" modified="2020-04-22" version="1">MNNLSTFDSLESRTAPLTKGVPRSLAVLVLLLLTVSATFAQPPISGGDCGRNVLNFEAGYLSTTIDEFPISSQGSGTWEAWVKKANWGSGSQEFTIFSNAYAYPSEKAFYVSLHPMVGLHFRSGYTDGGYAAYPTTMQYTADSWHHLAATWSEDGSNVTIAIYVDGDSITSTQTTSKFGIEPTLYFGGSPTHAAFAPGSMAEIRIWDVARTEAEISSSMNSTLIGNETGLIGYWPLNDATESTTATNLVASGSAATLVSMTPSSAWVATYPFGVSSGAEVKSGSTIDFETQMTNESSEVKVFTITNNGATTLDFTESPISQMAGTDADQFILDLTGTAGSLAVGASTTLSVSFHPTSEGVKTAFFSLTNVESCEDPYTIYLSGIGSTLDGSVSVDANVSIYGGSDGQLTVSPSGGTAPYTYLWSNGATTATATGLSIGEHSVIVTDDVGASVMRSASITQPDELSITLTVDAHVSTVGGNDGAITASVTGGVEPYSYLWNNDETTASISSLIAGEYELTVTDANGATSSGSVIVTQPKPFEANIQVVTEVSGGGSYGELSAFGLYGEEPYTYLWSNGADSQVISNLTAGTYSVIITDDEGKEEEASIVLGEGITRLTYTGAFYESGDNTGSVIGSAKISLLGGRFSSDDLGTSEVSISLPSGLTSTLTVEENSLIAQDWTSLELKGDLSYQTWAVSTFGNGLFVVLANSYETSVMSSADGVNWVVGDLEHQDWSSVAYGNGRYVAVTTDGYASYSENGINWSSPAFLEDSDWKDVAFGNGLFVVIASYYDDYAVMVSEDGENWTVPGTLINDYWVSITYGGGQFLAVSEYGNVMVSSDGQDWLLYTDAMESSSVNGLAYGNGKYVVCSDDSGEELYGKIWSSTNGVNWTEQSISVSRDWELVTYGGGNFIVTGDGFNDGISMISSDGENWSTFDNGVYEVRTLNYGNGIFVGFGEHVDSDDDVFVSSTSSVATLTLSGNASSHQSSGNISDIVFDFTDAAFANMAASDVTNAANYPSGIGIDFLDNPSIIYSGDGFSEAASSDGSVTGSIMILLTGDNFKDDDEDDKLELDNEVYLGNIPDGLSATFSIIEQNTQGEDWVDATDESITGTWSITAYGDGTYVAIDNESTSFVYSTDGMNWTEGELDYNGWWDMTYANGLFVAVGAADDEYGYVMTSTNGIDWNYQAVEGYWEGVIYGAGLFVVVGDDEAMTSPDGENWTALGEIPNTEWYSVAYGNGKFVAVSPYGYYLMTSEDGINWSEIPDAEYGFEDVVFGNGLFVAMGEDYVQMSEDGVVWTHQSIDYGNWRSIIYGDGQFLIVGEGDNSESPSILRSRNGIDWTGVESVAGIVLKDAIYANGTFYGFTSDNDSWLIQSVESTGLAELILSGNASEHQNTNDLSDITFDFSNDAFVNTEATYVLNATGPASSGLGIDFHDNPANDNCANAAILPLYQIGVGIPTHGTTLNAEYFGGTVPCDESSQINDVWYSFNSGPWGLLILKSELGTAGFLAGALYESCGSEVYMMPFALEGGELYPACIPDVGGELYLELSPNTDYLIQAWNSPSDAGTFSIILETNLPPTVSQIDDIEMDELTELNLTVEATDDFIPLEALEYYLDDESEGLGMSIDLQTGALTWTPTENQEGVYSVTVWAIDYYDEESGQVSSDSVTFSITVNEVNLAPSIEEISDQVVEITGLSLQVVATDTDLPAQALTYSLDQTSLDMGISITEDGGLISWVPQLNAYGSSNMATVTVSDGVVSSSETFTLTVNKAEQAITFEALTDKTYGDAAFDLTATASSDLEVTYASSDETVASVSGSTVTIVGAGTATITASQAGNDNYSAALDVTQSLTIEKASQAITFEALANKTYGDAAFDLTGTGGASGNAVTFTSSDETVASISGSTVTILGVGTATITASQAGNDNFGEALDVTQSLTIEKASQAITFEALADKTYGDADFDLTATGGASGHAVTFTSSDETVASISGSTVTIVGAGTVTITASQAGNDNYSAALDVQQTLTIEKASQAITFEALADKTYGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P6</accession>
    <name>A0A654E3P6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="30044" checksum="507ED0784F86CF5A" modified="2020-04-22" version="1">MKKFLRVVGYFVAIFFILNILIQTIKETDTEERCPDGFDVINTDNDRLHTRGWNSIDQSRSFCGAYRSKGATSDRLAKKRLTMNLRGDSYLEFWSHVYANLVTDSKSDIGFLVDSLAAIGDRDKLSRLELAELIVSFVQDIPYSFVVPEDCKEIQTDGKPCAGNIPLGILSPYEFIHSLYGDCDTRAVLIYTILEELDFDPMIVVSNEYAHAMLALKAPATGDYLLHQGEKYYFWETTAKGWPLGMLPPNTGNVNYWKSVLAHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X3</accession>
    <name>A0A654E3X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="517" mass="59776" checksum="A96B8DBE52A6CA59" modified="2020-04-22" version="1">MRYLTTFLLAALVHGLYSQSPEARDVYETARHTTEPQYSFDGRYEYLVLPSSFSKDDIRKLPFTDRRILKIDLVYTTFRESSEFDQKQLDLARLDKLIEINPQIVVNKFFEWNIIGQTGCASSASCLDFFHGFVIYYEDYFTKETSLAEIDSVRSDLMALDQRIGELRKLLKIDYRRIDCEYPESAYSPEYLGEQLEKIYDCAETYKGRVFFEVELDYNGRPQEVTVSGNLFPCKERLAFALKYILKWKRGLVIGRRQYNVRAKGYVSFPIKKESVNITSFEISKNLMEKYKMLQQYAQCVAYETDTSYVDIFPKVDQKVVSKALFRNHWSPDLVIVDVTGSMYPYTADLLKWIKLSSLQKETDFVFFNDGNDLPTNQKVIGKTGGLYHVKTNDFSVAKEKMFEAMRAGGGGDLPENNFEALVYGEKVAKPGGEVVMIADNYSFPRDSQLLARHTGQLKIILCHTEKGINTQYLDLARKHGFTLHTLQTDIVDLQKEMLRIEGVSYKREPAGFVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E412</accession>
    <name>A0A654E412_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="29551" checksum="2F7824E17FCC0AFC" modified="2020-04-22" version="1">MESQSGSLDTEMVLVLGTSGMLLLTAAIAIFIYLYQRKLIKRKLEYQKIEDLLKKQELRSAYAMLAGQEKAYKHIAEELHDNLGSILVTLNMFADTLQKKTDPESQRKLAQKISEVAQIANESTRKISHSLDSGVLKHFGLAKAAQELVDAINESQTITVASHIQIGNTLDAEVSKNVYRILQELINNTLKHAQATRINIDLNQIEDNLNLIFQDNGVGFDLDKTPPQKGMGLRNLESRVERIGGHMTIDSNKNKGTTTIIDIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E455</accession>
    <name>A0A654E455_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein with beta-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024855954" evidence="1">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="26207" checksum="324BAF102D3363C8" modified="2020-04-22" version="1">MKRICGVAFLLTLTFTAFSQDNSRPKQPDLPGDLMLDYGFNFWTQKPDALPTRMWSSNSFGIYYNSRVRFNDYISFYPSVGFTFEKYGFDDNQTWLRDSNGDISLDSIGGVTLTKNKLVANYFEVPVEFRIHPLGTVGGEGWFIGLGAIGGIRVGSPHTKIKYNEGDNSIKEKLYDDFNVNRFRYGLQARFGFKTFHVYYKTYLNNVFTSSPDGTKNPQTYTLGVTFSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B1</accession>
    <name>A0A654E4B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="23978" checksum="6FEFF4BC2773307D" modified="2020-04-22" version="1">MDEHIMDFEFEEEIEALEQKILDHPNKKDLVVFYGSSSIRLWENLENDLTPLNILNLGFGGSSFSWCIYYFERLFANIEPSHMVIYVGDNDLANGIKPEKVLKKFRMLVKMVRLTFPRMPLDFITIKPSPIRTYLLPEIQLTNKLIRKELMGLDKARLINVFDSMLNERNVARPELYLEDQLHMNEKGYKIWRGVVRRYFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D2</accession>
    <name>A0A654E4D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025841">
        <property type="entry name" value="CP_ATPgrasp_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14403">
        <property type="entry name" value="CP_ATPgrasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="1">
        <location>
            <begin position="507"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="848" mass="97063" checksum="0E2DC607C686D0EE" modified="2020-04-22" version="1">MIESYLVDRMFNNEPFLDELATSENKVSSQWQKLAMYYDRLGPEKLGQYHDEVSRQLRENGVTYNIYGDPEGMNRPWTLDPVPMIFSGQDWAVIEKGLIQRAELLNHILSDIYGSRSLIKDGFIPFELIYNHQGFLRQVDKIKLDGEQQLIQYAADLARGPDGKMWVLHDRTDAPSGAGYTFENRAAMTRVFPDLIRENEVRKISTYYQTLKNTLVNLSSRNKENPRIVLLSPGPTNETYFEHAYLSSFMGFTLALGEDLTVSDGYVWLKTIKGLEKVDVIIRRVDDVFCDPLEFRSNSHLGVVGLMEAVRQKKVIVINPLGCRILENPGLMAFLPRLSRHILGEELILPSVATWWCGQDKEKKYVLDHLETLIIRKIYRSADNRSIYGGSLSKEELNQLRAQIDRSPYLYVGQELVNFSTTPSWINQKMEARNAVFRSYIVADTQSSTYSVMPGGLSRSSAQKGAFIVSNQQGGISKDTWVLGKREESKVTPVTEAGLRPELKSVLPSRTGEHLFWIGRYMERSVYTVRLMRMVLMTYNEVDEDIHIKENPVVSTLLRTLTKLTGTQPGFKDKKILRHPEEELISLVLDSSRVGSLAYSLNAFLSNGYAVRDRLSLDTWRILDSISEELSRMKKMGSDLTQIYDGLDSMVIKLMAFYGLNIDNMTREPTWHLLNVGRFIESAINNCTVLGSMLGKRFGSETDKSLMEDTLRCSESLVTYRYRYRSVMEMKGVLSLLILHEENPRSVIYQIMRIEKHLSSMPPQDQEVEEFLSPARKKLLEAVTKIRLCDIDLLATADGKKGNYTHLKTFLDEITALLSDTSDLIYQKYFSHTSNRYHMIQTSLLPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E7</accession>
    <name>A0A654E4E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_60021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="347"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="380"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD20802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="588" mass="67027" checksum="9D9002D3FE57EDB9" modified="2020-04-22" version="1">MEKEKTISGNILDLQILRRLFVFAKPYQKQFYLVVFLTIALAVLTPLRPWIIQYTIDNDVAIGNYNGLVFWVIVLIVLLVAQAIVQYFHTYMSGWLGQYIIKDIRVKLFNHLQNLRLRFFDKTPIGRLVTRSVSDIETLSEVFSTGIAGIIADILQLLVILVFMFALSWQLTLVSLALLPILLFATYVFKEKVKVSFNEVRTAVSNLNAFVQEHITGMNIVQIFNAEKRELEKFKEINREHRKANIKGVFYYATYFPVAEIIQAGGIGLIVWYGAGSVIQEQLTLGVLIAFIMYIQMFFRPIRMIADRFNTLQMGIVASNRILDLMDSKEYIEDNGSHHPEDIEGTVKFENVWFAYNDEDWVLKDINFEVQKGEALALVGATGAGKSSVINLLTRFYEINKGTIAIDETNIREFELGNLRNHIAVVLQDVFLFSDTIYNNITLRNPDITLEKVKEAAELVGAKSFIERLPGGFDYNVMERGATLSVGQRQLISFVRAMVYDPKIIVLDEATSSVDTETEELIQEAIQKLMKGRTSIVIAHRLSTIQNADKILVLDKGEIVEEGTHETLLELDGFYTQLHQMQYKEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F8</accession>
    <name>A0A654E4F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024991475" evidence="1">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="29562" checksum="2A83387D5B09608B" modified="2020-04-22" version="1">MKSFLLSVGILVLSTATYAQILKVNKGSIDSDSSGYLMGSTSVDFNLNNKSATAEQSITYTGLEADADLAFIGKQHAHILINQLNYFKSTGGPLISTGYAHFRTNFLRKKLLSYELFTQIQYDGGRKMPLRYLLGGNTRLRLASSAHSSLFVGIGVMYEKENWKMLTDETQIIYKNLLKSTNYISYKQAFNEHVNINVMAYYQGGYDGEADVFRSRISGEAVLNVKLTNLLAFNTSFSAQYEDQPIIPINKLVYSLTNGFKFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I0</accession>
    <name>A0A654E4I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025030810" evidence="5">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="192"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="619" mass="69045" checksum="8265177919A5BD6E" modified="2020-04-22" version="1">MVSRILMYVLTGTISLWAMAQEDTVYLEELPVVGDSFQRFTTGTGYRSIALTNSSSSLEEALSDENSIYFKSYGNQQLSSISFRGTSASQTSVLWHGIPANYPTLGQLDFSQWPAWLMERVAIQPGSGGALYGGGAIGGTVLIDSEMNLTESPLLEGKMSVGSFGYLFTGIRSAYSQGQWRGATKIFRSFLQNDFPYEYAGKQARQKNASVLNYGVQQQLSYEVSPNQKVTLDAQYTRNDREVQPSKVSPNLQDELQTGNVRLAAGYQLELPKGSLTSTLAFLQNDQQYNQDDRTVSNQYSALVAYWGELSEVLAVRLGGNTNFFTARSDNYVSHFVDRQTALFGSLEIKPTTWWTGTINLRRSFYQENRPFTPSFNQKFSVLNTEKNRVAINSQLAWGFRYPTLNDLHWSPGGNPDLKPEESFNLEGGVGWAHTGPAFSSSLDLTAFNTWSDNWIIWLPDGSGIWSPRNFRAVEITGMEFSAKMSGKWIGLLHEVGSAYSYTQSQNKEGTNQGKQLPYTPLHNANLSLKTSSDKGWFGKAMGDFTGKRFTTLDNTEIQSVDGYLLIDVHMGKTLAVSDGFDLEVSVAVKNVFDQPYENLINRAMPGKNYQFNLLIKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J0</accession>
    <name>A0A654E4J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="16260" checksum="33AC1EA307DA65C5" modified="2020-04-22" version="1">MDHQKCQTCDKPLVGRIDKRFCDSQCRANFHNRHKRKTERVIAAVNRQIRKNRSILFKLCPDGKATVRKERLVDLGFSFQYFSSVYQEGSLTYYFSYEYGFAPILQQSRTEKVPVQKVLIIQYQEHMKGKFDPWKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R5</accession>
    <name>A0A654E4R5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="1">ACCase subunit beta</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">accD</name>
        <name evidence="4" type="ORF">MARINOS108_20841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="279" mass="31100" checksum="71E56435A0C2A355" modified="2020-04-22" version="1">MAWFKRQDKGINTPTEKKKEAPDGLWYKTPSGNIIHMRELKNNAYVCPDDDYHVRIGSKEYFEILFDDNQFTELDAELTSGDPLKFIDTKKYPERIAATQKKTELKDAVRTAYGKMNGREITICCMDFAFIGGSMGSVVGEKIARGINHSLKKKVPFLMISKSGGARMMEAGFSLMQMAKTSARLALLSEAKIPYISLLTDPTTGGVTASYAMLGDFNIAEPGALIGFAGPRVIRETIGKDLPKGFQSAEFVKDHGFLDFIVDRRQLKSKLTSLLKIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z7</accession>
    <name>A0A654E4Z7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfoX_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="12642" checksum="E2134CCD9C2795EC" modified="2020-04-22" version="1">MAFNEETAQRIRMAMDLIHSFQYTEKKMFGGLSFLYEGKMTVGVVKDDLAVRVVADKMEKVLTEPHVRPMDFTKSAMKEFVYVSADGFDTEEQLMRWINLGIEHAKSKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E565</accession>
    <name>A0A654E565_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein MARINOS108_20966</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="236" mass="26439" checksum="7569E2A1362697A8" modified="2020-04-22" version="1">MGRAFEYRRAAKEARWDKMSKIFPKLAKAITVAVKEGGAELETNSKLRTAIQNAKSQNMPKDNIENAIKRALGNDAADYIEVTYEGKGPHGVLVFVECATDNTTRTVANVKSYFNKAGGGIVPNGSLEFMFSRKAVFEFEKPEGVELEELELELIDAGLEEIETNQEMVYLYADYTNFGSLSKALEDQNIEVKKASLQRIPTSPVEFTDEQMEEIEKMLDKIEDDDDVQAVYTNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F2</accession>
    <name>A0A654E5F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_140139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="178"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="388" mass="42612" checksum="256594578C812FB1" modified="2020-04-22" version="1">MSDRYAKRGVSATKDDVHAAIKNVDKGLFPQAFCKIVPDLLTKDEDYCAIMHADGAGTKSSLAYMYWKETGDLSVWKGIAQDAVIMNTDDLLCIGCVENILLSSTIGRNKNLIPGEVISAIINGTEEVLQMLRDQGIDIISTGGETADVGDLVRTIIVDSTVTARMKRSAVISNDGIRPGDVIVGLSSYGQASYESEYNGGMGSNGLTSARHDVFDKVYRDKYREAYDPAVDQALVFSGSKKLTDSVEGSPLNAGKLVLSPTRTYAPIVKKILTELPGKVHGMVHCSGGAQTKVLHFVKGLKIIKDNLFEIPPLFRLIQEESGTDWKEMYQVFNMGHRYEVYLPQEYAQEVIDISKSFHVDAQIVGRVEAAEQKEVLIQTPEGSYTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I4</accession>
    <name>A0A654E5I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="41803" checksum="379AAF3EA9BD99AF" modified="2020-04-22" version="1">MKIAIIINTSWNIYNFRRGLVRCFLDRGDEVIAIAPGDAYSKKLQDLGCRLIDLPMSASGMNPFTDFVLLLKLRGILKEERPDVVLTYTIKPNIYGSLAAGWLGIPCICNVSGLGTTFLWKGWVKKMATTLYSFAFRFNSWVFFQNTDDREEFGRFVRIDMSKTSLLPGSGVDVDHFKPGSPPENSIPVFLMISRLLVEKGIYDFIEAIRILRRKGRKAEFHLIGGLDEEHSRAVSRSELEEWIEEGLISYQEHIEDVRVAIAQADVVVLPSYREGTPRTLLEAGAMGKPLIATDVPGCNHVLIDGYNGFLCKVKNPNDLAAKMSLFLSLNDEEQFQMAQNARQSIVERFDERLVIKLYSDKMDEFVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5M6</accession>
    <name>A0A654E5M6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">hutU</name>
        <name evidence="13" type="ORF">MARINOS108_20038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="145"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="356"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="278"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD18042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="556" mass="61100" checksum="1CCD77B56C904DF2" modified="2020-04-22" version="1">MNYSQFLEKYAKHPHYKAPTGSQLHAKSWQTEAPLRMLLNNLDDEVAEDPAELVVYGGTGQAARNRESLEKIIKILLELENDQSLLVQSGKPVGIVRTHAEAPRVLIANSNLVPAWANWEHFEDLKSRGLMMYGQMTAGSWIYIGSQGILQGTYETFAECARQHFGGTLKHKLLVTGGLGGMGGAQPLAATMAGATFLGADVDPKRIEKRLQTRYIDKMTHSYEEARDWALEAKEKGENLSIGLVSDIGDLLANLQRDGIVPDVLTDQTSAHDPVFGYVPNGMSLAEAEALRKSDAVTYKDLSLKSMARHVRLMLDLQKQGAITFDYGNNLREFARQGGEPNAFDFKGFVPEYIRPLFCEGKGPFRWAALSGDPEDIYTTDKALMEAFPENTHLINWLTQAREKIAFQGLPCRICWLGMGEREKAGLIFNDLVKTGKVKAPIVIGRDHLDCGSVASPNRETEGMKDGSDAVSDWPLLNLLSNASGGATWVSFHHGGGVGMGYSQHAGMVVLADGSSRAEKCLKRVLYNDPAMGVFRHHDAGYEEATKVGEDFGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5N0</accession>
    <name>A0A654E5N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein MARINOS108_90157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybjQ</name>
        <name evidence="3" type="ORF">MARINOS108_90157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="106" mass="11211" checksum="0786CA26C6AA089B" modified="2020-04-22" version="1">MLTVTTPNIEGKQITEYYGLVTGEAIIGANIFKDFFAAITDVVGGRSGSYEKALREAKDIAVAEMQERAQSMGANAVIGVDLDYETVGRDSGMLMVSASGTAVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5T4</accession>
    <name>A0A654E5T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="214" mass="24984" checksum="D4A069CD47517BC4" modified="2020-04-22" version="1">MELHEIKRLIYGGESDLVEFKRKIAHPEKVIREVVAFANTKGGHLFVGVDDDRSIVGCKYAEEEDFLLQKAIRELCRPSIAFEVHTFQLTEKRGLLHYHILPGKKKPYYAFEKKQHRYGKAFVRVGDRSIQASPEIRKILKFNNQPQDTHFAYGLNEKLLFNYLNENEKVTVNQFRELTGLDYPSASHTMVQMVIANVLKIIPREQEDWYMAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6D2</accession>
    <name>A0A654E6D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ispE</name>
        <name evidence="11" type="ORF">MARINOS108_90155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD21525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="28463" checksum="CB688166008B84A0" modified="2020-04-22" version="1">MLSFPNAKINLGLHIVAKRPDGYHNIESCFYPIPWCDALEVLPSEKLTFTSSGLDIPGTQESNLCIKAYHLLKKTYDLPGVHIHLHKVIPMGAGLGGGSSDGAFTLKMLNDLFELGLDVPTLQNLAGQLGSDCPFFIENKPVIATGTGTNFKGTALNLSGRYIAIKHPQIHVSTQKAYSLVKPAAPTHSIEGILSKPIDQWKDVLQNDFEASVFAQFPEIRDVKNQLYSAGATYAAMSGSGSAVFGLFEQEISLDGFYTFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6W5</accession>
    <name>A0A654E6W5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22930" checksum="FC6896BD178705A2" modified="2020-04-22" version="1">MKISGEMVELRRLRINDLEMVRRWRTSDAIRSRMEYQGEITPEMQHNWFSTINNSVNYFFIIHVHDQAIGLIQLQNINFEDSVAESGLFIGEPSFWGSPAPFAASLPLLDFGINLMGIREISAKVSAVNQQAIDYNKHLGFTIDHSLGGGFLKMSISKSRFDKAIHNQKAFDRFKNTYTLLGFDQPGVSQGIFIRQSLSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E912</accession>
    <name>A0A654E912_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_120019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ADP/ATP translocase tlc family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004667">
        <property type="entry name" value="ADP_ATP_car_bac_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03219">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="939" mass="106157" checksum="4148A187BAD16FD6" modified="2020-04-22" version="1">MLEQSKDLIKAFLLRTFDVREGEYQRVLLMQLNIFLLIFTLLVIKPVVNAQFLSMMGVDQLPLMFLMVAISAMGVSMIYSRALGSRSLRRISNSTLLISVILLTFFGILLKLSISPALVLYVLYVIVAIFAVLSTSQFWIMANLAFDAREAKRLFSFIGAGPIAGGVAGGYMTSIMANYIEGTNLIFFGAGLLCVCIYLNNVIWTRHIPKLTRFQRKKRMKDFGDHPIWLIRQSKHLTYLALIIGIGVIVSKLIEFQFSSVAVQSFDDPDELTSFFGFWLSTFNVVSLLIQLFLTRRIVGTYGVGTSLFALPGGILLGSSLLLFAPVLWAGIFTRLWEVSVKQSVNKSATELLALPIPSGIKSQTKSFIDVFVDLAATGLAGLMLIFLINGLDLSVRAVSILTIFILIIWIWVALKVRQEYLNSFKSKLAQIDKKNVQPDYSNISVLNGLKRALETGTEQQILYVLDKVREIPDKRLFDNVSQFLVHQSPIVRARALQSIYYLEKTVDPQVLEGLLSDPDQEVRYKAFAQLLRQTKEQRINLIHNYLTHSDPTISGAALVGLAEEARNNEEMKRLLKVEQRIHEKIDYIGLSENPEEKYLYKVMILRAAGHANIPAFYPIIRSFMDDKEVRVINEAILAAGFTMNVTFIERLAEFLVPRETRKNAQLALLNYGVGILPELDRVVRNATTRAEVTHMIPGVLERIDAYASVKVLLSFLNTNDVMLRLEALRSLNALQRDFPHLRINKKDILGHVIDECNVYKNILGVFYKQRQLLPVHESAQIKEARTQLTSLLERRLDGTLERIFRLIGLRYPPDDIISAYEGIRSVNEHVRLNSVEYLDNLLEPTLKKALLPIAESAMLDVLSKDIIDHLKVTVPDEKKCLVMLLDGRDAKLKLAVFKLIEAVGSVEYKEMVRPFLNSHHEKIREQAAKILGQQAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9W8</accession>
    <name>A0A654E9W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase primary sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_90062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r1_2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="32842" checksum="EE66198EE597D1B0" modified="2020-04-22" version="1">MRQLKISKQITNRESQSLDKYLQEIGRVELITADEEVILAKKIKEGDQLALERLTKANLRFVVSVAKQYQNQGLTLGDLINEGNLGLIKAAQRFDETRGFKFISYAVWWIRQSILQALAEQSRIVRLPLNRVGSLNKISKTFSFLEQKFEREPSADEMAEVLEMTEGEVLDTMKISGRHISMDAPFANGEESSLLDVLEDVGEDTPDSSLLTDSLRREIQRALSTLTQREADVVAFYFGLNEQHALTLEEIGERFNLTRERVRQIKEKAIRRLRHASRSRSLKTFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBM7</accession>
    <name>A0A654EBM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ORF">MARINOS108_20117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="31728" checksum="902AE5D6BE158AA4" modified="2020-04-22" version="1">MLSLKVQIDQNSGFCFGVVYAIEMAEDMLEAEGHLYCLGDIVHNDEEVKRLEAKGLKIISHDDLLSLRDANVLIRAHGEPPSTYQLAIENNLTLIDASCPVVLKLQNRIKNSFDKKDKIYIYGKHGHAEVIGLLGQTNNEAVVFQSLDELDLDTLPKSITLYSQTTKSTDAFYEIKAKLEAAGITLNTHDTICRQVSNRDKELRAFAQQYDHIIFVSGTKSSNGKVLYNICKENNPRTYFISNKTELQKEWFTEHSSIGICGATSTPMWLMEDVRDELNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED98</accession>
    <name>A0A654ED98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20597</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015891">
        <property type="term" value="P:siderophore transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030148">
        <property type="entry name" value="Fiu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF68">
        <property type="entry name" value="PTHR32552:SF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024977032" evidence="6">
        <location>
            <begin position="20"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="113"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="350"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="816" mass="91266" checksum="584FC163CBF644C9" modified="2020-04-22" version="1">MKVFWMSMLAMTAVFSAFGQFTVDGKVVTEAGESLPGANVWLNQSKYATSTDGDGIFMLSKVPAGTFELSVSFVGYETYTKVLKVNENVSLEISLNENVIKGEEVFVYATRANEKTPTTFSNISNKEIEGRNMGQDLPFILQHTPSMVVTSDAGNGVGYTGIRIRGSDPTRINVTVNGVPINDSESHGTFWVNMPDMASSVNNIQIQRGVGTSTNGAAAFGASVNLQTDMPSQEAYAKVDNSFGSFNTWKHTVEMNTGLINKKWAFQGRLSQISSDGYLDRASADLKSYYLSGGYYGDKTTVKAVVFAGKEVTYQAWWGTPEARLNNDVDGMMEVIANNGLSDEQADNLLNSGRTYNYYQYDNEVDNYQQDHYQLHLSHVFNPNFNVNGALHYTYGRGYYEQYRADDDLADYALPDVVIGDSTISSTDLIRRRWLDNDFYGFTFSANYTKEKWDLSFGGAWNKYDGDHFGEIIWAQYASTSAIRDRYYDNFGRKTDFNVYLKGNYQVAPKVNLFADAQVRMLDYHTKGVDSDLRNIDTGDTYAFFNPKVGMTYLVKRGESFYASYAVGNREPVRGDFVDAAEGQIPKAETMRNLEVGYRKAAGNYSYSANYYLMDYENQLVLTGAVNDVGSSIRVNVPDSYRMGVELVGAVKVMDALTLSGNLTLSKNKIANFTEVIYDYGPAFDEYNEIQNEYTDTDISFSPNVIGGTQIGYKPLSFLEISLLSKYVSKQYLDNTSNDDRSIDAYFVNDLKMDLTFASKQVKQIGISLLVNNIFDVQYVSNGYTFGYAGGDYVVRENYYYPQAGTNFMLALSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDS8</accession>
    <name>A0A654EDS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4550" checksum="B5FF0C8B905421EB" modified="2020-04-22" version="1">MKLYTLSYKLKDNGYNKMRLVEEPFFKSNVLPPSKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE68</accession>
    <name>A0A654EE68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024870810" evidence="1">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21014" checksum="034BA2CA8656C6FE" modified="2020-04-22" version="1">MKYSFVLFLYASYLASAAQTFNAKASTSGVIKTSEGKYEGIIDINTTSNQVLCRSAEKTQIFSAQQIKEVRGTGAQGEEIYYKGHTLNGEAHLFEVLSDGKITLLFKPGIVKDEFTNSTYPPFFTVGKKKELIPLERKKDLISAFGGDSKWMEQFIKNNQLDLDHKEGVYRAFSYYNQTFEATNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEQ7</accession>
    <name>A0A654EEQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusC/RagA family TonB-linked outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_60003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024981193" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="117"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="432"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1077" mass="117763" checksum="5016716A9A11572A" modified="2020-04-22" version="1">MPKNKLILILCALWLSSLGAIAQQTISGTVKDPDGEPIIGATIMVEGTNYGTTSDVDGRFSIKAQNGSFLTFSFVGFETLRKTVNGPESIDVSLEIDLEELDEVIVTALGFKENRDNLGYANSVVNSESVSKAAESTLLNSLSGKSSGVRVSRNSGDPGAGAYIQIRGLSTITRDAQPLIVVDGVPISNDVRGNGAGRIAQQSRLNDINPNDIENITVLKGASAAALWGTQALGGVIMITTKSGKYNQDLKVTIKSSYSVDQINRKYPLQNTFGQGNDGVYNGRARDSWGDKISERAGGQDEFETSGEYFVDQDGKIWYPISDKKSQETYDDSNFDQVFQNGHFLENNISLSAGNANSTAFFSVSDLNQEGIIRNNSDYRRTSVRFNGEHMLNEKFRINANLTYAKTNSNRIRRGASSSGLYLGLLRNPTDFDISGYRGDYYAGPDAAPVSNRHRSYREPLAADATPTYNNPLWTINEQENLATVNRFINTLKLTYSPTSWIDLIGRVGIDHYSEERQEFNTPGSAAGEYRTGTFSSNLASNLIFNMDYIAKATKSIGGDFDLSLLVGFNFNHKQLKVDGSEISNFIQFTDVASPTRDIDNALPENRTVESSFGQERTVGLYSSMTFSAFDALFINGTIRAESASTFGSQADNTFIFPSVSAAWQFHQLLDVEGVSFGKLRASYGEVGVQPARYNTSNVFVSPTYSDQFGGGLNLGLYGNGGFVPSTSRGNPNLQPERKKEFELGGDLRFLKDRLSLSATYFQNTTENVLLDFPIANSRGYDRIYSNGAEIENKGVELDLGYTIIETKDFGWQANVIYTDVQNKVTDLAGVESLALGGLDAVNNRAVEGKSLGVLWGSRTLRDDAGNIVYDKNGFPEQDQLEGVIGDPNPDWQGSVSTTIRYKNFALSALLETFQGADIYAGTKSVLYDLGRWEGSAKESMSTQNLLDYNGNVIPMGTTFRGVVHDFGAGPVALTEPWYLGDGGFFGNGNDELYIEDGSWTRLRELGLSYQMSNSLLKKLGVKSAEISATGRNLFLWTKFEGNDPDTNLNGVSAARGIDYFNNPSTKSYVFTLLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSE0</accession>
    <name>A0A654DSE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusC/RagA family TonB-linked outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025047803" evidence="5">
        <location>
            <begin position="28"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="123"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="393"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112396" checksum="F0F5F453D98E333F" modified="2020-04-22" version="1">MGILQIIQFRGFFTLLMLCAAVFTASAQGRVISGTVTDGGDGSEMPGATILEKGTSNGTITDIDGKYQLTITGDDPVIIVSFVGFESKEIKVGAQSVINVSLDISLSELSEVVVIGYGVQQKRVATGSISKVDAKDIEGYKVANVLSAIDGQVSGVIAGESSGQPGSSKSVFIRGISTNGDNSPLYVVDGLTVSGIDNLNPSDIESVDVLKDAASTAIYGARAANGVIIITTKKGKDGTGVLSYEGFTSFSNPWKMPEMLNSEQYIELTREKFANSNRTAALDALGFPNAGDATANTNWMDVITDQATMINHRLTATLNNSYISLDYWDQQGVIGGDKSNYKRYAIRLNSTKKVNDYFTVGQNFYLNRTENQNLGVNNAFGTMVADAFAYDPTTDVYDADAEYGFAQSNWVQKEYINPLSRLFLADNSGHADQIQGNAYIKFEPIKGLTFQSDLGIDFSWYDYRSFTPDYNYHPSFFSVNNSISQGYGFGQRIQFENYANYTKDLGNHSLNVVLGTSYLGSEFRTAGGSTLNIPDAAKFNDQFQYIDAGQDTSDLAFGRASVDYRLLSYYGRVIYDYRDKYLFSVTLRRDGSSRFGANNRWGFFPSMSAGWVISDENFFPTSPISFLKIRSSWGVNGNDRIGDLGYSSQVVNAFSYALGVDHALNRGSALATVPNPNLKWEESVQFDVGLEIKLFNDQLSAEFDYYVKTTRDLLGNEIVPGYLGVTDFPLSNLGEIQNKGLEASVAYKQRIGGLTLNTRLNYTTFKNTVNEVPGSSTYINGWSWPVRNAAITRMSEGEPVGHFVGYKTLGIFQSEADVFSHLSSSGDVLQSDASPGDLIFADVNKDGVINTDDITSIGSPWPDHILGLSFSANYKGFDFSALFSTQIGHDIFRTYERSDITFTNYQTFWLDRWTEENHSTKYPRLVSNDPNGNQRPSDFYVEDGSFLRLRNIQIGYNIPASILEKIKLTGVRVYLSGNNLLTVTNYTGFDPEIGTNGWILDSGIDKGYYPSNKTIGAGVKITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSR9</accession>
    <name>A0A654DSR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="62"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21550" checksum="3192BB1ABB039390" modified="2020-04-22" version="1">MLEWVLELDEKIFLTLNGLGSPYLDTFMIWMSDKYLWIPLYLYLIFRLYQQEGKKLLWPLITLIVVIICTDQTTAGFMKPYFERLRPCKDPALEDLIVIIGECRGKFGFASGHAANSFGLAAFFYFKERSLFSKGLLLWAAIVSYSRVYLGVHYPADILVGMLVGVFWAYVLYATMKSFRLRAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSX1</accession>
    <name>A0A654DSX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="487" mass="56422" checksum="A3D540FF20784BD2" modified="2020-04-22" version="1">MSVGEKELYEIVVDIEHRHPVNDWVYGGIELWPLMRSSLRDSFLVNQRRLASKKKKQPSLKLNFSSFFHSFKTFRSLRKRDLMIFTSTSGHADRREDKLYDRVADPVYEFMANRFGWSATKVSNGKRVSDVEGFFPMNFLDLRLFANPVKYLRHQKRFTKYLASIEATDEIESRSGLAIKSLLIKSVCFILASEQSAKAILKRANPTLVAFVCYYHNVNFAYLNAAKSLAIPTIDIQHGKQGVYHLMYAHWGQVPNNGYRMVPDFFWNWGESSKLNIEKGRNNLQQHQPVVLGNHWLINWKKNKAERESPQYRKLLDSYSTVVLFSLQQDMEIPIPDFVLDEIQTQKDVLWLFRLHPAQKIGNAKVLKSLADLKVSNVEIHESSKLPLYQIIEHVHLHLTNWSSVCIEALNFGVKSIIVHPNGYDLYEELINTEQFFYAKDSSDLCMAMDKIAADAGQVDASDHFLMDMEVIERRASQLFLEGMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTT4</accession>
    <name>A0A654DTT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="67"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="44635" checksum="20AE14630E093927" modified="2020-04-22" version="1">MKNIITYFNRISMVVLIGLAITSCSSKNERTTEEHHEEGDNTVELTQAQFEQASIVVGTFEQRVIGSELRVNGIIDVPPQSNISITMPYGGFVKNTEMLPGSMVKKGQLLVVIENPEFIQFQQDYLESLASQEFLKAEYDRQKELYDEKVASGKSFQQAKSDYMANEARIKSMEARLKLIGFSVSKIKEGNVSASVNIYSPVTGAIREVYTNVGKFINPQDVIMDITNSDDLHVELTVYENDVPRIKEGQRIRFALANSPNEWREAEVFLIGSGVREDRSVTVHGHLKKMHSDLKPGMYIAAKIETDSNKTWAAPDESIVRFGGKHYVFVYAGERSEDGQQMHDFEMLEVQKGSSEDGFTQISLLETSLEISSLKLVTSGAFTLLAKAKNSEDEGGHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTT8</accession>
    <name>A0A654DTT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="25984" checksum="B743B2278A0BE2CA" modified="2020-04-22" version="1">MKRAIKITLITILSLLIVLIIAWLTANEPLPEGEPGPRAEALADRMLLALNDSAYQNLELISWKYPRGPHEYDWYKQKDTVEVRWGNMRVLLCTTTLDGSAFLGNEALSGSEKEKALYTAWDFFANDSFWLIAPFKVKDPGTERKVVETDRGPALLVTYTSGGVTPGDSYLWILDENDRPIAWKFWVQKIPIGGLESSWADWQQYKGVWLGTSHEVGPLEIKLEIQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU22</accession>
    <name>A0A654DU22_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="35356" checksum="C307A99BC39FACC3" modified="2020-04-22" version="1">MESIITEIRNGYAGYAGYLWQEITHPTWHNYFYWLLGVSAFFFALELLKPWRVDQAKFRKDFWLDFFYMFFNFFLFSLIIYNAASNVVVHLFNDLLGLLGITNLVAFEVMSWPIWAHLLLGFVVRDFVQWWIHRLLHASPRLWEFHKVHHSVAEMGFAAHLRYHWMENVVYRTIEYIPLALIGIGLRDFFIIHIFTLAVGHFNHSNFKLNLGPLKYIFNNPQMHIWHHAYHLPAERRLGVNFGLTLSVWDYLFGTDYIPHDGRDIQLGFPGVEEFPADFIGQNTHGFSGKVTSPGDKKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU93</accession>
    <name>A0A654DU93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025841">
        <property type="entry name" value="CP_ATPgrasp_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016450">
        <property type="entry name" value="UCP005522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14403">
        <property type="entry name" value="CP_ATPgrasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005522">
        <property type="entry name" value="UCP005522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="53070" checksum="BF3A3F4D73DFC97D" modified="2020-04-22" version="1">MIFDKYNPSEHFDEMFDDESCRPPYQQFKQALEQYSGKKLLQLQDSSDKAQMSMGMTFNVYHDNQGVEKILHLDLIPRIISAEEWSIIEEGLKQRISAINLFINDIYHEQKILKDGIVPKELVLSSRDYLKPCIGLNPPKGIWCHITGSDIVRDKSGKFYVLEDNLRCPSGVSYLLENREIIKQAFPGLFAGLGVRPVSDYSNMLLNMLQHLSDKPNPTVAVLTPGIYNSAYFEHSYLAQQMGVQLVTGQDLIVKNKNVYMQTTKGLQQVDVIYRRIDDTFLDPLTFNPDSMLGVPGIFEAYLAGNVALANAPGTGVADDKAVYAYVPRIIKYYLDQDPIIENVPTYLCSEKDDLNYVLENIEDLVVKETNAAGGYGMLIGPKADSSEHTKFRKLVKENPRNYIAQPTLSLSTVPTITPKGIAPRHVDLRPYVLYGDSIKVLPGALTRVALVEGSLVVNSSQGGGSKDTWVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUB9</accession>
    <name>A0A654DUB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="16058" checksum="89B3108B860B7568" modified="2020-04-22" version="1">MASLIDQIWQISQKPSSAAGFTIYTYGLDKPVVGYCVAYSDTQDCFGQEGLAKALAHAQTHAQVLGGWLDNGKFYFDSVRIYQTKPAAIEAAIKENQIGLFDLNGGYVPIRNQDLVLLPNYQTFLSQVNAIRAKAGLQPFPVLNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUE1</accession>
    <name>A0A654DUE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6506" checksum="BB4E306B983B89D1" modified="2020-04-22" version="1">MHDLRYHHSGIRTTLLFDQYRNEDGAFFADLTKTGITFCGILNQMATFNIKIDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUI7</accession>
    <name>A0A654DUI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="24100" checksum="D4FD19F393C66DD7" modified="2020-04-22" version="1">MFTEYEIETMVELPEVLEATQALKKDFCKNEAPYLEISDHDFFSLIMMAPTVGIALADGTVSLFEELALNKKARKLSKGGYFMKKDPVVYAMKFLLKKYDIWSDKFFNVLKVAMHVSFDMERLEKKKFDEEAEVTYPEYKKAVLNTPYILIRFIASFFLENDEEIISTNRHIGRNEYLQMLKIGEQMGLNKLPVFQMFCKTFDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV8</accession>
    <name>A0A654DUV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025833">
        <property type="entry name" value="GDYXXLXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14345">
        <property type="entry name" value="GDYXXLXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="21908" checksum="749B2524249F5C10" modified="2020-04-22" version="1">MSRSKILIPAFICVALLQLYVPGRMIWDREQVLIHGKEYLFKTAPIDPTDPFRGKYIQLNYEAATYPIAHKDDWTNGAAIYVTFSEDANGLAVIKTVSKEKPTDTPYFLKAHVDYVTYDDVLMIAYPFERFYMEESKAYEAEQEYNLATQGDTTLTYAVVHILEGSAVLEDVRINNTSIQEWVVQSRMGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV50</accession>
    <name>A0A654DV50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="199"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="33184" checksum="17C0A28CE15D3A63" modified="2020-04-22" version="1">MMFASQFPDQSTISRLRNQPSPDGQHLKWPDVLVQSRYRTYEKSVPESSFALFTLKSPGEATFSVGGKHLRICQQTLCLINPYEAFEYRIEANEAVEVQNLHLSLSTYRQLMHAMGTSPNRLLDPPAESEAPAEWPHHLYYMDPAMKGLLDQYRSLCPEDFLTGIGSLLQRLSAQNQQVTKRIPSQKRATQKELAKRVAIGRDLIFSAYNDPDLTLDRICAEVFMSKFHFIRVFKQAYGLTPHQLIRHIRILKAQEYLKTGQMTLEHIAYKVGLQEPNSLYPLLRTEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV56</accession>
    <name>A0A654DV56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="52874" checksum="F086327920C88D0F" modified="2020-04-22" version="1">MRELTDLEKSWVKSLSELPPAADQPIAGWLETVFFKEAEGRALIIQASEGFAVLFLTNELFNDETKKAAQVSQFSELISFLKYLHREGYLSISRGKTTRDKSMFFIQDAFIDPKNQNGPIVLNAKGDYTDNPHKILDTKKNTVYQGIRFDTDQFDAILSTCTGSLLVSSAIGQLIAEKKPLNKEKKTSEVNWNILSVWVSILSAFLCLFIYIHYQSTHHRRALSLVDYKQDQLGYRLDSLNGHLESLASRQNTTSRSRQATQRGIDVSRWNGDLLQAVSKRDLLSFVICKATQGKSYVDPDFHTNWNLITEKGLIRGAYHFYDASQDPIDQAEHFVTTLGELTSTDIGPILDIEPESIPTDFEVDPLQLQVDLYIFLRHVERLSGRKPIIYTDPSFGDQYLTNEKFGQYPLWVADYTDAPQPTIPKVWSDIGYKFWQKSASYDLHSDKTDLDLYNGEKAGIYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD0</accession>
    <name>A0A654DVD0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplI</name>
        <name evidence="10" type="ORF">MARINOS108_10953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="15875" checksum="9235A1A9C2AD2F18" modified="2020-04-22" version="1">MEIILKDDVKGVGYKNDIVSVKPGYGRNYLIPQGFAIIASESNKKMIAENVRQAAHKAEKIKNDAEEIASKLGDLKLEIKTKAGESGKIFGAVTALQVADALKEKGFDIDRKKISLGSIKELGEHTAVIDLHKAVHHEITISVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVE2</accession>
    <name>A0A654DVE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4084" checksum="40CFF0F9BA5F1941" modified="2020-04-22" version="1">MPSGGEKSEPGGYQQGQRHAEPAKALQAVEMEGESHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK4</accession>
    <name>A0A654DVK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="23724" checksum="D0FDDEA9714D4E5A" modified="2020-04-22" version="1">MSEQSNESGKTVGIIIIVVFALAGLVGLWYWVMYKPQQEAKEQVKLEQIAKEEAAKKAAELKTQNKIKYDQLIKDADTEMGQENWQRAKSLYTEASSLFPNEQYPKDQLAIVNQKLGELAALEARRAAGVVESVATRTGRFYIIVSSSIDDDLAMDYANKLAQEGNAVKIIEHDTGKLVYYRVSVGDYASREKAESAAVAFSNLSDEVWVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP3</accession>
    <name>A0A654DVP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type lipoprotein release transport system permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="320"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="440"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="799" mass="89917" checksum="3611F3E87B34104B" modified="2020-04-22" version="1">MLKNFLKVALRNLLKNKVYVAINIVGLGLALACCIVAYLNSKQNWDFDKSHTQIDHIYKIHNLRETQGDLIEYGRIPMPMADAIRNDLAGADRVFRFESHVFTVRDVNMDKVFNTSVCYADPGLIESFTFPVVTGDPLAYHKLDQAVVTEEYARKFYENEDPIGKVLTVFDDTGMSFNFTIAGVVEAPPQNSSVHFEILTSFENRFRMYDDNVKGNWGAFAQNTFVYFNDPNQAKTFEPLLDQYLAVQQEARPDFTIARFVLSPMNNHAQISRQLRWDNLRNAMPPAAILTPQVMALLILLVACFNFTNTAIANSNRRLKEIGVRKVLGGTRRQLIKQFMTENLTVCLLALLMSLGIASYLVPAYGAMWQGLDLQLDLTQDFKFYLFLVGLLVFTTLLAGFYPSLYISRYKPVSILRGSLSIGGAGKLTKVLLATQYAFTVIAIFASVAFIQNARYQETLDMGFNRDQIIGVSLLNETQQQKIYASMLANPDIEQIASAKNHIGRGNYGALLKNQDLEVQTNMLDVGINYIEAMGLKIVNGRSFSKELEASDSQNSLVVNERAVEEFGWTNPIGQRVYLNDSTTLTVVGVVKNFYMYGFWAPIEPTAMRLKSLKFQDDGTYSFMVAKVNINHVKEVYDYLETEWNSKIPTKTFAGFYQDDLLREAKEVNNNILMIFGFLGTVAFVLSCLGLYTLVSINLIKRTKEIGVRKVLGGSVGHIVYLISRSYFLLLFISSVIGITAGFYLVDGLIGSIFNNYKPMDFFTFGIPSTTIIVVSLMIAGFRTLKSAMVNPVNSIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWC7</accession>
    <name>A0A654DWC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster biogenesis protein NfuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="95" mass="10397" checksum="A9D4E42884BCB558" modified="2020-04-22" version="1">MADLELLEKIESALDTIRPYLEADGGNVKILEVTDEQIVKLELLGNCGSCPMSTMTLRAGVEEAIKRAIPEIRGVEAINITTPDDPRAKLPETMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWJ7</accession>
    <name>A0A654DWJ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025071209" description="Por_Secre_tail domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1366" mass="143376" checksum="65C865E8A22E3195" modified="2020-04-22" version="1">MKASQPVFFALFMIISSTAFGQFYWVGDGGNWSDYSSHWATTSGGSTFHTNVPGAGDDVFFDANSFTTGGQVVTLDQMGTANNVSFSGVINSPIFTGAFGLTIAGDLTLDDDLAFTVTGDLTFTSSGNITVELGSIARSLPDFYFPNSSGTIQINTGSAANTVDRVVFGNITVSTAGVTFRVESNNLNSNAKTFGVISLPANCSYSIRGPNGSGFGVGDGNIFSGDFIVGDGGDGDFRGDYTIFQGNVDLGADGEVRWRDQVEFEADLTIDGSSGSDIIFSQNMELDGDFNLTGSTIVVFDRSATIGGDIVVAASTVSSIRIDRATTVAGNLTVGTAATLSFTNTNDNSPSLDVSGAVSLSDNVILTLGDGVDAPYTLGNIACGASVDITFNNGAESVSLASLTMGDFNIVRFNSASSGTSFSGNLISNGDCASWRTIRSNAEGVQADLSFGAAQSADANVIQDIAVSGASFTNNSGIDHGNNSGITFSGSHSPVNLYWIGGNSGNWSDESNWSTTSGGAAGVCVPSSADNAYFDANSFSGIDPSVTLDIAGAEVQDMDWSGVNTAVRWEGLVTNTLYVFGDLVLDADVTANYLGNIIFTMASATTNSITTNGVSLMGTVEFDFTGGTWTLSDDLDINGDDADLIITNGTLSAGSHTIALENNWTVSAGGSFTAGTGTVLLDGQNSSGDQEVDAGGSPFYNLTIDRQSSGGSSTVALLSDVTINNDLTIQRGRLEDGGFQITGNAGGTLTVQNGEWLRLGSNTVASLFPIGFGSVSLGNLSIVEYRSRVDQDVEGGITYGRLFLAGGGNASRSKVLQGAITVNGELRIDDYNDFFDNGYQITGASGQTFRMDANSSFTIGTSTTTTQFPTGHDAFNIDASTEIIYASGQDDGQVIKALNGGGNSSYGSLTLINVAGVQRIKMLEGDIDIRGDLNIGDANTMDLTASNYTFDLEGDLNITGSGMIDFRNGSLTLDGSAEQVLDFGGSTPLIHDLIVNNASGVVLADDLTIGNSLDLQNGIVTPQAAEVITMNAGSFIVSVSEASFIDGEIQKIGGTAFTFPVGDGGSYRPISISASGTSTDAFQARYFASSPHSSYPINSREPGLERVSALEYWTLSVTNGSPTVDVILSWDALSEVENLDDLRVAHWNGSSWDNYGNSGTSGNVTGGTITASGVSSFSPITLGSSSLDNPLPVTWLYFTAERNSSEVELKWGTASEVNNSHFAIQRSQNGEIWRELGSVIGHGNSKEKVHYTFVDKYPPSESTYYRVKQVDFDEKYEYSEIKMVDALTIGSRLSLYPSPAQNVLKVRSEDYVVKLEVFDLSGVSVMPRLGGFFDQEIDVSHLKNGLYIVHIQYHEGSATHKLVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX21</accession>
    <name>A0A654DX21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HU-HIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041607">
        <property type="entry name" value="HU-HIG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005902">
        <property type="entry name" value="HU_DNA-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18291">
        <property type="entry name" value="HU-HIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01201">
        <property type="entry name" value="HU_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HU-HIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14035" checksum="FCE4BA193AAD8C03" modified="2020-04-22" version="1">MAINYKVVSKRPAGIAGDKPTKYYPVLTKRKVANTRKIIDRISKNSTLSGADVVAVFESLRAIIPELLGSGMNVRLDGVGTFSIHARSKGQDTPEAVTSRDIDSLKISFLPDKDVKSMLKTIDFQKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD9</accession>
    <name>A0A654DXD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="274"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="523" mass="58935" checksum="963604334FC5A636" modified="2020-04-22" version="1">MKRIITYLVVIAVISSCADLDLVPKDAQSELNYWQTEEDARIFLNSMYADLMSADSYLLLSALSDDAYTRAQEGYRNIANGNYDASNGVVRGMWSGRYASIRRSNIFLNNINNVVEISEEKRAAYIAEARFIRAWHYFYLIELFGDVPFITDEISIEESLEVTRTDEAEILGFIYDELDLAISDLPSDVAGDQQGRITSGAAIAFKSRVHLYNGQHSEAAALAGQLIDEYALFPDYGGLFNMANENNEEVILSLQYVPVDREHGIQYFLIPPSLGGYANFSPLQELVDSYPMANGLAIDDPLSGYDESNPYQNRDPRLSATIIHDEYSLTDFSGNEVTIDTSPGAEPNGLNFSSNSTPTGYYVSKFYDQQARNVSNSGLNLIVIRYAEVLLNYAEAKIESGTFTSADWNNTVRQIRERAGLSGAAALNYPGNDQEALRTIVRNERRLELAFEAGHRFFDIRRWQIADEVLDGWAHGIQTNVSPQDDGYERVDLRTFDTDKHYLWPIPQSERDINDKLSQNPNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN4</accession>
    <name>A0A654DXN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="42433" checksum="611D18537AD801ED" modified="2020-04-22" version="1">MIFEVPFVSGPPTDLQNKYINEVVSASDSFWKKSLTRRCEGWFFNHLGGERYFVDSCTTALGACAILLNLRPGDEIIFPSFTHVSTVVPFVIQGAAPVFVDVEGSHFCIDADKVSEAITDRTRAVVAVNYGGWAPDYVKLRELCRQHQLKLIEDNAHGMGAVHQGCRLGTFGDYAAFSFEKQKNITCHEGGLLLINGEDSLEQVEKLMNLGTNRLDFDRNKTSHYEWVGLGLKASFTELQAAILLPQLEDLERITSDRRSAWRRYHDQLVPYADKGFFSVPPVLKEGDNAHLFYLILDDQSIRDQLRAYLNAQSIEAQFHYFPLHRSVFGSKVGRFVGDDHHTSIAGMHLLRLPLFTGISPDQLDRVVAAVIQFFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXQ9</accession>
    <name>A0A654DXQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD(P)-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ygfF</name>
        <name evidence="1" type="ORF">MARINOS108_11154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="26652" checksum="A95EAA22F1F9AC64" modified="2020-04-22" version="1">MRKTLLITGASRGIGAATALLAGKRGYNICVNYLSNSEAASQIVNQIKTDGGHAVAYQADVSKEAEVLSLFQKIDRDFGPINALVNNAGILETQSRVDQMDLERLMRIFNKNVVSAFLCTREAIKRMSTRYGGSGGAIVNVSSIAARTGSPNEYVDYAMSKGAIDTFTIGLAKELAAEGIRVNGVRPGFIYTDIHADGGEPNRVDRIKETLPMQRGGQPEEVANAILWLLSEESSFSTGSFIEVTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY5</accession>
    <name>A0A654DXY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="17482" checksum="84BA2016D819A7CD" modified="2020-04-22" version="1">MPNETIIQIRKLSQLYAYSSTQMHEAIGRKAGLTGTDHKYLGFLIQKGRMTAGELTTLTGMTAGAVTGLIDRFEKKKLVKRRLDKNDRRKVFIEPNTANIVALLEPLYKDFQDSTDELFASFSDTEIKTLEAYFLKAIEIMNEKTSSLRSGITPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY05</accession>
    <name>A0A654DY05_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">srpH</name>
        <name evidence="9" type="ORF">MARINOS108_11561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SATase_N" evidence="8">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="30739" checksum="63D13093B6A90545" modified="2020-04-22" version="1">MMDQNFIHKIFHSHQEYTKIPATSSIIGFFNDLLGVLFPDFSSHPAKSEEQVGQILEQLQTKLKSILTNNISLSGDNKQEIIEAFFTSLPVLYDRLALDIEAMFQGDPAASDHSEIIRSYPGFYAIASYRLAHELALLGVKNIPRIITEHAHSKTGIDIHPNAIIGEHFCIDHGTGIVIGETTVIGKHVKIYQGVTLGALSVDKKDAKVKRHPTIEDHVVIYAGATILGGKTRIGKHSIIGGNVWLTKSIPANSRVYYQALMHEDNESKPDLIIVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY13</accession>
    <name>A0A654DY13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="362" mass="39862" checksum="E2CA86F9B9507D14" modified="2020-04-22" version="1">MKEQTDDMARSLRVIKNILVVFLAIVILYLLKMLSNLFVPLAFALFFAILLQPLVSLFKRKFSLNVSVVLTTIFSVIAFLLIGFLFYNAVSAFVSNRDDILAGVTAELKPMIDRVTSLMGSELKEDELKEYLSRVVPTDQVLSLSGSFLNTLSGFATELLMTILYFAGLLGAIAQYEKVINYIMGKNGAGEESSASDTFRRVKDSISIYIKVKTVVSLMTGLGIGLISWAFGIQYALLWGILGFVLNYIPYVGSLIAIVPPLIIGGLTATSISEVFFLFLALEGVQIVMGSIVEPKMTGDSLSINTVTILFSLVFWAFMWGTAGMLLSVPLTFLIKVILEHVSDAGFLVRLMEKKSGEQFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY71</accession>
    <name>A0A654DY71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024974332" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="19510" checksum="3ADFDC57B1A07155" modified="2020-04-22" version="1">MKTLLLLSAMVACLSLQAQNQFQNEASGTLAFYSDRIMQLADAVPADKYSWSPEEGVRTFGEVLAHVVSANYFFAMKMGAVIPETVDMMGIEKTLKTKEQLKTALQDSYKVVIDVVKNSSKADLEEKVEFPFPGEFTSMSAALIAVSHSSEHMGQLIAYCRTNGITPPWSVTDEGGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY87</accession>
    <name>A0A654DY87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045749">
        <property type="entry name" value="DUF6090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19578">
        <property type="entry name" value="DUF6090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="29710" checksum="B4AF6D2343175088" modified="2020-04-22" version="1">MIRFFRRIRQKLLTENQFSKYLLYAIGEIVLVVIGILIALQINNWYQQHLERELEEDYYCQFLEDVNQDLIQLNEQVQYTQDRLHHANKLLGLLQIGDGDFEEILEHTKGAVSKTDAIITPNMNAFEDLKSSGNLRLITDKNIKKQLTEYYAYEQGLLNVINSNAISITTRFKEKADRINNGWVYLIESQNGFDSTLVSVEKLKALSVSNEEITLKHMNDALAYIASNSRNLEHLKSLESNIFLMKATLETRCTGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG1</accession>
    <name>A0A654DYG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="419" mass="45805" checksum="2581F2D1DF46E4C5" modified="2020-04-22" version="1">MKVKGLRWWIIGLICLATVINYIDRSALSIMWPSISEDLGMSKNDYALILNIFMIAYAVGQSVSGRMFDKIGTRLGFVVSISVWGVATMLHALARGLFSFSAFRVLLGLGEAGNWPGAVKSNAEWFPVKERAMAQGIFNAGAALGSVVAPPLIALLWVAFGWEVTFMVVGAIGLLWVLPWVLVNKAKPNEHPWITEEEKKYILAGQSEADNNPSTEGLSMKQILSHRESWAVLISRFFVEPIWWLFVGWMPIYLAETYGFNVKEIGFFAWVPYVGAALGSLSGGYFAGRLMLNGASVDRARKLTITIGGVIMFLGLLATILLADSPLIFVVIVAFVLFGFQFIISNIQTMPSDLFSGKSVGSLAGLGGTVGVFSVIIMNFLVPIISEISYTPIFIMIAVFVPLGVASVYFFAKEIKPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH2</accession>
    <name>A0A654DYH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="333" mass="37702" checksum="96DE005C06B31FE3" modified="2020-04-22" version="1">MDRLTRIRKYFDGELSQKEAENFLEWYLSEKSEEEVYAEIDKLWQAKGKSEFEWNGDELYKKLASKKDNERTLGVSRHIQAPKRGNQHRWWKVAAAVLILAVSSVLLYNQAGPTSTPEPMARVVKTNPAGQKSKVYLPDGTIVSLNSESSISFIDEFAEGRKVYLVGEAFFDVTEDASRPFTVYSGYLATTALGTSFNIRSYNNEQTEVTLVTGKVKVEKNNSNEIVYLTPGERAALGTDQSIIKGKADLLAVTYWKEGVLYFDKTDLNEVVETLERWYGVDISAFGDLPSIKCSGTFQKNEYLSNVLDILSHSVGFRYQLEGKKVKLEFNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH6</accession>
    <name>A0A654DYH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="196"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="34270" checksum="47D223A7297838A8" modified="2020-04-22" version="1">MSDQKNFDSIKAYNDFNNHPTLHPLVSVLDFSKANPRHGYKMSFGIYSIFLKDVKCGDLVYGKNTYDYQEGTLVFVGPGQVVDVSNKTDIYQPSGRGLTFHPDLILGTPLARQIDEYGFFSYNLSEALHLSPEEQQTIVDCFLKIENELKRPVDKHSRKLIASNIGLLLDYCERFYDRQFITRAHVNNGILGRFEESLNNYFASEKPYSLGLPSVSYFADELHLSVNYFGDMIKKETGRSAQESIQTKLIEIAKDKIFGSEKSVKEIAFELGFKYPQHFSRLFKKRVGYTPQEYRQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI5</accession>
    <name>A0A654DYI5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="DUF1593"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="DUF1593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025070634" description="DUF1593 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1593" evidence="2">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="482" mass="54422" checksum="09867EE514D72F39" modified="2020-04-22" version="1">MFLQIPRAVLSLCAFSLLLVSQTLYAQDYQKNRVIILTDIEADPDDSQSLVRLFLYANQIDIQGIIATTSCWHTSEVNPASIHKIIDAYGEIRPNLLKHEAGFPETQTLSTMVKEGLPRYGMEGVGDGMDSEGSEWIIKILEQEDDRPLWISTWGGANTLAQALYKIRKTKTEAEVKKYVSRLRVYTISDQDDSGIWIRNNFPDLFYIVSPGDDYGSATWTGINSYVQGIDNTTISNRWIAQNIQQNHGPLGAAYPDVAWGVEGDTPAFLSLIPNGLNEPEHPEWGGWGGRYELYQPDFSKTKEGGSIVTIAPETRAIWTNAIDRYTPYLPNEYGRSVKPDSVTFSDDKVTLWRWRDDFQNDFAARMDWCFMSYEAANHPPVPVLTHPEQITVKSGAGFTLDAFDTTDPDGDSFSFLWYHYPEAGTYKKSIEVNGAENVHLAYFTAPKVDQQETAHFIVKVTDRGEPQLSRYKRVIVTILPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK6</accession>
    <name>A0A654DYK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMP-30/gluconolaconase/LRE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024974104" evidence="1">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="31850" checksum="FAB2A7F8213BBA4E" modified="2020-04-22" version="1">MIMKQTIYLALALLVVACSQPKSNEGETASSETAEPTLGLEKLWATDTLLTTSESVIYDETNDVLYVSCINGAPPDARDEDGFIAKVSPADGSIIELQWVTGMDAPKGLGLIGSTLYVTDIDDIVAIDVTTGEITQKINVPDAVFLNDITTDDEGNVYFTDSGANRIHKLSADGELSLWIEDAEIGGPNGLLDDGDQMMMVAFGKGIFNTIDYASGTITQVTDSLQGGDGIEKTGEDYLVSSWHGRVFYITAAGETTKLLDTSEDGSNAADIEFIAKSNTLLVPTFFGNQVVAYKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM0</accession>
    <name>A0A654DYM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">uxuA</name>
        <name evidence="7" type="ORF">MARINOS108_11791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="395" mass="44284" checksum="2768561099CF6B6D" modified="2020-04-22" version="1">MKGLEQTWRWYGPKDTIPLSHIKMAGATGIVTALHHIPNGEIWTKEEILKRKTEIEQAGLTWSVVESIPVHEDIKKRTGKFEQYIENYKTSILNLGACGIDTVCYNFMPVLDWTRTDLSYEMPDGSRALRFDAAQFAAFELYLLKRPGAEEFYTPEQKQRAAETLKKLSDADQELLVKNIIAGLPGAEEGYTLDQFQTVLDTYSSIGDQELRNNLYAFLKAIIPIAEQAGVLMAIHPDDPPFPILGLPRVVSTEADAKQLLEACDSPNNGLCFCTGSYGVREDNDLPGMVERLGHRINFIHLRSTRRDAAGNFHEADHLDGDVDMYAVMSALVIEQDKRKAAGRTDLRMPMRPDHGHQMLDDLGKQTNPGYSAIGRLRGLAELRGLELGIRRSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW5</accession>
    <name>A0A654DYW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase accessory protein CcoG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccoG</name>
        <name evidence="6" type="ORF">MARINOS108_11891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014116">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_FixG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032879">
        <property type="entry name" value="FixG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13746">
        <property type="entry name" value="Fer4_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11614">
        <property type="entry name" value="FixG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02745">
        <property type="entry name" value="ccoG_rdxA_fixG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="54103" checksum="17FCA89D5EE8017B" modified="2020-04-22" version="1">MTPDITDLYKEQEEEASYRDHISTVDEAGKRVWVYPKKPKGKFTNYRMLVSILLLVFLLAGPFISIDGEPLLLMNILERKFVIFGQVFWPQDFHLAVIGMITTVVFIILFTIVFGRIFCGWLCPQTIFMEWVFRRVEYWIEGDYMKQKKLDRQAWDVERIWKKGSKHFVFLAISTVIMHTFMAYIIGVDQTWLLIQSGPAEEPVAFVVMVALTGMFYGVFSRLREQVCTTICPYGRLQGVLLDRKSIVVAYDYQRGETRGKYRKGEDREALDKGDCIDCKQCVYVCPTGIDIRNGTQLECVNCTACMDACDSIMDAIGKPKGLVRYDSEDHIETKTPFVFTGRMRAYSLVLLALMGVLVTLLMIRSDLETTILRTPGMMYQERPDGAISNLYQLKMLNKSNNIYPVKLELMEPSGRIEMVGEDIVLRKQGMEAGAFFIIINPEELDGLSTSVEVGVFSDGKLLETVTTRFLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY3</accession>
    <name>A0A654DYY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="212" mass="24461" checksum="DBD4F771F3BFC6AF" modified="2020-04-22" version="1">MMNRVKNIGLVLFLIVLPVFLENCGFDIEESDRYFDWVKKGNTLTYNLRSTEYRVDKYSLLKIEESSGISDNMVFREETLPQKNDVPYFGPLLSVFSDVYRLDDGLHTATCSSCVSNPCISIQHYLKVPAKSGNIESIPEYSCAEKIYGYDVILRTDSIIEVPFGIFRTLVIHDTIRRNVKFWNEEAGLIRVDNYNRLQGDTLILELVETNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ38</accession>
    <name>A0A654DZ38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="47" mass="5652" checksum="FE509940F5511D24" modified="2020-04-22" version="1">MQEINQNGVEILFFIIFILSALSDLLNFYFNEMQQVADSKGFWDFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ43</accession>
    <name>A0A654DZ43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024895154" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="16737" checksum="3BB56F51B1812C47" modified="2020-04-22" version="1">MKKLITFSIALLLAQAIYSQDITTKSYIEQTQVGNKLGTAIGYTFPCKVEIGGFYQKTADFMNAQEITERFYEKEFTGMYVNLPLKHYGKLNFDLNIRTGAVNGQNFAITPSILGSYSPVKAIKLGLGLGTRMFRPTLQASISIKISKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD3</accession>
    <name>A0A654DZD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="16952" checksum="3E8658C21152596A" modified="2020-04-22" version="1">MDVERLVANSEVADTPIIFFDGVCNLCNSAVNFVIDRDTDKQFHFASLQSDFAKGKLDQYQVDPSLLQSILLLKKGRLYHKSGAALEIGMLLGGPWRLLLVFKIIPKFIRDFIYDWIAKNRYRWFGKRETCRVPTPDLKERFLDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG8</accession>
    <name>A0A654DZG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="219" mass="24581" checksum="E44EB7FA453D8451" modified="2020-04-22" version="1">MKRIIITGATGMIGGIVLRECLNSSEVKSVTSLVRKSSGFSHPKLTEIVHQDFMDLSSVSQYFRNQDVAYYCLGVYTGQVPDDEFKKITVDYTRIFADLVYQNNPKITFCFLSGAGADPKEESKMSFARYKGMAENYLISKASGPLYLLRPAYIYPVEPRDEPNFSYRLMRKLYPLLKLVYPSGAITSEELSGAIFNLGFSENGSGVTILENKEIKQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI2</accession>
    <name>A0A654DZI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="46960" checksum="C6C3DDF344CC6201" modified="2020-04-22" version="1">MKNLLILGAGSAGTMMANHLTGKLPPEWKITMVDQREKHYYQPGFLFLPFRIYEPKDCFKSITEYIPKGIEYIQQGIEQIKGNENKVILDDGTSIAYDLLIIATGSRIAPEEVEGMNGPEWHQSVFDFYTFEGASNLREKLDNWDGGRLVVHITEMPIKCPVAPLEFAFLADCYFKDKGIRDRVTIDYVTPLDGAFTKPKAASKLGYLLKEKGINIVPDFAIARVDNENKKIVSWDEKEVPFDLLVTVPTNMGDDLMLRSGLGDDLNFVPTNKHTLQSEAFLNIFVLGDATNLPTSKAGSVAHFESEVLVKNILRYIDGMPPAEDFDGHANCFVETGNGKAMLIDFNYDTEPLPGKFPIDGFGPLKLLEENKLNHMGKLGFRWIYWNMLMKGRSIPFITPQMSMKGKKTEDKKVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK1</accession>
    <name>A0A654DZK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphogluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="366" mass="39789" checksum="51111F6D87D24FA4" modified="2020-04-22" version="1">MMNFRHLTALLLGIFVLSCTQKSTKMDLLIGTYTDQTSEGIYKVSFDTQTGELSDLQLAVEAASPSYLSISPDHKYVYAVGERGDGAVVSYAWGKDGLQRINQVSSMGINPCYVDFSADKKLVAVANYSSGNGAVYAVAEDGSIVGEPSTYQHEGVGLDSANRQEAAHAHCALFSKDSRFVYVVDLGIDQVVGYPVVDGAIGEGFTALQLTPGDGPRHMVFHPTKNLAFLINELSNSVISIDVDTETGRLTEIDRANTVPEDFTEHSQCADIHLSSDGKFLYGSNRGHDSIAIFSVGESGELERIGVESVQGKWPRNFTLSPDEKFLLVANKDTDNITVFSRDPKTGLLSYTDQEIEVSRPVCLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL2</accession>
    <name>A0A654DZL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="222"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="41814" checksum="2F2D229EE88D25DB" modified="2020-04-22" version="1">MSKPPLKWSITVLVMLLTATTIILYLIKSPSPEDQLGLARQHITTALKTNSGLYAQSSLDEATRLYDSAMTLWQRENERIFLFRNYDLTRTYAERAALLAITSVKEIHETQAKLKSEVSLQISQIQDHLTSFQVLYPHIPLKAQQVSDLALGKILFDQAKSAFQKENYPESKRKLDSAGLLIYTVTTYAEQTMENYMKAFPEWNHWVNTTIEESRKQKKTCLIVDKYARTCQVYKNGRLHKTYTSELSSNWIGDKHHQGDKSTPEGIYRVVKKKAGTDTRYYKALLLDYPNEADKIRFAQNKKNGVLQPSAAIGGLIEVHGHGGKGTDWTDGCIALQNDDMDVVFDQCPVGTSIVIVGSLVPFQTLISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU1</accession>
    <name>A0A654DZU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">msrA</name>
        <name evidence="7" type="ORF">MARINOS108_110050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024955659" description="Peptide methionine sulfoxide reductase MsrA" evidence="5">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PMSR" evidence="6">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD15875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="214" mass="24455" checksum="0AEB3AD62AF46826" modified="2020-04-22" version="1">MKNLFLIFVLSFTMSCNGNSSASQADQQVSDRNYSTLDTATFAGGCFWCIEASFEQIMGVKEAVSGYAGGDPSTAKYELVSSGRTEHTETVQIYFDPEVIDYSTLLDIFFTAHDPTQLNRQGPDVGTQYRSAIFYHNEEQKEHAEKKMAQLQSRYSGKIVTQLNPYIAFYEAEAYHQNYEKNHPFNPYIMNVSRPKIEKVKKQFSDRLKKEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ6</accession>
    <name>A0A654DZZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="160"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="31449" checksum="3782DAB100319D39" modified="2020-04-22" version="1">MFLTVHIPTYPINQLVESITYYSNYSVEHFAERLLPDGHADFIVNLTEAPKHTFDNTTLKVNDTFKKGWLSGARKKLLSIDAGGQNDSMMIVRLKFGAAYNIFKIPQEELTDKVYEADLILGSPFEDLRTKILEAHFVETKIQIMEDFIFARCVGVIDLPPVVTFAFHQLVHSPSNTSIKLLADQSGYSHKHFISLFKKHAGMSPKEFLKVMRFQRVIREIETYGSIDWTRLALDCGYYDQAHFIKEFKNFSGFSPEQYLSQKGDFLNYIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E053</accession>
    <name>A0A654E053_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="41911" checksum="FE696758BF458EFA" modified="2020-04-22" version="1">MIIFIAFSLIYCGFLLWARYHWCRIDTSVEADDGGLLTFSVIIPVRNEAANIASILADLQAQEYPADLYEVLVIDDDSDDGTLEIAAEVLQRSSMKYHLVRLKDYGMKGKKQAISKALELAENEIILATDGDCRVGSMWIRVYANKYTKDIQMITGPVRMVEHDFFTHLQSLEFAGLIGLGAASLQSGNPGMCNGANLSYRKSAFHEVSGYEGNQEIASGDDEFLLQKIFRAYPNGVLFLKDKRAIVSTPAKDTLGELINQRKRWSSKWKFHKSYYVKLMAIAVFFNYLVFAYMLVEGLTNEASFVIFTSFFLLRALVLSLYIRSVAVFLGVRNVIWASFVMEIIYPFLVLFLGIASIFGHYSWKGRYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E071</accession>
    <name>A0A654E071_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024975259" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="13659" checksum="8D3BD39805C916B1" modified="2020-04-22" version="1">MKTLAITITLSLFFGVTAWAQLEPIKVSDGYQVEIKTSAVCEMCKEALEQDLTFEKGVKSVNLDVDTKVLTIVYNNKKTDPTTLRKRVTLVGYHADTLQRDSEAYENLPLCCKDGAHQDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E099</accession>
    <name>A0A654E099_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22689" checksum="50E3F9891E7C80DB" modified="2020-04-22" version="1">MKTLLLLFGLMLSNVLWAQDFLRFSGVVLDREQITPIDGTYIFNLSRNHEAVTDSLGLFSIEAQSGDTLVFRDLRYQPSTLVVPSVLQASDYGIIQLLQPSAVLLNEVKVFSFPSEEEFREAFLKVSPKTDMESRALEAKRDLMKLLKDSYKNDIYYYDMWADRRLYELTGVVQPNHFLDPFRWTELIRSFGAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B4</accession>
    <name>A0A654E0B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="37095" checksum="3499215D2C6F384D" modified="2020-04-22" version="1">MGKVSIIMPVKNAEKYLKESIQSIQNQTSDNWELLAINDHSTDSSNQILQEFSAHDSRIRLLQNIGMGIIPALQQALRLATGKFVSRMDADDIMPANRLEKMSTLLEASGPKTVVTGLVQYFSDQPVSAGYQKYQEWINQVNRTGTQWQNIYRECVIASPNWIARRSEIQEIKAFENLRYPEDYHLTLKWYQAGFKVETVPEVMLLWREHNMRTSRTSEHYAQKAFFELKIKHFIDMDLQTNHLVVWGKNPKGKLTTDILSHHGIPFLWHDLKSYRKIESLENPQIIVAVYPDPKERNQLEKYLMNLGLMPGKNWWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E1</accession>
    <name>A0A654E0E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="521" mass="61626" checksum="7D0C265E00195CAC" modified="2020-04-22" version="1">MPTVGLRTALQVQHPWISKVGFNQRIMDLIREMVNVIEQDRPKTFNLLIPRDSKLKKLYKLVAAGGFLDDVSAARQLYQSDPGDKRFIMLKGSLINKLSELILATNHSELNRRNYTRIKFQCERQMTIARKLLYVNVYHNAERIASRVLKKARKYHLVEVELECFLTLRKVNYLKGFTGEVEKHQQAVSELIGQVRVLDVSKGLVQVVLSETKFIRSQRRELVTKCEKHMEALCAYHEQYESPFLRLYFLRIALVAAHQRNDFEEWGRVLELLKSHLREYAHLETEHVMLEVNVSTLKYFIATARLTQARPVLKKLLKSTSFEAFNRFEVLVEEFQLLMHQGAYREALKLLETVHEEPRFQELDKMDRAAWAIRSAYLFVISHMTGEPMKVPGFDFKKLHKFYHDCAPVSKDKTGYNLQFVVVRVILLRLKNTLEYDNEANNLKVYYQRYIKGDALLRTRAFYQCFVHLVKERFEEKAFYRERDQLIKGLTDHNDHLEYNELIRFELLTLLMEKLTRTRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E2</accession>
    <name>A0A654E0E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yffH</name>
        <name evidence="3" type="ORF">MARINOS108_11298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00052">
        <property type="entry name" value="TIGR00052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="21913" checksum="B91ABEF35F3DAEB1" modified="2020-04-22" version="1">MIEKVNILNTEILSDNWYTLRKITYEYLKKDGSLQTQTREAYDRGNGATILLYNKAQKTVILTRQFRLPTFINGNDSGMLIEACAGLLDKDNPEDCIKRETEEETGYQVSSVHKIFEAYMSPGSVTEILHFFIAEYAKEMKVSDGGGVEHEEENIEVMELPFETALNMISSGEIKDGKTIMLLQHLRLHQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M0</accession>
    <name>A0A654E0M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplW</name>
        <name evidence="6" type="ORF">MARINOS108_120496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="95" mass="10353" checksum="8C2D98B9FA627AD2" modified="2020-04-22" version="1">MGVLIKPLVTEKASALNEHGKYGFVVDKKANKVQIKKEVEKTYGVTVESVNTMVHPGKSKSRYSKSGVIEGKTPSQKRAIVKVADGDIIDFYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N2</accession>
    <name>A0A654E0N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="24531" checksum="9BE58C19540916B4" modified="2020-04-22" version="1">MRNYFFQNPFWISWLYPGAVWKVMTNKKELFLTFDDGPHPVVTPYVLAQLRTYQAKATFFCLGSAMEANQEVVKQINDDGHLIGNHTQSHLNGWATKTYQYMADVLACQTLQDEYSNDRLFRPPYGNLKLGQLRALKKAGYRIIMWSHLSGDFDRELDRKQSLDYMKKADPGSILVFHDSEKAFKNLKEMLPRVLEHFSTLGYSFKTLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S9</accession>
    <name>A0A654E0S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="134" mass="14827" checksum="7D890696A7312CD6" modified="2020-04-22" version="1">MSSIFSRIVAREIPAHIVAEDENFLAFLDINPLVQGHTLVIPKQEMDYIFDLDDEVLAGLHIFAKKVARAIEAVVTCERIGVTVIGLEVPHAHVHLIPINAVNDMNFGKEKLSLGKEDLMEVAEKIKAAFTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X9</accession>
    <name>A0A654E0X9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5606 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041218">
        <property type="entry name" value="DUF5606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18347">
        <property type="entry name" value="DUF5606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5606" evidence="2">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="18304" checksum="9F34A95888CF0F74" modified="2020-04-22" version="1">MDFNEVAAVSGKGGLFKVVSPTRTGVILEALDGSGKKIIANIQAKVSILSDISIYTTDEEGAVPLQDVLRKIHVEFKGDTGLTSSSDPDELKSFLKFILPEYDESRVYVSDIKKLVTWYNTMAKTLPELLEKKEEQEQAEEKPAEKEKKEAAPKAKKAAAKTKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E121</accession>
    <name>A0A654E121_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024926819" evidence="2">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="132"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="144"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="51620" checksum="112EA04F069355A2" modified="2020-04-22" version="1">MHRKHAILLLIFFQYFPLLAQKQPPTQRLGAFRYTQEDRKILSGQPTTALVLKSPHFQGQSVKIEVNGTAMAIPLDPDAPAYTYFLSLPEPIEVTKVDADPDWSVFLINSGNAPATSSRKLRADQEECDFNVDPILQEEWRNGLDAPSYSRSFTDVEHVIIHHAAGSNTNTNYTQVVRDIYIYHTEVNGWSDIGYNYLIAQNGALYAGRDPAGGEQDNVLGAHFCGSNSQTMGICLLGNYEAALPTDATWATLQQLAAFKLQKENLDALGSSAHPLGQVGNIAGHRDGCSTLCPGGNVYDQLSALRSEVDGLLSSCEVALDFELSELTLEAGESLTVSNTSHGYDSYTWLFEGGNPSTADWPNGGEVQYNYGGVFDIALIGHQGASADTLSFQDAIRVLAEPRIFPNPAKSMTTLNVATDGSIKALEIIGIQGKTHFATNEVEGGITLPYLTSGVYVVRIHTDGRWVSQMLLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E135</accession>
    <name>A0A654E135_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="23027" checksum="260EA92BBDFBC52E" modified="2020-04-22" version="1">MSFDRVAWIYDQLAGLVFGSQWDQVQQAPVGNLAGKSRVLIVGGGTGLLLDALQDVEKIVFLELSEKMIARSRNRGSHPRVDYVHADFFQWETSEKFDAIVMPFFLDCFGTEKLEGAIFKARTHLTENGELHVIDFQSASWWKNSLIHVMYLFFRLFSSLEGKTLLNIDGAIRNAQFGQKSESFLCDKWIFYSVYQPNRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A3</accession>
    <name>A0A654E1A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="535"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="660" mass="76320" checksum="F1A22C32B9D84EF3" modified="2020-04-22" version="1">MNGEKIRLFCLFFILVYGTSPLNAQRITTKRISTDSVPEDVHLNIYDFKNINKLPDYYNAEQLKRINKLDQEEDWEGLYKALKAYVSKFGIQNFYKDTKLIWRLAKLTELFGDDEEAKNLYRLVLRHHHSGINMKEIELYYDSLNDQEAAQYVPLDYYYELVEYRTLIDTLRPPRGILLNMGQEINSAKADYAPSLNVQNDVLIFTSQRNDLDLSIRRTFNEDLFFSRKDEYGSWSKAEEFKEINSRYKEGSAILTRDGKTLYFSRCDCLDCFGDCDLFSAKLQSDSTWGEVKNLGTRVNSLSWDSHPSLSHSEDTLYFASDRLGGFGLSDIYYTYKLKNGEWSSAKNLGPVINTRNNDVSPFYHPVYNVLYFGSNGQLYNFGEYDIYKSYQVGGNWSEPYNIGPLVNGKGSEYYFTIDSKSELLFYARSISRDLNKQDIYSFPLPMNAQPLATTKVTGSLTDSLTGKAFRGIVSIIDLDEGVEVAPRYLRPDGSFEFDLIDQRNYLLVIQGDDFFRIEDSFFLDGTRELKKVTEPLASRVKFESIEFDNGKSALKKEMYSDLNKIVNFLYDNPDFKLKISGHTDSYGSDEHNLRLSQERARNIRDYMVDFAGLASERVDWEGYGSSRPIVEEINEEAKAINRRVEFEIYRPAPQPPSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D4</accession>
    <name>A0A654E1D4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusC/RagA family TonB-linked outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025049400" evidence="5">
        <location>
            <begin position="24"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="118"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="431"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="983" mass="105849" checksum="EF5E2FAD6CCEAE61" modified="2020-04-22" version="1">MKQHYSRCLLTFLALLCLNVAMAQEIDVSGTIMGGENGEPLPGATVMVKGTTNGTITDFDGKFKLKAPAGARLLVTSIGFKSAEVDASSNVTLTLEEDVTRLNEVVISGLASTVKRGNLANSVASISAKELTTMSNQSTMDGALYGKFKGANIVSNSGAPGGGISIKLRGLTSINGSNEPLYIIDGVYLDNSSISAGLNVVSAAAGGGSQSNQDNPSNRIADIDPEDIASIEILKGASAAAIYGSRASGGVVIITTKRGERGETEVTLSQTVGVTQILNPLGTREWDAAKVEAAFGADEVANFQSAQAAGNLHDYEDELYGNKGFLSTSRVTATGGSDKTKFFMGITRKDDEGIVKNTGYEKTSFRLNLDQKIASWLDLKASTNYIHSSADRGFFNNDNSGNTMGIAFVATPSWAQLGKGSNGLYPNNPYAASNFLQTRDLITNNETVNRFLVGGTVVARLITQDNQSLRLNVNGGIDQYTLSTTAIFPNTLQFQKDGNGLNGVSVQGNTVTQNSNASIFLIHDFFPGSSGLSFTSQVGLTFIDFDQNNIIATASDMNGTQTNLDQSGSVSVAQNRIIQQDRGFFIQEEVNFNDMVIATAGVRGDKSSNNGDVNKLYYYPKGAIAINLHNFDFWNVNFLQQTKLRAAYGEAGNFAVFGDKFSALNAVNIDGSGGLIISNLKGNREIAPERQSEFETGIDFGLMDGKISIDATYYVKKVDDLLLRAQIPSSTGQTTAVVNAATMENRGVEIGLNMNLIRRENFSWSSTTSFWRNTSEVTRLDIPSYTVGGFADFLGQFRIKEGHSPTEIIGVGANPDEDGLVVFGDQQPDFQMSFLNQVNYGPLEFSMLWHWKQGGENINLTALLSDLSGTSPDFDKVDLDPEGELGNGDYRLSQLGANTAPYIENASYVRLREVALYYKLPVLQDYAKSVKIGVSANNLLNFFEYRSYDPEVSNFGGQGLSSGVEVTPFPSSKRYNFHLIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F1</accession>
    <name>A0A654E1F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="80" mass="8738" checksum="8F65D9C3547AAC11" modified="2020-04-22" version="1">MDYRLVAVDLKTGGLAQLARAPALHAGGHRFESDILHTLLQVKEKGVGIKQTELIALDIRSEVLLATHLDVVDYIDQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M6</accession>
    <name>A0A654E1M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025634">
        <property type="entry name" value="DUF4292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14125">
        <property type="entry name" value="DUF4292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="29540" checksum="8DCA9EF4565C8244" modified="2020-04-22" version="1">MRRKLQTGNYTNSWLGVLLITLILLTGCNKKFSGIFDRNSTRLVVNDAKFDFLSSKAKINFESEKNNVSGSANIRIRKDSIIWVSLSPGLGIEAARVLITTDSVTVLDKINKVYMKYSFAELSKKLDFDLNYSLVESAMLGNLVYPYDRERLVRTASTYAYSQQHSSYLFENFIGTESMKLEKIQVLDTLSRNTISVNYTDFQLVDQEVFPFQISAILEYAKKGTDPVKVIIEFKQTEIEKKPLKFPFNIPQRYDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1R3</accession>
    <name>A0A654E1R3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">fabH</name>
        <name evidence="10" type="ORF">MARINOS108_120228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="240"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="35837" checksum="BEA79145BC1F08B8" modified="2020-04-22" version="1">MTKIRAAITGVHGYVPDYVLTNHELETMVDTNDEWIRSRTGIEERRILKGEGQGTSVIGAEAVKGLLAKTNTKAEEVDLIICATVTPDMPFPATANIVADMVGAKNAFGYDLSAACSGFLYALATGAQFIQSGTYKKVVIIGADKMSSIIDYTDRATCIIFGDGGGAVMLEPTEEDLGVMDSILKSDGSGAPYLHMKAGGSRKPATAETVAQREHFAFQEGSTVFKFAVTNMADVAAEVMEKNNLTSDDISWLVPHQANKRIIDATARRMGVGDDKVMLNIQRYGNTTAGTLPLCLWDYEPQLKKGDNIILAAFGGGFTWGATWLKWAYDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X0</accession>
    <name>A0A654E1X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fido" evidence="6">
        <location>
            <begin position="237"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="320"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="389" mass="44750" checksum="526909E273C35EC0" modified="2020-04-22" version="1">MIQRAGQHVRLSFFVLGSCVFLFRILTIFVNIFIVMIKNLLRNGRVEKNLKLKELAAQADIDQTLLSRFEKGSRMPTEKQLNVLGEILGLDMRAARVEWMADKLVGMLQYHPEAMEALRVAESRVEYLTSKKVLDSPSLSEGLALKLEKLDALKAQWAARPVLSPSQLQRMHAFFDVEYTYESNRIEGNTLSLQETALVVNEGLTIGGKSMREHLEVINHSEAIAFVRGIVERREDLGRRSLMEIHRLILKEVDTANAGRYRQVPVRISGSETELPQPYMLDKLMEDYFEYYEVHRLRLHPVILAAEMHERLVSIHPFIDGNGRTARLVMNLILLRNGYTRANIKGSTESRMQYYRALQSIQEDNNPEPFYQLVTDESLRSIQAHLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E212</accession>
    <name>A0A654E212_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="7804" checksum="E1EE021153333B74" modified="2020-04-22" version="1">MLTLDTLKTNQSVTIKALTQNGLTSKLMDMGMYPGKSVQIVFRAPFGGPIAVDLDGYTLSLRIDEASLVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E261</accession>
    <name>A0A654E261_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="21672" checksum="8BF982FCB17F2FD8" modified="2020-04-22" version="1">MANEKAQIRRGVLHNRRLLVSEVFSKRNMEVTMAASQLISQKGARCVHSFLPITRNKEVNTWPLIALLSRVKTEVVVSATDFARQTMSHFVYTRDLLFEDDPFGIPTPIGGTPANLDKIELVLIPLLAADKQGNRIGYGKGYYDRLLTEMAPDVLKVGLTLGPLFDRFDFAEAHDIRLDYCITPQQTLKCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F6</accession>
    <name>A0A654E2F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4105 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025178">
        <property type="entry name" value="DUF4105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13387">
        <property type="entry name" value="DUF4105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4105" evidence="2">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="47895" checksum="3C9313E6CCBF73E6" modified="2020-04-22" version="1">MNHSPDMYWRLLVFSVLVLFFFKSEGREVEVSDQAEISIMTLGPYQEELYSAFGHSAIHFSDPERNIDWVFNYGVFDFDQENFYWNFARGRMLYKLGLSRYTPFKNHYARENRYIIEQRLNLTLAEKQAMVDFLTNNYKPENRDYYYNYVYDNCATKMYDVLVAVFPKQITFNADYVEDGKTIRDLMDDYLGDQPWGDWIIDIGLGMQIDKEATPREYMFLPDYIEASLSTASLRRDSLEVPLVGETVNVYVPTPEEQQESKFFTPFNFFVLVFFVVGFITNRDFKKEKRTKWLDPVVFTLAGLIGWWLVFLWWATEHLSKDNLNLLWAIPLHIPFAYLLGVRKLQPFLSKYFLVVSAGYLILLVIWSALPQPLHMALIPLILTMMLRGFYIHSDLQKQLRKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M0</accession>
    <name>A0A654E2M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="2">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ganB</name>
        <name evidence="3" type="ORF">MARINOS108_20170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="PTHR34983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="406" mass="45700" checksum="D14A54CC8DFD31DA" modified="2020-04-22" version="1">MNTNRLAMLSIIFSFIALVSCNTDDPRRGVDPDPENKDSVIVEQFYFGADLSYVNQILDHGGQYRDVGEVRDPYKIFKDHGANLARFRLWHNPQWTREVYGDAGTQLYNDLYDVEKSIRQAKAQGMEVLLDFHYSDTWADPGSQRVPAAWRGITDIDVLADSVYDYTLKTLNYLNQKGLMPELVQIGNETNCGMMLTGGVDGFPACNVCDGNWANMGAVLNSGIRAVRAVSVDSDIKTKVMLHVADPVNVDWWFEQATSEGGVTDFEFIGFSYYPIWHTGISLDRLQETVAGFVTKFKREVVILETAYPWTVQGNDNYNNLFGGESPLPGYPYTQDGQLSLMKAITQKLVSAGASGVIYWEPAWISSDMKDKWGTGSSWENNAFFDFDGNTIPTIDYMNYEYDTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q2</accession>
    <name>A0A654E2Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="85" mass="9674" checksum="1C800F2A481BA67A" modified="2020-04-22" version="1">MKKYGIHFIYVLIIVTLAVLSRIKTSGLEAECLNARESAEQNAMMAKEARQQAIEQAEVAKMEAYRALEAAEQARKMLEECQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y6</accession>
    <name>A0A654E2Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="741"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="105"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="398"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="875" mass="98668" checksum="BFE19513410FA97A" modified="2020-04-22" version="1">MKKSRTPSPPRLAQRIFQWWAGSADTEDLLGDLDEQFVYNLQTKGRRRSQWIYSLQVCSLLFSYALRKRKRAASYSTYYPNNSMAMLQNYFKIAIRNFQKQKLFTVINIVGLALGMSICLLALSMFVSIFRFDEFHTQKDRIFQVNTRIADRNQKDLYASTFNAVGDYMGEKYPFIEQVIKIKSGFNPEIHHQGNLMSFHGYFAGSSFFETFSFPLISGNPATALAEPFSIVLTKSVAETLFRDVNPMGKTLETATGTYRVTGVMADLKQTHFYFQVLTSHQTYEILHAGTNLQSDWKTYRNNYVYLLLKPNTSPEALSDALAQVSARASEFNPDRSIILESTKLARIIPSWSISNGLGVGWDLPTMIFFMALGLLILMPAIFNYTNLSVARALRRAKEIGIRKVVGAEKNQIRAQFVVETILLTFLALIGSIFIFKLIQTEFLTMIIGADSLDTSLSLSVLAVFILFSLIIGIVAGIFPAMYFSRLNPIHTIKGEIKSRSGGVSGIRKGLFVFQFFVSLVFIIGVGAITKQYAYVLNYNHGFQSDNILAVPFQNIDKQVVINEFKTHPDVKAVTAASNLPGLPLPIMVDITPNEIDTLTVHQVFIGEDFIENMGMTLTWGESGNQQRSTRNEELVLVNEQFLRSMAVFGAQQDSLVFSLGDGTRCRIVGVLKDFNFEPLNELIQPLVFLYSLAESNFALLTVHSKDIKKTINDLDAIWTGIDQKVSFEASFLDDKIEQAYYFLVIQIKIFGFLSALAIVISCLGLLGMVSYTTENRTKEIAIRKIMGASNNSLYYTLTKDFVKLILIAAVIAIPFSYFFYDMVLLRVFLSYSDGLGLPEMVLSIAFLFLVGFAAIYWQTFRVTRENPASNLRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E313</accession>
    <name>A0A654E313_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AsmA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="563"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="884" mass="96166" checksum="B9A581DC2D957E45" modified="2020-04-22" version="1">MKKVLIILAVLIGLVLITAIAVPIIFKDDIRAAIDKELDNSLNAKIFYDTEAFSLSLFKSFPDLSVTVGNFGIVGLAPFEQDTLVSVGEFGITLDIMSVISGDQIKIVNVSLVDPNIKVIVLEDGTANYDIAKPSDETTEEESIASEPISIQIQGWEITNAELIYDDATLPMVASIGGLKHSGSGDFSQDVFDMSTSTTVESFSLTYDGVEYISNKQLVADIVMAMDLANMKFTFKENKASLNDFGFGFDGYVSMPGDDIEMDITYGGKDINLLSVLSLIPGVYQEYMDGVTATGSVNFNGAVTGVYNEESMPKVTASFAIAEGKISYAEYPIPMEEIVVSAKFDYPSADLRETSFVMDKFHMKLDGEEVSAYLYFKDLEDYFWDFNMKGNLDLEKLTKVVKLEDMTLKGLVSADLSTKGRMSDLDAGRYASLPTSGSLGMDNFYFESPDLPQGFGIANTRMTFDPARIALTNFKGNAGKTDLNMDGEITNYLQYALADSAKLYGKLNFSSALVDANEWMTEETTTEETVDTAAMEMVRIPENIDFVLTSKIDLIKYDNLELKDFGGKVIIRDGALRLEKAGFNLLDGYFELNGAYESAMALDKPLYDFDFKIKDLSIASAFESFVTVQKLAPVAEKMTGKFSTDFKIGGSLGADMMPIYEEMQGAGLMEIAQATLKDVKLLSAVSNVSKLNQQDGEVSLKDVLLATEIKNGRLYVEPFDLTIGGRKATVGGSTGVDGSLDYLMSMDVPSGQVGQALNSAISSFAGLDNAIGKDITLNLGIKGTYDDPKVNLLSAQPGTSGGSSSVKAALQAQAKEKVDAKKEEIKQELEAKKDSVTTEVKEKVDAAKEEVKKEVEETKEEVKDKAKDAVKDIFGKKKKGDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E364</accession>
    <name>A0A654E364_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rimO</name>
        <name evidence="11" type="ORF">MARINOS108_20351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="156"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="389"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="456" mass="52003" checksum="27B577A9AB6B5371" modified="2020-04-22" version="1">MNLLWGPFCISFAVLFGRDVKTKGLKKDKVNIVTLGCSKNLVDSEVMLTQLKGNSINASHESVKDDANIVIINTCGFIDNAKQESIDTILRYVDAKEEGMVEKVYVTGCLSQRYRDDLQNEIPEVDAWFGTMELPLLLKKFNADYKHELIGERITTTDRHYAYLKISEGCDRPCSFCAIPIMRGKHVSKPIEQIIKEAESLVRNGTKEILLIAQDSTYYGLDIYKKRNLAELLDKLADVEGLEWIRLHYAFPTGFPEDVLDVMARRSNICKYLDIPLQHGSTEMLKIMRRGTTREKTEQLLKTIREKVPGIAIRTTLIAGHPGETEAEFEDMLDFVEKSRFERLGIFPYSHEDNTHAYTMEDNVPENVKLERAERVMELQESISEEINSQKVGKTLRVLIDRKEGGQFIGRTEHDSPEVDNEVLIDASEHYLRIGDFANILIEKATAFDLYGKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E367</accession>
    <name>A0A654E367_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="12672" checksum="57A89E2F729929DF" modified="2020-04-22" version="1">MKETRLGEFEEVILLLVGILGEEAYAFKIAEEFEAQSGRASSIGSVHSTLDRLKEKGFLTSEMGQPTAERGGRRKRIYTITAAGQAALTSSRDFRVSLWNQYPGLSVDRLNFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L0</accession>
    <name>A0A654E3L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024968575" evidence="1">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="22879" checksum="BA7BE28695D4428A" modified="2020-04-22" version="1">MRSKRYLTAVLFALTLCSSGLLINCASYSSFQTARTLPQGKVSGTAGLGYNYLGEESFVDLALRVGLEDSVDIGLKANFTNWGSTLIMGDIKKQLATQSPNFNSALGIGLSAVTADDEGVALHFPAYFSFHSSNQKLALYLNPRVFYYLDLRNSQERSHNNSGLGAGNSVGLKLGNRFAIMPEYSFFVGQYNDELKVNNLFSVGLGFRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3N4</accession>
    <name>A0A654E3N4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="271" mass="30330" checksum="85E45A9B3BD3BA55" modified="2020-04-22" version="1">MQNLLYFLYRFRTFGLFLLLEGICAWLIIGYNNQPNAAFLNSSNRLVAGINTLTSNTGDYFQLKTINDQLIRENLLLREQLANVSLGLVEIDSSVRKYNLFKAKVINNTFQRSMNYLTLDVGSKDQVLPGMGVIGGEGVVGQVKSVSGNFATVTSLLHRNLMISSSVKRTRTLCTVQWDGNSPLEASLKYIPRHIPINIGDTIVTSGFNAVFPENIPIGTISEYQLEDNDVFYEAKISLAVDFSSLEYVYLVQNVMKAEQDSLETETQMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T1</accession>
    <name>A0A654E3T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase RpoN-/SigL-like sigma 54 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_20865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="11">
        <location>
            <begin position="104"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="10">
        <location>
            <begin position="317"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD19767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="477" mass="54703" checksum="F03FDDBC14E2BA01" modified="2020-04-22" version="1">MQKLNLTQSLSQKLSPQQIQFIKLLQVPTAELDTRIEEELEINPALEEGLPEKEDDYADDAPDEFDNSEPTIEEYLHDDFSGYKMQGDGRNPDEDDKEMPISVGSTLHEQLMTQFGYLRLDERQHVIGEQLIGSIDADGYIRRELEAIVNDLAFAQNIETDVEELESILYKIQNFDPPGVGARNLQECLLLQLERKDEELEYLEIARLIVDKCFNEFSKKHYDKIAKKLGIESEEALKDAIAMITKLNPKPGGSGEDLVKTQYLIPDFMLTNNNGKLELTLNSRNAPQLQISRSYSDMLHAYDKSDKRDKKLKETVTFIKQKLDSAKWFIDAIKQRQNTLLNTMQAIIDFQYEYFLEGDEAKLRPMILKDIADTINMDISTVSRVANSKAIQTEFGIYPLKYFFSEGIATDSGEDVSSREVKHKLKGIIEGEDKAKPLSDDKLEKMLRAEGYNIARRTVAKYREQLNIPVARLRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T3</accession>
    <name>A0A654E3T3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fcl</name>
        <name evidence="4" type="ORF">MARINOS108_20580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="34323" checksum="768412FA2078342E" modified="2020-04-22" version="1">MEKDAKIYIAGHRGMVGSAIVRKLQQDGFTNLVFRTSSELDLTNQKAVEDFFTYEKPDYVFLAAAKVGGINANNIYRGQFLYENLMIEANVIHQSYVSGVKKLLFLGSSCIYPKMANQPIQEDSLLTGPLEETNEPYAIAKIAGIKLCETYRAQYGVDFISAMPTNLYGPNDNYDLANSHVLPALIRKFHTAKATDAQEVSIWGTGSPLREFLHVDDLAEACLFLMENYSSEKTINVGFGEDLSIKDLALMVKDVVGFSGALVFDSTKPDGTPRKLMDSSKLRALGWMPKISLADGIRKVYSEVDKSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V2</accession>
    <name>A0A654E3V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="85" mass="9461" checksum="5FFA7212A1510F9C" modified="2020-04-22" version="1">MIIKDSGIRPALRSVRNRNDVRENAVSELLSSIPVCEVRSNTGITSIMGNDQIKQCLREKADFLNPQSAFLLNISDLIEDNVGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y1</accession>
    <name>A0A654E3Y1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disulfide bond formation protein DsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024841722" evidence="2">
        <location>
            <begin position="19"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC" evidence="4">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="3">
        <location>
            <begin position="184"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="650" mass="72528" checksum="D0C547B9037EC18C" modified="2020-04-22" version="1">MRKILFLTAVLWGSFSQAQVLHPATWKVSVSPSTPNAGEEVIISFDVKIDEKWYLYSNDFDPDLGPMLAEFVFEPHVGYELVGETLPINPKRKYDSLWEGEVSIFYEKARFTQKVKILDPDYVIKGTYEFQVCTDATGKCIPGDGEFEFRGRKAGTAGAKESTGLLQKRDSTDPYSLLSFMLVAFLAGLAALLTPCVFPMIPMTVTYFTGKDNHKKGRLINSFFYGFCIILIYSLIGAVLSPFMGPETANDLATGWLPNVLFFIVFVVFALSFFGLFEITLPHRWVNNVDQLGDKGGLIGIFFMALTLVLVSFSCTGPIVGSILVESAGGLSLKPILGMFAFSAAFAIPFSLFALFPNWLKSLPKSGGWLNSVKVVLGFLELALAFKFLSIADQAYHWGILDREIYLAIWIVIFTMLAFYLLGKIKLPGDSELKTVSVSRLMLSMATFAFVAYLIPGMFGAPLKALAGYLPPVSTHDFDLVSEIRDSGLPLDTPKGCEEPLYADFLHWPHGLRGYFDYDQALACAQKVNKPVFVDFTGHGCVNCREMEARVWSEPAVLNRLREDFVLLALYVDDKTELSEDQWYTSEYDGKIKKTIGKQNADFQITRYGNNAQPYYLILSPDGTILTEPKAYDLNVDNFVLFLEQGKTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Y3</accession>
    <name>A0A654E3Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnogalacturonyl hydrolase YesR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="44852" checksum="712D3827FE8FB8D4" modified="2020-04-22" version="1">MDRREFTNLIMLSGVGSMVLAPGMASAGAKLFEKSDGGFPDNLPDNLRKMVENTLAKPYSEITTNWDGSIQIEGLLRFAKRGHEASFTYAKEWFEYRLKTDSQMTDEEYFQQYITKARARINRRGPLTFSIYSANLGVAFPVYDLYKLTNNPIARTVCLDVADAILHECARDRYGMVAHDDGNFTRFAIPDTTYWATRANAIAGNLTTGELSEVYYKQAIIQLDTGIDIFLDKKTGLVITGIFDDVIGKTYWCRSQGWLLWSIVGLLRNLPNTHPRFEYFAKQAETIADAVQKYQGKNGGLHVLVDDPTSPEEVTGMAMCLSAMKESVRNGWIPDQYSAFFEKGYDFLKKSVDENGNITNVYTAWAKTAEAKEVNRMNENFRGFVPGILMVAADEMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z8</accession>
    <name>A0A654E3Z8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="6">
        <location>
            <begin position="229"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="355" mass="39764" checksum="044FA82F2838E0D4" modified="2020-04-22" version="1">MNYKIVNIRTTASVDPVDSILIIYTGGTFGMAYDESGALAPFNFGRVIDRIPELKGLELRLTVISFPEPRDSSNINSQDWQDMAYIIYENYAQYDGFVILHGTDTMAYSASALSYMLQGLNKPVILTGAQIPIGSIRSDARENLITALEIASAKNDKGPIVNEVCIYFNYYLLKGNRSQKIRSSTFAAFQSQNYPYLAESGIDIEYRLNYMWPHNARSKLKIKKEFDENVAILKIFPGINQQTVESIFNIKGLRGVVLETYGSGNTMNFPWFIKSLQKAIKKEIIIYNVSQCSGGEVIQGRYETSKRLNDIGVLSGGDITTEAAITKLMFLLGTEKSLDEVRKKLVIPLNGEMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E472</accession>
    <name>A0A654E472_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="55"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="39272" checksum="8F6EBD7AD55DAAA4" modified="2020-04-22" version="1">MKGKGAQYNPSNPFFKQSMGQYHDEGIDEYTQEERPNTTIFHESPKNVLSKNNSPDLQFTYSVNPYQGCEHGCVYCYARNSHTYWGFSAGLDFESKIIVKDKVAALLDAQLSKISWKPQPIMLSGNTDCYQPIEKDLKLTRGILEVMLKYRNPVSIITKNALILRDMDLLQALAEKSLVHVYFSITTLDESLRAKLEPRTATATKKLNAIRELSALGVPVGVMNAPIIPGLNDTEVPAILKAASEHGALAAGYTVVRLNGQIREIFEDWIKKSFPDRAEKTMNQIKELHGGKANDTDWERRLHGAGNYALMIDQLFQNSKKKYFEDKTMPPLNLSIFRKGGNYNLFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E473</accession>
    <name>A0A654E473_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="29158" checksum="D24BB6EE2D4F07FD" modified="2020-04-22" version="1">MEKISILGCGWLGLPLAKALIKAGHLVKGSTTHPEKISLLHIAGIHPYLIDLNPTYQGPKDFFESDLVIINLPPRNRNEDPSFHLKQLLSVRENMLVSRVSKVIFVSSTAVYPDLNRVVTEEDAAANSLSRAGISLLQMEHLFTEVPNLQSTIIRFGGLYGPGRHPGRFLAGKKQLGGAHNPVNMIHLDDCIGIIQTIIRDHHWNQTFNACSPHRQTRAEFYTLAAKDLGVEIPDFTQEAKPYKEVSSEKMLSQTGYKFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D6</accession>
    <name>A0A654E4D6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="44237" checksum="F12746465AF085FA" modified="2020-04-22" version="1">MTELYSDFIHKLKKLFGKFDESHKRFEKSSNSEIARELGYSDAQFSRLINESATAGEYQRAIQSIDRILMVVQLESELGRKLGGTQDWKKHPGWLGATVLVVLLLILTIIWRPGSYQELPDSEKSPRDNMLKWTFETAFINPYVKLDDLPEDCNYPCYKYQGKWELKEGYKIPFFRERNGFHYSATEVNMYARCMSEKDPKGKIIEGYEYQKHEIWYDRRELPIDSFIRKDLALKDFYKQLDFSLDNNFVKVATVHTFFRNEFEIDSLVIHRSGKVIGRDLEFTDQEELEELFSSKNLIKDILSELNRIATNRLEDFSRPITCEPAQVPSSNIHLIKDGDEMSFNCQLTTSRLAMNYTKTFVLKDQYIKNTCRVSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H4</accession>
    <name>A0A654E4H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">infB</name>
        <name evidence="11" type="ORF">MARINOS108_20504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="452"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="461"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="508"/>
            <end position="512"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="562"/>
            <end position="565"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="953" mass="104501" checksum="0AC2828BA50EA745" modified="2020-04-22" version="1">MAEEKTYRLSQVARKLNVGRGTILDYLSGKGFEVDSSPNSKITQEQYSLLSKEFASSAMEKEEASGLTIGNKHVDNMVIKDSQDSDKSEGDDEEEILIKDNNAKEAPKEKEKPAEPVEDDSDKVILRQKLEGPKVVGKIDLEPKKKAKVEETPEPPKEVEKKKEEEAPKVPEPVAEKPAPPVEEKPAPVEEKPKAEEKKPEPPVEVEKAKEEVKEAPKPAAPKVEEKKPEKPEEKTIAAKADSLKGLTVLGKIELPADKKKPKPVASSDERKDRKKRPRKRINSPAPNRQGRDNAALPPRGAPGSRGQKRDLRKTEELSDKEIQDKIKATLAKLSGGKSGSGTGRSKYRKDKRSAKAEAEEERLQAEQEDAKTLRVTEFISASDLASLMDVSVNEVISMCMSLGMFVSINQRLDAESITVIADEFGYDIEFTSEDDDTEIEEAEDSPEDLTDRAPIVTIMGHVDHGKTSLLDYIRDSKVTEGEAGGITQHIGAYDVMTETGKRIAFLDTPGHEAFTAMRARGAKITDIAIIVVAADDAVMPQTKEAINHAQVAGVPIVIAINKVDKPNANPDKIKEELSGINILVEDWGGKYQCQHVSAKTGEGIDELLEKVLLEAELLELKANADKPAVGSVIEATLDKGRGYVTTLMVQSGTMKVGDVVLAGSNFGKVKAMFDHRGKKLTNVGPSTPVLMLGLDGAPQAGDKFNVMESDREAREIATKREQIQREQSIRTKKHITLDEIGRRLAIGSFKELNVIVKGDVDGSIEALSDSLLKLSTEEVQVNIIHKAVGQISESDVLLASASDAVIIGFQVRPSSSARKVAENEEIEIRLYSIIYDAINDVKDAMEGMLEPTTEEVITGNIEVREVYKITKVGTVAGCYVTEGTVKRSNKVRLVRDGIVVHTGEINQLKRFKDDVAEVKQSYECGVSIKNFHDIKVGDIIEGFTEKEVKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J5</accession>
    <name>A0A654E4J5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIDA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIDA" evidence="1">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="520" mass="56983" checksum="044307D306B2805A" modified="2020-04-22" version="1">MREFDLVVSPEVGFDEDQLTTYLRQQGMLSAEEYFQIIRRSIDARQKQIKINLRVQTDTQPIDLEFVEYFQQAHQISGCPEVIIIGAGPAGLFAAIKAIENGLRPIVLERGKDVRTRRRDLAAINKDHVVNPESNYCFGEGGAGTYSDGKLYTRSKKRGSVRRVFEILVAHGAPREILVEAHPHIGTNKLPNIVTALRETIEAAGGQVLFDSKVTDLILESNEIKGVKLQDGSTIHGVATVLATGHSARDIFHLLHDKQIKIEAKPFALGVRVEHPQQLIDRIQYKCENRGEYLPASSYGVVAQTVLHKTERGVFSFCMCPGGFIVPSATAPGEVVVNGMSPSRRNSKYANSGIVVAVELEDIKAFHQFGPLAALEFQASVERQAWQLGGQTQQAPAQRLADFVNGKVSDSLNETSYQPGLASVNMDEVLPDFIAPRLRDGFKVFGKKMKGYLTNEAQIVGVESRTSSPVRIPRDKETLAHPEIKNLFPCGEGAGYAGGIASAAMDGEKVMAAVIASLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L4</accession>
    <name>A0A654E4L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase BoGH3B</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="696"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="783" mass="86748" checksum="DA81AE93702F05CC" modified="2020-04-22" version="1">MFRKYLLIVVVFSGILSCENPDSRLMEASFLTRPTPKIEALLAKMTLEEKVGQMAQVTLDVITKGESVYVSNEPLELDITLVKEAILDHKVGSILNTANNRARTPEQWNAIVSEIQDIAVNQSRLGIPVIYGIDAIHGTTYTAGATFVPQQIGLAATWNRDLVRRGAEITAYETRASGIPWNFSPVLDLGRDPRFPRMWETFGEDTYLASEMGKQMIKGYEGQKNDVSKPTKVASTLKHFLGYSVPYTGKDRTPAHISEMELRERHLPTFQAAVEAGAHSVMINSGIINGIPVHANREIITNLLKGELGFKGVVVTDWKDIDNLHFRDKVAATRKEAVKMAINAGIDMSMIPYDYDFCTYLVELVKEGEVSMERIDDAVRRILTLKDELGLFEQPVTSLADYPNFGSKDFELAAYDVASEAITLLKNDGILPLRKGSKILVTGPNAHSMRTLNGGWSYSWQGEKVEEFAGRYHTILEAIQSQAGASNVEFVEGVAYNHEGKYWEEEVKDLDAVIAAANGADYVVLCLGENSYTEKPGDLHDLSLSANQLNLAKAAASAGKPVILVLNEGRPRLISSIEGQMQGVLQTYLPGNYGGDALAAVLFGEVNPSGKLPYTYPMFGNTLVTYDHKPSEEQNKMEGMYDYESDFAVQYPFGFGLSYTEFDYSDMEFSRGSIDPDETLVISVSVTNVGNVEGKEVVQLYISDLFASVTPDVKRLRGFEKISLKPGETTRVSFEISARDVAFVAKDLSWTVEAGEYEVNIEELKSRFSITESKTFNQVKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E567</accession>
    <name>A0A654E567_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="71" mass="8302" checksum="1DDF145FFEFF5EAF" modified="2020-04-22" version="1">MKLQESKLTEVCKKEGIRKTQLAKEAEVSTRSVNRAEKTEKVPEEVTLYKILRGLNKLATRQYEFDEVFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E580</accession>
    <name>A0A654E580_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025025865" evidence="1">
        <location>
            <begin position="25"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="47"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="203"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="459" mass="51826" checksum="484D1C2C58F22777" modified="2020-04-22" version="1">MNKICKWTGVVLVSLMFGCNPQKAESPQDYSYQVPVDYYKLNNGLKVVFSQDKTAPTVVVAVYYNIGFRIEPQDRTGFAHLFEHMMFQGSENLGKMEFVKLVQQNGGVLNGSTRFDFTNYFEILPAHKLQTALWAEADRMSGLAITEDNLINQQGVVKNEVKVNVLNQPYGGFPWLDMPQYANENWYNAHNFYGDLEDLDAATLEDVKSFFDTFYAPNNAVLVVVGDFEKDETRQWIQEYFGDLPSAELPPVADISEPKQTAEKVFSKPDKLATRPALAFAYHMPERNTPEYYAMGLIDQLLLQGDDALLNQRFVKEKGYTGSVDGGINLLGNMFNYNGPMLWMGSLIHDAEVPSDSITAVLNQAIDEFTSKEVTQADLDRALIKMRSDLYSNLGGFFGFGRADLLASFALFDDDPGRINLLEGEFRKITPDLLKRTAEEYLVPENRTILILEPTTEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C7</accession>
    <name>A0A654E5C7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="5295" checksum="5A13F916AF584F65" modified="2020-04-22" version="1">MEKRAAHLKSQIFRLDQICISHQIRKFGRGEMTRLMEKMATCGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I7</accession>
    <name>A0A654E5I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="260"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="496" mass="54181" checksum="6E3E200A43391A9D" modified="2020-04-22" version="1">MYFLGLDIGSSSIKAALVDGATNKQVAVAQYPETEMDMISEQVGWAEQQPDVWWKNACAATQKALNSARIHPMEVAGIGISYQMHGLVLVDKDHEVLRPAIIWCDSRAVEIGEEAFQGIGEEKCHKHLLNAPGNFTASKLKWVRENEPELYAKIHKILLPGDYIALKLTGETTTTVSGLSEGIFWDFQNNEVAGFLMDHLGFDQEVIPRIVPTFGDQGRLSVTAAREIGLKPGIGIGYRAGDQPNNALALGVINPGEVAATGGTSGVVYGVKDKPVYDLKSRVNSFAHVNHTSEDPRIGVLLCINGAGIQYRYIKQMMAEEGLGYTDMERVMTRVPIGADQLRVIPFGNGAERILSNRNIGAQVNNLQFNRHKKEHFYRAALEGVAFSFIYGIEILKELGLDITKLRVGNDNLFQSGIFSKTIATLADAPIEMVETTGAVGAARGAAFAQGHFSSLAEAVSGDATINIYEPTTSEYQQYSNAYQAWVSDLKRLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5L7</accession>
    <name>A0A654E5L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="99" mass="11194" checksum="319ABDE93B3A5436" modified="2020-04-22" version="1">MGNETLRTEINNLERRVKLLLSEHAQLKVELQKVSNENQQLKAQASQQEANLANFQNQMKISKIVESMVVGDSDANEVKDVLDDYIKEIDKCIAHLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E690</accession>
    <name>A0A654E690_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="212" mass="24318" checksum="845427FB7AAC613A" modified="2020-04-22" version="1">MMEQRHITFQHTTPYGVLNELTENTRRIWLVFHGYGQLSRYFLRKFEGLNPEENYVIAPQGISKTYLEGFSGRVGASWMTSEDRLTEIANQKAYIDAVLRAHHIDWTDKRLVYFGFSQGVATMCRYAAHAKLPFEQMILWAGTFPPELERADFDFCDQNVSVKYFTGSNDPFYQAGMKEDQVSKVRAALGVEAEVRGFEGVHEVKADLINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6R4</accession>
    <name>A0A654E6R4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rnpA</name>
        <name evidence="7" type="ORF">MARINOS108_60160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="144" mass="16958" checksum="B0BA2DF3C5305785" modified="2020-04-22" version="1">MTDSGQTTSHAFSFPKREKLTGKKDIEELFKNGSSFYLHPLLLKYRREEDSAVTYHRALFTVPKKNFKRAVRRNQLKRRMREAYRLHKSIIYQSPVSGFYQLAFVYLDKSPLPYGEIEDKLKKLLVRLESQHSKIGKEHPGEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6W2</accession>
    <name>A0A654E6W2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13243" checksum="7CA988DD3B1B51CA" modified="2020-04-22" version="1">MTISFENIELLEVCEKEEHALKAFGEETSRRLFARISDLMSVEFVSEIPLGNPRTYGEATDQLMINIDENYVLVFGPAHPKNPYLENGQLDWSKIYRIKVLKIEKLNANSYLFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E704</accession>
    <name>A0A654E704_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="4">4.1.99.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">moaA</name>
        <name evidence="14" type="ORF">MARINOS108_11707</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="6"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD13953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="37034" checksum="8768B33D8EFE7C2B" modified="2020-04-22" version="1">MNITDTFGRKHNYLRISVTDRCNLRCFYCMPEEGIELTEKDHLMSLEEIIAIARQFTELGVDTIRLTGGEPLVRKNFAYLIEELSKLPVTLKLTTNGILLDKYFDLFERIGLKKINISLDSLDQAKALYMTKRDYFPRIMANIEEALKRGFQIKLNIVLIKGVNDAEIKDFVGLTRDKNINVKFIEFMPFKGNQWDWSKGVSEEEILKEVSHHFGEPQKQQDPAHSTSSNYQVPGFQGSFGVVSTITKPFCEGCNRIRLTADGKMKNCLFATAETDLLTPHRAQADLKPLIFEAIKGKKFSRDGMEVMEQSHYEENRSMISIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7M1</accession>
    <name>A0A654E7M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004062">
        <property type="term" value="F:aryl sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010262">
        <property type="entry name" value="Arylsulfotransferase_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05935">
        <property type="entry name" value="Arylsulfotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="495" mass="56197" checksum="36273498B3EC1C25" modified="2020-04-22" version="1">MLSRLYIFALALLILACARRGEEGVCFIPHEIGTIEIYQRPDNSLRVGIDVQTNPGKDVYVTYWEKCDSRLECNDKKYYSDLSSADTLHHLVLVVLKPATTYEFQVVVQDELCKTLSSTYEFTTNLLSPWVPYFPKPDSMKQVSFSGYVAFQARKDQGYLLMIDDTGELVWYQKAPMNVKVSKYTWKNTFLSILSDDTLRFSSGNHIAEVGLDGNVLFEVEKGEGAFNKTVHHEIDFDENGNIMSLTYEQEVVDLSSVGGGKQDIVRGDGILIYDPVKNEKVWEWSVFDVFSPLDYANILNERGDWLHANALVKDTLGNYLISFRNCSQIWKIDGVTGALIWRLGRGSEDLFLPEDFLFNGQHNIHFDTEGYLVILDNGNRHAQPGVRNANPDYPARSKPVSRMLTLHIDEETRKVDVVGEVVFPEVYMTESQGSAGRISDELVLFNSSTKNILSFVNSKGENLGSLLLEYPSYRAQYIPDLNHSKAYVNKFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E829</accession>
    <name>A0A654E829_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_12047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="207"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD14639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="413" mass="46972" checksum="930499C21BD31462" modified="2020-04-22" version="1">MWNEQTILIVLLVIITFDFVFERVITHLNNKSSKKPIPSELNGIYDNEKYAKSQAYQRATSQFGTLTATLSFVLMFAAIYFGWFGLLDKWLRGFSPFEPLTTLLFFGAVFIISDVFGTPFSWYQTFVIEEKFGFNKMTPKTFWLDKLKGYVLTLLIGCILLAALIYLVMAMGSGFWVYFWIIITVFILFLNVFYTSLLLPLFNKLTPLEEGSLKESIQAYSEQVKFPLKSIFVMDGSKRSSKGNAFFSGLGKKKKVVLFDTLIAQHTTEELTAVFAHEVGHFKKKHIILGTVISILTIGLMLFLLSKMIFNSEVSWAMGGDITTLHLNMLAFAILYTPVSRILGLFSNALSRKNEFEADEYAVTTYAGQPLIDGLKKLSSDHLSNLTPHPAYVFVHYSHPPLLERIRAMQQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAF4</accession>
    <name>A0A654EAF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine cyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="PTHR31270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024788739" evidence="1">
        <location>
            <begin position="23"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="355" mass="40165" checksum="E0E6FB1811734C9D" modified="2020-04-22" version="1">MKTTYTFIAFALALLISLFSCSGEKENAEASHGSPRIKKHSKLVAPKVNSEYLLGDAVDFSIESKETIDSIVLDYEGQAKTYQEPNFQWTADQAKTGTQKLRVTVYTNGTTETHYPKIRFFSDTQPEAYTYEVIRELPHDPEAYVQGLFFLDDTLVESTGREGLSRLSKTNLLTAEKYQTVNLSSQYFGEGSTVWENQIIQLTWTSQVGFVYNRALEQTNTFHYTHEGWGVTTLNNTLVVSDGTEVLHLLDPRDFSETGRLEVYTHDEKIVNLNELEIIDGLIYANVYMEDLIVVIDPKTGKVLRNIDMTGLSSQFNPREIDALNGIAHHAATGRTYVTGKLWPKLFEVTFKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDU6</accession>
    <name>A0A654EDU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ddeIM</name>
        <name evidence="9" type="ORF">MARINOS108_20787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="402" mass="45134" checksum="4ED17DBBE41520EB" modified="2020-04-22" version="1">MNISSLDLFAGAGGFTLGLKNSGITTIGANEIDRFAAETFRNNFPEVSLMETDIRELSNKTLKSHFSGVDLIVGGPPCQGFSVAGPSQYGILDDRNDLVLEFIRAISVLKPKMVIMENVKNFLNGKLPSKDLVVDVVKKKLKDLDYSVKIKVAYAPDYGIPQSRTRVFIIGIHNKADLQFPRIEPTHGFALDSYVKVEEAIYDLPFIDVNQGFEDSPELLEYREVELSDYQKKMRLNSPGIFNHVSMKHTPRLIERFKHIPQGGSLLDVPFEHGQRVRNGNSLDLKPRFKMNNQRLDPKNISQCITASFQSTFVHPVLNRNLTAREGARLQSFPDHFIFKGPRTLMSKKLLIREGREDEIGLSQYNQIGNSVPPLLAQAIGKSIIESFEQSKKQESLQTAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSJ2</accession>
    <name>A0A654DSJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ORF">MARINOS108_10064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="551" mass="62269" checksum="09C51232465E0F65" modified="2020-04-22" version="1">MLSTINPEESNSWKALTKHFDTIKETHMRTLFEQDPHRFETFSKTFEDILLDFSKNRINSKTFTLLCELAEEMGLQEAKKQMFGGEPINLTENRAVLHVALRNCGKKPYYVNGENITPAVMSVLDRMKSFTERLHQGDLKGYTGKRIEHIVNIGIGGSDLGPFMVTECLKPYQKAGIQSHFVSNVDSTHIVNVLKAVDPETTLFIIASKTFTTQETMTNALSAKKWFLDAAKDEKYVKDHFIAISTNKESVTQFGIDEANMFEFWDWVGGRYSLWSAIGMPIACAIGFDRFWELLEGAEAMDQHFLNTPHEDNLPTILALLGIWYNNFFGAETQAILPYDQYMHAFAPYLQQGDMESNGKYVGRNGQKVTYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFLAAAQSQNPLDDHHEKLLANFFAQTEALLMGKSREAVESEFKAGGADQETIDLLSPFKVFEGNRPTNSILYKKLTPRTLGSLIAMYEHKIFVQGIIWNIFSFDQWGVELGKQLAKAILPKLSGEESIHDHDASTSGLINAYKQLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSQ1</accession>
    <name>A0A654DSQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="15432" checksum="C0A5C0AEA9800402" modified="2020-04-22" version="1">MIPIQYIEEIKVSAGDLDELHHVNNVVYLKWVQLVAENHWRSAVSQTLQNQYIWVVLSHFIQYHKSAVLDDHLTLLTYVGEFEGVRSIRYVKIKRGTELIAEAKTEWCMLDAVTKRPKRVTDEVSQWFFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTH6</accession>
    <name>A0A654DTH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative OPT family oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004814">
        <property type="entry name" value="Oligopep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00733">
        <property type="entry name" value="TIGR00733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="670" mass="69988" checksum="7D6A1CB397D907E3" modified="2020-04-22" version="1">MSAVKTPQNPNYMHKPYISPETKLNELTFRSIIIGALLSVVLGAANAYFGLFSGLTVSASIPAAVISMAILKAFKNSNILENNMVQTAASAGESLAAGVIFTIPALVIMGYWEEFNYIETTLISICGGVLGVLFTIPLRNALIVKEKLMFPEGVATAEVLKTGQTGGKSVKYLIYGSLIGGLFKLGTEALKLWGGVYEKAALVNQKAYLYFSLNLSPALVAVGYIVGLNIATLVFLGGVITWWVAMPAYLSFNGYAQVAAELVEAGKFVSVDGISPEALGGALWSAKMRYLGVGAMIVGGLWALISLKSALTTAFTSGVKAFKAGAQNVSETLRTELDTPMSWVLMGIGIMIVPVFFIYLTIIQDVPVTLFMALIMVLAGFLFSAVAGYMAGLVGSSNNPISGVTIATILSTALLLLLLMGSSDPSRGAAGAILVGAVVCCAAAIAGDNMQDLKAGYVLGATPRNQQVMQMIGVVAGALLIAPVLNLLLASKGIGNPTAEHPNPLAAPQATLMMSVATGIFGGKLPWTIISVGGGIGALIIIADQYLKKIGSNFRMPVLAVAVGLYLPFELDSSIFVGGVIAWMLDRSFKRNNISSESADRASNAGLLIASGLITGEALMGIMIALIATFGLDLELSDGTFGGSLLGPGLLFLILVYLYRSVVKASKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTP5</accession>
    <name>A0A654DTP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025058927" evidence="1">
        <location>
            <begin position="26"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="314"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="581" mass="62061" checksum="FF66A535BCBDFF7B" modified="2020-04-22" version="1">MKKQMKNYIRNGWLLMSALTLVFLASCNEDEPEPKEVVASFQFELGETNFLEVTFTNFSQNATTYAWDFGDGETSNEENPVHSYAAADTYEVKLTATNDAGESATRTQSITLSDPDEELTKLAGVESKTWILQREGVVLGIGPAGGDTQWWSFGGVTPHGDRPCILDDEYTFNRADLSFDKNTNGTLFTDGTGNGGWNNTVPDVCNSESTVDWMSEGSIDMSAYKSGGDYTFELSSNTLTISGDGVYIGLANKTNAGDIGTAQSPQNKIVYSIIKLVDHDDVDSLQLAMQVDGGDVYWSFFLVHYDDASLMPPIPSAEPRAAFSSAAENLVVTFTNSSANATSYAWDFGDGGTSTDENPVHTYAEAGDYDVTLTAKDDNGLTSSVTQTVSVSAATYSSEIWASAEGKVWTLAPVAGAFRVGPAIGSGEWFASSADDATARACQYDDEFIFATDGSFTFDSKGAMYGEGFMGVDPAGCVNDGDIGGVYAGFVTSTGYTFATTDATDTDRASVTVTGTGAFLGFNKGYNGGEYNGSDAALQGATTYKIFSYFNDGTVERVDVAVDISAEQNGTAWWTMILEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU56</accession>
    <name>A0A654DU56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnA</name>
        <name evidence="4" type="ORF">MARINOS108_10612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="11852" checksum="8993E6CC92711273" modified="2020-04-22" version="1">MSEFPPCPACKSPYAYPSDTLLMCPECGHEWDPQAEAAADTSVIKDANGNVLEDGDTVVVIKDLPVKGAPKAIKAGTKVKNIRLTDGDHNIDCKIDGFGAMSLKSEFVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU68</accession>
    <name>A0A654DU68_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="27139" checksum="13172A76D3286239" modified="2020-04-22" version="1">MTWIEALILLGVGLFTGVINTLAGGGSLITLPLFIFMGLPSSEANATNRIGVFLQSLVAVGGFKSKGVSVFPYAFYVSITAVIGCIIGAYFAIDIKGPLFNKILAVVMVIVIILTVLKPYLAHKGTLEIFTPRRKLLTIVLFFFVGLYGGFIQAGVGFLIIATLTGVHGFNMAKTNSIKSFVIVCYTLVALGIFWWEDQIRWDYGLTLAAGNSAGGWIASRWSVGKDDKWIRLILIVTVVGLAIKLWFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUB6</accession>
    <name>A0A654DUB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ORF">MARINOS108_10219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="344" mass="38353" checksum="9867AC7AF1987B16" modified="2020-04-22" version="1">MATFIGIEYTTWWFLVVGAVFSGYAILDGFDLGAGAWHLFFKDDKSRRTALNAIGPVWDGNEVWLVIGGGALFAGFPIVYATLLSAMYIPFMLFLVLIIFRAISIEFRSKEPMKWWQNMWDGAYSFSSIMLAVLLGVVLGNVLQGMPIGPDLEFDGDWIAFFNPYAVMVGICTLALFMMHGAIYLIMKTEGKQFIKMTLHVKQAIIFFLVSFGITTLYTLIYFPHLSDRFKGEPVLFIVPLIAFLSIANIPRLISKKRYGNAFAFSCISIATLLIVVAIELFPVIILSNENPANSLTIHNASASEKSLGTLLIIAAIGTPLVVAYTTFVFWTFRGKVKMDELSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUC1</accession>
    <name>A0A654DUC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8472" checksum="FA52CD3D1BB31274" modified="2020-04-22" version="1">MNPSTHGELTLEVLQALEALKGKAQIHSHHEIHQILQQSIDHIQHTQHTPVAHKINFAERILGRLLHQWLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM8</accession>
    <name>A0A654DUM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022269">
        <property type="entry name" value="CHP03806_HNE0200"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03806">
        <property type="entry name" value="chp_HNE_0200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="361" mass="40413" checksum="C1EAB5519B6CEE23" modified="2020-04-22" version="1">MKIISLLLLVVVFMGCDSTPKKKVIEEVNLVGTVGLDQPEKLSDWGLFSRPLKELSPAAGVLPYDLNSPLFSDYAQKARFVKIQDGTMAIYDSMEVMNFPVGTILIKIFYYANDLRKTDGEPRIIETRLLIHESQGWNALTYVWNDEQSEAFLEIAGKTVPVSWTDESGILKRVNYSVPNLVQCKSCHERSGQMAPIGPSARQLNRDYTYEAGLANQLDHWAEAGILSGLPDTHHRPKLPVWDDERTGALDLRARAWLETNCAHCHRAEGPAKNTGLYLTYTETDSYKLGINKPPVAAGRGSGGLTYGIVPGQPDQSILVHRIESLDPGVMMPEVGRKMRHEEGIELIRQWITQMEAERHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN9</accession>
    <name>A0A654DUN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RND transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="84"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="335"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="50121" checksum="277F77E26B6D2855" modified="2020-04-22" version="1">MLKNKRVLIVGGASLFLLILFFILRGSGTGISSDIMVPVSVGEFIVDVNTTGELEAKNSTSIMGPSGLRNYRIYQVNIQNIIDEGTYVKKGQYIARLDPSELTTRVKDTQLEVEEKESQFIQTQLDTTLQMRESRDELINLEYAVEEKRLVLEQSQFEPPATIKQAEIEVNKAKRAFEQAKENYEIKRQQNVAKMQEVAANRKKVRLELQGMMDLQENFIITAPEDGMLIYRKGWDGKPIKEGSQISAWDPVVATLPDLSSMNSITYVNEVDIRRIAVGQKVDIGLDAFPDKRLTGLVKRVANVGEQRPNSDAKVFQVTIEIDKIDESLRPGMTTSNKIFTNVIPETIFIPLECLHNQEDSITYVYLKQGLGYIKQEVQVGETNANSAQILMGISEGQQLYLSIPNGGDEEVSLLPELNGKRGKKSEETPAVKAPEPEQGRKRKPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUS6</accession>
    <name>A0A654DUS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="22953" checksum="BC27AD83095037C2" modified="2020-04-22" version="1">MDELKQAWEEMTSDSKDLTQLSEAEIKGTTSVKSAGVIEKLRSGVKKKLAYAVFFTLAIGGGIPFAFPLASQILLTILFVAYLVGAVLLYQELQILNRGVDMTQDVLHGLTTYRDRIKRVLRYEESTALALYPVSISGGFFLGFQLVDREAQIMTQTIHWVFLVITILLFTIGGHWLARWMNRKAFGQYLDRLDETIEELRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT9</accession>
    <name>A0A654DUT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="21077" checksum="946757C14FB2D498" modified="2020-04-22" version="1">MKKLFFRFCFRLTGWKMKGQRPDLKQYVVIVAPHTSNWDFFVGVAARSISGLKSHFLAKKSLFDLPVVGWFMRAVGGFPVDRSRNTNMVDQVVELFQQHEEFIITITPEGTRSYVPEWKTGFYRIAHKAGVPIVMVGFDFEHRVVEYREPFYPTGDMEADLEFIKSYYRSIKGKHPEKGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU9</accession>
    <name>A0A654DUU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Por secretion system C-terminal sorting domain-containing protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028203">
        <property type="entry name" value="PSII_CF48-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14870">
        <property type="entry name" value="PSII_BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024882280" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="PSII_BNR" evidence="2">
        <location>
            <begin position="153"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1041" mass="112279" checksum="27A745CF17B37DC7" modified="2020-04-22" version="1">MKKSNLSICLLLLINTLLSAQWVPTGGPSGGNTYDIAQAGTSLVVAAGRGGVFKSVNNGVTWEPKNTTLPSNINAWRIKESNGLLYLITTFAIYISSDEGENWELSYSGIDSFSDLTIQDGTVYVYSHASSGVLYSEDNGANWVEKRAGNAEVKLRDLAFFNSAVYGGGQSLFRSSDNGDTWDAIEVEGLGPNGISSMTATEEVLYIADDGHVFSSHNGDEWVQTNIDLGGTILTMGISGDSVYLTTGDGMVFYTKDEGQNWTKIQNTKTNSIVNSVTFLEGKIVMCTSEGLFSSIDAGATWYESNYGMTAMPIESLAASESSLYVGTKGAGIFRSDLKGNWVQNNSGLSGSNALSIYDIIIVGDSVFLGSGGGVYAATIDGDSWTRLLDPGLNKSIQALHYDNGVFAAAVNGTGVYISNDKGNTWVLASNTGLNTDTSYESIYVQGDTIIVSNASLELFVSQDLGATWTDISIEEVYTTREVQIHQGRLYAGSDQGLYFSDDLGVTWVATAIGVYGIHGLVVGDGNLFVATNQGMFLGSDKRDEWYDVSDQLTNKSLTSLILAGDHFYAGTNGASVWQRNASEVNLPPIILEVNQTLIIEEDTPLELNLSHLSVDDDSDFPGNFTLTINDGENYSVSDAGILPDPNFNGLIHVDLTVNDGVNNSAPFWITIEVTPVNDIPVVTGTSSPTTTPEDTPLNYLGSNLLVEDPDNTFPNDFTIYIRPGDNYLISQNQIIPDLDFNGVLSVPIVVNDGIDSSEEFELQVNVTPVNDVPVINGNTNTYTTPEETGIQIPVTDFSIVDPDNAPEDFTLNIIIGENYTVSGNEILPNLDFNGILSVPITVNDGEDNSEIFNLSLEVTAVNDVPIITGINAALFTLKGTPVEIPLTNLLVEDPDNDFPNDFTLNVLPGDLYSVSGNTVLPSADFTGTLTVSVYVNDGTDDSEPFNISLEVFKALELESATSNTWEVYPNPTKDWLIIKSNNLSDAFQIKIYGMNGELIKGLEQITSVNHTIDLSSLQPGMYLLQILDGAKEHTVRFMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV3</accession>
    <name>A0A654DUV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase/lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="17129" checksum="4FAB32E3ADBDAE47" modified="2020-04-22" version="1">MKILAPLAENGRINPDASIRDSQSVIINAPIQKVWEVLIDMSRWPEWNGDIKSVKVDEVKDGAEFRWTLNGSTLTSTIRKVQAPELLSWTGSTKGIKAIQVWRLEDSGDNQTIVSTEESLQGFLTLFFSHQKLHTTLLKWLERLKQRVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV66</accession>
    <name>A0A654DV66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9285" checksum="0AEA39597E594C90" modified="2020-04-22" version="1">MAAEKIEKALVEAKDKLSQLGIEEQLVSEIEWCLGSYAHDQNAEGLYVKGAEAYTALEKFKKTNARKVSKKLLDDLEKAIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC5</accession>
    <name>A0A654DVC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine and CO dehydrogenase maturation factor, XdhC/CoxF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="207"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="43193" checksum="2A3AD0644D9CCF71" modified="2020-04-22" version="1">MKEVKHIIEAYEKIDFSARKVVLATVVRVAGSSYRNPGARMLIMDNGQWVGSISGGCLEGDAMRKARQVMRSQQPVLVTYDTMDDDHNELRIGLGCNGVVDVLLEPVAAPGESHSLDHLRGLLTLSSLGVAALVYHSDDHHIIPGERLLLLNDEGLNADYCSAALTDIIGEDLPSILTSKKSATRSYPVEGGTLEVLFEVVEPSIEVLIFGAGADAQPVVNLAKSLGWRVTISDECIAHLAPVHFPMADQLVSCQRGFVNREITVSPYTAIVLMSHNYDYDLEVLKQIVKSEAPYIGILGPKKRADKLFAALEAANISLTEQDLQRIHSPIGLDIGAETADEIALSILSEVLAKFAGRSGGFLKYHKGPIHKRQGVDDQVFKQVYLHSEHDQQQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL6</accession>
    <name>A0A654DVL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Rmd1/YagE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="1">
        <location>
            <begin position="47"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="263" mass="30473" checksum="8D17DE690DD1B0B0" modified="2020-04-22" version="1">MDDKILYTAYHIADRIDVANYRLLHPEHLITKSSLELYYQLDITRYVYIVSYGAVVFAGMTKPDIEEYLKLLKASSIRPKSSATSDDLEILLGEREDEITLSFDTLALGTFNHSVNKMIMMHLAQSVALDHFNGLSQSILSEIKAYTHDMQVYGKVKLSQKKAMSFIGKTLNTKNTIAENLYILDSPDVAWENEYLDRLHDTLVRHFELVPRYREIDNTLKIVEDNLTVYMSYNHHRESSRLEWIIIILIIIEVLDTFASKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVM4</accession>
    <name>A0A654DVM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppgK</name>
        <name evidence="1" type="ORF">MARINOS108_10773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.63" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047330">
        <property type="term" value="F:polyphosphate-glucose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="26464" checksum="FF95939B934CD003" modified="2020-04-22" version="1">MKILGIDIGGTGIKGGIVDTKKGELITERHRISTPDPATPAAIIETVIELVKEFDWQGPIGCGFPAAVRHDIVVTASNIDQSWIGMNAAKAIQKATGCPTHLVNDVDAAGMAEMKFGAGKDQKGVTLMVAAGTGIGTALFIGKHLVPNTELGFVHVKGMPGEHYAANSVRKSEDLSWQEWAERLNEYFKKLEFLFWPDLFILGGGVSKDFDSYKQYFTLDTQLVPAESRNHAGIIGAALAAKEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP9</accession>
    <name>A0A654DVP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="21997" checksum="A563BEBDD6D4E7A2" modified="2020-04-22" version="1">MADKIKLEILGLSSSQSQSGSFALVLGEVGGNRRLPIIIGMFEAQAIAIEIEEITPNRPMTHDLFKSFAFNLGYDIKEIYISDLKEGVFFAKIICESGGNQFEIDARPSDAIAIGLRFKVDIYTHESILTEAGIVLTDEEEEITEVKRKSTGSGKPEPVSKKLEDLPSDQLNSMLDEALAQEDYERAAKIRDEINKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT5</accession>
    <name>A0A654DVT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="38472" checksum="E8FE1F92B16F6E34" modified="2020-04-22" version="1">MARIIITLLFFVTLGITSLFIVASEGNLEKDQHFSTTQYDSKIKQFERSDTLSVVTFNIGYLSGMTNNLAVERVEELYHQNLSVALKTLERIEADMIGLQEVDFGSQRSFMYNQLDSLALQLDYPYAYRSVNWDKKFVPFPYWPLGHQFGKMLSGQAILSMFPVANAQTITLIKPINTSFVYNAFYIDRLVQVCDLVLAPGDTIRVMNLHLEAFDQETRLAQAETVKQLFESYSDQLPVLLIGDFNSPPEYLQPDDAMSVIMSAKHIRSAVDSLTYESSPASFNTFNSREPYQMIDYILYNENFITSVGQSVISETGEISDHLPLLMKFVLRGENDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU6</accession>
    <name>A0A654DVU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="75"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37359" checksum="B0D7ACF25A7F985C" modified="2020-04-22" version="1">MKRLLKILILPLILFLVYLLGPRPQFDELEGPNIKLMNISLDSLDRYVKAKDLDIPDLKADNASRIVWADSIRKTRYSVVYLHGFSASPMESNPTHLDFARQFGFNIYLPLLAGHGRNSVESFADLQPNDLIRDAKEAIAIGQLIGEDVIVMSCSTGSTLAIYLAGENKELIDALIMYSPNIALKDPTAKLVTGPWGRQIIQQVVGPYWNPNAPEEGGDGQKYWTRTYRTEGLIALQSLLDQTMTTEVFEKITQPYFLGYYYKNEAEQDGTISTDAIRSFVLQTATSETQKMVVPFPDAGEHVIANPLKGRSVQNVQDSTARFAEQILKLTGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU9</accession>
    <name>A0A654DVU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribulokinase</fullName>
            <ecNumber evidence="3">2.7.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araB</name>
        <name evidence="6" type="ORF">MARINOS108_11202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07781">
        <property type="entry name" value="FGGY_RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005929">
        <property type="entry name" value="Ribulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01234">
        <property type="entry name" value="L-ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="5">
        <location>
            <begin position="292"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="554" mass="60330" checksum="EAB6816812941FFE" modified="2020-04-22" version="1">MEKQYVIGLDFGTDSVRSVLVDSANGSTLGSQVHWYNRWREGLYCDPATNRFRQHPLDHIEGMEVTIREVVKETGVNPTSVKGICIDTTGSSPIPVDVSGTALSLLPGFEENPNAMMVLWKDHTAIAEAQEINTLARTWGGEDFTRFEGGIYSSEWFWAKILHISREDEAIKAAAHSWVEHCDLMTFLLTGASDLNGLKRSRCAAGHKAMWHERWGGLPADAFLAKLDPHMVTLKKHLYQDTYTSDKAAGKLSTEWAERLGLTTDVVIAVGTFDAHSGAVGAEVEENTLVRVMGTSTCDIIVSGKYVIGERTVKGICGQVDGSVLPGMVGLEAGQSAFGDVLAWFRDIVSWPIDQLIARSNLLTPEQIEQLKGDVIVELSRQAEQTPVSESAPVALDWVNGRRTPDANQSLKAAMVNLSLGTGAPHIFRALVEAICFGSKKIVKRFEEEGVTISTIVGIGGVAKKSGFVMQTLADVMNMPIKIAVSDQAPALGSAMYAAVAAGIYPSMKESVAAMGNGFEKTYHPRPDMVRIYEELYTKYEALGAFVETNINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX2</accession>
    <name>A0A654DVX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="416" mass="46499" checksum="9F20966D75DBE7CC" modified="2020-04-22" version="1">MRHFVLILFILCTHLSFGQMDSLRTYYQLSIEAYKAGEYGDFLRYTVRANEIRPNHPGLAYNLASAYAVNNRKEEAVSALSTFLRMNASLDYQKDSDFDSLRGYEPYEQLVEQVAQSTKKMTNAQVAFKLSQKENHYESMTYDAGSETFFIGTINTRRAMKYKSGAVEQLLGDEPLLYSIMGLDIDPETNILWICSAALPEMQGYSDTLQNRSSVFGLDLTTGKVKFSYLIPEATLGDLISMGNGTALASDGLGNKLYELRPDGFSVFADLSGTLLNLQGLSKSENQLYISDYLTGLYSLNLETKSLRKLRANDLYSEKGTDGLLSYQGHLIGFQNGTQPKRVTGVRFDAHKAVQIKLIEQNSSLKGEPTQGVISGNTLYYIATSAWDAYEDGKYQPDTAADLEIRTLDLVQFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWJ1</accession>
    <name>A0A654DWJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="175" mass="20048" checksum="B6A292C3FD060503" modified="2020-04-22" version="1">MEFKTTLSKFSGKDASVYELHLPVPKPIAEQFIRGENRRIICEINQTTSIRSGLMPHKDYWYILLNQAVIKKLGLAIGNTVTVKLSPDDSTYGMDMPEELIILLDQDPEGNEYFHQLTPGKQRNLIYIVSKVKSPESRLNKALAIVHHLKERNGKLDFKLLNVVIKDYNQRGKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK1</accession>
    <name>A0A654DWK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024787069" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="20846" checksum="D9B1A2B14F4674BA" modified="2020-04-22" version="1">MKRISIGILFLIVSYLAVAQENEQTSLGATIDKLSYDWDLEADNLNSYDGLSKFCLDKDYRIGVIQLLNDIHHYDSVLYDRLTKASRFNKDKEIDKTLKEISKFEEGYSLKDFIHFLHEECTTRSDIEKHSAESRNDIGSNSYDGQVYIVETELNKFIKHITKRVDHIREHVHHLHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX2</accession>
    <name>A0A654DWX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="8151" checksum="34DA9332C775131C" modified="2020-04-22" version="1">MESIRIDILNPKAKKLLQDLADLNLIAFQSNEESNFSTFLERIRSKSDSELSLEEISLEVKRVRKSRNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY4</accession>
    <name>A0A654DWY4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025061282" evidence="7">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="67"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="271" mass="29339" checksum="4732A097FF62DCF1" modified="2020-04-22" version="1">MKTMRILSRVLVLALLPFSMACDKNGDVSFFSIEQDKELGAQVAAQIASDTSFNILSAAEYPEAYAYLESMKNVILNSGSVSYKDEFAWKLHIIYDDVLNAFATPGGYIYVYTGLIKYLEKADDLAGVMGHEIAHADQRHSSKQLQKAYGVQILLSIALGEDASQLAQVAGQIAGTGAILAFSRSAETEADDFSVQYLSDTDYACNGAASFFQKLLDEGQGGSTPAFLSTHPSPDNRVADINAKADKLGCDTDTITESGFTYQDFKNSLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ7</accession>
    <name>A0A654DWZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009325">
        <property type="entry name" value="DUF983"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06170">
        <property type="entry name" value="DUF983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14436" checksum="7F6B47B87E137FE4" modified="2020-04-22" version="1">MAKKGPLKAIIEGKCPRCREGNMFLYPISNLRKFGAMHENCPHCGHRFEQEPGFYYGAMYVSYALSVGIFLATVFVLYVFVGDPSLETYIISISAVALLLYPFTFRYSRIIFTYVFGGVTYDPKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX06</accession>
    <name>A0A654DX06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alternative cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">coxN</name>
        <name evidence="9" type="ORF">MARINOS108_10915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="618" mass="69084" checksum="A373FBA7EA4C5263" modified="2020-04-22" version="1">MSVADIQVEEHLAHDDHEHHEQSFISKYIFSTDHKTIAKQFLITGIFWAIIGGALSIIFRLQLGFPEMQLDWLRPILGKWITEGGKLDSEFYLALVTMHGTIMVFFVLTAGLSGTFSNFLIPLQIGARDMASGFMNMLSYWFFFLSGLVMFISLFLETGPAAGGWTVYPPLSALPQAIQGSGAGMTMWLVAMVFFIVSTLLGGINYITTVINMRTEGMSFSRLPLTIWAFFITAVIGLLSFPVLVAAALLLVFDRSFGTSFYLSEIYINGEALPNVGGSPILYQHLFWFLGHPEVYIVILPALGITSEIISTNSRKPIFGYRAMIGSILAIAFLSFIVWAHHMFVTGLNPFLGSIFMFLTLIIAVPSAVKAFNYITTLWKGNIVFTPAMLFSIGLVSFFISGGLTGLFLGNSAVDISLHDTYFVVAHFHLVMGSASFFGLLAGVYHWFPKMFGRMMDNRLGFIHFWMTFVGVYLVFFPLHYIGIAGFPRRYYSFTSFDAFSSFADLNSFVSVAAIVTFGAQFIFLFNFFYSMYRGRRAPQNPWKSNTLEWTTPVEPGHGNWPGAIPKVYRWPYDYSKPGAAEDFIPQHIPFSQTPESNLPHESEAAKTEGSAQVNETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB2</accession>
    <name>A0A654DXB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="32909" checksum="376613942D8F48BD" modified="2020-04-22" version="1">MSTSGQTYKELALPYFKEVFDIIDKVLVKEDIPYYLIGATAIALEFLNEGKKPPRGTRDIDFALMLSSMAEYDHIVSDLKEYGFNSVEAPWTLYHEKYDVAIDLLPFGKIEENDTESFNKRYSDLHVLGLREVLEDAIEILIEDKVAKIPPLAGMIILKLVAWSDRPEERDNDLTDILKIIELSYEHDWDDIVESHFDLLDQLDETAGQLKISARVLGRKAREYLLKSETLSNRILSLMEEQLSNADSSGIARQWALSKDIDLELAMAILKEFETGLKEDGGLFWIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH9</accession>
    <name>A0A654DXH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="62" mass="6975" checksum="04D9DA9984C7EF2D" modified="2020-04-22" version="1">MMCKPCQQAIDTICGVRQYSLINIMGVNPQIKGTLIYYLLTDILPWVFLEGTGPKLIDAMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ1</accession>
    <name>A0A654DXJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="20847" checksum="319231D861C5E0D9" modified="2020-04-22" version="1">MNPYQTIWLNPKRTFEDFVVKNETQSLFVAPIIILGFIFGLNMTPDINAIIDDEFVWWSLLITMPAGIGIAFLVFGFLMPGLVKLVGRIWKGESTMRQMVNVYSISSIPYGLLLIYQLLLFVSGEDPLVEKVNAGYSYILWLWSFALLIIGISKIQRFSYKMALLNILLSYLPIIIIGILRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ5</accession>
    <name>A0A654DXJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="62" mass="6932" checksum="D604517C595119E1" modified="2020-04-22" version="1">MAATSSQECALLSASSDKTNEFAAPGKGVLTKYQNRTAFRKRKILRDAPNRKQYHFPAADSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ9</accession>
    <name>A0A654DXJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="205"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="393" mass="44998" checksum="2ABC6329AC5E79BF" modified="2020-04-22" version="1">MEILVISHKYPPSIGGMQTHCFKLIQELEKNHTIHPVIWKSNYPRGLFFLTVIFRVLIRLKRNPQIKCIYVNDGLMALICTPLLFLTSVPMYVTIHGLDVTFPSKFYQGWIRKYLNQYHKIITVSGPTTDLCLKKGVKPEKLTLIENAVDINFQEEPENPNFRSEFGHEIGANLEGKFLICSLGRAIPRKGFNWFTRNVYPSLPENAVYLVIARKFPQEKLFRWIQRLTPGRLFEKIRLLVGAEIDDTAVNDSIREMKLEGRVFYLSQFTHSRAKIFEIIKHCDLFVMPNIEVPGDYEGFGLVALEAASQGTLTLAANVDGIPSAVKNGINGYLIEGGNASEWSLKIRYFMDHPEELKASAQEFKTNTMTKGRSWDTMARRYAEVFSETPEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXM9</accession>
    <name>A0A654DXM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6540" checksum="E16902993CDD9EC3" modified="2020-04-22" version="1">MASNIRPTTTNGCYRPRNQPNVTDFNPTIIRKLDCSPESYRDYKSTSWHRPLQIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW1</accession>
    <name>A0A654DXW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="24389" checksum="D1E01924FF36A838" modified="2020-04-22" version="1">MKIFSLFKSGALLSTILLGACSKDDPSPGITIPIQTVVQSGISMGGTSSLALLAGESVTNTGATSINGDIGLSPGTSIDGFPPGEFTGTLHVNDAIANQAKLDLTTAYNDAAGRTSTDIVVLSGNIGGLTLTPGLYKSTSSLAISSGDLTFDAKGNANAVFIIQIASALTTTSGRQVILAGGAKAANIFWQVGSSATFGTTTVFKGTVMAMQSITFNTGATLDGKALARTGSITMEGNAIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY64</accession>
    <name>A0A654DY64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5380" checksum="27A3224EDA4F440C" modified="2020-04-22" version="1">MLTLRNSPKIHSPMNRFNKTAAIRVIDILIGTMIILTIVITFLEKGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY83</accession>
    <name>A0A654DY83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="65" mass="7911" checksum="99C2D4B29F7F0EBD" modified="2020-04-22" version="1">MDWKVRHVYATRSFKFKSRRGYVRDERLVLSNPTHHSWLLWRIATESKFQSGITKLNKLIHASYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY97</accession>
    <name>A0A654DY97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein TonB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_11661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024959506" evidence="9">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD13813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15944" checksum="E99DBAA859B96FCF" modified="2020-04-22" version="1">MKHILLLFAFVAFVATAVQSQIPVELFELLDDKDTTNLYFGADKNPEFPGGYEKLVRFYQNNLYYPTSARIDGSEGTVYVMFIVELNGKLTNIKATNSISKDIDKSAERLIKRMPKWIPGEQDGNPVRVLHVQPVTYKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA5</accession>
    <name>A0A654DYA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="31524" checksum="85326D65FB7161D7" modified="2020-04-22" version="1">MNTQDHINFQRIAEAIDYIQANFRDQPNLDEVAEQVHLSPFHFQRLFTEWAGVSPKKFLQYISIAHARSLLKDGQATLSEATHQTGLSGTGRLHDLFINIEGMTPAEYKNGGKNLKINYSYADSLFGNILVASTAKGICYLAFADDPSLAFSELKSKFPNASYEQRLDLIQQNALFIFTHDWTQLDQIKLHLKGTDFQLKVWESLIRIPSGRLSTYGQIASAIDKPTASRAVGTAIGDNPVAYLIPCHRVIQSTGRFGQYHWGSSRKTAMIGWEAAQITER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC1</accession>
    <name>A0A654DYC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="106"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="233"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="421"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="633" mass="72126" checksum="6B6751A51185F77F" modified="2020-04-22" version="1">MNISLINAELQPLARLFDLLSNHQPDQSFIIYGIKKEDLKSLNSFIDSLQFLKAKSLGERQLIAPGEVFLVQQKTAFYMDGQYIGAREHTESSHEKHRVDLTSQEDAARHKYLLEVSRELICTHDPGGAYKFVSPSVHKLLGYDPEELIGKDPYTYFHPDDIAHVVKTSHDLALKGLQPHRVQYRFLHKNGTYIWLDTYTEVIKNDMGGISSLITVSRDINDLKEAEIRLRESDQRFRAIANNIPGVVYLCRNDETYSMLYLNLEVMNLTGYTPDEFIQNQISFVDLYHPDDKETIFAKVDSALEHKEPFHITYRLKNKHSEDWVWVDEYGQGIYEGDELRLIEGVLLDITERKLVEYQLERYTENLEHVVAERTRELKVKNEALVKGNSELEQALKELKSTQSQLIQAEKMASLGILAAGIGHEINNPLNFIKNGCSGLIQELEEHPEYDEELLKPFLEIIDDGVTRASEIVKSLTHFSRQVKSMEERCVIHDVIDHCVVMLQSNLKHKVEIVKDYAPEELVVIGNEGKLHQAFLNILVNAEQSIQEQGSIVIRTARQEHGIVVSFEDDGEGIAEENLSRIGDPFFTTKAPGAGTGLGLFITYTLIKELNGEVQVESELKKGSKFTITFSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM1</accession>
    <name>A0A654DYM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional repressor for pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="27094" checksum="1BF9F180E6ACD319" modified="2020-04-22" version="1">MDLLNNFKEIVIEKPGDKIIKQIKELISSGQLKPGDRLPAERMLSERFGVGRTYVRDAIRKLEFYGILKTLPQSGTVVAGFGIGALEGLISDVLELQGSDFHALVETRVLLEVNAARFAAMRRTNEDIGSIASALSDYEKVVSEGKNSVECDLLFHLKIAEASKNSVLTSLMLIITPDILTYFKENNVCGGDRPVTALDEHYKILEHIEQKRPDEAADSMKEHLSDILSFSLTQSNISESAVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU3</accession>
    <name>A0A654DYU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="31569" checksum="3612881AFD2B5B44" modified="2020-04-22" version="1">MLWGIDLGGTKIEGVVLNESHEVLARERVPTEAVKGLEHIIGQITKLLDILAEQVGERPTKLGIGTPGSVDPQTGLLKNSNTQAINNQPFLQLLQEALNIPINIANDANCFALAETEMGAVHEQYPEAKVIFGVIMGTGTGGGIVINGKVLNGRQGIGGEWGHTFLDLSGGDCYCGDKGCAERILAGPSLERYYFEQSGNKRPLKDIYADYKAGIDPIAQKTIDRLIHFFGLGLSNVVNVLDPDVIVIGGGVSNLDVLFNEAVDSLKKHVFNPSFNTPIIKPKLGDSAGVFGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV5</accession>
    <name>A0A654DYV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="65" mass="7554" checksum="8D73BA4DC666231F" modified="2020-04-22" version="1">MIPSEFERYEQMEKEQLPVPKHKLHKWTHFAGLYAAEHVAATEFVIGATFISYDHPKVATHLAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX5</accession>
    <name>A0A654DYX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="859"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1393" mass="159028" checksum="D1ED072AB827398E" modified="2020-04-22" version="1">MVTIDLVISGINKVLQQMLLAFGMGLFVLELGAQPDINRIHTLDQPVTDVSDLIQDEAGFIWIATYEGVIKYDGYTLMPFHPVNEPDLHLRIQGIEEIVRSSSGHLWIAHQRGVSCIDLSSSKYVLFQGVDGSSTYSLLQNKWAYRLTEDQGGDIWVGTLEEGLTKISWSHNLEDRPLLSTYFENSTIESLKTSEDALWVSIKDLGVYRMASDDVFRHIWPIRKESADVKIRYSDIEVDQKTKSVWLTSWEDGLSRLQMDTKFSEVLQFHNWKAQDSQPSAFYKAVRTSDGIIWIASYGLGLYNFDPTTETFQNFQYNRDSKNSIPNDIIISLFKDRQENIWLGTFGNDIAVVHPGRNQFMRPTLLDDEADMKSQKSVVSIVETHNQTIWLATSRRGVYRSTYLPKSGVREEFEKVRELSGLGPVDFLFKDSRDNLWINISVKGWYKYDTREGHLSKITWIENQSVDRIADAIETPDGNFWMATRTNGLLKINNQEKTTKRYRNIEGDSSSLNSNAVYCLFSDSSGRLWVGTNNGIAVKNIGVDSFVRLQHDPDNDHSLSHNEVNQIVESDGVIWVATMRGLNKISYSSPLGADRFLIYDQTDGLADDNIKSIIAADNGQIWMGTKYGISCLQKQTERFYNFDLTNNLQSYSFNPRSILKDREGFIYFGSILGLNIIHPDSITFSETNFPVRLTQFRLLNQTVSHGEVIAGRVLLADDISQTERIELASDENSISFRFSTLNYKSNHIDHFQYKLEGFDKQWIKTNSNEASYTNLDPGTYRFLVKKESQTRNNGAEVEVIILPHFLQSTEARIIYILALIGILYLIHRIIKSNNELKIAKIEKAKEHELTQTKLRFFTNISHELRTPLTLIKGYLDELVVAKATDVRWGSPLNAIYQNTQKLLMLINQLLDFRKIENDSLGVSVSKVDVNEQIDEVINFFRYSAERQSKKIEFHSDFSGQYCWYDEDKLEKILFNLISNALKFSDSGGTVRVTLLVTDNKGHLGNKEIKKVMILEVKDTGRGIDKANLEGIFRRFYQVNSEGEEHFQGSGIGLAFTQRLVEIQQGMISVESELGQGTTFRVVLPASKDHIADYIPDENMELTEGNQHRELNGWPDLLETEVHENDPGDVELVFTVLIVEDNAEVLTLLKRVFNTDYRVFMAKNGQEGLELARELQPDIVISDVVMPIMGGYELCRQLKSNYITSHIPIILLSAKTSDEHQVEGFEFGADAYMTKPFNGEVLKSHIKSIITSRKVLRDRFAMEPHVEPKDITVNSEDERFLRQAIDLVESNLRNESFTTEMLADQLNMSRTVLFRKMKNLTGCSANAFIKKIRMKQAAYLIEKNFGNLTQICYEVGLNDVKHFRNSFKEHFGVTPSDYKAGIKPPDGITSKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ26</accession>
    <name>A0A654DZ26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase A-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024796545" evidence="5">
        <location>
            <begin position="32"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="530" mass="58955" checksum="607EBAEB53CD55DF" modified="2020-04-22" version="1">MKTRYMQSNARLPGSILLVLTMLFSSCQQEAQRSPNIVIILADDLGYGDISSYNPQSKIQTPAIDDLARQGVMFTDAHTNSSVCTPTRYGLLTGRYSWRTRLKESVLYGYDKALIPADRLTIAGLLQQQGYETAAIGKWHLGWNWANVDAGKDSIDYAQPITNGPTTAGFDYFYGIIGSLSMPPYVWVENDLPTMVPTRRTSSQKKQSIWLEGEIAEDFVHEEVLPEIQKEAVEYIHAHANKDKPFFLYLPLTSPHNPILPSPEYQGKSGLDNPYPDFVMMTDGVVSAVANALKEQGVFDNTILVFLSDNGCSNQADFEQLASKDHFPSYIYRGFKSDLYEGGHRVPFVVTWPDKLKPAKTDALVSTTDFLATFADLFSTSFPDNAGEDSYSFVSALGLTSEAPRRESIVMHSYDGSFAYRSGNYKALFTSGSGGWSFPRSGSDDVVGMPEVQLYDLKADPSEKTNIQSENPQLVNQLSKELTEIVRNGRSIPGLPQKNDGPENWKQLTWMNRENELPSTTGAGRENKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ77</accession>
    <name>A0A654DZ77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14251">
        <property type="entry name" value="PL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039513">
        <property type="entry name" value="PL-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14592">
        <property type="entry name" value="Chondroitinas_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="2">
        <location>
            <begin position="469"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="547"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="628" mass="68714" checksum="584B81194B0F3AAD" modified="2020-04-22" version="1">MRIAAFLVILLVAEVTLAQTRYNVSSLSEFKSALSEAVNGDSVVWRSGRYEDVFMDINVEGLVVTAESYGAVIFTGESKVEIDADKVVLSGFQFVGGDIGTDNVIRNWGSDVLITQINILGYTSFKYLIVDEDSRRTTISHCNFESRINLADQNILSILVDNEPGYHKIQHCSFRNFRGSGGDMGVEPIRIGVSSQAHLDSRTIVEYCYFENCDGDGELISNKAAQNVFRYNTFENNTKGELVLRHGDEAIVYGNFFLNNMGGVRVREGQNHFIYNNYFSGLTSRAIYLQNESSDPLDSIHVYFNTIVDSEEVKLGGSGSYPPQHVVFANNIFSNPKGVIFDDPTGTEQWLGNLSSGSLGIDRPSGISDLDPKLIENDEGFFQLDSGSPAIDAAVSGFPPIPMIDGLEFDDLKLDIMKQTRPDEIDQKDVGASEFPHTVGVQPYATTSNTGPAYSNDESIFSLSSSVVGEGSVAWSPVKDTYRLGEIITLTATPADGYQFSKWAGDLDGTDNPMMISITEDMNVIAEFALPVTPPPLGTGSRGAIEIFPNPTSDLVRLVLPSGSPPQLSLLVYDVEGKIRLSGQMTVVQDYLEVDVSMLPAAIYFLTLRNARNGEVVEEAGILRLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP1</accession>
    <name>A0A654DZP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HGSNAT_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="HGSNAT_cat" evidence="2">
        <location>
            <begin position="9"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="392" mass="44848" checksum="B72B6C1226E56EAF" modified="2020-04-22" version="1">MTATPIHSRITSIDLLRGVVIVLMALDHVRDYFHYDAFFYDPTDLTQTNGAIFFTRFITHFCAPVFVFLAGTSAFLVGERRGKKVLSGWLIKRGAWLIIAEITIIKLGWFFQLDFSLIVLQVIWVLGISMVFLAGIIHLPRKLTIALCLLVVFGHDAFNSFQPSESWSGVWSFLHVFSIVPVGSVAIFVGYPMIPWIFVMPLGYYLGQLYTPGTDPEYRIAKLRQIGLGAFLLFVIIRFTNLYGDPVIWTVQKNLGLTIMSFFNVSKYPPSLLYLLVTLGPAIYLLSLAERWKGTLASYMVTVGRVPMFYYIIHIYIIHIGGAIAAMLTGFSFSDMVINVWVTEEPQLDGYGFGLWVVYALWLLLIVGLYPVCKWYYQYKQNHRNQWWLSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR6</accession>
    <name>A0A654DZR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="35598" checksum="A490DBACAF725518" modified="2020-04-22" version="1">MKAIVVRANGQKYQLEFSEVSDPVLKPGHCLVRIKAAALNRRDYWISVGKYPGIKDGVVLGSDGCGEVIAGEPAWMGKTVLINPNINWGDNPEHQSSQYSILGTPENGTFAEYLMVPTDRLIEKPYYLSDTEAAAFPLAALTAYRAVFRKANVQRNQKVLVTGVGGGVSQFACAFALAVGAEVYVTSSSDDKLTRMMRMGASGGFNYTDAGWVKEAGGKVNKFDAIIDSAGGNAINDYLRLIQPGGRIVVYGSTTGKTEGLDLFRLFWSQASIVGSTMGNDEEFASMVDFITSHQIKPIVDSVHPFAEGVEAIRQTGSSSQFGKVVLEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU8</accession>
    <name>A0A654DZU8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">argC</name>
        <name evidence="7" type="ORF">MARINOS108_110061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD15892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="35022" checksum="4C3A3EB8705570A4" modified="2020-04-22" version="1">MSKIRVGIYGAAGYTAGELMRLLVHHPNAEVVCAQSESQVAKKVTEIHTDLIGDTNLVFSAHLDYRNLDVLFLCKGHGESRVFLAGNPAPDTVKIIDLSNDFRLKDDADGFVYGLPELNGPAIPKATMIANPGCFATCIQVGLLPAAQAGIIQSEIHTTGITGSTGAGQSLSPTSHFSWRNQNMSVYKAFTHQHLDEIGESLTQLAGKSHVVNFIPFRGNFTRGIIATSYFETDASEAEAYALYEAFYKDQPFTHVTNRNPDLKMVVNTNKAVVYLKKEGNKLLAISMIDNLLKGASGQAVQNMNLIFGLEETAGLNLKPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV9</accession>
    <name>A0A654DZV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YHYH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025924">
        <property type="entry name" value="YHYH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14240">
        <property type="entry name" value="YHYH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025041339" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="YHYH" evidence="3">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="YHYH" evidence="3">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="31786" checksum="8FB2AFB2B70B6BEF" modified="2020-04-22" version="1">MSVRDLMKQLAMLLLMGFLTFTVACDESPVDEPDPEEQLEEEEEEEENKEEEEEEEEEEEETKVDISILASKFYHTSAVSVTVTDDHVIISSSDQPDHKSMYYSPNNSLYEDYDEPNNPDFKKNPNSIEIQNFVYTLPRFPEEATNKEATDFGPMGVAVNSVAFYNQNAGPGDDILEELNTFDQYEGHPAQSGDYHYHLEPIWLTETISDDAFLGLLLDGFPVYGPVEGGKRLTNADLDDYHGHISATAEFPDGIYHYHITDELPWINGDGYFGTPGTITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E027</accession>
    <name>A0A654E027_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_110096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="449"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="699"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="844"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD15935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="943" mass="106771" checksum="B714D4CD38ECF3F4" modified="2020-04-22" version="1">MRIYLCALFVALIILPLRSQNIDSLTHELNRSEGSVRMDLLFQLSEAYMYQDWEMSLQYAREAAKLVEEEKDSKRAFESAYVLSRALEGLGNYAEALTYGKLAEELAQNDVDKANILHHLGHTYESLSEFQSALDYQLKSIELRKKNGDLKKLANAYNSLAFVYKGMSLYDRAIVTLQESLSISKGLGDAMGVSKATFNIGLMTMEMNRHAEAIPFFKKAMAGLNEEDFPHQFSYYYNNMANCFEKQLHINAAFYDSALIYGKKSLAIKKRLNNLRGVANSHNTLAATYERASDYKNSYYHATEALRLSDSLDFKPIKRNALSYLITAELGLGKTEFTNDHFEEYIDVVEEINEASYSRTLSEMAFKYETDKKEAENLLLRTEAEQHRLVNILLIILATVLVAGLVLLFYFFRLKQRTNQKLSADKKLIEEQAEKLSELNDLKSQFFANVSHELRTPLTLIQGHAEDAMNVKKLPAQASEPLKKIKRNVHQLAVMVNDLLDLSKIELRQKLVTVKPVDVDGLLKRICGAFSSLAESRQISLAYTSNQHEVTAAMLDEAQFEKVINNLIYNAFKFTPAGGSVKVIMTRVLEGIEVTVADDGTGIKPEELPYVFDRFYQAKDQMSTSFGSGMGLAISKELIDMMGGQLSVTSELGKGSTFRMILQPTDETPDALVGDSHQPEVVSSGDPRLDTLEIPSDTSVMVVEDNPDIRTYLATILRDHFQIMMAEHGQDALDQLERESPDLILTDVMMPVMNGWEFIEALQEKPALAKIPIIVLTAVAENQERIKGLRMGVDDYILKPFEAEELLIRISNVVKNLRERIKWAKEFEEEDEKVQLGDQHDLVLNIREYVKEHVAEKSLNVLQVAMHLGLSERQLYRKTAEAVGMSPSKLIQEIKLQHARELLISNRFDKLSQIAGAVGFDSTSHFSKLYLERFGKKPIDYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E079</accession>
    <name>A0A654E079_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="1">BCAT</shortName>
            <ecNumber evidence="1">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">ilvE</name>
        <name evidence="2" type="ORF">MARINOS108_12004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="33584" checksum="254B5B4A226AE295" modified="2020-04-22" version="1">MYYDDRTEVFLDGEWIKAKDAKASLFDQTLHYGTGVFDGLRSYNNGNGFNIFKPAEHFKRLHKAAEKVFLKIPYPIEDLIKIAYDLIDRNNLTNAYIRPLVFAGPNMILAPSKESHFFMTAWKWAKYPGYEPLNTMISSYLKPSPKSTVVDAKIVGNYSANTLASAEAKRLGYDEAILLDHNGHLAEGPGSNIFYEKNGELFTPKLGNIFPGITRSTVLEICEELKVKVTEKDITPEEFYKADHAFFCGTATEITHISSVNGEKFKKEWEGSIGHNLHLIYQQKVMFDEYQGLTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G2</accession>
    <name>A0A654E0G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13908" checksum="78B9C7037906C4EA" modified="2020-04-22" version="1">MNFSSIENDFAQFHIRDGVMFFTYKPDIEIDLDGAKRIVADRLKLQGEETYPVVCDIRGLKGANKAARDYLANEGSEKVKVVALIVASPGLKIMTDFYLMVNKPTVPTKIFTSEDQAVKFIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K1</accession>
    <name>A0A654E0K1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ORF">MARINOS108_120476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="8257" checksum="375E6F0DD4BDCD4F" modified="2020-04-22" version="1">MAKQSSIEQDGTIVEALSNAMFRVELENGHQLIAHISGKMRMNYIKILPGDKVKLEMSPYDLTKGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K3</accession>
    <name>A0A654E0K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="18566" checksum="D85F0A183B56292D" modified="2020-04-22" version="1">MSGKTKQWLLLGLVALIWGLIMVRLFDLTSQPEETLSPIRLSAKDLAKTTDETYRFYLNYPDPFLKDLSTPAVKELAPVENTERPMSKAIPQVVFRGTVSGTRVTTGMLMLNMMPRMVKKGDSFEEFKVLEVNDGEIKLYYQPLDSVLVVSKADQSEIFKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E134</accession>
    <name>A0A654E134_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfur relay protein DsrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_110124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DsrC/TusE family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042072">
        <property type="entry name" value="DsrC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025526">
        <property type="entry name" value="DsrC-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043163">
        <property type="entry name" value="DsrC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007453">
        <property type="entry name" value="DsrC/TusE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37010">
        <property type="entry name" value="PTHR37010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04358">
        <property type="entry name" value="DsrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006223">
        <property type="entry name" value="DsrC_TusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69721">
        <property type="entry name" value="SSF69721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03342">
        <property type="entry name" value="dsrC_tusE_dsvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006223-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD15978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="102" mass="11455" checksum="2748ECBF3A9F2364" modified="2020-04-22" version="1">METIIANMPVNVNEQGYLLDMNQWNKAIARQIASEEEIDLADRHWEVLEYLRAEQLKGTALSIRKIGKSGVVDIAEFYKLFPEGPLKKASRIAGIPKPASCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A8</accession>
    <name>A0A654E1A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative toxin-antitoxin system toxin component, PIN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="14885" checksum="A0E1CBAF0593F4A9" modified="2020-04-22" version="1">MKVFADTNFLISAFATRGLSADVLSLVITSHELIMSKLVLQELGEKLSSKLKLPRADILEIEAFLRTFTIIDPKEKSTYQLRDPDDEWILAAALEAKVDVLITGDRDLLDEANSIPELKILTPRGFWELLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I7</accession>
    <name>A0A654E1I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="41222" checksum="43F03D4B29C53B11" modified="2020-04-22" version="1">MEGRLFYAMKILFTTCQGGVAGSTHSIYYLVRGLARKGHEVHLACRRGSLLWDLVQRLGSVECHDVPFASYLDLASVRAVGRIVRKHQIDLINAQGGKDRNLTILAKWAFALDVKIVFTRRQRPRNEPWIKRWFHTAGTSGIVMVSKGLRDIFLAKGYNEAHLKVIFNGVPEDLLLNVKKENVEELRRVHGLTGKIICCISRKKLQGEIISALKYLPEDYSILFVGINEGDFAEWLASESPKQRILFTGVVSHEEALHYLQLAHVNVLPSHMDGFGLALVEAMLSRVPVIGSRFGGIPDIIQDGVNGFLFDNGDSRDLAVKIQRLAEDEILREQFVNRAYKDAIEKFLVERTVTEYEAYFTELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P2</accession>
    <name>A0A654E1P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biopolymer transport protein ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="23641" checksum="6D99F6C76022619F" modified="2020-04-22" version="1">MPRGKKRPLPEVSSGSMADIAFLLLIFFLVTTTIANDKGITLLLPPKPDPNEPPPEVTKNDKNIYKILANSSDQLLVEDEPYKGTMEDLKREVKEFVLNFGDPTEEGIIVYNSLPSPMKAEVNRFGKRLDSSDDPTECVVSFKAARGTSYELYINVLDAINGAYNEIYAQRVGISVEEWLALDKDDDIQKDMYNRARSNIPRAISIAEPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E235</accession>
    <name>A0A654E235_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="64"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="270"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="39417" checksum="5119404834938CA3" modified="2020-04-22" version="1">MKKAAYFCTPKENLNIINMEQVDLELRKEHQEKIKQVISEVGKVVVGQEYMVNRLLIGLFTQGHILLEGVPGLAKTLTVNTLSDVLKLDFKRIQFTPDLLPADLIGTMIYNQQKADFEVKKGPIFSNLILADEVNRAPAKVQSALLEAMQEKTVSIGETTFKLDRPFLVLATQNPVDQEGTYPLPEAQVDRFMLKVHVDYPTKEEELEVMRRMANMTFKSEVNTILSKEDIFSIREEINQVALSESLERYIIELVFATRNPKDYKLDQEAQYIQFGASPRASINLNLAAKAVAFFDERDYVLPEDIKAVADDVMNHRILLNYEAEADGVTTHEIIRQILNKVQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E244</accession>
    <name>A0A654E244_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="39307" checksum="37DD315EF872FDAD" modified="2020-04-22" version="1">MVDAIERELVLRKEELGGSPISSIYFGGGTPSMLSALELDRLLRSIHSTYEVIEDAEITLEANPDDLTGDKLQDMRTLGINRLSIGIQTFDDERLKFINRAHTSAEAEECLSAATSAGFDNISADLIYAIPPADTSYWQRDLEKILAYDLSHISLYGLTIEEKTVFGHRAKKGQLKEVKEEISAQQYQMAIDTLTQHGYEHYEVSNFAKAGKHSRHNSSYWDDQTYLGVGPGAHSYDGSSRSFNVSHNAKYLNQIQKGQLPITIEKLTPINQINEYLFTHLRTQKGINLPKFRRLFQRDFVSDNESQVQDYQKRELVKWDGETFALTSKGFMLADEISWRLFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E252</accession>
    <name>A0A654E252_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="8">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="7">
        <location>
            <begin position="232"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="8">
        <location>
            <begin position="366"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="446" mass="49408" checksum="D2B23615757CDC35" modified="2020-04-22" version="1">MRIIIAGAGDLGFHLARLLAYEEQDIILIDQDNAVLEHASNHLDVHTIRGSSTSISILEEANVSKADLLIAVTSIEETNLTTAIIGKALGAKRTVARISNIEFLHQREKLDLKTIGIDEIISPESLAAKEIKRLLKQSALTDTFEFEKGMLSLIGITVDEKSELLDKTLTETAYLNPDHNFTTVAILRENQTIIPHGENKFQINDHAYFITEPSGTDRVMALAGKEQIEIKNIMILGGSKVGINTAKQLSKKYNIKLIEQDKEKCFNLADELPDTMIINGDGRDIDLLKEEGIDRMDAVIAVTGNSETNIISCLVAKNNGVAKTIAAVENMDYIHLSQNIGVDTLINKKLIAANFIFRYIRKGQVINLTSIHGVDAEILEFEVQPNSKILEHELRNIDFPKTAIIGGVIRKGIGHTVRGSFHFQPKDRVVVLSRSECIHTVEGFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E277</accession>
    <name>A0A654E277_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="517"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="662" mass="74748" checksum="097E46720B5EC15E" modified="2020-04-22" version="1">MKQVFYALILLMMAQSCTQRVAQKSFEKGYYDRAIELYKKSLDPQDAHQNFMLGESYRKSNRLQEAAPYYSAARRAGSREPGLPYYLARSLKANKQYEEAEKILRDFLTKAGGDSNFKALAQVELDNLTKIDVLQAETNYFRIKNLDELNTKFAEYSPVYHNGFLYFTSNREGGKIYGATGTPFTDIYRVQSKGANINIRTLKALDPVINHSDTNEGSIAISSDGTSIIFAKGNTGKATGNTEVNLFFTRYRNSNWSEPRPISVNDPDAWDSTPALTPDGTTLYFSSTRPGGFGGADIYSAQLNRRGRWVDVQNLGPTINTPGDEMFPFVSEDGRLYFSSNGHPGFGNLDLFVATRVRGKITIENLGEPMNSAADDFGLHQFDLTRGFFSSNRPGGKGDDDIYTFINEDPDLKVVNYFLVGTTYTNDDGKHKIVLPNTKVALQAENGELLSEAFTGEDGKFKFRVYAEERYNLLGEKTDYFTTRKEFSTVGKSVEKASLTEFITNVTFQTEIMMDRIVLEKSIVLNNIYYDLDKANIRPDAALVLDSLVQIMNDNPDIFIELGSHTDARAEDDYNMDLSQRRAKSAVEYIIRQGISADRIVAKGYGESKLLIPNAVTEEQHQQNRRTEFKVLRYNPKKNEDNLPPVENQDEYDRFFDDSEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E295</accession>
    <name>A0A654E295_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ruvA</name>
        <name evidence="10" type="ORF">MARINOS108_20030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="21617" checksum="07AFDDBDA7FCE923" modified="2020-04-22" version="1">MINYLEGKLAVKDPTYVVVDINGIGYEAKISLITFAAIKNLTETKLYTHLHIKEDAHTLFGFSEESEKRRFLELISISGVGPSTGLMILSSLSPQELQQAILSDDVRTIQSVKGIGLKTAQRIILELKDKMKKEGLLEKGLDFVPSASNSLRSEALSALTTLGIGKPAAEKSIDLILKQNGQQIKLEELIKLALKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G9</accession>
    <name>A0A654E2G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division ATP-binding protein FtsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsE</name>
        <name evidence="5" type="ORF">MARINOS108_10240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="236" mass="26345" checksum="0CC3CBBF3758AF20" modified="2020-04-22" version="1">MSFSDEPIVSIRNANIFQDHATVLSEITFDIGKGEFLYLVGRTGSGKSSLLKTLYGDLPLRLGDIKVVGYDIRGIKSSDVPYLRRKIGIIFQDFELFYDRSVAENLYFVMKATGWKEKSKMKSRLAEVLMRVGLGSVSSKMPHQLSGGEQQRVVIARALINEPQILFADEPTGNLDPEVSDGIMKLFLEINKSGTSVVMATHNHHLLQKFPARVIKCEGGKIKDSTKENFELTGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I0</accession>
    <name>A0A654E2I0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <ecNumber evidence="4">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MARINOS108_20131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="13">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="12">
        <location>
            <begin position="170"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD18250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="406" mass="46160" checksum="8CE540D898788353" modified="2020-04-22" version="1">MGKIKIALIKEGKVPKDKRVALTPYQARQVMERFPEVDLVAQTSDIRCFTDQDYLNEGIQVVDSVDDCDILLGVKEVPIPNLIANKTYFFFSHTIKKQPYNQPLIREVISKKIRLIDYETLTDETGKRIIAFGRWAGIVGAYNGIWTFGKRYNLFDIRRASECFDLEDLKTEYEKVKLPAIKIALTGGGRVAKGAMEVLHGMNIRKVTPAAFIEEQFDYPVFTQLNTRDYHVRKDGGEFSRHEFYENPELYDADFLKYAKVTDLLIAAAFWDPNSPVLFKREDILKNDFKINIVADITCDIEGSIPSTKKPSTIEDPVYDYNPSDNEVESAFTDEGNITVMAVDNLPCELPRDASESFGNELLNNVLPELLSDDSREVIKRATITAGGDLTPVYEYLRDYVNGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J9</accession>
    <name>A0A654E2J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thymidylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016741">
        <property type="term" value="F:transferase activity, transferring one-carbon groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="2">
        <location>
            <begin position="65"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="37272" checksum="B8BED1D519ED2B4A" modified="2020-04-22" version="1">MVVEAQTIDEIITQVFHELLARDFDISTSRSKRHGPTSEVIGNLLVLANPRARISRSETRGKPFSALGEVLWYFSGTNKLDFIEYYISPYCEDAEPNESGEMIIHGGYGPRLMSFRETINQFQSTIDRLKQKPNTRKAVIQLFDAEDLLGNHKDIPCTCTLQFLVRRNRLHLFTNMRSNDAVKGLAHDIFCFTFLQELIACELNIELGTYYHSVTSLHMYEEQKDQAKVYLSEGLQGTKICMPKMPTTSPVLSMSKLLEVENEIRKGAAINYTKLELDDYWLDLIRLLEVFKHKGDKIKLIRIKNSMSSKIFDDYIQKRILTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P1</accession>
    <name>A0A654E2P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="16404" checksum="2F5939FAC63B52A8" modified="2020-04-22" version="1">MSLKTKIEAEIKQAMLNKDKARLTPLRAIKALILLAESEKGGGDEMSEEVELKLLTKAAKQRKDSLAIYREQNREDLAAKEESELAVIEEFLPKQMTEEELEQALKEIITQVGASGPQDMGKVMGVATKKFAGVADGKTVSMLTKKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U7</accession>
    <name>A0A654E2U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="414" mass="47061" checksum="DA3569E9B66EBC66" modified="2020-04-22" version="1">MKNTPIRFLVVLGTLSMVAILVVQVYWVSEAINKQEEQFNRSVQMALRNVVESLCELNGNDIPSSDPIDQLSNNYFIARTNYKIDLSSLDYLLKAELQKRGIAQDYEYGVYDCQTDRMVYGDFVSMQDQNGKTKPTGKLPKLINDEYYFGIYFPGKTAGIVSSLGIWQLTSLLTLLILIFFTYALFVILKQKRLSEIQRDFINNMTHEFKTPLATLQVSAEVLENEASGERQKKYARIMRSELGRLDKHVHQLLETSVLDYGKSKAVVPIRVKAVLDRVVEPFRALPGIQWNEKINLTDECTISGDPAIFETIVFNLLDNAAKYGESLIRLTASKEAGLLEVKVSNDGREIPRKERTRIFRKFYRIHQGDLHDVKGFGLGLYFVRQGARSMHGKVTVVSSPDLTTFTLTFPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E5</accession>
    <name>A0A654E3E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13984" checksum="8AEED47ACDD6C11B" modified="2020-04-22" version="1">MEKKFEIKLLDEAFEFIKSQNDKVQDKIFYNIRKSQILNDPKLFKKLNQNIWEFRTKYAGLQYRILAFWDKENNEMTLVCGTHGFVKKTDKVSPQEIEKAEQIRIEYFERKKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I7</accession>
    <name>A0A654E3I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="14118" checksum="0DF45BD1EF94A488" modified="2020-04-22" version="1">MDFKDNQAIYLQIADLFCENILLGKWNAGDRIPSVREMAVNTEVNPNTVMRTFNYLQEKGIIFNKRGIGYFVCEDGFEKTKALRKSDFVSQELPGLFKTMELLNLNMEDIHEYYQQFKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J5</accession>
    <name>A0A654E3J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="275" mass="31024" checksum="B791E50A5C6A2D07" modified="2020-04-22" version="1">MIENKSTEELKHILKELICSLEEGKLRSTSAIDWAPPIVSFGDPGTSTLATVGLNPSNLEFLDQNNIELDGYSRRFHTKKSLQIQNWGEINSQELSAIISKCISYFKNNPYDAWFKKLDYLISGSKYSYYFPTSNSCHLDLVPYATSTKWGLLTNSQRSKLLQISINSLGKILNTSSIETLVLNGRGVVDAFNSRSQGILYETLMPGWHLPRKNGNDVLGIAYQGFTDKVGDIKLDKSIRILGFNHNIQSSFGVTSKVQQEIRNWITKSIQYEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X9</accession>
    <name>A0A654E3X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="15158" checksum="D25EE904F4279328" modified="2020-04-22" version="1">MPTIFLGLLLLMALFGFISGTPTGGIAGLFGTGILGFVFYLLFMRLNSVKMDERNFYISNFRRTEELSISDLIEVSTGHFINAQRIWLTFRTDEPLNKSFLFMPYFSLEAIFSTHPTVKELSSIVEKNSDMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E416</accession>
    <name>A0A654E416_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="5692" checksum="899DB656F73809A6" modified="2020-04-22" version="1">MSLSKTIGTLIATVLVGSLTLLVATPKKVMKNKAKTTKTSTQNGIEEKENLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B3</accession>
    <name>A0A654E4B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="6" type="ORF">MARINOS108_60018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050049">
        <property type="term" value="F:leucine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="5">
        <location>
            <begin position="154"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="40379" checksum="D6A73493BED2B292" modified="2020-04-22" version="1">MIDTQPQVKNSEIFSTMARMEHEQLVFCHDEVLGLKAIIAVHNTVLGPAMGGTRMWNYQSEEEAVKDALRLSRGMTFKNAIAGLNIGGGKAVIIGDAKKIKTEALMRRFGKFVHSLNGKYWTAEDVNMSARDMEYIRMETPYVTGIPESMGGSGDPSPVTAYGVYIGMKASAKKAYGSDNLKGKKIVVQGAGNVGTYLIEHLLKEEATVFVSDIFEDKLAAVTKKFNVSVVDPKDLYTMDMDIYAPCALGATLNDITIPQLKCAIVAGAANNQLDEEDQHAEMLKSRGIIYAPDFLINSGGITNVYYEQQGNYNRQRVYEQTERIYEVCQEVLEYAENNETTTHQAALQLALNRIKDVGKVKLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J3</accession>
    <name>A0A654E4J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5452" checksum="89A156D3EDDC5101" modified="2020-04-22" version="1">MLIIGGINAQANPKKDCLYIALMFLLNNRQARNLPSENPIRIDLNNLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N2</accession>
    <name>A0A654E4N2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">kynU</name>
        <name evidence="8" type="ORF">MARINOS108_60138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061981">
        <property type="term" value="F:3-hydroxykynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="75"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="425" mass="47975" checksum="DDA33EB5D9335D68" modified="2020-04-22" version="1">MTYQNTPDFAKTQDQKDPLSRFRKEYHIPKKNNKEVIYFCGNSLGLQPKRTESFIQNELQSWKEHGVEGHFDGDRPWAEYHHFSKKSLARLVGGLEEEVVCMNNLTTNLHLLLASFYQPDGKRVKVMIEGGAFPSDHYAVESHMEHLGVSPKEHLIVLQPADGKTFRTEEITEAILKRGDELALILFPGVQYYSGQYFDMKAISETAHQVGAFAGFDLAHAMGNLPMNLHDENIDFAAWCSYKYLNSGPGGVSGIFIHQRHCSDPNFPKLKGWWGHDHNTRFNMDNQFVPNPGVDAWMLSNSNVISTAAHHASLELFDEAGMEALRKKSLSLTGYLEYLLSSGDLISRNIDILTPTDPEARGCQLSVFIAKNGKQIYDGLIAQGVILDWREPNVIRVAPTPMYNTFSEVYEFCQILKALIIIYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N4</accession>
    <name>A0A654E4N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="62" mass="7416" checksum="D0EE43C22022E6A4" modified="2020-04-22" version="1">MTSKRSLLTDFLTFIGFIQLDRSDIDQTRKRMGYPKSYLNTHTTYEKDKIRKQAKKMIELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U0</accession>
    <name>A0A654E4U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13424" checksum="9143A8467001818D" modified="2020-04-22" version="1">MQNRLKGVFQEKCPICGKGEVFETKGNVLLMKMPQMHETCAHCHHRYEIEPGYFMGAMYVSYGLNIAEMVAVLLVCLVIGVSLDYILYLAIFTVLLLWGFNFRMSRVIWMYLFNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W9</accession>
    <name>A0A654E4W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4841" checksum="FACCDB806CAD95D3" modified="2020-04-22" version="1">MLLLFKDCEFKLKFNLTNPSFIFFSRHQPFHAIPCPDRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z2</accession>
    <name>A0A654E4Z2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MARINOS108_140019</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010957">
        <property type="entry name" value="G/b/e-P-prot_chorismate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01807">
        <property type="entry name" value="CM_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="21">
        <location>
            <begin position="86"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="275"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="VXD17417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="353" mass="39920" checksum="9E028E1A02FE1ADF" modified="2020-04-22" version="1">MLEEFRKEIDQLDDELIKLLNKRMDIVQEVGKLKRSDKSAIYRPEREKAIIDRLTANSQGILNRAAIEAIFFEIFAVSRNYELPERIAYLGPEGSFTHQAAESRYGAMSDYIPLDSITSVFESVKTSRARFGVVPIENNQEGTVQETIDLLAQHKLSIAAEIVLPIHFAFASKEENLENIKTVYSRDIAFRQCKNFLNDYFKHPVKLVPVSSTSRACQIAGEEDGAAAICAPIAARQYTLPILYSNIQDSADNQTRFLIISQNFVNQVSGQDKTSVIANLPDEPGSLVRFLQNFQNAGINLCKVESRPAKEGTTFKYVFFVEFEGHFNEPKVQNTIQPYKNNITWLGSYVQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A9</accession>
    <name>A0A654E5A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdsC</name>
        <name evidence="5" type="ORF">MARINOS108_50088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="17579" checksum="A998FADCCB88E773" modified="2020-04-22" version="1">MSKLSHIKLLVLDVDGTMTDGGIYIMEDGRQFKKFHARDGLGIKEAIKAGVEVGIISHSLATEMVNSRANMLGMKHFYVGQRPKLEVLNEWMKALDISYSEVCFIGDDLNDLEVMQKVGFSACPADAASGIKKIAKVVLDRKGGDAAVREFIDRFILSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Q5</accession>
    <name>A0A654E5Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11577" checksum="A57EC9559F1D632E" modified="2020-04-22" version="1">MDEITLVNLLNKICEKNHELTWKLNCKYHDELHTSVMQIHFLQSNNLAETTKITFKMETGQVIEGKHRGFLGFKQPTMLIDALLDILIYEDSRIGSLTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5R8</accession>
    <name>A0A654E5R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligo-1,6-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">malL</name>
        <name evidence="4" type="ORF">MARINOS108_60156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="15"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="557" mass="64866" checksum="4BCC22D70DA5FF9B" modified="2020-04-22" version="1">MSVNKTWWKEAVVYQVYPRSFNDSNGDGIGDLQGIIQKLDHIKSLGVDVIWLCPVYKSPNDDNGYDISDYYDIMDEFGSMEDFDELLSGIHARGMKLLMDLVVNHSSDEHAWFKESRSSRNNPKRDYYIWKPGKNGGPPNNWPSFFSGSAWQYAEETNEYYLHLFTKKQPDLNWENPKLREEVYQLMRYWLDKGVNGFRMDVISVISKRNYDDTPHANFNDTIAQVYANGPRIHEFLKEMNRRVMSHYDVMTVGEGPGIDLDTGLQYVAEDEKELNMLFHFGHMFMDHGPGGRFDPKPIDFVEFKKIFRLWDEKFKNDGWGSIFLGNHDFQRIVSRFGNDADFWEESAKLLCLMLMTMRGTPYVYQGDEIGMTNVAFDRIEDYDDVEIMNAYAEWKAQGKDLDLFLKHVHVNGRDNARTPIQWDATENAGFTSATPWLKLNPNYTKINVADQQNAGNSILNFYRQMISIRKANPSLVYANYAVINEAHKQVYAYWRWDDAVRYLILLNFSADQQTFEVDDRFDIESLSLIIGNMGAVQMEGDKIFKLLPWQAALYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6E5</accession>
    <name>A0A654E6E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4860" checksum="C4906BC7D0AAF905" modified="2020-04-22" version="1">MPADGYGSIRSIYQLRFFSARNYFYKLFGHIEESNLACKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6H3</accession>
    <name>A0A654E6H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="193"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="339" mass="37511" checksum="DB023DE289464DDC" modified="2020-04-22" version="1">MKELSALKALLSTPKKIIITTHANPDADALGSSLGLYHFLKNRGHEALVVTPTDYPDFLHWMEGNDEVVVYGEKNHQQVAELFEQADLICCLDFSGLNRIKKLGEMVGSSKAKKLLVDHHLNPEQFADYELWDNKAAATAELIYDLILLLDGKEEINLAIAEALYAGIMTDTGSFKHGSTSAKIHRTVAELMEIGADVNKISRLIYDTNSLNRLRFIGYALMEKLVVNVEYQVAYFVISAEEHERFHLKSGDTEGLVNYALSINGIVVAAIIMEKGGEVKMSFRSVGDYAVNDIASEYFSGGGHKNAAGGISDLGLEETVEKFKSLIPKFQQTHNQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8L7</accession>
    <name>A0A654E8L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RDD family membrane protein YckC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_110027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="74"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD15851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27489" checksum="A9F26188D2597F57" modified="2020-04-22" version="1">MDKRNIFSDKFEKKSTDELLKVINEGGYEKEAKLAAIWELERRNEATDEQRNHANQLAEEQERKKASKLSGQRYQTFWLRFFAAIIDGFVMWPIGFLLSYITGSNIGVIVIIGNLLNSFAPYIYSIFLHGHYGHTLGKMAMGVKVVDFDNEDEIDLNQAFIRDSVPVALMILLYAYSFIIFYGNEGYELQADFVTLAPMFFIGLLNLLWTILEIFSMLFNDKSRAVHDLIARTVVVRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8S0</accession>
    <name>A0A654E8S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trigger factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trigger_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="439" mass="50640" checksum="1947FA529C6F6E5B" modified="2020-04-22" version="1">MDISLDKINKTEAVIKVNLKADDYQPGVAQKIKEYSKKANIKGFRPGKVPLGMIQKMYGKSILLEELNQLLSEKLNAYLRESDLQFLGEPMPKDDFESIDLDSQEDFEFAYHVGFAEEFELAINDKLKVDKHSIKIDDKVIGETIENLQKQFGELITAEVSEANDTLYGPIKSADGSIHKEISIDLNDVEKASVKKLTGLKAEDSVELDPKKLYTDSHKLHHQLDISHDAFDLLKGKMTFTVKGINRQVPAEVNQELFDKTFGEGTVKDEKEFKEKVKESVGKSFENEEEQYFDYQLKETLIEKAKINLPDEFLKNWLLKTNDQITPEILQDEYATYAKELKWSLIRNKIVKDQDFKVENDEVVEEAKNLIRKQFGQAGLIGQMEDKLEMFAQNYLQAENGDNYMKIYNQVQNNKVFGYLKENITIKDKKVTMDEFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8Z7</accession>
    <name>A0A654E8Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024969714" evidence="1">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21769" checksum="D91D7B9B4CDCD9C6" modified="2020-04-22" version="1">MKLPKQLWIMILLLLTFSHFATAQISVTRQKVTKDISMEVPESFIPMSQSELIGKYVSSRTPIAMYTSEDRNIDLGINETSSAWAGDDLPILQAFYKANIANLFTEVEFLQEEIREIGGRPFIVFEFISKITDEESTFGGNSSISKYTYIQYTLRNNKVLLFNFTCPLRARPQWQETAQRMMESVRIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9M9</accession>
    <name>A0A654E9M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="244"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="431" mass="47929" checksum="F1D8A09C9845B1C4" modified="2020-04-22" version="1">MESSKKVVNSWCMYDWANSVYNLVINTSIFPIYYTAVTANEANSDKVSFFGFEMINSVLYSYALSLSYLLSALILPLLSGIADYTGEKKKYLRIFTTLGAIACMGMFFFTSDTLEWGIICVLLASLGYSSGLVFYDAYLPEIAPASMTDRISARGYSFGYAGSALMLILSLILITFYESFGFANKGDATRTVFLLVGLWWIGFAQIPLKHLPANVFNRKPTGRILLNGYLELKKVLLALKHQPNIKKYLLSFFFFNMGVQTIMLLATLFGTKELKLGSGELIPVILIIQFVAIGGATLFARISDRKGNIFSLSLMIFIWVGICVFAYTITSVNEFYIVAVLVGLVMGGIQALSRATFSKLIPTDTMDHASYFSFFDVTFHISVVLGTFSYGFIEQITGSMRNSTLALASYFVIGFLLLIFVKMPKNQHAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9P1</accession>
    <name>A0A654E9P1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">MARINOS108_60154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="256"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="405"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="493" mass="55051" checksum="1DFEAF25D1867D3D" modified="2020-04-22" version="1">MAYIVALDQGTTSSRAILFNEKGEIVGIKQKEFTQFFPKSGWVEHDPEEIWTTQSEVFRSLLNELSISPKEITAIGITNQRETTVVWDRDTGEPVYNAIVWQDKRTSEFCEDLKSRGLEEKVRSKTGLVIDSYFSGTKINWILDNVENARAEADKGNLCFGTIDTWLVWKLTNGKAHVTDYTNASRTMLYNIVENKWDDDLLEILKVPMSMLPEAHPSAYHFGDFEFKGTTIPIMGIAGDQQAALFGQACFDPGEAKNTYGTGCFMLMNTGNKCEVSKNGLLTTMACSTTGELTYALEGSIFIAGAAIQWLRDGLRVLDHAEDSEYFARKVETNEVYLVPAFAGLGAPYWDQYSRGAIFGLTRDTGKNHIIKAALESIAFQTRDVKTAMEQDSGIEITSLMVDGGATNNNYLMQFQSDILGVEVDRPAITESTALGAAYLAGLHAGVWTLDEIKKVRKTDRKFAPGITKTERDHLYKGWQKAVQRTFDWAKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9Q5</accession>
    <name>A0A654E9Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="594"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="711" mass="80011" checksum="9C6D883A8EEF82CF" modified="2020-04-22" version="1">MSSISNQGTRRLLFILVLFILNDFAQAQNLPILNVNRRAGLEFDKFSYVNAKNLYMESFLQDSTQIEIISQIARCYLKLNNSVEAERWLKKLVETDSAQSDDIYYALAQQLSKNAKYEETAEVLRKLNEGKARDFRAESLARLDEFFASSMLYKVTSLDINSKRSDFGPMYYGDRIAYLSARQKNRWIDFNFSWDATEFLNFYSFSPGDSLDDVKPIADLNGAYHEGPGQLYDNDQKIVFTRNHVIKNKLGRQEDGISKLQLYFATRSEDESWLDIQPFEHNITSYSFGHPTINPSGNTLIFASDIPGGYGGTDLYFSVAQDSGWSVPANLGERINTQGNEMFPFLEGERLYFASDFWPGLGGLDVFVINPWGDSGKPVNLGAPINSSQDDFGLITDETLSSGYFSSDRMGNDDIYSFQSQFYTLSGVVKDLISGAPVDGSNVIFLDSLGRVFESVNTGMSNTFSINSTYTGTLIAFPVKSGLLVQDSLRIHIDPDFKGTKKIELFLFVPDLEIKILDESGQEIAQAVYYLKSIDAHKTLQPSKSEHVYEVTPGETYELFAAADGFYSKRDTFQVSGDYKGQGEHVVRLKKVVVGESIRLDHIYYDVNSADLRAESEVELDKVVGFMTDNPHLKIELGSHTDSRGSDAYNLRLSQKRAESATQYLINQGIDKTRITPKGYGESKPVNRCVNGVNCSAEEHQENRRTEIKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAN2</accession>
    <name>A0A654EAN2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ORF">MARINOS108_120511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="21130" checksum="7190C3FE7614A3E7" modified="2020-04-22" version="1">MSEFKWYVVRAISGREKKVKGYLEQEIARNGIEQLVTQVLIPSEKVYEMRNGKKRVRERNFFPGYILIQADLSNGETQHIITNTPDVIGFLGEGSTSASKDPVPLRQNEVNRILGRVDEAEEYEEKLDTPFIVGESVKVMDGPFSGFTGTVEEVFEDRKKLNVTVKIFGRNTPVELNYIQVEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBH2</accession>
    <name>A0A654EBH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="27187" checksum="3A88EF12D901DCAD" modified="2020-04-22" version="1">MQVKCLIIDDEPLAVKVVEKYIEEVDDFECVGSCSNGLEAIRFLNEQAVDLIFLDINMPKLSGMEFLETLKNPPQVVITTAYRDYAVESYNYDVVDYLVKPIEFPRFFRMVQKVMNRLSIKPAGPGSAAGEAEKIDHLFLKVDKKMVKVFLKDLLYVESLKDYVMVRTTAEDLIVHHNLHSFTDLLPQEDFMRIHRSYTVSLEKIKAINGNQVEIGGKHLPIGRNYQSEVKNRILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECA8</accession>
    <name>A0A654ECA8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">MARINOS108_20327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="59"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="33303" checksum="730B41EFB8165FB6" modified="2020-04-22" version="1">MIELPTVSQDKAQKIKKPNWLRVKLPVGREYANVRKIVDEHKLHTICESGNCPNMGECWGAGTATFMILGNVCTRSCTFCAVATGRPPEYDEAEPQRVAEAIKTMGVKHAVITSVNRDELKDKGAEIWYQTVKQVKELSPSTTIETLIPDVKSNWDALYRMIEPGQEVVSHNMETVERLYRRVRPQAKYARSLEQTRLTKEAGKRTKSGIMLGLGETIDEVHKAMDDLAANGLDILTLGQYLQPTKMHIEVAEFIHPDQFEAYKEEGLKRGLKYVESGPLVRSSYHAERHVNVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDF8</accession>
    <name>A0A654EDF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat-shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="143" mass="16360" checksum="28080A6EFF817F97" modified="2020-04-22" version="1">MTLIKYNPNGFKPATFGNFIDRFFNDDFYGGKGITSFSPQVDIAESDKEFEIQFHIPGIQKENINIDVKDDRLTVSGERKMSQEKTEKNYHTVESSYGTFSRSFYLPDNVNVDKIDASYKDGVLNIVLPKDAKKEMKKTIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDX9</accession>
    <name>A0A654EDX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="196"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="397" mass="43923" checksum="20438D00E86D93EE" modified="2020-04-22" version="1">MTETIAKIKSLSEAYFSDIQAIRHHLHSHPELSFQEFETADFIEAELRKMGITDFERKAETGITFMLKGREDNGKVVAMRADIDALPIIEANEVSYKSQNEGVMHACGHDVHTSSLLGAVRILKELKDHYSGTVKVIFQPGEEKLPGGASVLIKEGILENPKPDRILGQHVMPLIPAGKVGFRKGMYMASADEIYFTVTGKGGHAAMPENTVDPVLITSHIIVALQQIISRNCSPKIPSVLSFGRVEALGATNVIPNEVKVEGTFRTYDEEWRAEAHVRMKKMAEGIAESMGAQCDFQVMKGYPHLKNHPEYTQANIEAAKAYMGDENVEEIDLWLAGEDFAFYSHHVDACFYRLGTRNEAKGITSGVHTPTFDIDESALKTGMGLFAWLTIAELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEK0</accession>
    <name>A0A654EEK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">MARINOS108_50055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="141"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="531"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="587" mass="66390" checksum="28B5AAD979757F83" modified="2020-04-22" version="1">MLRTHTCGELRSSHIGQQVTMAGWVQKIRDKGGMIWVDVRDKYGITQLIFEEGKTDEKTLELARSVGREFVISATGEVVERVAKNDKIPTGDVEIRVKELTVLNESKTPPFIIDDETDGGEDLRAKYRYLDLRRGIVRKNLEMRHQLLQKTRAYLSDHLFTEVETPYLIKSTPEGARDFVVPSRMNPNQFYALPQSPQTFKQLLMVSGFDRYFQIVKCFRDEDLRADRQPEFTQIDCEMSFVTRKDILDTFEGLIKYLFKEVKGVDLGELPHISYADAMTKYGSDKPDLRFGMEFRELNDLTQGKGFVVFDSAELVVGINATGCGEYTRKELDGLTDFVKKPQIGAKGLVYVKCNEDGSFKSSVDKFYDQEALKSWAERLEASPGDLLLILAGESNKTRKALCELRLEMGSRLGLRDRSKFTAAWVVDFPLLEWDEDSQRYHAMHHPFTSPNPEDLDKLSTDPGSVRANAYDMVVNGVELGGGSIRIHDRTLQSQMFDALGFTREEAQDQFGFLMSAFEYGAPPHGGIAFGFDRLCALFGGQDSIRDFIAFPKNTSGRDVMIDSPSLIDSAQLQELHLSLTKPAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFE8</accession>
    <name>A0A654EFE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032530">
        <property type="entry name" value="DUF4957"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033427">
        <property type="entry name" value="DUF5123"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16318">
        <property type="entry name" value="DUF4957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17161">
        <property type="entry name" value="DUF5123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025046855" description="Fibronectin type-III domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="516" mass="55640" checksum="323477087102394E" modified="2020-04-22" version="1">MYTRIKKFTGILLCALSLVPMACKDDIDPVITELTKSRAFAPVGLEARVRNQVDIELSWTANPDVDQYVIEFFQDSLRFSGDPISTAIVDDIPTAGTITYTESLSGETRYSARVRAVTEGLEESNWAIVTARTDAEQIFLPLPGENVQDTYATVVWQPGSEVTHLLIVPGNTLVQISAAQVAAGEARIDGLSGATDYTVTLYNGTKRRGTVTFSTLKEANVTANDDLSSVINASEEGAVLILAAGTYNLGGKEITKSIVIEGQKWYDMPVIIGQFSCGTPVSSITLRYLNIQGQDDYGQMFNASASECNLGTLTVQGCEISGYSNNILYSNSGGTYGDIIISDTYIHDIPGGGGDGFDFRGGAVGSLTLENSTVANGIRTLLRMQVAADVAFRNCTFYRACIADNSNNRGFFRMSGGGTSLEVSKCLFVETGIEGSGGAIYGNWSQAGDISEEVSLNYRDNYYFNTIGLWEGEYTDPGEVDATEANPGFVDPANGDFTITNQNLIDEEVGPSRWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSX9</accession>
    <name>A0A654DSX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Four helix bundle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="13292" checksum="1AF12006C9C191D4" modified="2020-04-22" version="1">MRDFRKYKVWELGHEVTLVIYELTASFPDSERFGLTNQLRRASSSIPANIAEGCGRESDKDFKRFLYIANGSASEVEYFLILSTGLGYINKNDSEMITEKVSVLRRSLNKLISSIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT28</accession>
    <name>A0A654DT28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin-like protein CC_3178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="195"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="32554" checksum="AAAF104DA6509265" modified="2020-04-22" version="1">MSNADLIIEERSRDIGDFLVGRLLPFRKKRMVGPFIFIDHMGPSQIGPGHYMDIDQHPHAGLSTLTFLLEGEIMHADSIGSQQRIVPGSVNWMVGGKGVTHTERTPKDLRDGKSHTLHGYQIWVALPKELEEMAPEFHHLDKADLPKWEDGGTRFTLVAGEGYGRKSPLPVHSELFMVEVVATERYQLEIGNQLQGEIGICVVEGTVQACEHKVDRGHMLVSKTDGACSLSMEAGTHIFLFGGAPFPEERYIYWNWVSSSKERLEQFKTDWKNKKYPKVPGDDTYIPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTK9</accession>
    <name>A0A654DTK9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024889243" description="PKD domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="927"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1382" mass="151835" checksum="DA1CFA6C8079D592" modified="2020-04-22" version="1">MIKRPTYWLTLLLILISTYGQAQDSHVLPGVLYVKIKSSPSTADASTELFQFSEMENLKSYTPLRKNANGNRQKASVLDGLFKVVVDPSTDIAALCASLHKYANVSYAEPIYAAQLLYVPDDPESTTPNQEYLSVIRAFEAWDVTKGSSDIVIGISDTGLNLTHDDIKSKLYTNTNDPMNGLDDDENGYVDDFQGYDFADNDSLPKCDDSFHGNRVGGLAGAATDNGFGMAGVGFNTMISPLKVYSTALKFINSGYESILYAADNGYDVINLSWGGPNSYSQANQDIITYAAVEKNVVIVAAAGNTPEDIRFYPASYDHVLSVAASNLNDTKASFSTYNYDVDLMAPGNTIYSTDSGNGFAKDNGTSYSAPMVAGAAALVKSVFPDLNSLQIMQQLRVTSDPVYTTGTNQTYEGKLGYGRLNVSNAVREDSAKSIRLENLVYDNGNGNYAFYGDTIVLSFEAKNYLFPTDSATLSFTSASSHVEIIRETIYLGAMNTLESDSIQEKIFVIAKDTPPGTDLEIKVSITDGSYIDFQYIELTTDPDRLDLNNDQFSITLSGNGDLGFISDGYYNGVGFQWDDQLIAAKMGVAVSLDRSHVSDNFPDSIYTNTKASDFVAISPIRFAHHTTPDLHATSVFRDDSAATPLEIVMEQNTLTNRGANFLIQEYRLMNNATESREGLACSFYLDWEIFNTMQNRSFYDTESKTLITYNLDSSVVVGLLTYYDSLPRAQSLDLDVYNGNEQDVQMHYTDSVKYALAREVRFDSAGWQGNGNNVSVMLTHDSIALAPSKSRRVAYFMGLSHSFEGLAAVMDSARQVYEEYLNLPVLLERYVSCQGASVSIAPASGEVFRFFSDPLGENIIGEGDTLKTGAIVSDTTFYVANLDSGYEGSIQRIEIALLAQIADFQMSTDTLFLDNSVNSVTFTDLSFDPASWYWDFDNGSQITTQNATVYFRDPGVYTISLTIETNSGCTQTITKELLVANRPPLPDIEDQQVCADQDFTVSAPNADSIAVYLDGSSPTPLQEGPSITLEGISSDTAYYFTNTSGPFESLRKRVYFSINHANATFEYLPDTLNEATGVLFINTSPESASAQWYVDGLLKSELDTFYMEVRKASYEITLSITNTTGCANATTQSVTFATSPLPMAENQLICTGSNLLLEPNNGEWFAFYANEALSHLIKKGRNLTIAELKKDTTIYVTGLDSILPSAAIPVEITVALPQFSIVATPDTLYLSEQSTTSFSTNNDELIGWDWYIDNTPTETTSHPILYFDTEGVYDIVLNATGPMGCTNSDTLKYPVYQSRPEVLLGVDDSQQVIYPNPTTGDLFIVVTAPTEVTISDVSGRIMQKIYLEESALIDLNHLPKDIYLLTLKSQKEISNHRVIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTM1</accession>
    <name>A0A654DTM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15608" checksum="F141ECC9131E58BC" modified="2020-04-22" version="1">MKNTRPISKSRRWTARTMSGIAILFMLMDSIMKFIQPPTVVETTVALGFSEDQIYVLGILGLLSTLLYALPRTSVLGAVLLTAYWGGAMATHLRLDNPLFTHLLFPVYLAILAWGGIWLINEPLRELFPFHFQKVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU15</accession>
    <name>A0A654DU15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CusA/CzcA family heavy metal efflux RND transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="926"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1352"/>
            <end position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1458" mass="161887" checksum="A89841D1340477AB" modified="2020-04-22" version="1">MLDKIIHFSVKNKLIIGLLTLSLVIWGGYSLMRLPIDAVPDITNNQVQIITSSPSLAAEEVERLITFPIEITMATIPEIDEIRSFSRFGLSVITIVFKEDVDVYWARQQVSERLTDVQAQIPPGVGQPGMAPITTGLGEIYQYVVGTKPGYEDKYDARELRTIQDWIVRRQLLGTPGVADVSSFGGYLKQYEIAIDPDRLKAMNISIADIFQALEENNENTGGAYIEKNLSAYFIRSEGLVSSLDDIRNMLIKNNENGIPVLINDVAKVQLGSAVRYGATTRNGEGEVVSAIVMMLKGENSAEVIENVKNRIAEIRKTLPEGVTIEPFLDRTKLVDTAIGTVSKNLAEGALIVIFVLLLLLGNLRAGLIVASVIPLALIFAFGMMNLFGVSGNLMSLGAIDFGLIVDGAVIIVEATLHHLGLLKLGRKLTQQEMDKEVYHSASKIRNSAAFGEIIILIVYLPILALVGIEGKMFGPMAQTVSFAILGAFILSLTYVPMMSALVLSKKTEYKPNISDKIMTFFHRLYDPTIRWAMHKRPLMIAFALGLFGISLWVFSNMGGEFVPTLEEGDFAVETRVITGSSLQNTIKATTQAEKILLEKFPEVTQVVSKIGAGEIPTDPMPVEAADLMIILKDKEEWVTASNREELANKMAEALEVIPGVTFGFQQPIQMRFNELMTGVRQDVAVKIYGENLDELSEYARQIGKLVSGVEGAVDLYIEEVTGVPQIVINYKRAQLAKFGLTIRDVNRSVQAAFAGASAGLVYENERRFDLVVRLDKTNREDVESVRNLYIARKDGHQIPLYQVADVEIKEGPYQIQRDDTRRRIIVAFNVRNRDVESIVTELQQKIDQSVVLAPGYTVSYGGQFENLVEARERLAIAVPLALLLIFVLLYFTFGSIKQGILIFTAIPLSAIGGIFALWLRDMPFSISAGVGFIALFGVAVLNGIVLISEFNHLKKEGITDIFERIYKGTSVRLRPVIMTAAVASLGFLPMALSQSGGAEVQRPLATVVIGGLITATFLTLVVLPILYYYFERGIKVKPGTVALLLFIGVLFFQFPEAKAQESQKIYQSLDEAINTAIQNNPGLKAADLQTQQERSLRGASWNLPKTNFSLTHGQYNSIYNNDNQFNISQSIAFPTVYANQSKLANAQVEASEWQKTATQNELVRQVKATWYFLWLEKNKRQLLIEQDSIYQRFVRAASLRYETGESNLLEKATAESQVAEIKAMLQQNLADIEIYQTQLQTLLNIEGSLDIMAGKLEVRQSTALLDSQGITNNPTLAWFRQQMKVAEREKSVEKSRLLPDLTVGYFNQSLNGPNQDIDGNPVTYTSSDRFTGFQVGVAIPLFGAKSQGSVIKATELKKQEAEAQLEAITNELQGRLKSLIQQYQKFQASLDYYEQNALPQAELILKQAQKGFESGEIGYVEYVQGLNRSLSVRFNYLDILNQYNQTNIEIEFISGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU28</accession>
    <name>A0A654DU28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">leuD</name>
        <name evidence="12" type="ORF">MARINOS108_10131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD10620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="22265" checksum="EB0AAC467C078C46" modified="2020-04-22" version="1">MAYDKFEILKTTAVPLPIENVDTDQIIPARFLKATTRDGFGDNLFRDWRYNSDNTPKQDFILNNPLYGGKILVGGKNFGSGSSREHAAWAVYDYGFRCVISSFFADIFKNNCLNIGVLPAQVSAEFLDKIFKAIEADPKAEFEVSLPEQTVTIVATGEQESFDINSYKKGNMLNGFDDIDYLQSMKDEIKSFAEKLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU37</accession>
    <name>A0A654DU37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.117</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dapD</name>
        <name evidence="6" type="ORF">MARINOS108_10526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.166.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023180">
        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037133">
        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14805">
        <property type="entry name" value="THDPS_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_N_2" evidence="5">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="29716" checksum="13C404693F7EFA42" modified="2020-04-22" version="1">MQELREIIESAWDDRSLITNKEVSVAIKTLIDDLDMGKRRIAEPLENGEWQVNEWMKKAVILYFPLMKMQLIEVGPFQFHDKIKLKSGYDQLGVRVVPHAIARYGSFINKNTVLMPSYVNIGAYVDEGSMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPVQAAPVIIEDNAFIGSRCIVVEGVRIGKEAVLGANVVLTSSSKIIDVTGPEPVEHRGYVPERSVVIPGTIPKTFAAGVYQVPCALIIGKRKESTDKKTSLNTALRENNVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU73</accession>
    <name>A0A654DU73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="6613" checksum="B5CD4336C535C1B5" modified="2020-04-22" version="1">MAKGTFRGKLILMFYINQLRHDVSSNPKGCFIALRVFATPCFTNTVCSGLSKKQGNYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUA0</accession>
    <name>A0A654DUA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="487" mass="56186" checksum="CDB90929CC9E905B" modified="2020-04-22" version="1">MCLLAARVLGNSISGQVLDAETLLPLPFASISVMDSQLGTISNSEGYFVLSSESILGTDTLLFSYMGYETFKRAIQDFEKSPLVYLRSVEINLDAVTVYSRQLTGREIIGQVRENYSKNHPERSEMRRMFYHKFERTPFPEDNQIHVKHSDFVGMDKATIEGLLKMLPDEFTEYQDAVLSFYNYEDKHKLVPVEAISLEEDAMQDLEAIFEKKLGAFFEDIEKSKGNQEIYYKFRTGIFAMKADTNPNEDTGALEPHADSLHYRVPTTQLDGEVSFLLKDYGSLRSDNWEFITKPNRYDYRMEEVTVFNGELVYQIAFTPRERGLFEGTLYVSTQSFAILQLDFAYAPGKTSENIHLLGFGHSMNSKQGRVIFEKGAEGYFVKYIQAKQHETASIARDFTIMKKQKRFLIDKELNEIKLEASLTFEIHSDWELLILDRKPLEANEFETVKQPALVRFRKEYSNAPDLWDNRTVIAPSAELMKYTRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUK8</accession>
    <name>A0A654DUK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor GreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Transcript cleavage factor GreB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">greB</name>
        <name evidence="7" type="ORF">MARINOS108_10696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GreA/GreB family. GreB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00930">
        <property type="entry name" value="GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006358">
        <property type="entry name" value="Tscrpt_elong_fac_GreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01461">
        <property type="entry name" value="greB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="6">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="5">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="20110" checksum="718193A04FA9F482" modified="2020-04-22" version="1">MRRKIPESTLPKIIRSQMITAEGLQKLRDEHDHLWRVERPETTAKVSWAASLGDRSENADYHYNKKRLREIDKRIRYLCNCIDNFKVIHYHPNQEGKVMFGAWVEVKNEAKGLQKRFRIVGYEELTDNKDYISMDSPMAKALLDKTVGDVAIVQTKLGDFVWEILKITYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN4</accession>
    <name>A0A654DUN4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="78"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="28756" checksum="68B8EA248EE798F4" modified="2020-04-22" version="1">MFFIASKALFFLISPLSWIVTLLLLAVFARKEGLKKYSLWGSLLLLLVFTNPMLSNYAMVEWEHAATPKDQLPYVETAVVLGGMLEPGKEPIDQYHFNGSADRINEALILFKEGIVQKLILSGGSGSLMDQTLREAHFLGAYSQTLIEAHDDQIFMEANSRNTYENAVETARILDSLGLKEQKVLLITSASHMARALRCFKKQGIIVIPFSVDFRGQQGNWSPFWILPSHTALEDWNILIKEWVGLLTYRLTGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP0</accession>
    <name>A0A654DUP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pantothenates transporter PanS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">panS</name>
        <name evidence="3" type="ORF">MARINOS108_10728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="371" mass="39442" checksum="80439E4F7265C5DA" modified="2020-04-22" version="1">MKNNSLNTLFLYLAVGFLIAAIIMFMAESLTAGALLLAGFWLSLAVGIRRFPSFGQLAFTLLIFAAVTLSMGFPSAFTQVGSLQLKSLIVPLLQVIMFGVGTAMSIGDFRGVLKMPKGVGVGLLCQFTIMPLVGFSIAYLFGFPNEIAAGIVLVGSSPSGLASNVMAHIAKANLALSITLTSVATVLAPLATPFLMSQLGGEFVPVDVSAMMMSVVKMVLLPVGLGLVFNHFFHGKFTWLDRLMPKVSMAGIVFIIVIITAAGHDSLLNVGFLLILAMFIHMTCGYFLGYWGARLFKMPENDCRTIAIEVGMQNGGLASGIAASMGKISTLGLAAAVNGPIMNITGSMLATWWSRKMPETQPETFTKMETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ1</accession>
    <name>A0A654DUQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027840">
        <property type="entry name" value="DUF4493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14900">
        <property type="entry name" value="DUF4493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="27273" checksum="CD623C3A3A78744D" modified="2020-04-22" version="1">MKKYTFFLVVCGLLWQSCAKSDRVEPVIQEANHGLLAITIGEPDIDVSHGRQTEDYTDAHVSIISLSGGENVEYASIGDVPDSVELEVGNYYVHAYTDSIPLPAFDAASYVGNSEWFPIGDDSLTHVEVDLGLNSVKVEVNYSENVQTLFYDYHVEVFDEHSGSLYFGKNETRKGYFIPCELTIHAVLHYVNSSSDSTSIEKMVSVDGVKNDFLIITVDGDLEFGEAIFDFNLDSLNVREIDIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR0</accession>
    <name>A0A654DUR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="473" mass="54449" checksum="B8E182E7723B24C4" modified="2020-04-22" version="1">MRWKWLFGFVLFAFLHSVKGQDTTDTLSLSFKDLPLEIVLDSITYKSGYYFSYNADAIPKGSLYTLTRKGIHIDNLLNILLVGTMLEHSRYEDQIIIRAKQGVSKEGVDGSRGKVQITGWVREYRSKNAIEGVNVFINGTTIGTVTDQYGNYRLTDVPHGSYILVFSHVAYELASYSFKAENNNSYAINGLLDFKVRTLDQIEIISDPIVSEDEWPRYYRMFKKEFLGSSANASRCEILNAESLDFSYNEDTRVFTGEAQEPLIILNEALGYQVSYELEHFERDDDRTSFYGKARFTPLDPESNRIRKKWRKNRMKSYYGSITHFFKSLIADELKEEGFRIYSVKDVSEIFNKKMVEIEPDDILARGTNRYEWKLDFDDYVMVSYDKEVESTQYLSSLNEDEISSNGLGPTSGINSHQPGAQKSMLELKRTYVTLDHNGQIKEPLGLTTIGYWSWERVADLMPADYDPKADNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW5</accession>
    <name>A0A654DUW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4266 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025362">
        <property type="entry name" value="DUF4266"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14086">
        <property type="entry name" value="DUF4266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024822477" description="DUF4266 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4266" evidence="2">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="69" mass="7481" checksum="8D99AE34BA39E83E" modified="2020-04-22" version="1">MKQLVRLLILAGVLSSCASLKPYERQYVDDPEMQMDFDNGVRFSNYVHSIREGATPAGAPKSSGGCGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ6</accession>
    <name>A0A654DUZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="50699" checksum="30D0B1F62426E7FB" modified="2020-04-22" version="1">MRNRRILIVTYYWPPSGGVGVQRWLHFARNLKEMGWEPIVYTPENAQFDIRDESLLEDCKNISVIRRKIWEPFTLLHQLTGNRNRNAIKQGSALEKSDKSWKEQLIIWIRGNLFIPDPRLFWVRPSVRFLKKVILEKEIETIITTGPPHSMHLIGLGIKTGLPQVQWLADFRDPWSDWDLLDKLKVGRLAKFFHRWLENKVLRRANKILVTSSGTANLMFKKHNITAEVITNGINETYDYLGKPTSLAGKFVIGYFGMLNEVRNPKVFWQALEELCEEDSTFLNSLEIRIGGIISESVSDELQGYKFAENIKFMGYLPHGSLFEEYTECDLLLLLQNKSENSKFLIPAKFFEYLVAGRPILGLGEVPSDLSELFSNRQIGVFLSHYSFNEIKEFLRTVRSGIESNKEDYIKLISLYSRTNQARKLIQLLETQMGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV83</accession>
    <name>A0A654DV83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024869996" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13399" checksum="C93A168D9F2EC8EA" modified="2020-04-22" version="1">MNLSVPIILLVILSSCGASNAFILNQNQNATQVHLASGNYRVVDKVRGSADVSYVLVFGGMKKKQLFANAYADLMNNADLTTGSRALVNMVSEEHIGGVPPFFYKRTVTVSANIIEFDKTSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD9</accession>
    <name>A0A654DVD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase B</fullName>
            <ecNumber evidence="6">1.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aldB</name>
        <name evidence="6" type="ORF">MARINOS108_10683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.22" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008911">
        <property type="term" value="F:lactaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="53"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="532" mass="58628" checksum="CAE3894BA62278BE" modified="2020-04-22" version="1">MDLDAHQKGISKMGALLGKTKRLQKMETLTKEHKAVERPPFKPAYDHFIDGKWVAPSSGEYFDNISPIDGKVFTRAARGNQEDINKALDAAHTAFSSWSTTSAAARANVLLKIADIIEENLEMLARVETIDNGKALRETRAADLPLCVDHFRYFAGVIRGDESTMSEHDEHTVSLNLQEPLGVVGQIIPWNFPLLMATWKIAPALAAGCCTVVKPAEQTPTSIMVLMELIAEVVPPGVLNVVTGFGTEAGKPLATSPRVAKVAFTGETTTGRLIMQYASENLIPVTMELGGKSPNIFMPSIADADDAFFDKCVEGAVMFALNQGEVCTCPSRILVHESIYDKFMERVIARTNAIKMGHPLDGEIMMGAQASNDQFEKILSYLDIGKQEGAEVLCGGEAAQLNSGLENGYYIKPTIFKGHNKMRVFQEEIFGPVTSVTTFKTMEEALEIANDTLYGLGAGLWTRDAHEIYQMPRAIKAGRVWVNCYHAYPAHAPFGGYKKSGFGRETHKMMLNHYRNTKNMLISYDKEKLGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF9</accession>
    <name>A0A654DVF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenical resistance protein ArsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="185" mass="20592" checksum="7B2D4EC3BBC23B93" modified="2020-04-22" version="1">MNILIFNGSLESQSNTTPTRIARAFTNHLEQRGATVTTFHLSEAGIPLFDFSFEETPSSVVDMVSTFRAADMHIWLTPLYHGSMTGAMKNCLDWLEISAREEVPYLTNKIIGLVCWADGAQAMQGINAMDAVAKALRAWVLPYSIPIVRGNLFVADNQEMSPDYLEKIELMSTLLSDRLPSNFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVM8</accession>
    <name>A0A654DVM8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sortilin-Vps10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sortilin-Vps10" evidence="3">
        <location>
            <begin position="119"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="901"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118465" checksum="21312F41A74F1578" modified="2020-04-22" version="1">MKRYFTYLLITLPLLIYSQKVDMELLKGIQPRSIGPAGMAGRVTAIDVVNSRPEVIYAGTASGGLWKSESGGTAWEPIFDKQTTASIGAVAIQQSNPSVIWVGTGEGNPRNSLNGGDGIYKSLDGGKNWIKSGLDKTRNIHRIIIDPQNPNTVYVGAIGSPWGIHPERGVFKTTDGGKTWKKILYVNDKTGAADLVMDPSNPNKLMVAMWEHYRQPWFFTSGGPGSGLYVTHDGGENWVKRTDEDGLPKGDLGRMGLAIAPSNPKIVYALVESKKNALYKSEDGGFKWTKVNDKSEIGNRPFYYADIFVDPVNENRLYTVYTYINVSTDGGRSFDQLMPAYNTTRGVHPDHHAWWIHPSDPNYIIEGNDGGLNISRDRGTTWRFVQNLPVAQFYHISVDNDFPYNVYGGMQDNGSWAGPAYVWKDQGIRNSYWQEVSFGDGFDVVPDPDDNRYGFSMAQEGWVGRYDLKTGHFEYVKPHAPELDVKLRFNWNAAIGQDPFDSKTLYFGSQFVHKSTDKGQTWDIISPDLTTNDKSKQKQDESGGLTMDATGAENYCTILAITPSVLEKDVLWVSTDDGNIQLTRDGGKTWTKVSQNIKNLPVNVWIPQIQVSNKNAGEAFVIANNYRNFDFKPYAYHTTNYGKTWERIVDENDVTGYALSIIQDPVEPKLMFLGTDDGLYISIDAANTWTKWTNDYPTVNTMDMVIHPREHDLVIGTFGRAAYVIDDIRPLRALASAGISILSKPIHLFEPPTAYNAIWQQPTGTRFGADAMFNGENRKSGAMLSYVINVPKKDDDEKEKSKEEDEKKGLDSLTLEVFTLDGNLIRTIKQKVPEKNGVNRMYWRLDEKGVNSLTRKELDNKREPGGVDVMPGTYKLRLSYAGESSETQVEVKFDPRMDVSMEALQARYEALKALESEKELALGRVEQIKEKLTIIDELTKRMKAKNEKAFEAELKRSKETKDTLNSLLDLYLGKEDDRQGITADQTDNVDSYYGTAYFYLSNGLHVPTRTEKAMVAKFKSVMEVANQKTDDYLAANWAQYKEQMEALDLSPFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVM9</accession>
    <name>A0A654DVM9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="97" mass="11025" checksum="B1E1B125D38C2411" modified="2020-04-22" version="1">MTDHLTSIGIQIIPKSKALHTYDLVDEAIAVIQASGLKHQITPFETVMEGKYEEIMKVCDQAQKAVLAAGAEECLVYFRIHYRKDADVTFEEKRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVN9</accession>
    <name>A0A654DVN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative outer membrane starch-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024973210" evidence="5">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="81"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="345"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="499" mass="55947" checksum="6AED91594C1B7C15" modified="2020-04-22" version="1">MKYLNKILLFALAFGTFNCADLEEDPIGNLAPDGFFRTPGDVEMGIFGAYGLMTQETFWGRKLSTTIQLLSDMADIGNTSTAARRIEINEFTMDATNGMITEFWPASYQIIASANNAVFGAQNVSADPEVKRALEGEARFVRALIYYHLVRLFGDIPYVTETTPANDLPTLSKTSEDEVYQFIIKDLEFAREHLPMQHPGNIRSRATSGSAYTLLASVHLTLGNWQDAYDNAKWVIDNRAALNYDLVPDFQDLFNSALQDDQVETIFSLDYLGLVTKNNLNDDFMGAMTGIRGADKNGWGVNVPTMAVFDSFSDSDYRKAVTFESATLIGDSLVSYPDYPFEKRPHCAKYFRFYGNAQNEGRKTDNNYAFFRYAEVLLIAAEALNEISGPSAEAQGYINQVRARARNGASTPADVSAIEAADAAAFRATVMEERRVELAFEFKRWYDIKRRKLGNEVFLGANSMEPQPNFDPSKHYYLPLPQDELDRNPNLLPQNAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX9</accession>
    <name>A0A654DVX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">era</name>
        <name evidence="12" type="ORF">MARINOS108_11145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="8"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="33854" checksum="700CF7506CAA4E81" modified="2020-04-22" version="1">MTEAKPFKSGFVTIMGKPNVGKSTLMNQLTGERISIVSNRAQTTRHRIFGIVTTPEYQIVYSDTPGTLDPSYKLQERMMGFVKKSLEDADVILFMVELGEKNDHQEWIDMARRTEIPMLFVINKTDLGKGSQVEDKVTYWKEQLDWAEPMTVSAVTGEGVDLLQQTIVSHLPEHPPYFPEDEMTDKSERFITAEIVREKIFLQYKQEIPYSSEVVVTSFKEEEKIIRIAAEIFVERDSQKGIIIGKKGESIKNLGIAARQELESFFGKQIHLETFVKVEKDWRKDDSKLKRFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW44</accession>
    <name>A0A654DW44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">yidC</name>
        <name evidence="16" type="ORF">MARINOS108_10940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="88"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="609" mass="69353" checksum="DFB989909A486234" modified="2020-04-22" version="1">MDRNQLTGLILMLVFITIYFQFFAPEPNPEQISQLNRSDSSQIIDDPQQSAIGQPGTTVLSDSARARLSEMKFGLFSSAADGEEKITTIENEKMIVSFSSKGGVVNKVILKDFKDFRGAPLVLVDDAHAAQHIYVDHLSRKVDLSELYFTGRGRSNVTKAGDTTVLEYRLTLPEGQSVTYKYTIPGDGYEIGMTVVQNGLEPIIGQQVTFAWNQRANRLEKDFKDARNRTTVKYRFTDGDVDELSATSTEKEEETLDLATSWVSFRQKFFTSAIISATPFTNGQVSSYTNFEDTTSVKNMAMSMTLPYADFIGNNSTFKFYYGPNNYAILKDVAPDFSENVELGWSVLSWINKFAIIPIFHFLEQYISNYGVIIIIMVIILRIVLAPLTYKSHMGMAKMRVMKPELDELKAKHGDDAQKAQQEQMALYQKVGINPLSGCIPMLLQMPILFAMFYFFPNSIELRQESFLWATDLSTYDSIWDLPFDIPFYGDHVSLFTLLMTASTILYTWSNSQMTTVQGPMKSLQYIMPIMFLFFLNSYSSGLTFYYFVSNIVSFGQIALFRKFIDEDKIKKVLDENRKKNVNKKKSSFQQKLEEAMRAKDQKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW45</accession>
    <name>A0A654DW45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="20107" checksum="09B9FD3DC619D2C5" modified="2020-04-22" version="1">MLKKAILNFKAKRILKKRSQELMTDFKSSQKIAIIYSDLFENEKQISEIVNELKKEGKEISMMVYCHSIKKKTTALPHFHSKEISLTGEIKSEDLNFFLRQSYDFALCFDQSRHFIIDYVFSQVKAKCRVGIRTPSRDHLFEMMIQADDQQTPLSSEVLRYLKMIQSYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB9</accession>
    <name>A0A654DWB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="DUF2183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2183" evidence="1">
        <location>
            <begin position="174"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="34373" checksum="0AFC104CFB25FD62" modified="2020-04-22" version="1">MRNSVPFLKVYQSFASDHLTIVMGHVLKSPSHQRDRPTRNPFKNALEMYRRYHVKPSAGEKVFLTLAGKVMEVTADRKGFFQFELSTPRDVDTLEVTVALADFPTEYEHLKLEVHRPAEVIVSDIDDTILVSHSTSLIRKLYLLLTKNHQSRQAFDGVKDFYDSLKEGRTEPLFFYVSSSEWNLYDFLESFVADKQLPAGVFLLQDIKSGILDLFRSGGGSHSHKKSKIETLIKVYPEAKFTLIGDSGQKDPDIYQAVALTYPEHIAKIYIRDVRKSRRSKVKQMASALKNSGVDMVFFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD2</accession>
    <name>A0A654DWD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="22960" checksum="C5879BEFED745F1E" modified="2020-04-22" version="1">MHQIEPYHNWQQYYDASEDPQSPFYGKEYNYDLYSENIYGYFIDPAWDFFGSETLYMKVLFANYEEGFIIIELIGEWNDAINNDIMHLKRNVVEHVMHTGINKFILIGENILNFHGSDDSYYEEWFEEVEDGWIVAINFRDFVEEEMARFEIDSYVNFGGHLKVVNWRTMTPTVFFAGVSQLMQRRLQMGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK6</accession>
    <name>A0A654DWK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="167" mass="18681" checksum="6EEC3A9F4CEE120C" modified="2020-04-22" version="1">MRIGIISDTHSYLDPSVFKYFSQCDEIWHAGDIGTLDVLQQLEAFKPTMAVFGNVDGHDVRAASPEDQVFVREGKKILMTHIAGSLPRYNPRVRDLIKTHQPDVLVCGHSHLLKVQPDKANNLLFINPGAAGRHGFHKIKTLLRLEIQEGKIQNLEVVELGPRGQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN3</accession>
    <name>A0A654DWN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIPSNAP family containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024793968" evidence="1">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="160"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="30376" checksum="B33514644CFF3A20" modified="2020-04-22" version="1">MKPTNSFFLLICLMALGCQSKKAANSEPAPERQYYELKTYTMATDQQVSMTDQYLRETYLPAMKRLGVANIGVFKPRPSEADSSQKIVVLLPLTSMDQLLTITDQLVEDSIYQAAGADYLNAPHDNPPYERIASVLLRAFTEMPMMQTPKLSGARADRVYELRSYESATEKYYWSKVDMFNAGGEVRLFNKLEFNAVFYGEVISGDKMPNLMYMTTFTDQQSRDAHWKAFGESPEWQALKVMPRYANTVSHSDIYFLYPTEYSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ9</accession>
    <name>A0A654DWQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="23343" checksum="23F3696BD22B3562" modified="2020-04-22" version="1">MARVIKFPVTPPEKLGPKKVKRKRRRPDPEDYGQMNLFDGPVKEGRLVSLPQSDSFFEEALMLDEQNDPEAEKYYLLAIQHDQSVVDAYCNLGILKSQQNELAKSIDYLTKCLELNPRHFEAHYNLANVYSDMGNFPLAKTHYEVSINIDPDFPNSYYNLGLVLISLKKYKEAIDAIDQYINRSPDNDHKIASELIKTLKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR9</accession>
    <name>A0A654DWR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5782" checksum="845856BECEDCBA27" modified="2020-04-22" version="1">MEGETGFYAMKIFLNKLNPIILYVTYVRQILQMESFKKLNQSTYFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN5</accession>
    <name>A0A654DXN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3D (Asp-Asp-Asp) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025011075" evidence="1">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15541" checksum="57DE36EF9B5DB4D9" modified="2020-04-22" version="1">MTLIAAFRRFHLWLFLSFGLLSSAHVMAQPPRWDTLEVRASAYNSVTAQTKPNDATTAAWGDQLVPGMKAIAVSRDLIALGLTHNTRVKIEGMEGVFLVKDKMHPRWTQKIDIYMGEDIQKALIWGVRPVKIFYEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX7</accession>
    <name>A0A654DXX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024821394" evidence="5">
        <location>
            <begin position="21"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="94"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="374"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="533" mass="60228" checksum="126FCAD9C2B1D99F" modified="2020-04-22" version="1">MKNYRIFQIMSLILMGSVLNACFGDLDTEPLDNESITSASIFDDEAAYKQFLAKLYGGLTLTGQRGEYGQPEISATDEGTTSFMRTYWSAQEVTTDEAINAWGDPGLVEFHSQTWSDNNLYIKLMYQRIFINIAYCNEYIREVGQRVDGLSNPLRAEVTTYLAEARYLRALYYYFAMDLWGNVPFVTENDDTGAYLPKQIARGDLFLYIESELEAILPALVDARQNEYARADKAAAWMLLAKMYLNAEVYLGEGNDRFSDCIVQCNNIISSGAYTLHSQYSHLFLADNDRLRNEIIFPIAEDGDNTRNYGGVTYIIHAAVGGTQDPDKDFGIGSGGWFGNRPTTTFVETFEDPTGDTDHRAMFYTDGQTLEIENPTVFTEGYLCEKFKNITSAGIKGKNDIFVDTDFPLFRLAEVYLMYAEAVKRGGAGGNEATALDYINALRTRAYGNTSGNISMADFTLDFILDERGRELYWEGHRRTDLIRFGRYSDGDYMWDWKGNVKDGKTMPSHLDIFPIPSADLGLNTNLKQNKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY50</accession>
    <name>A0A654DY50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="10978" checksum="EE36591C4DA80B07" modified="2020-04-22" version="1">MIAIKESFAKILEQPDRVAVRDLLKSNFGELNYIDFKADWIENDKLARHILAMVNSGGGIIFIGVSEQDGKIEPSGLSSIRDKADILFEQVTTEQLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY98</accession>
    <name>A0A654DY98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="516" mass="59697" checksum="4130C990E7AE62C8" modified="2020-04-22" version="1">MKKMHSILIVLLLNFSIGFAQENLRIIEGLSIESEILGQAVKYSIILPEEYHATKKSYPVVYLLHGLGDDESSWLEYGRVNQYTDGAVKQGDIQPMIYVMPQGFRNYYVNDYAGTFLYEDMFIDELIPFIDNTYRTIPDRDHRATMGYSMGGYGALILPLKHPEVFTISVPLSISVRTDQQYMTEDASGWDDQWGRLFGGVSETGENRITDYYKQHSPFHIFKAPNLTKFSDLKLYIDNGDDEYTLCRSNEELHILLRDRNFPHEFRVRDGGHEFSYWREALPNGLRFISDAFDGKKYRGDIRAVEDTIPTNADIRIIKETQYEIVLPDDYSISNRLYPVVFFIGDFQSQEKKDIIEKVQYDMETGHLAPMIVAFINEDETGLLETIIPDIERNYRARSGYRFRALIGYNKGGATALEYALNPEVFTSCVVFDAPLDCSSLEEAFSKNKKALHRTWYFINTTEDNPNYQANGCAHVFLREEDVYHEYRVRESTGRDANDLVGLSEALRFTQRKIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD4</accession>
    <name>A0A654DYD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025054170" evidence="2">
        <location>
            <begin position="29"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="4">
        <location>
            <begin position="42"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="3">
        <location>
            <begin position="262"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="777" mass="87629" checksum="5186ADACEF611964" modified="2020-04-22" version="1">MVKNKLYIHFLLCLMLGVAGSCKLNVNAPDKFEDTKSLTELVYPALDTENSRWFFFSSASRPFGMVNLSPDTEIDGAWGSGYRYKTDTIKGFSHIHAWQMSGVSVMPVTLSDANENTIYKDFYSGFSHETEKISPGYHYVELDRYGIKSALTSTTRVGLHQYTFPKNARPAMLFNLHTMLGPCANIDGELTLSGDNELSGKVVMEATGRRPKPFTVYFKVMFSTDVAAIEQDSETKNYLVRLTNPEEEVLMKVGISYTSVDNAGLNIKEELPHWDFDRVVSQSKNEWNGLLGRIKVEGGTETDQRRFYTDLWHALQGRRIINDANGAYPDNTGATFRVGQLPLDNSGKPQFNHFNSDSFWGAQWTINTLWGLVYPEIKQQFVLSLLQYQKDGGLVPRGPSGGNYTYVMTGASSTPFIVSAVQEGLIDGDLEEIYQVLKKNHMPGGIMEKAGYEHDTNLGGGLKYYLEKGYVPYPLPEGKFGGHQDGGSLTMEYAYQDWTLAQFAKKLGHQEDYRYFLKRSENFKNVYDESTGWMRPKNVEGQWHEDFDPYDYKVGFIEANSAQATWFVPHDLAGLAQLMGGEEKAVQKLNRQFEEAIKLGFTAGTSHDVEEHPEYRRIPINYGNQPSIQTAFVFQKIGRPDLTQYWSRNVVRKTFSGLSPASGYNGDEDQGLMGSLAVLMKIGLFQMNGGTDEDPEYQIGSPIFDKVRIDLNPDFYSRSEFTIETINNSPDHVYVESAHWNNKRVNGNTINHRQITEGGRLVLQMTDAPVSTDDVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ2</accession>
    <name>A0A654DYJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylI</name>
        <name evidence="8" type="ORF">MARINOS108_11770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="27"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="42591" checksum="65011A4CBCCB2D52" modified="2020-04-22" version="1">MRMKDLKFLIISGVFFTLTMSCAQTEKKVGPTLRTAYADDFYIGAALGWGQILEKDSAESTLIRNEFSSLTPENAMKWMYVHPKPDTFNFEYTDKLVAMADRNDQFMVGHTLIWHNQTPEWVFRDEDNDLIDSTALFGRMKDHINAIMGRYQGKIGGYDVVNEALNDDGTFRESLFYQIGGVDFIYKAFEYAAMADPEAELYYNDYSMNRTEKCDGAVQLAKAIKAKGLRIDGIGMQGHWGLDRPTLEEIETSILKIGNAGLKVMITELDITVLPNPRNVEGADLSASFENNAEANPYKNGLPDSVQMALAQRYADLFELFHKHQDIITRVTLWGVHDGQSWKNNWPARGRTDYPLLFDRSLAPKPAHQAVLGVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK9</accession>
    <name>A0A654DYK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional activator Btr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="33604" checksum="1550A71F3E0A7586" modified="2020-04-22" version="1">MKRETLFQPFEIVTKTVDECPKLEHMHMFFELVYIMEGTGQQCINQNKFRYHPGHMFLITPQDCHSFDIETTTTFFFLRFNDIYIKQSGLWKDKIEQLEYILQNVSHKPGCILKNQTDKQLVKPMVDAIIREYVNRDLYNKELIEHLVNTMIVVVARNIAKYLPDTVGEHTEEKAMDILQYIHKHIYEPEKLRAKAISDEFGISESYLGRYFKKHAEISLQEYVSNYRVQLIEHRLKHSDLRVGEIANSLGFSDESHLNKFFKKATGLSPVAFRKEFRKEIAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL1</accession>
    <name>A0A654DYL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111382" checksum="0A762743A7D30AA4" modified="2020-04-22" version="1">MSLSDLDYSIFSNQFIQPIMKRPLLLLLFSVSVYVLHAQDNYSNEPTFHDPNAASLGKYVDIPVSYHTGVPNISIPIYTVKEGELVLPVSLSYHASGIKVNEVASSVGLGWSLSAGGVISRSVNGAPDEGIQRTGGKTNRNGWGYYTDGGLPPEIEDPANNCGSQWVNACKESCNVGCNCFEYFYDAAKGRADSEPDLFSYNFNGKSGKFYFDQSGGVVLLPRSDIKIEVISFPHSWKIVDTDGTKYYFGTTAATSKVYTYNPSGSGSIGNDTYSTSSWYLYKIESRNSDDNIYLTYEADDHGYGNRQSQSISMYHAQASLSGDVAGVSHLLNYTWVDGVRLSSIISSKTTISLIPGSVRQDVTQYGSPNGAANTVAKSIQEIQISSLGICKSFELNTSYFSSATGSSDYSFSDISDTKRLKLNWIQEKSCDGTLVNPKHEFTYYESTPLPRRYSLGQDHWGYANGESQQNHLIPRGLQLFYSPTPETYANRAPNFTNGQAYTLKSIKYPTGGTSEFIFEAHKDASNNVIGGLRIKTVQSKDASGTVVLSKSFTYDLPNLYDGDPMGDYVDDLENNLEWAQWNLMLNSEVRLGKRITSSPKSILSSTQGYHIGYSKVTVTNSDGSDEIYNYTNQNPIPVTFEYPSPPPFQVIGIGRLAGSEYRDADDNLVSSEVNYHGTALGAAFDGIRISVETSPDGTSGCALGYSYIVKKAYSYTSKYSRLEQSTVTKDGVTSITNYEYGNNHNFPTAIISTNSNGTVERKEISYAPDLSGSTYTTLVTRNVIETPIIEMQKVDGFPVSKVERSFSVAGYDIYPETTEYYPTGQNESSIYHYVYNSNGLIETHKEDDKRVAFWWEGPKQISVARFEGAPIASVYYNSFEEVAGTTGTAKTGTKYYNSGSYVIPTAYRPSGAGLKMTFWYYDGTWKFQSETAYSSTVTKSGATRLDEIRVYPAGTTVTSYVLGYNAQPITVNDPNNVVTTFEYDKLGRLKQKKDEAGNILQAYDYNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP0</accession>
    <name>A0A654DYP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted O-methyltransferase YrrM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21640" checksum="5DA537842CC8C76E" modified="2020-04-22" version="1">MNQSNILDIPRVYPKLEARCSEIGFTMPSDIYIGTLLKSLIASKPNARVLELGTGMSLSLAWMVEGLDEHSELISIDNDPQLIKIAREFFANEPRVSLVCTDGADWIKSYQDGAFDLIFADAWPGKYSELNETLSLLKVGGIYVIDDMNPQPNWPEGHAAKAEKLTAYLESREDFTITKMNWSTGVIICTKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT6</accession>
    <name>A0A654DYT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding transcriptional regulator NtrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ntrC</name>
        <name evidence="8" type="ORF">MARINOS108_12115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="148"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="448" mass="51188" checksum="58872A91BF31916F" modified="2020-04-22" version="1">MGQKPFTIFVVEDDDWYRKLLHHNLTLNPEYRVETFANGEAFLKQINEKPDVVTLDYRLPDYNGEDLLKKIKAADPGIEVLIISEQSEIETAVSLLKAGAYDYITKTEDIRDRLLNVVQHINKNRSLKTQLENLQTEVAQKYEFETSIIGQSKEMKKVFQMMQKATTNNISVIITGETGTGKEMVAKSIHYNSPRSKKSFVAVNMSAIPKELAESELFGHEKGAFTGAANRHAGKFEQAHGGTLFLDEIGEMAPELQAKLLRALQEKEIVRVGGTEPVKVDCRIIAATHRNLLDEMKKGAFREDLYYRLFGLPVELPPLRDRENDIVILAKHFAESFYKENDMPPKTFTKDALKKLMTYSYPGNIRELKSIVELSVVMAEDHEITAEDITFTQSNPITELFDEALTMKDYELRIVKMYLKNHNDDIKKVAELLDIGQSTIYRMLKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT8</accession>
    <name>A0A654DYT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026341">
        <property type="entry name" value="Bac_Flav_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04131">
        <property type="entry name" value="Bac_Flav_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024905557" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="905"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1409" mass="152279" checksum="C6DE4BDEB61FCBB6" modified="2020-04-22" version="1">MSKILRSGVIKFILCFFMVPSAVVAQNITETQWYFGNSPDAFVMDKNGRTPNIVDNQVTPFGTNGSTVISDQEKGNLLFYSDGQVIYDNTHQALPGLGAATLSADLTIIQPVVSCPFPDGTPQYYIFTNTGSAIEFTVVDASLPGNSTILQFPLGDVSGAINQPTGLNNPGELMKILESADGQRYWLVTQEATTLNFQVTEINSTGLGATTSYDVFPAALPRFQATALAIKTDTTGTYVAASPKNANRNTILLDFDPLTGALAFNQQVIGSGFDDSGTSVIYDTEWSNDGSKLYISRTGDDTNQGNIYQIDFADTVNANPPVTPILNNAYFRSYGLKRAIDGNIYHLYQRNSTAPFILGRINRPDSAAAIGVFYDSLVFTNNFNGTQFPEFAPAYMPTNFFTMSFTYLDSCVESATKFIALVDPLPNNYFWNFGDGTGSVGPAPIHTYDLASGYFVTLTAELNGTFQSVTLPVDILPGDSAVDLGNDTTICVDEILMLDAGDGISYLWSTGELTQTIEVDTAGTYWVEVTGPSGCTSFDDIVVTEYGVQRQVFNQWYFGEMAGLDFNSNPPAPLLDGMIFSEEGCATMSDDNGQLLFYTNGSTVWNKDHLVMANGQGIGGDSTAAQSSIILPFPDDNTMFYIFTTEEVYGDFTFNLKMSIVDMKKDTARGQVLIKNIPIIECSTERVTASGFGGTPWLLAHEYGNNNFRAYQINTNGVIGTIHSSAGEPHVFQSEPRATGYMKFSPAGDLVAVVVPGSPNYIDLLNFDLTTGQVSNSRLIDIEEAGEAYGLEFSGDGLKLYVTTTGVNSKLIQYDLDSINSQNPAADIQATKFDGYGATLPGYGALQRGPNGVIYLAIDGQTQIGSISSPGGNDLTASYQETNTDLGGRTSRLGLPNFTQQITAAPQQPGITTEVACAGQPTSFTAVGRDSSIETYSWDFGDTTGVVTDQNPQHTYLNPGTYIVQLTLSNRCDMDSVLRDTVEVFNIPLLPTVPTDTALCGGPVTLFAWDTDDPGLNYYWSSGDTTRAVTFTAPTIVNVAIINDDGCSSDTLTVFIGEDESFIDLGPDRLICQNDTLILDSNDPGPNYTWYRDGVVVGDQRTQLVASGSPGDFLYAVEVINDFSGCIYRDTIQITVQGGPQAIQSNILTPDCGQANGSFTLDISTTGNYSYALSGPVTAGPLNFDGPGTTPAFTGLPAGTYTSTVTNTVTGCSTDEIVLLEDNAPFEMEAVGENACALTGDISVRFSNRIPARVEINVVNEAGNNVFSSTETLTRSTFTINDLDSGLYFVEVRDTNPPNCIQSDTVRLSVSDECYRTIFVPNAFSPNGNGANDEWFAFPNEFVDQFQVYVFNRWGDLVFYSNNKNFRWDGSFAGGEVPMGTYAYRMLFTSTLEPEKGTFEQYGSVTVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU1</accession>
    <name>A0A654DYU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="407" mass="46769" checksum="15732F4FCD4A9299" modified="2020-04-22" version="1">MIKRLSIIPILFLTTTVCWCCTIFCARDQHGQMWAGNNEDFYWYNFSTHIQIVTETDSTLAFIFFDYPNNNFPQGGINEAGLFFDINLVEASEVKNVPFKKVFPGSSSDLMLHMLGRCKSVHEVIELFDSYSLSEMNTAQIHLADKQGNKGIITADSSWLSTQSFQVSTNYNLCHKDDDYKRCWRYPIATSLLKNSEPSFELFSQICDSTAQRQGAFTIYSNVHNLTTGEIWLYYAWNYNNPYKTSFKEMTQLGDTTILFRDLFPEQPVVQAYNKYKSYGFKSGLDVLKNIKNLALRKEKLKLISLDALFLFDFLLQSGRIETTDDDDLISEIIDASDDTELLMLITNQKVSQHNKEMARKKLESIQKSRFNDTLALLAVASIGFIVILIFAFKRKTNKQLTNAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYU2</accession>
    <name>A0A654DYU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024976466" evidence="1">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21900" checksum="4E85F49B1A594633" modified="2020-04-22" version="1">MKASQMPLLILLLCSLSVLAQEQDRSKAKYGERTALKVEYFGELVLHPGLSLGLDYTMVRNSWVTLHWDTDLGGYWHRWNNTSVFLKTSFGSRFAVGPVFADINLGVGYMHSWAAGVMYQRTENGGVEKAANLGHPHFMPNASFLLGWDGSRRKALPWTIHIGPEVYLQYPYNHIFLPHVAAKIGFTYKLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV0</accession>
    <name>A0A654DYV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Y1_Tnp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="22209" checksum="DA2C86C383C2DA04" modified="2020-04-22" version="1">MLIRFNNLVDTFKVHDIRSSGTSLYHLRYCSVGGALSRPSYKDIIVESLRYCQNEKGLILYAWCVMSNHIHLVVAAQEGCNLSDILRDFKKFTSKKMLKEIDENLQESRKNWMLWLFRSAGEKNSNNVKYQFWQQDNRPIELSTNAMKDQRLDYLHNNPMTEGLVCEAEYYPYSSAMDYDGSKGVLNVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX1</accession>
    <name>A0A654DYX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual-action HEIGH metallo-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024653">
        <property type="entry name" value="Peptidase_M10/M27/M57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12388">
        <property type="entry name" value="Peptidase_M57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062693" evidence="1">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="29959" checksum="33EC6010606A161E" modified="2020-04-22" version="1">MSKLKFTLLSTVVLLASFTLVTSCTQDEVVPNDDAISDEISAKFEELGFDVSDMRKVNTTNPLTKETTSGFLLEGDIMIPLAQMESMLSSELFHQGPCGEQYRTNNLVSSPRTISVIGYTGGSQALDNTMRTALSWAVDNYNALNIGLTFTLSYGTNYGSKDIVVYKGGSGAGGSAGFPSGGNPYKYVQILSGTSSYGTNVTEHVITHEIGHCLGMRHTDYFNRSLSCGSGGNEGDGGVGANHIPGTPTGFDANSIMLSCFSSSEDGEFGSYDVTAFEYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ47</accession>
    <name>A0A654DZ47_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 16" type="primary">murC</name>
        <name evidence="16" type="ORF">MARINOS108_110109</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="15">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="14">
        <location>
            <begin position="313"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD15952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="461" mass="51972" checksum="92546E38BD68DEAD" modified="2020-04-22" version="1">MKLKDIQSVYFIGIGGIGMSAIARWFNQRGVKVGGYDRVDTNLTTRLSLEGMWVHYEDNPRNIPAEFMDKEKTLIIYTPAIPKKHEELRYFQKKKFIVMKRSEALGIISKRHYTVAVGGTHGKTTTSSMVAHLLNQSEKGCSAFIGGIMTNYDSNLIVGGEDAPVVVEADEFDRSFLWLSPNYTVVTSVDPDHLDIYGDEEQMKDAFGEFVKLSGEDGSTLIHHAAAEKINMHLENLYYTYGIDKGDIQAKALRAVNGMFVFNYHGNEVIKDLTLSVPGFHNVENAVAAVRVALDLGMDPETIKAGIASYRGVKRRFEYIIKDEKLTFIDDYAHHPTEITAFLKSVKALFPRKKLTVIFQPHLFSRTRDFQTGFAESLSLADEIILLDIYPAREEPIPGITSQIIFDNITKEQKILCEKSELMEVIATRNVELLCTVGAGNIDQEVPKLKSYYLKKYQIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN5</accession>
    <name>A0A654DZN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="21644" checksum="EE954C5B2F03858D" modified="2020-04-22" version="1">MEPIPVKFSQTTLTELMIPSYANFGGKIHGGILLSLMDKVAYACASKHAGAYCVTVSVDEVEFLQPVDVGELVHLRASVNHVGNTSLVVGIQVTAENVKNHAIKHTNTSYFTMVAKDDDGSLVKVPPLRLESMDEIRRFIEVIKRRKLKAEANNKMQKEQSNFVMAEDFPLLRGQRCETRLVGDDDHLNDLFAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP0</accession>
    <name>A0A654DZP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024792580" evidence="2">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="397" mass="42838" checksum="B4C1ABA0B26DB35F" modified="2020-04-22" version="1">MRKALILLPAILLSTTLWAQWNGNSTTDPIWRSGAVGVGVSSPTEKLDIEGTIKIRNNSDSWRLVTNSGGSFSIKQTGFSGALNIYKSGASNNDLLNLYNGMVGIGTTTPDFPLQVRTPLETTDPISYGFDVTRVDNEARGLSIGMATDNSYSVIGAHNADLKLGHTFGVGAGGQPVFFADITIKHTDQSIGKVGIGTSTPSQRLDVNGNIALNNYQILSQGGSSIGFGTGGIGNEDDDITIDIVNDGELELHRAGINLLSIGNSILLDRTNSVNVGIGIEDPKSKLAVNGQIRATEVKVLANIDVPDYVFESDYQLLSLKETKAYITENKHLPEIPSATEIGENGIDLGDMNMRLLKKIEELTLYQIELLERLEQLESKSIEFDKLMGRIQALENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP8</accession>
    <name>A0A654DZP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_110011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD15835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="560" mass="62527" checksum="72F2EAC0DC68B03B" modified="2020-04-22" version="1">MNYFDLIVLFGTLIFIVAYGVWRTRGQLNIDGYFLGDKSMRWGTIGLSVMATQASAVTFISTPGQGYESGMGFIQNYLGLPIALIIVSAVFIPIFYRLKVYTAYEYLESRFDLKTRMLGALLFLVQRGLAAGITIYAPAIILSSILDWDLTATILVTGTLVIIYTVSGGTRAVSITQKHQMAVIMGGMFVAFFILISYITDYVSFGDAVSIAGKLEKLNAVDLDFNFEKRYTIWSGLAGGLFLALSYFGTDQSQVQRYLGGRNVTESRMGLMFNAVLKIPMQFFILFLGVMVYVFYLFYAPPVHFKEVSVQRLNDSAYKTEYQDLERTYEGLMNERKALALDFSKAPHAESETIAQELQKVDNESVAVRQQVKDLLVKMDPEIETKDSDYVFLTFILTFLPHGLIGLLIAVIFSAAMSSTSSELNALSSTTTIDFYKRLINKDDKYHLFISKALTLVWGIVAISFAVLAKNSENLLEAVNIVGSIFYGTILGIFLTAFFLKYVKGNAVFWAAIIAQTSVIVFHFLTIYGVFTLGYLWYNAIGCFLTIGLGVLFQTIQRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ5</accession>
    <name>A0A654DZZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="286" mass="33710" checksum="65B9FCB2AB64C9CE" modified="2020-04-22" version="1">MARIFYYLIIKPLSFLPMWALYVLSDLLYLVMRCGLTYRKKVVFSNLSLAFPDKPHEEIRAIAWKFYRHFCDLLAESVRLFSISKEEAIARFKVVNPEVLDALALQSKSALLVGGHYNNWELFAVATAPQIPHQLLGIYTPLTNAFFERKFSESRSKFGLVLVPKKMVKETFEHYRNHLTVTTFAIDQSPRKSQKVYWTRFLGQDTAVHFGAEKYAKYYHYTVVYGSARKVKRGYYELRFELIEANAPEAHEGSITERMTHLLEHQIHESPEYWLWTHKRWKLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E062</accession>
    <name>A0A654E062_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="14714" checksum="F226CFCF30352CF0" modified="2020-04-22" version="1">MDISSLNWLAVIASAVMTFVVGGIWYGPLFGQTWMDEMGFTEEELKEANMVKIYGIAFVLELIMAINLAMFIGEASVSEGALYGFLTGFGWVALAMGVNALFSRSSFKLWFINSFYFVITFTLMGVILTAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E091</accession>
    <name>A0A654E091_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="17952" checksum="EF72963F1D5C6982" modified="2020-04-22" version="1">MDSFSLIMGIIFALAMFGPIAYLVWAGQSRTKRMKNILKNLSQDHAFQFAMQEVWGDKALALDSIHKVFVFQSRQTGAEVNKVIALGNATYCKLDKKKDKVQILIGIQDILGLYTETISIFDTQYDDPSEAGFHALLGEKWKESIRSVIMSETTRPSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A0</accession>
    <name>A0A654E0A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="10879" checksum="2D5D4423DE5FCF4B" modified="2020-04-22" version="1">MGILSSLFGGGSKELQALKDNGAVVIDVRTPGEFKNGHVKGAKNYPLQNIGSKTQEIKRLNKPVILCCASGMRSGQAKGILKSAGIECANGGSWTKVDRLYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C4</accession>
    <name>A0A654E0C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="71"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="40078" checksum="29DFE3E1A548B925" modified="2020-04-22" version="1">MKGSRFYFLAILIIAGCTPPQEKEQSTGRTLNTQVKFAEKFTVEENAIIVKEPWPGAVAPISYAPDTPPQRVVVTSTTHLAYLEMLDVEDRIVGFPSTQYISSPVIRKLVNDGKITDLGPDGSMNLELLISLAPDAVFAFDMGSESTTLDKIEESGIPVFYNADFLETSSLGRAEWIKFFGAFFDKEKEADSIFTSIVQRYDSLKTLAADAQNQPSIVSGVMYGDTWFLPGGQNWAAEFYRDAGGRYLWENDSTSGWLEISFESVFEKAGEADFWIGTSTFNTKKELAGQDTRYTHFKAFKVDEVYNYNKRLGPTGGYDFFESAYTRPDRVLADLIFILHPELLPDYDTYYFQKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I4</accession>
    <name>A0A654E0I4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hpt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_12114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="350"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="588"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="728"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="2">
        <location>
            <position position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="828" mass="93625" checksum="78073D8C1C9EC04D" modified="2020-04-22" version="1">MAFDITLSGEERLFVGSLQISVKRSHIANFLGILLIILTISLAGAGFITYRNLEEIVSKLETDDRSNENLLQYKEILVNLHDMENQVESYELTSDPKYIERYNRSISRVFARVDSINGLNQTDTELLVFNDSLRSLINEKTYTLNQLIDFRSNQKQDDFKELEGFLDAISANPKPPAQTKKDTTGLSAPEEKKGFFKRLLAKKPEPVATPKVNQDSIILAEKKQYHSQINSKVDQMRSSQRLVSQRQREKEMNLLSAHFGIQNQIIDLVTFLESRETTKVKIKAIKAKELANQTSQQITLFFSLATLLLLSSVIIMVTYVQRNGRYQELLRESKKSAETLAKAKERFFANMSHEIRTPMNAISGFTKVLLRTELNEEQKEQVEIIHKSSEHLLRLLNDILDFSKLQAEKLQLETTPFSIRQVCDDSITLLKASAAHKGLKLYSELDNVPEYVLGDPHRLRQIILNLLNNGIKYTEKGEVALLVSGERKQNKFHVALEVKDTGIGISKNHQLRLFQEFEQANQSSFSKGTGLGLAITKRLVNLHHGSIRLDSKEGEGTSVFVKMAYPLTDKQPVEESTKETKHDFQGVHVLIADDEPFNTKLLATILSKKQITFDVAHDGTSALKLAMTKPYHMLLLDLKMPGHTGWELLEEIKSTAGPNQNTPMIALTATVSSLDKSRGTTFHFDHIMRKPFEEAELFDSIANALNIAPPEDSQKRVTDLSSLMQMGDQQFVEDMVETFINGAKEGLQQISTALKNQAYEDISLVAHRIVAPARHFKAGQLVDLLKNLEKRADDRDSTITEADLNHIRQELDQVIASLRSALQAQIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V1</accession>
    <name>A0A654E0V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024788738" evidence="1">
        <location>
            <begin position="21"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="530" mass="57230" checksum="69A791DDEFF20233" modified="2020-04-22" version="1">MKKSLSALLILFCLSCNVNDLDFDNLKGPTLTSEVALPLGDISYSMRDLLNEIGDKALQLDEDSTSLLKLTYFDSAEFNKGEDVINIDDISNQARIGIPALGPAPESLQAVIDTILVFSYPAENNEALDSVFYNGGSLVLSLNSNMGSDVNFTFDITNTRSISGNEPVTFAGSMGGFGNYEESRDLDGYKTLLSTEGDSNTFQVNAQITVFLGPGESTSPTDYLNMTLSYLDQTFSILYGKFGQDTLAVGNEVLNIAFFEDLGESGFKFGDPEINFHFESTFGVPMGIVFKGLYGADSSASGMDTTYLSGSATVTPQVVEGAKSPGQFVQSTVSLNSQNSSLRDLLAASPRSIGFNLTGIANPDDPTQQNFVMDDSYISTAIEISLPMELSLKDVTREIDFSLGDGLDFDEAESLTMRIISLNGLPFSARLEVEIRDKSDSTLHTIPQALVLETPFIDKAGLVTQARSHVEDIHLTAEGVDALRVGSKVVLRIILNTPATSGTRDVYVKILADYKIDIKVAVVGKLKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V5</accession>
    <name>A0A654E0V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="3">
        <location>
            <begin position="102"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="247" mass="28427" checksum="31B2777E3B925822" modified="2020-04-22" version="1">MPNSPYIKNRRLRVFGGPNGSGKTTIIELIKSSFDVGFYINADDIEKEVSLSGKFDLSSYNLDSIDPKLFDSFIQNHGMTKKAGSMGYKLDMRLNEENILVDNSAEVSYEAALIAEFLRQELLNKGKKMTFETVMSHPSKIDLIKRANQNGYKTYLYFICTSSPKINIERVNLRVKKGGHHVEKELIEKRYYNSLELLKETVSNTYRSFIWDNSGKEPKLILEVYNGKEVIAKTNQIPYWIHQYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E124</accession>
    <name>A0A654E124_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024811234" evidence="2">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="477" mass="54862" checksum="7381B552824947FD" modified="2020-04-22" version="1">MRLKWIILFLLPTFTGFSQAPDSAALSLGDIFAIAKANHPIIRQAKLQDDMAVAELLYTKGQFDPKVQSNYNVKNLNGTKYYQKFNNALKIPTWFPLDPKFEVYRNQGAYLNPESYVSSSQDYWQVAAGVSLPIGKGLFIDERRMLVTQARLYSGLAQAEKIKLINKTLLTISKSYWDWYLAYKKYELTSSAIEIAREVLARTQLDYEFGEAAVVDTIQAKITYQGRQTDFEKAKLELLQSQLALSVHLWSEEGIPLELSSGSFPVSEDTDFMVPSDSGFQILVAWALNNHPDLQKLSTKRDQLEVEQRWNKESLKPELNLSYSLIDAPFNADGFESPDWENNYKLGVDFSIPILLRKERGKIQKNRVYQEQIEFEMSQTRLTLSNQLQSTYAELKTNQTLAQQFSNMSQGYRQLFEAEIFNLESGESDLFKLNIQQEKYIGAQIKALEALVKFEKMRYQLPYEVGLPNLSYQVLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I6</accession>
    <name>A0A654E1I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="496" mass="57760" checksum="BFC99105DAD61689" modified="2020-04-22" version="1">MPKEIFEFKLIFGLKLKEIRNEKGISYQELREKTGLSLSYLSEIENGKKYPKGDKIMILAKALGVSYDELVSLKVPRKLEPIVNLIQSDFFKAFPLEQFGLNPQKLVEIISYDPEKINAFVNTVLQVSRNFELKQESFYYAALRSYQELHQNYFADLEEAVEELHLEFPELKEIPFNEKLLTGILLEIGVRTGMDELQKYPSLRNVRSLYDEKQRLLHINRGLNSGQMNFLLGREIAFQWTKVKNRPMSTPPYGDHTFEEILNNYRASYFSAALMMPQEEVVRDIRAVGDMKVWDPKVLLGFLDKYDVTPEMIMQRLTNILPAVFGYENLFFLRFVGKGPDYFTLTKELHLTRLHNPHGNELNEHYCRRWISLDVIRDLYKARESDPDIKYLAGIQRSFYHGTTNEYLCLSIAFPNVSNPEEAVSVTIGFLVDGALERRIKFLRDPNIVRREVNTTCERCPIMDCKERAVEPYVHAAKTEEHLIQEDISTLLGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K5</accession>
    <name>A0A654E1K5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4653" checksum="1B917BA08E56BE5E" modified="2020-04-22" version="1">MSLLFGNSFLNDNSTYEKIVARVRTHLLTLKVSRSLAIMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P4</accession>
    <name>A0A654E1P4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ahcY</name>
        <name evidence="9" type="ORF">MARINOS108_120525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
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        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
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        <ligand>
            <name>substrate</name>
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        <location>
            <begin position="160"/>
            <end position="162"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="223"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
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        <location>
            <position position="349"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="435" mass="47791" checksum="83018D1E471CC6BF" modified="2020-04-22" version="1">MIEEKLNYKVKDINLAEYGRNEIRLAEAEMPGLMALREEYGPSKILKGARIAGCLHMTIQTAVLIETLVELGAEVSWSSCNIFSTQDHAAAAIAKAGVPVFAWKGLNEEEFDWCIEQTLFAFEGGKPLNMILDDGGDLTNMVLDRYPELVEGINGLSEETTTGVHRLYERMRKGTLPMPAINVNDSVTKSKFDNKYGCKESLVDAIRRATDIMLAGKVAVVAGYGDVGKGSAASLRGAGVRVIVTEIDPICALQAAMDGYEVKRMVDAVPRADIIVTATGNKDIIRGEHFKLMHDKTIVCNIGHFDNEIDVAWLNGNYGSTKVEIKPQVDLYNIDGKEIILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELWTNVKNYENAVYTLPKHLDEKVAALHLAKIGVELETLSQEQAEYIGVTVAGPFKPDTYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E5</accession>
    <name>A0A654E2E5_9BACT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VXD18146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="16640" checksum="D934A0076D29E20D" modified="2020-04-22" version="1">MTMERITAKELPKGWFDTMLNTEGYLKKAGIDQMIYHLVKFRASAINGCGYCMDMHAKEAAKDGETAQRLYLSQVWREATCFTPAEAAALHLTEALTAIGHSDLESAYTHASEHFSKVEIANLVLLICQINSWNRIAITFGYEPGSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F5</accession>
    <name>A0A654E2F5_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="VXD18776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6568" checksum="8978FF743177A0FC" modified="2020-04-22" version="1">MENMTEQELIECAERIVRHLEKNIVKHRDKPLLANKLASMNKYIHMCYIQRVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U8</accession>
    <name>A0A654E2U8_9BACT</name>
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        <submittedName>
            <fullName evidence="6">Peptidase</fullName>
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    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
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            <taxon>Cytophagales</taxon>
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            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
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        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF5118"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032534">
        <property type="entry name" value="EcxA_zinc-bd"/>
    </dbReference>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn_MMP-like_bac"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF5118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024999550" evidence="2">
        <location>
            <begin position="16"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5118" evidence="5">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5117" evidence="4">
        <location>
            <begin position="85"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4953" evidence="3">
        <location>
            <begin position="404"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="812" mass="91035" checksum="E138A53A2D59BC08" modified="2020-04-22" version="1">MRTLYFTLAAMAVFACSPKSTPSTSSSSYETTLATYKKYEGFFDFYWDADKGKVFLEVENLGEEFLYVNYLAAGLGSNDIGLDRGQVGDNRIVKFERSGPKILLIQPNYGYRAVSENKEEVRSVNEAFAQSVLWGFKVEKEQNGKVLIDITDFLLADAHGVSETLKKSKEGTYTLDASRSALYLEMTKNFKDNSEFESTITFKGTPTGSNIRSVAPTAESITVRMHHSFVRLPDDEYVPRKFDPRSGYYSSSYQDYATPIEEPLVKQLIFRHRLEKKNPEAEMSEAVEPIIYYVDKGAPEPVKSALIEGASWWNQAFEKAGFINAFQVYVLPDSIDPLDINYNVIQWVHRSTRGWSYGSWIADPRTGEILKGHVSLGSLRIRQDFLIATGLLQPYEEGKEPSDEMLEMALARLRQLAAHEVGHTLGLYHNFAASADGRASVMDYPHPNILLGENGEIDLSDAYDTGIGEWDEFAIRYGYSVFKENEDSYLQDIIDEWISDGYHFIMDSDARPKGGAHATAHLWDNGENAATELVRLSAIRAKVLSTFSEKAIKTGQPISSLEEVLVPMYFLHRYQIEAAAKLVGGQHYTYKAKGDGLPLPQKVDATTQQAAIDALVGTLSPTFLGLPPHLLDLLSPKVPGYGRTRESFKSNTGVTFDPVAAAEMSAEMTLQMLFQPERIERITQQNLQKSTFPGWKELMSRVNDQTWNANYPDGLAKEIKMVVEKRVLYHLMNLSVSSATEMTKALANFELERLVKTISTKMKATSDPLISAHYAHSIRLYQQFLEEPGDFKLPSTLSPPDGSPIGMDCMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E349</accession>
    <name>A0A654E349_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024851616" evidence="1">
        <location>
            <begin position="29"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="32141" checksum="EDA55216C7E5035D" modified="2020-04-22" version="1">MSINHCSHTLGVALLLLSALFLSNDAIAQDSTRYQIQTRDGNTYYGHIVQKEIEYILFQTDNIGQITIKFDDINVIRRIGKDVATERYRESNASYHAPEVYLFRSSGFGVKKGEAYYRNAWLILNELNIGFTDHFSLGLGMMPFVEGSLPVWITPKLTLPLLKDKVNFGIGSLNGVALGESQSSFGLVYGDLSVGGPSTHISLGAGKAYEEGELNPELLITFSGAVKISKNLTLISENYTLQDFYLYSLICHQNFSAVNIQYGLLIFDTDFGNLTLPWIGLVVPIKTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A2</accession>
    <name>A0A654E3A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="328"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="809" mass="90371" checksum="32D3FB10CE456749" modified="2020-04-22" version="1">MFRNYLITALRNLKRNKVYTLLNMFGLALGIGCALVIYKVIQFETSFDKHQENYESMYRVVNQNIYPDRVEKGMGTPHPLGPALKADFPEISDVVRTNYQYGSQLNTYDENGEMHKFLIDEGIVFTEPSFFELFTVEWVAGDQAKALTAPGSVVICRSEARKLFGLKEGEEHLALAKLINYGNVMDFKVVGIIGDPPSTTSLPFSYLFDYESQGGEINPYFGEGIRWNSTSSNTNTYFLPGAGFDRAAFDQKMIAFVEKYRGEGESEETRYVAQPFSEIHFDKEYDSYGGTSSIEFLIALGLIGVFLVLTACINFINLATAQAANRAKEIGIRKAIGSMSSQLVFQFLAEIALITGFALMLALAVAEIMFNLLREIIGQELTVGLLQSPDSLLFLLVLFVVVTFLSGLYPSMLLSRMNTVDALKKKITNGQHSGGLSLRKGLVTLQFAISQFLIIGTLIVSSQTDFFLNKDLGFQTKTILSSYVPERDAVKLERFRQMMLSSPAIESVTFSLSEPTGNSNSKSSFNYAPLESPKAYHGNFKAVDPYYISLFEIELLAGRDIREGDSTNVVINQKVADLMGFKDRYDQAVGETLSTGWNGDKKVVGVVKDFHAYSLAEDLDYILFIHAPRLFYTLSFKTTSPAAITEAKAHFEQTWEQIFPKYVMEYDFYDKTLAQEYEDVMKITALMKVFAVISILIGCLGLYGLISFIAMNKTKEIGVRKVLGASIFSILSMFSREVIILMTIAFSITTPLAFYFLSQWLDTFAFSISIGPEFFLLSFGVTMLIAIVTISHKTISTALINPAETLKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A8</accession>
    <name>A0A654E3A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024928890" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="UnbV_ASPIC" evidence="3">
        <location>
            <begin position="527"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122738" checksum="81913C859A24A567" modified="2020-04-22" version="1">MTCTKFFTSPLIVLSLLVMACEPNSLDQGLLFKEMSIDQTGVSFVNEVRDQEDFNIFNYRNFYNGGGVAIGDLNNDGWPDIYFTANMAANKLYLNTGNWSFEDITEKAGVQGTRSWSTGVTMADVNGDGWLDIYVCNSGDLEGSNKTNELFINQGDLTFVESAAVFGLDDHGYSTHASFFDFDGDGDLDCYLLNNSFKSIDRVELFTQRRELRDTLGGDKLLRNDNGLFTDISAEAGIYGGAVGFGLGVSVSDLNGDMRPDLYIANDFWERDYLYLNVGDGTFSEEIVSRTDVVSGSSMGADVADLNNDGFPEIFTTEMLPPDNQRLKTMTRFDETNVKELKVRADYHIQVLQNCLHFNDGNGNFQELAALANTEASDWSWGALIFDMDNDGWKDIFVSNGILRDITSMDFASFASDRENIKKIVQKEGKLNVNDLLAYLPSTKISNYAYINQRNRTFINQADSLGLGIPSFSNGSAYADLDNDGDLDLIVNNINAPASIYQNQTDTLFGHAYLKVKFQGPEKNPFGIGARVTVYSGDKRQRLENFTSRGFQSSVEPVVNFGLGSLQRLDSLEVVWPDLKRQTLRDLVVNTVLTLSYPDADDTFRQTEPGAQSLYSEVTQTTLEGNYRHKENDFNDFNHERLLPRKLSTQGPRVIEGDVDGDGKDDFILLGAFGDPDKVFLQESNGRFKQKPQGSLLRDSIFESTCGVLFDLDQDGDLDLLIGSGGNEFNRGLDAHVLRYYDNNGHGVFNRSVERAPRAIGNFSCILAEDFDQDGDQDLFVGGRVIPGNYGLIPRSFLFRNDNGLWTNVEPQSLGGAGMVTDAVWSDFNGDDRKDLIVVGEWLPVSVYLNNGQGLEEAYAIPGTNGWWNRIEAVDLDCDGMDDYVLGNWGLNTKFKASIEKPLTMYVNDFDKNGKSEFILNWYPQVEDQSYPFASKMDITGQIPGIKKKAVTYEQYAGSTYETLFDEQQRAEAASYSVSLLQSAVLWSNDGDYQLEALPLEAQVAPIYAIVADDMDNDGIKDLLLLGNFHGLKPEVGFQSANKGVFLKGEGNRAFTYVTNAQSGITVNGEVRDASLLDIDGQKAILVARNNQEALLFSRAKREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C1</accession>
    <name>A0A654E3C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase HipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017508">
        <property type="entry name" value="HipA_N1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13657">
        <property type="entry name" value="Couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03071">
        <property type="entry name" value="couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Couple_hipA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="104" mass="11994" checksum="5B0B564095D70203" modified="2020-04-22" version="1">MRKAKVFYQDQWAGTLTEDDEGYHFQYESEYFAKKGEPISLTLPLQEKAYQSNILFPFFDGLIPEGWILDIVQKSWKVNEKDRMGILLVACKDCIGAVSIEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G1</accession>
    <name>A0A654E3G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="12456" checksum="1AB13C2ED570068D" modified="2020-04-22" version="1">MKRESIGELEELVLLTVGALINEAYAVAILDELHQQANRLIDVTAVHSVLRRLEKKGLVSSEMKGATQERGGRRKRYFLLTQAGRQVLEESMAVRMELYQKLPKLTFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H8</accession>
    <name>A0A654E3H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="205" mass="23281" checksum="C011A03D796473A1" modified="2020-04-22" version="1">MRNIKILLADDHAIVMEGLKEVLSADEEISVVGCVQNGEEVLRFIKNNEVDIVILDINMPVMDGITCARHLKKEFPKVKIIILTMYAQRSFVEEIVKIGIDGCLLKNNTGKELIDAVLRVMGGRQYYDRIGTFNSQEEEVTQYKLSEREIDVIRLMSQGLTSIEIAEKLFISDHTVKTHRKNILKKLNVSNSSQAVQYCLSNQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T9</accession>
    <name>A0A654E3T9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">MEP cytidylyltransferase</fullName>
            <shortName evidence="3">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ispD</name>
        <name evidence="4" type="ORF">MARINOS108_20942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="223" mass="24457" checksum="760C5255D314FD86" modified="2020-04-22" version="1">MQKSVIIVAGGSGTRMQQSLPKQFIEILEKPIVVHTIEAFLAYDQSISVVLVLPSAHFSTWRALAERFFPNTTIHLEAGGATRFQSVKSGLRVINEGLVAIHDAVRPLISPQVIAESFLSAAQKGSGVVMVPLKDSIRRKVEGKTAAEDRTAFFTVQTPQTFQVAQIKKAFEQAELETFTDDASVYEHAGMLVSAVTGEYTNLKITTPEDLILAEAIMNQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W7</accession>
    <name>A0A654E3W7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="102"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="33552" checksum="49672C9E84BF6296" modified="2020-04-22" version="1">MIKESELKALVTLLEDDDEEIISHVEKKLMEIGTGVIPLLEQEWETNFNPLIQRRIEDLIHTLQFELFQERLEDWKVNREDDLLEGLWLVATYQYPDLDLEELRQQVHQLYVEVWREFREDLNPFDQVRVMNSVLFNRFKFRANTKNFHSPANSMVNAVLESKKGNPISLCAVYLLIARKLDLPIYGVNLPNLFILTYRSQQSDFYINVFNKGLIFSKEDIDNYLDHLDIPPQEIFYDPCPNIDIVLRCLRNLIVSFEKLGDYHKSDEIKTVLTKLDDKNIGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z6</accession>
    <name>A0A654E3Z6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RelA/SpoT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="402"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="733" mass="83832" checksum="89359D7339DB3A86" modified="2020-04-22" version="1">MIEVDLEEEKREIIRRYRKLLRHAKPILKSGDARIIKKAFYMSMEAHKDMRRKSGEPYIFHPLEVAQICVSEIGLGTTSIVSALLHDVVEDTEVELADIERGYGKKVASIIDGLTKIAGVFDQGSSQQAENFRKMLLTLSDDVRVILIKLADRLHNMRTLGSMPRDKQLKIANETIYLYAPLAHRLGLYAIKSELEDLYLRYTDGDAYRHIASKINATKDARNKFIRNFIKPIKDELNSQSFQYEIKGRPKSIHSIHNKMKKQNVPFEEVYDLFAVRIIVDTELENEKAACWQAYSIVTDYYQPNPDRLRDWISIPKSNGYESLHTTVMSGRGQWVEVQIRTRRMDEIAEKGYAAHWKYKESKNGDADKGLELWIGKVREILEQNDASAIEFVDDFRSNLFQEEVFAFTPKGDLVTMPNGSTALDFAFDIHTEVGAHCLGAKVNQKLVPLNYVLKNGDQVEILTSKKQKPNEDWLKYVVTSKAKSKIKDSLKEEKKQFVMEGKEVVKRKLKQLKINFTQEALLQLTDHFDVKTPTDLFYLIGKGKIDHSLIKKFNEKKEEEHKYRRVTDPKGMQSQIKKVREKDFDLLLIGEDMDVVDYKFAKCCNPIPGDDVFGFVTVNDGIKIHRTTCPNAAELLSNYGYRVVKAKWTSSQDNSFLAGLRIIGTDRMGLINDVSSIISGELKVNMRSITINTEGGIFEGEIQLYVSDTKHVDQLIGKLEVVPGVVSVTRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E402</accession>
    <name>A0A654E402_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative superfamily III holin-X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14504" checksum="A4A91A2BB7B5EA2C" modified="2020-04-22" version="1">MSYASKITYDMSVINKLVDKLSEYIRLKGEKLKLEIIAQVAKLLAHFVAFLTIAIIGLFLLIFLSMALSAYLNMILDSPHLGYLIVAGFYLVMLLIIFFLLRSNKIQKWLEALFVNLSETIAEQNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A0</accession>
    <name>A0A654E4A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="44987" checksum="5584DB67D4B4BD79" modified="2020-04-22" version="1">MVFAAPMALRYSIDERHCCAGCSIGLYLSKIIQKALISATVNMNKNIHVVIMAGGTGTRFWPYSRNNKPKQFLDVLGTGRTLLQMTFDRFKETVPSENIWVVSNEIYKDLLAEQLPELPSENILLEPSKRNTAPCIAYAAYKIKEKDPNGVMVILPSDHVIFKEAAFVEVIGQAVDHADDERLFTIGIEPHRPETGYGYIQFEESDEEIKKVKTFTEKPELELAEKFIASGDFVWNAGIFVWSVTAIINAFETYQPELAETFEEGSGIYYTPDEPKFIKSAYSLSKSNSIDYAIMEKSDSVYVVLGDFGWSDLGSWNALHEIKTKDENENVIEGNVITYDSKDNYILSETNRVIVAQGLEGYLVADFEDVLLICKKEDSGIFRRFVTDVKMEKGEKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D0</accession>
    <name>A0A654E4D0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_60045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="23151" checksum="1B7E537444AA5B95" modified="2020-04-22" version="1">MLNSLDDHAIMLKVKAGDVEKLGLLYHRYSRRLFGFFYRMTSDSATSEDLVQNVFMRMLKYKHSYSERGNFEAWTFHMARNVHKDHLRKNKRYSWQEDMSGWEAHLKHNDTQETFHQKTDELEYLARAMQALSEDKREILELTRFQKMKYEKVGDLLGITESAVKVRVHRALKALKENYLKLDGPALGSMSNQAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E3</accession>
    <name>A0A654E4E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="21909" checksum="7960B3E066A23B67" modified="2020-04-22" version="1">MKEIQYLSIQGSCAPSFWFKDHDAQNFRSLIESLTLSHSLIISSIYRTDVFFMAEEDRLDLIMRTWSTFKQHTFDQHLKGKFTRANNRKEAFELYFDTLFHLIKHPKHHERYRLRLNEIQRLESNNPILRALMECDMLLTEKYREQQVKYVSLATTEQVGQYIPSCENFSLLAHERLSKLNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P0</accession>
    <name>A0A654E4P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="35015" checksum="6C9583D6EF68B1EA" modified="2020-04-22" version="1">MRIAVIDMGTNTFHLILVEVANDDFRIVFREKVAVKIGEKGINHGMITDEAIGRALKTLKHFKEIIEKEKADQVFATATSAIRNAHNGNDLVQKIKDQTGIETRIISGLQEAEYIYYGVKRALPIGKMPALIMDIGGGSIEFIIGTDSEILWKQSFEIGGQRMVEKFQKSDPITNEQITSLKGYLKENLEELFEACTTFHPKTLIGSSGTFDTLSDIYRLTNGIEKAEEETEYPLTLEAFELIYSDLLLKTRAQRLEIPGMIPLRVDMIVVACVLIDFIISQLSLENIRVSAYALKEGVLLSTLHSLKKESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S6</accession>
    <name>A0A654E4S6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018266">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="144"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="351" mass="39593" checksum="AB98B4AE40F75AA1" modified="2020-04-22" version="1">MKTWKKKYDDYNLEDLLLDESFISWVQGGKEASSPWKSRLLESQKLSEEAAKAEEIIGQLQWREFQGDNKRIENLKDRIDIRIRASDVRDEFGAYQEKPASSNWYRLLAAACLALLLMGSIGYYLANQNPVVEKNLSQEVEVRNTRNGQKLMVHLNDGSKVKLNSGSTIKYQKYFSDTSRVIELQGEAFFEVARDSLRPFRVVAGGTVTEALGTSFNIYSEMGDPTKVSLVTGKVSVTSTSTQEQVLLRPGQMVKALAGSLGSVASYEYGEIAWKDDVLFFLRCDQGEVFEKLEKWYGVNFRIEGKLSGGWNYSGSFDGQTLHAVLTSIGYAEDFTFQIKNKEVVIKPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E553</accession>
    <name>A0A654E553_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="23943" checksum="04D71BD0B1CC8667" modified="2020-04-22" version="1">MEEVKRQFSEKALQDFKLIDRATLHNDESAFADLMSRYKKPVYHMILKMVRNVDDAEDLTIEAFAKAFKNLARFKKDYTFSTWLFRIATNNAIDFIRKKKLETYSLNTSFTDDSGESVNIDVEDAERTPDEEAINTQKIELVRMFVTKLPPKYQRLVKLRYFDELSYEEIATELEAPLGTVKAQLHRARELMYELVKDKKKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E556</accession>
    <name>A0A654E556_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_21001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="112" mass="12520" checksum="A53DA4598EA05333" modified="2020-04-22" version="1">MNYKHTTAGDQLRLVFNGDLIGENNGPELVELVNDSLTKGMKYCLIDISDVRYINSSGIGVLITLLTKFRNKGGELFLIKPSEHVQKLLIITKLQAIFNIVDTEQEALSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E574</accession>
    <name>A0A654E574_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5247" checksum="3F6F52C078FA7BC3" modified="2020-04-22" version="1">MILLCNPTVNLPILLAFMLLAISIFLAYDFQNAVHCGYCCGGWAVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Y2</accession>
    <name>A0A654E5Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_90054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="396"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="656"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="803"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="905" mass="102599" checksum="19472780FEC25E5D" modified="2020-04-22" version="1">MRSIIIWLGIFCFGFLFGCQAEQEQEKKFKVGFSQPIMKDAWRQAMFNEMQRQLIFHDEIELIFKDGDSQTSIQIAQILQMVEDGIDLLIVSPNEAAPLQPIIESVFEQGIPVIILDRRINSSKYTAYIGADNKLIGNAGGKYIARLLNGRGKVLEVYESLKITAFSDRHFGFREVMVAHPQIQIDSVKAIAKGESKYRELIANEQYDVVFAATDVAAKFAYDVAQEAYPEGRNKYYIGIDALPGTGNGLEMVENGILTASIIYPTGGDLSIDIASRILNGEPYEKENILQTLVVDSTNVKIIQTQARKILDQQTDILSLSDKLGVIQRVFKTQRTLTYLFALTMVISIIMTASVLKSLVEKRRINNELQSKNEQITQYAQQAEEATQAKFRFFTNISHEFRTPLTLIKAPVDELLERKEASLFKKDLKLIRKNTLRLLRLVNQIMDFRKIDNSKMNLRINEQPLIPFLKEIMDSFEKLAGDKQITFKLIHDNDQVKLWFDGNMMDKVFFNLLSNAFKFTNKGGSIFIRVETNQLSDEVRISVDDTGNGMTEEQVTHIFDRFYQGDQYRSLGTGLGLALSKEIIDLHKGSIEVESIPNKGTRFVIKLKTGKDHLDESMLALEEGLYLRSDESLFPADYESTEEPLIREKSEDGSGSILLIEDNDELRAYLKGRLGRDYFVMEANNVAEGIEMAMNEVPDLIVCDLMLKHESGYEVIRALKEDLRSSHIPIVILTAKSSTEEKIKGIRLGADDYITKPFDVAILCERIHTLLANRQKLREHFLHELPVDQKGVSNSRIDKKFVSEFTALVEANLADAGFGVNEIGHELGLSRMQLYRKVKALLGYSVNDYISNVRLKKAKHLILEGEHNISEIAHIVGFSTASYFSTAFKNQFGMTPSEFKSNHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Y5</accession>
    <name>A0A654E5Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pectinesterase</fullName>
            <ecNumber evidence="4">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_90025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031589733" description="Pectinesterase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="35363" checksum="08C27B81B5804248" modified="2020-04-22" version="1">MRKLYLFTLIIAISFNGLAQYATEIVVDKSGQGDFTSIQEAIYSTKAFPEQDITIYIKNGVYREKVTIFSWNNRLTLKGESTDSTRIVWADHFASINLGRNSTFHTFTLKVEANDVRLQNLTIINSSGPIGQAIALYLEGDRIQLINCSIQGHQDTVYTSGEGFRQYFKDCYISGTTDFIFGGATVIFENCTIVSRSNSYITAASTPKSSQFGMVFLKCRITKMDESVNKVYLGRPWRSYAKTAFIECYMENHILPVGWHNWGSTEKETTVSYAEYASKGPGAHMNERAMWATSLTPTTAANYQLEVIFNGWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E648</accession>
    <name>A0A654E648_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="347" mass="38713" checksum="D7CB87CE9F943275" modified="2020-04-22" version="1">MKRLLYSLLILLVLLTAIVLQILHSGGFFRKVAPGFEGNIIQKIKLPGAEDIAISRDGHFLIVSSDNRAARRDGQPEQGGLYLVDLREEPLSPKLLTERFEQPFFPHGISLLRLDSGRYQVLAINHVNEKHTIEKFLLSGDRLVHEKTLSDESMVSPNDVVATSANTFYFTNDHRHTTGTWRLMEDYLGLRQSNVVYSDGSSYREVAHGIAYANGINYDENRNLLFVASPRDFLVKVYTTNPGGELSLIEDIDVGTGVDNIEFDELGTLWIGAHPNLMKFASYASGQSEIAPSEVIQLTYRGTGDYDVNSVFLDDGSIISASTVAVPFNNLVFIGNVMDDELIVWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6T6</accession>
    <name>A0A654E6T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="78"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32059" checksum="99159AFD4B002BA4" modified="2020-04-22" version="1">MIAGWVVVGQVPRDTSYTVANTVAKVLRHYPNLDVQGVEPNDPESVTSTFDVAYKDLGYRSLVANLFIPKEKRVSAAILMIHGGGWRAGSPGLMTPMAERLAEAGYLVMVPEYRLSMEALYPAAIGDLKDALQWMRDRSRTMGMHTNRMVVLGCSAGGQLAALLGTTTDVQAIVDIDGVLAFKHPDSQEGSMAAQWLGGTYEEVPELWQEASALTHVSASTPPTLFLASKYPRFLAGRQEYMQVLEEVGTYTAVRVFEDAPHSFWLLSPWFEATVVEVIKFLNDTILEQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E743</accession>
    <name>A0A654E743_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CcmD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8365" checksum="9CB5DDE5BF0D37FF" modified="2020-04-22" version="1">MINLMYLLPNLLNSLGVVLSTILLQIPMADTFRSEGKIYVVLAVVLIILGGLFYYLLRIDRKLKKLEEDINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7U8</accession>
    <name>A0A654E7U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024810048" evidence="1">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="32350" checksum="1D8B0DDDBBE0A51B" modified="2020-04-22" version="1">MNVLKILKKKGIVVCVIMAIILSSCASGPGSPEIVVQDLQMKIPADEQVFKEELLAGEIAETKIEHLAYAGPTEQTISLSDEYVSMFLFVSGNGTLQADSMVYNLVPESIAIPMNDTDQVQFKVPEGEELHFLQFTKRLSAQDIEDLKNFPEENKYDLFFTRFEDCEPYTEKIKSPNTVSRTVLPADIVPRVSLGTVEAMGPDEVGAHEHPMLDQLFLGLSNNDVVVHADAASTAFKEFSLLHIPIGSSHWVTVGENKKMYYLWMDFFLTKEGQEWLKTHKPMSTDKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8W0</accession>
    <name>A0A654E8W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4101" checksum="D2C0BFDE38B57AFF" modified="2020-04-22" version="1">MKVGMIIDIVGLSGTAISPFPEVLSLTNKIKANDEKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAU6</accession>
    <name>A0A654EAU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ORF">MARINOS108_140018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="3"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="361"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="423" mass="46366" checksum="B0A4DADB6995D86D" modified="2020-04-22" version="1">MKRDDKLFALIDQEKRRQNEGIELIASENFTSLQVMEAAGSVLTNKYAEGLPGKRYYGGCEVVDEVETLAIERIKELFGANWANVQPHSGAQANAAVFLACLNPGDKILGFDLSHGGHLSHGSPVNLSGKYYQANFYGVEQDTGLIDMDRVEEKARQIKPKMIICGASAYSRDWDYERFREIADEVGAVLLADISHPAGLIARGLLNDPLDHCHIVTTTTHKTLRGPRGGLIMVREDIDNPFGLTTAKGTIRKMSSILDSGVFPGTQGGPLEHIIAAKAVAFGEALSDEYMTYIMQVQKNAKVMADAFVKKGYDLISGGTDNHLMLIDLRSKELTGKDAENALIKADITVNKNMVPFDDKSPFITSGMRVGTAAITTRGMMESDMEKIVDLIDKVITNHTDDEALADVKSSVNTWMNDFPLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBS2</accession>
    <name>A0A654EBS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041186">
        <property type="entry name" value="DUF3823_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024278">
        <property type="entry name" value="DUF3823_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12866">
        <property type="entry name" value="DUF3823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18003">
        <property type="entry name" value="DUF3823_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3823" evidence="1">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3823_C" evidence="2">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="32037" checksum="C11143482C8FDB19" modified="2020-04-22" version="1">MTNNQTDKEMSLNKNIQKMIRIPNYAAMLLLISLSACSLFELDNYDAPAETLKGEVVDVATGEPVLTDQGSEGIRVRLTELSWGDNVAPNPDFFCMPDGTFQNTRLFKGTYNIQVDGPFIPLLREDDRGVPLANETQTMEIEGVTKARFEVQPFLKVEWVGSPTVVNGKVRAQVKVTRGVSEEDFQSKIEPMGGYSDSFFNVTDVQLFVSYSSSVGYRARDTRWSNAIEYSGASFDGLVGETITIESTGTIPSGRAVFVRAAARINYDTPRGSGIRRWNYNEATQVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBX8</accession>
    <name>A0A654EBX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor MprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="17394" checksum="1B385D32A1479D10" modified="2020-04-22" version="1">MKIEDEIKGEGFMSVQHKLRVNLSFTHGWTYERMQQFFAGYDLTAQQYTVLRILRGAFPLSYTTSQILDRMAEKNAGVSRMVDRLQKKELVIKEVSSKDKRLVDVTISYKGHALCERIDEEIKELDNIYNNLSLEEMDQLNDLLDKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC73</accession>
    <name>A0A654EC73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024794848" evidence="3">
        <location>
            <begin position="21"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="571"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="686" mass="76238" checksum="5EAE5D44116C3D42" modified="2020-04-22" version="1">MKKSVAVYLFAYFVTLSTFAQETVVWGSQVVDVSSEYSPLEYSAIQALHKPNVMPSGGDNPNAWRPKSENGEEFIMVSFDKPIRAKQVAIAESENPGAVTRVYAYDNEYNEYTLFELTPRAIPIDSRLLNLFFDDTPYEIYAIKVFIDGEAVPGYNAIDAIGISASNLPISVLINLVPGMAQNKEADKLSTNVNSPYIEHSPIISPDGKHLYFSRRYHPDNVGGVDDVEDIWVSDLDPKTGEWLPAKNIGPPLNTEGPNFISSITMVDGEEVLVLGNRYGKKGRMYTGVSVSRRKGDKFDDPVAVEVTNDYNYSPKVDYFLSASGKAMVIAAERDDSYGGRDLYVSFDQGGTWSEPKNLGDEINTAADDFSPFLGIDEKTLYYSTSGLSGYGGSDIYVTIRLDKTWERWSDPENLGSSVNSKGDDQYFSIPSSGKHIYFSRGTIDDDTDIFRFKADDIFLDKGSPLMETVGHLTTDKPDAYFATIKGRVMEQGTNMLMPGVHMVLERLPDGVDIGQVRSDENGIFEMTVRGGARYGLLAKHPGYISTNENFDLNKLASNDSIVVDIYLSQIKKGASIVLKNIFFDFDQAVLKTSSYPELSRLLEYMQSGEIKKVEVSGHTDSRGDADYNQRLSQRRAQAVTNYLRQNGITADRIVTMGYGEAQPIDTNDTSAGRQKNRRVEFKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECN7</accession>
    <name>A0A654ECN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="159"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="33841" checksum="F0560B6AD173B66A" modified="2020-04-22" version="1">MWLILAFASAFFLGFYDIFKKISLNENAVIPTLFFSTVMASVIMLVLVVVSDMGYLTPDQLMYVPPVSGGDHLRIILKTVIVLSSWIFTFFAMKNLPLTILAPIRSTGPLWTMLGAFVIFSERLNFFQLAGVLVIFVFFYLFSTAGKLEGISFRSNKFIWFLIAGTLLGTCSALYDRYLLRQTDVMAVQAYFTFYQTLLLVPVLLLLWYPGRAKTTTFQWRWSIPFIGIFLLIGDYLYFYSISLPDSLISVISLVRRSNVLIVFLFGAIFYQEKNIRKKGIYLAGILLGLLLLILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED73</accession>
    <name>A0A654ED73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="325" mass="36218" checksum="B2E060AFB87A5A57" modified="2020-04-22" version="1">MKKALVCGAGGFIGGHLVNRLKKEGYWVRGVDLKDNEYGNNNADEFIIGDLRDVKIVSEVVTQDLDEVYQLAADMGGAGFVFTGDNDSDIMHNSALCNLNVLEEVRIKGIKKIFYSSSACMYPEYNQMDPDNPKCSEDSAYPAAPDSEYGWEKLFSERLYLTYGRNHGIDVKIARFHNIFGPLGTWDGGREKAPAALCRKVAETPEGGIIEVWGDGKQTRSFLLVDECVEGIRRLMESDFHGPVNIGSEEMISINDFAKMIIDISGKEITIRNIKGPTGVAGRNSDNKLIREKLEWAPSMSLREGTEITYKWISEQVREKQAANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEE9</accession>
    <name>A0A654EEE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014985">
        <property type="entry name" value="WbqC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08889">
        <property type="entry name" value="WbqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="27570" checksum="3F056EE3099E9AC4" modified="2020-04-22" version="1">MKLAIMQPYFFPYLGYFQLIHSCDSFVFYDDVQYIKGGWVNRNRIQYRGEVRYINAMIEGASANKRINELQVVENIRWKDKLLKNIESCYYRAPQFDQVFPLISEIVNTPFRSLSEFNINGLKKLCKHLSIDKEFIVSSAAWDNDHLKGLDRVLDICKRLNCDFYINASNGRILYKKEDFEREHIRLAFIKMKDLTYNQSNTQFSDNLSILDAMMYNDVTSMGHLLRSYTLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFN9</accession>
    <name>A0A654EFN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="21393" checksum="AA3C85E8A0CF89F2" modified="2020-04-22" version="1">MKLPALFFLIQLFLSIGAPLPAMELEARVIALAGHWEREMALLTQYHGLASFCESADHREGVYGLLDEIHNYHGLLYQELLETTHHHSARTIRRILKHLVKLEEDYSIESFNAFFGERCKAQTELEAMARQYKSGFGMHSYDGKIHVLEIEMHRYLKTLTKRISKVKKHVSQFYARRRVWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFQ9</accession>
    <name>A0A654EFQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032274">
        <property type="entry name" value="DUF4835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16119">
        <property type="entry name" value="DUF4835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024869139" evidence="1">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="34328" checksum="0A08E31D9FC7AB7D" modified="2020-04-22" version="1">MARLLVFILFIGALSTTAQELNCRVVVNAQQIQTTERNIFSDMETSFTQFLNNRKWTDDEFSSEERINCNIILTLDPNESTPSSGRWGASVQILSSRPVYNASYETVVFNFADRDWQFEYVQSQPLQFNENSFTSNITSLLAYYAYTIIGMDYDSFSELGGTRHFQIANQIVSNAQNSNYSGWSQFNSVRNRYWLSENLMGSNFEPLRKAVYEYHLKGLDVFMDDPEAARNSILNGLKLIQTANKSRPRSILTISFLDAKAEELSQIFKEGNPTQKRESYEILSKLDPSKSDTFKKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSU7</accession>
    <name>A0A654DSU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pyk</name>
        <name evidence="14" type="ORF">MARINOS108_10145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="7"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="363"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD10637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="477" mass="52831" checksum="137286B6205B2178" modified="2020-04-22" version="1">MKKSLFKKTKIVATIGPASRNKETLAELIKAGANVFRLNFSHGTHADHQKTIEMVRELNDELGANVALLQDLQGPKIRVGQVENDGVPIAPGQQLIITTKDMLGTSEKVSTVYEGIVNDVKPGDAILIDDGNIELKTIKVSGDEVITEVVHGELLKSRKGINLPNSNVSAPSMTEKDIEDLEFGFQFNLEWVALSFVRKASDIIEIKKRLVAAGVNTKVIAKVEKPEAITNLEEIIRETDGVMVARGDLGVEVPSENVPLLQKRMVRLCNRAGKPVIIATQMMESMIENPRPTRAETNDVANAVFDGADALMLSAESASGKFPVQAVQQMAKTIVAIESDSRTIYSKYEEEDTESTTRHNDLLVRSACRLSDQVGAKAIVGMTKSGYTGYRLSMHRPKANIFLFTNQKHLLRQMNLVWGVTGFFYDKTYGIDETLVEIEKELVKEGYLEKGDFFINTASMPLHWKGHTNMMRVTQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT19</accession>
    <name>A0A654DT19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="9775" checksum="D6D77BC1B233F953" modified="2020-04-22" version="1">MGCVTGKRQYDTQSQAEEALIETRGRFVFREGSGPIDVYQCDDCGYWHFTSKGTVSDLLKKADTKKQISDQQEAQFWERKFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTA9</accession>
    <name>A0A654DTA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box-containing protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="190"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="462"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="515"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="584"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="756"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="954"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1595" mass="183029" checksum="32E318837138A9F1" modified="2020-04-22" version="1">MHDIVKSKGNHPLIKNGILSVFLIDSNGSILEANERAHQLTGFKSLCDTPIQTILRTSSLDISRESEGITFVSTAQGEMVPCEYSFTHEGEPYTETFVGCLITIKMPDLIGQLSEDSLFHKTFHSNVIGMAILDDQHKIIDINESLCQIVGYEKLELIGKTALEIGLVTEENAENREEILRHLAKGNSIRDLERRVLSKTGSYITFLLSIEIFDLNGTPHHLVTANDITKTKTAEKELKGAYEQLAGHLSNSPLGIVEYDQSLTVTQWSSRCEEIFEWSSEEILSNDITAFNLIYEEDLEKTSKVAVDLMSGKVSGNVSINRNYTKSGKIIDCVWYNSTVKNERGEVTSVMSLVQDITENKRVQNDLLESKKELDLFFNNSLSGFFFMMLEEPIEWNDQTDKGTVMEYVFDHQRITNINQAMLDQYGAQKEDFIGLTPRDFFEHDLENSKKIWIDFFDKGKLRVDTDERRMDGSKFWVEGDYTVLYDEAGRIIGHFGVQHDVTARRDARKNIEKSEQKFRSLFEHASDGIFITDTKARIIDVNQSGLRMTGYTAEEVKKLGILDLIEADDLPEMMQDLLSGTHRMVERVAMRKNGEKFNVEISSKLTEDGNIQAIVRDITERKEAEKALREGEQILREVGRIAKIGAWEFEINSAAKGIWSPEFLEIHNLKENIPSDQESWINLYSSDSQKKIQNAIYDAIKTKKPYDLEVQLLDSDKWLRVIGQPVVEGGKVVKLKGATQDITAQKLSEKKIIDEKELSDNIINSLPGVFYLYDQEGKFLRWNRNFESVTGYTGNEIIKMHPIQFFPEDQQELLAEKIGNVFVSGEDNVEADFLLKNGQRVPYYFTGIAIQYNDETCLMGVGIDISEKVNAEKSLQKSHKQLTTAQEIAKLGYWEWNWDTNETYWSDEMYKICGSNKSDGPIPEETFKMMIHPDDRQKVSADRQAMAKDGMGRETEFRFITSNGDVCYIQAVSSISFDKNGKLIRVEGTLQDITESKKRDLKLQQSYERFDLIAKATNDALFEWCPSSNKAWWSDSHYLLFGFDRANGLPSFDEWLEKIHPEDQGKILEKLEQIQNRKATGWTDEIRYEIASNKYGTLLIRCFAFMAAPDEQLKILGSFLDLTESKKAEEAIRKSNERYELIAKATNDAVWDWDIVNNTLIGNDQLYSFYGKNRTTDFLSDESFFSRVHPDDIDKLKKSMSDALRHGKTSIIEEYRFKDPDGSYRSILDRSYVMFDDNGIPVRMLGAMQDVTDQKKAEKELQELSNRLILATTSAHMGIFDWDIPDNKMVWNEYMFGMYEVGFDDFDHKYEDWTKCIHPRDVASFETKVKEAMKTGHFNEKFRVVWTNNDIRHIEAHAIVTKNEDGEPLSMIGVCRDITERVTAEQKIAKAIINTQEEERYELGRELHDNIIQLLVASVMNLNHLQSIPGYDHQSIAKAHSYTDSAINDIRKLSHRLAPSNMEETPLEDAMHKLLQSINTNDQYEINFDTQICPEVELSAVIKLNIYRILQEQLNNILKHSQATKLDFWFQVNEFKLQMILQDDGKGFNPKHDGEGIGLNNIRRRVEMFNGNMEIHTAPEEGCQIIIEIPMTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTI9</accession>
    <name>A0A654DTI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="32"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="323"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="548" mass="61404" checksum="C0943A0C6D4195C7" modified="2020-04-22" version="1">MNYGLRKFKNMKAFKIIIIALILCVACSEETLEVKPVNQYLSENFYSTNEQVYAALIAAYDPIGWSMAFGQWVSPVMFGEIRSDNANAGGDPSDNDQPAWQELDDFRETNTNTLLQPIYRKHYIGVFRANLVILQTELATPEVERYKAEAKFLRAYYHFELFRHFGPLPVVTELLTPDDINLERSTMTEMMTAITDDLKAAIDVLPTTLSDVEVGRASRGTAQALLGKVYLYWADLDGDDPAKFDLAAQYLQEVVNSGQYALVDDFSTLFDYGTKNPIESVLEIQHTNLWPGDWGWFEGIEANGILQLCGIRGLCSGHPEYAAGWGFMLPTQDLNDHFLPDDQYRRDVAIVSIPELTQEVADAGAADCGVVVDITQVNPQDHTGFWQQKFSNYKAYNGNNVNGGDPNLTKDANTYAIRYADVLLMLAEAMHRGSGSDGNALTYIDMVRERAAGPGDNTGSFKTGQTIMTEQNWTLLDLIWYERRAELAGEGDRWYDLVRSGRATSDLFSGDPIRSGNLDPQKVWIPVALEETSVAHQISTYPENELFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTN5</accession>
    <name>A0A654DTN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="13858" checksum="FF14F17D1EFA7C7F" modified="2020-04-22" version="1">MIKQIRCVVIDDDFASRAILKGLIRQDERLILVEECSGSADGAVSITKHKPDLVFLDLMMPGLDGYEVLEVLDYMPKIIVVTTERNYKSEIFSDRISEYLYKPVESLEMFTKAVDQAMKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTY3</accession>
    <name>A0A654DTY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024930693" evidence="3">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="221"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="375" mass="42218" checksum="6804F46405977643" modified="2020-04-22" version="1">MKITYLLLLLVMVIGAEAVAQDHSKKVDPLPIGSLAPDFTLPATDGNTYSLADFKKKYLAIVFTCNHCPTAQAYEKKLISIVDEYSKKGVDFVAISPNDPNAVSLSELGYSDLSDDLEDMKLRVKEMNYNFTYLYDGASQQTSLKYGPAATPHVFVFDQDRKLVYSGRIDDTENPYITPRTTDLINTLDELLAGKQPSTPTTKTFGCSIKWAWKNDWLAKEREGWSKEEVTIQPIAVDEVADLVKNTSEKLRLINIWATWCGPCVQEFPDFVDINRMYRGRDFEFVSISGDKLSKKDKALEFLTKKEASNTNYIYSGDNMYDLIEAVDPNWQGALPYTLLVAPGGKIIYQVDGTIDPYELKKAIVGYLGRFYADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTY5</accession>
    <name>A0A654DTY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="46" mass="5429" checksum="7A25F81B3C11F756" modified="2020-04-22" version="1">MKDKDKDQKLINDLIKKRKEENDAFAKLLNEISNKQQPLKSTKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUC4</accession>
    <name>A0A654DUC4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">can</name>
        <name evidence="6" type="ORF">MARINOS108_10323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="24210" checksum="C4DB9782AF0DBB8E" modified="2020-04-22" version="1">MSELYKELLAGNQNWVRNTLKLNPNFFDSLAEAQNPQFLWIGCSDSRVPATEITNTLPGSIFVHRNIANVVVHTDSNLLSVVNYAVEVLKVKHIIVCGHYGCGGVKAAMSNEDFGYLNNWLLHIKDVYRLHQKELDAIEDTHKRFDRFVEVNVQEQVHDLSKVSFIQEKWKTGEFPYIHGWVYSLKDGLLRDLNVTINSQETLDKVFRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUE7</accession>
    <name>A0A654DUE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024969713" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="ASH" evidence="3">
        <location>
            <begin position="248"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1144" mass="126053" checksum="6C19434BC97CA026" modified="2020-04-22" version="1">MKSLLTIQSLLLTIIGFSQSFRADLTNVTKEVFSGDSVTQIIKLTNQSASSISLDISIPSASKITFTKANGADWTLEENQDVITDNVKITRQNSRGIFNAALENSFDSSSPVDTEWAFGKTKDLNKEDYSSWVEAVNYEPSTMLNRDMSLHLISEDQYYDVFWTSWTCCGNGGGFSYDRTRAVYWLEVNEATIDIPLDGSVQIIVKLSALNLTAGTYLDSLTITEAADDADSISIDVSFTVDDAAGIFSYADSIVFGTQFIDASHSQTIKIKNVGSLDLLITEILINNDAYTISPNSSGIDPGQSQLFEVTFSPTSAMDYSAEISFLSNDPTNSSISIPVTGLGVEPPIINVSPVSLQSSLNTGDNEDQSFIIKNTGNSTLYYDTELYERSSSGPLTFELLKNDPDEVETGFDVKNVYTGFTNNEIFIKMENYIPFEDGEEEIIKETVIAIDADQNTETGLDVERVFDWGLGVEYVIYFDSESFILAKYNQTTDEFDEIGLVDYQFDPELGQTTFTLERRHLTEKFNFSILISEGYVDQIPDTGAGNIEFSFNPSWLTLDKLDGSVETGGEQQINVSIDAENLFEGKYEAVLTLNNNDPITNEVLVEVSLDVIGFAKFVGPEILDFGETFVNIKDSLYLVVQNPGTATLTLDQFSSESEELSFSSNSLTIKPFESNFITVYLKAANIGDFSSNFTFTTNDAQVLSASIPVTASMVAPPIAELSTNTIISSVYKGNSTTEQISILNSGGSSLQYEISRPLRYALSLDQEYYSVDFENSYLIGDLDAITVSMWIYLAKRIDCDNGNNWRLLLSKSLSFATGSGFDIILEDNASFSWSLGTENGILRHGSDYELPVGEWTFVSFTYDGSIAKVFANGVEVSGESDNPSAGGKILSNFSQIALSAGAASCQENAGFFPGLIAELRLWDIARTSNELVDDMNKRLVGDEKGLIGYWLFEEGEGDISADLTGNGYTANLYQETVWTENSPYNWFSITPTAGTIEFSNESLVSFNLDASGLQIGDYNTEIVVNTNDPYNQEIPVKINFSVDEPLGLPYTDQLQIVAYPNPFAEEMTIEYELKNESSVNISIFDESGRHVSTLVSEFQTAGQHRVTWHNSQAIGSLSHGMYHVLIQMGDGKTQSKRIVYSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL6</accession>
    <name>A0A654DUL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxypyruvate reductase</fullName>
            <ecNumber evidence="5">1.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpr</name>
        <name evidence="5" type="ORF">MARINOS108_10775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="109"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="316" mass="34890" checksum="091E6457CA35739E" modified="2020-04-22" version="1">MRFKIVVLDGIYANPGDLIWDGLKPHGDFTIYERTAPEQVMDRALEADILIVNKVELRKALLYKLPKLKMIVISATGMNNVDLEAAKEHGVLVKNVVGYGAPSVAQHTFALILELTNRVSVHHHSVQNGEWDSGKGFSYTVSPVTGLSGKTLGIYGFGSIGREVASIGRAFGMNILVVSGHTLPAYYPDYEFVSLPELFERSDIISLHAPLRDDNERVVNRALLSKMKPDARLINTARGPLIHEEDLKNWLMAHPMAGAALDVLEMEPPGAQHPLFGLTNCIITPHMAWTAKSARKKLIDEVVLHVTKFVSQQNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT5</accession>
    <name>A0A654DUT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="384" mass="42463" checksum="1425D2CA3186C1AF" modified="2020-04-22" version="1">MSLEMMLVKCALFLIALTVSFASSGQVTFLIESLPDNHPEGDSIYIAGSFNGWNPADGDFLLQKGDQPYITLDGDAPIAFKFTRGSWATVEGNASGEKIENRSYSFTGLPDTVIVSIASWEDLSGTANPVSSTRASNVTTIDQFEIPQLNRSRRIWIYLPPDYTESDDRYPVIYMHDGQNVFDAASSFSGEWGVDEALNELYEQEGFTAMVVAVDNGGDKRIDEYAPWSNADYGGGEGVAYVDFLIKTLKPLIDDHYRTRPEAAHTAIVGSSLGGLISYYAGMKYPEVFGRVGAPSPAFWFNPEIFDFTDTVALHPKTRLYLSAGGAEEASTATNMTRIADQLVSRDFPKDQIHTAVHPDMQHNESYWQSIVAEMVRWLMDNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT8</accession>
    <name>A0A654DUT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Haem_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="1">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="18942" checksum="7AD042A41F950CDF" modified="2020-04-22" version="1">MWFSKGDHFNEMRKWHRLALGVLFIVLLGIQFFPIQRNETELVSNADFIKSYQPPIAIGNMIQSSCYDCHSNQSRYPWYSNVQPIGWLLQNHISAGKSELNLSAFGNLSNRMKRMKIKSIISQIADDKMPLPAYVLMHPDAKLDSLKKAQLTNYFDSLVNNFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ9</accession>
    <name>A0A654DUZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6605" checksum="5C780BDA63424845" modified="2020-04-22" version="1">MQHVDFLQVFYWLRMKICYLTTVKKVQLSNEKKYPNITSVRLLRLSGKGKYTTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV21</accession>
    <name>A0A654DV21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024800602" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="413"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="532"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="4">
        <location>
            <begin position="654"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1365" mass="145105" checksum="61E823EB8E9A949F" modified="2020-04-22" version="1">MIPKPYKILLTIFWLGAQVGFAQTGPGGVGNTTTNRLWLKADGNVYSDAGVTVATDGVAVRQWNDHSGNNNNASQATLGNRPVYATNVINGQPALRFTGNTYIDPGALGIAGTGGFSYVIVFKDTSYTAGGMSDGAGDYLIDRTPATNELAGLKIANTNKYGFQKRTNAGGGLGGPVSATAVNTTNFHVIDYQRQRGTSYQLYLDGSLDASVADADGDLTPPVPRIGRHFNTANNGVKGYISELIIYNTHLNTAQLNIINTYLAAKYSLTIANDKYAYDSNHGHEVAGIGRENASNTHTAAMSGGILRISGASALGDLDYLLFGHDNTDVTSTWTSTETPSDKSGIQRLSREWRLDETGDVGTVDVTVDVATLPSLPVDHTLYALMVDSDGDFSSGASVYELTFSSGTEYTVNALTISDGDHVAIAAIEPLVQHTLSTSSDFEPNDAVVEVELNFITATDRTVDYDTSDGSAAAGSDYTSVTGGTATILSGTSSGSYTISITNDVTVEDSEDFDITLSNPSSGITLGSIVSHTYTIFDDDNSRKIYLDASSSSGDESVTGVSVSISINNIDGVNPTSVDYSVTGGTATGGGTDFTLAAGTVTIAAGGSSGSFNITINDDALYENNETIIITLSNPVNCNLDGVAPLGGTGFIVYTYTINDNDSPPVIQFTTATSSGSEAVSSVNFQIDLDAISGLNSTVSYAVSGTATGSGTDYTLSSGTFTIPAGSASGNITATVVDDAVLELRETIVITISSPVNASLGTNTVHTYTILDDEFFGYTGPGGVGDASTNKLWLKADTGVFADAGSTMATDGNGVQQWQDLSGNANHANQATPANQPIYRTNIVNTQPAMNFTGDTYIDAGSPGIAGDGGFTYFVVVEATSYASGSTSDGSGDYIIDRTVDTNELASLKVANTNKYGFQKRDNSGGGLGGPVTTTNINTSAFQMVDYMRNRGSNYQVYLNSTLEGTLSDSDGDLTPAATRIGRHQSIASAGLKGYISELAIYNFGLNTAQRIIVDNYLSAKYGITISNDRYAYDTPGTYEHYVAGIGRETISSFHQDAQGPAIVRIYSPSSLDDGDYLLWGHDNADPMYGPRFIAWTDPPAGIDNAMHRTWRVDETGEVGTVSVSFDLTGYEVESGSHLRLLVDSDDGDFENATLYPVSSYTDSIATFDNIDFSAGQWFTIGSTDEKTILPIELLSFEGQFITNRVDLKWVTVSEHDNDYFTLERKGRNAEWLILDSIQGAGDSDQLLTYVWSDWQPIDFAYYRLKQTDYDGKFTYSQSIVVMAEYLGLPAFNIYPVPAVSTITLSGNINRLDGFSVFDPAGRNVTYLIEVLNHAPARIELDVSTLPNGIYFIRSSGAVRRFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV59</accession>
    <name>A0A654DV59_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21418" checksum="063BABD8A770BF63" modified="2020-04-22" version="1">MGLEASTVNLHFEIIERCRHGDEAAQYELYRLYSKAMFNTAFRICGAREEAEDVLQESFLSAFKHIASYRAEASFGAWLKRIVVNKALSALKKNAREALMMEEVVDEHQYEVQNNDTPATIDVDRVRMAVMELPTGFRSVLSLYLFEGYDHKEISEILGISESTSKTQYKRAKDKLRSLLEKEVSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV84</accession>
    <name>A0A654DV84_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="902"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="926"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1201" mass="136894" checksum="B5ED59EC05647E38" modified="2020-04-22" version="1">MRLKFSFFLFLLILLAVLFYGITSNRQPETIAQVISTNLQTVLRAQQQDIDQFENELAVYTNPFSIKDNARFSKRVFVNGGLVYWTDNQFYPEYGALKKSDTLYTIKDDFGVRIVKGRQVVTDRDLIEIFSMVTLYESPPVKNQYLSDRLNSEIFEAYELRITDSGPHTFSFNGIPLFTAVISEQGHPNGEWMGLVALILAGLLCVWFVISALGRSSYSKLQRSGLLIMIIVGWRLLLFWYTQTAVGDWDLFNPVFFAADLINPTLGDLLVNGFVLFIISAIVYSAVVSDLSDWVSKLSRPGAIGIGVLLSLMIVMVAWLVYGSTWLLLEHSQVELDISSSIVFNELRISAYAFLILIGLSVMLIFSICQLTLFVLPVNKVLKYILMVSALPLTIVLPGPGLGYASAFVLLSCLVDFWKFSKAINRLRYQTFIFLVMVFATTSIVSSLAVYKHHEKDDLVAKEKFANRLLIRNDIIGEYYLSEIIQEISQDRYVRTRLMSKILARQNIREKIKRQFLASYFKKYDIDVYLFDAAGESLQPDVSTKSYKAWQQEYAIPEYYTDYEGIYFMEDREENVRNKYLCFLEISAYGRQVGYILLDLTLKKYIPSSVFPELLLESKYYLGSKVEFDYAVYKNGEMLYKQGRYSFENKLSSAEFQDEELYDNGLEKGGYHYFGLKTVDNRTVIIVSPTYQTQAILANSSFMFLLLVFFTGFLFLGARIFVSGAQFNLSTKIQVYLGLSFLLPMLVVSVALINTLNSSYREEIDRNFQKRSYNIAENILDQSEMFFSNQINIDEYANEIVEAATLAQSDLNIYDINGRLVITSQPEIFRLGLLSRLLDTKAYYQIKNKREQNIILDETIGKLDFKTSYTALRSYKDGRLMAFLSMPYFDSKNHLRQQQVEVFNSLVVIFSIIFLISLLGGNVIVGQLVRPLKKIGERIRKISLEETNQPIHYEAQDEIGSLVKEYNIMLVKLEESKEALAAIQKESAWNEIARQVAHEIKNPLTPMRLKIQQMMRSFETESKEYKTCEALISQVDSLSSIADSFSEFAKMPAPNNEPVEVIGLLNKTIDLYQSNEVALKKDYEVKSVMVYLDPKIFSRVITNILLNAIQSKETPETHKIKVGVRVSGDKMILSVADSGMGISDEQKEKVFTPYFSTKSKGSGIGLAVAKKGIENAGGNIWFESEQGKGTTFYISLPVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVH9</accession>
    <name>A0A654DVH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024993625" evidence="1">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="235"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="350" mass="40410" checksum="6C89E81CBAD04F47" modified="2020-04-22" version="1">MLKRLVTFLLLAGSYLTHAQEHKKVMAVQGDGIYSLLRNSGLEPKKYLAPFIELNKENLSSENGLFIGRIYLLPKPEEKVEKADEEVVMPDSVDMQTVKATKVLEKRYYGIFGADYAMVSIESRQLEGAVFYLISGHGGPDPGAVEHYGGQLLAEDEYAYDVTLRLARKLIANGALVYLITRDPNDGIRDARLLEVDHDEETYPSKRIPRNHSLRLKQRVEVVNELYERHAAKPYQRIIETHVDSRSKSENIDVFFYYHELSKDGQRLAQNLQQTFKQKYARYQPNRKYSGTIEPRNSLYIIKYSKAPTVYVEIGNLKNTRDQRRILDWENRDAIAMWITDGVIADFKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK8</accession>
    <name>A0A654DVK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="5123" checksum="923F4C1B0D95716D" modified="2020-04-22" version="1">MVNDFTKFSIYTHENYDLMKKDKVDFSESRASFSNQMPMYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR5</accession>
    <name>A0A654DVR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19040" checksum="FCF9EA3DC4D8AF0D" modified="2020-04-22" version="1">MPDGVFITKVLSGECFRKDHIIRLTQNALRIPSSQWVGEKSKEISICEEDMFFKELFVFVFDQTGFQAGTAGMNFPFKVSFQRSRIGSGGDANFKWTSVHLSGSEHAVYFMVVLMKSVVFQLTGDIEIQEKHAQKANGESRNINDSIHSLFAQIADGQKWVKDEHGMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVV9</accession>
    <name>A0A654DVV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="205" mass="24025" checksum="F00003BAFEAB5DD6" modified="2020-04-22" version="1">MSLIRYVSFILFIFNVLFAIDAYQTYHLPVSLTNLAREPVVRIFNTKLYYDESARDRSKEELSTTIRQIYLLRDKLHNKDSREVIDMALPSLVQLHYDLKSDTGNIEMNEHFVKMLLALSYVQVRYAQTACAQRKTAEVHTSLRTAMGIIRRALFLSEGTKRDFEINIYAEMFDLLKTKVSHEEMEKRLGGILDEIRDLEVSFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW64</accession>
    <name>A0A654DW64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="64" mass="7336" checksum="FDAC968C6F5FA88C" modified="2020-04-22" version="1">MKNRIKVLRAERDITQAQLADELGVSRQTINAIEKGKFDPSLPLAFKLAGLFRLTIEEVFQYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWB0</accession>
    <name>A0A654DWB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="644"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="927"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1090" mass="124935" checksum="904BBADB87D1E9E4" modified="2020-04-22" version="1">MDTSETISGGSLFPYSITLNEAFFAIEANNATFSVSVIQQQSQTILFCECAENTNQMCLHQARALSALTRQEDLQLFFDNQLRHARLKRVAYDYGLENEPDLDEHFRLELYQNRLVINPVNPALTAVTHEHLAELRNSILSPEPPTAPVANSEAETEFIVLRQHKYYKGLQAELCAAPHTQQGKIKAPIRSIDTQAAIWHTSSPGDIKFLMGVGQLKNRTEERLGTRDITALRAVIQNPANYPFYYHQASASESLSPKSLLPIKVRRLQEDITLTVSESKGVYEIYASVSINGVTHQVADLSLRLQCFLVIAEVWYFIDKLPVLSIVQLLKQKSGRMLIYASAFREFKAQFLDKVADKIHIEYTFIAKASPRQLAASEYVSDTEKIIYLSDFGSHVMIMPVMRYNDVEIPVRTKRQVFGKDENGGEFLVDRDTQSEIELTALLIRQHPDFREQLENELDHFYLHKRQFLNEDWFLPAFEDWGHAGIRVLGFNELEGNKVNPHKARIDIKVLSGLNWFNATISARFGRKKASVKKIQVAVKNKSKYVQLDDGTMGILPQEWIEKFAAYFTAGDLNEEDMISIPKINFSDIEELFDEEMLDETTKRDIRLLKQKVEDFTSIQPVPVPKTLQGTLRTYQQEGLNWLNFLDEYNFGGCLADDMGLGKSIQIIAFALLQKEKTPNSTNLLVVPTTLIFNWQAEISRFAPSLSVYTLQGADRIKGTDGLEKFDIILISYNTLLTDINYLRYFEFNYIFLDESQQIKNPESQRYKAARLLQSRNKVVITGTPIENNTFDLYSQFSFACPGLFGNKRHFKELYSVPIDRFKDSRRAKELQQKIKPFLLRRTKQQVAKELPKKTEMILYCPMETEQRETYNAYEKEFRDYISVTEAEELERNPMHALKGLTKLRQICNSTKLLKSDEILGKKTSSKIDTLMEQIENNAPHHKMLVFSQFVSMLELIREELDARGIRYALLTGNTRNREAVVESFQQNEDIRVFLISLKAGGTGLNLVEASYVYLVDPWWNPAVENQAIDRVHRIGQENNVTAIRLICPDTIEQKILQLQTTKKQLSGELITEDSASAKLLSKAELLKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWC6</accession>
    <name>A0A654DWC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="105" mass="11757" checksum="15EF1071B074C44E" modified="2020-04-22" version="1">MAVDLITDNDFENVITSNEKVVVKYFADWCGNCRLFSPKFKRLSNDERFEGVTFLDVNAEKSPEARRAGGVTNLPYFAVFKNGELLEGFAGSKEDAVVELISKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM0</accession>
    <name>A0A654DWM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coenzyme A pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="23370" checksum="08E4E9409719D1DC" modified="2020-04-22" version="1">MQALINKLRIKLNQPLPGAQAHNLMSPKLSTGNRVNFKFDRAPRKGAVLILLYEKEGEIWFPMIQRPLYDGVHSGQMALPGGRYEETDGDLKVTAMRETQEEIGVEPGQVGVIGHLSEFMVSASNHLIVPYVGFSKEIPRFIPDEVEVDEIIEAPLSQLLDKSRLKEKEIVTAHGYRLHSPYFDIQDKVVWGATAMMLSEFAAIIEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWM4</accession>
    <name>A0A654DWM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_10777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid alpha-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="PTHR12863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="10">
        <location>
            <begin position="60"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="23169" checksum="41D4B379883F99B5" modified="2020-04-22" version="1">MEIHNKGTKRLFENPILERLTRTHIALPIGIFILYGMGLLYWSIATVQLDPLVTTGLFFGGLLFFTLLEYSIHRFLFHMSTHTSARKNFQYKFHGVHHDYPKDKDRLAMPPIVSVTISTILLFLFKLVIGDQVFAFLPGFLFGYAGYLFIHYLVHAYRPPKNFLKIFWVHHGIHHYRQGHKAFGVTSPLWDFVFRTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ2</accession>
    <name>A0A654DWQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025023535" evidence="3">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="416" mass="48065" checksum="BFA0B2993477A9BE" modified="2020-04-22" version="1">MRVTIILLFVFSAFTAFSEGLSEAYENVMSVYSQGDHSVTKEIAVDFLSIAKEQNDTYYMTKTYYLLGYLCTHTDDFGNAIIYYLEGARHAEISERDDLKPSLIAIYKNLALILGDYGHYSLSHKFINEGLRVASELKDEQQIIILLNNRIHELLSEKRLNEGLKQIDSLLANFHVSEKRFLVMKNKLGAAYGELGNHKAALENYKYVIDRGPEVSPETYALCMENTGGIYLEQKEYSKALEYLLATYDFDSDKQYNQKALRTLGKIGQTYFELSDYGQALNYYQKAIELIEQGNQTPTSYEIFREVSKVYSILGEYETALEYGRQYSEHLEQFIAQQKEIEELDKKYNIQLLTDRYFDLLAANTEKRETERMAKFGIAGSSVFFLGLLLIVLYRNHRVKREIENQLKSIELLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWT3</accession>
    <name>A0A654DWT3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="292" mass="32346" checksum="6D9F529694F6916F" modified="2020-04-22" version="1">MKKHLFVINPVSGSANTHELLHDIDRHFSTSHTEFKILQTTGSNDAAAIQHALNTYCPDVVGVAGGDGSINMVAPLLISTGIPLGIIPSGSANGLAGEFGISMDNALQNILSERTSHLDVTLINDRHYMLHMADLGLNASLVRRYEEENRSGFMGYAISAIQELPMLQRHFRVTITSGNSKTAFETNFLVIANTRMYGTGYEVNPVGKFDDQQVELCMMKPLSAELMINNLFLQNQPDRDSELFDIYSYQEVQIQSSTPIDFQSDGEYIGELTDLHIRVLPDQLRIVVPDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX66</accession>
    <name>A0A654DX66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="14898" checksum="1524F1DD1DFB4FC3" modified="2020-04-22" version="1">MSKQSESWKQVNKRNTANLAVWTLAWTLTMAVVSLGPKYIWENDASISLIAILINTAIGVGMILANKRHLNGLDELNRKVQLESLALALGVAVVGGLSYSMLDVANVISYDAEISHLVILIGLTYLVATVVGLTRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA4</accession>
    <name>A0A654DXA4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoglucanase Acf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041342">
        <property type="entry name" value="DUF5010_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="PTHR31983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18099">
        <property type="entry name" value="DUF5010_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="2">
        <location>
            <begin position="885"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1564" mass="165851" checksum="3C6648C236C47D10" modified="2020-04-22" version="1">MNNPTTPWKSILLTLILIFTFFFNPIAQTIPVGSGSYITVFPGTDAAGRNTFPSGSPQLSGAAGTKPVPTNDWYSNMIKVDHGGQAFNYPLSYKSLTSGLVINYTVPPAAGPTEYRQPMGDVNGIVMGVDGLSASQSTASDHSDWAVTMSWAGSGKTFNATMGIGMPFTYFTKGGSDVAKVSVNHNPAGATVSGNKIIITNNYNGANFVIFGPAGTVWSGSGGQYTSSLNGKNYWSIAMLPPGADVNSAITALEPHAFVFPGNTLSDYSYNEATGTVTTTFTITPDVKEGGNNTFVQGLLPHQWSRLASGSAQPTGMSYPTVRGELKLLHGNTFSVANKFAGILPTLPDLGKYSSGFDPGALYQKIEAIKNDGLAEWTDSYNEGQAMNRLIQVAHLADQIGHTEARDQLVNTVKSRLEDWFKAEGGEVAFLFYYNDTWKTMIGYPAGHRQDQNLNDHHFHWGYFIHAAAAIEQYQPGWAAQWGGMVDLLIRDASNPSRTDAMFPFMRNFSPFAGHCWANGFATEPFGNDQESTSESMQFNSSLIHWGSVTGNDAIRDLGIYLYTTEQSAIEEYWFDQNDRTFQPEYQHEMVARIWGGGYDNGTWWTQDIAASYGIQLYPIHGGALYMGHNTAYVQEVWNGMTSKTDVLNNVSNDNLWYDTYWSFLSFSDPELAISLYDAYPDRNIKFGISDAQTYHWLHAMNAMGQVMEEVTADYPISAVFNKNGVKTYVAHNYGSSSITVHFSDGFSLNVPGGTMVTNRDITPTATISASASEIPANGSVTLSASTSGSGITKVEFYRGNLLIGTDTSAPYSATDNNVPASLVNYYAKVYVGSSLDVSNIVRVQVGSQLPYTGTPAAIPGTVEAGYYDSFEGGSGQGIAYSDATPWNEGDFRQSEAVDAGSTASEGFTVGWIDAGEWLEYTVNVAQAGNYNVQIRYTSGSASGGGPFWFEREDGTKISEDITVAMNDASWTTYTNKDITGVALGAGTQVIRVRAGNGGFNLGRMTFEYDGTPTPVLTTIVVSPANASIAQNDTQQFTAQGYDQNGDPIAMTPVWSTNGGSINGSGLYTGSAVGNFTVTASASGVSGSASVSVSNQAPVLTSITVSPSSASISQNATQQFTAQGFDQNGNTMSISPTWTANGGSINGSGLYTGSSVGSFTVTASAQGVSGTASITVTGGGGTSCSFQASTGDYTAEVSSDSPNPTITFVPSVSGVGDNVTILYYGTSPTGGYPGYIVSPNAPYQINAAAGQTIYFYYTYSLPQGGENNTSASRHSFEVGNCGGGGTPTPVLTTITVSPASVTLELNDTQQFSAQGFDQNGNPMSMSPTWSATGGSINGSGLYTANSAGSFTVTASSQGVSGNTAVTVNASSGGGCTFVASTGDYTAEVSSDASNPTITFVPSVSGVGNNVTILYYSTSPTGNYPGYMVSPNTPYQINAAAGQTIYFYYTYSLPQGGENNTSATRHNFVVGNCSSGARWAPESTASQAISDMMIYPNPVNDMVMISGLSEAGELELVDVSGRVCQKWLINTTDGRQQLDLKHLASGTYLLRIISSQPKTLRLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI0</accession>
    <name>A0A654DXI0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">msrB</name>
        <name evidence="5" type="ORF">MARINOS108_11076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="134" mass="15021" checksum="2CCB3914FE45663A" modified="2020-04-22" version="1">MSKPEKIDLTDADWSEKLTPEQYHVLREKGTERAFTGQLLNNKADGIYECAACGNPLFKSDTKFDSGSGWPSFFEPYSKDSVVLKMDKSFGMVRTEVECARCGGHLGHVFHDGPQPTGERYCMNSISLNFKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXJ2</accession>
    <name>A0A654DXJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_10281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="137"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD10866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="438" mass="50133" checksum="CD20B9ACCA8288BE" modified="2020-04-22" version="1">MKRVAFYTLGCKLNFSETSTISRMFEDRGFKKVDFTDQPDIFIINTCSVTENADKKCKKIVKEAKKISPKSFVTIIGCYAQLKPKEISEIKGVDAVLGAAEKFRLFEYLDEFIATNEPQVYASEIQEAKRYNASYSYGDRTRTFLKVQDGCNYGCAFCTIPLARGKSRSASIAEIVEQAKEIAASEVKEVVLTGVNIGDFGIQDGKRKEKFIDLIKALDEVEGIERFRISSIEPNLLSTEVITFVSQSKRFVPHFHVPLQSGSDKILQRMNRRYLSDLYKERVHTIKSLMPHCGIGVDVITGFPGETEEDFLETYQFLNELDVSYLHVFTYSERANTQALEMDGVVSLKDRQKRSKMLRALSEKKKRYFYEQHVDQMQTVLFEDDVEDGHMHGFTENYIRIKAKYDPVLINEMKVVKMARVDASGLMEVEEVEEILAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXL8</accession>
    <name>A0A654DXL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="5001" checksum="0E9943C4D22E7458" modified="2020-04-22" version="1">MHVISLFQVLAQIYFHSSGGYTENELGVKLVPISHKKYDSGHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY36</accession>
    <name>A0A654DY36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="34635" checksum="3FDC830600D95810" modified="2020-04-22" version="1">MVNGVFWRDLTTSIPFLKMTFSEIDKLKETNYTLIAQPELNYWFAISSKKLIDHFIKSFGDDFNLILYSSKEKDTDYYVLPFKVIKGLFKEEFYSNDKKTTYTGKRWVGTIKDHLLKVTNNPTTIDIKEYFANPYFFQSKGPDESSNDYEIENKLQEINVRIKQSKFRQRVLANFNNSCCISNIKEQSLLIASHIIPWADKKETRLDPTNGLSLSVLYDKLFDKGFFTISDQLEIVTISDHTNLSKPLIDILNEINGKRISIPIREIKKDFLEYHRTKIFMERDKRTISIKSKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY39</accession>
    <name>A0A654DY39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4145 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4145" evidence="1">
        <location>
            <begin position="134"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="30165" checksum="F20CD5D66ABECAEB" modified="2020-04-22" version="1">MEIKTWLKDSFSKNKIPEWTCPSCNNGLLELEPTQFHFEETKLSLSWHSHDDWEPEFIRYRFHGTLKCKNCMDFIAFLGNGSLDHVHYYNNYQDEYVEDYNEVFYPLYFNPPLNIFQINDKCPEDIKNEIIDSFKLFWNDLPSCANKIRTSLEMLMNQQKVKKTYIQRGTRKNLSLHKRIEEFKNTKPEIADFLLAIKWIGNSGSHVGKLEKVDILDAYELLEHSLNKLFDDKEAELKKKTIEINKRRGIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB8</accession>
    <name>A0A654DYB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="27028" checksum="D49C070E75B64846" modified="2020-04-22" version="1">MKNKFDLTGKTAIVTGGGSGIGRAIATTLAEQGATSLILDLSLEGAQSVAKEIEANGGKAEAHPCDVSDHENVKGAFSKALGNRSLDILVNNAGIAHVGNIFNTTPEDLDRIYQVNIKGVFNTLQAGVESMKAKGGAIVNISSIAAHVGLSDRLAYSTSKGAVHAMTLSVAKDCLGHGIRCNSISPGRVHTPFVDGFLAKAYPGNEKEMFETLSKTQPIGRMGKPDEIGDLVLYLCADESSFITGSDFSIDGGFLTLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK1</accession>
    <name>A0A654DYK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025023052" evidence="2">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="337" mass="36814" checksum="440D0B887C56AEAE" modified="2020-04-22" version="1">MKGSLLTFALVCLSNLGFAQWNGNTFSGGLVNFKSPSSGGSFLMNFHSNVNYGSDRAFILVQDESSDSPGSGSEDLRMTIGVYNDFRHSISHSDELWFQGGGRLVWNVGTWDSQLSSLIGSSTSGTTGGFEWRINNSVKLKLDHSGYLTLGKNGTTSRLLFSAQTNDPAEIRHIESNNSAQFWINPSDDFDVGSTADYFIVGDPDINVKRFYVRGDGLTHVSSALTVGTTALPAGYELAIAGKAIMEEVKVEAAPWPDYVFSEGYELPELGATADFIKANKHLPGIPSATEVAEQGILLGEMNAKLLEKIEELTLYLIEQNERVEKLEKEIETMKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR8</accession>
    <name>A0A654DYR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="15953" checksum="CE18FB9D660D3753" modified="2020-04-22" version="1">MSYPLSFSKSILVVIFISDKIRQGQFEFLSTQMIAEVLDIPKPTLVKIFQGLSMAGIIETREGKLGGIRLVRQPSEITILDILNATEKGKSLFQTTFHIMAEGKRPDNAQKVVRSLLMDAEDQMKQVLASRNIEEILIEMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV6</accession>
    <name>A0A654DYV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008620">
        <property type="entry name" value="FixH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05751">
        <property type="entry name" value="FixH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024912124" evidence="1">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="16700" checksum="43326FE4377A1B1C" modified="2020-04-22" version="1">MKWNWGKSIVLAFVLFCGFISSIVVAAFQQDFDLVSDTYYQDELVYQERIQEHINLAQSGAKVSITQEGRSVVFSFPQEFSGAKGEIHFYHPSRSIFDRSFSISLNEKRQQTIFGEELTKGRYKVKLTWTSGGVGYFQEEGIFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ16</accession>
    <name>A0A654DZ16_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="2">
        <location>
            <begin position="152"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="29625" checksum="79CD1EB6EF046BE7" modified="2020-04-22" version="1">MRIIQHLIFWSTVSLFLVITFGQANGDFIEAFYFVTFLLPVALATSYFFNYFLVPSYLLTRRYVLFGLYFAYTLIFSIYLEMIVLTIALIVLANYTYANLNPYSTNLFLLTSTLYFIVFLNAFILLIRRYQRNEHLLAKMEHTKKKNEREQIIVRVDRKNRALALDEILYIESLADYVKIHTTGEVVITKEKISELHDQLPERFIRTHRSFLVNQLQISEFGKEELLIGEVKIPISRTYRKAVSDRLRVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ32</accession>
    <name>A0A654DZ32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein containing xylose isomerase-like TIM barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="315" mass="35486" checksum="2A8897777A02B651" modified="2020-04-22" version="1">MRISRRKFLQKSGTVALMAPFLPSPVGGFHLNGSGDPLKVHIFSKHLQFLDFKEAGQIASELGFDGIDLTVRPKGHVLPENVKSDLPAAIRDIKQSGSTCEMITTAITDVNNEYDLDIIKTAANEGIGFYRTNWFEYHADKSLQESIQVYQQKIKALGEQGRQYDIIGCYQNHAGTSIGSSFWEIEQLLATVDPVYFGTQYDIRHATVEGGLSWTNGLRLLRERIKTIVLKDFQWAKVNGQWEAVNVPIGEGMVNFKDYFKLLKTYGLNPPVSLHLEYPLGGAEKGHYEITVDRKIVFDAMKKDLTTVQQLWKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ45</accession>
    <name>A0A654DZ45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketosteroid isomerase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024850822" evidence="1">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15670" checksum="B2EFBDB5466B072C" modified="2020-04-22" version="1">MKTFALVFLMIPSLALAQTENEIRAVLSAQVDCWNAGNIPCFMEGYWKSDQLVFVGKDGLTYGWQTTLERYQRNYPDQATMGQLAFDILEIYPLNTDYWFVIGQWSLERSAGNASGHFTLLFRQIDGEWVIVSDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ72</accession>
    <name>A0A654DZ72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5030" checksum="70B7EBCC2111A726" modified="2020-04-22" version="1">MSLSTVIPAQAGISFSQNFSGPISGIALLFDGAQSDNAQRHFVVKMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ75</accession>
    <name>A0A654DZ75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="445" mass="49031" checksum="A888F629344595AF" modified="2020-04-22" version="1">MFEESRKIFIAFMLSVIAYTAGATHIAGGYISIKKVEGTTVTFSVCGFSDAASSVHFGSGVLSFGDGAVNSAEVVVNRKPISDHHDLVAFEVSHTYAAPGAYKVSYVENHRTEGVMNVNNSGNESFYIETTFLIDPFFQNSFPVFDASHLLLAANAGRFAQALQVNDADGDLLVFSLVTPKKGRDMPVSGYHFAGAAMDPFTGNMSWDVGDHPSGHEPLYTFAIQVEEMREQEGSWFTLSQTILDFNAEVIASSLDHPTLEGVLSVCDAEEFYLKVQQVDQCSLQVELPFYQLLDGSTSASLNDLSIHKDTIFYFDLIPSTKSYDYGHIRVHSEGYVQSRNVFYSQDCESFTAIRSVVTGAPPHSEDISVYPNPSDGDFKINDRSGNLSYYKIITLSGKQIYAEMVQNPLVSLSHQGNLQPGTYIIQFFDGFDRLIGVKKLLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD0</accession>
    <name>A0A654DZD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4652" checksum="A7EAEB50ED35AAD0" modified="2020-04-22" version="1">MRLEGKEPGGEGIISLLKTNIISFNAKNIRFVNYEFYSASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL5</accession>
    <name>A0A654DZL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/pantothenate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="504" mass="55386" checksum="DF19C2671EB217BB" modified="2020-04-22" version="1">MNNLASSEQIFATWIVVILYMLVILFFVIRGALKVKSMSDYAIGSISFSPLAVGLALAASMTSAATFIINPGFIALYGLSGVLSFGVVMPLAIFCSLILLTKKFRKSGSYVKALTMAQWIGKMYQSQNYAIFFAFISLLLVTFIVLICVGLTQVLASTLNVEPVIVLLSVIVFVFGYMMFGGANSMVYTNAIQATLMLVVAVILLFSGMEYFQDGIGGFVKKLESIGPHYASLTNPDSFLFRDFFEIIFCQAVIGVAIVCQPHIITKSLLLKDEKDVNRYLIVGILVLLVFFQVVFVGLFARLHFPDLTVNGMPIPMDGIVSAYVVSEFSVYVTILVVLGLISAGLSTLEGLIQSLSATLTADLFNPLFGKIYDPVKRDKQEILVNKLMIVFLAIISFVLSYRQLKSPNLSVGIFAQNGVYAYFSSAFVPVLFGMFLKDVRLKTVFTSSIVAFLVHFTVYYGRFLPYMKETVNNPAIASTAALIVSMIVGLSMHLYLKPSQNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN9</accession>
    <name>A0A654DZN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Cyclomaltodextrinase</fullName>
            <ecNumber evidence="5">3.2.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047798">
        <property type="term" value="F:cyclomaltodextrinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031965">
        <property type="entry name" value="CBM26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16738">
        <property type="entry name" value="CBM26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024980585" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="769"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1142" mass="122175" checksum="B9F4EE9DBE0AA7F4" modified="2020-04-22" version="1">MMKTLYSRLAGLWLLILMTISQLALAQDPAQYGTPFAGVPDRMDANIYQMNLREYSSSRDIAGARANLQRVRDLGINVLYLMPIFPVSTDSQASGSPYANSDYKSVAPDLGTLNDLRGLVQDAHNMGMAVILDFIVNQTGWDHPWVSQHPDWYIKDGSGNTTSPCPAPDFCFGDVAGIDLTQSGAANAMVDAMRYWIFAANVDGFRFDWADQPPQAFWNSAISNLRGISTHDLLLLAEGSNEGTNSGCTTCGQNQPGAHYAQGFDYIFGTNFYWNVMKKIWNSGEPVTNLDGVTAGEYNGASSTQLVARFLSNHDDYNADGSPFSFLNGGRNAVMSAFALATYHRGVPFVYNGIEVGNTNPLTYPWNSGTINWSQDLTVYTEMQKILNARNNSVALRRGQPTSYIDPANTNPNVIAFTKESGGEKVAVLINPRGSNSTFTIPSGMAGSYTDIFNPGTSVSWTTGQNVTLTPYQYIVVSNGNVPQVDVIGIAVNPASASIYAGLTTQLSASVQPSNATNQNVTWSSSNTSVATVNTSGLVTAIAVGTATITATTQDGGFTDTSVITVNTAPSFTVHFYRPSAWGTGINIYWWAAQPSGVLADGSWPGVAMTNEGGDWYAHTFTNVTTTNLIFNDGTSQSADLSRGSDGWYQNGIWYNSNPGACSPTAITPYTQVNGGAWNQTASATLDAGGSVAFGPQPTSGGSWSWSGPNSFSATTREVTLTNVQVSQSGNYVATYTNVGGCTSTQTFSLTVNSIGQTPFGGSARAIPGTIEAEDFDNGGEGTAFHDNDASNNGGQYRTSEGVDIEACSEGGYSVGWTNAGEWLEYSVNVSAAGNYDIAVRVAGAVGGTVRLEFDGVDKTGNLTVPNTGGWQSWQTVTATGVSLSAGSQIMRIYMNSGGYNLNNVTITTASGGGGGSAYRIKNRWQGTYLYDNGSQAAYGNPSVGDQSSHWTLESVDGHTAIKNVATGDYLNIETLQSYVECTNIGTGAWSAQWALEDFDGHKRIRNRWQSGDYVHIENLTGYAQHGSVYNGAYSGHWTLEAVSGSRLGAELIPTQVFSSSVAVYPNPFTSQVQIKIQSQEGKDHQISVWDMSGKQVLYQVESADEHGVVNQLLNTASLKAGIYFFKVQSGEQLKTFKMIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZQ1</accession>
    <name>A0A654DZQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-formylglutamate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007709">
        <property type="entry name" value="N-FG_amidohydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05013">
        <property type="entry name" value="FGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="28819" checksum="36D7003AA1360561" modified="2020-04-22" version="1">MPSSGSAFHSMNKVTALITCEHASNQIPPRYRGIFSEAHTDLQTHLGWDPGALDLARIISGQLKVPLTTYDYSRLLIEVNRSLDHPQLFSRYSGGLSEEEKEQLKCTFYQPYREGVEAQISHLIDQGHQVVHLSVHSFTPVFFGQKREVEVGLLFDTTRTSEAGFCLKWQEELRRIRPQLVIRDNEPYAGADDGFTTYLRTRFLGAQYLGLELEVSQAYADQMQDGFGADISESFCQTLALWRSDLDMDQKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV6</accession>
    <name>A0A654DZV6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="33674" checksum="BFADB4A8F6A52D7D" modified="2020-04-22" version="1">MTTAEKRVLVLCPNAAIDIFAWVEGFTQGVPNRILKETRYPGGKGLHVGMALSELGIPVTIAGFWGGEAGIWIKKACNEYYPKIEFIGPDISEWSRSCYTFKSRGDFDDTEILGPGPVVTDSDFRHLMDSIETMLSNTALIALCGSWPKGSPENGYQQVIELAKKASVRSFLDCTGPQLANALKAQPYGLHLNRKEITEYFQVEFDTAKKQIMEYCDLAAITDGSKGLYLISENEMHHALAKIEEVISTIGAGDCLLAGIIAGVLQNLPHQSIANLGAACGAANCMRADLGMLHKEDVERLLAVMAEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E036</accession>
    <name>A0A654E036_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024826846" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4597" checksum="262DF839A24A9FA7" modified="2020-04-22" version="1">MKLKFVIIALVILGFSACTQKTCPTYANVDVEQQPVEEAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E077</accession>
    <name>A0A654E077_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine kinase</fullName>
            <ecNumber evidence="8">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_120237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="552"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="4">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="875" mass="101276" checksum="195AF9A5D19C679A" modified="2020-04-22" version="1">MRILYDLPIRTKFAVVLVPLIVIIICFDYIQIKHNYLDYDDSQRLNKTILLGVEINHAVHELQKERSISVGFLTNDGEDFSQALLHQRHVTDSTLERFYEELDRLDLKGIFAIHANDVELLNSNFSTINSIRQKVDRRVLDPIQILEYFSDIDEVALNTVDQLINETRDKDIAQQVHALIYFLKAKERASIERAIGTHAFSISEIDDETYSSFTALVAEQEAYTDAFLIIADEASRGVYNNLVTGHDVNEVDRLRSVLHLRDNFNQDPGYWYEMTTSKINALKRVEDSISQRLLSRTEYLARTAFQKFWTFIVLDIIIGILAMWLMSIIVTNLLANVKILERFTIRISKGDLSKKVFIATKDEIGQYAKTFNVMVDEIVKSHNILRKERDKAKFLYNNIYRVSLVVFQNIHQGIFLLDRNFKMSKLYSKSMEKIFGLSKISGENFANFMRPLIIPRDLEALEMFMRHLFNEDMDEDVVNQLNPIEQVKIYSETDGIVTTKYIRVNFTRIWRRDRIANIMVTVSDETESVLLQKHLEDAEKKKKQETEQVLSILKIDPSLIRGFLYNAKRTLKGISERYEANKDRDLKALLDFTFETIHNLKGNAVVIGLDIMSEKFHEVEEAIESLKLKEVTGKDFLTILYEIDDADKMIDEMSSMLRKVADIYRKYPSGGHVVSNIMLIDNLERSVKLLSDKMDKPVDFFFKNESNLVLPNEHIDAFRDIMIQLIRNSVKHGIEDRETRTSLGKLIRGTISIELDQPKDQRFEICYMDDGRGLDVIRVKQRAVQSGILTEFEAEKLTHDQVINLIYEKGFSTATEVDENAGRGRGMNLVKTLIEEMNGTFTTTFEEGKYFKLIINLPISGIVEDQSKEHETTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E081</accession>
    <name>A0A654E081_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="161"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="335" mass="37745" checksum="4A5CE32045829220" modified="2020-04-22" version="1">METTKNSISFEGKKLSVQKRLLVALGVIVTIGIFMRFINFPNSSRSSSAENRAEMQPAGLPIVMNDSLIRPLTTLLNSSLQKDLDGIIASNKKWATLASQKKMCIGLVDLRDSYNVKFARVNGNDMMYAASLPKIAVLLTATESIDQGLLEETDEIKSDMRMMIAKSDNAATTRMIDRVGLDKIAEVMQDPKYDFYDEEKGGGLWVGKRYASTGPRNGDPLKNISHGATATQVCRYYYLLAFGQLVNYERSKQMLAYLGDPMLHHKFVNTLDQVAPRAQVFRKSGSWRNYHSDSALVWGPTWRRYILVALVEDEDGEKIMRELIMEVDKKLKPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0R4</accession>
    <name>A0A654E0R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="14759" checksum="16FADA84908E7716" modified="2020-04-22" version="1">MLDFQKKKQLSILVKIAMVDEDFADAEKEVIRKISQKYGATSQELTEIFDSPATAESLAPMTLIDKMDFMMDCILVVIADDMVTSSEEYFARQMATRLGFNQDVVAFLIKNKDVSREEMRELMLPYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U4</accession>
    <name>A0A654E0U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12803" checksum="56BA1954A8E39ECF" modified="2020-04-22" version="1">MNIENTQVQMRKGILEFCILHIIARGEVYASDMLEELTSAKIMVVEGTLYPLLTRLRKAGLVDYKWVESNSGPPRKYYTLTEEGTSFLSGLDQTWEELVSSTGRIISVNKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0X7</accession>
    <name>A0A654E0X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="20430" checksum="746F103F464FBD86" modified="2020-04-22" version="1">MKDILRRHSVLKEDIVNTINKQIKMEAQSSAAYLAMAAWCDTRGYDNCAAHFFKQSDEERKHQMKFFRYLTDMECDAISPSVGESQHEFASLRSVFETALEMEIAVTDSIHDMVRVCRKEGDIATEEFLRWFVQEQIEEEFVARRTLELFDVLGEDKIALGMIEERVLTIEYSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E128</accession>
    <name>A0A654E128_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="22834" checksum="62AD88AD85E220D5" modified="2020-04-22" version="1">MNTNLTMLRIDKSNSEQKLLHDCKKGRPSAQKELYDRFASRMLGVCIRYIHDREEAEHVMIGGMVKVFDKLEQYQGEGSLEGWVRRIMVNESLMYIRKHKNMSLEVEVEKAESEPDYSTLENSLEAADLMALIAELPVGYRTVFNLYAIEGYNHKEIAETLGINENTSKSQLSRARKYLQNRLATIQEKELKQDGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F0</accession>
    <name>A0A654E1F0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpsN</name>
        <name evidence="5" type="ORF">MARINOS108_120484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="10237" checksum="726D8A11802F671F" modified="2020-04-22" version="1">MAKESIKARERKREKLVARYANKRAALKEAGDYEALDKLPRNSSKVRLHNRCKLTGRPKGYMRKFGISRVTFREMANDGKIPGVTKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F9</accession>
    <name>A0A654E1F9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="23409" checksum="30029743CD7CB7DF" modified="2020-04-22" version="1">MSKKILLTGFFALVFLSALYGQTHWLGLGPSVPLADFGDADAEHPTSGMAATGMALGYEFIGPTDSLGLAIFFNASFIWNPFDESSEAQIESSMRSPPENLKYSHYFGLPMAAGVNFSPRNTWQVSAGGVISFFKPTAMVIGRDVYKIKGTTGFGLTLGASLRIGSRVALKARYYWVTNHRLKNGYYRYYNSPENKVQNVNELTAMLAFRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K7</accession>
    <name>A0A654E1K7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ORF">MARINOS108_120485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="20432" checksum="7D883036110C3DEF" modified="2020-04-22" version="1">MARPRLKEKYIQEIAPALKEKFQYKSVMQVPKLVKISVNKGIGAAVADKKLVDVGVEELTTITGQKAVPTVAKLSISNFKLREGMPIGARVTLRGDKMYEFLDRLMTVALPRVRDFKGIKQKGFDGHGNYSLGIEEQIIFPEISIDKINRITGMDITFVTTAETDEESLALLKAFGMPFVAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U1</accession>
    <name>A0A654E1U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5679" checksum="BB0299B25826E6EF" modified="2020-04-22" version="1">MLCKHTKFPQKGCVIRRYEYVIQMKLLFIIVVIVGLYLSHLDILAGNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X9</accession>
    <name>A0A654E1X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="109" mass="12108" checksum="9332DDCD2394B5F2" modified="2020-04-22" version="1">MGVTKTDLFTREQNELATVAKVIGHPARIAILQHVLKSNQCINSDLVKDLGLAQATISQHLKELKSLGIIRGTVEGTAMCYCVDGEVWEKISKDFQKFFGTYDEMKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z1</accession>
    <name>A0A654E1Z1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">iscS</name>
        <name evidence="9" type="ORF">MARINOS108_140037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="4"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="41976" checksum="DA8BB424764CE794" modified="2020-04-22" version="1">MKKVYFDNAATTPLDEAVFEEMKPYMLEYYGNPSSIHWHGRQVRSAIEKSRKKVADLLNTSPSEIFFTSGGTEADNTAIRCTIEDYGVKNIITTPLEHHAVLHTVEMLAKKGNVNLHLLDVDEKGQISLDQIEQLLKKDPNTLITLMHANNEIGTMNDIHAIAEMSKAYGSVFHTDTVQSMAHFRHDLQQLKANFVVGSAHKFHGPKGVGFLYVNHEKRIQPFIHGGAQERNMRGGTENVYGIIGLAKALELAYAHMDDHKKQIESVKSYMIEQLKLHIEGVSFNGTSDDLENSLYTVLSVSLPPSEDNDMLLFNLDINGISASGGSACSSGSNIGSHVLTAIGSDPQRGAIRFSFSRFNTKADVDYVIGKLNEILTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E214</accession>
    <name>A0A654E214_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F0F1-ATPase subunit (Ca2+/Mg2+ transporter)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="8576" checksum="E068BD14F2C8704D" modified="2020-04-22" version="1">MAKQKKDPSSKHNPKVDNTYARISGITFELLAINLGFILGGYYLNEKADPVFPWILLLGVFLSVAATIVYLIKKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E224</accession>
    <name>A0A654E224_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">MARINOS108_20183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="26503" checksum="33382E10E7724DBD" modified="2020-04-22" version="1">MKLLEGKTALITGASKGIGRAVAMKYAEQGANVAFTYLSSVEKGEALTKELEAFGVKAKGYRSDASDFKAAEELINAVVADFGSLDILINNAGITRDNLLMRMSEEQWDEIMSINLKSCFNTVKASARTFMKQRSGSIINMSSVVGVKGNPGQTNYAASKAGIIGFTKSVALELGSRNIRCNAIAPGFIETEMTDALDEKTVQSWRDAIPLKRGGQPEDVADACVYLGSDMSSYVTGQVLQVDGGMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E231</accession>
    <name>A0A654E231_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="75" mass="8529" checksum="CBAEEFE9141A649B" modified="2020-04-22" version="1">MEWREHVISDNNVLLGKPIVKGTRVSVEHIIGLLAQGWTEQQILDNYPRLTQESLQAVFAYIQECLKDGLLHSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E253</accession>
    <name>A0A654E253_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_140107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="9">
        <location>
            <begin position="66"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="8">
        <location>
            <begin position="426"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="759" mass="85513" checksum="150E59853EFB8B00" modified="2020-04-22" version="1">MNKRTLRIIVIVLWVLFLGAAITIPSLFYMVKHDTNGWFGDLPSLQDLEKPDPDLSSELISADGVSLGKYYRKNRTPVTYEELSPALVNTLLVTEDIRFKKHSGIDLKGLLRAVIGKLTFQFNGGGSTITMQLAENLYSTSSANRGSLYKYSSVGQIITKLKEWIISVQLEQSYTKEEILAMYLNTVEYGSNSFGIKVAAKTFFNKLPSQLNYSESALLVGAINAPTRYSPIMNPDNAMAKRTEVLYNLHKYGLLTRDTFDSLKTTDFGLTYLVDNHNEGLATYFRFVIRNFLLSWTKEHGYDLFEDGLKIYTTIDSRMQEYAEQAMKEHMDTLQSIFDDHWATLKSNPWIDDNGNEIEGFIENAMKRTPQYRALVSNYGKESDSVEILLNKKKPMTVFSWDGEIDTVFSAYDSLRYYKKFLQAGFMAMDPKNGNIKAWVGGINHKYFKYDHVSQGKRQPGSTFKPFVYTVAIDNDYSPCYPVVDAPVTFAMPGQDPPTYTPDNANGKFSGEVMTIRQAMARSVNSITAFVMKQVKPETVIEYARRLGIESPLAPVPALALGAGGDVSLQEMLAAYSTFVNKGIYTKPFFISRIEDENGNVIQQFVPETREALNEETAYLMLHMLKGTTEETGGTGLSIDRELRMDNEIAAKTGTTQNASDGWFMGVTKDLAAGAWVGGDDRSIHFKYWAMGQGARTAMPIWEKFMLKIYADPTLGYQKGPFDKPLKPISVELDCDKYNDVLQPTDSLRFDLIDEDDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E259</accession>
    <name>A0A654E259_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 12">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MARINOS108_20275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 12"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="13">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD18523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="32164" checksum="D750B086E09CBAED" modified="2020-04-22" version="1">MKTWEGLGYYSRARNLHSTAQVIHEELGGIFPSTYGELVKLKGVGPYTAAAIASMAFGEATPVIDGNVFRFVSRYFGVEADIADQKNRKFFMEILEDLIPQSDPGTFNQAMMEYGATVCKPSPDCANCLFRLSCYAHKHQKQQVLPVKTKKVKSKEVFFSYLIFEHEGTTLMRQRTESIWTGLFEFHNITHEQGLQEEQITHFLSQYPHLILHQKFEPVQHILTHRKLWVTFYHIEVTMKDTFRMLSKDLGLNLYSWEEVLTLPRPKVIVNHLQQAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E268</accession>
    <name>A0A654E268_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21267" checksum="F2F7AF0BD257CBC9" modified="2020-04-22" version="1">MKNHLPLFALIALLLVVSCKDKEEPAPPHEVGVWALDSYLFINFPSEFEGYEGLAYDIDELSFGNGVVYDDYTLVLEKDGTYSLEIGVTGPDINDAGTWEIDDDELKLESTEDNDDQDWTIEKNEEDDLWLSFETQSAFIPDIYFDTVTQKYIDYLNTLTDQQLDSVSNAISRVVSFDLVYVFERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A7</accession>
    <name>A0A654E2A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="16455" checksum="CAC01EBFD204932F" modified="2020-04-22" version="1">MNFFKAAVLIAFFAFGTDANSQRKIKKIEIQESGYNVQLKLIPQSSHTSYDGLSIKINPISASDLNREFMNQCHLNGDFNYSYYEKSRSTYFLKKRKIKREKSNSEFILEGAEWLFENEKITFRDSQLIGCMMRVVWIMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J0</accession>
    <name>A0A654E2J0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline-glycine betaine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="500" mass="55003" checksum="6BD68749F861979C" modified="2020-04-22" version="1">MQQLNPIKFWPPLILLTGTVIYSLLDKEGFLAAAQSINTWILEHFSWLFSWSVLLFVLLLAVIYISPFGRITIGGKGATPLLSKWKWFSITLCTTIATGILFWGTAEPLFHFHQPPASLDINPASVEARNFSMATMLLHWTLSPYAIYTMAALVFAYCFYNLQRPFEVSATLFPLIGKSSSEIIGHLTDIICLYGLVAGMAASLGAGILTISGGLRLFLGIPPSSFLPLIITITIVGTFVASASSGLMKGIRVLSDYNIKAFILLAIFFFCFGPTMPILETGSSAVVAYVQNFLPRSVNWNHALDQSWFQSWTVFNWANWLAWAPITALFLGRLGKGYTVRQFILVNLVFPSIFGGLWMMIFSGSAIHFDTLSNGALFQILTDKGPENVIYAIFESLPFTRLISIIFLLITFISYVTAADSNTSAMSNLCSKGITTEHQESPVFIQVIWGTIVGTLAWMMISYSGIEGIKMISVLGGFPALFLVIAISLGALQLMITTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2J5</accession>
    <name>A0A654E2J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="26652" checksum="50CDE7E111890DDA" modified="2020-04-22" version="1">MVLMILILFLSAVLGGVSSKFFGHHTQSIRYPLIFAGSFLFSVTIIHILPEVFSLSEDPLEVGLYILFGFFFQQLLEYFTSGIEHGHTHAHDEITGTSKFGLLIALVIHSFLEGALLTHDSPFHERHESYSLLVGIVLHKMPAAFALVTTLRTSKGFDGRLWGILLIFSISSPVGFLMSDQVLNLSPEVLLLLFAFVSGSFLHISTTIFVESSPNHHFGLKKFLISLFGAFTAIATEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R6</accession>
    <name>A0A654E2R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="39734" checksum="A814209D7C422722" modified="2020-04-22" version="1">MIDPQEEHQNEDLFEHHHIIADPKQAILRVDKFLMDRLPNVTRTKIQSGIKDGFVKVNGELVKPNYKVHPGDSIHIYLSEPPRDEDVVPEDIPLNIIYEDKYLLIVNKPAGMVVHPAYQNWSGTLVNALAYHFQNLPEMEGNEGRPGLVHRIDKDTSGLLVIAKTEAAMTGLARQFFDHSIERTYYALVWGEPEPTKGTIDVFVGRSLKDRRITTAFPEGDFGKNAVTHYETVKQLRYVTLLKCNLETGRTHQIRAHMKYIGHPLFNDATYGGDTILKGTVFTKYKQFVHNCFKMIPRQALHAKTLGFIHPITKEPMRFDSELPEDFTQVLEKWENYVNHYDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U6</accession>
    <name>A0A654E2U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="463"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="681" mass="77199" checksum="824FC8598258084B" modified="2020-04-22" version="1">MLSEKLKIRLSFLAGILSWLLFTFFDLYLLFVDQYQLNVDLSAILPQIFLTTLVLSTLSYYRYTITKADSINFIDLLWRVFITGLVTTIGSLFIRLFFYIFGNSTISENPFTVNFLYNILIGLVVVYLVSTFVVWKRLILYQKSKNLIQLWGFFEYALLGSLIFDLFGNKFLSVNFNTALIFLGGLGIILAFNLKWIAYLNFKQKWKSILFIILSGIYLYHFLLNLMNFSETGALNLDLLDRAYFVSLFIFIILYAGISILVTLFNLPTSSVFERKLQEAIDFQKLSQSIPAGQSAEQTYDILLESSMSAVFADAAWLEISGEEPILLTRGVTTLTVKDIKESVRQDFIKKILSQQVSNEFAPSKVIGTLNHPDFKSIIAVPVMVQNEQIGSLALLQEVGDAFNREMVDIITTFVNQASISIENFHLIREALDNERYKEQLKIAKSVQKSLLPSVLERNDCFEIEAYSMAADEVGGDYYDIIEPSKDIFNLIIGDVSGKGTSAAFNMAQMRGIFHSLAQDVSTPKEFITKANSAIGRCLEKNSFITAIFFVINTREKKFCYARAGHCPAMYYSASTGNITLLEKEGLGLGILRNSQYNEYVQEETINYQPGDLLLLYTDGISEAKNEYKKQYGADGLKSSLQNHINAPLGKLKDMLINDLLKFLNGNKLDDDYTLTIVRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E346</accession>
    <name>A0A654E346_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031566">
        <property type="entry name" value="CitMHS_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16980">
        <property type="entry name" value="CitMHS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="497" mass="54660" checksum="7A7B509586C77445" modified="2020-04-22" version="1">MNKYLKLFLFAFAISGSIIGYEASASDLSQDHQEVSSEATDETVSGDHAEEAHHGPAGWSVIPFAVLLLMIATGPLFYEHFWHKNYPKVAVALAVLVVSYYLFGLGNHHSPVHALFEYVQFIALLTGLFVASGGIMIIVDKKAAPLTNVALLAFGAIIANIIGTTGASMLLIRPFIRLNKNRIKSYHIIFFIFVISNIGGSLTPIGDPPLFLGFLKGIPFFWTLSHNLLPWIFAVILLLIVFYFMDKGNKADYSFGEEIATPTGKIGLRGSRNFIWLAVVVGAVFLDPNVFPWVPGIHYEGQKFSYIREIIMLAAAYLSYRFADKQALSGNDFSFEPIREVAFIFVGIFGTMMPALELVGNFAKSPEGAALITHNTLYWGTGLLSGFLDNAPTYVNFLTAGMAADGASINKVSEVIGYSQGAYANSILELKAISIAAVFFGAMTYIGNGPNFMVKSIAEQVGIKMPSFFGYILRFSIPFLVPLLVIVWLVFFYFEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E354</accession>
    <name>A0A654E354_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024953917" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="117"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1101" mass="121893" checksum="5016CD1492F43B4F" modified="2020-04-22" version="1">MRFLFILSVLFSAVSLQVSAQSIALSGKILDQSGEGLIGATVQVKGETSGTVTDLDGTFRLSVAQGQTIVISMIGMESEEYLVKSSRPITIQLKEATAVLGEVVITGFQEVDRKLFTGASESLQMDDIKVNGLTDVSRALEGQVAGVNVDNVSGTFGTSPKIRIRGNASINGNNQPLFVIDGVILEDLANVNTDDFISGNANTLISSSIANLNPNDIESFQILKDASATAIYGARAANGVIVITTKRGKSGKLRVNYSGNYSFKLRPTYNQFNLMNSAQEMSVYRELYEKGLVDITTSVRAQNYGAMGKMFTQIANHELEWGPGGTLNEEFLNTYENANTDWFEVLFREAALQQQHSVSFTAGSEKSNSYYSISFLNDQGQTIADNVQRVTASSRNTYFLSDIFTFGLKLSASYRDQRVPGTRNREFDPITGRFSRNFDINPFSYALNTARSIRPYDDDGNLEYFRRNYAPFNILEELQLNYIDITVSDFSAQTDFEVNPSKNLSFKGVLQARYANTVRDHTVHENSNQAEAYRANGTQFIQDANNLLYRDPDNPGLNPVVVLPQGGFNYLDQSELLNFYARISADWNRTFAEAHEINVLAGQEIRFSNRTESSTTGMGVIYESGGIVITDPNIIEFFNLQNIDYYRLSSSKDRFLGLFVNGGYAYKSRYIANFTVRYDGSNQLGESKAARYLPTWNVSGAWNVTNESFFNVPFIDNLKLRGTYGISGNLPPNASALLNLQADVTVRPTDVEPYLYIQDLTNTELTWEKLKELNVGMDIAVLKNRVSGSFNYYRRNAYDLIGTVQTSGIGGQGLKTGNFADMDADGFEASISTENLQGRDFTWRTNFNVGYTIDKITRLDFGPRIADAIGQNGAAVLGGPRRGLFSTRFAGLNEQGVPTFYDENNEIVYQYDLQDRGSLTSTLKYEGPVEPRGAGGLTNTFGYKGFSLMVLLSYKFDYKIRLNDAFFATYTDFDALPAELINRWAVPGDEELTDYPVILDRGVAQSNGNVVLAYQLYNKSTARVANGDYLRLRTVRLSYAIPPALIGRMGLSSASLSLEGQNIALLYSDKKLKGQDPEFFSSGGVSLPQPKTITFSLNVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E382</accession>
    <name>A0A654E382_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37448" checksum="4FF3A9D41B27E5A0" modified="2020-04-22" version="1">MAKVFAFEVLKFASSFNKSKNMDSIIITGATSGIGFHCALQMARIAKNEQIIIPARNVRAGKEVVERIKDKTGHKNLKCLELDLASLQSISQFSEILAKEKRLSISILINNAGVQNIGETQYTANGFERTFGVNHLGAFALTIQLLSLIKDDGHITFTSSETHDPALKTPIEPPIYTSAHELAFPTETFEKQNTVGQRRYSTSKLCNIMTTYALQERLKHTNIRVNAYDPGLTPGTGLARTYTPVMRFLWKNIFPVLTLFKSNIHTPAQAGRNLANLAYAERYNDLRGIYFSDGKVFKTSVDSYNKDFQKDLWSGSLELTKTTFTEETFKKGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E397</accession>
    <name>A0A654E397_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlA</name>
        <name evidence="7" type="ORF">MARINOS108_20553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="31767" checksum="D4D2ACED5643FEDC" modified="2020-04-22" version="1">MKGIILAGGSGTRLHPLTHAISKQILPVYDKPMIYYPLSVLMLAGIREILIISTPRDLPVFEELLGNGENLGCKFSYAVQEKPEGLAQAFIIGEEFIGADTVALVLGDNIFYASGFSKKLQACADPTGGIVFAYHVTDPQRYGVVDFDEHGRVLSIEEKPANPKSNYAVPGLYFYDNEVVGIAKSIKPSSRGELEITEVNNQYLKAGKLRVEKLDRGTAWLDTGTFKSLMQAGEFVRAIEERQGLKIGCIEEVAFKMGFITQKQLEALAEPLLKSGYGEYLLQVPKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C0</accession>
    <name>A0A654E3C0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="34163" checksum="186D182D1C83D138" modified="2020-04-22" version="1">MKKLLFILIVALGISSCDDEVDIPLKDTTPFLNVDAWLTNTGDTQQIVLNYTRPYFDNGAPEPALAAEVIVVDIETLEPFVFSDEDDDGIYVWVPAPGEVFGEVGHSYGLQISVDGQVYQSFSTLNAAPSVDSITFEYNKKDAFIEEDYYYAEFWARDFEGPGNTYWVKSFVNDTYLGKPEQINIAYDAGFSAGGEVDSLIFIQPIRTAITPFPTETPAVSPFKRGDKLRVELHAIPIDAWFFLYRVQDETVRQPGFAQLFANPLANSPTNIVPTSDDVSVVGFFSVAGVSSLEVIMSDENIVDRVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E6</accession>
    <name>A0A654E3E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024916114" evidence="1">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23145" checksum="EF3D8E1527AC3582" modified="2020-04-22" version="1">MKTVLMILMLVAGSAAAQSKYEAAVLKGKDLLKAADDQEAYMGCANYFERIAQKESKEWLPLYYHSLSLTLWGTRETNPDTKEKVLNDALALVQKAKKIEKNSELAALEGFVQMMRLTVDPATRGQTLSPTIYALFGEAIALDPENPRAVLLMGQMEFGTAQFFGSGFEKACGYIQRAYDIFERTPDELTTLPTWGKGMAEASLAHCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S2</accession>
    <name>A0A654E3S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tuaD</name>
        <name evidence="12" type="ORF">MARINOS108_20496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="315"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="48312" checksum="5AB4DB31C07333FC" modified="2020-04-22" version="1">MKIAVVGTGYVGLVTGTCFAETGNHVTCVDIDEKKVQMLNNKQITIYEPGLEVLFERNIRQGRLEFTTDLKEGIKGAKIIFLALPTPPGEDGSADLKYVLKVAEDLGPILEEYTVIVDKSTVPVGTADKVHAAIAANAKVDFDVVSNPEFLREGVAVDDFMKPDRVVIGAESDKAKKVMEKLYGPFVRQGNPIIFMDVKSAELTKYAANSFLATKITFMNEIANLCELLGADVDMVRKGVGTDTRIGKRFLFAGIGYGGSCFPKDVQALAKSANQADYDFKILNSVMEVNQAQKERLIDPLKAYFNNDLSGKTIAIWGLAFKPYTDDIREAPALENISKLLSLGAKVKAYDPEAMENVKGVFGDKIYFAEDEYDALKDADALMIMTEWPVFRTPEFDKVEARLKNKVIFDGRNLYELGQMEELGFTYHSIGRKIING</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E440</accession>
    <name>A0A654E440_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ORF">MARINOS108_20626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="98"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD19238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="46816" checksum="47778894BEB70AD5" modified="2020-04-22" version="1">MMENFIEYLYSKFLQSDGVSIDTRTIQKDNLFFALSGPNFNANKFAEKALELGAAYAVVDDPAFATDPRIILAEDSQKALQDLAVFHRSRYKRRLLAITGSNGKTTTKELINRVLQEKYITHATVGNYNNHLGVPLTLLHIHPQVEVAVIEMGANHVGEIADLCRMANPTHGLITNIGEAHTELFGGIEGVLRGKSELFDHLRTTGGTAFINLDDFRLENMAKRFSDPVLFPASDLALIEANPYIKIKLGDLEAQTNLIGRYNYGNIAAAVAVGRAFDVSDEKILKAISDYTPSNQRSQVIKKGSITIINDSYNANPTSMKAAIDNLAAMPGKKAVILGDMKEVQDAVDRHLDVGRWLKEVGFDQVILIGRYMMAANMLVEGSFRFETVAMAKAFLETRSLADHTVLIKASRSMGLDHVMESLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G5</accession>
    <name>A0A654E4G5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF547" evidence="1">
        <location>
            <begin position="76"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="29454" checksum="96EE462D3A5E9BE0" modified="2020-04-22" version="1">MRVTIFLVGLFFINACGTLNPQQAKTKPVSHQIFDELLKRYVTDEGLVDYRGFITDSVQLTEYIDLLSNNAPNDSNWSEDDQIAYWINLYNAATIDLVLQYYPVESIKDIGSSIQVPFVNTPWDIQFIEIAGERYDLNNIEHNILRKKWAEPRIHFAINCASLSCPKLRREAYEGALLQRQLDEQAREFVNDHFRNDITTTGASLSKLFDWFGGDFRKKMPVKAFINQYSDVKISEEVEISYKEYDWRLNDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H2</accession>
    <name>A0A654E4H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="59"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="278"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="580" mass="63947" checksum="4A69D3FCA5ECDC26" modified="2020-04-22" version="1">MINNKEMKKSIIKSILFLTIASLLGACGESFLEEEPKGFLGESNLQNEEGINAALVGAYALLDGMNIDGANTWSANPQNWIFGSVPSDDAYKGSEQTDFAEMTQLEIYQWSAGNSIMNDKWVSSYEGVVRANSTIRLLGGADLPDAVRDNLEGQARFLRAYYHFELYKVWGNVPYFTEADEDFVKSNEGVDPLGDAIADMTAAVNLLPATQDDAGRATKDAARAMLGKFYMYKYGESGSAADASSAKDNLDPVVASRSLTPCFKDMFHTSTENNPAMIFSVQSSINDGGNSRNANWLNQLAFPAGSSFGCCGFHQPSQDLVNAYKVDANGLPMFDNYNDSELDPSTDAVDPRIDLTIGRDNVPYWDWDIHDASWIRDRAFSGPYSPKKFTHYKADPVSTGGWNNNAYNGINFSIIRLADAMLLLAEAEVILGNLSAAEDLVNAIRERAGNCAQGPFVDGGGAAVITDDINDPGIEWANYDVQPYPAGTFASNGSEFAMNAVRWERRLELALEGHRFFDLRRWGIAAEVLNKYTEYAAKTRSYYADAATYEARHRWYPIPTIQINANTRNGEQILKQNTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E573</accession>
    <name>A0A654E573_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folB</name>
        <name evidence="3" type="ORF">MARINOS108_20976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13146" checksum="E5F811DE14E8532A" modified="2020-04-22" version="1">MGLVSLEGMEFYARHGYYEEERKIGNKYSVDVQLEVDFAEAASEDKLEGTVNYEKVYEVVAEVMSIDAMLLEHLAGKMIRKLKEAFPKVSKVQVKVSKYNPPIKGLCHRAMVTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A4</accession>
    <name>A0A654E5A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-fructosidase, levanase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="46"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="375"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="510" mass="58582" checksum="FD4F8177161F06A8" modified="2020-04-22" version="1">MNQNTIPMKYLNAFIVLFCLMESCQFKQKAMNPEQTAEDRYQSVYHFTPPSNWMNDPNGMVYYAGEYHLFYQHFPDSNVWGPMHWGHAVSQDMIHWEHLPIALYPDSLGFIFSGSAVVDYDNTTGFGSELNPAMVSIFTYSNQQEEFEGSITFQNQAVAYSLDSGRTWTKYAGNPVLSNPGIKDFRDPKVTWMEEFEKWVMILAVKDHVSIYSSKNLLDWTHESDFGKDEGAHGGVWECPDLFRIQDDQGNWKWVMLVSINPGGYQGGSGTQYFVGEFDGREFSTNQKEVKWIDYGADNYAGVLWSNIPDSDGRKLFIGWMSNWAYANKVSLVNRRNMMTIPREVSLRRKENDHVLTMVPIRELDQVGVLNTSGDLTELEKGMRTNDAYRLDLQIESMEGKFELVFSSEDKDSLFLSVSHTELIVDRSRCGNVSLATMFSRQHKASLDGIRNLSIFLDRSSIEVFANDGEVNMTDLFFTRSPLQQVQMVTSEAEIEARFEYRKIEVKEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C6</accession>
    <name>A0A654E5C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="659" mass="76523" checksum="7C74A9146158190D" modified="2020-04-22" version="1">MSRSLTLFLIIISTIAFGQKRMVSINQEYEKAPSSIARSPIKLAQYLTENDSSEFQQALNIYTWIVNNIKYDVKALESIKSKTYSPKQTLKRKKGICYQYSALFASLCQNAGISSREVIGYSRGFIYHEDDPFFEADHSWNGVKLDSSWYLVDATWGSGVLHQKKRWFKELQFRWFKKPYINDKYKFKLQPNYDYFLVNPKSLITDHLPVDPNWQLVDFPISIITFESSAWKSYLDRIDSLYQKQIDSTEYVMKLDKYEYLSDLQYLQSTAEQSYLFNPKNSKLTGLSSYSIAKSYENASGSLTKRTEAYGHAIKLHKLAISHLKRHQKTATSESKELTRIVKIRISNELTQPINRRVKANDLQSKAALSFLNKEQKIFNNHKGQILKLQKAIARGYRPFVRPTPSRIEKPELVEKNKSEIENALTSVSNYQDSVRTLIKSIHLCTEVKRPLQKEIVSQYRKLPDYFTTNMKFITQNLGLNEVSKSMQAIDSIGQIIDSLSIEIKLIDRRVRQEKSLIKQLHSSIISQSAKMQKMIIQNCQLSKKETCEGVLYDSLSQGLKSIYEDKLHLESEYLQTAEYDGEINRRLKEITEEVNEVLITDSKCISLFQERRLSGISFKLQKTLFETDQLIDDSQKSVRRLGSKVFKLENEIRRSKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5P2</accession>
    <name>A0A654E5P2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="60" mass="6996" checksum="91EA240ADB264C5F" modified="2020-04-22" version="1">MICATFSFHLCGYPQYAISQQGGKTLFNLVKIRPMIYWNSFYAHFGQCDPLESDMRRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5V5</accession>
    <name>A0A654E5V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall bisynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="35"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="409" mass="46953" checksum="6912FB8D42C0C697" modified="2020-04-22" version="1">MRKHVVYLTYDGLTDPLGQSQVLPYILGVEAMGIHRFTIVSFEKPENFEKEKGVIQDLIRERQIRWIPNTYHRNPPIISTLFDVIRLWKKVRELVTKDSAEIVHCRSYVTALVGLQTKKKFGSQFIFDMRGFWADERVEGGIWNLKNPAYRLVYNYFKRKERLFLREADHVVTLTFKARDIINSWAIKPGDLPVTVIPCCVDMDHFDPEKVDPDHLKELREDLRIGPDEFVLTYVGSLGTWYMVEEMVMFFSKMLNSQPLAKFLLLTKDDPEGVLRIARRLKIPLDSIMIRPVSRSQMPAHIALSSFSIFFIKPVFSKQASSPTKMGEIMAMGVPIIANKGIGDSDNYISREMGVMVDVEGPAEINVSSQRLLAFSANSNLIRNRCKAVFSLDVGVDAYFSIYNFHSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Y0</accession>
    <name>A0A654E5Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="30572" checksum="F7944456BA33BAF8" modified="2020-04-22" version="1">MSDFQNSNTYEIKLPLFEGPFDLLLFFIERDELDIYDIPIAKVTSDFLDYLHQLETMNVEVASEFILVAATLMRIKAKMLLPRPVLDEEGNEIDPREELVKHLLEYKKYKSVIQELNSLESNRLDREQRGNLLKEIKKLSQSIDVEAEMQDLDLYKLMKVFQKVLKRYEFDQSRPTHQVVQYPYTISTQKDYLIQRLHSSPNHRISFSSLVEEKPEKILVIYNFLAILELLQLGTITLHIGEGFNNFWVEKLEEEKIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6A8</accession>
    <name>A0A654E6A8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="407" mass="46710" checksum="DF4B7714177E8086" modified="2020-04-22" version="1">MAKCFALIGWSLPVIESMQKLGKPYVVVSFADFEPYAKENDIPFVSYQLDEWSDTSNSLDLVEKLKPFDADVAVPLYEETVEWAGALNSIYRGDPRVLNRAFLFRNKAMMKRKALIGGLRVGLFEEVHNKEGVKAFMKRLNEANLQLEGEEDSWVHIKPFASAGTVGHRLLRSMKDIDEKCEDGDFPCLAESHLSGREFSCEAFIHKGKIRFLNITEYVKLGYSNFIPEGNYLRSKRDLIHQHVQKLVDIFGIEYGMVHPEWFLTDNDELNFGETACRIPGGHILELASKSWEFDALAAFVVSHDPNATEEELDAIFPAKDFKPKNYHGNVMIYPRKRQFSKLEIPEELNNEPYFVDHTLVPPYSGQKLSDSREGFGNHFGTINFKGEDPDRMTELLQHYEEVDFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E783</accession>
    <name>A0A654E783_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024821935" evidence="3">
        <location>
            <begin position="21"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="637"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="727" mass="79550" checksum="1EAD4D56448DED95" modified="2020-04-22" version="1">MMKKLASFLLIVLAAISHNAESQDYLETSLTNAARAKDLVSRLTLEEKVQQMMMNSPAIERLNIPPYEWWNEALHGVGRSGVATVFPQAIGLGATFDEELAYRVSSAISDEARAMYNASLKKGYYNRYNGLTFWTPNINIFRDPRWGRGQETYGEDPFLTTRLGVSFVKGLQGEDSRYLKTAACAKHFAVHSGPERLRHEFNAVVSKKDLYETYLPAFKALVEADVEAVMCAYNRTNDEPCCANNYLLQEVLRGEWDFDGHIVSDCWAIVDFYSENGHGTVENQVDASALALESGVNLNCGSTFPALVEAVNQGLIEEKTIDVALTKLLETRFKLGMFDDSNANPYNAISLDVVNSPAHRALAREAAVKSIVLLKNNGVLPLANDLSRYYVTGPNAAGIDPLIGNYYGVNPDMVTVLEGITAAVASGSQVHYRAGTLLDRPNVNPVDWSSGVAHTSDATLMVMGITGFIEGEEGESIASAHYGDRLDYDIPANQIDYLKKLKADNDKPVIAIVTGGSPMNLSEVHEIADAVLLVWYPGEEGGNAIADIVFGKASPSGRLPITFPKSLDQLPAYEDYSMMGRTYKYMTAEPMYPFGFGLHYSKIKYGTPAVTRSVIKSGESAEVSVLVTNEGDFDVEEVVQLYVTDVEASVSTPLFSLQSIRRVKLAAGESQRISFTINPEMLQVVNEKGETILEKGDFKIHVGGSLPTSRSLELGASVPVSVNLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7E6</accession>
    <name>A0A654E7E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="49"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="362"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="489" mass="54857" checksum="CB7093A5D5247195" modified="2020-04-22" version="1">MKRFYILLISLSILTACELDQLPSDGIVNESLASNYEGLVAATNGNYAMLKKLIVYDNKEYTANYWVRNDHQLSEFPSDNVMISGSTTDPLFYAFTREHIATMENTSYVWFSSYRAINGCNQIIGAVDESSSDNFRQLLGENYFLRGLLHLSLLKLFALPYSHGVDNPGIILKTSLADEPTEARSTVGQCYAQVEADLLKAEELMSGGRGSAYASEGAAQALLSRVYLHMEQWQDAIDYADKVIDGDDFSLVSRADYLNSFWNGSESEEAIFLVAHLLQDDHASASIGSMYLTDQGQGWGEVYASEPLRDFLLQYPDDIRNDFIVPDLEPDGVTVKERNGFPKYFITKFSYQDGVVTLNSPQLIRLGEVYLNRAEAYAHLNNAAQAIADVNVIRERAGLTGTALYTTTDLKGFASALEVVLHERRLELAWEGFRLTDLVRNKMNIDRSYPGMHLDEGQTTQVIPWDDPRNIYFIPSNEIANNPLIKQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7J8</accession>
    <name>A0A654E7J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase D (Modular protein)</fullName>
            <ecNumber evidence="7">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024876288" evidence="5">
        <location>
            <begin position="34"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="458"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="884" mass="93430" checksum="5A59085BE1D2DD98" modified="2020-04-22" version="1">MNTFYQPKPIFLSCLWKVSLLIALLFLIQSAQAQVNCTGLPAWSSAAVYTQGDQVQHNNTGYEAKWWTQNEDPATHSGQWDVWINLGACGSGGNTPPSASITSPSNGATFTVGATININASASDPDGAVSKVAFYQNGNLLGEDTSSPYSYSWSGAAAGNYNLTAVATDNDNASTTSSAVSITVQSAGNNPPSGSITAPSYGATFTQGSNIAISASASDADGSVSKVEFFQNGNYLGEDTSSPYSYTWSNVSQGSYTLSIVITDNLGATTTPGSVSVTVQGSTGGDCNGIPQYTEGGGYNAGSEVQNVGSVYQCKEWPYSGWCNGGAQAYAPGTGTNWQDAWNLIGQCGGGTGGNDSPTVNITSPSNGSTFTPGSTINLTASASDPDGSVVKVEFFQNGNLLGEDTSSPYSYSWANVSAGSYTLTAKATDNEGASTTSTQVYISVTSGGNPSGDLPDRVLVGYWHNFDNGSGVVKLRDISDKWDVINIAFAEPTVQGGSSMSFVPDNSIYSTTQEFKNDVALLQSQGKKVLISIGGANGTIHLENATHAQNFSSTMTSIINEYGFDGLDIDLEGSSLSLGAGDNDFRFPTSPRVVNFINGMEAVLANFGSDFVLTAAPETAYVQGGYSTYGGIYGAYLPVLYALKDRMALIHVQHYNTGCMLGLDNQCYSQGTADFQVAMGEMLLRGFSVAGNPTSFPAFREDQVAIGLPASPSAAGGGYTNPNTVKTALDYLIKGISYGGNYTLVNGNGYSGFRGMMTWSINWDINYGYEFSNNYRAYLDALPAARWTPESPTQTPEVLEEVFITAPNPFSDWATITVTLNEAQETSLVIYNQVGQQIGTLHHGTLQKGTHTFEWDSRSANPGLYFARMVQGEQTQIIKLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E898</accession>
    <name>A0A654E898_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="13378" checksum="600588745FA97B70" modified="2020-04-22" version="1">MAKKIKIYLTYQKKELWWSTDKDNWGIVSAKSPQSVLGKNSQITWVAYDSSIDDITVDLDNDEIIDTPLIGDKKEKTGKVKSNANKGAQTKYTINVIPAGETAAISVDPDLKYCDPECPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8B0</accession>
    <name>A0A654E8B0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="34039" checksum="DF79CA070E59D0B0" modified="2020-04-22" version="1">MNSQTKKSTLKISAILLVGALAFTSCDKKEREQLKAQADQLEQKLHERDSAFNSIMNVMAEVETQIEQIKTQENLIANSSSGDFSSMEKDQMVGDLKKINELITSTNEKVKSLSSQLEDSNIELNAFKRRVQDMMKNLKAREASIAQLKEDIQMRDNRIAELDTEVGSLVTRVQLQTETIELQNQELVERENDLNTAFFAVDTEKKLKEEGLVTKEGGFLWIGKTTELQADAAQQKFTEVDIQNTKRFYIDSEKLEIVTEHPSESYKLVNEDGKVKYLEVVNPSEFWKISKYLVVSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8Q1</accession>
    <name>A0A654E8Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="362" mass="40455" checksum="CEFF75F62F76E544" modified="2020-04-22" version="1">MAASFKYNTDQLHSEAVDLLKQLISTQSISREEDKTADLIQGYFEEQEVPTERKGNNVWVKNQDFDDSKPTVLLNSHHDTVKPNAGYTRDPFYPSEEDGKLFGLGSNDAGGALVSLIMTFMYFYTQKDLKYNLILAATAEEEISGPGGIKSILRELGEISFGIVGEPTEMDMAIHEKGLMVLDCYARGVAGHAARDEGENAIYLAMKDIEWFRNYQFPKTSETLGPIKMSVTMISSGTQHNVVPDTCHFVVDVRTTDAYSNEETLELIRAQVNCEVQERSTRLQPSGITKDHEIVKAAEALDTKFFGSPTMSDQALMPFPTVKIGPGDSNRSHMPDEYIFVEEIKEGIMGYLMLLNKLFKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E974</accession>
    <name>A0A654E974_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ORF">MARINOS108_60014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="102" mass="11320" checksum="8BF8142F0BC39509" modified="2020-04-22" version="1">MIKALLLQVDAGGTNYTQFIMLAGMIAIFYFFFIRPQQKKQKDQKKFIEAVKKGDQVITVGGIHGKIVSVEDTTVTLDVDKGNKLTIEKSSISLDASKRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9D2</accession>
    <name>A0A654E9D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014555">
        <property type="entry name" value="RecF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029347">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="367" mass="42275" checksum="BFB3F6BDB8061434" modified="2020-04-22" version="1">MIDYLEIQGYKSIKDLKIELKPINILIGSNGAGKSNFVSFFKLLRAIFNQQLRRYVLEEGKADHLLYFGRKTTEHLFGKIIFKDGHYNNAYHFTLAQNRNGGLFLEEEAAGYNVHRDSLSSNYFKNYNLEESEAATANFPRNQYLRDYLKELQFFHFHDTSSKSSLRRECDVEDNLYLKHDGSNLPAYLYYLKIKHPVIYKRIAFTVRSVAPFFDSFILEPSRINDGKIELRWTEADDPDSNFGASQFSDGTIRFIALTTLLMQPEPPEVIIIDEPELGLHPMAISKLAGMIQSASSSTQLIISTQSVNLVDQFDAEDIITVDRSKEEKQSIFRRLQKEDLSVWLGDHTMGELWQRNIIGAGQPYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAB6</accession>
    <name>A0A654EAB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024932135" evidence="1">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="36489" checksum="0307634681EAD2AF" modified="2020-04-22" version="1">MKNYLKCLLLMLPFILASCEEDAEPQVVGQFDSGVFISNEGNFGEGDGSLSFISSAGVVSNNLFSTVNGGALGDVVQSLHVGADQLFAVVNNSNKVEAMTLDSLKSAYTITDVSLPRYMVSHDGVGYVSEWVSFSDLGRVTLFDLETGTVDKSITTDYGAEGLIITQGRLFVTNNFTTTVSVIDLSSEEVVASIQVGNSPAGMVLDADGDVWVVCSGGYDANYAPLNDGKLVELNPASYEVKSETDLNANLSGKIAVAPSGQTIYYLMGNQVYSLSTDAPEAGQVWKEEAAAVSFYGIGVDQSGNVYAADAKGFAENGEVFVYNPAGELQNKYTVGRGPNGFAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECY7</accession>
    <name>A0A654ECY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29142" checksum="55018B4607551CA1" modified="2020-04-22" version="1">MKLNYRKLGSGSPLFILHGVFGSSDNWQTLGKEFAEYYTVYLIDQRNHGNSPHSSEMSYEAMVSDLQKLMDNEGLNTIDILGHSMGGKTAMNFAVTFPERIEKLIVVDIAPIYYPPHHQQIFEGFHSIDLQRIESRKEADQQMAKKVKEFGVRQFILKNLTRNEENQFAWKINLQAIEQNIETLGSGLTEGQTFDKKTLFIGGSKSDYIQQKDHQTIQNHFPQARIRMVEGAGHWVHAEKPEELKTLVLAFLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFL4</accession>
    <name>A0A654EFL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="50" mass="5616" checksum="3922DCC9F7551117" modified="2020-04-22" version="1">MATYPSFSLLAPGRVGKENNLVLQPNGTNLAGRTQKIILTHRLWTFLKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSP6</accession>
    <name>A0A654DSP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="28576" checksum="B2C50191087D34E0" modified="2020-04-22" version="1">MNKIRALIIDDEELAREVIRTYLEKDETITLIGECANGFDGFKEINDQKPDLVFLDVMMPKLTGFEMLELLDEPPVVIFSTAHDEFAIRAFEQNAIDYLLKPYSYDRFADALTKAKSKLAMEVPSAKGLSEVVVQNKDHSGILSRVAVRTGSKIQIIPVGKIRYLEAMDDYVKLHTEQGVFLKQDTMKYYDEHLPAEDFIRIHRSYIVRIKEIARLELMGKDSHVVFLHDNTQLSVSRSGYALLKEALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTC1</accession>
    <name>A0A654DTC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025057983" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="58"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="303" mass="32820" checksum="7FFBA96774FE0D37" modified="2020-04-22" version="1">MKRTTTLICCLIISFASFAQSTLAEHHFESSDVKKVVIDGAFCDVFVTPGSSLVFDGIIKGSGKSGDYLIASIQTGSTVVFRVERKQERNRGWSNIELGKLALTLPEHIELKITNTSGDINVSDFTGELEASTTSGDIVLKNINSDCWLKATSGDLRARNVTGDIKMRSTSGDQEYFEIRGNLETQATSGNIECDKIKGNVKAFATSGDLDFDGIEGAIEAGTTSGNITGDYVRITGDSRFKSTSGDIYFVFENEIESLGFDLRATSGDLCVGSSRSEDRLYMDRGQYTIAGESTSGDQVYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTM0</accession>
    <name>A0A654DTM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="80" mass="8586" checksum="1130A83438185A18" modified="2020-04-22" version="1">MLANKGFPLPSRTCTRSMCISSTSPAFRACCRILAELMQTAFEPALALAWLMASSTPVVMNVKGESAFVHSATGWCVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTP2</accession>
    <name>A0A654DTP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="475" mass="55285" checksum="C73C4E54525E9901" modified="2020-04-22" version="1">MSTSELMTLYQSTKGRVVIENKILDDHVDHFFEQIDTLRKFTAFVNCQINQLSTDSIRTVDSLLFVGCEIGYIDTGGSYFGGYLEISGNSLHSLNLYDSEFRSSVHINNRELTMVSFRRNILRNIATQIVLESEKNSDLFRKPTPFRNQFFLGSNAPIGEVILSNNTFESEDLFQTVQISAEMGKLMIQDNTFQSTLDFDRATITNQLMLFQNSINRISFGYMTFSETYNLIEWDDLKGFRILQTTKRDVEQFKLTDEDQILLKNQSNYQVPRAFYEAQSKLELDYLPLYDDLIRNYYSLYLSSKQFGNIRYANGINYEMKEIEGRWLRNQYLNQRTFSNYFKWKLNRLMGFYTRHGTDPAKSVMISLLIILIFGVFYFFFPSDWDKESKASMILKFKELIARDGVYVKPFFVLSWAILLSLINGLTLSLNSFITLGFGQIPTHGLAKYACIIEGFLGWFLLTLFVVTLINQIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU10</accession>
    <name>A0A654DU10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="13375" checksum="1899BC7D7ACEA4CE" modified="2020-04-22" version="1">MSSNIRVPKICQHCGNEFIAKTTVTQFCGDLCAKRAYKKRQREKKVQEIPSVASQKSQHNQQKLQDKDFLSISETCELLGASRMTLYRQIKSGTINAAKIGRRTIIKRTEIEKLFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU26</accession>
    <name>A0A654DU26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="40233" checksum="AEEA74ABA0593D0F" modified="2020-04-22" version="1">MSTELDIYNRILFLDLRPWMISNVSEMKFKQDLNDLEKTYYQVQPSFELSFLNPLSNKRKYYTSLIDHEAIRFLNNLHKAVEEAVNDNEKKYHVHWALTRTLPQKLKELAQVLIERQYQEEQYQPKTGLSSQDKVLADESFIIHYLKHELVRLYMEIQEAYPSLLKQDPLTEEEIYYTYFEQTAPQPSVIVEATKKPLAKAAPIKPDSVETSTFQPISNDVRPEKKGILTFSTIIKNPNRFGSFESKLHEYGYIDADYNFTNKHGAKNELACIYLHLINKGYFNKRQFPGNKEIKDVAIRKFLDHRYATDIDKQFRTYRNDPDAVADYVDTQFWLTQLPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU47</accession>
    <name>A0A654DU47_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MARINOS108_10149</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024792579" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="20"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="323"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="14">
        <location>
            <begin position="580"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD10646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="648" mass="73514" checksum="C49758DCEECD9098" modified="2020-04-22" version="1">MRTLLVSLVLCVLSTVAYSQTEIAHCNRSSGMDVEASDPVSDHFDMKYLWLDLAADNLSTSISGSSTLLVEIIQEEPNEFILELIDELDVLKVTVDGKEVNFTHHQDLLYISRPASVHTGDLVSISVTYEGTPNPASAGIFSGINNAQSKAWGNQITWTLSEPFNAKTWWPAKQDLNDKIDSVSVHITVPNHLKVGSNGTLTRSLSLIDGKTRHEWKSTYPMAYYLVAFTVGEYVEYNNYAKPTALSGDSIFIQNYLYNNPETLPYYKDELDMIPEMMELFSELFGLYPFHQEKYGHVMAPFSGGMEHQTMSSMGIFTFGLDAHELGHQWFGDHVTCVTWNDIWINEGFARYCEYIAAEKLLSVKNARAIMEDDMLSVTGTDTGSVYIPLDEKLTDSRIFQYRLTYLKGGLLINMIRELVDDDALFFRTLRIYLQEYGGRSASGEDFRAVLERETKMDFGSFFQQWYYGGGFPVFDITWTKLAGDTLGISIHQSTTDDVPFFSTPLEFQITFKSGQVKRLLLRPEENTQFFKVPASGQVKTLTFDPDKWLIKKVNSFHQVDENGNIILSASYQSPEELIVFPNPATTEIHLNRKINSIKIYDTTGRSILLIQLNHQVQTIDISELNPGLYFFQATDDSQLWNGKFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUF0</accession>
    <name>A0A654DUF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="617"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="792"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2661" mass="281116" checksum="4306DA53E84B3CEB" modified="2020-04-22" version="1">MKTATLRVFITNTLILLCFTLYAQSPGNVSSNLKLWLKADAGVTGTSPVTAWGDQSSSSLDATASGSPALVTDGLNFNPTIAFDGSADKFITASTSLFSSGSSPASFFIVFDTDNGSSQRFLVNQRYNNNCNTNIQLGYTAGGSSRNYGLHIGCGHASGAPTGTIQDNTFYLMSTLLLSSGNAPTNINIFQNGASLTVSNNSNGFTDAGSYDTQSVPIDIGVRNDAFGGSSFDGYHDGDIAEIIVYTSTPTATERQQIESYLAIKYGLTLDQTSPTNYLASDGGTIWDGTANAAYNTDLAGIGRDDNSALDQPKSKSVNSNAILTIANGGIYSPSTLGTDDSWLVWGSDNGSLTFSETVDNVTSGTSSRMARVWRVQETGTVGEVEVAFPVAHASGTISMLIHPSDPAFPNDANRDIFEMENDGTYYRVTVDLSSGDYFSFAEGSVDTSPAVLINEIVATPRQDWSVGSFYNPTPGGANGSDDEWIELYIAEDGLDLTGWTIEFDDGVEVIGDLTSSGAFTISNYLSLQGGSFKNTKNGDFLILGNPIGSELINATGTSRFYLRDASGKIIDQVTTSTTEGTFFNANSTGTTDESISRIPNGGDTNIDQDDFSKTRATLGTTNSPSGMVKINEVATDPQQDWSSIGFNGTAPGGTGADNDEYIELYIASAGLNLTRWTLEMKDGSDVSGTLSTTGDGVFATVNYITAGSGSFIDTEVGDYLILGNPIGAMNNDVLIILKDATGTAVDSVQLGGATGEAPTGNAVSVNDEAVSRYANAVDTGDDDLDFVRTIASPGSTNSPTGTVLINEIVTDPQQDWSTNGFDGTIAGGLVSDVDQWIELYIGTTGINLTGWTIELTDGTDVIGDLTSSGAFDVSNYISNSVGSSFLNTAEGDYLILGNVDGTGATNDDILITLKDAAGNIVDQVELGDDAAGDGTGDGAPDGSSVGGYATDLSNESISRLPNGTDTGNDVADFQAISATLGRANSTSPIPVIGNGLLFDGIEDYVLIANDADLDFNQSGFTVEFWGFITNTSAFPLAKGTGGTGNEYFFEVDATGKIRFGVTRDNDTQYTSGWSTTDIRNEWYHIVGIFNGGSIDLHINGVMENSTSWAGSMKTGQGDFFIGKQATGDFVAGKIDEVRIWNDVRAQSELCQNMNKTINGNETNLVAYYRFDQGSGLTLPDITVNNNDGTLNNMTSADWVVAEWNAFSDMGLILDGGGSDISPGTSANLTITDVDFLQNFNDYLIFGHENSDFSEVTSDLPSGTLVSARYDRNWHIAKSDVVGTAGGDVTLSFDLGATPNSDYTYYLLERAGTSGDFSIVPVDGTNPSGTSIVFTINASQINDDSYYTIGRSDTGVGNALDFDGVDDHVVTPITRESLSNYTTEAWFRFDGTITDGYTPIFASVGTNFFLGKNTGNSDIGIEDGGFVGNVAVGTSAWDGQWHHIAMTSSSGTNQIYLDGVPVGSASSFTGGSGAVWIGREPEGGGYFFNGLIDEVKIWSDVRTQTEIVSNMFSNIAGDDANLIAYYRMNDGIGDGNASLPDLSGNGNSGTLTNFDNLNAVTASSNYLTSTRTTFENASLIVNGGALTASSDELTLTSTQTAGDFLQDAGDQIIWGNDNGNFSEVATDLPSGTLLSNRIDKTWYLDKNDAVGTANGNLTFSFDLGAAPDSDYTYHLLTRAGTSGDFSIVEIIGSVPNANSIEFTVDGAQVVDGNYFTLGRSDSGAGNALDFDGTDDYVDLDNLGLTSGTIEMWIYANDVIDNRRIYSQLTGATSQAGSIGIDPNNTDDFGIFTWTGAAWLELVDVGSDWSGAWHHFAVVYSGGVATAYWDGVPQLTQTTNLDFSGVSMGVGAQYTGGNGTTFNGKIDELRIWDDARSQSEIQQNMYRALDVANESNLVAYYKFDQGIADGTNTGVDLLTDHSGNDNSGDLTNFALSSTASNWVGSTATVVDAASAPALVGPGNALDFDGTDDYVMVSSPYTGFTNALSVEFWVNATAMPPGSILGQSTSDVNAAATNVFLIGNDGSGGDITFYVADGSGFPGVVTTTTNFLGTGWHHVACVSDGAATKIYVDGILEGTGGGVPSINSNLSAALHIGKDSRYSTTRFFDGIIDEVRIWNTARTSMQIQENMFEELTGSETGLVAYYRFDEATGSTTLPDESTNSNTGTLTSMDAATDWVTAAAREPFKTLNGGNWNNTSTWKSGAVPNASTAVLNIKHDITLDASVSADMININDGVTLTLASGQTLSISGDIIDNGTITGDGSILLSSGTPMLGGTFGNLTVNGASPTLTANTTLSGTLTLTSGNITLGDYNLTINSGGSIAGGSSSSYVQTLNQNTGGGALQLEVANGAGPVIFPVGTSTYTPFTMVNLGATADFQVRVFDGTFSRGTYGTAHVTDLEINRTWDINSDDSGYNTTITIQWNASEEDASFNRADMFISKNRSDGYWRIIADNLSAAGANPYTASASGVTSFSQIGGGSDGSPLPVSLVHFSGQVLENDVLIQWKTATESKNDYFILERASSSQEFEPIHKVEGAGDSDLLLEYDFMDRNPFAGHNYYRLKQVDFDGAHEYSSTILINNESLPKSWSVYPNPFVDDITFIFGGDLEGEAELIFYNLAGKKINSYHFNMVNGRLNINHLQLPDGVYTMKLIHNGQEFTQKVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUT4</accession>
    <name>A0A654DUT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Agmatine deiminase</fullName>
            <ecNumber evidence="3">3.5.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aguA</name>
        <name evidence="3" type="ORF">MARINOS108_10414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.3.12" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024877420" evidence="2">
        <location>
            <begin position="20"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="429" mass="48261" checksum="A4E859A1936A3520" modified="2020-04-22" version="1">MRITLFITALLLLSCATHSNQPDSWTVTRQPAEYEAVDAVWLIWPPREHKNDESVQKVTLAVIEALIDDLNVIVTCGDKALCDEARKVLNSRFKESQNLTIQEIPSVEIWTRDMGPTFVETSDGRHAIADFNFNAWGYTDTLDTDTQTEELYDTRVANLLQLPVISSSMISEGGNREVNGLGTLMVTESVEQGRNPHLSKSQMEAEYSRLLGVEKVIWLKRGLQEDDHTFLGPLNTADGTKAYTVVTTNGHIDEFARFVNDSTILLAQVDSSEFDDPIAMENHRRLEENYQLLLQETDQDGNPFNIVRMPLPATVFDEMAPGDYVYDYIKTLDYRDGSIFPEGDTIAVVAAASYLNFLITNTVVIGQKYWREGMTDEIKRKDEQAKGVLESLFPDRKVVMLDARAVNLGGGGIHCFSMQQPRLKPKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY5</accession>
    <name>A0A654DUY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="121" mass="13558" checksum="71889266091D0948" modified="2020-04-22" version="1">MNDKNQILAEHFERLKELIPEVYSQKMMSAGGDENTQLFQLLKRSLGIVEAIYLQGGSPFNPATVEEYAQVIKEVKSMGYNYNGNEGLLEKATGQLIMKAKKPMEKAKGKKKESGSDRKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY7</accession>
    <name>A0A654DVY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="17700" checksum="9768AEA8B639982D" modified="2020-04-22" version="1">MEFFILSFIILSIAYMAWRRWSGAPTPPAIKVSEEDLLIKEESFNRINKWIISEKKYLNPDIKLDTVAKGVHLSEKQVSSSINTIACQNFNSYINKLRIKEAQALLLDQAYGHFTIDAVAEMVGFSNKVSFYKAFKKVTGKSPTDYRRSPNQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ7</accession>
    <name>A0A654DVZ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">leuS</name>
        <name evidence="14" type="ORF">MARINOS108_10893</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="278"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="775"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="697"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="924" mass="105834" checksum="C6E5DCD32300A429" modified="2020-04-22" version="1">MAEYKHLEVEKKWQQYWQENKIYEVSIDPSRPKYYILDMFPYPSGAGLHVGHPLGYIATDIISRFKRLKGHNVLHPMGFDAFGLPAEQYAIQTGQHPAITTETNITRYKEQLTNLGFSYDWSREVRTSEPSYYKWTQWIFKQLFNSWYNKDSDKAEHIDTLISAFAESGNQSINAVCDDDVPAFSSSDWNSWSEEAQQKMLLKYRLTYIAETTVNWCPALGTVLSNDEVKDGFSERGGHPVVKKSMAQWSMRITAYADRLISGLDKIDWPEPIKDMQRNWIGKSYGAEVDFAIENSDKKIRVFTTRIDTIYGVSFMVVAPEAEIVQHLTTPEQKQEVEDYIAVAKNRSERERMSDVKTVSGVFTGSYVIHPFSGEKVPVWIADYVLAGYGTGAVMAVPSGDQRDFDFAKHFDLPIVQIIDSQKITETEADATKEGKMINSGILNGLTPLEAIDKAIAEVEKKGIGVRKVNYRLRDAIFGRQRYWGEPIPVHFKNGIPYLLEDSELPLNLPEVDKYLPTEDGAPPLGRADNWQYKDGTPYELTTMPGWAGSSWYFFRYMDPDNDQEFASEKALDYWQQVDFYMGGSEHATGHLLYSRFWTKFLYDMGFIKVDEYAKKLVNQGMIQGRSNFVYRVKNENKYVSFGLRKEFDTYPVHVDVNIVKDDILDLEAFKSFRPDAEDAEFVLENGKYVCGWEVEKMSKSKYNVVNPDDLVEKYGADTLRMYEMFLGPIEQSKPWNTNGIEGVYKFLRKFWTLFHNNREDLLVVSEEPATKEELKVLHGLLKKIEEDIERLSLNTSVSNFMIAVNELGALSCNKRAILEPMVIALAPFAPHLSEELWSLLGHEESIFNASFPVFDPTHLVEDSFEYPIMVNGKMRAKIQLGADLSKEEIESQALAHPNVQKWTEGKAPKKVIVVPKKIVNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW23</accession>
    <name>A0A654DW23_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25670" checksum="7B326FEFE0DD13D8" modified="2020-04-22" version="1">MGDIAVNINKIKTELAGTSARLIAVSKTKPMSAVQEAYDSDQRDFGENKVQEMTEKYEALPKDIRWHMIGHLQRNKVKYIAPYVHLIHAVDSVRLLREIDKEAAKNDRIISCLLQIHIAEETTKFGFDKNDLQYFLENGELEALTHIKVCGLMGMATLTQDTTQISKEFEGLKMLFDEFSSKFHFRNFELTELSMGMSGDYRHALEHGSTMIRVGSSIFGERNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW73</accession>
    <name>A0A654DW73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LVIVD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025020653" evidence="1">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="251" mass="27362" checksum="D8288D7D9BFDCDCB" modified="2020-04-22" version="1">MLQAMRKLLLLLVVSFCWSCTDESGDVGFIDGGGVGVGGSTARFAINGEFLYIVSNTDLKVINISSVADPQYQSSTPIGSGIETIFGFKGNLFIGGQSGMKIYTVDALGRPTYRSEFVHRTACDPVIANDQYAYVTTRSGEGCNNTLFEANRLVTLDVSNLDNPFDVDQQQMINPRGLAFFKGDLFVAEGASGLKQFSLEDPAHPVLIHFHTEIAANDMIALENTMIITRDDGIYQFGCVDEDLELFSPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE3</accession>
    <name>A0A654DWE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046235">
        <property type="entry name" value="DUF6268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19783">
        <property type="entry name" value="DUF6268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6268" evidence="1">
        <location>
            <begin position="95"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="307" mass="34566" checksum="F8C33E97950DBD51" modified="2020-04-22" version="1">MNLMTHSYRTLLNILCGMLLLISTPLMSQDFQLAGFSVTRFPTAEVMNAPLNQEVKVNEYDFFLNLPKQSENEKTVLINGFQYRLVTPVVENDFNPGMDGENLHLLGYRLTVLHQLSNEWKVLISLNPTLSSAFDTTLEGDDFLMNGALLFIKEKSDRFSYGGGMAYLSSFGEPRFIPTLQVTLTSEKGKLHVLLPRRITYDYYFGKFTAGLKAEASGSRYNVNYRRTTAINDTELVDMLVYSRVVLGPSLNYRVGKSIQLEASGGIAVARRMELQGDQIKDANYDTANASFFRFGISLVPPEKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE8</accession>
    <name>A0A654DWE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="20743" checksum="3AE27636CDF24488" modified="2020-04-22" version="1">MDPYKTIWFAPKRTFENFFQSESKQPVYFLPFLIFGASFAIEQSYAIGNLFGDGALIWTALIMIPVGIGVIYLVFGLLLPGLTHWIGSIWKGDSTPRQMTNVYSISIIPYCILLIYQLALFATGTEPTIENMNGLTQYIIRLWTFALLIIGIARVQRFNYGLALLNLLLTYLPFLLIALMIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWI4</accession>
    <name>A0A654DWI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="431" mass="49494" checksum="9D54CB917C98916D" modified="2020-04-22" version="1">MRNQPFWHIAIFCVLAIMLFGCNSLRKLATSRDIDAYLKHSEIFRNEFSGFVLYDPLSGKYLKTKNADLHFTPASNTKILTTYACLTSLPDSIPSFLVQQMADTIRLEPMGDPTFLHTDFPNQPVINRLKNKPIEIHLPDNKLTPFGPGWAWDDYQYSYQTERSWMPIYGNEVRIFNRDTLSVVPAFFEDYISLFVGEKPGSLVYRERKFNLFNIWMEYDTSSFERKIPFDYSDELLARLLSDTTNAPVSFSKAPLSNYTTLYNEALVPALTLMMQRSDNFLAEQLLITAARYSGYNNPDAFRNHLLSKWHLSSPIQWVDGSGLSRYNLFTPRALVEILALIYGQLSWNEITMIFPTGGVSGTLKNWYPGNPPYVFAKTGTLSNNHCLSGYIKTNSGRILIFSFMNNNYLSPVSDVKREMQRVLEAVRDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWP1</accession>
    <name>A0A654DWP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045470">
        <property type="entry name" value="DUF6495"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20105">
        <property type="entry name" value="DUF6495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18431" checksum="D2E072D4697DA002" modified="2020-04-22" version="1">MPVNPKYRALTKDELAGLEKEFVDYLIVNGITADDWVKIKEEEKEKAEDIIVLFSDVVFEGVMRKVKFLEFREKSDLKSFQCLEEKIILVGMMSENPEVNFTEKKYLKTAAQEPPKGVKVYSTEKRYAKTRELELFEMIQAGCSISDGQIFKALAMAMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV3</accession>
    <name>A0A654DWV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="4">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioF</name>
        <name evidence="4" type="ORF">MARINOS108_11403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="44"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="43689" checksum="02C6A930E72D7A6C" modified="2020-04-22" version="1">MSSILKNRYQSYQEPQKVKALNLYPFFRNIQSGQDAEVMVEGKKVLMFGSNSYLGLTTHPKIKEAAIAAIKKYGSSLSGSRYMNGTSDMHTELEGRLAKFLNKEAVALYSTGFQVNIGVLPTIAGKNDYLFLDRLNHASIFEGAKLSPAQSVIFRHNNMESLEQKLSKVPIDAFKFIVVDGIFSMEGNIVKLPEIVKLAKKYNAAVMTDCAHAIGVIGENGAGTSNHFGLTDDVDIIGGTLSKSFAALGGFCASDADTINYLKHHSKSMIFAASITPPSIASALAALDIMETDDSHRLKLWDNTHYTLKVMKELGFDTGASETPIVPIFVRDDLKAYKLTRMLFDRGVFVNPVVSPGVSPEDSLIRFSIMSTHTHEQIDRAAEILFQAAKEVDLFQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV7</accession>
    <name>A0A654DWV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024996025" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="115"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="438"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1066" mass="115539" checksum="DE695C05DF4CEB70" modified="2020-04-22" version="1">MRKLLLIACLIMLQGLLYAQERTISGQVVDDNGESLPGVNVVLKGSTQGTITDLDGNYKVPLNGDDDAILVFSFIGMQTKEMAIGGRSVLDVTLSQDVTQLTEVVVTAFGVEREKKALGYSVQDVKSDELTKTDQTSVLNSLQGKVAGAQISNAGGAIGSSTRIVLRGPTSLLGNNQALIVVDGVPINNGTSNNVQASGNFYDNIVDAGNRANDINPENIESVSVLKGPAAAALYGSRAANGVVLITTKKGTNTAGKTNINFNSSYTWSKVYIIPKMQNKFGQGQFGDNQNYLFDQESWGDAFDGSLRPYGAVVNNIQRYKPYEALPSNVQDFWETGNTFQNSLSLSGGNADATYFLSFNDMQQNGVMINTDMRRNNLTFNGSANLGDKVTTSASINYVRTKANLPMIGQRNQALAQVYNMPRDMSVVDMKDLDDPFNTPDGFFTSFIVNPYYSLKRDFSKQDMNRIFGNVQLAYAPVDWISGTLRVGSDVIADQRNTYHDLVQYQPGSPNAGAAFNSDGEYTEQRLNTREINVDAMVNVNRDLMPDLQLNVLVGYNFNQRETDNLFTTIDALTLPRFPSLSNVSGSYTSGGIATKRRLYGVYGSADLSYKGYLFLGATYRTDWSSTLPLDNNSFSYPSVNLGFVFTDAFEITNNILSFGKVRLSYAEVGNDAGTYLTNSVFQQTNIGASFATIQFPFNNGTVIVPGFSEGNTIGNPNLQPEITKAYEAGIDIRLFNGRVGIDATYYNSTSESQILNTSVAPSSGFTTQVVNIGKISNKGVELQLNTTPLKIGAFRWDLSVNYTKNVNRVEELDPGNTELVLVAQGLTPGLKLVVGKPYGVFEATQALKTADGKVVVGPDGIPLDDPNPVEIGSIQPDWYGGATSTFSYKGLSLGITVDTKQGGKVVSSTAAQLYFAGLAEETAFNSREEWIVPNSVVQTGTDDDGNPIYSPNTTPLTMYGGGNVRNYWAQIQGGSRNEAVLLDASYIKLREVALRYTIPTALISKTPFKGITVGAVGRNLWLRTQGNNHFIDPEASAFGNGNAQGYEFLGIPPQATYGFDLKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA0</accession>
    <name>A0A654DXA0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitate hydratase A</fullName>
            <ecNumber evidence="4">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MARINOS108_11543</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="15">
        <location>
            <begin position="558"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD13578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="755" mass="81219" checksum="661A377E8A95252C" modified="2020-04-22" version="1">MAFDIEMIKKVYASIGERVNKAKEVTGKPLTLAEKILYSHLYEGNPSESFKRGESYVDFAPDRIACQDATAQMALLQFMQAGKSKVAVPTTVHCDHLIQAKIGAASDLQSALNSSNEVFNFLESVSNKYGIGFWKPGAGIIHQVVLENYAFPGGMMIGTDSHTVNAGGLGMVAVGVGGADAVDVMAGMAWELKFPKLIGVKLTGKLNGWASPKDVILKVAGILTVKGGTGAIVEYFGDGAKSMSCTGKGTICNMGAEIGATTSTFGYDESMERYLRATGRSEVADLANGVKEHLTGDDEVYANPEQYFDQVIEINLSELEPHVNGPFTPDLATPISEMAAKAAKNDWPTKVEWGLIGSCTNSSYEDISRAASIAEQALAKGLKPAAEFGINPGSEQVRFTVERDGFLNTFEKLGTKIFTNACGPCIGQWDRAGADKKEKNTIVHSFNRNFSKRADGNPNTHAFVTSPEMVAAIAISGNLGFNPITDTLTNDKGEQVKLDPPTGWELPEKGFDVEDPGYLAPAEDGSGVQIKVNPDSKRLQLLEPFAPWDGKNITGAKLLIKAKGKCTTDHISMAGPWLRFRGHLDNIANNTLTGAVNAFNDETDKVKSQLDGTYAGVPDTQRAYKAAGVPTIVVGDHNYGEGSSREHAAMQPRHLGVKAVLVKSFARIHETNLKKQGMLALTFANEADYDRIQEADTFDFVDLTEFAPGKQLTIVAKHEDGSSDTIKVNHTYNAGQIGWFKAGSALNLIKLQNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC3</accession>
    <name>A0A654DXC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="72"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="565" mass="62180" checksum="D81FE9C0D2E3E5E3" modified="2020-04-22" version="1">MRKLSVITLLMAFIIGGCQKPQTKADLVLLNSKVYTLNPDAGEAEAIAVKDGVILFVGSNDQVRDLVGDSTEVLDMSESYIYPGFIEGHAHIMGIGANIINVDLMQARSYEEVVRMVQERAAVTPAGEWIIGRGWHQDKWDEVPELMFNGFPTHHSLSEAVPDHPVLLSHASGHASLANAAAMNLAGVNKSTPDPEGGEIFRDVSGQPTGIFNEMAEKLIVEKLPLKSAEYKSDLLERAIQECLSNGLTGFHQAGSDQADVALFEQFASENRLKLRLHVMLSGADTALLKTYFASGPRSGLYDQHLNIRSVKLYADGALGSRGAWLLEEYSDARGVHGHNVTPMDQIEDVVMRAAASGFQVCTHAIGDRGNREVLNIYEKALERYPEIAQDHRFRIEHAQHIHPDDIPRFARLGVIPAMQAIHMSSDRPWAIDRLGRERIENGAYMWSELIDNGSVIVNGTDAPVEPVSPLASFYASVSRKTLKGTPEGGYEPAQKMTREEALKSYTLWPAYGAFMEQSVGSVEVGKLADFTILDRDIMTIPEDEILNTKVKMTIIGGEVLYADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU8</accession>
    <name>A0A654DXU8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032858">
        <property type="entry name" value="CcoP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038414">
        <property type="entry name" value="CcoP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14715">
        <property type="entry name" value="FixP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024791301" description="Cytochrome c domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="8">
        <location>
            <begin position="184"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD14341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="32391" checksum="88CD43F0C65C3C33" modified="2020-04-22" version="1">MNYSKSVLILLSILGGPVMVQAQDTASDFYTLYQVEIVLTVGALVVVVALLALYTSLYALSAIMGAKHQSAPVVPAEGFWSRIWHRLNNAVPLEEEATVMTDHSYDGIRELDNKLPPWWLYGFYLTIIISVAYILHFHVLGTGALQDEEYYTEMELANAEVEMYLASLDNLIDESSVTMLNASEDLAVGQDLFVSKCAACHGQLGEGGVGPNLADQYWIHGGDVQSIFKTIKYGVPSKGMISWQAQLSPKEMQQISSYVYTLEGTNPPNAKAPQGELFEREASVPLDSVKVATAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV2</accession>
    <name>A0A654DXV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="107" mass="11958" checksum="5C1567B3C360B55B" modified="2020-04-22" version="1">MKGYLGEFEELVLLTIANLGSDAYGLALIRDINERAGRNLSMGGMHSTLTRLEEKGYITSHLGEPTRERGGRRKRYFELTNSGIASLNDMKALRDELWANAKVNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW6</accession>
    <name>A0A654DXW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024882583" evidence="1">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="307" mass="34962" checksum="F9540A19BF7CE788" modified="2020-04-22" version="1">MKQALALLLAALGFFQVAAQKQVAITYDDLVLNGPYISLEHTIAVNRQIIADCATFGVPAVGFVNEKKLDVTGETVTRINILKSWLDAGLELGNHTYSHPSLSRTPLEEYQNDVIKGEEVTKALMEERGQTLRYFRHPYLHTGPDSTTKASFEAFLSARAYEIAPVTVDGSDYIFNTAYVDALRAGDTSLMQRTGAAYVAHTLRMFDFMEEVAKEVIGRNIAHVYLCHANAINADYMGILYQELKQRGYEFTSLKEVLQDEAYQRKDYYLGKWGISWLYRWDKEKSTEWLKIEPEIDQEILSLYNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY60</accession>
    <name>A0A654DY60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024795427" evidence="1">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="175"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="512" mass="57983" checksum="26350AF79B65E367" modified="2020-04-22" version="1">MKNLVYMFLSLLSLTATAQKVVELPMASTKIVVKISFENGSMSDPVGKEGLTNLTATVLTETGSDQYTKSEIDDLLYPMAAQYRAFTDKEMTTFTFEVHKDFLNEFYTIFRSLLLNPSFAERDFSRVKSNTEVYVKEVIKASSDEDFSKMALEARLFAGTRYAHMKRGSINGLANITREDVVNHYKAFFTRNNVTIGIAGDYPASFLETLKADINSLPDTQPTVPELGEVAMPDGIQVQLVTKPDNLGTAIFTGYPISINRASADWPAMLVVNSYLGEHRKSYSKLYQLIRETRSMNYGDYTYIEWYEAGGSNQLPLTGFPRSQNYLAIWIRPVQTAYSLKSQYPELGDIKIGHAHFAMRMALNEIDRVKNEGLTADEFELTRQFLRSYMKLYIQSPERQLGFLMDSQFYGMENYIAEMDAKLAKLTLEEVNAAAAKYLQTENMYITMITDSNEAEPLKKSLMTNAPSPMSYSNIIRESLPERVFEADKKVEAYPMNVKKVTIESPASLFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY65</accession>
    <name>A0A654DY65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Bacillolysin</fullName>
            <ecNumber evidence="11">3.4.24.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_10521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.28" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024973824" evidence="9">
        <location>
            <begin position="27"/>
            <end position="3935"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="3263"/>
            <end position="3361"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="3360"/>
            <end position="3457"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="3456"/>
            <end position="3556"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="3555"/>
            <end position="3653"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="3652"/>
            <end position="3755"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="3754"/>
            <end position="3869"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="3935" mass="425344" checksum="E2F277F5B266A4EB" modified="2020-04-22" version="1">MNLCSAAHIRFTASFLLLFVATLSHSQRLPEGGNASRKIPKAKEVLLDKAGSPRFIRFEKSLKMDSLPALGMLLGLPEKSTLRLKAKIANHKGEEHFRYVQEYKGLEVLGADYIVHAKGETAVSANGSIERKIVVNTLPTLSGEAALQLALDEVGAEVYMWQDEENERFLKRESKNARASFLPESKLALSRKRYDKAEALNLVYQFDIYAQKPLGRYNVEIDAHTGEVINFYNKIHTATTTGTGLSLYNGVVPIIMDFDGANYFLSDDSTGGGIYTYDLKHGTSYGSATLFSESDNYFDQSNSRAGVSAHYGAAATYAYFLENFGRNSYDDDGAAIRSYVHYSNGYFNAFWDGSRMTYGDGNASASALVSLDIVGHEISHAVTEYSAGLVYSYESGALNESFSDIFGQSIEFTTFPETASWNLGDEIYYDGVSMIRSMSNPNAEGQPDTYHGDLWYYGSGDNGGVHYNSGVQNFWYYLLVEGGTGTNDNGYSYQVNGIGLEAAQQIAYRNLTVYLTSTSDYADARIGSEQAALDLYGAGSDEYAAVVAAWNAVGVASSEPLMIVTDSVVFGQVPVGITETIEVVVANQGSGLLVVSDINVDNDVFAVSDTSFSLGELSSKTITFSFAPTETLDTSATFTLYSNIDTVSIFASGSGAEPPTLVISPDSIADSLYTGGVSETILAIHNSGFSDLEYELSTGLVDDFLGEWLVTYDWFCDGGVSGVVMNFFEDHTFTTSEGANGLWSMDGDSIVWVFESSTRYAGLREGDFMSGLMTSGMYDGCWYADKVTDFNTPIVLAASEWSVEGGQVAAPERTVDPKEGVASAGNSNWLYTSVSEGVVAMGDTAYVAITLDAGGLYGGVYETNLMLMTNDPERQLEEIPVSLFVTGAPDVALSHDTLFFEDAFVNFSDSLNLFISNVGTDDLELDLYFEHEYFSTDSTHLSISPSAGFNLPVYFQPDSVGSFSSALLFVTNDFDQDSIYVYLTGWGINPPVFGVSPDSLGAALFTGDSTTLVLTLDNLEGGSDLTWESEWIVELEATELYKAHEHMAHLVPSDGSGNNEGMATAGPIPMESMQALSGNKRILAWTTFVDMDQEYINTINAISQYYSDYQLSTTITTSAAELGNMLDTVDVFLIPEQEDGGSLSYFYDLGVSWSEVIRSFVKGGGTIILCGDHESGEILNASGLMHMAYAANAYGNALTLEDSTHYLTAGVTGHVTGQNATFVVSLSDTLASNLISYSDYAAVAHRRIGRGDVVYIGYDYYAYNDNAARVISNAVAGARGQRAWLTMETESGTIGAGESQDIPVKLNATDLYGGVYRAGITVQSNDPAKQNRTIPVHMEVTGVPVIKVINDSLQFESVYAGYEKELSVTILNQGTDILTVDVAFSDSTFITDTLHVSVGPGEAYDLQVFFQPDTAKSYVQSLWLISNDPNQDSTLVSLSGIGVNPPVMNVSPDSLHEALYTGDSATQILTIDNTVGGSDLIWKAEIHFELEETELFKANQHLIQMSPSDGSGNNQGMSKSGPISMETMSALSGQVNILSWVTYADMDQEYLHTLNAISQYFTDYRLSSTTITSATVLAGMLDTVDVFLIPEQEYASNSYFENLGASWAEVLTAFAERGGAIILCGNPSAYNIIDGSGLMHMEYFMPVYSEVLTVEDSMHYLTEGISGAVLSQDGTFLMSLADSAASNIVSYYDHSVVAHKNVGRGDVVYIGYDFFNYDDNAARMIANAVASANRSSWLSLGVAMDTIAGGELQEVPLTFSAKDLFGGQYRANINILSNDPASSELSIPVVMEVTGAPVLSINSDSLPFADTYVGYSDKVSILISNEGTDDLEISLSLLDSVFAIDTAYLLLAPEASYELAVYFNPDSAGVFEGGLLLATNDLDRDSTFVSLTGTGVNPPVMTVSPDSISAALMTDETVIKTLTVDNTAGGSELVVQFESRIHAQTITKPLTQSRAPSSTHDPTSLSQDFGSYLSDTARVLIIQNSSAWGMDMRSFMQETFGITAMTIYPQVLSGHDLEPYDLIITTGDQNYEYYETISNNRERFEDYVENGGVIQYQLATQGSNVSLVGGVNIIHGSADNRNTLDAPDHPIGKDLPLVLEGNSANHTYLTDLPEGATVITSTEYSTRPTTAEYSYGSGHVIVTGMTVEYLALSGFNSAPLLGNITSYTLSLSGQKWLKVPEADTIPAGEYRDFEVLLNAKGLYGGLYSGEIDVLSNDPASPVVSVPVGLFVTGIPDMEVDQDTVDFGKTFVGTSNSRPLQIENEGTDTLYVSDVVFDHLSFAVDTTSFYLLPKQTQTLEIIYSPEVVADDTVQMSISSNDPDEVPYIVYLLGQAVHPPIAGVDQDSLSESLLTGLQSTQTLTLENTGGSELEWSLEINNGGAVALTPVGFYGAPSPQVDVPELSSEAGGSHFGSIEGEVLDTLANFTSSSTGIYVKGDTIYTVNYNQARLDKYSLSARQVVESFPLHSSPYGITYAAGLLWIGSYDGLVRAYDSGGSFAGSFSVPFSNYPAIAFNGTHFILTQAIEYNEPFYVVDFDGTILNTYVGINAEVTELAWSNGTVWTLTFNGESNIYPLTISDGAMHINDTIRIPNDDFAYSLAHDEGKLYWNAWNSDALVLKAGKYYQGDWLFAGVNEGVLDAGESTHLALNFNAYGLAGGLYQKEIRLITNDPVTPTTRVPVALEVTSAPDIDPLSVAVDFNQVFVGDSAIESMTIANVGVDELIIHSSSIDHSDFSTFRGGLTIPPGGEREFYIKYHPQSSGIVNATLTIVSNDPDEGVITVSLSGEGILPPEISVAPGSLSESLILGEQTSQNLRIENTGSGADLVISLKVSEPEGQVKVETSPVFTSADDQVSKDETSAPDLSQYWRQHTRSPLQNTVQATDHVDLVNLKKSLNEKFQSITGLISNRYDFSDGVEGTGINDGGGDMYDGGNYLGTNLGSYIPYSNDLITTSNAFGSGEYFTLKKPGLFVLAANLEEVTTFYVSGNLGADGLGSVDGAVIEMDVAGRTFLGFVKRVYNSGDPSINHLIIVEDNGDATHQFSTNTNYDDHSVNGLSNVRSIHYLLFAGTGSRYYDNHTMTSVMSAYLETLQIGPKWLSVDHTQDTITAGGFAEFNVGFASAEMTVGRHQANIEISSNDFASPQIVVPVSLQVSGIPDIMLSSLQINFGEVEVGQTSEHLLTISNLGNDSLLVGSIASNYPDFTVETTELGLAVGEDHSLTVTYTPTTVATHSGTLQILSNDPNESKVLVSLSGTGIPISNTPPELDGFRLSVPENSPVGYLVDVLQGSDSDGDTLSYGIVSGNESLAFELSGDGRLLINDSAMFNYEQNPLFELTIEVSDGEYQDTAQVWIDVTDLNDRPTIETLVFGIPENSPYGYSVGYLVGEDEDGDSLQYEIIGDNQLVFEVFESGILTVKDSSLLNFEIKKSFDLIVVVQDYALSDTAIVTVNLTNVNDRPVAMDQTFEVFEHSPMGTLVGYLSATDEDGDSLIFEMDSHISSAAFEVSVSGELTVKDPSLIDFEEQEKLYFDVIVTDLSEQATFRVTVTLLDINENTSPSFSDQTFEIPENSPKGYEVGQLTAVDQENDSLIFTILNSEESPFELLHSQLLVADSSRLDYEVNTYFELTMTVSDGAESDTALITIYLTDVNENGVPIILDQSFSVLENSPSGHEIGEVVATDADGDALAFSIIRGNSGNPVTLTSMGVLFINDSSLFDFEVSPVFELVVTVSDDLSVDSATVTIHVVDLDETPENHEPVILDQSFSVEENTRSGIVVGTVVATDEDEDVLTYEIISGNSDRTFALDMESGVLSIDDSTALDFEVNRNISFIVQVSDLTSSDIAIVSIQITDQVEIGLLGLDSDHELLIYPNPSLDGHVSIENGRPIRYLKLLDTSGKVLVFVQGEGRQEIGLELSDFDRGVYYLIIEDVKGQLIRKLILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY90</accession>
    <name>A0A654DY90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="30128" checksum="1998327B61236C83" modified="2020-04-22" version="1">MKTIFITGASRGFGRLWTEALLERGDRVVATARNLTDLEGLKEQYKDRFLPLQLDVTDRHASIDAVNKALKYFERIDVLINNAGYGLFGTVEETTEEQARAQMETNFFGLLWVTQAILPVMRSQKSGHIIQVSSFLGLTTLPMLGLYNASKFAVEGLSETLATEVVHQNIKITLIEPNGYATDWAGASAVQTESGITDYQPVRDAFATAGEDVSSWGKPGATISPVLDLIDNPEPPLRLLFGKVAYAAVEQSLNSRLQQIHHWKDVSIKAHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY94</accession>
    <name>A0A654DY94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14132" checksum="DB41E5067C00B223" modified="2020-04-22" version="1">MKLNIRTSCENAPKKELIKDLTVLFAAYDISQAMQYLEDDVIWTLVGDEPIIGKEPFAAALMEMAHNKATELTIHSIVTHGKEAAINGEIVMGDGNVFGFADFYEFTSAKGSKVRSITSYVVQKVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE0</accession>
    <name>A0A654DYE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026950">
        <property type="entry name" value="Caps_assemb_Wzi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14052">
        <property type="entry name" value="Caps_assemb_Wzi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="529" mass="60388" checksum="32825D6B97074CF6" modified="2020-04-22" version="1">MIRKTLGVLLLLSAMAGKTQVLYPDSYLVDYNKLLELQNDSLRKRIMVNTANVSPNEYDRTPEWNAWGDHYQIYRGGENRFSVLPVISSFGFNSKYPRSYNDGPVWRGKGMNADINFGFRGHFGMLHYTFAPVVYYAQNKDYPRPNGAASEFSYPYSSRIDWVQRYGAEAVTKFHMGQSDLRLIYKKMTLGVSTQNVVLGPSQVNPIIMSNNAAMFPHIDFGTDTPIETVIGDFEFRSYWGIMNESDYYDDNDRNNQRYFQGGGAYYRPSFLPGLSVGATRIHYRDWKIQKFALSDVFLSFADFSSNKDSLSSGSVVNDVYDQMVAINLKWTFEEVGFETYLEFAKNDFSNIRALATEPEHSRAYTIGFIKVFDLGDNKAVKATYEHTTLGQTRLIKLRFSPPYYLHHLAPQGYTQGGQLLGAGIGPGSNGDILMVNYYFPQGMYGMSLQRIRFNDDYAFGTFDPNGDRPFDMEYTATLKALRFVSDFSVGAELSLSNRLNWQYIKGNDVKNLYFRFVLGYQLANLAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYG0</accession>
    <name>A0A654DYG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gntK</name>
        <name evidence="10" type="ORF">MARINOS108_12102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="17702" checksum="A09D68B422AEB99E" modified="2020-04-22" version="1">MAHPIIIMGVSGSGKTTIGHMVADRLGKTFLDADDFHPEENKTKMASGIPLNDDDRLPWLQTLKEQLISTPGVVLACSALKASYRFILDPNHAYSWIYLDGSKELIFERLKKRAGHYMKENLLDSQFETLEVPDDALKVSIDQHPDEIVSVILKSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI0</accession>
    <name>A0A654DYI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-xylose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylE</name>
        <name evidence="8" type="ORF">MARINOS108_11760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="471" mass="51596" checksum="0D28B34834DEFDE6" modified="2020-04-22" version="1">MTERPKTNIKSIALVATLGGLLFGYDTAVISGTVGSLQAFFVDPRGLDELSSNSLLGFAVSSALIGCIIGGAIGGLIAHRLGRRGGLMLAAGLFAISALGSAVPELGFRAIGDGDHTFLTHFVVYRIIGGLGVGIASMLSPMYLAEVSPADKRGFFVSWNQFAIIFGMLVVYFVNYYISLQGDDQWLERIGWRWMFASELIPATLFITFLFTIPKSPRWLALRGKYEDSLQILKNINGEKIANEVFKEIKDAINLNKSSALWSFGFVVIFIGLLLSMFQQFVGINVVLYYAPEIFKNAGSGTNAALLQTIVVGAVNLLFTVIAILLVDKLGRKPLQIIGGLAMGVSMVGLGLTFSMDAMGVGSLVFMMLYVAAFAISWGPVTWVLLSEIFPNTIRDKAMAFAVAAQWISNFVVSQTFPMMNNNSWLVEKFNHGFAYWIYGIIGFIAAWFVWKFVPETKGKSLEEIENLWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK3</accession>
    <name>A0A654DYK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="37714" checksum="E3C32671797E4B8C" modified="2020-04-22" version="1">MLSRVADSLFWLGRYAERAENYSRFIDVNFNLSIDLPPGMKEQWRPLITATGDEVLYKKLYSDYSRENAIRFLAFDKRNHNSIIASVVNARENARQVRENISKETWEVLNDLYHFVEKAAKRKMWKSEDADIFKQIKYKLQLIQGIGYDTSPRNQGWYFTKLGQFLERADKTSRILDVKYHVLLPSVEEIGSPLDFLHWNALLKSVSALNAYKQMYGKIEPGNIVNYLVLNSYFPRSILFCLVNAENCLHEISDAKRGYTNLAEKEIGNLRADLEFADINDVFEFGLHEYLDKLQGRINDISTAVYEQYFKIRPNLMDQSQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR2</accession>
    <name>A0A654DYR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024873378" evidence="2">
        <location>
            <begin position="27"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="420" mass="44355" checksum="5C2CFE917E2A6605" modified="2020-04-22" version="1">MLISSKIYRFTFLLSLFSLLLTIACGGGDGDDEPEPTAEGILINEIVASGDDWIELYNALETSKDLSGYTISDSGNEYELPAGTTIAARGFVVLLCNDLGTGLNTNFKLSSSGESVSLKNAEGTLIDQVEFPNLDNGQSYARFPDGADLWQITGVTTQGESNGSDGAPAINSISRSPLVPALNENVVVTAELISTTGVASVKLFHRFNGSAFSEVAMTLQSGTSYTGTIPGMATEGTVEYYVEAVGTNGSSSFKPASAPDNTDDYLLNTDPLPQLVINEFMASNTSCCPDTDSGEDEFDDWIEIHNLGATAVNLADMYFSDDKDNPFGDKISDDDAAATTIPAGGYLVFWADGSTSQGPTHLNFSLSADGEDVGLFYIDGRTIDAYTFGAQSENVSWGRITDGGDTWGAQATPTPGQANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW1</accession>
    <name>A0A654DYW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ORF">MARINOS108_11554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="107" mass="11753" checksum="08ED51FB6471CC89" modified="2020-04-22" version="1">MAHPLELTDQNFEEIINTDKPVLVDFWAEWCGPCKMIAPVVEELAADYEGKAVIGKVDVDSNPEISAKFGIRSIPTLLVFKNGEIVDKQIGAVPKTALSEKLDKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW7</accession>
    <name>A0A654DYW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">thiL</name>
        <name evidence="3" type="ORF">MARINOS108_12083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="343" mass="37028" checksum="1A9F5EE5C31EFDEF" modified="2020-04-22" version="1">MSEEKRTEIGALGEFGLIDKLSEGVKIYHDTTVKGIGDDAAVYDAGDHFVLLSSDMLLEGVHFDLSYIPLQHLGYKAVSVNVSDIAAMNGTPKQITVSLGLSNRFSVEAVEVLYEGIRAACEDYNVDLVGGDTTTSRSGLVISVTAMGTVEKDKVAYRSGAKESEILCVTGDLGGAYVGLQVLEREKQEFLANPNMQPKLDGYPFVVGKQLRPIARMDVIHEFGTLGIVPTSMIDVSDGLASEVFHLCKASGLGAALYEDKIPIDKETYETAAEFGLDPNTCALNGGEDYELLFTITQADFEKVKNHAEIHTIGYMQSADKGKALVTRSGNTIALTAQGWKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX9</accession>
    <name>A0A654DYX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">MARINOS108_110072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="30510" checksum="1231C5036E1BC4E8" modified="2020-04-22" version="1">MKSFVFPGQGAQFPGMGKDLYDSSPKAKQLFDQADDVLGFKLSTIMFEGTADELKQTKVTQPAIFLHSVVTALISDAFEPDMVAGHSLGEFSALVANGALSFEDGLTLVSKRAMAMQKACELQESTMAAVLGLADEVVEEICAGIDEVVVAANYNCPGQLVISGSIKGVEIACEQLKAAGAKRALILPVGGAFHSPLMEPAREELAAAIEATTFGAPKCPVYQNVDAKGHIDIMEIKSNLVSQLTAPVRWTQSVNAMIADGATSFVECGPGKVLQGLIRKIDSGVETASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZB8</accession>
    <name>A0A654DZB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044023">
        <property type="entry name" value="Ig_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025667">
        <property type="entry name" value="SprB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025924">
        <property type="entry name" value="YHYH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19081">
        <property type="entry name" value="Ig_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13573">
        <property type="entry name" value="SprB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14240">
        <property type="entry name" value="YHYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="569"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="640"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="710"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="781"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="852"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="923"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1145" mass="119622" checksum="7B754D2DEA02942A" modified="2020-04-22" version="1">MPLFTYGQTCVPEDIYAVEDANAVCYEIVDNVRYFHTNNYPDHTDSYNSPFDLLTSDTEYAMCAYPEEASELTPLYEETETTKGCTFTYTFGVGVNGVKYDPSSAEYFENTSTGENNIDWHVEARYIFSANFGNNGGHLNPFGEYHYHDVPADYFADDLSINGSAHSPIVGYSADGFPMYYKYIYSDPEDNTSAIMEAASGFTLKTGTRPGDGVSAPDGDYTGLYYEDYEYFFANTVLDECNGRYGVTPEYPYGTYYYVLTDSYPYIPRCFKGTSVDNTFRVGPGPSCPESSAATDCAVAVAGCMDPFSMNYNANANVDDGSCTYSSTCETSISIASKDNASCFGESDGSVTVSVTGFGDNPTYEWTGGGTSETKTGLAAGTYTVTVSGDDCTDELEITITEPAEITYSVSATDATCGGGTDGTLTFTASGGAGTDYLFSIDNGSTFQSSGLFENLAADSYSILIQETSSGCEITASGTVGESGAPDAPATSGDASYCFGDTPSAMTATGGNGTLTWYADANLASPLTTGASYTPSDAVGTTIYYVTETLDNCESAASSISITVNSLPEVQATADNTAICAGESVTLSGTGAATYVWDQGILDGESFTPEATTTYTVTGTSAEGCSSSDQITITVMELPEVTASASATTICAGESVTLSGSGALTYAWDQGVENGVAFTPAQTTTYTVIGTDSGGCSASSEITITVQSASVEASASSESICLGESVTLSGSGALSYSWSDEVTDGVPFSPTETKTYTLTGTGENGCTATDEITVVVNTPPTTVANASSTTVCSGEEVILTGTGASTYAWDQNVINGEAFTIESTTTFTVIGTDANGCSSTDEITITVNEAPQISATASSMEICAGEEVTLNGSGGATYEWDNGITDGVPFAPTQTTTYTVAGTNDNGCTGTTQITITVNQPPAVLANASATTLCKAESLTLTGSGAASYTWSDEVEDGVPFTPEASGVYTVTGTDNNGCSASAEVTITVIDLPAEISLDNSTLSASTLTGLTYQWVNCADNSIIDGAVSREFVPDRSGSYAVTTSMDGCSVTSSCIEVSVTVLQSKPPQESIGIYPNPVTERLFISNPTNEIQLVEVINLSGELMVRKTDIHQTLTLDVSNWKTGIYLIHMISGEGESWTRVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZD9</accession>
    <name>A0A654DZD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044255">
        <property type="term" value="P:cellular lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="PTHR12563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="183"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="558" mass="64860" checksum="C8737E78777CC021" modified="2020-04-22" version="1">MRRQKARYSEIIPRTKQWPIVQLAKDRKQFIEEVTTESFNNLKHITRGRSLREELEMTVYREKLRIKANPWRVDPKDEKSFWKSVQDRLSDSSALPPEEAKAVEEGLLTEIIRRYAEEISGNFKKNSYRFARGFITFGFARLLNATRVKGFASLFSRQLDLDDKINIVGEPEHIRELAKRGTVVMVPTHFSNLDSILIGWVIQFLGLPAFIYGAGLNLFNLKIFAYFMNSLGAYKVDRRKKNPVYLETLKTYSSQALRRGCHSLFFPGGTRSRSGQIEKALKLGLMSTAIEAQRIMYQEETPEKPARKIFLVPVVINYHFTLEAPALINEHLKRTGQERYYKEADEFTTSYKIATFLLKFFTKGSNISVSIGRGMDILGNYVDNEGNSVDAANQPIDPKDYFISQGKITVDLQREQEYVRILAKRVVEEYHKYNRVFASHLVAYTAFKMLERKNPKLDLYNLLRLPDEDLILDYEEFKKAWKKLRKRILKLERKGKVGAAQHLKEKADEAIVHGLANVGMYHAQRPLIKKGDKIIIQDMNTLYYYHNRMEGYGLEKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF1</accession>
    <name>A0A654DZF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="34963" checksum="F9BFCE7021A8F0BE" modified="2020-04-22" version="1">MYYRRKLLLGILEEFDGVLSHTKLQKVLLLVTRKQSEKSFDFVPYKYGSFSFQANQDLSTLSKKEIIIDKVKTRGSDWIINSDEAFFPTLKKEDQAAIKQTKKEVAKFNQQELVKYTYIKYPYFAIKSQIAEELLTDKEFEKVNAQKRSFDKPAFFTIGYEGISLETYLNKLIINDVKLLCDVRKNPLSMKYGFSKNQLKKACESVGIEYLHIPQLGIDSEKRTDLKTINDYNKLFDEYEKTTLVENSVHLEEIYKLTEKYKRIAITCFEKEPCMCHRSKVASALKQLPRWDIDQKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK0</accession>
    <name>A0A654DZK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024947267" evidence="2">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="429" mass="47953" checksum="09230AC71D986D06" modified="2020-04-22" version="1">MKLTKRLNQTIKPGILSLMLLASTVAEGQSVTVYSCYEMAEDLSPLKQKEIYLSSINSLNQLIQNTHNLPSVTLEASASYQSDVFGLPASIPGVDFPTIPRDQYNMSLQVKQKIFDGGVSKASKAIEALDEQVKQNELDVSLYQIRNIINELYFGSLRLHQQEAVLISLLAESENKTSAARAAFNNGVLLKSELNELAKEQLKVSQQLVQVSHAKAATLSILSTWINREISAEQLELPTPDVNQSFESIDRPELSLFATRNEKLSAMADLTSTNNTPKLYGFANVGYAQPNPLNFYQTDWNSYYLVGARLTWGLDWGASKHQKEILLISQEMTLTEQENFLRQINNDLIKKKSEIEQMKATIVLDEQILQMQNEIVAEAEKQYENGTRSSTDLLTILHEQAQLKMNLSIHSIALAQMGVELLTISGNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL9</accession>
    <name>A0A654DZL9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="32072" checksum="AA39B8BB2A737B18" modified="2020-04-22" version="1">MCRFTFYQGKPIRIGSLITEPTHSLIHQSFNALERDEPLNGDGFGLGWYNHSISNSPAFFKSVTPAWNNRNLIQLARITESTCIMAHVRAATQGLQVSENNCHPFSYQQYAFMHNGDIGGFHKIRRKIVQLLSDEAFEELKGSTDSEHFFCLVQDELKKRDTLPPHDQMSSSLMAAIRKVVELGLEMGVDEPSYMNMVLTDGSISVAVRFTTDIPENADSLYLNVGKRYACEDGVCHMISPGEHEKAVIISSEPLSDDPGWEPVPVNSMVVVKEGYVLDRLTIAMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS7</accession>
    <name>A0A654DZS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="24648" checksum="9F0B140146E1B6AC" modified="2020-04-22" version="1">MCHYFAMDIELSQKFENFIKGKTKIEDFESWVYTNEQLENQLSPEVYTELISLNFHEPSARFEVTKLVKDEIDYGRLHTASLIALLDKLIQREGEVVDLLYQVYDFMNLGYNFLGRLNIFGNFGEQGKSVILLIDETMDEQTKWDKIVYHEPDLVRELTILRDKISTGRILLTGESYSNKYLGEQFEFVEREADNKRSCCTTPPKSKQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV5</accession>
    <name>A0A654DZV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="208" mass="23590" checksum="2053BBE171F9FA7F" modified="2020-04-22" version="1">MSATHPNNRLTEEQRELISELIGNAIKKAVQSMEQMLKIRVNASHITYGVGPLTPIPELDLLGRFKAHLVKLVFSGDIRGAFYFVILDHEVDLINTVCLPPEFKSDKRTETKLMKHGFMSEIENVIAALSMKEISEYLGVQLELRVPQIQIMSGNLINEFFEKENKVHKTAFHVKSVLEGVAVNVAPFFIWILDDNFLRILKLNTSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW0</accession>
    <name>A0A654DZW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module HigA family antidote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="97" mass="11153" checksum="DED16B8A6E721FA4" modified="2020-04-22" version="1">MEKLPNVHPGEVLLEEFLKPMAISAYRLSKDLHIPQTRVSEILKKNRRVTADTALRLSKYFGTTPKFWLGLQDDYDIEEAIGTKTEEFETIEKVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E058</accession>
    <name>A0A654E058_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ORF">MARINOS108_120043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="192"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="505" mass="57756" checksum="5A3303CE696C7613" modified="2020-04-22" version="1">MVNNDNQILVIFGASGDLTARKLIPAIYNLYKKKYLPEKYAIVGVGRSAYDNDTFRKKAVFENEHLKKNGDDSLDEFAQLVHYHSMDTSDAEDYKKLAERLYSIDGYHGTNCNAIFYLSVPPSLYSVIPKHLASVGLNKETNGWTRVIIEKPFGYDLESARALNKSLLEDYHENQIYRIDHYLGKETVQNLLVTRFSNSIFEPLWNRNYIHRVEITSAESVGVEKRGGYYDGSGAMRDMVQNHLLQLIGLVAMEPPVKSDAHNIRNEKLKVFQSLRPMTKDDIRNDVVRGQYLASTIKGESVKGYREEEGVNPESRTETFVALKFFIDNWRWAGVPFYIRSGKKLPTRVSEVVIHFKPNHHHLFMNQTEVNAQNMLVIRIQPDEGILIKFGMKVPGAGFKVKNVNMDFQYSELTDAYVPDAYERLLLDCMQGDATLYARGDSVEAAWEFIDPILKAWKEDPTIPIYGYPAGTWGPENVDDLIEGKNMAWRYPCKNLADDGIFCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C6</accession>
    <name>A0A654E0C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024979417" description="DUF547 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="27407" checksum="213178543C1ED83D" modified="2020-04-22" version="1">MKILIASALLLCSSGLLGQPKDFFSDAQAFFEGYVSSGLINYDSLKNNPVPLDGLVRQIGNYRIAGKTLDEQKAFYTNAYNLLVIKQIVENYPTDGPMTIPGFFNQKTYRVAGRNVTLDELEKEILFAAFPDPRLHFVLVCAAIGCPPIADYAYMPDSLETQIETKTREVLNISWYVRIYKDRTLVSKVFDWYLPDFVNDAGSVKTFINKYRIIQIPDNHDIATYDYDWSLNDSKNAFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D3</accession>
    <name>A0A654E0D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18426" checksum="78DCDD6782D6A698" modified="2020-04-22" version="1">MKALTIIFLFLTHLSLAQDPEEYLNAGYDKYLEEDYKGAILDFNKAAAYNPDNAEIYYLRGVCRSLLGEKKSAINDLDMATSLNPDYADAYYEKGYIFLSDQNAQKAIEEFDKTLALKPNFAEAYVSRGTAKCMLENREGAARDWEKAKELGIGYTEYMICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E9</accession>
    <name>A0A654E0E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024855052" evidence="1">
        <location>
            <begin position="24"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="638" mass="73550" checksum="914D522004CF8C00" modified="2020-04-22" version="1">MFTRSMRTLLLLIVLLTSVKALAFTDTVRVSKNEILILRDTIFAPDKDTVYFVDAEKYRVRSNPYKSSQDFYQKMREKTGQNKVTAQLFDLLYVSPNARSELAPSKNSRTSNTPFMPYEGMRIRNIRIKHIDLLEGSVNDTLRQASSPLSIMVNKVHINTWNTVIRNNLLIDKNEEIDPYLMADNERILRRLRFIEDVRIYVRPLPDGYAEVIVAVKDRFSWGTALNITDFDEFNLALFNRNIAGWGKYASATWFFDTQSIPASGYEIRTGGQNIDKAITNWELNHTNIGDRESWGIDLQKEFVAPGIKYGGGLDIRTIRDSTITLDGEESDHQYYHLHYQDFWAGRSFALPSSYERKNLIVAARLLNNSFASRPFVAVDSNFLYYNRKLLMGEVSLSSRKFLKSNYIAAFGISEDIPLGYRVSFITGRDFNEFYQQNYLGFQLFWSSYIKNFGYLLLNQEIGAFDRTGINEGVVKIRASYFSPLLSSGRYHIRNFMKMSFTKGIDQPPQETISLEGRIRDIEGERISGNNILALGVESILFTPWYFYGFRFAPFFYYNVGEVWDYRPNQKTSYGYQGAGGGIRIRNESLVFNTLEVRLTHFPKSPPGAKKTVFSLSTSIPISFDNIFKYKPALIPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G1</accession>
    <name>A0A654E0G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="507" mass="58126" checksum="6D65357B9F67E2E2" modified="2020-04-22" version="1">MAPKTTLTRTLLFGVGVFLSLFSFAQKEAKSYEKGLESLGEHRYPLALGYFKETAAIDPKYQDLEYKMEIATLLSPEGDDKSLTKILSFESSYGSSDDHYYYWLGQIYTRRYQISEAVSAFEKFHQKIAYAGNAEEESLEMVEHSTQLKEFFNNPDNYEIHQLESPVNSSSSELTPVYFQGENELLFASDRKGSGEKPFAIYYTKSGPNGWEPIQEVKNLGTFTRKNANIEVINDDGKLFLFREENGGDLFYSQPSGSSWTTPVEFDARISNNHLASHFFINEHEDRIIFASDEDTDGLDIYESFRDPANGKWSKPAPFSTSINSDYNEDSPYLSPDEKTLYFSSNRPGGIGGYDIYVSYYNPSSFSWSEPENMGWPINSPNDELHFKMNDNQTSGYFVSDRLHSKGGFDIYFFWEVQKVKIEGRIFDETRGAALTNAEIRFRPYQYLDEYFSSPIDQTGRYSTRIIGDETFKVEIIQNGKILMEEKFEIHDTSGEPTTHVKDFSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y2</accession>
    <name>A0A654E0Y2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="16851" checksum="12096EFF59DD75AF" modified="2020-04-22" version="1">MEPFKQQFQVIWADLDPNAHMRHTAYNDYAAQVRVGLFDELSLPLAELVASGYGPVLFHEDTTFKREVFMNERITVDCAAVAFRKDLKIWKFRQQVWKQNGELACVIIATGAFMSLKERKVVVPPQKIIDMLERIPKTEDFGWME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E102</accession>
    <name>A0A654E102_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="30795" checksum="DCAFE4ED3CDC1B88" modified="2020-04-22" version="1">MKVLFVGTGLIGGSFSLAMRAGGFLSEAGGYSRNPANLDRSIALGIIDQKFDTLELGIQWADWIILSIPVDVISKQLPGILDQLRSGQVVIDFGSTKGKICEVVADHPHRAQFIAAHPIAGTEYSGPDAAFATLFEEKLMIICEGDKTAEKSLASFKKVCQGLKMRLELMEAKAHDRHLAYISHLSHITSFALSNAVLDKEKDGDIILELAGSGFASTVRLAKSSPEMWAPIFMENKEMVLEALSNFLHKAEDFKKMLEENDASGLQKFLESGRNIRRVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E127</accession>
    <name>A0A654E127_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell shape determination protein CcmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="14435" checksum="3D5974705396BC29" modified="2020-04-22" version="1">MFNKQEQKVAEEMSNSSNIIGKGTILEGSLETFGNIRIEGKVIGNIKTKSKAAFGQSSQVDGSVLAQNAEVAGHITGTVEVTEVLVLKPTAVIDGDIITNKLIVESGAVFNGGCKMGVKSKEIKIGKAEEGSLLKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E130</accession>
    <name>A0A654E130_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="148" mass="17236" checksum="8C30582E847E40E9" modified="2020-04-22" version="1">MRILVSTRVQASCLVVKSGFTEQLFLSLNPPFPPVKLLRFDGCEKGDWVALDLNFLLFRQQWISEITEVSEEAASWSFVDIGRKLPFFLKTWEHRHSVKQVGEGAEIVDAIRFTTGSLVSDLLLYPILWVQFLYRKPIYKRWFNKKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E166</accession>
    <name>A0A654E166_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_140086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12807" checksum="79A2BB5343413D93" modified="2020-04-22" version="1">MDINEKKEIRTAIEEKIVELEQRVQDLTVATKPMGLDNAVGRLSRMDYINNKTIDEANLRASEQKLEALRRWLDLIDTEKFGKCSRCGNEINPKRLLFMPESTRCIHCAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E5</accession>
    <name>A0A654E1E5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaP</name>
        <name evidence="8" type="ORF">MARINOS108_120440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="8"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="423" mass="46663" checksum="D7B2B79B2D7FE3AA" modified="2020-04-22" version="1">MHVFDIIALFIFLAGLFIFVNTYFLKLPSSIGLMIMAIVLSVIILIVGLIFPSLQIGAVELEEYDYAEVLYHVVLSFMLFSGALNIDFKKLSKQRTPVLILATTGVLISTFVIGTLVFYMLEFVGIELHYLYCLVFGALISPTDPIAVTKTIRRFNLDKELEIKIAGESLFNDGMAVVLALTLLDIAHAGEDHALSVFETVYIIGADIGGGIFIGLFLGYLGYRLLKYVDNDAVEVEILITLAIVMAGSFLADFIHVSSKQAAVVMGLVIGNEGRGEHVTSAAGDYVFKFWNLMEESLAAMLFVLIGLEMLVIPRRLDYFSAGFFAVNIVLLGRWISVYIPIKLMSVKRSFSPSTIPVLTWGALRGGLPIALSLSLSDFHGKDIIVTMTYIVVACSVLYQGLTVPLLMKMNFTEKKERKVHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1H2</accession>
    <name>A0A654E1H2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">tatA</name>
        <name evidence="8" type="ORF">MARINOS108_20025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="7727" checksum="F9A2C3640CE3B54E" modified="2020-04-22" version="1">MNTVLAFGMPGGWELIVIILFVIIFFGAKKIPEIARGMGKGIREFKDATKEIKNEIDESAKASPSEKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M8</accession>
    <name>A0A654E1M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicarbonate transport ATP-binding protein CmpD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmpD</name>
        <name evidence="5" type="ORF">MARINOS108_11718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005890">
        <property type="entry name" value="NO3_transporter_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01184">
        <property type="entry name" value="ntrCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="30680" checksum="89BFEA152EA245D7" modified="2020-04-22" version="1">MQAQLKDIIELVPETAEKPNMLVCEDLRKVYPTPKGDYVVLDDLQLSIRQEEFVSIIGHSGCGKSTLLTMIAGLNDISGGKIYVDHDQVRDAGPDRAVVFQSPSLLPWLTAMQNVMIGVKQVFPGASRAEKEEICKYYLDKVGLGNDFHKRATDLSQGMQQRVGIARAFALKPKVLLLDEPFGMLDSLTRGELQDVLLEIWQKEKITAVAITHDVDESIFLADRVIMMTSGPYAKIGDELTIPFERPRNRKAVLEHPEYYDYRAYLLNFLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P0</accession>
    <name>A0A654E1P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="826" mass="95690" checksum="9287C90C1554FFB5" modified="2020-04-22" version="1">MNHLVLLLLSVISIQTNPTQGLRFKDNTHPIDERTSYNVFNDQSVEFSGHFSIEFDLSLYSTHQIGYILRIKDAKNSTIYNLFFEEQNDDLVFKFNEEGVSSLVTARLDKDILNKARWIHVGISFNLQQNQLKLSIQDQIHTIEKLDLPDTYHPTVIFGKSDYIIEVPSFAIRDLSIGDGNKYTFQLSEGRGKAVHDEEGNAIGWVENPDWLINDAYFWRLKHSFKSRAVAGSCHNPTNNEIYYFNKDTLFQYNTKTDRANVIVLKNECPINFTTGTSFIDAENNKLYVYEVYTNTNEPSVASLDLTSFEWKTESYDKLQKRLFHHGRFFDAKRDRFVLFGGFGDKRYSNSFYSYSTTTNDWEEILTDLEGDFISPRYFASISYVEQEQSIYIFGGMGNKSGDQIVGRKYMHDLYEVNLETKKTSKLWDIPWDNIEMVPVRSMVIMDSSFYTLCYPEHYTDSFLKLYQYSLQDGVFNILGDSIPIHSDKMNTNANIYYSSSEQTLYALVQEFEDDDIASQLKIYSIAFPAVTVDKLMTQVKSDSSVATKLITLLLSMLFIVVLGYLLLKKRAKSIKQRGSREMSEKGTSPTDEHKPNSIFLFGNFTVFDRSGKDISYMFSSRLTEMFCLILQHSVKEGINSKNLSNMLWPDKEGEKLKNSRGVTINNLRKVLSELDGIELIYENGYYRLTHTPELHCDYINFVEILSSNKLAEHQESFAQIVSRGKFLNNLNEPIFDSFKTSTERKLEPILIVEIEKSYSSGLFLMSIALSKALFEIDPLSDVALEYQIKSLQNMERRDEALIKYNEFLIRYRKVMKQDYPKQFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1U7</accession>
    <name>A0A654E1U7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">prfA</name>
        <name evidence="8" type="ORF">MARINOS108_20222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="357" mass="40091" checksum="D50068E18A23618F" modified="2020-04-22" version="1">MIDKLEAIKKRFEEVSQLIVQPDAMADMGNYAKLNKEYSDLGKVVKKYDEYTHLLANLKSAKEVLETEKDEEFREMAKMELDELAPKRDELEEELKMMLIPKDPNDSKNVILEIRAGTGGDEAAIFAGDLFKMYEQFAADQGWKFSVMSLTEGTAGGFKEIVTSVEGEDVYAKLKFESGAHRVQRVPQTESQGRVHTSAATVAVLPEAEEVDVELNMGDIRKDTFRASGAGGQHINKTESAVRLTHAPSGLVVECQDGRSQHANYDKALKVLRSRLYEIELKKHNDAISSQRKTMVGSGDRSDKIRTYNYPQGRVTDHRINHTVYNLPTIMSGEIGEFIEKLRIAENSELLKAEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E201</accession>
    <name>A0A654E201_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfate_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="12"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="518" mass="55894" checksum="0DFF8BAEB0D6D28B" modified="2020-04-22" version="1">MNIKQDLFKDLERDMLSGVVVFLVALPLCLGIALASGAPLFSGIISGVIGGLVVSLLSKSQLSVSGPAAGLVVIVLGAIETLGSYEAFLTAIVLAGVFQFLLGQMKAGIVGMYFPSSIIKGMLAAIGLILILKQIPHLVGFDSDAFGEMEFIQKDGSNTISSLFTSFEHLVPGSVTIGLFSLILLVLWERPLIKQNKLLKHIPSGLLVVLCGIAINQFFKFSGSDLVVNSSHMVNIPIIEGLSSLSTVFRTPDLGVLGDVNVYITAATLAIVASLETLLSIEAIDKLDPQKRRTPHNAELKAQGVGNMLCGLVGGLPITAVIVRGSANVDAGARSKKSAFIHGLLLLIFVAFLPHVINEIPLASLAAILIMVGFKLTKPALYRQQYGLGREQFIPFIVTIIAILFTDLLIGILIGMGVGVFYILRANYRVAYHYEEKEQDGRSEIHLRLSEHVSFLNKVGLQLSLDYLPENSQVIIDGSQSKQIDHDALELIHNFKKTALERNINFTLKNVPELNSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E207</accession>
    <name>A0A654E207_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="29730" checksum="3226B9AD7F7BE6E2" modified="2020-04-22" version="1">MQTTNPGHQLHLHRYKIIVFALILMMALPGYTQNEASENLLDYDAQWIHYGFQIGLHSSKYKIRYSDAYATDELDSLHSIVPGNLPGWKVGFVVDMNLHKYLSFRILPTVGFYEYDLTYRYTDGRELRELKPATMVELPMLLKYKSSRRGNVAMYVVGGLSPAFEAAGKGDQLDTRERLELRDWNVSVDAGVGFDLFFPLFKFSPEVRYSWGLRDMLTDGTNTYDVALKRLSYQNIAFYVTFEGGPTYLREAKKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E240</accession>
    <name>A0A654E240_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="241" mass="27007" checksum="CD843F05AB2FAF21" modified="2020-04-22" version="1">MSTAGKKMEVEIWSDVMCPFCYIGKRKFEAALAEFPGKDQVAITWKSFQLSPHMVTDPAKNIHQYLAEHKGISLQEAERMNDYVTDMAAQVGLSYRFDQAVVANSMKAHRFSHYAKTQGKQDEAEERLFSAYFTEGKNTDDLDTLVTLAEEIGLDGAEVRAILESDKYTEAVRTDIYEAQQVGVRGVPFFAFDRKYGVSGAQDSQVFLQTLQKSFDEWKKENVSPIEVIDGPACAPGEDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E263</accession>
    <name>A0A654E263_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="307" mass="33485" checksum="79BB4713135C840D" modified="2020-04-22" version="1">MKAIAYTTYGPPSVLNMVDIEKPTPQPDEVLVKIHATTVTAGDVRLRSSNFPPIAWIFVRLIYGLFKPKKEILGHEFSGTVEAIGKDVARYKVGDKVVGTPTMLATGSYTEYLSIPENRNKGVLRLKPKSLSFNEAAALPVGGMTALFLLEKAKLSKGQNVLIYGASGSVGTYAIQIAKAQGARVTAVCSGSNLDMVKSLGADATLDYRSQDYSLLEEKFDIVFDAVGKTSKSKASKILKQEGRFASVQALTSPGQKHLEVLCELADEGKLRPFIHKTFPLQHMVEAHQYVDKGRKKGNVVIEVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E297</accession>
    <name>A0A654E297_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="154" mass="18128" checksum="39721A68551FCC4A" modified="2020-04-22" version="1">MYLILWLLLHPYHVSVCEIVIGTEAPTLQITHRMFTEDLELALRRHTEDPSLHVIEDSSVVMSALKSYFQKNFSLWVNDENKDFVFLRFEIEDDLTWCFLEVTDVRDLKLLHVQNSLLLDLFDDQKNLLHVKSGMLKKSYLLDKETVSAQFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q9</accession>
    <name>A0A654E2Q9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ORF">MARINOS108_20201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="29414" checksum="296DB32A99DC4A30" modified="2020-04-22" version="1">MYPELFTIGGFTIHTYGFMIMLGAVAGYFYVSTVVKRELGISPEKIQNLAILIIVAAFVGGKFFFYLEKPDYYFHPISNMFKGFRTGFVFYGSLLFVIPVTVWYFRKQKWPVWPLMDRMAIAGCIIHLFGRMGCFFAGCCHGLPTESILGITFTDPESQAEPLNTALHPTQLYEVAWIGSTLVILWMFKRYKRFEGRLFLVYIVLYAIGRSVIEIFRGDIRRGFIIDGVLSHSQFISLLIIAGAVGIYFYLRKTQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S7</accession>
    <name>A0A654E2S7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025016625" description="OMP_b-brl_2 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="202" mass="22174" checksum="334EAC0B1E7250E9" modified="2020-04-22" version="1">MKFKILFLATMCIFFTSAQAQRAGLKGGVNFTNLYVDDVDDENMKVGFNVGLFHRSDISNNFAIQPEFLFTQKGSEIQYSGFLGGSGKYRFNLNYLEVPVLAMAKIGSFNIHAGPYLGFLVGAKVKDIDDDGSVNDVESLDRDDFNTFDYGIAGGIGFDFPDGMLGLRYNYGFVEIGQSGVAGQATENSKNSALQLYLGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X6</accession>
    <name>A0A654E2X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="304" mass="34981" checksum="5F59C353410B6229" modified="2020-04-22" version="1">MIKLNIKDETSPLEAVILGIADSFGGTPDLADAYDPKSAEHIKAGTYPKESDMIPEMEAFNRVFEKYDVQVYRPELRTDLNQIFARDIAFVIDDYFFKSNILPDREPELEAIDYVISQMDPDKVIKPPDQVHVEGGDVMVHGDYLFVGTYKGPDYPGFITARTNMEGVQFLKDFFPQKTVREFDLNKSNTIAEDNALHLDCCFQPVGKDKAIIHKEGFRQESDYQYLVDLFGMENLFHITKREMYHMMSNVFSIAPDVVVSERNFTRLNEWLRSHGITVEEIPYAEIAKQEGLLRCSTLPLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E305</accession>
    <name>A0A654E305_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="11568" checksum="275B846C4A798C87" modified="2020-04-22" version="1">MKKFLVIYHASAEAMAAMSQATPEQRGEAMKPWMAWKEALGDKMLDLGAPLSGGVKIKPNGSTEASKKEVTGYSMIQAKDLAAAQLLLAGHPHLQSGCDIELHEAMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E350</accession>
    <name>A0A654E350_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="14767" checksum="0744E5FBB6A28B5A" modified="2020-04-22" version="1">MNDQNRTIIFIHFLTDPAGFDFENPLEQKVRAEKKEGDVLYSLDNFSDSLTLHYAKKLISDSEQITVICQVQGEDVPTGGAFSLLNQLIKKKDSKLFCNRDYAPLKPMMTRLKGRVFATGEELMKMLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E359</accession>
    <name>A0A654E359_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="339" mass="37657" checksum="0A7DDCA1363D5604" modified="2020-04-22" version="1">MKKGSVTIKDIALELNISVSTVSRALADNPLVKPSTRAAVKELAKKYHYRPNFTALSLRSNKTKTLGIIIPQLVHEFFAMVIRGIEDFAYSNDYNVIICSTHESYEREVIDTKALINGRIDGLMACISKETNEFDHFSEFVDRGLPLVFFDCICDEIEAPKVVLDDFDAGYKAVKHLIDQGCTKIAYVGGPINLFINRDRLAGYNKALSEAGLNTRDSWIIHCDSGDYDDGMESTRELVQAREIDGLFAATDMLAIGAIKNMKAAGLKVPEDVAVVGFSNWSIGTLYEPSLSTMSQPGYEMGQKAAELLIQQIDNPDQEFNETVVLHSELLIRESSIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E391</accession>
    <name>A0A654E391_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="551" mass="62906" checksum="A36BA6039E48DD16" modified="2020-04-22" version="1">MRYTISVLLTLSISYLGAQSTDIPLNAPAYHILDEWDVKAEKSVFTTLKPISRRYFAESIEAGAAGSSRADVWDKAYLERETRAYQDSVEENEKPLFGRFFQYPADVFSVGQEDFDLHVNPVIVLGLGRETDSRFDKPIFENYRGLELRGRVDNKVSFYTLLTENQARYPNYVQQVTDSTLAVPYEGFWKAYNNTGVDFLRAQAYIDFNVSKHISAQFGYGKHFIGDGRRSLILSDVGNNYPYLRINTRVWKVQYTNIFAQLIGETTGGTYGLDGIGSFSKKHLASHHLSINAAPNLTVGLFESVIYGDSSGTLKLDYLNPLIFYRALEQQDGSSDNVLLGLDFKWNLWQCISLYGQLVVDELILGEAFSKSGWWGNKQGFQLGAKYFDVFGIEDLNGQVELNRVRPYVYGHETNFTSYSHYNMALAHPLGANFQEVLFSLNFRPLPKLKVQGDLLTARYGDDQGNLNYGRDVLKTYLPASRPGDYDNQMYQGVDTRLLMGQAKVSYQIYHNMLLDLDLIWRRETSDMDKQETTIVATTFRWNFPSRSYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C8</accession>
    <name>A0A654E3C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025063510" evidence="4">
        <location>
            <begin position="23"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="40"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="301"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="602" mass="68792" checksum="ECA4F51A7C201F33" modified="2020-04-22" version="1">MKVLFKTCMAALCGIMLLNVQAQNEAPLLTNMTNREAMTLDGKWRYIVDPMENGYYNYRYKINPNGYFKDQKPETVSDLIEYDFDKSGQLNVPGDWNTQREDLFFYEGTVWYKKAFIYEPSDQRAFLYFGAVNYDAKVYLNGEKIGEHIGGFTPFNFEVTNLLKAGENFVVVKVDNTRKSESIPTKNSDWYNFGGITRSVKLVEVPKTFIRDYAIQLKKGSKTDVEGWVQLDGAQLTQKVQLEIPEARVKLTLTPDATGLAKVSFKTKLSLWSDKNPKLYEVSLTSGDDQVKDQIGFRSIETRGNDILLNGEPVFLKGISIHEVAAFTGGRVIAPEQCLTLLNWARNLGCNFVRLAHYPHNEDMVRLADQMGIMVWSEIPVYWTIDWENQSVFDNAQNQLREMITRDKNRAAVIMWSVANETPISDPRTDFLKRLVVSARGYDNTRLLTGALEPHSEGGYRVIDDALGESLDVIGINNYCGWYGGTPASCAGVEWKMIYDKPLVISEFGGGALQGLHGLPEERWTEEYQEDVYKYNIEMLKNIPFLRGTTPWILMDFYSARRPLPDIQDFFNRKGLISDQGVKKKAFFVLKKYYSEKPIQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F6</accession>
    <name>A0A654E3F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">prmC</name>
        <name evidence="9" type="ORF">MARINOS108_20603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="32025" checksum="A9002A6819B4A14D" modified="2020-04-22" version="1">MNHKVSAIYKESVLQLTPIYGEREAESIINLLLEDHLGITRIHRLTNPERELSESDHEKLRSAMLQLLRNVPVQHVIGFAYFMDRKYLVNKHTLIPRPETEELVELILDENDRHQKLNILDIGTGTGCIAISLALAMRASNVTGWDISEGAVKTAQKNSQALGAQVNMEVQDVFGEIPPQQYDLIVSNPPYIPEADRIEMHENVVAFEPEGALFVSNDDPLIFYRRIAEIGLTHLAPGGKLYFEIHEAFGLATKDMLRTKGYEDVKVFQDLNGKDRMVRAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K4</accession>
    <name>A0A654E3K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="227"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="506"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123836" checksum="CC7F020FCFDFDA43" modified="2020-04-22" version="1">MKIFIQQSLYLMNWMLRIFMIQAVFATVLFANNGNAQYKSVKDIHVNLSFNDTELIESFSTVEQLTDLTFSYDHRVLDKNQKRLTYASKGATVEEFLLFLSKEYGLTFRQVNNVISTQKKKAPFTRDEVEVIIGEVTIKGRVTDENGEGLPGATITIKGSSQGTITDVEGNFTLSVEETAQVLVISFVGYVTQEVSIAGATEVNVSMEPDFQGLQEVVVIGYQTVQKKDLTGSTAIISPESSARVTANSLAESIQGLAPGITVRNGGAPGQSSVIEIRGVGSFADINPLYVIDGMLADANPTINTNDIESIQILKDASAAAIYGSRAANGVIIITTKQGKAGPMKVSFSGKKGVQQLPNRWDVMNSTEFAAMQTAQYENSGLTPPALVGTDFDPNVNTDWQDEIIRMGTLQDYNVSLSGGSGSGTYMISGSFFENEGVLKGRDFERYSFRVNSTSKIGRVTFGENVLLSHSITNTPDAGNPFYDMPQLLPVIPVQGEDYVSEGNPSGWGIGSVNAPSYAWNPVAILDLSQRNSQYSKLVGNAYINVKITDWISYKFNAGLEASFDYSKYLRKDGVWSFNAAVYPSSVADTRSTWFSKLFEHTLNINKEIGKHSLNAVVGISQQSSQREETFAQRSELQQFNGQYLNTINSATGDPTASGSRTLDNFIMGYMGRINYVYDDRYLLTLTGRIDKNSRFAEDYRTGVFPSIAAGWRISEEGFFNVPFISNLKLTGSYGQLGVIPGQVGSWDYLGNLNSNPRAIFGPDQAANVGAYQARIANTQLKWETRISQNVGVEAGLLDDRILFTAEWYNSLSQDAILQIPLPQYLGNLGGNPFVNAGSIRNQGLEVSAAYRKREGAFKWDASVNFTTIKNKVEDVGNQGEGIDYIPTGLTRSKIGRPISEWYLLKTAGIFQSAQEVLDHTTADGTVIQPAAQPGDIRFVDVNGDGQITEDDRDYSGKSPWPTLQAGGQFNASYQNFTLNLQLIGVFGNTIYNGVRQVLDGYQNTNFRRDIQPWTEDNPNTSDPRIGVATDDVALSQNATNSTRWLEDGSYLRIRNLELGYNFSDHLFGESGIQNARLYLSGQNLLTFTKYSGLDPDVVGNGILERGFDAGNWPSSRVYSLGLQFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P1</accession>
    <name>A0A654E3P1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="100"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="441"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="572" mass="63786" checksum="8D4A8860EA7C8D34" modified="2020-04-22" version="1">MPINTTFQIGEKADAYDAIVIGSGVSGGWAAKELTEKGLKTLVLERGRPVEHRKDYITEHKAPWEFDLRGQLTQEEKKEYSQAVRIGYLDKTALHFFSKDSESPYVEEKPFVWARGYQVGGKSITWGRYTFRISDLDFEANQKEGVGVDWPIRYKDIAPWYDYVEQFAGISGEKLGLDYLPDGNFQKPMELNVVEKHLRKRIRELYPERYLTIARAAVLTEPIGERAPCHYCGPCWRGCSTGSYFSSLSSTLPAAAATGNLTIRPFSVVHSIIYDPETRKASGVRVIDSETKETIEFKAKVIFVCASAMASTQILLNSRSEEFPDGIGNTSGVLGHYLMDHHLGMDVNATVPGFLDRTTRGNRPIGFYIPRYRNIGGASDMPDFSRGYGFEGSAYREGWSKAFGMEGFGADFKNKVKEAGEWRVGMWGFGETLPYYDNHARLHPTETDEFGIPKMVFNAEIKDNEKRMRQDCLDSMAEMLENVGCTNITAEDNAAGAVPGFGIHEMGTARMGRDPKTSFLNGNNQAHEVPNLFVTDGACMTSSPCQNPSITYMALTARAADFAVKQLKSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S7</accession>
    <name>A0A654E3S7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017317">
        <property type="entry name" value="Pept_S8_subtilisin_bacteroid-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037903">
        <property type="entry name" value="Subtilisin_rel_GFO_2223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="166"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="5">
        <location>
            <begin position="457"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="536" mass="58634" checksum="7635BB265F0E6B02" modified="2020-04-22" version="1">MAQIKHLLVLAIVLCGHLVFSQKDRYMVFFSDKEGVSFSIDQPEDFLSERAISRRSRMGIAITEKDLPVNATYVAGVRSTGAQVYYTSRWFNAALVQMTNDELIQVTQLAYVDSVEYIAKGERLSDARVATANVAEFKAPSRVTSTTRAQLGLIGADEMHAEGYKGEGMIIAVFDDGFMGVNEYEPFEHIFTEDRLLGTKDFISNSGNVFQFDDHGSAVLSCIASSYGEDVSGTAPNASFLLCVTEDIKSEYRIEEYNWLLAAEYADSAGADVINGSLGYSTFSDKTMNYNYQDMNGKVTVVSQAAEMAVERGIIVVVSAGNEGNGSWKYVTSPADAPGVLAVGSVNPDGSRSSFSSVGPTSDGRVKPDVMAMGAFTTIFYVSGDDGVISTGNGTSFASPQIAGYAAGIWQANPGWSNQEVIEAIKKSANKAFAPDSLYGYGIPHYPIAVTDTTFKVYPNPFRDNIITINFGNLEFDNKVEISLYDIQGRELYVREISTKALPRKLEIEVNNLRSGTYFLSLRSRKFKKTVQLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V1</accession>
    <name>A0A654E3V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25636" checksum="878B35122FF76622" modified="2020-04-22" version="1">MVILSQQMKTSTAILLFTRREKDEIRSKSLHPTPKVIRYFQNRTRNLISKTNLPVFEKVDMEPTQGPIEVRFFLAIKEVFDQGFENVIVVGNDCPQLKSADLILANELLLSRDLVIGPDSHGGAYLIGISKKIFHKDWLVNLPWHTNRFCEVLSSVSENAAHLEPLSDINRPEDFVEVLKTKIRRSILLPLLHLLGQIFLPAVWSFSCKPRLLVANLPLRAPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3W4</accession>
    <name>A0A654E3W4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ORF">MARINOS108_20274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="16354" checksum="DFD6156E98BF6376" modified="2020-04-22" version="1">MAGVNKVILVGNLGKDPEVRHLESGAVVASFSIATSETYKDRTTGERREQTEWHNIVLWRGLAEVAEKYLKKGDQVYVEGKLRTRSWEKDGVTRYTTEVVGDNMTMLGSRSGGSPGGAGNTSQPYEEPSSAPAQSSGSSPMEEGVTDDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X0</accession>
    <name>A0A654E3X0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="15237" checksum="69047D5DD65947DF" modified="2020-04-22" version="1">MVYSASRRVVRTYVEVVRLNHIIVKVLFSLEGQEFVFRAMLSEQEEGLLMIIQDRVTKDHILSGVSGFLYQKPNVHGGYIHKLNSFYFHIRVKGFEGDFTEVYFMGKEELEYQLLDQKRSQDILKVKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E434</accession>
    <name>A0A654E434_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="35213" checksum="70E542A56C65B395" modified="2020-04-22" version="1">MKTNDSYLSFLDIWHVAMWYLFLVAIGLTLIFVIRYWIKYSFAGTLKEKFDVASQYEIKSYLRANYVLAAGIFFFLNTVYDETVVLSPVWFFIRIFVSFCIGTLHIYIAYLIFKYYYPGPLEKKLKKLRYTPRINPGTGNEMKLLSEDEEDTYLDEGMQAEEDAFSVDYDVWIDPETQETKIEKYQGHLSAFECDRCGFQTLKLVKEDILKPATDHEDGEIQKEYECSYCGRVKRKTQKLSKNIDKDSLVAKSTTHAIPNIEAIKVEIHDTDGHTKMFEFQNTQQAKKFLEEFDFSKLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B0</accession>
    <name>A0A654E4B0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PorV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045741">
        <property type="entry name" value="PorV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19572">
        <property type="entry name" value="PorV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024881478" description="PorV domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PorV" evidence="2">
        <location>
            <begin position="34"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="406" mass="44963" checksum="AC8914104B8AEE33" modified="2020-04-22" version="1">MSLRIKQAIWTFVGLLPIGVMAQNNSAYISGQDSSRNPITVAVPFVSFAPDSRASAMGDAGVASSPDEYSVQWNNGKLAFIEDDLGFSFSYSPWLGNIVDDMSLNYLTFHTKIDRIQTIGVSLRYFDLGEIQLTDSNGEPLGLENPREAAFDGTYSRKLSENIGVGVTARYIWSNLSGNITGAPDAKAGTSVAIDLGFYYTKELIFNGMNSELSFGAHLSNFGRKITYSNDSNEDFIPTNLRLGTAFKIDMDPYNSVAFLLDFNKLLVPTPPIYEVDSDGNLVTDNNGDPVIAKGEDPNRPLLSGAFGSFTDAPNGFSEEMQEIMISTGLEYRYREVFAIRTGYFYEHQNKGNRKYFTAGIGFKYQVFGIDFSYLVPQENNHPLGNTLRLSFVFSFDTKDEEPTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D5</accession>
    <name>A0A654E4D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="28631" checksum="F66ADF63B4AE3090" modified="2020-04-22" version="1">MKNVALITGASGGIGLELARIHAQTHGDLILIARSTSKLEQLKKELEAAYGISVLNIPKDLSIPDAAQEVYNQVIAANIQVDYLINNAGFGDFGNYHETEWEKEEMMINLNILALTQLTKLFGSDMVERKSGKIMNVSSTAAFQPGPLMAVYYATKHYVQAYSEALYEEWKGYGVSVTALCPGATQSGFQQAADMEDSRLFKGKKLPTSLEVAEFGYKAMMKGEMTAIHGVMNTILAGSAKFTPKKLLLKVVRKLQEKTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q6</accession>
    <name>A0A654E4Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="701" mass="80361" checksum="621612A5DEEED1E6" modified="2020-04-22" version="1">MCNKCIRNMTTRSKYYDYLCSLVGLFIIIVIHSSCSDKGQNDLDVKRTEFQRARSSYLSSLEQKIKGKIDEDEIIPIVNEAIRNGYHLEVLRLIESEISKRPADANLHSTLANILHAQGLFEESTDYLENLNFVTDPNKITARLLEIKQDNHDAQGVKSIIDSIEDTKYGIFGYNLASAFRLNKQLEKALDVNYESIDSGTGSYFNSIYARNISEIQRKLKNKIVADYFYCLFQPNSHPKDFQRLSKYYHENEYFTLTSSSLIFEKNQIDKIQIIQDFQILCKDSANRLEIPLSIPSTNVGNIDVKISPVRQFNYTTETHRFNKIISINFDDQILKREILDIKVSFYTTLSDLGAWKRLTYRIFEPVNLIKIKLTENEILDKTYLEDQDVGDIKKLSSKEYEILLKDDKLIETVQLDFSDSNQISWITNKLVLISCLLAIVPLFVCILIYVLNVRVGVKFGLVAAALYILSPNILEWTATNPISWIESILAKYLSPETGFSQELLTTMLISIDLVSVIFISWFLRDLNRITKNLKFGKTGFFLYPIILPFFGTTLLLFYSSQQTIEYGGWYYTSYLLVFSALLIGLLSFLVMRRVTPNWIYILVGGVAGIIITKLASSNEFLQIGTNAIFLIGATIYIYGEWRKAKFIQEQPELQSSSSVVSRIEKDIIFALDKYSYLIKIGTIISGLAAFVIILKDLINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R7</accession>
    <name>A0A654E4R7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="319"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="445" mass="50105" checksum="E81424031AA5D979" modified="2020-04-22" version="1">MKKLFMTLLAATLFFGCKENTAYQAILNDPETFNGAMKQLTDVIVYDIFSPPVASRVYSYSSIAAFEVLAISNPDTLISLGGQVTDFTTPPAPPAGINDKLASLHAFLTVGKALIFSEDKIDAYRENLYKNLEENGLPASVKEKSLAYGELVAKHVMAWADGDMYKQTRTFPKYTIRNETYAWKPTPPDYMEGIEPHWNKIRPLILDSANQFPPVPPLELTMDKDSEFYRQLAEVYEKGGGQNEENTQIAKFWDCNPYVSHHRGHAMFATKKITPGGHWIGIVAIATRKAGNNFSETVEAYTRTSIALFDGFISCWDEKWRSIVVRPETLINQYMDEEWVPLLQTPPFPEYTSGHSVISRAAAVTLTDYYGDNFSFEDTTEMEYGLPQRDFNSFLEASEEAAISRLYGGIHYMMAIENGVDQGEKVGDFVVQNLQTRRNKALATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V6</accession>
    <name>A0A654E4V6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="52"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="849" mass="95259" checksum="3573085703506F6C" modified="2020-04-22" version="1">MKKLILSSVLLFLAWITLGQTPIEDYLPQNVSYDLAIPTPEEILGYEVGEWHVSHDQLVSYMRELARVSDRIALQEYGYSYEHRPLMVLVITSPENHLNLEAIRSEHVQLVNTKGSPNSDSKLVHYMGYSVHGNEASGSNAALLAAYYLAAAQGPWVDRLLSETVILLDPSFNPDGLQRFSTWVNMHKSANLVSDPSSREFDEAWPGGRTNHYWFDLNRDWMPVQHPESKGRLSLYHRWKPNILTDHHEMGSNSTFFFQPGVPSRKYPLTPQNNVTLTEKIAQYHAAALDSVGSLYYSKEGFDDFYVGKGSTYPDMNGAVGILFEQASARGHLQENQFGSIGFPEAIRNHFVTSLSTLKAANDLRADLLKHQSLFYQESIKLAGADPVKAYVFGSEGDPARAFHLMEILHRHDILIYPVEKNIKKGTQAYSTGSYVIPTNQPQYRLIKALFETRTSFQDSLFYDVSTWTLPLAFNLKYDELGARDYVQTQLGEVIATPQFPKGRVVGSSDYAYLFEPNGYYTPRAIMRLLKAGIVTEVNHSIHTDRDRSYVRGSIVIPVGLQREKRDVIEAIIQEIAVLDGINVYGLNTGLAIGGSDLGTRQAEVLTMPKVAVLVGDGVDSNEAGEVWHLLDQRMDMQVTLLPVEALNRTDLSRYNRIVMTDGNYRAISDTGVENLKQWVTRGGVIVTWKRGGKWLSDKEISKVQYAKAVPDTTGYKKYLELDQNRGAQVVGGAIFEARVDLGHPLSYGLESAQIPLFRDHSLMMKKASNPYAYPMVYLDTPLLSGYISDERLKQISATPAVTISALRKGRIITFADNPNFRAFWYGTNKLFLNALFFGQTISSAAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E569</accession>
    <name>A0A654E569_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Xylose isomerase</fullName>
            <ecNumber evidence="2 8 9">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">xylA</name>
        <name evidence="11" type="ORF">MARINOS108_90116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8 9">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the xylose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 8 9"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0859">Xylose metabolism</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD21441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="444" mass="49255" checksum="F9290564D5A6C2BD" modified="2020-04-22" version="1">MSKQIILGDKEYFSGIGKIAFEGKESDNPFAFKYYDENRVVAGKTLKEHFRFAIAYWHTFCGTGGDPFGPGTKDFPWSTAGDAYRRAKDKMDAGFEFISKIGAPFYCFHDFDLIEEGDTLAESAKRLDFITDYAKEKQAAAGTKLLWGTANLFSNPRYMNGAATNPNFEVVAYAGAQVKNALDATIKLGGENYVFWGGREGYMSLLNTNVKSELDHLAQFLHMAKDYARSQGFKGNFFIEPKPMEPTKHQYDFDAATVLGFLREYDLLADFKLNLEVNHATLAQHTMQHEMQIAANAGALGSMDANRGDYQNGWDTDQFPTNLNELTEMMLVFLEVGGLQGGGINFDAKTRRNSTDLADIFHAHIGGMDAFARALITADAILTQSDYSKLKAERYASFGTADGKAFEGGKLKLTDLAKIGAGMDNIPLQSGKQELFENIINQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C8</accession>
    <name>A0A654E5C8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium-dependent dicarboxylate transporter SdcS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sdcS</name>
        <name evidence="7" type="ORF">MARINOS108_60006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="501" mass="55257" checksum="0C2C7AC29902B4F1" modified="2020-04-22" version="1">MIRKYNKTFALILGPLSFLIMEMVGPPESMNIEAYHVLASTVWIAIWWVMEAVPIAVTALLPILLFPMTGALDIGSTTESFGHKYIFLYMGGFILAIAIEKWGLHRRIALNIIRIIGSNVSNIILGFMVATAFLSMWISNTATSVMMLPIGTAIVSQFKKNTNGSAHDGNALGKALMLGIAYSASIGGIATLIGTPPNLVLAGILEEIYNVKLSFFEWMMFGLPTSAILTVICWRYLTKYAFRFDEIEFPGGKGEIRDMIRALGKISFEEKAVLVVFICTAFAWIFRSLLQKVIPGLDDTIIAMTSAVVLFMIPDKTRSRKLIKWKEAVKLPWGIILLFGGGMALAKGFTSTGLAEWIANQMTRMDGLTLIVLILVLVTIVNFLTEITSNLATTAMLLPVLAPMALSFNLHPFMIMVPVTLAASCAFMLPVATPPNAVVFGSGYLRIPDMISSGFWMNLISIMLITIATYFALPYLWDIDPNLFPEGFKQFQNLNSTNLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G3</accession>
    <name>A0A654E5G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_50064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024913650" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="117"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="412"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110420" checksum="E522968184F8AEA1" modified="2020-04-22" version="1">MAHQTARWSWIMMLLLTYSSYAQMTVSGRVTDNETEEGLPGVTVLVKGSSTGTVTDIEGNYRFSVPEANATLVFSFVGFAPQEVEINGRQIVDVALSADIQALNEVVVVGYGTMERANVTGAISTVDVQEITKASVPNVVEAMRGQVAGLQIVRTGGQPGSGVTFKIRGNNSLGASASGGSNIDDVNQPIIVIDGVPLVGGNLAELNPADIESINVLKDAASASIYGSSGANGVILITTKNGRPGRTQIKASASTGIVNIAQRPNIMNGDEFLQFKFDAFKAGDATVPDPTVTSLLDMVEEQNYIAGNEVNWLDEVLRTGIQNNMGVEVSGGSAQGNFYLSGNYYGEKGPIEASDYKRFSTRFNANWNINDRITVGANVQLSKSFSDQRTRIVGFENNAVPSLSALVGTSPFGNLYDAEGNYSKFATEDLFAVNPLHKFNESEFDVNVTRAYINPNINIEIIDGLTYTLNTFAQTRMEFFGRYQSDNFTDDALNLAQVRESEEVNYLLDNILNYTREFGDHGVNATVIYGGQVNKWTRFEMNARNIAADELGYYGIHSAPAAQQTIGTNTSDWAKYYVATRLGYNYQGKYSATFTVRRDASSRFLGDNRYGIFPSASLAWNAQEESWWFGGNNFNMFKMRLSYGVMGNDNINPFSYQAGTYPTSIPGTENTGFRPGTTAGNKNLKWETSKQFNVGADFGLLASRISGSIEVYNTATKDVLLYQQIPAPLNNGYSQFPSNIGETANKGIELSLKAVAMESNDFSWTPSLNLAANRSTIEKLNETGPDGEPLDDISNGWFIGQDFREIYDFKYLGVWQADEVADAIVTTFGTAPQAGDAKIDDVNGDGNIDFDDRTFIGNPTPSWYGGINNVITYKGFTLSVLFEAVMGVKRYNSIYGGYNSARGNTIAINYWTPDNPSNDYPRVGEGSPMSGPFGAAIFTEDASFVSLRNISFSYNLPSKWVKKASLGGVTLSIRGNNLKYWTDYTNAYSPEITNTDQYPVTKNWTAGLNVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5M9</accession>
    <name>A0A654E5M9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024917269" evidence="1">
        <location>
            <begin position="23"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="410"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="793" mass="88811" checksum="547AFDC84F108463" modified="2020-04-22" version="1">MHFIKSILVTLSSMLFCGALYASGFVAEKADSLYRHMSTIQRLNQLVLVSTSQATVPTVSGDFGGIYFSEPLKISLGKSDQLIVVQLDERLNPFTEELVNLPGLYTLAALSRADLLNTYLYHLEAASKSRGIDMLILPEVNHPGTTVDLVLQKMKAHDPDFFRDKKSLSFTSARKKKELIRVFEENDFWVIPEADTQTVSSRLEKYSDKIASTVSLEDKIRHNILARLLSPAMSPTDQIPNQLAVAISKASIIPLQRVAGIFPIQSDTISFVTNQPYGPMANMLRKYAYVKTAYGEILTSHSPIVLDNNSFIPPGILSGDRDIIFVGEIENLRDHAEMLDAALVYSHPSEIYSYVIPQQLFGASDISGRLPYAVEKLSTFNNDEVAGKKILGYAPAEMTGLDKSALFKIEQIMADAISSGSTPGGQLAIAVDGAIVLDQAYGFLTYDSLIPAEKTTLYDLASVTKVTGTLLGIMKLYEDGRLDLDARIDEYLPAYQNSNKGHITARALLAHNAGLKPYVPFWQKVLSADMLETFFYEDEAALLADRRSYHTRPNTIVQDTLKNWIIQSPLIQYDSIPFYSYSDIGFMILHQVVEQISGQPLDQYLSETFYQPMGLRRLTFNPLDHGFQRFEIAPTEHDYYFREELVWGEVHDRNAAVFGGVAGHAGLFATSHDLVVILQTLLQGGTYGDHQFLQASTIQYFNQCFFPNNRRALGWDKKDDKVGNVSAFTTSESFGHTGFTGTMIWADPQYNLIFVFLSNRIHPNSNNYKLIQKNIRTKIQDVVYEALMAKWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Q3</accession>
    <name>A0A654E5Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family hydrogen peroxide-inducible transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="36258" checksum="3BA526F3C48679E9" modified="2020-04-22" version="1">MTLNQLDYALTLWRIGSFSKASERLGITQPALSSQIKKLEEEIGIKLFNRNTSPIEITRDGQRFLERSQQILTDARRLINFSQELSQQYNDVIRVGVIPTLAPFLVPLFSDDLQKDYPEFRLDIHELTTENVVAGVRDGSLDVGLISTPISVAGIVFEPLFYEKFFLYMSFQPETKTHFDLQDISYDELWLLNEGNCFRDQINNFCDLNKIRQHKHFIYRSNSIDALIRIVDTKGGMTILPELSMLSLNEEQEERVIPIGGKPKAREISLIMTKHYDKQRFIDKLGEYIRKNIPRHMLSPQDYEIVDPQINIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5R2</accession>
    <name>A0A654E5R2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_60117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="19762" checksum="DE007DF7AFA3BE1D" modified="2020-04-22" version="1">MKFIEFLKSTDSLTIQLLITAALVLLYAILNKVTSRLIKRYGKRREISTPRVVYTTKYFRFVLVVFILLLLGLTWDISFEGLSVYFLSFFTVAGIGLFAAWSILSNITAAILLFFYFPYRIGDRIRIVDGDNSIEGIVNDLNMFSIIIKNDEGQKVTYPNNLALQKAIILIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5T5</accession>
    <name>A0A654E5T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">kmo</name>
        <name evidence="6" type="ORF">MARINOS108_60137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="5">
        <location>
            <begin position="6"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="49894" checksum="AD8BD853DE2DBEF8" modified="2020-04-22" version="1">MEHKEISILGAGLVGSLLAALLSQKGFGVDVFEMRGDPRSQKIGEGRSINLALSHRGITALKQAGVFEKIEPALIPMMGRMIHDLKGNLNFQSYGRASQHINSVSRSGLNNILIDHAESHGVNFHFGHKCSQVDLESVAMDFDDPSVRSVSSEVLIGADGAFSMLRRALEKTDRFNFHQHYIEHGYKELHIPAVNGTFAMEPNNLHIWPRGSFMLIALPNPDCSFTCTLFFPFEGDLSFDSLKDDDSVLRFFETYFQDVLPLIPDLVAQFQTNPTASLVTIKTSPWVKNRSLLIGDASHAIVPFYGQGMNAGFEDCRLFMEWGEKLKFDWDKLLPYFSKHRKADADAIADLAMKNFVEMRDKVADERFVAIKKLESRLQEAYPDSWIPLYSMVTFSDIPYSKAKKLGELQEQIMRALPDDFDPMSHPLVPIIESFNALKKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5W2</accession>
    <name>A0A654E5W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rho</name>
        <name evidence="12" type="ORF">MARINOS108_20128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="192"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="310"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="322"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="559" mass="62981" checksum="1B9F86B08483FAA8" modified="2020-04-22" version="1">MYTLDDLSVRLLSELREIAENLGVKNAKKTAKKDLIYEILDKQATLPDSEIQKIKKEEKKPESKPESKPESKSESRPPRPANKKRENVKENKPTEKAEAKSPEDLLKSLDIEIETESSAEAPAAKGGEAKEQKPREGKSEGHNKPNKRRENERSEDRPKSEDRESKERKEPRNEHKGRKAQFNEDIKEFDGVIENEGVLEIMQDGYGFLRSSDYHYLASPDDIYVSPSQIKLFGLKTGDTVKGQIRPPKDGEKYFALLRVSSVNGKTTEEIRDRIAFEYLTPLFPEEKLNLCTKADNYSTRILDLFAPIGKGQRGMIVAQPKTGKTVLLKQIANAIAENHPEVYLMILLIDERPEEVTDMARSVKAEVIASTFDEQADKHVKVSSIVLEKAKRMVECGHDVVILLDSITRLARAYNTVVPSSGKILSGGVDANALHKPKRFFGAARNVENGGSLTIIATALIETGSKMDEVIFEEFKGTGNMELQLDRKLSNKRVYPAIDVPASGTRREDLLMDAEELKRVWILRKFMSDMNSNEAMEFLLSKMKGTRNNDEFLISMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E712</accession>
    <name>A0A654E712_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="256"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="385" mass="42997" checksum="4579007711B0ED95" modified="2020-04-22" version="1">MVRHSSRIELSQSSLTNNINFIRKKVGKDVRISSVVKANAYGHGIAQFVKMAERAGVDHFATASAFEAEEILEVKTEAADVMIMGILYDEDIEWAIEHGIEFYVFNYERLPVVLEKAQKLGIQAKVHIEVETGANRTGMNAREFPDTLAFLKKNHAHVAFKGLCTHFGGAESFSNQFKITAQQGRFKEFVKICEKKRVIPEICHIACSAAALAYPDTVYDMVRMGVAQYGFWPSPDIYYMHMQAGEAKGNGSLKRLFTWKTDVMDVRDVDAGEFIGYGTAYQATQDMKVAVLPLGYSNGYPRGQSNRGFVLIKGKKAPIVGLINMNLFMVDISHISNVEVGDEVVLVGRQQNNTINISSFTQLTQLLNNEMLSRLPSAIPRRIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9P7</accession>
    <name>A0A654E9P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Biopolymer transport protein ExbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_120211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024987900" evidence="8">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="141"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="29284" checksum="413BFA7FC34FD5C3" modified="2020-04-22" version="1">MKQLFTLLMLAGVFTFSSVNAFAQDSPDVASDTIAAEADSVEAPVEEEPVAAVVEEIVEPEEEADATFHQVVKEQFIDGGPEFMGIVLLCLILGLAVAIERIIHLNLATTNVKKLLTSVESALSSGGVEAAKEVCRNTRGPVASIFVQGMMRMSEGIEMVEKSIIAYGSVEMGKLERGMVWISLFISLAPMLGFMGTVIGMIGAFDAIAEAGDVSPSLVAGGIKVALLTTVAGLIVAVILQLFYNYLVSKIDSLVNSMEDASISLVDILVKHNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAT7</accession>
    <name>A0A654EAT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative naringenin-chalcone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="228"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="366" mass="40286" checksum="EAC36316065D8046" modified="2020-04-22" version="1">MSSFISSIGTAVPANRISQSDIALFMTKHLGLKPEKEKLLTLLYRASGIQYRHSVIEDFGKNPTDFTFFPNAHNLEPFPKVGERMKKYEQEAIKLSISAVQDCLGTTEATGITHLITVSCTGMYAPGLDIDLIERLKLPTTTQRTSINFMGCYAAFNALKIADQIVRNNAGHKVLIVAVELCSIHVLKNDAEDSLLSNTLFGDGAAAVLVEGEDPNKTQLAMAAFHADLAPSGKPDMAWHIGDFGFEMKLSVQVPEVIRSGIASLTQKLLSQLSLNLSDIDYFAIHPGGKRILEVIEEELGISRDQNVHAYEVMRNYGNMSSPTVLFVLQRLMKNISNQDEHKNILSFAFGPGLTLESMLLKIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBW6</accession>
    <name>A0A654EBW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospho-acceptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="240"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="466" mass="52678" checksum="61E025438F4EF135" modified="2020-04-22" version="1">MFFFLTGKYRSTLLDHLPKSNALEKRLFEYICLIQFVIMTYLMSRALLNFGWTALALMDLVVALIGLLFYLLSKYKGYFNLLRIPLIGFLFAASVFFWYRLGGFYGTTATAGISVGLVAIVISPARKKIFFFLFSAAFIITLVIVQLQTNWIDSTIDKSVFPINYIIFSMAILIITYMVKSEFDKERRKAVKQNIRLQALNEKLVETISQKEQYINELGQTRDRLIESEKMASIGRLTAGLAHELNNPLNYIGGNVQPIIQDLEDIKQAMTYRQLAQTQQTFTEIHNLLFNIIEGSQRASDVIDNLLKISPKAVENQVAKISLNELVGRTCVLLQNAHPEIHFWIARNEKLVILGNPTEINQVLLNLLKNAIDAVQDCKKGKIIVEVYWENDQSIVNIKDNGSGIPAANLSKIFEPFFTTKEEGKGTGLGLYISHGIIKKHGGKIEYSALDPGTCFKVSFPSFQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED28</accession>
    <name>A0A654ED28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="SSF82093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="134" mass="14687" checksum="5321A78FDB272D83" modified="2020-04-22" version="1">MKKSHIFGIIIIAIAIVVIMTTAGDASAYVTFEDAKALAEKGNNNKIHVVGKLKKTSEGEVVGIESSPDMLSFKFEMLDENNVSQVVYYPNPMPTDFLRSEQVVVVGAYQNGNFVADKILLKCPSKYQEEGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFD5</accession>
    <name>A0A654EFD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP transporter substrate-binding protein DctP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00787">
        <property type="entry name" value="dctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024978497" evidence="2">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="325" mass="36569" checksum="C11F597ED95D1B57" modified="2020-04-22" version="1">MRYLLILICAALVSACATSSETRELKLGHSLAVSHPVHTGMVFMAERLEEISGGKMKMTIYPSGQLGNERETLELLQIGSLAMTKVSAAVLENFAPNFRVLGLPYIFESEEHMYRVLDGEIGEELLGQGEQYRFRGLCYYDAGSRSFYTKDRPVYTPEDLKGLKIRVMKSNTAVNMVNQLGGSPTPISFGELYTALQQGVVDGAENNPPSFYSSRHYEVCKYYTLDEHTSVPDVLLVSMVWWNRLSEQEQKWLKQAATESVSYQRVVWAESVKESLAAVKAAGVEIIIPEKEDFSSVVNPIYEAYKDDVEKFELIMRVRALADEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSE8</accession>
    <name>A0A654DSE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="32609" checksum="1A5704AC55DE4BAA" modified="2020-04-22" version="1">MEKMTDKKHIDGRSDILSNELIKEISDRKHAQNLLSVFVKYAPGAIALFDREMKFLVVSDRWYRDYDLSENDITGSSYYDVFSGATDKHKWESYHQRALKGEKLRNEEDRLIKEDGNVIWLKWEMLPWFDKFGVIGGVIMSTEVITHKKKLEDDYRKSRQLLEMAIETGQIGFWHWMEQNNRLEWNDQMFRLFEFDESDFTGDGETFFDIIHPDDEARVRGLLNRAIAERGQYHTQYRVICKSGVKKFKEHGKVFLDDGLLRMTGICQEISELNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT12</accession>
    <name>A0A654DT12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease, SulP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="441"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="575" mass="62934" checksum="8827447B3165E531" modified="2020-04-22" version="1">MKLIHQILPITSWLPQYKKTQLNGDLFAGLTVGIMLIPQGMAYALIAGLPPVYGLYASIVPQLIYALFGTSRQLSVAPVAMDSLLVAAGVSVLATEGTDAYIGFAILLAFFMGAFQLLLGVLRLGFITNLLSKPVISGFTSAAALIIGLNQLKYLMGVDLVKSNKVHEILWDAVQSINQTHLMTLAIGIVGIVIIKGVKRIHSSIPGALIAVIFGTALVYFMQLESAGVSIVKTIPDGLPSFKLPDLSLGQLGELIPLALTISVVAFMEAFSVAKAIEAKKRNYKVQPNQELVALGAANLIGSLFQSFPVTGGFSRSAVNYQSGAHTPLSSVISAVVVSLTLIFLTPLFYFLPKAILASVIMVAVAGLIDWTYARRLWKDSRVEFALLIATFLITLNFSMVPGIVSGIVLSILVLLYRSAYPHIARLGRVRGHHEFRNIKRFKDLEQWEHVLILRLDAPLTFINIQYFKEYIENAVDDAQGRIETLILDAGPLSYLDATATSGLKDLLDFLHEKKIEFLICDLIGPVRDTMKRTGLNEVLHKENVFFDLNEAVKFATTHKQGDYKDYALQSDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTA1</accession>
    <name>A0A654DTA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024889540" evidence="1">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="316" mass="35369" checksum="A9FF08559585E4C5" modified="2020-04-22" version="1">MKFRLSIGLSLLWYATFAQSPLHSTLQNSPLGYTLITPPGTAKGLIVFIPGFAQTADQLLQETEFEKLAYLYGITTIVVPCGRKMYADGQVVKLLNEAIIATLSDYNIAPNKVVMGGFSAGGTIALKYTQYCLKYPESYPIKPKAVFAVDSPVDLKEIYSYMERELEKQYSEAGVSEAYVIKALMERELGGTPTEVPVRYQELSPFTKGAKLGGEAEVLKSFPIRLYHDADIQWQLKNRRRSFYDMNIAPASEMINQLMLLGNTRAELMMTVGKGVRSNGERHPHSMSIVDEQELMIWILKHLEVDTNPAHKKASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTK0</accession>
    <name>A0A654DTK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5808" checksum="B3111D79E9A9C627" modified="2020-04-22" version="1">MFYGSKLTEESEETLKKCDKYGYYSSKHPISSLRLHVWYRFTTFNTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTW1</accession>
    <name>A0A654DTW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coproporphyrinogen-III oxidase, aerobic 2</fullName>
            <ecNumber evidence="5">1.3.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hemF</name>
        <name evidence="5" type="ORF">MARINOS108_10061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="307" mass="35824" checksum="3FF864C22ADDC43D" modified="2020-04-22" version="1">MEQRKQVENWFKNLQDQICAGLTTLDGKSQFREDLWDRAEGGGGRTRVITNGNLIEKGGVNFSAVHGPLPEKIQKGLALSPSEFYATGVSIVLHPVNPWMPIIHMNVRYFETTPLDQNEKGTYWFGGGIDLTPHYITPEDGGYFHHQLKAVCDQTDPSFYPRFKQWADDYFYIRHRKETRGVGGIFYDRLHPETEEKSFNTLWAFQQNVGNAFLPLYEYYAHKYRGKPYEETHKNWQMVRRGRYVEFNLVWDKGTKFGLDTDGRTESILMSMPPLAQWHYDHQPQANSPEAETLKWLKKDINWLDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU94</accession>
    <name>A0A654DU94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041607">
        <property type="entry name" value="HU-HIG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18291">
        <property type="entry name" value="HU-HIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HU-HIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="16129" checksum="22840033AAC5B342" modified="2020-04-22" version="1">MALKFSVVARKNPSDPNAPFKYYPQPVTSGESGFKSMARKIQKNTGQNYADVIGVLAALEDLLPDEIKNGNIIRLGDIGSFYPRYKSVPSERAEDVTSRNIEHVNIMFRSNKEFLEQLNTTLAFEKVDAGSVKAADEEVPEETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUD1</accession>
    <name>A0A654DUD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="47" mass="5425" checksum="0623977E216D54C7" modified="2020-04-22" version="1">MWKMRMPFLPSLPHTFAIRSNPSITKDAKKSDAVLPSCQYKKPSLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUE0</accession>
    <name>A0A654DUE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="596" mass="63464" checksum="977524CEAD258B44" modified="2020-04-22" version="1">MRKFNFAMAFVAGAIIFSGCTLGKMIKLAANQDLQVTPNPLEVHGGAVPFQMSAVLPPKMLPTGKVYTINTIYQYGDQEIAVGSIEFKAEDFPNSSSSTSRKSGDFSIPYQDGMNPGTLYVEGVAKDPRSGKSKTSPRMAVAQGLVMTSSFAKPVTFSSYADHGYNDKEELVPTKVDFFFAQGVATLNPSLSFDGSSNRSKSNDLAAFIAEKNVTRTVTITGTHSPEGTERINSGLSENRAKAIESFYRKQMKRYDYKGMADSIKFILKPVVEDWSGLKVALVSYTGISDDQKAAISRIINGTGSFEEKEKELQKLPAYKTLLDKVYPGLRTAKTEILTVKPKKSNAQIAVLAKQIANGSISADTLTTSELLFAATLTPSLDEKAAIYKAATKSGAWEAHNNLGAVYLEQAAKAEGADKTKLVQDAITQLEIAKNKSKSAKVSANMAAAYVMQGEYAQALTSIGDAEAASPSNTTASNIKGMKGAIQVMNGQYEEANASFASSAKSATVTFDSGLSQLLSGNYDGAKSTLGEIATNEKLGAEANYLIAVASARQNNAADVASSLKAAVSKDPALKDKALNDLEFTNYADAVAQAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUI0</accession>
    <name>A0A654DUI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="227"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1112" mass="122273" checksum="18D428391488374B" modified="2020-04-22" version="1">MMKPQPHKAKHSSFSFFRIWLPTLFLLLASEIASFGQTKSIDEIYVSLSDTNTQLLSVLKNLESQTGFQFLYNEGILDVNNRVSLEASSRPMGDVLRDLSKESGLMFRRVNNDVFVTTKDEEQNQEENTAPVQEAWTIKGKITAEDSPSGVPGVTIVIKGLNRGTVSDIDGNYELEVNRGDILLFSYIGYQSEEITISNQTQLNIDLTIDLGELQEVVVIGYGTVLKSDVTGSVASVGSEALTAYPASGVTQALQGRAPGVSVQSNNGDPGGSYKVRIRGGTSINASSDPLFVVDGFPTGSAPPAEDIESIEILKDASATAIYGSRGANGVIMITTKRGKAGQTRVDFRSSYSVQSEINKLDLLDASEFAEYMNAVEASGGRDPMFDDPAAMGKGTNWQDEILRRGSIQNHSISISGGSDNMKYYVSGIYYDHQGIIANSDYQRYSITSNLDIKASDRVNLGLNLFTRRIDQGAIKTQETSSSAHNQGVIGAAYKFSPTLGIYDEDGNFTRSIVGDPSDNPYALATERESSTQEDRVQPNIYAEVKILEDLKFRSNIGAVISNERRGYYAPRTLLQGESLGGVAELTFRRKSTLLNENYFTFSKQFGGDHNLNIVAGYSYQSFISEYGFSANQTFVNDAGIYWNMGGGTNMVLPSSSLEESVLSSYYGRLNYSYKSKYLLTVTNRYDGSSRFSKNNKWAYFPSAALGWNAHNEAFLQDVSFLSELKLRASYGVTGNQAINPYQTLASLKEVLTTQQGHIVNAVAPATIANNDLTWESTAQVDIGADIGLFEDRIIINTDYYRMVTSDLLFEVPLPEYSGFSTALRNAGEVENRGYELGISSRNIVGAFKWNMDVNFSINRNKILKLSDTVDVFYKNTPGAVLGGENQILRVGEPVGMFYGYVYEGVQQEGEEVLSGGEGVGGEKFKDVNEDGMLTSEDRTIMGNPNPDFIWGFNNTFTFKGFDLNIFFQGSQGNEIANYTRYELDGLIGKSNATAAMKNSWTPENTNTDVPAIKARPARFSSRWIEDGSYIRLKSLAIGYTLPKSWVQKMNMRSFKIYVSGQNLWTATNYSGVDPEVSFRSSGAQDSNRNLGLDFASYPMAKSYTVGLSVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUI1</accession>
    <name>A0A654DUI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="349" mass="40609" checksum="39F3494BC15CDB11" modified="2020-04-22" version="1">MAYQWSAAQAQDIYQKYDIYRSPFRVLANKIGWTVSTGYAATNYKHDLAGFYFYQDGENQLILSKQNELGPVFSGYQHWMSNPTAGEEVNLDDVFDVPYDYLENPVNNPDLRNRQFIGDADTLGLSFSSIASTVPVMASAHYDFQKFRIGLGFQYERHYMTPLKPSVYQEVIRPYEPDFKQTHYIKYFGMMGYEFYEFWDYTFVLEVQLGRAKPGKEINTNAIGIGQNFYTNIGVNIEHNLSEYFRVVIRPSYDIKSYVINLPDASSIRHTNSAFMVQVGISINIPEIPRSPMASDHVQLKHVITDPASGRLMEVRGQPMWKKQNPKVGENHRRLWRYKLKNRRKIDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV36</accession>
    <name>A0A654DV36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025345">
        <property type="entry name" value="DUF4249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14054">
        <property type="entry name" value="DUF4249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024997776" evidence="1">
        <location>
            <begin position="34"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="37183" checksum="8D68EFDB04BC2922" modified="2020-04-22" version="1">MTTVTNRVRRFTQNHILIMKNIFLTLATVFAFACETEITPKLNAPAEIIVVDAWVNQKMEPQKIRITRSQPYFEQSIPKKIPGAHVVIEDLNSGEIYEFQEEAESYFWYPTDQPFGKVGHQYKLTVTVDDQEFEAFSLMGRVPPIDSIIFHYNPKDMIVKKEYYTAEFVASDPAGAGDAYWIKAWKNGAFLGNPGELNMAYDAGFSAGQPVDGQEFIIPIRKDFMNPYDPHPEKANELLPPYEVGDSLYVEIHSLDHLAFDFLYGLYFQIARPGGFAELFSMPLANTSTNIYPVGDEDTPVTGFFNTSAVSSRGLKLSEELAKASMKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA8</accession>
    <name>A0A654DVA8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <shortName evidence="1">HMG aldolase</shortName>
            <ecNumber evidence="1">4.1.1.112</ecNumber>
            <ecNumber evidence="1">4.1.3.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22748"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:58276"/>
            <dbReference type="EC" id="4.1.3.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="1"/>
    <dbReference type="EC" id="4.1.3.17" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010203">
        <property type="entry name" value="RraA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01935">
        <property type="entry name" value="NOT-MenG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="17162" checksum="3B525C3012238C14" modified="2020-04-22" version="1">MTFTTSDLWDVHGDALACAEPVFKSYGMVQSFHGQIVTLKLFEDNSLVRELLKTNGQGKVLCVDGGGSTRCALVGDLLAQLALDNQWSGLIIYGSIRDSAQIGRMPIGIKALNTCPVKSIKRNEGQINIPLNFAGVNFTPGQYVYSDADGIIVSEQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD2</accession>
    <name>A0A654DVD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Por secretion system C-terminal sorting domain-containing protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024827965" evidence="1">
        <location>
            <begin position="20"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="756"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="826" mass="90201" checksum="933EC13E417C008D" modified="2020-04-22" version="1">MLKRSAFLLLTIIGFTVQAQNVDVFGPQPFREILDNEFPINSWTPSAPSAVKNLQYFLLLDAETKSNVVTLSDDNSTLAISSVGDVIHTYGTVLRGVLQIVDINSDTDDDFANKYRMVPLLHSYFALNYSSGSSEVFAVDVGSYYVEEATGSGYLVVEFDGTPDAVILSASGQYTYNGTTGLQEENSSWTRQWFVLDNGKLSLTGDEADATTFFMADARDLIDNIIDDGSDFDPSGIDWQTNPFAAYPEGLWKYEESDFNGSFLMDVDEAYMPQFGDHESTLDAAVEALNEIESTLTTNGESLRYDKEVYLTFRENLLSRTLSLTDIYNGRLNERLVAYVYFTNAADDSGAHHPFMVIASHNISDSPNYLIDVSRPPGDGSGGGYAEQSITRNAVLGYFLIKIPLKDYGVIDQLTDNDLSPYGILADELDTDPSDYDVYNYVGPSSQAIAIDGVVVYPGYNNNLRFAAEDGEITSTGIHVGRGMGLHYHADGHGFNQNGLNLYNLADYEGKNHPPMIGFGYDGLVMFGRYEEGYASMAGYGEALDDYGGHDHDGFGYHYHAFSKSFEAQGPVGGEPIPFTQHFFNVGAWRGNINGIPGFLEVTPQQLKNEDIGRYAGASYESGEPGPGSVEVEACESYVWEGTTYTTSGTYTVTLTNASGGDSLVTLELTIWEEPVVLVTASDGVLMAEEQEGVTYQWYDCEKDASIENQTNSSFTPMGPGSFAVNVSNGPCSVLSACVEVDETILSTEPANGILVYPNPVTTDFRILGISEPTRVTVMSISGQIISQITDINSDTDIPVPKPPGVYLIKIDLGDKVLLKRIITTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI9</accession>
    <name>A0A654DVI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024789073" evidence="1">
        <location>
            <begin position="29"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="203"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="552" mass="59561" checksum="41B39C762D0C3DD5" modified="2020-04-22" version="1">MNKNIQRILSACVIWAFMIILQVGTAQAQVQIQAEADAFVRAGSQSDNNFGTRDYMQAASGEGSNLHEIYLRYDLSQDIPDLELVKSAKLNLVPFGSKWGEDGSTQWVSYVQDDTWDEATITYNTAPGSTQDSVAAVVTTSAGGATLETIHTIDVTDLVKAESDKKLSIKVSSSLLAGTFKAEYHSKEYSEGGTYLEVELYSPKIAFSASKQSLKAGGSVTFTDESQYSPTSWKWTFEGGSPAESTDQNPTVTYAAEGKYDVTLEATNAGGTSSLTQSGYIVVDAEGVSTIKVYAAEDALTRTGSRGDDNYGDKDYLQSASGEGSNLHEIFLKYDLSKDISDLSAIKSATLYMIPYGNKWGEEGSTQWVSYIQDDTWSEATITGNTRPASLDSLSGVQTTSAAGETLESPHAIDITDAVKGETDKILSLKLSTTLQGSTFKAQYNSKEHSNGGSYIEIVVEQPEVVLSSELKANKINVYPNPSSDKVTIVNPDQKIVKVVLYNITGKMVRAQDVPAGASLVEISLEGLTSGNYLIETFDVQGRSKTSRVIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP2</accession>
    <name>A0A654DVP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="380"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="469" mass="52857" checksum="000FA071BBC3B19E" modified="2020-04-22" version="1">MAKDKKKLIVLVVEDNDGDYFLVEDFLQDMILAPEIHRAVNFKEAKSFLSEDHHEVHAILLDLSLPDKTGEQLLREILVISKGIPLIILTGFSGEGFAIKSLALGASDYLLKDDLNATILYKSIVYSIERAKNQISLKESELRYAELFHLSPQPMWVYDIHTLKFIQVNKAACDHYGYTTDEFLAMTIKDIRPPEEVPMLERTVLRRDVLLPYKGVFRHTKKNGEVITVEIKSDILTHNGNNVRLVLVNDISDKKKAQEELLTIAHQVEDRERTRISIDLHDGLQQTLVTSYMHFESIKTALDQLDTEASERFVKGMEVLNEGIEQVRTIAHELMPAKIEKEGYVAAITQLLDQIEGSIQFKFVQNLGGKRLPSNISLILFRISQEAINNIIKHSRATMATMALELEGSIVRLSVVDNGVGFSIDNLAKDHSIFGLKAIGSRIHSLGGLFELDSEIGRGTSLTIEIPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVR4</accession>
    <name>A0A654DVR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyco_hydro_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="202"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1034" mass="116315" checksum="E1FD64443B865CB2" modified="2020-04-22" version="1">MKSQLTTMKLKSIIIVLTLCWSVILSGQTLNLNGEWETGIDRQYTSQTMVPGIPTTNTHNPAPGSVWFKKQIQLPEGDWTNVSLVLKSALYRPRVYINGDKVGESIGGMMPISFGLSHKQVKPGNEIVLEIELTSLKDVPEDDPAKPSPADLWRSCQASWIRDDVSLIFYNNWQITRLIPFISESRTSVNIEWGISPDGKDASVPDQVKFDILDATGAVVLTSKVKPKSLAGSVTIPFNDQLKLWSPLDPNLYQLRTQVIHKGKVAHEKVINYAPKTFGISEDKSKFLLNGNPCTLRGGSIVWNRFAREAVAKDLIDDREWFYEAIIKPFKEHGANLLRFHLYPPPEWMIDLCDEYGLLVQLEAQYFHGMGGSRETLPVYYSKLLTLGAQHPSTALIQLFNETEPELEKIMHDSYLEISSQFPNYLIANSDTYNLHRYWWSMAENVALYANSWKDYDRPTVIDEFGANYMNENWEVSSYPRAEPGFDRFLNVGHTPEMRSKMQEWSYGRIGEYWRRIGIQGIAPFCTLGPFEDGGNWYEGPLEEARLKPLWSSLASAYSPRSVSMEIWDRNFEPNQNIELPLYLFNEYPEGDSVQVELRILNEESASIWSVRLSHWLDPFAEAVKKVNVSMPATGGDYVLEAELLNPVGGVKVPVISRWEVNVHEVVVPSVLKSASIGVPDSELELSAILRDLGLKPGSITDEVDIIVTSHITWDAIYKGDSSVMPQLDGAIRAGKKVVMLDVGPKFHGEKCPTPAPIVGADGTEYPAHIIQKGDTSKNTLLLASQSFSDEFEARREKDIWSGDFPGGVSMSMKYALEPESHFHPSPFGNELWNDLSGKDRTWLWNGLRGGLTVPAIDVFVDDLDQNGYLDFWLKRGADTARIKNAPYYAYELEGYFGFSDTNDDLLVLQDLYKRVHFVVEDLVSLRGLLDPDSDAKIQDISRVYSSLGGKSEKIVPLAIAGYGLNKTPIQMIDFANGGKLIVSNLFTAGRLTKEISGSNLYDYRFDPVCLQFVLNMLAFPLESEESERNSDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW7</accession>
    <name>A0A654DVW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">infC</name>
        <name evidence="8" type="ORF">MARINOS108_10863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="19040" checksum="82DF5AA4F8681015" modified="2020-04-22" version="1">MNEKIRAREVRVVGDNVEVDVYPIEKALELARQQGLDLVEISPKAEPPVCKVIDYSKFKYEQKKKQKEIKAKAQKTVVKEIRFGPNTDEHDFNFKLNHAIKFLKEGAKVKAYVHFVGRTIVFKERGEILLLKFAQAVEDYGKVELLPKLEGKRMSIIIAAKSVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW27</accession>
    <name>A0A654DW27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinol:cytochrome c oxidoreductase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030948">
        <property type="entry name" value="MoCo_extend_TAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04519">
        <property type="entry name" value="MoCo_extend_TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="827"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113238" checksum="3A9E9CB8691D1E3B" modified="2020-04-22" version="1">MKETKKYWKGLEQLQNKAEFQKYANKEFPEYLPISGEDGGEPSRRDFLKLMGFGIAAVSLAACETPVKKAIPYVKKPVAVDPTLPNYYASTYVSGSDYCSVLVKTREGRPIKLEGNKLSTISGGGTTPQVESSVLSLYDQERLTDPKIDGAKVSWADLDSALAKEFAAANGKLTIVSNSIASPSTQATINKLTEKFGGTHVSYDQVSFSGMLSAYESAFGNRMMPYHDFSKAKTLVSFGADFLGAWPNRTANNKQFAAGRKLSKDKTDMSRAYAFESNLSLTGANADYRVAIKPSQEGLYVANLYNAVAAKMGATQVNVAKVDNELLTKAANDLVKTQGASLVMSGSNDINVQLMVIAINDLLGNYGATLDISKSVNLRKGNDAQFADFVNQLNAGSVAGVVFYNCNPVYDHPLGAQIEAGLAKAKFAVSTSDRGDETASLVKYQAPDHHFLESWNDFEPVTGFFSLSQPAIQNIFNTRQAQQSFMTWAGEEGSYYDLVRDTWNSNVFAKANSIEFFNFDAFWNKCLHDGVYEIKSEAQSASADVAVSAVASAIGSSYSLDNTGLELVIYQNSSVADGIQANNPWLQEMPDPITKATWDNYLTVSPKQAEEWGIEIGDMSTQKVNFTANGVTAEIPVLPQPGQAYGTVGLAIGYGRSKAGKVADGVGVNAYQFGTVSKGTVSFAVTTGVSAEPTGTPYRIAQTQTHQTYMGRETVIQETLLKNYQKDNQAGRNFPKIATAEGYKKPYAVSLWKGHEYPNHHWGMMIDLNSCTGCGSCTIACQTENNIPVVGKQEVLNRREMHWIRIDRYYSSDATEGKAMEDPAENPEVTFQPMMCQQCNNAPCETVCPVAATTHSSEGLNQMTYNRCIGTRYCANNCPYKVRRFNWFKYHDNKQFDKNMAMNNDLGKMVLNPDVTVRARGVMEKCTFCVQRIQSGKLEAKRNGRRPEDGEVVSACASACPSEALVFGDMKDPNSRISQMLQIKQNEKSVEAREPRAYHVLEELRVMPNIWYLTKVRNKDEVSKTEKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW59</accession>
    <name>A0A654DW59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11901" checksum="140C85E7DFC6ABA0" modified="2020-04-22" version="1">MKTKGGYVYIIANKNRTVLYTGVTNNLYSRVYEHKTGIGSVFTSKYKCTDLLYFQFYDTIIGAIEQEKRMKKWKRSFKESLINSMNPTWRDLFDEIEDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW70</accession>
    <name>A0A654DW70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="21492" checksum="FFBDF576CA4F447B" modified="2020-04-22" version="1">MEQIIQTSKSYSKWITVVSVAIPVVVAVLLFAPVKLSFENGGWIQLLPTLNAVINSATAVLLLAALAAIKTRRTTLHRNLMMTALGLGTLFLLSYVLYHASTVSTVYGDINHDGVLSEAERAEIGGYRTVYLLTLLSHIALSIVVVPFVLFAFYYALTGQFVKHVRIVKYTFPVWLYVSVTGVIVYLMISPYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ4</accession>
    <name>A0A654DWQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xyloglucan-specific endo-beta-1,4-glucanase BoGH5A</fullName>
            <ecNumber evidence="7">3.2.1.151</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.151" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024956614" evidence="4">
        <location>
            <begin position="25"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="BACON" evidence="6">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="173"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="503" mass="56334" checksum="A2653DC100C09A44" modified="2020-04-22" version="1">MIDFFRYLLLTVKVLLLLQFSACAEKGDPKPDEGEVHLSVDKSSLAFGSDGGVEEINISSNAIWKLEYPSGTWVRASLQSTKGDATVKITVDKNETTEQRQLDFKLSAQEAESINISVTQEASEETTTSEEPELADFVDPDNSGMRNMTSLELSQEMGLGWNLGNSMEAISANNGELSGGETSWGNPVVTKALIDAVKAAGFNTIRIPVSWSHKMEDAETYHISYEWKLRVEEVVNYALDNEMYVLINIHWDGGWMDSPIYDDQDYINDRIAIMWKQIAKFFRNYDDHLLFAGTNEVHMSGEYGEPSAEYAEVQNSFNQTFVNAVRATGGRNSYRHLVVQTYNTNIGYGVRHFSFPADEIGDRLMVEVHFYDPYQFALEENGSTYLWGAENAGNAAHSGWGDQDWIDEAFGDVKTYFVDMGYPVILGEYGAILRTELPNSAYELHIESRNAYLTYVTRAAVSNGMIPVYWDNGYTGNNGFGLFNRNSGEVVYEDALQAIISAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS4</accession>
    <name>A0A654DWS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor SusC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">susC</name>
        <name evidence="8" type="ORF">MARINOS108_11532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024901175" evidence="5">
        <location>
            <begin position="26"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="121"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="395"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="989" mass="108915" checksum="47870BD806035271" modified="2020-04-22" version="1">MKQNLKMMKHLLMVVFLLTCTLARGQDEHIVTGRVTDADTGQGLPGATVVVKGTSVGTITNIDGQYKLELPTGWESITVSFVGFVSQEISVLGKSIIDVSMPTDIAALEEVVVVGYGTVKKSDATGSVAVVSSEDFNKGAVNSVQELMIGKTAGVSITPISGAPGNTSTIRIRGGSSMSASNDPLIVIDGVPLDNTPIGGSPNILSTLNPNDIESFTILKDASATAIYGSRAANGVIIITTKRGDRDLKLTYNVTTSLYTTPKKVEVYSGDEFRTLINEVYAENTAVTSLLGDADTDWQGEIYKNAIGQDHNLSLSGTLKSTPYRISLGYNNTDGVLKTYNFERTTLSLGLDPTFLNDQLKVKINLKGMDNNNNFSDQSAIRNAVVYDPTKEVFNGNTRWRGYTTWTTGGIDGSPINLAPANPVAQLALTDNTSNAKRSIGNIQFDYQLPFLDGLKANLNLGYDISQTKGHNNVKDSTQWVYIPTVAGGRTSPYFNERQNQLLDFYLNYHKVIGDNSLDVLAGYSWSHFWRASEDSTSNASGTASTQRNDFQSEYYLLSFFGRVNYSIAQKYLFTLTLRNDATSRFSPETRWGLFPAAAFAWNVGHESFLRQSHIVSDLKLRLGYGITGQQDLNNGNDYPYVAKYTISDDAARYAFGNQYYNTLRPDGYDADIRWETTTTANVGVDFGFAGNRITGSLDFYLKETKDLLSIVDVPVGTNFSATVLTNVGSMENRGVEMNLNAKVITTDKVNWEVGYNVYYNKNEITKLNLNDDPDYTVPTGSVGGTTSGTIQAQRVGYPVNSFYTYQQLYDQDLNPVEDAFVDRNDDGIINSSDLYIYQNPAADVLMGINSWLNVGNWDFTFVGRLSLGNYVYNNVASNSTYQSLYSSMQYLSNASMLADKTQFMNALNTRFSDYYVENASFFRMDNINLAYNLRDLFGNKLNMKISGGVQNAFVITKYSGLDPEISGGLDNNFFPRTRVFLLGLNCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX56</accession>
    <name>A0A654DX56_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024994188" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="115"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29680" checksum="1DF0C6C2A2545BC2" modified="2020-04-22" version="1">MKTILLFLFILLCPGLNLDCFAQTHTTTWNPSALTPEQKKFIDSCDQYLYDTLGYKLTTSSAPLTYRIMKLDGNYSEYIEIDSAAHTISWKFKKASDDEKMMRKRIVLNRASIHSLIGQKFPDLEMVDLNGNHYTTEQFKNKTVYFNFWFVGCQPCELERTKLNQLYEKYKENPNIQFISLSNSNERKTREHLRRKNLQWPVVILNKSLKSNFSYIEGYPTNIILNNQHFDTALAGLSEGTFLVIDERLETLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX84</accession>
    <name>A0A654DX84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucan 1,4-alpha-glucosidase SusB</fullName>
            <ecNumber evidence="5">3.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">susB</name>
        <name evidence="5" type="ORF">MARINOS108_11533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029483">
        <property type="entry name" value="GH97_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019563">
        <property type="entry name" value="GH97_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029486">
        <property type="entry name" value="GH97_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14509">
        <property type="entry name" value="GH97_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14508">
        <property type="entry name" value="GH97_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10566">
        <property type="entry name" value="Glyco_hydro_97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH97_N" evidence="3">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_97" evidence="2">
        <location>
            <begin position="276"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="GH97_C" evidence="4">
        <location>
            <begin position="555"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="659" mass="74952" checksum="2E01BC5EB147B46E" modified="2020-04-22" version="1">MKIIITGICLLFLLGGCSSDIIISSPSGRLQVIFRINNDVPFYEVKRDGEAVVLESPLGFELQDEPSLTGNFKIVKINEFTLDETWSQPWGEVKNIRNHYNGITITLQEKSDLQRLLKITFKVYDDGLGFRYEFPEQPHLTDFVITDELTGFIMAKNMSAWWIPAYGDEIDSEFLFSNDPLSELSEKVHTPLTMEYEDDLFVSIHEAALVNYPAMTLEPSRQLLSCDLVPWASGIKAEVSAPFNTPWRTIQIAEKVGDLITSYLILNLNEPNRLEDLSYITPGKYNGIWWAMHLNKYTWSQGPNHGAATANVKKYIDFAAENDLSGVLVEGWNEGWDYDWSEGRFEFMRPYPDFDIEELTEYARERGVGLIGHHETGGNIINYERQLPDAFAYYQKYGVHSLKTGYVTRRPNGEHHQGQFMVRHYQRVLEMAAAHQIALDIHEPVKATGLRRTYPNLMTREGARGAEYEAWSAGNPPEHTVILPFTRCLAGPMDYTPGIFDILIPSNPGHRVHTTLAKQLALYVTIYSPWQMAADLPENYIGHPALQFIRDVPTDWEETRVLNAKIGDFITVVRKDRHSDDWYLGSTTDENPKSLPVKLDFLLPGRRYIAEMYADGPSASMEDNPLEISIDRKEVTSTQSIDLNLAPGGGQAIRFHLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX88</accession>
    <name>A0A654DX88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class C beta-lactamase-related serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="521" mass="57964" checksum="0B7976E391150BC3" modified="2020-04-22" version="1">MRKHFAPLFILLIIFTSCNDQKVAENASPNDLPRSTPEAEGISSLAISTLIDSMNQSNLGFHSIMIIRHGQVVAEGWWNPYREELKHSLYSLSKSFTSTAVGLAVQEGLLTVNDPVISFFPNDLPAEVSDRLASMTIKNLLTMNTGHSQGTLNTMRNDSTGNWPKAFLAQPLTHEPGTHFFYNTGATYMLSNIIQQKTGLTVQAYLTPRLFEPLGITGMDWEVDPKGVNVGGYGLRVKTEDIAKLGLLYLNKGEWKGEQLLSADWVEEATSKQVTSQEGDNDWSQGYGYQFWRCKPAGLYRGDGAFGQYCIVMPEQDAVVAITSETFDMQACMTLIWKYLLPEMKPDELDEDPETWNALQSKMKALSLPVPTYSTSSPMTSLLQGKVIALEPNEFDIESLAFTFGVNDVSMDIYRPYGQSTMILGVNEWQSSALDRYNLFERPDQQPIRSVTAGTLGWKDSKTMVINVRYLEMAHGDEITLSFDEDGKVTLSFLGSVAAGRQDGSENRTPITGVIQQQETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA9</accession>
    <name>A0A654DXA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex outermembrane receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025019886" evidence="5">
        <location>
            <begin position="22"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="122"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="326"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="816" mass="89726" checksum="2B6F3DB900B093F7" modified="2020-04-22" version="1">MKKTYTILIASLFFLCFESFAQNVVSGKVIDAKSGEALIGASAILSGTSKGATTNVDGSFEISGVADGSYIIKVSFVGYEELSRSVNVSGADVDLGSIGLAESIFSFDQVVISGSRQPEKITQTPATIEIISSKSLDELPSFNPGELLSRMKGVDYLRAGVVGTGINIRGFNSNFNSKNLQVNDGRFSTLIATGLPMGPLTTQIKEDIEQVEVILGPNAALYGPNAHNGLVHTITKDPRSSAGTTVALGVGNQSMLSARVRHAQVLNDKLSFKVSGEYTKAEEFEFMDSVYIDRNADGVKEGYEEYKLDNDIEFLRAEAALYYSVTDNSDLIFSWGGSNSTYLSPTNVGRNQIKDWKMNYFHLRYVSDKFFAQVYNTTSSTEDTYAIDQRTKNYYAAIDGGATEAEAEESSLGNGATFADDSKRWNAEVQYHDTFGKAKVVVGSQWQRDNANSNGTYLLDNGGKDPIIINQIGVYGQLDYQFTEAFKAVAAFRGDNHEVYGFNFIPKAGLVYSAGNGAFRLTYGKGIATPTILNMYGDLFAGLILGNAEGFTLTDGSKVDKQTVEKIQTFEIGYKGELVPQRFFLDANAYYNISEDFLSPATVVGVATHRGDTPMSEVQSGYGAYGGLVASYVNFGRVDTYGFDIGTNVYLNDKINWTFNYSYFDYSVDEDDLENNDFNKDGVVNKLDILVNAPKHKFGTGLYFRGDKLFGNVYMRWVQEYDYFSSYQIAAKTQDLNWRGTPIRENARSTDTWNYGPLGGFVNVDLGLGYKINDIFQVAGQVTNLFDSEFREFTAAPFTGRLYSIEVKAKLPAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB6</accession>
    <name>A0A654DXB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="20013" checksum="8B6A9B4FF5438FF3" modified="2020-04-22" version="1">MTRVSSIFQRHQLPVLLFFTALCFPWWVTAQKKEPTPRSLAVVRTDGKQQRLVLIPKSMKIGLSSGKKYREVSPVILSDSTLIIEKDTILIHEILFITASVKRPWPVKAAGILISGAGALPATAGLIYLPFAVTYQEYLSPSSAYAMMAVGMGMGVTGYLVGGLKRKFSLQKKWTLEVINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN0</accession>
    <name>A0A654DXN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="34605" checksum="BFB81106BFB730D1" modified="2020-04-22" version="1">MFAKHIDFYRGFQSKFFLNKQKLNENNFNSVSSQTDSEEPKELLNTIRIDSRITYLTSIETLFQLIIALKPSDKYNADERVLINLSKKSFYYKDIRDFSSEKESLFDFLLETYKARNGQLYLKAKHIFYFNLAPESYDELSFIDKSLNSIIDILRTLAADLSDRREYNAYKHGMRIFPVWTKFGIATKDMKNKVEFDLNDSFTLMEYDFETNKTTSITIKSDLKRDFLMTELVTALIDSIIGTRKKYFSKDNSGIYLNDFGQIDISEYSKPNVTSHFMEFSMQPEHSKTKSNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT2</accession>
    <name>A0A654DXT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative metal-dependent HD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_11703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD13941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="408" mass="46864" checksum="D7351AB5F5043998" modified="2020-04-22" version="1">MAGERSELLKEAQQFAENILNNELAPEIKYHSVDHTREVVRAALEIARKTGVSSEELEIVELAAWFHDLGYKRTIENHEEVSAEIALDFLSEKGYDDERAAKVVGCIMATKMPQNPKNDLQAILCDADLAHLAEENYCDKADLLQEELRRLNGKNISDIDWYRSNQRFITEHEFFTGYAKEKFTARVKKNLKKVNEKLMEMKNTEDEVSALKAQVEKLKVKIKKVKEVTPTRGVETMFRLTSKNHLELSAMADTKANIMISVNSIILSVLVSVLFRKLEEYPHLIIPAMLMTVVCLSTIVFAILATLPNVSKGTFTEEDIQNKRTNLLFFGNFHRMEMGKYEWGMKEMMKDADYLYTSLIRDIYFLGVVLGKKYRLLRISYTIFMFGFVVAVLAFGVAEVFFKAPYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY69</accession>
    <name>A0A654DY69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative enzyme</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="126"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="652"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="766" mass="84395" checksum="B59BFA96A30DFEE8" modified="2020-04-22" version="1">MEKDFKRALSITGTIRFEDLKVTPRAEYAAGVPAVAVALKHARMEMGLFRGLKTLAHMNQKDGFDCPGCAWPDPDDRSQLGEYCENGAKALAEEATLKRVDADFFQRYSVEELSKLTDYEIGKSGRLTQPFILDKGSVHYRPISWQEAFDRIGDHLRQLESPDEALFYTSGRSSNEAAFLYGLFARAFGTNNMPDCSNMCHESSGVALTETLGIGKGSVTLEDFGKAEVIMVIGQNPGTNHPRMLSALQQCKENGGKIITVNPIPEAGLVRFKNPQEVKGVLGGGTVLTDIFLQVKINQDVALLKLIMKRLLAMERSGRPVFDQEFIQEKTNGLEALTKDLDSHDESTLLAACGVPSGKVDEAVELLASRQKIIICWAMGLTQHKNGVDNIRECVNLLLLKGSIGKEGAGTCPVRGHSNVQGDRTVGIVHHVSPSFNQALKDTFGFDPPEKPGYDTVHGIQAMHAGKVKVFMGLGGNFVSAASDTAYTAAALQQCDLTVSISTKLNRTHLITGKTAIILPTLGRSEQDVREGVPRYVTVENSMGKVHRSRGRLTPASEQLRSEVDIVCGIARAYFGDKGNIPWKAFSTNYDLIREKIEAVVAGFEAYSKRSEGGGFYLPNNARTGDFSKLPGGKARFSINRLADHGLSQEDFVLMTIRSHDQFNTTIYGLDDRYRGIFNERRVVFMNALDMEKLKLQQEDVVNLVSRYDGVERRASQFKVIAYDIPIGNLAAYFPETNMLVPINHFADKSHTPISKSIVVRVLKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY78</accession>
    <name>A0A654DY78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14679" checksum="C01DC1164A786A6E" modified="2020-04-22" version="1">MNSLDGLKVYSAFFNLTKINRTEYYDKFLNIFQGLPLQDWQNNCDPSGLSIKIIEEPKIISQLLEERKDDQIAHLFGHMLTCEHANSVTEQYLMIWETTQEYPKLQRILNSIYPELVNKAPIVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK4</accession>
    <name>A0A654DYK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system RelE/ParE family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="11724" checksum="73F53F8A8218004F" modified="2020-04-22" version="1">MSKPIEWSPRSKKDFLNLLDYLQDKWGEKTVRKFNDRLQSIIELIAERPEIYPASGKKKQVRRCVIGKQTSLYYQIKKDKIELITLFDNRQNPTRKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL2</accession>
    <name>A0A654DYL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="77" mass="8988" checksum="3F27B3DF6815A204" modified="2020-04-22" version="1">MDLQAEKLSLLEWLAGLNDPKTLKEFISLKKSKEVDWWDEMSEDERAAIDEGLAQLDRGEGIPHEQVMKEVREKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL7</accession>
    <name>A0A654DYL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025250">
        <property type="entry name" value="DUF4199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13858">
        <property type="entry name" value="DUF4199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="20188" checksum="09C1FBDDFF8D98CA" modified="2020-04-22" version="1">MNAQLKKALQFGLISGLVIIISWWITQLIFAPAEGEPYDFSQGEFLGYLTMIVALSAVFLGIKNYRDTTLAGVISFKKAFFMGLYIVLVASGIYVVGWMIYYPNFMPDFMDQYSAYQMQEYTKEGMSAAEIAVKQQEMKEWMELYENPLVMAGFTFLEIFPVGLLISAISAVILKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM6</accession>
    <name>A0A654DYM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="49"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="263"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="509" mass="59109" checksum="D6EEFE748871F13F" modified="2020-04-22" version="1">MKNLKYIFLVVVGLTLYSCDEDLLDVKNPNTLTEDQFWASAEDARLGVNAIYAMQYKPGLWSRWIYFRYDLTSDIGYSKSPWIELADWTRFQYINYNFWEGQVQTWRDHYKAIYRCNQVLANVPDIDMDETEKQLILAQAKFFRGFYYFNIANLWEDAPIVLEPSSPEDLPEKRTQAEIWEQVVTDMTEALAVLPPSWDDANVGRPTKGAAQAFIAKTYMQQHMWNDAKTALDYFFTGEGSGLYSLVPNFKDNFTHLNENNSESVFEIQFSDANFGGGDGEVPNASMGNNRAQFFAPGGIGWSDGQLRHWVVDEFKKELDQDGNLDERLRHSAIYSELEADFGDKTYGRDWQWGPDDAYFRKYQRDYYRDNEDYFSQVNLRLIRYADILLLYAEVLNELGNTAQAYQYVDEVRARANMLPLATAYPAIGVDQDLFLERLKVERVLELCGESTRWMDLKRWGDLNTQARVDAIALRDPDFNNFVVGKSHRLPIPQVDVENNPNLDQHAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYN5</accession>
    <name>A0A654DYN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucan 1,4-alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024876788" evidence="3">
        <location>
            <begin position="27"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="460"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="875" mass="97527" checksum="5071B0EE450B7A62" modified="2020-04-22" version="1">MFFNRPTNTLYLLSLLLIGMGCQPHASYEFPFQNPELTLETRVDDLVSRMTLEEKVSQMVNEAPAIEHLGIPEYNWWNEGLHGVARAGLATVFPQAIGLGATWDERHMLKVATAISDEARAKHHNFVSRGKRNLYQGLTLWSPNINIFRDPRWGRGQETYGEDPYLTGKMAVQFVRGLQGDDPTYLKTVATVKHFAVHNGPEPERHVFNAQSNYRDLWETYLPQFEMAIRQGKAYSAMCAYNRYNDEACCGSSTLMTDILRNEIGFDGYIVSDCGAIEDIFKHHQLVATPEEAAALAVKTGCDLNCGLGEAIFPYLVQAVEKGLIDENTIDTSVKRLFMARFKLGMFDPEENVPFAQIPYSVVDSKVHQALADETARKSMVLLKNEQQTLPLSKDLKKVAVIGPNANQWLMLLGNYNGVPSAPVTPWAGIQQKLPNASVTFAQGCELAEGMPMFYTIPGENLNSLKASFYNNRTLQGDPLYSESWDMLDANWNDRAPREDMDDDNFGVRWEGQLSPSVSGFYQLGFIGTMNTQLYLNDSLVAKTSYHFRDEYGDPRLRKSDQIWLEAEQSYDLKLEAGDSYADATVQLVWAAPKPNLKAEALKAAQYAEVVILCMGLTPRMEGEEMDIQIEGFRGGDRTTLELPQTQKDLIRSIEKLGKPTVLILLNGSALAINWENENIPAILEAWYPGQSAGTAIADILFGDYNPAGRLPVTFYKSADDLPPFEDYNMAGHTYRYFQGDPLYPFGYGLSYTSFEYGDLTVSEGNTTDQAVSVLVKVTNTGKVAGEEVVQVYLSNLSTQLPTPAHSLQGFERVSLEPGESKFIRFVLPPAAFRVIDDQNQKVVLPGEYQLSVGGGQPGVTLQTSNILSKTINLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS5</accession>
    <name>A0A654DYS5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_110009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="22138" checksum="D84E4EF4D219D106" modified="2020-04-22" version="1">MFDLSSYEKLPQSFYNHSDVVHVAKELLGKYVFTNIDGIITAGKIVETEAYCGRNDRACHAHAGRTERTRVMFEKGGVAYVYLCYGIHHLFNVVSNEEGLADAVLIRAVEPVLGMETMHIRRGSKVPFSKLTAGPGTLSKALGIQKKHNALDLCGDTPEELEIEATTRVGVGYAGEDALLPWRFYIRDHPFVSVKKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY7</accession>
    <name>A0A654DYY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="403" mass="46396" checksum="C2F97DF98F84099F" modified="2020-04-22" version="1">MKKWILMIGLALTSALTSQGQGQLEYLSAPITDGEYMIVQMTEDFLSDHKFGSPWLRDLDFRVRSSGSQIGVEEYRMRLGLINPLEIKANRDYKRLMDRQLGAERLEVINNVMLRRYEILLEHAFLSRKKNLLESRENELQKQSNLLLGAQGSLNDLIDVEESLTKLGLESIGLDHKIELVMSSVSSSGVRNLEWGSFDVIPIDTIWQRTREIEWSNGMLHDRALRSLAQKEQLLKIDQAEAFSNIGFIQGEYDLDRGDAPADHLGFQMGLTIPIFNSDKPQLERKKLALIDDEVELETSVSMEKERVDFMISEMETSYLQLMLLAKRSQKLNEYRQLNSAISGDLDTYIKLSELEYFIREKTLNYESAIRMNYIRLLHLKGKLAESPLINYLSADEVSFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE1</accession>
    <name>A0A654DZE1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="15381" checksum="A6285BA01FB5EA51" modified="2020-04-22" version="1">MSIAKANDTVKVHYTGKLTSGQVFDSSLERDPLQFTVGGGQMIKGFDEAVNGMAISEKKTVTIPSAEAYGDRNDELIQKVPRTELPADMKPEAGQTLVATNDNGQQTHVIVQEVTEEAITIDANHPLAGQDLIFEIELVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE2</accession>
    <name>A0A654DZE2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobA</name>
        <name evidence="7" type="ORF">MARINOS108_12091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="26858" checksum="D7761AEE60B4FA21" modified="2020-04-22" version="1">MTKTPKLTLVGAGPGDPELITVKGVKALQKADVVLYDALVDPELLSYAPDAVHIPVGKRAGKSSVSQDTINHLIVQYAKEMGHVVRLKGGDPFVFARGCEEKAIAERHGIEVDVVLGISSVMLPGYFGIPLTCRGVNQSFTVVTATTSEGTLSEDVLRAAEHSPTTLFFMGLGKIDLIARAYVEFGRGDLPAAIISKGSHADGDVIKGKAKDIAAIAAKAKPEAPALLIFGEGAAQASNQQQVNTWWEAAKSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK4</accession>
    <name>A0A654DZK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="60" mass="7000" checksum="79B4ADCD55250EE6" modified="2020-04-22" version="1">MNVLVVIIALFIPNNADFESKITYQNTYKSHIPNMTSEQFNQMMGTVQEYYIKGININLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN4</accession>
    <name>A0A654DZN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="5110" checksum="9526D5A01FE6BE54" modified="2020-04-22" version="1">MTSQSPKIDLELTNEKFVKHRISFLEVALSLLIAFMVLLMIYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX3</accession>
    <name>A0A654DZX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase-C39 like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_C39_2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="27181" checksum="176162C094328D50" modified="2020-04-22" version="1">MIKNPELDARTLSLDIHAQPNDETCGPTCLQAVYQYFNDPMPLDTVISEVKTLKSGGTLAVMLGNHALARGYQATLYTYNLHMFDPTWFSSGVDIRAKLEEQKIYKTAKGFHVAANAYLKFLKLGGEIKFEELNTKLIKRLLNENKPILTGLSATYLYNCSREIGAINEYHDVKGEPTGHFVVVYGYDPVNRVAHIADPLEANPISDTQHYRVSLQRLINSILLGIVTYDANLLILSPKHNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E056</accession>
    <name>A0A654E056_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="401" mass="45728" checksum="6663D1564A3EC6A0" modified="2020-04-22" version="1">MIQLLSILFLAGLAYLLQPGATLRLVYWSGLVFRLCCGLALGWFYLVHLGAGDTVYFHEQATALFQLSIDSFSEYTRSLLTAQHPVYMGEARNEFFVKILSILYLITGGNYWMSGLYLSFAGFYGSWYLVTRIHQHHPRYFLAAVVAFLFLPTAMFWSSGVLKDPIVNGALCMLAGFCIRYWHQTTNRLREYFLVGSGLLVLFYLKFYLVAIAALFMGVLAWAKVLNALVSRKTYKLLLTLGWIVLMGALVTQVNKNLHFDQLPSAVYNTHQIIYSDSDPDKTLHFPDLEPTYTSLIQHLPKGFIAGLFRPFMWEVRGPLMVGAIQSLVFLLLFFYSLFHSHRYRFTALSWIAVGYIAALATFLPLVSPNLGSLERYKAAYLPFLLFILLIIPVKRFLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0K6</accession>
    <name>A0A654E0K6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rplV</name>
        <name evidence="10" type="ORF">MARINOS108_120493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="17747" checksum="96DE09C890296A38" modified="2020-04-22" version="1">METAEKKVKKSVRIRLQKEAIKKHKEENAGKLGAVKSSLKNVPTSPRKMRLIADMIRGQKVNVALNLLKFDNKHASLTMEKLLMTAIADWQASNGDVNIEDAELVVKEVFVDGGRMLKRLRPAPQGRAHRIRKRSNHITIIVSDVNESNQSEEKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0P3</accession>
    <name>A0A654E0P3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">MARINOS108_120224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="28834" checksum="36B7AB68B97E7C3F" modified="2020-04-22" version="1">MKQVTPKKHLGQHFLKDENIARKIVNGLDPGKMSTLIEVGPGTGVLTKYLLDEFPDFIAFDVDTESVAYLKDHFPEHATKFLHQDFLKYNLAEMNGPIGVIGNFPYNISSQLFFKIWDHRDTVNEVVCMIQKEVADRIVSKEGNKTYGILSVLLQAFYDIEYLFTVPPQVFNPPPKVQSAVIRLTRNETARLECDEALFKRVVKAGFGKRRKTLRNALKDLNLDFATDTEVFGQRAEQLSVSEFIQLTKYISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S0</accession>
    <name>A0A654E0S0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_130009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000005">
        <property type="protein sequence ID" value="VXD17344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045829">
        <property type="entry name" value="PKD_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19408">
        <property type="entry name" value="PKD_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024970194" description="PKD domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="734"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1074" mass="113639" checksum="28AE26BA85FBBD2D" modified="2020-04-22" version="1">MKYLFSFGLTICSFIILAQQRPFVNNIDKTSGTVGETVSISGSGFSPGNMQVNFGSGIAVITNTTTTLIEVTVPSSATYGPVLVLDKSTGLSGASSQVFTPSFSGSGFEVTSVGSQFDFTTGQQYTYDLCACDFDGDGLKDVAVANNTGTSVSIFKNASTLTTPSFTRTNIANGFSTISTECGDLNGDGLPDLVFTSNQEIISIYTNNSTAGTISFTRNQFILPKQNDGNIRNPKRFKIIDIDGDGKNDLVVGNETDNIIFIYRNISTGAIITFDTPVSITVTGAVHASGLDAGDINGNGLNDIVTISAAQNDFVYVLQNESSPGVIKMSQQVLSNTSTRLNVILADLNMDGKKEIVTTSSVSDEIDIFLNSSTINSVSFEATPITISNTQDAWGLEAADLDGDGLTDLAVTSTSGGISILENTTTGGTLSFDVKTISTNGGNRNITVFDINGDAKPDFATTNRSDATSFGNLTVLLNQNCLAPTIGPSDLTFCVGNAFTLSATRSLQTTYNWSVSAGDATINTNGSRTTSVTVNSGTSATIQVTITANDGSCNDVGTQTFTLTGGTPPPAPSIINSTSGVICAGDPFTLTATANRDEYLWTLPDGTETTRTTNTLEIASASSVNAGIYQLRVLQAGSCVSEVGSISVSVDEPPTVGIFNNGADDFCETTTVELEVPSYSGFGFQWKRNGTDISGANSNTFVASLSGDYTVAVISDASGCDKESSAYTLNAVTLPVSNFSSVDEICVGVAIDFNVTSTGQNGFDLQYEWDFGDGTTDDQPTTTHTYNTPGTYDVTLSTSYETVESCADDFTKTITISDIPEVDIILPEGSEKCPLDSLRLELPQNYISYNWSTGDTSYFTYAKTAANEEDVTITVDMVTNLGCEVQSEVTVSNYANSRVGITTSEATIVDDTVNLADGASTISLKAQNGSSYNWEPSEILDNTTSETVTAYPRERYTTISLTGPDAVNGCETTATLVIETPGVIARKTFSPNGDGLGYDCWEILNTNSLEGCTVYIVDQRGAYVFKGSSPFQDNCVWNGNLNNGSTQVPEGIYYFIMKCDNSRYNMTGSILLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T3</accession>
    <name>A0A654E0T3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_120264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="319"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="803" mass="91056" checksum="58C84450BDCEB610" modified="2020-04-22" version="1">MFWNYLKVTYRSFLRQKVYSLINITGLAIGLACFILIFLYIRDEMSYDRFHSKSDRTYRVIEHFESEGIGEHSASQPFPTGPTLVNDFGRQIVHQVRLFNFQSPSLALAYREKDKAFNESRIFFADSTFFDVFDFELKTGDKQTALDEPNSILLTEEMARKYFDDEDPMGKVLEFQGNQHLQVTGILANAPRNAHFQFDFIGSFSTLKQSFGGNYPRTWYWNPCWTYVVLEEGVGKEEMEAFFPDFVQKYFPKFVVDDITLELQPLEDIHLHSRLDYEIQANSTAENLKIFGLVAIFVLLIAAINFINLSTARASKRAKEVGVRKSLGSEKRQLVRQFVFESVLLTFFAVIIALVFVWLAIPAFNELTEKSISIASLVNPLDVGGLLGLTLLVGVLSGFYPAFVLSSFNTVLVLKNAYQKVSGFNFRRVLVTIQFAISIMLIIGTIVAVSQLQLLQNDDLGFDKEHVMMIPVIRSPMGQHYESFKNAALQSTLIRSVTAVEEIVGSKHQVNNYQFEGMDQSKPFPHFHVRHDFSETMELEMVAGRDFSYEVQTDDSLALIVNETLVRSMQWGTPEEALNKRYYFGGELRGKVIGVVKDYNFVSKHHPIAPLVITLNTFPGAFNLFIKYVAVKVDGNNTEQAIADLEAAWRGVMPTRPFDYFFLDDRLNDSYKAERKLSTVTLIFSGLAIVVACLGLFGLATYSVEQRKKEIGVRKVLGISSMQILMLLSREFVLLIGVAFVVAIPLAYLLLDAWLNGFAFRVSIAAWPFILSGVVVFVVAMLTIGFHAYRATLINPSDTLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E164</accession>
    <name>A0A654E164_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="38252" checksum="9F77093B0AD65778" modified="2020-04-22" version="1">MWEFCFYLLQKYHLMKSIPELQELLDKGIAGLDFGHEPRNLYEPISYIMSLGGKRMRPLLTLLGYQLGKGDCERIVRPALAVEVFHNFTLMHDDIMDEAPLRRGEPTVHEKWNNTVAILSGDTMLVKAYDLLLELDPALLPEALRLFNQCAVEVCEGQQIDMNFESEERVSVEEYIGMIRLKTAVLLGFSLEYGALMAGMPVEVRKQLYDVGVKMGIGFQLMDDLLDVYADQAKFGKQVGGDIISNKKTFLLIKAQELAVGDQKARLSNWLSMREFDPAEKVTAVTKIYDELGIKALTTQLMNQYFDESFTLLDSLAADAEGKSLLRGFAGQLMKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E182</accession>
    <name>A0A654E182_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="170" mass="19121" checksum="006416D260580F34" modified="2020-04-22" version="1">MSEPYNNWERFYHRFNLIFHGIIAGSLLPFAFVFLETQKEFPDAPLIEGMESMVIKMLLVVLAGVLIFLAQSYRKTVISEVQALSDIKEKLDLYLSKKLIQYGILAGAAVAGLLGLYLTKDQLFSFVFVVVLFVFSLVRPTFDRVSAEIGVGSKDLQEWGRGSVESDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B1</accession>
    <name>A0A654E1B1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001769">
        <property type="entry name" value="Gingipain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029031">
        <property type="entry name" value="Gingipain_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01364">
        <property type="entry name" value="Peptidase_C25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_C25" evidence="2">
        <location>
            <begin position="403"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1665" mass="184110" checksum="A82EB8540E7E8079" modified="2020-04-22" version="1">MWWTRVFLLGGCILLGLTVNAQTFGNEWINYEQSYYKIKIAKDGVYKVTADELAIAGVPVANIAVNRYQLFRRGEEVAIATQDTNNDGRLDSFEFYGKKSDGKADTELYVSPEAQPHTYYNLFSDTATYFLTWHLTNTSGKRMEFSSIKDATGLTATPYHTDSQLKLQVGTYATGLRYGSTNEILSARYDYGEGWTGSNISKNASNTFNYTLSNVETTGPKPVLELVLIGVSSFEHVVDIRVGRNTNNLRTLATVTFDARYHKYYSGALEWSDVGTSGELMVQVTPKGLSGQTDVISVSYVKVDYAQKFNHTSGAKTYNIGSTGAQRGYVKVPTSVASSLRVFDITNPVAPKSLATTAFADRLEFVFPDLTIDRVLHAFEAPAAVPSISKATLTPLAVTSANYLLVTHPKLDQLVDGMNPVTAYVNYRKSSAGGGYDVLKVEISSLFDQFNYGDPSPLAIRNFVGYALNSGAPQYLFLIGKGTTVNHKYYRNNPQTTSLTHYVPTFGYPGSDLLFSVDTQAGNLAPQVATGRLNALNSGDVKAYLDKVMEMEAVPYDQLWRKNLIHLSGGQTAGELRSFENYILNFKSIAERDFLGGKASNINKNSTDAVKVINVAQEVNQGVSLITFFGHSSSIVTDIEIGRASNPADGYTNKGKYPVILVNGCNAGEIFTTSLTFGEDWMRTPNAGALAVMANSDFALSSSLKRWSDLFYQFAFATDETFGRSLGELTKLVSERFLEVYGTGGTEQSQVYQTVLQGDPAVKVFGAQSPDYEIQTLETYASAFGQERVLSNADSFQINIPVRNYGRSVKDSLKITIQRTFPDGSQETVSRYFERVLRQDTLSFTLYNDLESSNEGTNTFLIQLDPDNDVTELNEGNNTSNFELFIPKGNTIPLYPVDYSIIAEPVTRLLWQSANQLEQNRVYSLMVDTTATYNSPFLKNESLEGGLLMSYPLDLTSAPDSTTVYWRTRFSEARDNEDTSWVESSFTLVDDAAEGWAQVGAYQFEKDPLHGVSYDVNSKKLSFQETKTGIQINTHGVDSPNEYVDYQVIVDGINLLLTDNAADPTCKRLNAINAVVFDKESAQPYRPFGFLGTDVYDDLVCGRLPQMIHNFNESQVLGSTRYLDSIVSVIDNGDVVLLFSFDYVAFSKWDAQIKSSLNNIGIANATIEGLTDGQPVIFLGRKGDPVGSAVVVTSDGSAVPLKSQAIELVGLVTGKFTSGSLSSTLIGPAKRWQSFHYEVDGEPNDSWQFSVTGVSPTGQKDLIFSGSRSTEIDVSELDADLYPYMTLNFAFADDADQTPPNLRSWGVNYEYPAEGILVPEDYEIKEVAEGAGFSRNYLFTNISNAVFTDSLNVQVAVTNVTSGNRESENYRVAAPAPGDTTRIEVIKNTRGRTGYNNVLVSVQASETELYTVNNMVNQLNALLVTEDKINPVLDVTFDGGYILDGDIVSPTPSILIRFKDDNEFLYKDDTSGITIELKSPCEACDYERVSFANPKVTYTPASESEDFEINYMPGPLEDGVYALRVQGTDESGNQSGEYPYEISFEVINESTITHFYPYPNPFSTQTRFVFTLTGSTMPDRIKIQIMTVTGRVVREITQDEIGPLRIGNNITQYAWDGRDEYGDQLANGVYLYKVFIRQNGEQIEHRNTNADRAFKHGFGKLYILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N7</accession>
    <name>A0A654E1N7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024832919" evidence="1">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="30271" checksum="094C42F217FD2053" modified="2020-04-22" version="1">MKTKVLIYTLLLQLSMSCLAQEWTHVKTIKLKNEITAQSVDTDGKIYLGTMAGDMLRYDQDGNETELYSAVGNFPVTLISAWNRFKVFLFFKSPQQFIFLDRFSTSPITYSLADYQRPLVTLCAPGIDNSVWALSADYNELRKYNIQNSNVLLSNPLQINLSNASYMQAYQNLVLISDTQQGLHFFDQYGNLQFSHPEKGVSYFQVINDQLVFLAGAWITTIDVFRPGNITKIKAPLGGFNNVLKWGDRYYFIGKDQVLIYQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E237</accession>
    <name>A0A654E237_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">MARINOS108_20255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="573"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="743"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1119" mass="127993" checksum="9F0CBB6BD7C61E9C" modified="2020-04-22" version="1">MEAKEILNFYTRSELIKSISEAVSTQKTIRLKGMAGSYDALVGAATSSINQKTNIYILHDKEEAAYFINDLRNFIAEDHLLLFPSSYKKPYQFEETENANILQRAEVLNRINSNKNKGLQIVTYPDALYEKVINKRSLLENTFKASVGEKVDVEFLTELLSSYDFERSDFVYEAGQFSVRGGIIDVFSFAHDYPYRLELFGDEIESIREFDPESQLSTHSLKEVTLIPNVQTKLLKEERQPFFDFIPKDSIIWMKDYRETLDLVEKGFNKAVESFQGIMKSGGYTQVVFSPEDLFDSEKTFSKLLDNYNRVEFGHRFYLKPDREFDLGIKPQPHFHKNFNLLAEDLFSFQLKNYEKVITAESPKQLERLETIFLEINSDLTFNGVGASLKEGFIDDHHEFVCYTDHQIFDRFHQYRAKEKFSKSKSLTLRELKTLQAGDYVVHIDYGVGRFAGLDTVDVGGNKQEVLRLVYRDDDLLYVSIHSLHKISKYSSKDSTAPSINKLGTQDWENKKKKVKKKVKDIAKDLIELYAKRKAAPGFAYPGDDYLQAELESSFLYQDTPDQALSTADVKKDMEQNHPMDRLVCGDVGFGKTEIAVRAAFKAVNSGKQVAVLVPTTILAMQHYHTFSGRLEDFPVTVDYINRFKSTKEINDIKKKLKAGQIDILIGTHRIVNKDMDFKDLGLMIIDEEQKFGVKVKERLKEMRVNVDALTLTATPIPRTLHFSLMGARDLSIISTPPPNRRPVTTEIHEFDEEIIRDAVSHELRRGGQVFLVHNRVSDIEHIGNIVYRLVPEARIGIAHGQMDGKQLEKVMLKFINAEYDVLVSTNIIESGLDIPNANTIIINRAHMFGLSDLHQMRGRVGRSNTKAYCFLLTPPTSTLSSDARKRLTTLEEFSELGDGFKVAMRDLDIRGAGNLLGSEQSGFINDMGFEVYHKILDEAVAELKETDFKSLFENEPDRKKLQAIKEDCIIETDLEILIPDQYVSNISERLNLYSRVDSIRSEEELTEFVTSLKDRFGPLPEQVKNLITSIEVRWNAIGLGFEKVTVKNETMKCVVSENKDESYFQSDLFGHVLSFIQSQPRRCSMKDHKKKLIISIKDVTDINEALQVLNHMKSPVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E278</accession>
    <name>A0A654E278_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="18322" checksum="2BC6333CA29DD30B" modified="2020-04-22" version="1">MKREDTVDYNIKVAWHAISRMYNQYGAPFDVTASTGFVLLNIDVELGTPATKIAPLMGLEARSLTRMLKTMEEKKWIYREQDPNDGRSVRIFLTDLGKEKREFSRKAVKEFNTKLRELVPEQDIRTFIEVTRSVTQLIDDKNLFDKLAEAFIYETNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D8</accession>
    <name>A0A654E2D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recF</name>
        <name evidence="9" type="ORF">MARINOS108_20355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="366" mass="42538" checksum="0ED9B31E0889C479" modified="2020-04-22" version="1">MKLNSLKLSQFKNYQEVKISFSEGINCILGKNGMGKTNLLDAIHYLSMTRSALNSIDQQNISHGEKYFAINSEFTLQDKPVVINCYFEQGKKKVFKVDGKEMEKLSEHIGNVPSVLILPDDTEIIKEGSEVRRKFFDSVISQHDRAYLELLMNMQRLLKQRNSFLKSNDGNLKINHNLINVYDEALLPIFRSIVEKRTAFIEHFSPFFSENYALIFEGEEIPDITYKSEVTEDHFEESYKKGLQKDIILQRTNKGAHKDDYAFKLNERPIKKFGSQGQQKSFIIALKLAEYDYLKAQKGFEPLLLLDDIFDKLDDDRIERLITLLTDSERFSQIFMTDARAERSRAFFKDHDDRISFYDISNGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E3</accession>
    <name>A0A654E2E3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="61"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="44092" checksum="FAA64105E2E7DD5D" modified="2020-04-22" version="1">MLLRSGLIGAITFCIVCFLGCQSGDKPKGTVSVPGEDAWTFVSIPDFLNVDTEYPQPGWEESLGMILNEVKSENPDFVLVPGDLVMGHWDAPSWQSADSIAKYSGLYYSAWKARMQAHELKFYVAIGDHEIGDNPWIDSAKVAVIPAYKEAFATHLQMPQNGPAHMRGTAYWWRHKNVLFVSVDVFEEGESDEGSIKPGVSGEQLAWLESVLLENRDARHKIIMGHTPVLGPVRRWSTSGLKVAEGRQSGFWQTMSKHEVDLYLCGEMHAITCTSRDGVMQVVHGGLIGYNRRTSYLMVRVTDDQLYLTLKELEMYPSGDHLWQTGDNRPLENLSVGTDGFDVVGKVVMDKSRGRSLLEPKGYFKKKFEKSDEWAAAVFREGVSTEMTKISLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H4</accession>
    <name>A0A654E2H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">prfC</name>
        <name evidence="7" type="ORF">MARINOS108_20066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="526" mass="59840" checksum="32E9229C213181AD" modified="2020-04-22" version="1">MTLEQEIQKRRTFGIIAHPDAGKTTLTEKLLLFGGAIQTAGAVKSNKIDVGTRSDWMEIEKQRGISVATSVMGFDYKDLKINILDTPGHEDFAEDTYRTLTAVDSVIMVIDCVKGVERQTEKLMEVCRMRNTPVLCFINKLDREGRDAFELLDEIEEKLGINVRPMSWPIGMGKSLRGVFNIFENNLNLYEPSKTKKVTDVVEIKGIDDPELDKRLPASAVKTLREEIELVNGVYDPLDVQKYLNGEVAPVFFGSAVNNFGVRELLDCFIQIAPPPVARETEERKIEPNERKFSGFIFKIHANMDPKHRNRIAFARICSGTFHRGTSYYNVRHDKQFRFSNATAFMAQQKETVDEAFPGDIVGLYDTGNLKIGDTLTEGEKGLYKGIPSFSPELFREVINLDAMKSKQLEKGLNQLMDEGVAQLFTFEMGARKVVGTVGALQFEVLQYRLLNEYNAKARFDHVNIYKACWISSKNEAKLDAFIKDKYRHIAKDKEGKLVFMAESKAWLQMVQDNFPEVEFHFISEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L4</accession>
    <name>A0A654E2L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_12038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="280" mass="31731" checksum="AFE9ED0E841EA055" modified="2020-04-22" version="1">MESSSVQIVKYSGETTPFDIDKLRQSLLDAGATESATTRISRKIADELYDGISTKQIYQRAHRLLRNHAQSKASRYGLKKAILNMGPTGYPFELFVGELMKAQGFKVKVGTVMPGKCVTHEVDVYAENEKMVRMMECKFHNRLGYKTDVKVTMYIKSRFEDLESVWKNDAQISHKKHEGWVVTNARFTKDAIDFGTCSRLQLLSWDYPAQGSLKSLVTRHRLYPITTIGVLSKSNKELLMKKGIVLAKTLWEQPEALEGLGLESSKIDKILTEARTICDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q1</accession>
    <name>A0A654E2Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase/(4S)-4-hydroxy-2-oxoglutarate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="223" mass="24275" checksum="5A9E2FE8F55DD6CF" modified="2020-04-22" version="1">MARFTRIEVALKMKETGIVPVFYHKDVEVCKEVLKACYEGGVRVFEFTNRGDYAHEVFAALNKYAEKETPEMILGVGSIVEAGTTSLYIQLGANFIVSPVLNPEMAKVCNRRKISWSPGCGSVTEISYAEELGSEVVKIFPGSQVGGPSFVKGVKGPFPWCSIMPTGGVEPTEENLSKWFEAGVHCVGMGSQLITKEILQNKDYAALQASVSQAVALAKRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V2</accession>
    <name>A0A654E2V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation factor SUA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23180" checksum="C55F1E9A6FABA9A4" modified="2020-04-22" version="1">MSAELIKLYPENPEEKKVRHIVDVLRNGGLVIYPTDTVYGIGCDIFNSRALDRLKMLKGIKGKDLNLSFICYDLSQLSEYARHVETPVFKLMKKCFPGPYTFILESSSKVPKILNAKKKTVGIRVPDNNIPRDIVKILGNPIITTSIHDEDEIVEYSTDPSLIYEEFEGLVDVIIDGGPGGNQPSTVIDCTGAAPVVIRHGMGDIAQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E302</accession>
    <name>A0A654E302_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">prmA</name>
        <name evidence="3" type="ORF">MARINOS108_20291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="30941" checksum="62FE3D61059B8426" modified="2020-04-22" version="1">MSFITLNITCSEEKRELLIAELSLFPFDAFEETETGLLISCEEADWEEEPVFAVLARYEVECRVERVEKVNWNEEWEKNYDPVIVEDQCIVRATFHEPRPDFPYEIIITPKMSFGTGHHATTYQVLKHQLQLDHKGKKVLDVGCGTGALAIMAHKRGATDITAVDIDEWCIENSEENFSLNGCDHVKLSLGGIETVQEKDPFDIILANINKNVLLDQIGAYSRRLKSKGTLVLSGFYTEDIADLMAEAGKFGLVHQEQTERNRWAMLALKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E326</accession>
    <name>A0A654E326_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_140145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="326" mass="36793" checksum="D969C1287198F94A" modified="2020-04-22" version="1">MELYPLKFKTIFKDKIWGGQKIKTILGKDFSPLPNCGETWELSGVQGNISEVANGALTGQLLTEVIAAAGDALLGRRIRREYGEEFPLLIKFIDANDDLSIQVHPDNELAQKRHNSKGKTEMWYIMQADPGATLISGFSQDLDRASYQKAFDEGRLNEILNREEAQAGDVFFLPAGRVHTIGKGLLLAEIQQTSDVTYRIYDFDRRDAEGNLRELHIEESLDAIDYKKYDQYKTPYKDQADTRVDIVSCEYFTTNKLTLTGDFELDHSGLDCFKIYICLEGNAKLIYPGGVENLQMGEVILVPAALEKYKFETSGGVTMLESYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3E1</accession>
    <name>A0A654E3E1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ruvB</name>
        <name evidence="8" type="ORF">MARINOS108_20094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="55"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="341" mass="37862" checksum="A8C72074E5E4BBEC" modified="2020-04-22" version="1">MREDYLRGDDEQMDSGEKEFEKALRPLSFDDFAGQDKVVENLKIFVKAAKLRSEPLDHVLLHGPPGLGKTTLSHIIANELGAGIKVTSGPVLDKASELAGLLTNLEAHDVLFIDEIHRLNPVVEEYLYSAMEDYRIDILLDSGPNARSVQISLEPFTLIGATTRSGLLTSPLRARFGINSRLEYYDAKLLTSIVGRSADILETPIDQEAAYEIARRSRGTPRISNNLLRRTRDFAQIKGDGAITLDIAKMALKALDVDDHGLDEMDNRILATIIEKFKGGPVGLSTIATACGEEAETIEEVYEPFLIMEGYIKRTSRGRQATERAYQHLGHIPPQEMGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F0</accession>
    <name>A0A654E3F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025019461" evidence="1">
        <location>
            <begin position="30"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="37488" checksum="67FEF197EBA451DC" modified="2020-04-22" version="1">MHFSKKFIDMKKIILTVAILAMICGSALAQSVTEKEVKISGYGEKKLKKAPRKVYIANFRVYFHVIASATAKSTGGSTIGGGSYKGSTSTTMTVAVDGVDVPDFQKVTDDTYNRFVADLKSKGFEIISTAEASKIEFYEDWEIKEGGQVNYANVPGYVSVTPTGTQYMVKKETRKGREKSTFIDRTPRISKELEDAIVIEATFAFPFIEMKTNSSNMVGFSSVKAKTNFELGSAAGSDGLANLFENSQVKFTAGSGPGAAADAYLAADLKKPIALEGVFKDEKFKEFSAAKSTPAYYGIVFVTNTKDQVTNTAACDQQKYVEATTKAINGYIDLALEAFYDNAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H2</accession>
    <name>A0A654E3H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA-protein-cysteine methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="12337" checksum="AAE77FF3B78BB693" modified="2020-04-22" version="1">MEDSKSNFFGDVYEVVKLIPRGRVTSYGAIANYLGVKGSARMVGWAMNQAHGNHSVPAHRVVNRAGSLTGKHFFSGGPEAMQQLLEAEGIVVKDDKIIDFKSIFWDPATELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K1</accession>
    <name>A0A654E3K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="1">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="153" mass="17554" checksum="34ADEEFFD0BDE3F6" modified="2020-04-22" version="1">MKKWIKRIAYFLLLGLIIIQFFPGEKPAVSTDNPGDIHNEVLVNPEVSGILKAACYDCHSNETKYPWYASVAPVSWLVIHDTNEGRDELNFSEWATYSAKRKHHKLEEVIEMVEEGEMPLAVYNITHPEGRLTEAQIEVLISWAKARMEEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S8</accession>
    <name>A0A654E3S8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="684"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="791" mass="86245" checksum="C287F2B4EDA0838B" modified="2020-04-22" version="1">MNKFYTLSLLILLGCGTENQESTYSDLNKNGKMDLYENPKASLDERVADIMPRLSLEEKVGLVVGMGMNIPGMSMAERKDKVQGAAGSTLELPSLGISSIVLADGPAGLRIDPVRDSLDNNTYYCTAFPIATVLASTWNPDLVNRVGQAMGNEVKEYGVDVLLAPAMNIHRSPLAGRNFEYFSEDPVLSGKMAAAIVNGVESNGVGTSVKHFVANNQETNRMQINTIVSERAIREIYLRGFEIAVKEAQPWTIMSAYNQLNGTYASQNGELLNTVLREEWGFEGLVMTDWFAGKDAVAQMKAGNDLLMPGRPDQRQAILAAVSDGVLNEAVLDENVRHILKIVLQSPSFSRYAYSDQPNLKANAELAREAAAEGVVLLKNDGALPLKDSSIKIAAFGNGSYDFIAGGSGSGDVNEAYTVSLVEGLGRAKYLVSGALREDYQKYIAQEKAKQPEKKFFFELLPPIAERPLQKAEIAAHASESDLALITIGRNSGEFQDRTLDGDYYLTDAEKELIRNVSAAYHAIDKKVVLVLNIGNVIETASWRDQVDAIVLAWQGGQEAGNALADVLIGAVNPSGKLPTTFPMAYEDILSTKNFPGKALPGAEEVMMGPMSLGKASEVVYEEGIYVGYRYFTTFGVKTAYPFGYGLSYTSFSYDGLALGSEFFQERMFVSVEVINTGDTQGKESVQLYITAPGTSMDKPALELKAFSKTRVLKPGEREALNFSLDARDLASFDSDRSAWVVEPGEYSVKIGASSEDIRAEAKFQVVEEIIVEKVNKVLVPNRAIQEITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U9</accession>
    <name>A0A654E3U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="64"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="322" mass="35884" checksum="D0A8798729830AA5" modified="2020-04-22" version="1">MEYLEVTKDIYKQAAITPDVGLCCTTTPIGAFPGLEIPKIMQQMNYGCGSTVHPRDLINDPRILYVGVGGGMELLQFAYFSRQRGGVIGVDIVDEMLEASRKNFKIAEQENPWFQENFVDLRKGDALNLPVEDSTIDVAAQNCLFNIFHEEDLKKALEEMYRVLKPHGRLVLSDPVSESSMPEALKNDPKLRGLCLSGALPLKDYIKLITDAGFGTIEIRAKRPYRILDSKNYDTSETIFIESVEVCAIKDPMPADGPCVFTGKTAIYFGDQEYFDDHNGHVMTPNQPLAVCDKTAQNLAALKRDDIYLSESTYHYDGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X8</accession>
    <name>A0A654E3X8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="24932" checksum="9171DCCE9F7E7002" modified="2020-04-22" version="1">MNLSNSLQFLHALAANNSKEWMDANRSWYQECRQEFIAFVGELIQQMQAFDPGLAGIQAKDTIFRINRDIRFSNDKRPYKTNFGAAISEGGKHSANPSYYLHVQPGENFIGGGIYMPQAEVLKKIRQEVDYNPEELKKIVSEPNFRKVYGEIRGEKLKTAPKGYPKDHPNIEFLKLKSYVVLHELSDAEVTSDRLIEDAVSYFKAMKPFNDYLTVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E418</accession>
    <name>A0A654E418_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="180"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="47440" checksum="D418DA64F4CBC8F0" modified="2020-04-22" version="1">MPNRSVAPEATAVARPNLPQPKEIMLGNIPLTVVNLGLQPLVLFEIAVPVGRWEEPSPGLAFYLFKMLTEGTKSKSSEQIAEAFDFFGSHLEVIPTLDGVSIKLYTLNKFFPALLELLVEMLTESVFPEGEFNTLKQIRIEQVRQQHAKNNAFANLKFREMLFGKEHPYGLLMDVEMVEKVTYQDLLHFKNALLTAPRLFISGLVTDEEIGAIEQFFGNVAFHASQPVNNHPLETTRYLEVTREDSTQASIRLGKVMIDRTHPDIHLLKITNELLGGFFGSRLMKNIREKKGLTYGIHSSLVHLQNASYWTISSEILREKTELAHQEILKEISRLKSETPTAEEFKMVVNYMKGKFLNSFDSPFSSHEMIKGLKQAGLTEQYFYNFLDTLDTVQPENLCEMATQYFGEDDLIFLKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E427</accession>
    <name>A0A654E427_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="29359" checksum="4BB20C62BF9032CB" modified="2020-04-22" version="1">MIKGLYKELLIVIGAFLIGWLAFTLFRWVPDAPELSVSVETEQELGDLLADQVLREYEAVENDTVSEAILTIKKRLLTAIGPTNYDYQLHVLNEPEVNAFATLGGHIFIFSGIIRLSENPEELAAVLAHEMGHVEERHVVNKILKDLGINVVFSILTGSDPVLVGEIAKATISSSFDRTQETSADQFALKTLEEAAISPRYVSTIFRRLKEKYGEGDDRLDFLMSHPNLNKRIKEALEYPLKENFEAEPMNIDWELVKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E441</accession>
    <name>A0A654E441_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="493" mass="56654" checksum="2BD7149666DFFA87" modified="2020-04-22" version="1">MTPLDMNKIAFLLLIFSLSFTASGQIKLSLVDVIDLAKEQSPSAKAAETRKKNLYWQYRSFKSDYNPSLNLTGNLPGYNRDFFQVSQDDGTFAYRSREQLSSSLNLGLIQPIAATGGEISINSNLNQFNDLNANSTTINPIYNTTLFNIQLVQPVFGFNQLKWDKRTEPLRYEESKRSYVEEMEFISLQSTNLYFDYMDAQINLQIAEFNLANNDTIFNIEQGRYNIGTTSKDKLLQVELQLLRSKQDVAQANLDLQTSRLALRRYIGVQDSTASKLELLLPEELPEFSIALDKALAYAKRNRADYIEFERRRAEADRDVASARARRFQSNLVASFGLNNAAGDLPQTYNSPNDQQRVNLTLSVPILDWGRSKSRVQTALANQELTQYTLDQEIQNFEQEIITLVSRMDVIRLQVEITKKSDEVAQERYEVAQNRYLIGKIDITNLNIALTEKDNARRSYIGALRSFWAAYFDLRRLTLYDFMNDELLYQELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E489</accession>
    <name>A0A654E489_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024796547" evidence="2">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="26675" checksum="39447D445B2047E7" modified="2020-04-22" version="1">MKLLTTLFFLTFTMVNTVFAQIQLKEKLSKKANQEIDKFLFGDKNKNQSDDTNTNTDDEVLDTYEPSDSSDPLGGYRRESVNYGTMSPSEVVGFRDLINFLPDELGDYRIAEKPEGSTTRYGEYRYSFGSKSYSKGDEELKASIFDYAQTASLLGLYANQYEHESTDGVMRSIEVNGNPGWYSANYDSNETNLALVVNGRFLITISGNGLEEATLKRYAAGMDLDQLPEAPPAPEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4D9</accession>
    <name>A0A654E4D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative redox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="405" mass="44375" checksum="EE6C5467F65B1F26" modified="2020-04-22" version="1">MRSQKVSFVNKSGQNLSGRMDFPLTGKPKAFVLFAHCFTCSSTLKALDHISSALTQNGMAVLRFDFTGLGQSGGEFEDTNFSSNLSDLTEAYDFLEKKFEAPQILIGHSLGGAAVLHVAGALKKVKAVVTIGAPSNPTHVKALLKGGEKEIREKGEAEVNIGGRPFKIKKQFLEDLEKDRKGEVIRQLGKALLVMHSPQDKIVGIDNAAEIYQQAMHPKSFITLDGSDHLLSRKADSHYVGNMVSSWASRYIVPNDAEEVAPEGEVWTRLSNQGFLTEITAGKHHLLADEPEGSGGTDHGPSPYGYLLSALGACTAMTLRMYADYKKIDLKEVKVKLTHDKVHQQDGGQAEAAKGKIDQIRRMIRLEGDLTDAERKRLIEIADRCPVHKTLEGKPQIITEEATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F0</accession>
    <name>A0A654E4F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="20926" checksum="95995C0EC1D86343" modified="2020-04-22" version="1">MRGKVTFREEQYFKYTWSWWVLLICTLIMVGGILYAFYIQLYLGEPFGAHPASDTGLLIIGVSTSVLMIGLMWLFQFMKLTVEIDEGSIRYSFFPFIRSFRSLQKWDVRKVVVRKYHPIAEYGGWGYRFRFRSGRALTVSGKWGLQLELANGKQLLLGTQKPDQMQEVVDRLKQNWGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I4</accession>
    <name>A0A654E4I4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">obg</name>
        <name evidence="8" type="ORF">MARINOS108_20726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="162"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="308"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="35702" checksum="2231C99A018E3958" modified="2020-04-22" version="1">MDSNFIDYVKLYARSGDGGAGSVHFRREKFVPKGGPDGGDGGRGGHIILRGNKQMWTLIHLKYRKHIKAEHGGNGEGGKRFGLGGSDIYLDVPVGTVAKDSETGEVLLEIMEDGHEQILLPGGMGGQGNAHFATPTNQAPRHAQPGIPGVEKWIILELKILADVGLVGFPNAGKSTLLSVISAAKPEIADYPFTTLVPNLGVVPYRDERSFVVADIPGIIEGAADGKGLGIRFLRHIERNSMLLFMIPTDAKDIKAEYNILLGELEKYNPELLDKQRLLAITKSDLLDEELLAEMEAELPDLPYVYISSVTGLGIQELKDKIWQMLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K4</accession>
    <name>A0A654E4K4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_60081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="445" mass="50585" checksum="5378BD566A25544A" modified="2020-04-22" version="1">MAKTTIKDKKIFVLDTSVILYAHDSILNFAEHDVGIPITVLEELDTFKKGNDTKNFEAREFTRLLDKLAEGKMLQNWNPLNGKSKGQFKVLMEMNSEVDAHKVFGERKNDHSILNAALTLKQNEKKRQVILISKDINLRLKAKSLDLPAEDYETGKIKNVSTLHTGKYEVDVSSDSIDHLFRMGSIDRKEVLGRKKGIANSYYILKSEKNSVLSHYNAVEKTIDKVDKMPIYGVKPRNAEQTFAIHAMLNPDIKLVSINGVAGTGKTLLALASALEQRRNFKQIYLARPIVPLSNKDIGYLPGDIKSKLNPYMEPLWDNLKFIQNQFKESDKEFRNITEMVNQEKLMITPLAYIRGRSLSNIFFIVDEAQNLTPHEIKTIITRAGENTKIIFTGDIYQIDTPYLDSQSNGLSYLIDRIQGHPMYAHITLEKGERSELANLANELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K9</accession>
    <name>A0A654E4K9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
            <shortName evidence="3">DAP epimerase</shortName>
            <ecNumber evidence="3">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">dapF</name>
        <name evidence="4" type="ORF">MARINOS108_20820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="28450" checksum="FF8EC3A1859DF579" modified="2020-04-22" version="1">MKISFHKYQGTGNDFVMIDDRNETFPAENTALISFLCDRRMGVGADGVILIQNHPEHDFRMIYFNPDGSKSLCGNGSRCAIAFAKTLGIIGNQTVFETTDGVHDAFIEGEIVHFHLHDVGQAAKQDSDWFINTGSPHHVRLVTDLDQMDIIQPGREIRYSKHYEPAGTNVNFVETTPEGIRVRTYERGVENETLSCGTGVTACALVAGMIDYQSPVKIETKGGSLTVSFTKTEAKSFQDIYLAGPAKKVFEGIVEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P4</accession>
    <name>A0A654E4P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="18206" checksum="05284FAE4A0B8E81" modified="2020-04-22" version="1">MKIFRYIPIIILSLLSIQSFGQMAISFEEAKNQGINVAELDSTYKSGIHSDPNLAVFSEQQTEYIQAYYAMIRDLSTYLNSNDFRWGGQTRCFNRIYFAADGSIEYFIYQFEEGELSVERQAEFDQLLNEFINSAKFPMSKDVKFAQCSPVNYRDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q8</accession>
    <name>A0A654E4Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ligand-binding sensor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="2">
        <location>
            <begin position="688"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="864" mass="98502" checksum="F48397DAA3315F01" modified="2020-04-22" version="1">MITKKFTLFVLGFVTILTTLYSGPRDFSMLVYNADRDFNGVFIYTIIQDEDGFLWVGGDDGLYRFDGKQMLNLNAKDSAINNLVTASVVSSDGHLFMGYYEGGISIVEHGRYRKIVSKEDLPNKVNRLRSHGEKTIWGLTQNKGLIRVQEDSVTHFSHSIFDQLISYDFMVYQDFIYVATNEGFLELKVEGDQLTSLGFLESTKGLQINSIFQDDHVKNLVWLGTNDGLYSHFLESRDIKPVEGFPAHVQVSSIAKDDLNTLWVGTKNHGLVEVDLNGIEVTAITFFNKQNGFESNQVGEVYVDHENEIWVGTFGRGLVQLNRAYFHHYELYKPLAVQGIHSIANYREDELILATEQGLVHAYHKAMRDSLIFEPLKYTQDYSFTSILVDGEVVWAGTRDGVIKVNLLQKTIERIGLAPKDVMEHHLIREIVKDNDGNLWISAAGNGVYHIKPSGELINLYNTRLGFYHNEIFAIFPDQAGNVWFGSHATGLALLPKGGEMQFLSKDEIFPAFDINTITQSADGNIWITTEGSGIYRFDGENFKQFTAKDGLLSNYCNAAVVDDIGQIWVGHRLGISLIQPGYDLIRTFHHPGELGETEAELNSVCKDRHGNIFFGNPYGVTKVNLPHFNFKIAKRHTHIKDLRLFYNATDLLNYSGKAKLDDILPSDLTFPYDENHITFDFVSINLRNPEAIYYQYMLVGFDKGWSPVEKSNYATYTNLDPGTYTFRVRESDHEALWDDEYTAITFNVNYPYWEMWWFYLLQIAAITLIVWLTYFLSGRLQNQFAIRLMVYISVFIAFEYVHTELEPYLTTVSGETPIFQVAVNLVLALCLLPIEIRLTHYLKLRAQAVEAKKELSTTNQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E546</accession>
    <name>A0A654E546_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="24252" checksum="9F2677CA8B971F70" modified="2020-04-22" version="1">MSKNVLITGAAGNLGSAVSKKLISEGYSVIGTIVPGHRAPENGVDFYECDLTDEKATQAFFQTLTKKYQKMDAVIMLVGGFAMGNIQEASSADMMKMLTLNYFTAFHSAQNAINWMNEATGGKLIFVGAKPAVEGGGAAVLPYAISKSAVIKLAEIINEDKNNKNIQASVIIPSIIDTPPNREGMPDANFDNWVKPEEIAENIAFLISDKANVLRDTVLKIYNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E591</accession>
    <name>A0A654E591_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">MARINOS108_20996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="409" mass="45535" checksum="65FA5E85D104CBF0" modified="2020-04-22" version="1">MAQVTCSFCGRNKKDVDLMISGIHAHICDKCISQAQQILNEELKTKSSAESPKFNLIKPTDMKRHLDEFVIGQDEAKKYISVAVYNHYKRLMQADSKDDVVIEKSNIVMVGQTGTGKTYLARTLAKVLQVPFCIADATVLTEAGYVGEDVESILTRLLQAANYEVEAAERGIVYIDELDKIARKSDNPSITRDVSGEGVQQALLKLLEGTSVNVPPQGGRKHPDQKMITVNTENILFICGGAFDGIERHIANRLNTRPIGFANADDFSTESVDKDNLLKYITALDLKSFGLIPELIGRLPVLTHLDPLDGVALKKILTEPKNALIKQYEKLFEMEDVKLTMTPEALDYIVEKAVEFKLGARGLRSICEAIITDAMFEIPSSKDVKEMEVTKDYAEEKFEKSKFNKLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B2</accession>
    <name>A0A654E5B2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="99" mass="11574" checksum="44575DC6F05F8BB7" modified="2020-04-22" version="1">MVKGGCIYIMTNGNNTTLYVGVTSDLVNRIYEHKNHKYPRSFTARYNLNKLVYYESLPTITEAIDREKQIKGGSRKKKMDLISSLNPDWIDLYPKILEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Q1</accession>
    <name>A0A654E5Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="352" mass="41267" checksum="10E931344EF8911A" modified="2020-04-22" version="1">MKQIRKHRTVLFHILFWVGYFSFNSVRWGHYFGDYIYSIKSNLVEFPIHIILVYFNLYWLVPRLLSKKKYLFYVLSLFGATLAFSLVKILLTYGLVTTNIWPESAKPETDLFGLSYIITVFIGELYIIGLTAAIKLTIDHIRERDAQRELEKNSLETELAYLKSQIQPHFFFNTLNSLYALTLEKSDLAPNTILKLSNLMSFVIYRAKADEVTLMETVTHMKNYIELEKIRFGIRLQVDFEITGKLDDKKIPPLILSPFVENSMKHGGESPEGTFDIWIKLNVEEDKLHFQVHNWLKDYQDSKEVQRLNKSEGIGLQNTIRRLKLLYQNKYQLDISQDGQKHMVNLVLPLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5T0</accession>
    <name>A0A654E5T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation/acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019899">
        <property type="entry name" value="Na/solute_symporter_VC_2705"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03648">
        <property type="entry name" value="Na_symport_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="561" mass="60329" checksum="F0C797069589029F" modified="2020-04-22" version="1">MDVQSWTFLIVGITFALYIGIAIWARAASTNDFYVAGGGVSPLANGMATAADWMSAASFISMAGLISFMGYDGSVYLMGWTGGYVLLALLLAPYLRKFGKFTVPDFIGDRYYSNVARTVAVICAIIVSFTYVAGQMRGVGVVFSRFLEVPVNVGVYIGMGIVFFYAVLGGMKGVTYTQVAQFCVLIFAFMVPAIFISFQLTGNYIPQLGFGSQVADGTYLLDKLDNLHKELGFAEYTGGTKSMIDVFAITFALMVGTAGLPHVIVRFFTVPKVRDARLSAGWALIFIAILYTTAPAIAAFARTNLIETVSNQEYEQVPQWFSNWESTGLIAFEDKNGDGKIQYVAGEKNELTIDRDIMVLANPEIANLPNWVIALVAAGGLAAALSTAAGLLLVISASISHDLIKKQLKPNLSDKEELIWARVGALGAVLVAGYFGINPPGFVAAVVALAFGLAAASFFPAIILGIFDKRMNKEGAIAGMVVGILLMLFYMIKFKFDGFGGGTQADWWFGISPEGFGTIAMLVNFAVSFGISRFYPAPPADVQEMVEQIRYPRGAGGATHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5U7</accession>
    <name>A0A654E5U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Noncanonical pyrimidine nucleotidase, YjjG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="26652" checksum="1221E3E4511EA308" modified="2020-04-22" version="1">MKFTHIFFDLDHTLWDYDLNARKVLSDLYQQFELQREIVFGPERFTEVFFKTNDTLWQQYNQGNIDRDEIRTQRFRKVMAKCGAPDFEKTEEMSEYFLFNCPRQKATIADATMILDYLSKRYHLSVVTNGFDDVQSIKLEACGLDKYFSHVFTSETTGHKKPSREIFDHAVKEVNAHVSTTLMIGDNHSTDIIGARNAGITPLLYNPKGLVKSDCQLQIKTLSELMRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5X6</accession>
    <name>A0A654E5X6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tellurite resistance protein TehA-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021280">
        <property type="entry name" value="DUF2723"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11028">
        <property type="entry name" value="DUF2723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="862"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="988" mass="112944" checksum="8B9123C4196E3881" modified="2020-04-22" version="1">MMGYQKTNVIAGWATFIISMVVYTLTVEPTASFWDCGEFIACSYKLEVPHPPGAPFFLLVGRLFSLLALGDVTQVAFWINMLSVMSSAFSILFLFWSITHLVKRVLKIKKGEETTEQTILIMSAGLVGALSCTFSDSFWFSAVEAEVYGMSAFFTAFVFWAILKWENIENDSDGNKWLILIAYMMGLSIGVHLLNLVTIPAMGLIIYFKNNEKITKKGIILTLGAAGAAILIVMLGVIPGLPSVAGTLEIFFVNGLGLPFGSGVIFFGTAFLGGLVYGIYYSIKKQKLTLNTILLCFTFIIIGYSSYTIVLIRSNYNPPIDENNPEDVLSFVSYLKREQYGSRPLFKGQYYTADIVDQKQGSPTYMRGEDKYEIKDYKLEYVYNPKHTTILPRMYSNTEAHKQRYREITGLQPDEKPSFTDNIYFMLNYQVGTMYMRYFLWNFSGRSSDIQDAGWVGLNGAFDTDLPESLLENKGRNIYYSLPLLLGLLGIFIQYKKDKKYFSVTLLLFFLTGIALVLYLNSPPSEPRERDYIYSGSYYVFAIWIGFGVLAIYDLLGAIVKNKKLLAVLSLLLGLTIPGVMAKENWDDHDRSNRYFSVDAAKNYLDSCAPNAILFTGGDNDTFPLWYVQEVEGYRTDVRVIVLSYFNTDWYVSQMMRPAYESAPLPFSLSLKNYQQGGLNDYLPVMENKSIKGAINANRFLDLIKQEHKGLQVPLSTGSYYNSVPSRQMFLNIDTAKIKAMGVVPKNLENRIVDKMTWSIQGRGLEKNDLGVIDLMVNSNWERPIYFNTTSMNSLNMNLRPYVVQEGIAYRLLPVKNPNAQEYQVNNDVMYQNLMEKYHWRQLDNPDVYYSEDYRNFCLNHRSAFNTLAISLMEANDYDRAKEVLVRCLEVMPNESIPFDYFNVQQVGLLLEVGENDLANYVAETTSKDAVEMLDYYIERGIYNRAEIQQKLYSLNNITRAYRANRMNEEAAKYEEMFNKYYKSFQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E602</accession>
    <name>A0A654E602_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">His Kinase A (Phospho-acceptor) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="311"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="530" mass="59340" checksum="FD0A95B9FE839E30" modified="2020-04-22" version="1">MRRILSTTIWNSSRAFASPVILIGFLVLVSWILDIEFIKRPIPGLVAMNPATAICFILSGLALWLLTSNSARNHSEQYKYGLMLTGLVLIIATVKIVGVLLEVDSHVDTLLFYERLENDLVGNISNRMAPNTALAFLLASIALFILNYTTRGNHVPAQFIAMSIGMVGILSILGYLYQVKVFYGFLKHLPMAINTAVSFLLLSLGILFAKPHKGLMAEFTSDYSGAKTARILIPAAICIPALLGFLRLYSAWKMSISIELGSALLILSIIIVFLVLIWLSTRMLNREDALRKEAEEETQKVNQQLEAFSYSVAHDMRAPLRAVNGYAQMLKEDYENILDDEGKRIIGMITTSSVQMGRLIDDLLAFSRLGRKEIQKTEVDLNKLVVNVLSQVQKSTPHQAKVVVKKLHSVYGDYTLLHQVVYNLVANAVKYSSKRETPQINISTKTKDKSLIFKIKDNGAGFDMKYADKLFGVFQRLHMPHEFEGTGVGLAIVHRIITRHNGEIWAKGQVDQGATFYFSLPLNHNQYERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E633</accession>
    <name>A0A654E633_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024826539" evidence="1">
        <location>
            <begin position="22"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="537" mass="56245" checksum="45016E6EEDECDE63" modified="2020-04-22" version="1">MIIKIGLLTISYLALTGVLWAQCPTSGTISSNCTTIGNLTISGTTLNVDPGVTVTVMGTLKVESGGTLNGTGATFNVWTLADGAGSTNTYNGGTYNVSTSFSTANGGDFAMYNSNVVLSMGTVSISGDDVVLENSTFTGVSSWTTSVTSMAMTGTDITTSGSLQLENATITDAVLDVGTSISLKNTTVTNSIVNSGGKMTIENGSVVFDNSTLDLGTSNLMSFGTTALDFNGNGVLTMNNNTQVDIKGDIVNNEWYIDNSHVRATGNFDNAGNEILVVRNNGTFNLLRNFDNRGNSDVSADSGGFIDVGGNFDNRNGGAVDVNGGTLVVGGTFTGNTPTGDTGDCSGGSGGCCGSSCNPLPVSLLLFEGVERAGKVVLSWETVSELNNSHFTLERSRDGQTFEEIIKVEGAGSCKEMRRYEVTDEQGHNAWTVTYYRLSQTDYDGTHEVLKVIALGSTAFSSEIKTYPNPAFSESIFAVDGATADMSWGLYTISGLQISTGNFSVEQKISTAGMKPGTYLLKVQNLNGYSTKRLAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E650</accession>
    <name>A0A654E650_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamD (BamD/ComL family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="865" mass="97778" checksum="ADBFCE7BBE5E1097" modified="2020-04-22" version="1">MAKKILIIVLLTAHFGATLWAGPLEKLQKLMEKGDYEKAEKVARKSLEKERVNPGSRYYMSLLFLEERYHLYQVDSAYAYITNALSDLGVATAEVREELMEAGLDSSRFVAQRQQVELAAFARTESEMSIAAFEQYLAKFPEAVKKGRAIFMRDSLAFGQASEQDTWQAYERFFEEYPQSTFVPDARSRYQSLIFKDYTKDDKLESYIKFLEDHPDTPFRKMAEEIIFERRTILNQWSDYSWFVKTYPASHLRKKAVDMLYYLGAPDSLQRLASLHPQPDSLRSIAGVQDKLLLPFLEGNKFGLMDLKGVTIIPPAYHEISEDYICGGITSDWLQVRADKTTAVVNRLGQVIVSDVEDIKEISAAVRIVYRDGEGFLYHSSGYQISGLTVDDAQELSNGWIAFKHNYEWGLITPGGYLLAKPGYTSIASQGSFILFESDGLFAISDVSEVAQGISSGLSFVYDDYEMIGDSLVQVFREDQESLIGRNLEVLVPLAAHQIYFDGSFWYVKDSEGYYLLDEFHKRKAPVFAEIEVNDGWLAFRKPDAWMLLSRLGQESVDLLTGLDSVKLLSQHAAYVQRGDQGQLLFQNGLTRTLGAGDGIRVIGPQARESKASYLLLSQAKKQSVIGASGDVILEKQLDEVALLTDSLFRVKKGKKIGLMNTKGKEVLPFKYEVIDEKNGLVFLLQDGKIGCLDLNNGVLLPSEYETRIQTFGQYYEVKKGGKVGLVNGANKWMLPAEFDQLLKWNDTTCWVRSGTIWSLRTFENEVVMDAIRSVRPWFSVDGQSLAIVVGEDGHGLMTDTRGILLPMQYNDILNLGTKEAPLFFAEQHLKTAAFFVVTYFDLAGAPIRSQAFRPEEYERIYCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E661</accession>
    <name>A0A654E661_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025043549" evidence="1">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="56"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="286" mass="31785" checksum="2AA4DEC43CC00ACC" modified="2020-04-22" version="1">MTYKRRTFLKTTAVASAAIAAMPSLMASVVKPSTKIGVQLYTVRNEMSSDPKGTLEKIARIGYQKLEGAGYDAGKIYGFSGKEFGSIVSDLGMELTSGHMSSQVFAEGFDQALEFMVDAGQQYAVFPWLSPEQRVSLDQYKGYAATLSKCAEKAKSAGITVCYHNHDFEFQELDGELPMNILLSETDPEMVKIELDLYWITRAGLDPIQFFKDNSGRVPMWHVKDIANTPERGFAEVGTGTIDFQSIFAEKKTSGMKHFFVEQDQSENPLKSIELSYKNLTEKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E671</accession>
    <name>A0A654E671_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mdh</name>
        <name evidence="7" type="ORF">MARINOS108_90144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01763">
        <property type="entry name" value="MalateDH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="6">
        <location>
            <begin position="147"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="32042" checksum="40162D07573BD165" modified="2020-04-22" version="1">MKVTVVGAGAVGASCAEYIAIKDFASEVVLIDIKEGFAEGKAMDLMQTASLNSFDTKITGTTNDYTKTANSDVAVITSGIPRKPGMTREELISTNAGIVKFVAESLIKHSPNVIIIVVSNPMDTMTYLAHKATGLPKNRIIGMGGALDSARFKYRLAEALDCPASDVDGMVIGGHSDTGMIPLTRLATRNSVPVSAFLSADKLETVSEETKVGGATLTKLLGTSAWYAPGAAVSAMVQAIACDTKKMFPCSCLLEGEYGLSDICIGAPAIIGKNGIEQIVEIELDATEKAKLTESADAVRKTNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6C4</accession>
    <name>A0A654E6C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_60090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="170"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD20912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="29951" checksum="9C69BA312EDD94F2" modified="2020-04-22" version="1">MMRITPMVKNILIINVGIFLIQAILSLPLSQIFGLRVVFADDFVPYQFVTYMWIHGGFGHILGNMFAVFIFGPMLEQVWGSKRFLTFYLICGIGAGVLYGAADYVENISLKNDTEAYLDNPNPEAFSMFIVEHKSYHYNLPRLAEFSDDYYKNADNVAYQQQAIEIVKDIFSSITNVPMVGASGAVFGILMAFGMLFPNTQLFLLFPPIPIKAKYLVLFYGLYELYSEFSRTSGDNVAHLAHLGGMLIAYILLKIWQKDNGRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6F4</accession>
    <name>A0A654E6F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4926" checksum="9CED18FA6F7BEC33" modified="2020-04-22" version="1">MGWQLASRAIANTMHRFFMIIGSVNLKLDDFEKYRKKIYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6I0</accession>
    <name>A0A654E6I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="219" mass="23559" checksum="BD9194895A13D1B2" modified="2020-04-22" version="1">MVLTAILISGSFLYAQDDPDESSAGGTFDPGDLLIEITGTPFSGSSLLDFGSFRARYAVTDVIVPRLGFGMTVNTTQSTPDVVTNLNEFEVRPGCEYHLRVDGSFRSYAALDVILGGRVASRESTTGSSVSGSTQIPSGTNYGFSDTYRGHFRYGVAVGAGAEYHLSSKFYIGAEIGFQFYNDKKNEVSVDGEVYQGTVTNSHASVNTQNTIRIGFKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E821</accession>
    <name>A0A654E821_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsP</name>
        <name evidence="5" type="ORF">MARINOS108_20828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="228" mass="24571" checksum="4206A2B6DCFAA284" modified="2020-04-22" version="1">MPVKIRLSRRGRKKQAMYDVVVADSRAPRDGKFIEKIGTYNPNTDPASISLNDEKAFDWVMKGAQPTDTVKAMLSYRGIMMKKHLQIGVLKGAITQEDADKKFEIWLAEKEAKIQGKVEKLSATKASEAKARLAAEKKVSDARAEAIAAKKKVADDTLVAEIAEAGADEAEKALEEEGNEAVAAVETPAAEEAPAAEAPAEEAPKAEEPKAEAPEEAAPAADEEKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE24</accession>
    <name>A0A654EE24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="25763" checksum="ADBF9E0C077B9B15" modified="2020-04-22" version="1">MNTHFIGHYEHADHSSDEQLWDLFRSGDQEAFSKIYDAHVDGLYNYGMNFTKDSFLVKEVIQDLFVTIWSTRGQLGQTSNIRFYLMRALRRKISVFHKDQKKWESDASEDKFGLAQLLSKKSFEQFNKSNVSEKEVAEKLKLAMERLPLRQREALYHIYYEDLSYEEVAALMNVNIKTVYNLAWRGIEGLRKNLSKVSIFYVSPILAISALKLSADLLENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE58</accession>
    <name>A0A654EE58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4632" checksum="9335FB76BBB4AE39" modified="2020-04-22" version="1">MIVKNVRIYCERYKNGHKHGDSFGIVKGNSVSLARLNVTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EF51</accession>
    <name>A0A654EF51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="458" mass="51620" checksum="4B797685379A76B8" modified="2020-04-22" version="1">MKPTIAIAGATGFIGRWFIASYAHKYNIVALSRNDMEPPAGEGVVWKKVDLYSVRSTTEAIRGADYALYLVHSMQPSTRLNQSHFEDTDLLLADNFSRAAETVGLKQIIFMGGILPKDESQLSTHLRSRYEVELTLGSRSAALTALRAGIIVGPGGSSFEIIEKLVTRLPVMLCPEWTKSETQPVALADVLEVIDYCFGNAKAYDEAIEIGTTEQNTYMGMLRTTAKMLGKRRFIRSVPVFSLGLSKLWVAVFSDSSTTFVSPLIESLRHKMTVEEHPLINALGLKYKTFEEAVEFTLKNADKVPQLPKSLPGIRAKNTVRSVQRLSNPGVKSAEWVAKAYLTWLPDAFRYLIKVNEEADLVSFQLFGRVLLKLRYATERSDEERQVFYIVGGLLAGKEGYGWLEFRSVLEGRYIVAAIHEFVPRLPWYLYVNSQALLHLWVMNRFGKFLSRQQRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSH1</accession>
    <name>A0A654DSH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytTR family two component transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="26236" checksum="9CEFC74A0EF5B8D0" modified="2020-04-22" version="1">MERLTCIAIDDDMVALKIVSSLVEKTDFLKLVGTYQNSIKGAAAIVELKPDIVFLDVQMPDLTGMEILASLQSKPQVILVTSQEKFAVKAFEFDVADYLVKPIENFGRFLKAVTKAKSNIDDKEPISSDSKNLFVKSESLLINLNLKEILYVEAYGDYVKIHTKERTHVVYGKLKDTEESLPESEFVRVHRSFIVRIDKIKNIDQGNLQIEDKIIPVSASYRSHLLESIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT15</accession>
    <name>A0A654DT15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24468" checksum="D458A1887303F82C" modified="2020-04-22" version="1">MSNETEDLVHQILGRSEIEPQLAEEILSIGRLKKVKAGGVVIGPDSTGNEMPIVLEGLLKVMRQDQTGGEVFLYFLEGGETCAMSITCCIEGKKKAFHVVAEEDSVLWMIPMTYIDSWVVKYKSFRKFVFDAYQTRFDEMLNTIDSVVFLKMDQRLYKYLLDKKQASGTFVINKTHEQIANELNTSRVVVSRLLKQLEREGKIEQYRNRIEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT43</accession>
    <name>A0A654DT43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="28477" checksum="78BFD73F01DC88A4" modified="2020-04-22" version="1">MGINPGISTDYSRNIVGACEVVYFMRKILIILLIVTAGQGAYAQVKGFVGLKGGGHLSTAYIEHTIYNTFMNTGFIPGYQGGLMLKLFTNRSSTSFLNAGLQSGLAYEQKGWKQTFATDEPTYHIKMSYLNFPVEAMAYAGKGNTKFFFTLGMFTEWLVNVEKDPDPNPDNMGTGVEFYTYEENRDRTFGYGVRLSLGVQHEFPFGAIHLDGFISYSVSSLMKTEDLDNRLPDLSNHYLAGFTVAYMIPFGKMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT91</accession>
    <name>A0A654DT91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21670" checksum="8F1FBA91E1043D14" modified="2020-04-22" version="1">MLARGALSPLHGRYDQQYDLRLVFVLATLTNFQIALACDCKEQGGLKEAQKSNYEDSELIFMGRVIELNDDGTFKFEILETFKGSERKYIELKQTHLCSILPSEDEEYWLVYIDDLKNKESAITSSCGLSRSFRYPYLMNVNDLPPPPPSTDAFLQLESEIMMSEHRTKSLEILKGEIEQLRKWKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS7</accession>
    <name>A0A654DTS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="102" mass="11670" checksum="D7C54932E008D365" modified="2020-04-22" version="1">MTHWLIILTNETCFSLRYKEVHKSTLPHPCASSRFIAFVRTSLTSITHFLHRTARVARYSIPQNCIPYRATLAFPNAHPNAGKAVFVSRSVLFRKNISARVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW4</accession>
    <name>A0A654DUW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="46032" checksum="581B249520EFA639" modified="2020-04-22" version="1">MKKTALHSEEVSRLRAEIEQKLGWGPGSDWHSSVFSELSEKVFEECQVMLSATTLKRFWGVVNHESVPSISTLDTLSQFCGFQNWRDFKQQPFRKPRKQSYFPRKSLYVTAGFLLALLTVVLIGNKRPNAEELPEGIAFSSRALSRAYPNSVVFDLDLQGVQSDNVLIQQYWDPTKTISISDDQQQATGIYYFPGYFRAKLLIDDEVVASHDLFLKSNGWIGTVEYTPVPKYFRPGMSDEKELFYPEEIGAEVKASKDPLMTVYHYVDDLGEVSGDDFTLRANIRNTYDDQWAVCQSVGVYVLGTKGAMIIPFSRVGCSSDNNLMLNDVYLSGKANDLSAFGVDLSDFTEVSIAVKTKSVQVSVRGEVVYQSAYQKTMGRLVGLRFKFLGLGEVANYSLTSGGRNVTLVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV12</accession>
    <name>A0A654DV12_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="6">
        <location>
            <begin position="16"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="839"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="879" mass="99258" checksum="E1D6F1E45F2B590E" modified="2020-04-22" version="1">MSEENGREEEELHEVIPVSGMYENWFLDYASYVIMERAVPAIEDGLKPVQRRILHALKEMDDGRFNKVANVIGSTMQYHPHGDASIGDAIVNIGQKNLLIDTQGNWGDVRTGDSAAAARYIEARLSKFALDVIYNAQTTTWQLSYDGRKKEPVTFPVKFPLLLAQGVEGIAVGLSTKVLPHNFCEILEGAINILKGKKVVLYPDFLTGGKIDVSDYNDGKRGGKVRVRAVIEEMDSKTLIIKDIPFGTTTTSLIESIIKANDKGKIKIKKVIDNTAKDIEIQIQLAPNTSPDITIDALYAFTDCEVSISPNACVIYDDKPQFLDVTEILKHSVDQTVGLLRQELEIRRGELMEKILFSSLEKIFIENRIYRDIEECETWEAVLQTIDKGLDPFKPQFYRDITQDDIIRLTEIKIKRISKFDAFKADELMRKLTEELEETEHHLAHITEFAIAYYKNLLDKYGKGRERKTEIANFDTISAAVVAANNAKLYVNREDGFIGYGLKKDEFVCECSDIDDIIIFRKDGVCQVTRIQEKVFVGKNIIYAGVFNKADERMVYNLAYVDGKSGRSMVKRFQVLSVTRDREYDLTKGGKGSRVHYFSANPNGEAEVVTVYLTPASKARKKVFDFDFAEIEIKGRGAGGNILTKQPVRKVQFKSAGVSTLGGLDVWYDEVIGRLNTDKRGNHLGNFKAEDHIIVFYKDGSYELTSFELTNRYEPNQVLGLFKHEKDLPINAVHYDAGNKVYYVKRFLIETTTLDKRFSFVSEAKGSKLIFANNSDNTLISVTYKDGRKNETAQLDLAEVIDVKGWKALGNKCPYQNILSAAEVTPQKEEEEVDDEKEQEETGKTAVDLEALKSNIKHEVEEEDNQLGLFGGKSKDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV16</accession>
    <name>A0A654DV16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="59" mass="6711" checksum="D11795C0302EDA3F" modified="2020-04-22" version="1">MQFFAVWTGLEPATSCVTGRHSNQLNYHTVCSIALQNYTLTSSNATLHFKYFKCVFQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV62</accession>
    <name>A0A654DV62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11466" checksum="BD7F4AF5B7851BC1" modified="2020-04-22" version="1">MNDITPEELKSRLEKGETLPLFDVREDWEYDESNIGAELLPLASIPLRLKELEPLKTKEVIVHCKSGSRSHQAKKYLSKQGFRQVRSLIGGIEAYLNNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV87</accession>
    <name>A0A654DV87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="16156" checksum="C94E0E29E16BE355" modified="2020-04-22" version="1">MLEIKILGPSDTVGLIEIEQVRDFLFNHLDQYGDKKEDIMKAINYALSTGITPGGFVLVGKDQGEIVGAVVVNKTGMDGYIPENILVYIATHRERRGKGYGKALMQKAINTAEGDIALHVEPDNPAKGLYEKLGFTNKYLEMRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ8</accession>
    <name>A0A654DVJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative EF-hand domain pair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="23332" checksum="991A1B8BF5900DF0" modified="2020-04-22" version="1">MPVNNAMLQELQIRKLEHLFRIIDFDHNGLLQKSDFQSIADNVAIFTGIIEDDDHDNLLREEGNMIWGFIQAYFQQPNLQNIDSKQWIEFMENFFFGADDEVLDQNITLIVNRLQSVFDKNKDQLISRLEFMSIFVSFRVEVRFANQCFKAMDLNGDGFISTDELVHAAMDFFKSNDPDALGNKLFGELGSSHFQSVKVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU8</accession>
    <name>A0A654DVU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="30709" checksum="C4908428A5AA8555" modified="2020-04-22" version="1">MKTTKSNLFYRKSGKGPHPLILLHGFGQEHSAFDTWLKALENNHTVYAFDHYYHGQSTREDSPLTIAQWKQQFEDFLLREDITKFSIVGFSLGGRFALVTTNLFPERIRHLILIAPDGIFRSIWFRLATSSLGNPLFKYLMLHPDHFNTLLDTFKTLRITSSSMVRFAQKELQGKDNRKRVYRTWTYFKPIQVPISMVARVINQHGIQTHLILGTLDSIIPLGKILSKTTKIRTLETHKLPYKHHHMIEASKTLVPSLLSGEFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW40</accession>
    <name>A0A654DW40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022551">
        <property type="entry name" value="BrxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11009">
        <property type="entry name" value="DUF2847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11576" checksum="C878A0D3698CEB57" modified="2020-04-22" version="1">MVFKHRASSPESIEKKIELENGWNISSDMIDVYLVDDMKSKDVSREISEIAGINHEFPQIVLFADGVTMYDESHDMISVKKIKLALKIVNRTFKWMETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW50</accession>
    <name>A0A654DW50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoquinoline 1-oxidoreductase subunit alpha</fullName>
            <ecNumber evidence="3">1.3.99.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iorA</name>
        <name evidence="3" type="ORF">MARINOS108_10587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047121">
        <property type="term" value="F:isoquinoline 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="152" mass="16095" checksum="466F87270D1D145F" modified="2020-04-22" version="1">MASFTLKINGSSQSVEVDPDTPVLWVLRDHLRLVGTKYGCGMAQCGACTVLMDGYAVRSCSLPVSAVGDKAVTTIEGLSEKGDHPLQLAWEEKDVPQCGYCQAGQIMNAAALLSQNPNPTDEEIGAAMNGNICRCGTYTRIKAAIKTAAQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW83</accession>
    <name>A0A654DW83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid/polyamine/organocation transporter, APC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="438" mass="47784" checksum="57403495CFE9ADF4" modified="2020-04-22" version="1">MCESSYRPYQMLKREIRRWDLVLLLINSIIGAGIFGLPSKIYALSGIYSIAALLVCAVIVLIIVFNFAEVASRFDKTGGPYLYTLAAFGKIPAFVIGWILLITRISTYAALINLLATYLVYCYPPFQGQIWRAAIISGVTLLLTLINFIGVKSSTRVSNGLAIAKVLPLFIFVIVGFFFIDTSLIQTSQSYPSSGEFATSVLVLIFAFTGFESVLVNTGEIQNPAKNIPFALILSILCVAVFYDLIQVVSMGTLPGLATSNTPIADAAQLFMGSGGGWLITVGAVISISGTLNSVMLVGSRVPYALSEENQFPGIFGRLHRKYQTPTLSLLWFSGVALLGSLSGSFLYALSISVISKILIFLTVCGALIKLRRNKRQPTSYFKLPWGHLFAVGGIFASLWLLFSSKTAELVDVLITTAVGLMLFALYKLFIRRSEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWF7</accession>
    <name>A0A654DWF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5683" checksum="74327DCF3F547CA2" modified="2020-04-22" version="1">MDSFFDVITMLLTSYHSVLSFLGFLSGLIVNKFPLVEYICLFEVYPTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX0</accession>
    <name>A0A654DWX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmH family RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="27400" checksum="16A3E1EEAF76A483" modified="2020-04-22" version="1">MVSIKQSKFIKSLKIKKYRTKEKCFIIEGRKNVLEAIESNYTVRYLLATNDFLHNNTLPSTIVKDVIIKVDSNTLTELGTFQTNNDCLAVVEMPEQELAEVPFNDHLVVLDGVSDPGNMGTIIRTMDWFGLKYLICSQDSADVYNPKVVNATMGSFARVRVIYTDISRFISDAPVPSFGADLEGIAPSRWSTQEPVMLVMGSESHGLSPEVKAVISGKVSIPKVGMAESLNVAIATGILCHHLRFNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX76</accession>
    <name>A0A654DX76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="174" mass="19509" checksum="D3766021F77FE9CF" modified="2020-04-22" version="1">MRYTLLLLSMLVLACGPDDFHPDFNQESTMGFRPIYADSSELNIGLESARNIVSAGKIYSYGNLLLVNEVGKGLHVYDNTDPRKPVNKFFVTIPGNHDMAMKDGVLYADNYDDLLALQVSSDTVIVLKRLEDVIGFTAEFPSQNNVYFECVEEGKGIVVGWEQTMIEKPKCYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX77</accession>
    <name>A0A654DX77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M50-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="44935" checksum="6F4649A95C104C69" modified="2020-04-22" version="1">MIKKHKQLLIHIGLFLLTIITTTLAGAEWMYSKYVLWVDEDLLMTWDEFMGGFQFSIPFLLILTFHEFGHYFTARHHNIRVTLPYYIPMWLGFILSPSFGTMGAFIRIKDHIYSLKHYFDVGISGPLAGFVIAIGVIWYGFANLPEPEYIYQVHPEYEQYGLDYADHVYDNDSTASFRFGSNAIFWLFEEYVADPARMPHDNEIIHYPLLLAGYLALFFTALNLLPIGQLDGGHILFGLIGARRHEKVSKVLFSIFLFYAGLGLISIQDMADVGLESSLHFLILIGAYLYFLFICSASMFKSRQDRWMFAAIMFSAQFIVHYLFQWEGYSGWLLFGLLLGRFMGVVHPPVLDNTPLSTERKLLGWVALIIFILCFSPQPFILDIPELITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF4</accession>
    <name>A0A654DXF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22689" checksum="08F29EE7ABE0F7CF" modified="2020-04-22" version="1">MSISFWIELGLGILNSLNNIPTRMNRRNTLKALAAASVGTVALGYWAKDLTFIKDLMSNSFFKPSEQDLITSIADTIIPRGAYYGAVDLGVPVYLLGFFEKCQEKEEQDKLKLQLAALNMAANEKFNNDFVDCTTEQREQLLTEWSESKVEAEQDFFNLMKAETITGFRTTEEVMTNHYHYRVVPGHFLGCVDIHQPFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH4</accession>
    <name>A0A654DXH4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Suppressor of fused protein (SUFU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="1">
        <location>
            <begin position="42"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21283" checksum="089B5467C79E2F96" modified="2020-04-22" version="1">MNKPKTPIENYLSHLDSIFQTEPEFFGGEKRDGLAGVTSIVYSELPESGMVTGITYGLSLVEHPDWKLGRPELLISVESTDKSWAQAAGFIAEQLRGNCPFSYSNTINFGEPVSDESEMDAFLIFAPSILDKKFYLNIDIGLDYKINIAGLYPIYSSEMKLVNEWGLDKFWHHPDFNNYNVNRKRITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK0</accession>
    <name>A0A654DXK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Starch-binding associating with outer membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025069168" evidence="5">
        <location>
            <begin position="21"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="93"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="358"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="520" mass="57414" checksum="5E2E61E7313A4113" modified="2020-04-22" version="1">MKRSYILSAFFALGMLFAFSCDDLEEEPVGLLSPEGFFKTPADVQIGLNGGYSAIEHEAFWGRKLFLTLILRGDMVSIGDQTTAARRIEVDKMNMSSNNGMVSEFWPKGYEALAAINYALEGAKSVDAPEEELNAVVAEGRFLRAFIHYHFVRLFGEIPYIDVAFSDPALAYTLPQNPVADTYAGIIADLEFAKEWLPDAPALRSRPGKGTAAGLLASVHLTLENWNDAYDEAKWVIDNSGSFQYALEGEFADLFDPSIGAPSNELLFEIDFSGNDAAGAIGGSNPSTDYLASVTGPRKDERFGMGEGWSVAVPTLAVYDTWDSRDYRKAVSFDTLMTYLGEDTPYTEWGSIPLNVARPHIAKYYRSLGVSGAPSGLNGRDSEIDQPVMRYAEVLLIAAEALNEKNSGPNAEAEGYVNQVRSRARRELDGDPSNDRAFPANIASGMSQADFRTAVLEERRLELAFEGGRWYDIQRRKMAETAFGAGGLEQQAFNPARDYYLPKYQNDVDKNENLTQNLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN2</accession>
    <name>A0A654DXN2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4145 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4145" evidence="1">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="28134" checksum="4F7DB5FAED09CF47" modified="2020-04-22" version="1">MKKFDLNKSLDNNYSVLCQTCKVTTKHKVLTSVNEYGKEPMDDYGDFYQWNNDYEIIQCLGCETVSFRSDHANSEDYDPVDGDYYSNELLYPKRTKESLTAQSFFNVPPNLRRIYKETIESYNSDSLTLCGAGVRALVEGLCMENGITDGEVEQKQKDGTIKKVRKTNLQAKINGLHQKGKITEANADILHEHRFLGNTAVHELSTPNKDDLRLAIEIIENVFDNLYELPEKASQLRFQRLRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN9</accession>
    <name>A0A654DXN9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ORF">MARINOS108_10331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="439" mass="48206" checksum="D3C007F85B106745" modified="2020-04-22" version="1">MFDNLSVKLDRAFKTLKGQGNITEINVAATVKEIRRALIDADVNYKVAKEVTDSIKEKALGRDVLIAVSPGQLLTKIVAEELTILMGETNVPINLTGNPNIILISGLQGSGKTTFSGKLANQFKKQGRTVLLAACDVYRPAAIDQLKVLGEQIGVEVYTEPDEKNPLKIAKNAVKYAKEHGKKSLIIDTAGRLAVDEAMMDEIAGIKKEIQPSETLFVVDAMTGQDAVNTAAAFNQRLDFDGVVLTKLDGDTRGGAALSVRKEVSKPIKYISTGEKMDAIDLFHPDRMAKRILGMGDVLSLVEKAQQTFDEEEARRINKKIKKNQFGFDDFLSQMEQIKKMGNIKDLLGMVPGVGKAIKDIDIDDDSLKPIEAIIRSMTPLERENPNLINGSRRQRIANGSGTSVNQVNQLLKQFEQMRKMMKTMNKMGGAKALSNLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXU0</accession>
    <name>A0A654DXU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="193"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="30406" checksum="99C0E306867F0764" modified="2020-04-22" version="1">MFMKSSKSELINYWKQFSAENSKPVKEIDFNLVDRVARFFSPSIYYYYIFNFTTLRMEFVSDSYQSMTGLDRADFSLNRWLESIHPDEIDFVHQCEQVAGKFLFEFIPLDQIPRYKVSYTYKMRGPDDTYFQSLHQAIALSMTDNDTIGHVLGIETKIDQISKYPSKRISFLDLEGQENYLNIDVEHPTFDKINELPYGFTPQEMKIIELISLGHSSTEIAKMLFVSDHTIRTHRANILSKSPARNMTSLVADLFRQGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW7</accession>
    <name>A0A654DXW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_2" evidence="2">
        <location>
            <begin position="251"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="448" mass="49879" checksum="4BD05996A4E0466D" modified="2020-04-22" version="1">MIGQENSDSQFENEWKEVFGDASQTPPDAVWNEIDRKLAYAELSVYKTKATYYRWAVAAILLLAASLGTLQYWYFQQGTDYRLAINVDKPAPMEEVVSIRIPDSADERMTALAFGDQGRDKQVSRAAMFVASEQEQEEEVNDQSHSREIFEELTLTKLKPEVSIAANYTGRRLYLLPVYHFEQRRKAGVDNKYWAGLSLGSGGFDPNFQSTGGSLLASNLDMSSAGFSLSSEEAIDSQSPSVREGMLPGETVSLGVNFGLKLSSRWTLESGVQYARADATTQTNVVIQTSTFQEVIPATSQVRSVQQFEQAIDRQEVVEYDYRDVNLKNEFQFTSVPVKAGYLIVNSKFRMELNAGVITNFYMGNKLSGSDAEIAGLTIGPGSESPYREVSFSGLAGVEFGYQLLKNFDLVIEPNYRRSINSLTKENTSFTTNPSGFGLLTGVRYNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXZ6</accession>
    <name>A0A654DXZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025056284" evidence="1">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="17365" checksum="DF9E534374CBE157" modified="2020-04-22" version="1">MKNLKVALLVITIASLIVCTGCPEAGDDSSDFDVTGYWKTENSSVEPSADIAEKGDWTEFRLDLQSESDLLFAYSIENVPDGFNTVWPEGEGTYTYDATSKVIKFTASTGVEFEATVTDDNFPDDFTVQRKPSTNSSGRTSGLKDPWIFKMLDASDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY21</accession>
    <name>A0A654DY21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="31020" checksum="16B9BB425A69CE42" modified="2020-04-22" version="1">MKTLKNILVPTDFSERAGNALEQAIYLADRMGGRLLILHVYHRLIAEEDYEDHPDKLEKSIDRKFAKLLKEHPGLNRVPHEFRKERGLSLDNIVGTAQNEAIDLLVMATKGAKGFDEIWGTKTAKIIKRVDVPVFVIPDKTSLKRLKKVGLASDYSTSTVNREIQFLISLAKEMELTVDVITLNRDAKNMIRQELDNREVILKQLEEVKSDFHFTYHHSVEEGLVEYSLAHKVDLITILPKSYSFIERLFNESLTEKMTFHSPIPLLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE9</accession>
    <name>A0A654DYE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_12069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024796815" evidence="7">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="34634" checksum="4E3E8CCFB14B6884" modified="2020-04-22" version="1">MRLFIYLSLLFFALCLTTSAYAQDSLAVDTGDTSTLMIQVENAAARTNVRDEAPNLSEIFSMAKIFWALVFLLSGYIGIRVISKILEILAERSAQYRITLKGLIPVVRILGWILVLFIIVAGIFQPPATTILALSASVGVAVGFASQDILKNIFGGVMILFDRPFQVGDKIEVGSYYGEVTQIGLRSTRVVTPDDSLVSIPNSEIMNGSVSNSNAGEANCQVVAEIYLPITIDTVRVREIATQAAQVSKYVYLAKPIAVLFFNEVKDRKSFLKMRLKAYVMDIRSEFAFKSEMTEIVIKALIDEQLINDKDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP5</accession>
    <name>A0A654DYP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="PTHR40069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03833">
        <property type="entry name" value="TIGR03833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="66" mass="7355" checksum="D5FA725897A5C1B4" modified="2020-04-22" version="1">MSDGTIRSHVKVGQEVEIVQKHHQRTGELTAGEVKRILTNSPNHPHGIKVQLTTGEVGRVRHILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ7</accession>
    <name>A0A654DYQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion system protein Por</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025001880" evidence="1">
        <location>
            <begin position="21"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="623"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="867" mass="96233" checksum="3F4DF5A7955E908D" modified="2020-04-22" version="1">MRTFLIPTILFTALSLAAQGQIDHWESVILPGDTWSYQVPTSQPPVDWTQIGFNDAQWSQGASGIGYGDDDDQTIIDATLTVYMRLEFTIVSLAEVEQLLLDMDYDDGFVAYLNGTEIARSLVSGEPPAFDQPSDGLHEALLYTGADPERHEIDLSLLAEGTNVLAVEVHNESLTSSDLTGIPTLSVGVNATTSHYRSVPDWFDEPVEMEEVVLETSNLPIVIINTVGGQSIPNEPKIRASMTIIDNGPGEENAVTDSSNPASLDFDGHIEIEIRGSSSNCCSDKKQYALTTYDEVNEKDNVSLLGMPKENDWILNGFAFDPSLMRDYIAYQLSLKIGQYASRGRYCEVILNGDYVGVYVLQEKLKADDNRIDINKIEPEDNAGKALTGGYITKSDKTEGSDVAAWYMDNYSGWQTAFVHEHPKPTTVTSLQDNYIREIFFNLEAQALSNNDALNGGYPSIIDMPSFIDFMIMNELASNADAYQFSTYFHKDRNGKLRAGPVWDFNLTFGNDLFFWGYDRSHTNGWQFDDGDNVGAKFWTDLFLNPTFNCYLSKRWLELTAPGQPLHPDQINSFIDEVFANTEVAAERNHARWGIGEDRAEHVAIMKQWVIDRVSWITSQLGNGQTCVGESVPNLVITSINYHPMTADGKDEKDLEFIEITNTGSTTVDLTGVYFGGTGLVYQFPPNIALAAGHSVFLANEADAFREAYGFNPYDEFSRSLNNGGQTITLLNGYGMVIDEMTYSDEAPWPTEADGDGYFLSIIDPNADNNDPSNWKAENVISGTLLASQSPEPVISLFPNPTSGHLQIASARQLVTVQMYDVHGRLLQTIHPAEASVVMDISHLEKGIYLLQIQTNTQVYRRKVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ69</accession>
    <name>A0A654DZ69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029483">
        <property type="entry name" value="GH97_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019563">
        <property type="entry name" value="GH97_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029486">
        <property type="entry name" value="GH97_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14509">
        <property type="entry name" value="GH97_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14508">
        <property type="entry name" value="GH97_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10566">
        <property type="entry name" value="Glyco_hydro_97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH97_N" evidence="3">
        <location>
            <begin position="38"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_97" evidence="2">
        <location>
            <begin position="328"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="GH97_C" evidence="4">
        <location>
            <begin position="576"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="676" mass="76383" checksum="46DB1787876768D5" modified="2020-04-22" version="1">MKKPLFVYFNIMSKFTWVILIGLILTGCAEDAYGPIYVTSPDGKNTFELTLDENKTLLFAVLRNSEGVESTRVIQPSTIRLLSEDLDFTGAFEIVDVSTKTYQGEWKTRFGELSTIPDHYNETKVALESPGAKINLIIRAYNEGLAFAYEIPQQKGLKSISLDDELISYQFDKDYEVWSTPERRPGRLTAQGEYQKIPLSQLKPGAERPLLIEYRDDLKIALAEAKLVDYARLSYNADPNAQLAILSSLDGKLLRAKQDTITGALKSGRSQKDKVKKDLPFQSPWRVIMIGESYGDLLEKNYLIHNLNDPSAIADDSWIQPGKVLRETTLTTEGGLRAVDFVAAHHMQYVHFDAGWYGNEMDDSSDATTITLDPKRSKGPFDLEKITAYAREKGVKVMLYVNRRSLEKQLDELLPLFKEWGIAGIKYGFVRVGDHDATAWLHEAIKKAAAYGMVVDVHDEYRPTGFSRTYPNLLTQEGIAGDETSVTNEHTLITMFTRMLAGAADNTFCYYNKRVETMGSHASQLAKTVCLFSPLQFLYWYDRVPAAPEKLDGLWGDTKTIGNEPELEFFDNVPTTWDETKVLEAEIAQIGVMARRKGNDWFIGGVNGKSRRTVTINFDFLNDGEKYWAKLYTDDESIKTRTRVKIEELTLTSESNLEVELLPNNGFAMHLVPVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZH9</accession>
    <name>A0A654DZH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="26198" checksum="569FDD355648A19F" modified="2020-04-22" version="1">MLYFFQPKTSEGVFHLTDDEYQHCVKVLRKKAGDEIGIFDGKGMAYHAVITSITGKLCEFEITQKTQLEPRPFYNHIAIAPTKNTDRIEWFVEKACELGVDEISFVLTDNCERNKMRTERLEKKAVSALKQSKSGFLTRINPMVKLKDFLKADHNGLKFIAVVEPDLPYLSNELKSSQEVITLIGPEGDFSKVEVTEALSQGFRKVSLGKSTLRTETAGLMAAHMVNVVNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI1</accession>
    <name>A0A654DZI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="19540" checksum="38950323DB874E07" modified="2020-04-22" version="1">MKSWMIMLCFFITTCSFSQTSLEYTIDKGVVGELRIDDTVDNIYTIFDKEKEIKLVDRYIEASFSPAIEVSKNGESLFMVNLDCDKIYSFEIFSPKYETTRGITTASNFGQLKKAYKISSIENHEGALYAFVDSLDISFSLETMEVMKAGIDINEIKVGDIPDDIGIISIIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX6</accession>
    <name>A0A654DZX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="119" mass="13537" checksum="02015B2A4480AD08" modified="2020-04-22" version="1">MSIVSELEEVKSCSSHFVLAINDTLNVISGKWKLPIIGSLMYGKKRFKELERDIAKITPRMLSKELKELEVNGIVSRTVHPTTPVTVEYELTASGRSLKQVLEPMVEWGVQHRKRIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ1</accession>
    <name>A0A654DZZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DinB superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011466">
        <property type="entry name" value="DUF1572"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07609">
        <property type="entry name" value="DUF1572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="16925" checksum="15002DB9CE5150C4" modified="2020-04-22" version="1">MKEILITLFEKDLNILIREVDSYSEESDLWKTAPGITNSAGNLALHLVGNLQHFIGAVLGDTGYVRNREAEFSDRNVPKAKILQDIQETIAVVSATLTKLNDEQLNDIYPIEVFGKPMTTLHFLVHLEGHLNYHLGQVNYHRRLLASQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E086</accession>
    <name>A0A654E086_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="30695" checksum="5AB01FF81CA5AD66" modified="2020-04-22" version="1">MILIADAGGTKTDWRLLDDKQISQFTSRGFNLKTQEFDTYLRELPMELAGLKGISRIYFYTAGLVTEQDAQRINARLESFYPGAKSHAFSDTLGAARSLFAAQAGYVCLLGTGAGAALYDGQEIAERVPSLGYILGDEGSGADLGRSLLQTYLRQGLPADLQDTFKAQFSELNEAAVLEVVYKQPGANAFLAQFVPFIVEHQNHPFVYQLVSGGFHRYFQAFFPDKEKYQGAPFRFIGSVAHLLSNILRRVASGYGYRIDLIAQSPIAGLTLYHQEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F7</accession>
    <name>A0A654E0F7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025011582" evidence="3">
        <location>
            <begin position="25"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="431"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="650" mass="73173" checksum="95B25269F7146047" modified="2020-04-22" version="1">MKATYIIVLLCLFFSISCPIRVFAGATTDQPGTLITRADSCAKVPDFQCALELYELALTTGIDSSDSLTIRLALGDIRYQLGQFDLAFVQFDSALLMAEKMGLDYEKALALKGLAHILWRTGENVRATTLIIESIELSRKQQDTAAMITSSNILAGIYMSVGNLDDAGKLYQEALGMALGMQDSLNIAQAYEYLGVLEFFREDYYRAIDLYEQALQINLGMDRGLESGINYSNIAESLNKLGEYREALKYLKKGEKVMKRYDFLSGLIFVYYTMGDTYTQLKQYDLGIAFYQKSLELMELSGETREKQMVYGLMAENYAAQNKFEEAFIYHKRHAAAKDSLFNITKNNQLEEIRAKYDLEKKEQENFFLAKENEAKEEQLAIKQSTIRKQYIMGGLLVLLLLIAIYLSVKLYRNKLLLSRANKTKDKMFGFIAHDLISPMGIIKSLADLLSPDSGFDLTKQERDNMMRDMHNSASSVLILLKDVLLWSIAQQHGYDFKPKEVNLREVSQKNADLYHLHAKSKEIAIRNEVPEGIRAFADVKAVSTIIRNLISNAIKFTEKGGTITLSAALDDPSMVVLYVSDTGIGMTSSQLELILSRNELNTQKGTEDEHGSGLGLNLVKDFLKECKGRLNIKSEPNQGTTIEIYLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H7</accession>
    <name>A0A654E0H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="96" mass="10894" checksum="FE643F5F11F796E4" modified="2020-04-22" version="1">MANDTKGQVEKILAELGKKIDQLIVETKNASGDVREDVEKKIQELKKKKEKLEKDFESYKGKNEGKWQDAKSHLSSAIQELKKAIEAMFKDNSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I3</accession>
    <name>A0A654E0I3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="25782" checksum="18819D461F4413E1" modified="2020-04-22" version="1">MLFIRVLMCPRTTPTNTNMKPLNFLIVGGMALLLYACTGDTGTHTHGLGTHTHGSATETFSIEGLVDEIKTVPDSIIEYLHAQHHSHKVLERRTVPPGYATRELKNWKEYAARLDELPVINPGPGEYVHVMEGYKNGYQNLVIGITETFPGGAPPMHTHKGEESHVLLEGTILYALGDTLFTIEAPYIVNIPPMVPHAFKNIGEKTANLVVIFPTNVWEYDVLDYFPFEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J5</accession>
    <name>A0A654E0J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="309" mass="34413" checksum="B6CB0ED960E1B7C6" modified="2020-04-22" version="1">MRIAGVEIPVGKTKKIDVNIAKLPSGTLIDIPIIVYRAPKEGPTLMLLAGMHGDEINGVEIMRRIIREKLYKVDAGTVICIPIINIYGFINFSRDVPDGKDINRSFPGSKTGSLASQVAHFMMQEIIPHIDYGVDFHTGGARINNSPQVRVQTDDAQNLELAQAFGTRFILNSPYREKSLRKEAFKHGKRILVYEGGESLRLRKSAIDEGISGMQRVMKHLKMKDSAPKPERETILINKSTWVRAKSAGLHYSFVRNGSKIIPKEILGEVCDPYGTYQVKIKSPLEGYIIAVNNHPVINRGDALFHVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S1</accession>
    <name>A0A654E0S1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="10698" checksum="C50B3CCA23F4BF05" modified="2020-04-22" version="1">MDIIDVGLYASYILIVLCALAAIIIPLAQSLGDPQSLIKSGIGLGALIVVFLIGYIIAGSDTGSADITESTSKLVGGGIISMYIFFFIALAGIVYTEISKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U9</accession>
    <name>A0A654E0U9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="80"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="317"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="456"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="567" mass="63979" checksum="B324BFCC79661B05" modified="2020-04-22" version="1">MEKRWELRDIPNTDYLESLSKELNINKDLTALLLQRGITEFEQSKSFFRPSLSHLHDPFLMKDMDKAVNRLCEAIFSNTKILIYGDYDVDGTTSVSLMYGFLKSFSDHLEYYIPDRYTEGYGISTKGIEYAHDNGFQLIISLDCGIRAVDKAALANSYDIDLIICDHHIPGEQLPEAHAILDPKQPECPYPFKELSGCGVGFKLLQGFCMQNSIPLEQLYQHLDLVAVSIASDIVPIVGENRVLAFYGLKKLNHSPCPGLKALMEVSGLKNEIDISSIVFYLGPRINATGRLTHAHDSVRLLTAENDSETEAFASVLNAKNAQRKDFDKTITEEALSMVEEDESLKLAKSTVLFKNDWHKGVIGIVASRCIEKYYRPTIILTESKNKATGSARSIEGFDIHEAISSCSDLLEQFGGHTHAAGLTLPLENVAAFRQKFEKIVSETINLEILQPKLEIDLEVDLSFVNYKNYMIIKQMSPFGPQNLKPVFVTKNVKLKFPPKIIKDEHLKASFYQEGNHLAYEAIGFGLAEKSEDLLNHEVFQVVYQIEENTYRGNKSLQLNIKDIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W6</accession>
    <name>A0A654E0W6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">glsA</name>
        <name evidence="6" type="ORF">MARINOS108_11478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="33843" checksum="A47727392617D860" modified="2020-04-22" version="1">MTPDYDQIINEIYNELKDAPDEGTVADYIPDLAHIDRTKFGICLTTLDGKQNKVGDADEKFSLQSVTKVLSLSLVFSQLGNKVWDRVDVEPSGNGFNSIIQLEYENGFPRNPFINAGAIVIADMLVSLHKDPKAVFLNYIRGLCGNTDIQYNEKVALSEKSVGYGNYSLAYMIKSKGNLVNDVDEVLDFYFWQCSVEMTCAELAQTFLNFGETNVPFGHGNYMLTASQSRRMNALMLTCGFYDESGEFAFEVGLPGKSGVGGAIVALNPLRYCVSVWSPPLNVKGNSYKGMKALEMLTTKLGRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E119</accession>
    <name>A0A654E119_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="PTHR12390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="33"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="30085" checksum="8CA7CD15DCFF3E67" modified="2020-04-22" version="1">MSEELLVTDKERLNRVSSILVSQPEPTDQNSPYQKLAEKYDLKIDFRQFIEIDPVDAKEFRKQKVNILDHTAVIFTSRNAVDHFFRLAAENKVEIPTDMKYFCISEQTANYLQKYIVIRKRKIFTGERTAQDLLEVMKKHKKEKFIFPCSDIRKDDIPDFMEKNGYDFSEVIIYRTVASDLSDLSDIFYDIIAFFSPSGIKSLFDNFPNFKQNKTRIAAFGPTTAKAVRDAGLILDIQAPLPNAPSMTGALELYIKKANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A6</accession>
    <name>A0A654E1A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative fused malic enzyme oxidoreductase putative phosphotransacetylase</fullName>
            <ecNumber evidence="10">1.1.1.40</ecNumber>
            <ecNumber evidence="10">2.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">maeB</name>
        <name evidence="10" type="ORF">MARINOS108_20029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="10"/>
    <dbReference type="EC" id="2.3.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
        <property type="entry name" value="ME_PTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="malic" evidence="9">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="8">
        <location>
            <begin position="164"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="763" mass="83448" checksum="6A0874B3C2286F78" modified="2020-04-22" version="1">MCAKIRRQEALDFHESKPAGKIEVTPTKPLSSQHDLALAYSPGVAEPCLEIAANKEDVYRYTAKGNLVGVISNGTAVLGLGNIGPEASKPVMEGKGVLFKKFAGIDVFDIEIDETDPDKFIQIVKSLEPTFGGINLEDIKAPESFKIEKELREKMSIPVMHDDQHGTAIISSAALINALEVCGKKIEEVTIVVSGAGAAAIACTDLYTSLGARKENILMTDSKGVVKKSRGNLDESKARYATDREDVDTLEDALVGADVFLGLSIGNILKPATLKKMAKDPIVFALANPDPEIAYDLAMKTRKDILMATGRSDHPNQVNNVLGFPYIFRGALDVRATAINEEMKLAAVKAIANLAKQTVPEMVLKAYGQSNLKFGREYLIPKPLDPRLITTISPAVAKAAIGSGVARIEITDWEKYELELQERIGIDQRLISRIVTRARRNPKKVVFAEADDVNILKAAQMSMDEGVAIPILLGNEEKIISLIKENELEGLLDCKITDPYKEESRVNQYAEVFYKMRQRKGMTLKMAQKSMMRSRNHFGAMMVQLGEGDALISGLSNDYPKTILPALQIIGVEPGINRVAGMYIISNNKGNFFFADTTVNLNPTAEELVDIIGLTARVVKFFDTEPRIAMLSYSNFGSARGEVPEKAAKAVKLAKEKWPQLVIDGDIQANVALNKDLLRENYPFSELAKNPANTLIFPDLDSGNIAYKLLMELGGAEAIGPVLMGMNKSVHVLQVGSSVRDIFNMVAIAVVDAQLNEKREKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D9</accession>
    <name>A0A654E1D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gliding motility-associated protein GldM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019859">
        <property type="entry name" value="Motility-assoc_prot_GldM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022719">
        <property type="entry name" value="Motility-assoc_prot_GldM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022720">
        <property type="entry name" value="Motility-assoc_prot_GldM_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12080">
        <property type="entry name" value="GldM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12081">
        <property type="entry name" value="GldM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03517">
        <property type="entry name" value="GldM_gliding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="GldM_N" evidence="3">
        <location>
            <begin position="32"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GldM_C" evidence="2">
        <location>
            <begin position="352"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="549" mass="59889" checksum="248D6FBCA7B28796" modified="2020-04-22" version="1">MSGGKETPRQKLIGMMYLVLTALLALNVSITIIDKFVFLDDSLVKANRESEERNGQIVESIIKTVDDSGNREDDVKVAELAQEIRTETSKMLKELTELKIALVEESGGYEEGKSPEYPGDAKHLIGKTDYSTVGHYMMPLEDGGQGHGIELKERLNKFPEILKEKLSSIGASETDLAAYKKIAVDADEDPVYKEDPNQKGKAFADLAFSDSPTPAGIATISEFQSRILSYETRALDFLSDKVGAGDLKFDVIVPMVKPESRYVAAGTKYTAKMFIAASSSGVTPTMTYDGNEIEVDASGQGLVEFTANSSTFDAEGLAKKTYEAAITVTLPGGRDTTFTDVVEYFVVKPTIQIQSTSVNALYLRCGNNLDVQVPQLGVAYNPAFSATNAKTYQGSAKGQVTIVPTSTEQVVLKVSSNGNLIGSREFGVRRIPAPTITVYTDQGEVNMKTGISAKTPRLYIKAVPDESFQQFLPEDAKFRVAEAQITLVSGGIGRTTITVGETANLTAITSQARKGDQLSIEIRKVQRQNFRKEVEDFNNYNRFINISLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E4</accession>
    <name>A0A654E1E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="368" mass="41844" checksum="C9D5FF85A37BC76C" modified="2020-04-22" version="1">MRIFPLITLLLLFITACNPEQKVPTDWQLTGFIKMDANNPVLTPDTTTLFVDPIKGDTVKWEGKDVFNPASVVRNDTLFLLYRAEDFVGRYNGTSRIGLAYSLDGLHFIRYPQPVFFPQEDEAKIYEWEGGAEDPRIVEDENGRYIMTYTGYDGDLARLLLATSNDLINWTKYGSAFARQEDIDRWSKSGSIVSEMRDGRLIAKKINGQYWMYFGDTDLFLATSDDLIKWTPVKDADGEWIKVLSPREGKFDSDLVEPGPPAMLTKNGILLIYNSRNALDDRYDPTLAHGTYSAGQVLFDPEHPERILARAEDYFFTPDKDYEITGQVNNVCFLEGLSLYKGQWFVYYGTADSKIAVAVAPERDGLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L6</accession>
    <name>A0A654E1L6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ORF">MARINOS108_120495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="29808" checksum="9CA65ADBC2BC399A" modified="2020-04-22" version="1">MAVKKLRPVTPGQRFRVAPVFDKITKTTPEKSLLTSKGKKGGRNNQGRMTIRNVGGGHKQKLRTIDFKRDKEGIPATVKAIEYDPGRTARIALLFYADGEKRYIIAPANLEVGTEIISGPGVPPEVGNALPLSDIPLGTIVHNIELKPGKGGAITRSAGTYAQLVAREGKYATLKLPSGEMRMVLITCYATIGIVSNNDHMNVRLGKAGRNRWKGRRPRVRGVVMNPVDHPMGGGEGRSSGGHPRSRNGLYTKGKKTRKPNKYSDKLIITKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M4</accession>
    <name>A0A654E1M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron complex outermembrane receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024934240" evidence="6">
        <location>
            <begin position="22"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="116"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="359"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="885" mass="95796" checksum="3C199BBF8A2E0DDD" modified="2020-04-22" version="1">MKIMRKILLLTLAVISYTSWAQVNISGKVTDDSGQEVVGATVLEKGTSNGVITDYEGKFSLQVSSSNAVLTFSFVGFKSQEVAVAGQTNLSVTMREGLELGAVTVVGSRNENRTELSTPVPVDVIDLAEIPSRNGQIEINQILQYAAPSFNSSKQSGSDGADHIDPATLRGLGPDQTLVLINGKRRHQSSLINVFGTRGRGNTGTDLNAIPVASIKRIEILRDGASAQYGSDAIAGVINIVLKDNTGDISGNVTYGAYSTAAKGTFDPGTANADGKNRLYDDDRSFDGNTVRASLNYGLDIGDDGGFVNFTTEFVNKEKVLRPGASFRQGYGEAGIQGFNFMVNASVPVGDKTEFYAFGGRNFRNTDAYAFSRDAESGRNVSSIYPNGFTPRITSIISDASVSTGFKQILPNGWKMDVNNSFGKNDFHYYIKNTVNASLEEASPTDFDAGGHSLAMNVTSATLTKYYDGFLSGTNLAFGMEYRTETFGIFSGEEGSYATYDTLGLAITGPDQQAPEYNDEPRPGGSQGFPGYSPANEVLRSRSNLALYVDTEFNITEQFLLGAAVRYENYSDFGETFNYKLASRLELTDNLALRGSLSSGFRAPSLAQIYYNLRFTNFIGGEALEVLLAPNNSPVTRGFGIEQLKQETAKNASLGVTLGAGNFTATVDGYYITVKDRIVLTDYFDASSLNINVVDAQFFANGLDTKTTGVDMVLNYRAQLGANRLNVALTGNINDISIEKINNGNLDADVFFGPREQYFLKASAPPSKFGLNIGYFTDRFDVSLAFTRFSEITVLDWQIYEDDADYGGYQNKLNASKDVYEAGVVTDLSVSFQVTDGLTLSLGGNNIFNVYPSQQDDWTDSGGYWDSVQMGVGGAYFFGRIGFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P6</accession>
    <name>A0A654E1P6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_20095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="37971" checksum="97EA8000E0428457" modified="2020-04-22" version="1">MSRKLVFRVILAVVVVVAIYRVFMGQPGFQLTHITGQTMGTIIYNVKYLGDDVPGYKTEIDSILQAFNQSLSTYIPDSEISLLNRTDSILYPTKMFTEVLESSRLVFERTNGAFDPTVGPLVNAWGFGPDKSVTVPDSSVIDSLRSMVGFERIITQGSQVRMDPGMYLDFSAIAKGYAVDLVAEFLEGRGLEHYMVEIGGEVRARGQNLDNETWKIGIEDPMVARDQQRLLAIVQLDDLSMATSGNYRNYYQVGDRIIAHTIDPRTGYNTSHNLLSASVFAEDCMTADAYATAFMVLGVEGAKEILSTTELEAFLIYQDDEGKLKSFVSSGLQSLIERNNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T1</accession>
    <name>A0A654E1T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021458">
        <property type="entry name" value="DUF3109"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11307">
        <property type="entry name" value="DUF3109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21560" checksum="C1AF4C77BD952F64" modified="2020-04-22" version="1">MIQIDQTLISDDIKEQFFVCDLDKCKGACCVEGDLGAPLDKDELADMEEVMEVVKPYLSAQAIAALEANGAYLLDEEGDFSTTTIDNKECAFAFYDEKKILKCSIEQAWRDGKTSIRKPISCHLYPIRVAKLHDFLALNYDRWHICSPACELGEKLSVPVYKFLKDPLIRRFGQDWYQRLCEEIESSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V8</accession>
    <name>A0A654E1V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="142"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="36748" checksum="2AB36DCD8650E77B" modified="2020-04-22" version="1">MNKKIKENQVNWGIVGVGDVCEVKSAPAMNLVANSRIEAVMRRNADKAQDYAKRHQIEKWYSDADALINDPKVNAIYIATPPDAHLEYTIKAANAGKPVYVEKPMARTHAECQEMISVCEKAGVPLYVAYYRRALPHFLKIKELIESGAIGDVRFVEVRMCKPLVPDIITHQTNHWRVNPEVSGGGYFYDLASHQLDFLDFLFGPIRKASGYSANQGGQYKAEDIVTASFEFTKGVLGTGSWCFASGEVSDKDITTIVGSKGEISYVSFGKAEVTLRRDASEDKVFSFDLPKHIQQPLIQQVVDDLLGNGMCVSTGVSGARTNQVMEWMANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W5</accession>
    <name>A0A654E1W5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025033654" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="115"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="776" mass="86752" checksum="C7CE7B8B4096ACE5" modified="2020-04-22" version="1">MKKLLLYIAQVLITFTVLAQSYQVQGIVTDEAGEGIPGITVTIKGTGSGVSTDLSGSFSLPLMGQSILVFSGIGFESTEQQVDRSTTTLKIKLRSSTTELSAVQVIGKSEHTETREQPFAVSVVDVKPLKVQNLDVNQILGTVSGVRIREQGGMGSGFDFSLNGFTGKQVKFFLDGIPMDNFGSSLSLNNIPVNMITGIEVYKGVVPVHLGSDALGGAVNVTTDQNVRNYLNASYAIGSFNTHRASVLARYTEPRTGLSFNANLFLNYSDNNYMMRDVEVPRSDGSGKLDTVDVRRFHDAYQSQTAQLELGVVNKPFADRLFVGLIASGNEKEVQTGLNMQDVFGEVMTTDQVLIPTFKYRKSNLFVTGLDLRAYAMYNRRKAVRADTSSRTYNWYGDYSTRINNAGEFSYNKSLFSYDDESYLATANLSYQLGKNHSVSVNHTFSQFSRVGKDPMRDLSEVPFTTPNTITKNISALSYSLSLMDDQWKTSVFTKAFMMHSSTQVESEDTDEFEEYNIQFLLNGYGVASTYFVTPWAQVKLSYENTYRLPEGEEMFGNGLTVLANTTLEPEQSNNYNAGILVSKVFKDHTIRFEGNYLYRKASNFIRLDASQPRNSNYVNQAKVNLASIEGGVQYTYMRLLNLGINVTKQKNINADESDRLFKDDLPNQPFLFGNLTAGVQFHHVGLEDSRLSINWLSLFVDQFYWKWPSQGTKKYKYDIPRQLSHNLALSYAFDEGKYSASLACNNITNTIVYDNFAMQKPGRSFSLKLSYFLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1X1</accession>
    <name>A0A654E1X1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4301 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025393">
        <property type="entry name" value="DUF4301"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14134">
        <property type="entry name" value="DUF4301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4301" evidence="1">
        <location>
            <begin position="4"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="514" mass="57298" checksum="C40F6719BC9F0E4F" modified="2020-04-22" version="1">MFSASDLKQISDHQLTQEGINAQIEKFKSGFPPSDLSENIQKGNGLKQLTAEEAESMITFYENNLEGLEIVKFVPASGAASRMFKSLFAFLTDYKGTDAEYEKMVADQGSGSVFTFFKKLDQFAFYEDLRAAYKKATGTSLEEAQLKREYTQILDVLLNEPGMNYGGLPKGLLKFHQYPEGPRTPVEEHMVEGAQYAQDKNGNVKIHFTVSPDHMEKFTAHVSEIQTRYESLFGVKIEVSYSIQKPSTDTIAVDMANEPFRESDGSLLFRPAGHGALLENLNDIDADVIFLKNIDNVVPDKIKTETIRYKKVIAGILLDYQQRIKLALETLDKGEGIEEALSLLQNHLGYRPGQSFGNLTDAQKCDFLAQKLDRPLRICGMVKSEGDTGGGPFWVSGEDGSVSLQVVETAQIDLTNEKQKEIFNQSTHFNPVDVVCGVKDKTGRKYNLLDHRDMNTGFITEKSKDGKDLKAQELPGLWNGSMADWNTVFVEVPAITFNPVKSVNDLLKPEHQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z3</accession>
    <name>A0A654E1Z3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="31029" checksum="41A6E90821FB9DC5" modified="2020-04-22" version="1">MKKILVPTDFSDCAQNATEVAKEIARRYHAELHFYHFVSVPVDWVHLDFAQHTIYPDVTEEVKRVQNQLDAAVKNAEADGLQSVAYMDFDNSTDAVTRYARSNNISMIVMGSHGARGVKEFFIGSNAQTVVRHAEVPVLIVKQKLKSVAFPNILFVSDFEDEMIRPFEDVVDFAELLGAKINLLYVNTPSEFQRSWIIKERMEGFIALASGNLGNVEIIDSHSFGEGLEKYCEMNQTGLLAIATHHRKGLSRAFLGSLTETVVNHVKVPVVSFPILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z5</accession>
    <name>A0A654E1Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase regulatory-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="602" mass="65468" checksum="492687986E05B2CC" modified="2020-04-22" version="1">MRNEILRFATCMLIGLVFLSLSSCDKDETPQAAELGSITGVVVDEGGQAVADVNVTVASLNEEDISLTTGADGAFLAENLPLKTHTITFSKTGWLTVSITVGVDKFDDSNVATADVTMVNASAKISGTVTDSKNNDAPIAGVSVSTGSETVTTGEDGTYAIENLVEDDYTITFSKDTYVTVVKEITSSDFVDGVATVDAKLGADELLRGFTSEDLLNADKWYYNEYRGGRNADAYPHWDWACDYMSTLDFQGAWQEQNEGTTLQIRNGEEDQDNPADLDVFDSFVYGSKLMTEDNKILSIRLRTHDADETAPAHYGVQVVDLSAAQPAAVKVGGNKTYGSGDYADIDFDLSDYVGKEVIIAIGIYREATGDYWKQLVLRAIRFSNQKVEGTNWLPGTEVIEGWKLTQETVRSTMPHTKSSFTGISPVSGNRDNYVDAYRAWRDVDHIGAEWSFVPLKKDPEVFASEGYIIKTRNTAEVSTTVPEAYMYAKFSIASGSNQMTLNTRNFGDNPTYFKLTAIQDNGTVTHIAPTSNTAQEASAAADGCWTFKHGDGGADNPEGYASFVYDLSQFDGEDVTLAFGVYNGVADSGENKLVFYSIELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z9</accession>
    <name>A0A654E1Z9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024909665" description="FGE-sulfatase domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="344" mass="38968" checksum="28E2FFBB7D6CA1AA" modified="2020-04-22" version="1">MNNMRVIKFSTLAVLALGVLLQSCGLFGGGSTDRGELVGVLDRQGWEMTRPFGMVAVPSGTFHMGQADEDVAATQINFNKQVTIGAFFMDDTEITNNEYRQFTQAITEGSEVDLPAGYSIADLMPDTTVWTSDFTHHMGDPLVVYYWSHPAFDDYPVVGVDWNAAQYFCVWRTQHLNEYRQSLGMPVMPAFRLPSEAEWEYAARGGRDMAKYPWGNPYVRNQKGCLLANFKPGRGNYFDDGFAYTSPINTYFSNDYGLYDMSGNVAEWCEDAYNPSAMPLVWDLNPTYYDERIDFKIVRGGSWKDIAYYLETGTRSFEHRDTARSSIGFRCAMTYLGRSSGYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E264</accession>
    <name>A0A654E264_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="504" mass="55918" checksum="CA834D6ABB0618E0" modified="2020-04-22" version="1">MKVEILDTTLRDGEQTSGVSFTDSEKLTIAQLLLEELRVDRLEVASARVSEGEFKGAKKILDWAAQNGYLDRIEILGFVDHTISVDWIKESGGRVINLLCKGSRKHCESQLRKTVEEHLADIAQTIGYAHEQGLTVNVYLEDWSNGMRTSPDYVDQMVEGLLKLPVSHIMLPDTLGILNHKESATFCGQMTAKFPQARFDFHAHNDYDLSTANVYSALEAGITGIHTTLNGLGERAGNVPLSSVIGIVKDHLHGEMNIDETKLYKVSKIVESFSGIRIPANKPLVGEFVFTQTSGIHADGDSKDNLYHNSLNPERFGRHYSYALGKMSGKANIKKNLEELGIELSKEETKKITEKIIELGDKKEAITKEDLPFIINDVLRSEKIEQHVQIKNYSLSVAQGLRSVATLCIEIGGKTFEKTASGDGQYDAFMNSLKRIYKDLGESLPRLVDYEVQIPPGGETDALVITTITWANGKTFKTRGLDPDQTVAAIKATVKMLNIIKNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E296</accession>
    <name>A0A654E296_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="29084" checksum="A206A9D559515AAF" modified="2020-04-22" version="1">MMNQEHFTVADLSIDQVVAKLEEFGLVVIPNYLGADDVEKLFKEFYEFTETEDTPYKKNTPYSEGVATRVKRLEMDTERFKKTEEVFGSQFMREITDKYWSKEAGLNEEIFVVKDVLGSKHVASDLHFDVKPTLKYFIYLNDTTAENGAFSCVPGSHKVTHKLRQKHQGKLSYKNRELTRELPVSEEDVIPIEGRAGTLIIFSTEVFHKAGNITKGERYVMRGHSRTAEQDRMGDTTGPFEHLKRKLKSFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A0</accession>
    <name>A0A654E2A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024871094" description="DUF547 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="27190" checksum="78F6CEF14A59705C" modified="2020-04-22" version="1">MRYFLILTICMSFFEASAQTFFDRADAFFSQYVDEGNVNYALIRKEPRTLNALVKEIAELDLSNKRVTADYLKSFYINAYNILVIKQVVDRYPIAGPLKVEGFFNGIKHTVMGQEMTLDELEKGTLYKQFPDPRLHFVLVCAAKGCPPLASYSYKPAGLDRQLTTRTREVLNLDWFIRVNNGKVQVSQIFEWYKGDFEKDGESVKTFINQYRKPAIEENMKLGSYEYDWALNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D4</accession>
    <name>A0A654E2D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="5">Glu-ADT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">gatA</name>
        <name evidence="7" type="ORF">MARINOS108_20026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="51876" checksum="36E4C35946BC5736" modified="2020-04-22" version="1">MRAQSSFSEIRQQLDAGKISCGQIVDHYLKNIREKNGKLNALLSVYDQEAKEQAHLIDQKIKSGSAGKLAGLVVTIKDVLCYKDHPLQCGSKILDGFQSQFTATAVQRLLDADAIIIGRNNCDEFAMGSSNENSAFSPVVNADGHNRVPGGSSGGSAVAVQADMCAVSLGTDTGGSVRQPASFCGIVGLKPTYSRISRHGLAAYASTFDCIGIFSNNVKDSALVLEVISGEDEYDSTVSQKEVPAYSEHLEAGKRYKIGYLKETMDNEALNSEVKAAFAQQIDELRAQGHQVEEISFPLMEYTLPTYYILTTAEASSNLSRYDGVRYGHRTTEAGNLEEMYKKSRSEGFGEEVIKRILLGTAVLSASYHDAYYIKAQKARRMIQNELNELLERFDFIIMPTAPTTAFELGSKTENSMEMYLADLFTVQASVAGVPAISIPMGRDRQGMSIGLQILSKAFEEQKLLAFSNYLLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K3</accession>
    <name>A0A654E2K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="46"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="325" mass="35695" checksum="14FA4DA172EB628D" modified="2020-04-22" version="1">MEYRMFGESGCSVSCMGLGLAALGRPGYINLGHREDLGSEYDPSKMEAQTHAMLSLARAQGINYFDAAQSYGKAETFLSTWLMAHPREEVVVGSKWGYYYTADWSVQADKHEVKEHTLERLNLQWPESEQRLGTALKIYQIHSATLESGVLENRAVLQRLEEIREMGYVIGLSLSGVQQSVVLEKALAVQVGGKPLFGSVQATYNCLEQSAGEALQKAFDRGLGVIVKEGLANGRLTSRSTGAYLKTLTDMAQSYQVTEDAIALAYVLSKPFVSVVLSGAAVPAHLISNVKGSEIKLSQQDIRVLDGLKVKPEHYWAERASLAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N5</accession>
    <name>A0A654E2N5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oxaloacetate decarboxylase beta chain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">oadB</name>
        <name evidence="9" type="ORF">MARINOS108_20509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="42361" checksum="CE76D93064A042EA" modified="2020-04-22" version="1">MELLEKLYQMTAIQNMVDEPQILLMIFIALFLLYLGIKKQYEPLLLVPIAFGMLIANFPGGQMGVEKIDENLTLYQIARDHGIMNFVYYSLIKTGFLPPIIFLGVGALTDFGPMLRNLRLAFFGAAAQIGIFTVLISAVAFGFTLKEAAALGIIGGADGPTAIYTTIKLAPHLLGPIAIAAYSYMALVPVIIPLVVRLTTNKKELLINMKQQDKLYPSRRPIKDLQTLKILFPIGVGTIVALLVPSSVPLIGLLMFGNLVKEIGVSTGRLHKAASDTILNAATIFLGLAVGATMTAKAFLNMETIMIIVGGFIAFAISIAGGIYAVKVYNLFAKKKINPLIGATGLSAVPMASRVANEIALKHDPNNHLLQYAMASNISGVIGSAVAAGVLISFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Q5</accession>
    <name>A0A654E2Q5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="446" mass="50997" checksum="9F5DFB4B55CDDF47" modified="2020-04-22" version="1">MIFVFLILVAIRVTWIIAGLPLSLPELKWLLVGERLSDGFTMYKDLYDHTGPLAAFIYKWLDFVFGRSRWVHLVVSTFLVTVQAGIFNRILLKNKAYDENGYVPAFLYIVLMSSVMDFFALSPQLMAITFILLSLNHIFRRIDNVVTDELFLLSGIYLGVATCFYLPAAVFFVIFLLSFILFSSAVPRRLLLLVYGAGVVFVVIWAYFFWFGAGRDFLDDFFVEGVSKARIFYVSFMELLGIGGFLLGVTLLSLTVLFSLRVTNYQQKMQQVMVSFMLAAFLVVLFSRDLMSADLIFFVPTTTFFLVHYFLGLRRKVWKVLMPYLMVIGLLVYPNVWLRNNPPSGLLVKPSEVKVPGNRLMGLGLDVADYQEYVLAGPFLDAEVSRKKMEDLHYYDEASGLFETLEQSAPDAIIDQWGDMAQIFERFPVFSAHYQETSPGVYLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E358</accession>
    <name>A0A654E358_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">nth</name>
        <name evidence="12" type="ORF">MARINOS108_20286</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="24824" checksum="7B423ED3C5486484" modified="2020-04-22" version="1">MTKKERFEAFVSYFKEAFPEPQTELNYNSPFELVVAVVLSAQCTDVRINKVTPALFKAFPTPEHMAAGTFDEIFELIRSVSYPNNKSKHLMGLSKMIMEDFGGEVPHRHEDLQKLPGVGRKTANVVVSVLYNQPAMAVDTHVFRVSKRLGLVTQTAKTPLEVEKQLVRHIPNEYVHKAHHWLILHGRYVCLARKPKCEECKITHFCKYWEKKSNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E381</accession>
    <name>A0A654E381_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="32995" checksum="5AAC08787327021A" modified="2020-04-22" version="1">MLRLVFTAAFGLLFSFCYGQLKKFYTLKETSGYSTIDFTLEATAGNCFIKSSDSEGPLSIYGNPDLDKINPSFRSKIVDDVCKVHLDLQEFRSSSLSDGILLAMIRDKSEQNNYWKIIFDREKKYRLNLSYGFGNADVDLSGTSVQNFKVRSGSADILVDYSDGEPNKIEMDTFWVKADMGSIVARHLELARAKYVMANIGFGRALLDFSDASDTRCTVDASVGAGNLDVFLPGRDVPMIIYMKDSPLCGMRLAEGFEEVERNVFVNMNYRADAKNLLTFKVDVALGNVAFHYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A0</accession>
    <name>A0A654E3A0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="407"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="632" mass="71864" checksum="53D59A2B97EC120C" modified="2020-04-22" version="1">MILLLFSILLSPLHINRSVADSLAVIEDQSIESRILELNRQIEEHSDTLALARYTFLLGKEYAKMDFTDKALEELNQSFRYYRAAGDSAGMADVLRQISFTYSLVQEYDKALDFILRASGYATDLKQVREINHRIGYVYFNLKQLDSAEKYLNMAVGQYAQTGEVGASSLINLAGINISRARYREALAGLLQVEREGLQSLTPSSQYFVFNFISALYLKLGNEVMGRLYRSKRDSLTVDLAHLEKTLDFYETNIIADTLIGDYTAAVQKQGKYVEQLKSYYKNNLTTQLANYQKLFELQEKEMAIDLLEKENQVYELRQYESRSYIIFLILGVTILLLVVVITYRSLSNRNKLNQELQVLNAQISSQHDDLQRKNDLLKKIISDLKGTQYQLIQSEKMASIGSFASGVAHELNNPMNILSGGLQVIEKNLAEVMNAHSENQEELLEDINIMLRESNFSISKINRIIQALIIATYTEHKPKVLDFTEIVDNVLIAFSRMSHPEVRFSTKVDSVSLECFPNRIHHALKAVLENAFFFAKESSSDEKCVWVVACQKGESLEVRIENNGPAIPEDHLIRIFDPFYTTKDDGVSPGLGLYFAFSAVKEHEGRIEAKNEGDRVVFTMTLPVRMSVAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A3</accession>
    <name>A0A654E3A3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ORF">MARINOS108_20391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="131"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="44194" checksum="6F32DB68B8D08D4D" modified="2020-04-22" version="1">MYDPVSSFTEFKAKSSHLCGMKRDITDLRIGVLGGGQLGRMMLQSATDFNLEIHMIDPDPSAPCAKIAHSFVQGDLQDYDAVMAFGKQMDLITIEIEAVNTDALKALQAQGKKVFPQPEIIELIQDKRKQKTFYKANRIPTADFILTENKAEVAQHRDFLPAVNKLGKGGYDGRGVQVLRSEKDLDKAFEAPSLLEKLIDFKKELSVIVARSASGEVKCFPLVELVFHPQANLVEFLFAPAEVSAAIEAEAQQLAEDVITKLDMVGLLAVEMFLTQDDQLLVNEIAPRTHNSGHHTIEANITSQFEQHLRAILDLPLGATDLIKPAAMVNVLGEDDYTGAARYEGLHELMAIPGVHLHLYGKKITKPFRKMGHITITDENTITLKEKALQVKEILKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F8</accession>
    <name>A0A654E3F8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protease YugP</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yugP</name>
        <name evidence="2" type="ORF">MARINOS108_20809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="25367" checksum="37D6793FCE87A686" modified="2020-04-22" version="1">MLFIIIIGFMIASLVVSTRLKNKFKKYSKIPLSTGLTGREIAELMLADHGIHDVKVMSVQGQLTDHYNPTNKTVNLSPDVYNGRSAAAAAVASHECGHAVQHATAYSFLEFRSAMVPIQNISGQIINVVFMMMFFGAFLLPSIIPFNLAILVIIACYGVFTLFAFITLPVEFDASKRALAWIQDRNIVNTGEHKMAKDALDTAAKTYVIAALSALATLLYWVMIYLGGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G6</accession>
    <name>A0A654E3G6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="29230" checksum="EEC6C0D64979F49E" modified="2020-04-22" version="1">MIHIAIVEDERLSAERLKVLVQELSPEYSVVALLDSVESTIQWLKDNSSPDLILLDIQLNDGVGFDLLADDLISCPVIFTTAYDEYAVKAFKYNSIDYLLKPIDRAELENALEKFKKYGERTVSPEVKDQFGQVSRMLSGSYKKRFLVKLGDRFQPFTVEDIAYFVSQNDLTCLVTRSGDKWPMDQSLDQLQELINPLDFFRINRKLIISLPAIKEIHSYFNSRLVLKLDPHADDEVIVSRERVANFKRWMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3H7</accession>
    <name>A0A654E3H7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="3">
        <location>
            <begin position="686"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="785"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="974" mass="112116" checksum="5BB16C1374C7D615" modified="2020-04-22" version="1">MLLWGLICGQIAYGQIGNKGVPNIRNFTYDEYQAGAQNWSILQDDQGRMLFGNNYGLLEYNGRDWSLITQPTNKTVVWSIYKGRDSTIYIGAQNEFGYLKINNAGQKRYISLLSKVPEDSREFSDIWAILETSSGIHFHARGAVYIYKDDTINVIKTPMIDGFSKIGDSILVQDRSFNIYVVKPTGLRKVISGADVQGTVLRIFDNHHGGLQLVTQDHGILTFENGKIVPEKHISSAFMQGHKIQCLYKLRNDYLAVGTVGAGLLILDDAFRPIQWLNKSNGLQSNTILAIGSDHIGNLWVATETGIDYVQTAIPLYKIADNYELEGTVSSTLIHNDKLYVGTNSGVFYTEWNDQENPLTPTLHFKQIKGLSGQVWNLHLIDGQIYVCQHEGLYRIEGSSAIRIFEGTGVWNLIPIREGNPKYYLQGAYDGIHLFELSDGDFRYLRKIEGFEETSRIIELDDKNNIWMAHGYKGIYRLRLDQAMKRFAEVKLYKKEHGFPTSLFVNLFKVKNQVLFGTERGTYQYDYALDTMVADPLYTRILGNTQHIRLLKEDDGKIWYIKGQDMHDEMGIIDFYDNEKYEVTKAPLQHLQGRFNPGFENINSLSQNAVLFGTKNGIVLFDRTVNRNYAKPYLASITEVRCVTNDSLLYGQLPIDQQKPISDHVDPPLLRYDQNAIRFYYASDYFESPDQTSYSYYLEGFDKSWFTGEHELSKTYTNLPAGEYIFRVKATNVYGFESKEAHYSFKVLPPWYLTTMAKVAYVITFLLIGVGLMKLYRKRIENAQKKERLAQMDVLQRNREEYNAEKLLTEQELITLKNEKLEAEIAISRSKMDVLNAEMAASIMMITQKNGVLIKVREDLESLLKKAKDSNKELIQRVIKHINQDIDTDQDWRQFKIHFDKVHEDFLERLKCQFPDITPKDLQLAAYLRLNLSSKEIASMMNITIRSIEGCRYRLRKHLNLSSETNLSEFIIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R9</accession>
    <name>A0A654E3R9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="31249" checksum="EFB8787C64ED0553" modified="2020-04-22" version="1">MKNEYLDTLGLQPGATKAEVKAAYRRLSKIHHPDISKDPNAKEKFIEINEAYNFLTKVGPTPHQETVSYNYNPYVSEYDQWRKEARRRAWQKAKEQERMQQEMIVKILKGFNIVALIIFLTNVMLIVDYILPKKEETQEILSIYRVYESGRHIKKTYRYDEIHFETVTMLFDRGEVTTLKDLGPTGRVITTRLFHTPIAAYISIAGNEERHEQIYSIYRVFGFLIPAILLFLALYRYAVTSLDPKLTLALFLLAFFMIQLWILLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3T6</accession>
    <name>A0A654E3T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="34682" checksum="A025F334D19CAF4D" modified="2020-04-22" version="1">MSGVPEISVIIPVFNREISIVRAVKSVIKQSYENWECLIIDDGSTDSTLERVRTEFSTDPRFKIIERPKTRIKGGGTCRNIGIEMAIGKYIAFLDSDDEWEPNKLMRQREFIRKLNSEKVVIYCQAKIFRKHHTIVLPSFEKSHMTPVEKYLFLEKGLMQTSTFFLHRHFAKKILFDENLARHQDYQFVITAEEVGACFRLIEDSLVKVYWNEDYNLEKRGWSPDVSYSFANQYLKNQMIKEVFIGRNILNACILNKMYVEALNIFVKYTYKRLHFYDFITMIKLLLLGLLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U3</accession>
    <name>A0A654E3U3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024974333" evidence="2">
        <location>
            <begin position="21"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="784" mass="86252" checksum="CC7D3FBFB6D8CB7D" modified="2020-04-22" version="1">MKFIISICFVLLVSITPVWAQPFKIGVISDFDKSPNLEAIINQMIQEIDQTTGASREVSLGSTSFGIVDIESAQRSYDQLDGQVDLVIVLGSISAKSLSLMNDLPIPVIALGIVDPKLQEIPYVNGTSGKRNFTYIWSTRNLEKELEVFHQIHDFNRVVVLVDEKAVSTINEQKARNLIDSLSKKLNTRLSIIPVGTDIAQTLSQLPAATDAVYFTVLLSQTESEIQLLINQLNERKIPTFSGNARLLDYGVLGSMANENDLQQVIRKLAIMADGIASGSDLSSLPVTLDTEENLYVNIGTARKIQLPIPFEVLFTATIIGDKEGAVTSYSFEEIAEKSLASNLSIQISYQDIARSNVRVKSARSNVLPSIESGLTASQINEERANAAFNAPEQSLTAGLTFTQLIYSEKAIAAIKIAKYLEKAQAYNTEADVLSVLFDTYTAYLNVLSAKTNVLIQRENLSNTRKNKELATIRVNLGSSNNTDLYRWESELAFANQSVIEAQTTLLAAKLQLNTLVANSLEPEYDIEDISLNGDLYKALSQGPLADVAKTPESLRVISDFLVMESQQQNPNKKALVENVNAANRQLTQNKRILYIPTVAIQAQTSQILGRSGVGSTLDASAMALGVTELQDNSWFAGISLTFPIFDGFGRKAAIQQSKISLDQLGYSQTLLDQSLELGVRAGVLHVLSTSTNIRFSQSASESAHKNFELVQENYKQGQVTITQLIDAQQTALQAELAAAFSIYEYIQAHLQLEFNVGSFITLTPEDQVQDFNNRFQQYLINQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X4</accession>
    <name>A0A654E3X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043727">
        <property type="entry name" value="DUF5670"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18919">
        <property type="entry name" value="DUF5670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5279" checksum="1BC9DFF7304B3603" modified="2020-04-22" version="1">MRSLLYLIAVILVIGWLLGFFVYSLGGLIHILLIIAVISLLLGVIKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E415</accession>
    <name>A0A654E415_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC</name>
        <name evidence="8" type="ORF">MARINOS108_120232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="447" mass="49110" checksum="73CC063E1F3F8E36" modified="2020-04-22" version="1">MFDKILIANRGEIALRIIRTCKEMGIKTVAVYSTADADSLHVRFADEAVCIGPPASKDSYLKIPQIISAAEITNADAIHPGYGFLAENAEFSKVCEEYGIKFIGASADMINAMGDKATAKATMKAAGVPTIPGSDGLLESMEQGMKLAEEAGYPVMLKATAGGGGKGMRYVKDKSGFKKAWDDARQEAGASFGNDGLYLEKFVEEPRHIEIQIVGDSRGRACHLSERDCSIQRRHQKLIEETPSPIVTQELREKMGQAAIKGAEAIGYEGAGTVEFLVDKYGDFFFMEMNTRIQVEHPITEEVTDFDLIKEQIKVAAGVEVSGRNYYPQLHSIECRINAEDPANGFRPSPGKITNLHFPGGHGVRVDSHVYAGYVIPPFYDSMIGKLIVSGQTREEAIVRMKRALQEMVIEGVKTTIPFHIRLMDDPVFKSGKFTTKFLDDFDFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B7</accession>
    <name>A0A654E4B7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024823367" description="Peptidase_S8 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="2">
        <location>
            <begin position="160"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="855" mass="93912" checksum="6B135863E32A13BF" modified="2020-04-22" version="1">MKWLFWVLLVSLMCVNTVLAQSKLSPKLIEESQRRAHLSTMDTFTIAVQNRPLFVRQYGGRVKILTWHSASSTLTFYATQSLIFGELIEDENILFIDAPDQPREESVLDVPNFQYNRIRKAQHQYPDNSGSGLRLSLKERKFDEADIDLTGNTFSIGLEAEDVSQHATDMATIILGAGNTSPFYKGIAPGALVASSDFNNLLPDDETVLTQNGIYLQNHSYGVGIENYYGVEAYAYDQSIFSEPEIVHVFSAGNAGTSSPEDGTYSGLSFANLTGTFKQAKNTLIVSAVDTSLAISPYNSRGPAFDGRIKPELTAYGGGGTSDAAAIVSGIVTLLQESFQKKTLHLPSSALIKTVLIAGAEDIGPEGIDFYSGYGSANASKSLQILESGWHDEVVVTKGENTTLEIEIPTGVKQIKLAVSWVDPAAELNVTRALINDVDAQLSHGGATWLPWVLNHSPSEAALNEPPQRAMDHLNNVEFISLESPEAGTYHLELSGANLSSASQEVSVAWYFEMADTFEWDFPTSSDILAANTAEWLSWNSTFNANEGLMAYQLNDGEWVDIGTVKLNEPFRWATPKISAAARLKMTVGVNEFVSNNFSISELPKVSVAFNCEETFGLQWPQIEAAQSYEVYEMGATSLHLIGTTTDTIYTIEKSASVYYSVAPVIGNAGGLRSQALNYTFQGTFCYFNFFAAERANEETVRITLNLSTSANIEHVEVLKSVNASEELLTDIVPEGQTSFVLSDPDLDPGLMTYQAILYFKDGTTLRSDESSLYIEIPGKLLLFPNPATDPYINLLSSGNGQLLQITDDQGKLVLEKKLVESFEYIIVQDFREGLYLYRLLEGKKVVDTGKFIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4C1</accession>
    <name>A0A654E4C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8697" checksum="07EEAB5357BAE02D" modified="2020-04-22" version="1">MYWTLELASYLEDAPWPASKDELIDFSIRSGAPLEVVENLQELEDDGQPYENIEEIWPDYPTKEDFFFNEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F1</accession>
    <name>A0A654E4F1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific DNA-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_60065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="80"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="544" mass="62414" checksum="3D0F0905B3A82B2B" modified="2020-04-22" version="1">MPTLHWIGKEKVINHHRDVPYKVMEHQYRFEAVTANEGKQSGEIASQARDDGNDHSGNKIIHGDNLEALKSLLPEYEGKIKCIYIDPPYNTGNEGWVYNDNVNDPKMKKWLGEVVGKESEDLSRHDKWLCMMYPRLKLLHKLLAQDGAIFISLDDNASFFCVPMMNEIFGSNNFVTSVIWEKADSPRNSARQFSTDHDFILVYSKSPEWIPNKLPRTDKSNSIYTNPDNDRRGLWIPGDPYANKPYSKGEYEITGPTGRRFSPPKGRYWRVSEKKLKELDKDGRVWWGPTNNARPSIKRYLNEVSDLVPRTLWKKDEVGSNRTSKNEIRSIFPESSSFDTPKPIELIERVLQIASDKNAIILDSFAGSGTTAHAVLNLNKQDGGHRKFILVEMEDYAETITAERVRRVMNGYGEGTKAVEGTGGSFDYYTLGQPIFLEDGLLNEAIGVDKIREYVWYSETKSPLLGAAREGEDEAYFLGSAHDTAYYFYYEPDQITVLDTDFLRTLQTKADQYIIYADKCLLDESLMQKYHIVFKKIPRDITRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L9</accession>
    <name>A0A654E4L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_60128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="21721" checksum="6D76AB1BBE8D4F84" modified="2020-04-22" version="1">MKNIKGQVIAVMMIITASLYSCRQDTIVTSVDPDVQLKADLKVMEAYVNAKGYTDVDTTESGVWYVVLDSGNGAGINHNDIVSFFIAGRLTDGFLFATNIDTVDINNGTYDEDLTYNPIIYTYTADGWNIPEIITNFYSYERGYREGLSKVLGILKVGGRAQIIIPSGLAYSTNPPFGLGIPRNAVLVFDIYPSYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U7</accession>
    <name>A0A654E4U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="91" mass="10836" checksum="0698873B2D1DFA01" modified="2020-04-22" version="1">MLKTYTEVSANVWCTIRRERIKDHHFIRYFLHTPNATLDVLRFVVGNDDGGELHFIPFRNPEDTSGCKYRERKLMSTEVTPFCWVNKFILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V4</accession>
    <name>A0A654E4V4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="26592" checksum="721FD7128740083C" modified="2020-04-22" version="1">MENSEALIKTVGLKKFYYTDEIETTALAGVNLEVKKGEFVAIMGPSGCGKSTLLNIVGLLDNPSEGEFHFTDQEISTYSERKRAELRKANIGFVFQSFNLIDELTVYENIELPLIYLKYSSSERKKRVEEVMEQMKIMHRRNHFPQQLSGGQQQRVAISRAVVAKPKLILADEPTGNLDSANGQEVMNLLTELNENGTTVVMVTHSPLDAEYAHRVIHLFDGQIVSENMNAKDNALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E525</accession>
    <name>A0A654E525_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycogen debranching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="367"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="782" mass="87384" checksum="F0C725627AEE3A94" modified="2020-04-22" version="1">MKTIFPTLLILLVGCSSPSPTESFEGILTDLPSMPGKSEYLGTPYVTAGDRLYSVGHQDGSFPDLGWHVTGEMGGIWDHPIKLMDGFTLGISAGSMYYCLNDAQEFINFPMANQHRFYPSEAIAVIRTQFVPDQKEGMIIEYVLKNTGDEALNLKVDFTGMVDLRPVWLAERLNQTDGQDLADFDEVNGTWAARDSLNSWHTVFGSDQQVSAWSQPKTECSDERKGKGIDLTLQSEITIPPGEQKVLKYFISGSYKSQAQALETYKELKQSPNSLLQQKMDRYSELANTARLTIPDQEIEAMYTWTKYNTDWLMRDVANQGRGLSAGIPDYPWWFGTDNTYALQGLLATGAHEEVKATIELLLKLSESVNDNGRIMHEASTNGVVFNPGNLNTTPYFIHLLWKYYQWTGDTDMLRKTYPTVQKGLQWLEQEDKDGNGYPDGAGMMEIHGLHSEMIDVVVYTQAAYDAASKMANALGDSSASKSYQQKAELLSKKINDEWWVPSAGSFADFRATRVETLQLIDAAIVRADTIQKPWAVEELKQLKAQVGRLRDNRVQSQVVHHNWVVNTPMELGIADVDKAEQALETARKYTNPFGMYVTGIDRDENQGKASKWKSFSYVGAVMTLPTGVQAISEARYGHPDASLDYLKKLANGFGYALPGSMYEVSPDYGMIVQAWNIYAVATPIVAHYFGLKPEAYNQTVTFEPHFPTGWDDVKLENILVGDNLISFEKTKSGFTITQTQPEWKILLISPELQKSTLVNGQPAELSSTTLVLTGLRNEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E528</accession>
    <name>A0A654E528_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TonB-dependent receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="727" mass="81044" checksum="B7B3CA43FD79D6A0" modified="2020-04-22" version="1">MKYWIGGLMAIIGVELGAQTVSGTVYDQMSNTPLPGATISVSGTLTGVAADENGFYELTDLEPGHYRLLVSYVGYTGKTLSEVWVKTGVVTRLDVYLERNSSSLDEVIVTTNISITEPGKIGITEEQINRFAATYYDPARLVTSSPDVAVTNDQNNQISVRGISPNYNTWRLEGAEIVNPNHLSNAGTFLDQPSATGGGVNMLSAQMLSQSQFLYSTFDSRYSNSVGGVFDMNLKNGNTTQRQYTAQASLIGLDLATEGPFREGGKMTYAANYRYSFTGLLTQFGVDFGGESIGFQDLSLNVSTPLGTRSRLKVFGTGGLSFNNFDHKPMAESEVIKDRRDIYYDNKTGVIGASLKSGFDNSHLTTSVVLSGYENTRDQYGYDDNDVQDTSLIQHNSQRILSMHSSYERSVGGANVTLGVLANQYHWTGSLQGIFDHSLNQFLINPYAQVEWYIFSDLKVKAGVNYNQSADDSSIDPRISLTQQLNANNSFILAGGKYSQLTNPYNSDFVSFYGGQRWGEIYELLKSYRGTLTHVYEKRGFNVQSEFFGYYYPSVIALGERTAWTFGGTLTSEKSFSDGLYFRLGGSLFESEIEGFVIQPYNTRYNMSMAAGKEWDVSKGTKNRRLGLNLRGQYQGGFYYSENIPTTDGSMSGYSRFDYRTAPYLRFDVRLLWTRYRENRTTSIALDLQNASGVQNEGYKYFDGFTNQLETQYQLGLIPILTYRVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E594</accession>
    <name>A0A654E594_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="247"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="362"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1215" mass="135321" checksum="4F2B8D677ADFE3E2" modified="2020-04-22" version="1">MKKLIYFSLLIGAMSACQERKEIERPREAWVFRSVLDLKPRMVTAALSEDVWVAYDARTASLYKAWKGGVNFDGAVYTTVHGPQPTSKGYAYYTDEKEDVEWVLKKGDEILTPKVQYKGHRFVDGQVVFTYELSTDDNKITVEETPEAIRRGSQSGLSRKFKVSNAGDYQVVLNTTISSLVSERDFNTNGSFEVISKSNQEYPEGNVVSVVGVLTLSQGEPTELRAFYHEGFDKGLPVVTEESEEASGVGAGAQLIERSDCKSCHNEQVKTVGPAYISVARKYSDGEESVKMLSGKVIKGGSGVWGEAMMTPHAGLSEEDAAEMIRYILSLDDNDEDSDGGAWHLGEKTVPVKFQDEVNISSESPGVAAYLYLYSGDQPNFNTLKKEALPIGGAIVPQVHVRDESDFGERTQRIAVLFKGNLRIEKTASYSLRLVSDDGSRLFVDNKIAIDHGGFHGPTPKDGEVYLTAGDHPFEIQYFQAGGGGAVSFQWFNKDVGKFEVIPQSMLFVSPSDYLETKEYISDEVLVKSIPGDGRWLAGVHPAFDIFQARPDDFRPRVGGIDFLSEDEMLVCTWDSLGPVYLVKNFRSTNPEEITVQRIATGLAEPLGIKVVDGEIYVLQKQELTKLIDNDKDGLIDEYQTIADDWTVSANFHEFSFGLVYKDGYFYGALATDILPGGASAQPQPKDRGKIIKIAKETGAVEFIASGLRTPNGIGIGVDGEIFVADNQGDWLPASKINHVREGAWYGSRSVDPEGTEGWVQDEPVVWLPQDEIGNSPSTPLAIDKGPYTGQMIHCEVTHGGIKRVAVEKVDGIYQGAVFRFSQGIEAGVNRLAWAPDGSLIAGGIGVSGNWGQTGKLNYGLQRLVYNGNSAFEMLKVSARSNGFEIEFTEPIKVGQNISVEDFLIEQFYFKPTAEYGGPKLDVTEMKPKNFYLSTDRKKVFFELEGLQEKHVVYFRIKRPFVSELDHELWTTEAWYTLTNIPEGLPGFTNDYKVTHNVLSEAEKAQGWKLLFDGKTTQGLRNYKVETLGKKWQAVNGTLHFSGKGSGAGWQAEDGGDIIITDKPYKNYEFQIDWKMSDGGNSGIIYNVVEDDQYDYVWHTGPEYQLLDNLKHPDGQIEKHRSGDLYDMIKTKFVTVNPTGEWNRTRIKVNNGHVEHWLNGYKVVEFDFWTPEWDALVAGSKFSEMEAFGTGKEGHISLQDHGDKVWFRNIKIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B8</accession>
    <name>A0A654E5B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="90" mass="9913" checksum="BB885AA40B72ECB5" modified="2020-04-22" version="1">MSASKTLFTFITGVASGLALAYYADPKGSQQKLKKIEKDLKKTRKTLDKKLTEYKTTYNDMVETYATKSKGLIDNAKGLVDGAKKSVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5H2</accession>
    <name>A0A654E5H2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transporter subunit: ATP-binding component of ABC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybbA</name>
        <name evidence="5" type="ORF">MARINOS108_140159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="221" mass="24292" checksum="FC31F2A73F770290" modified="2020-04-22" version="1">MSTILQVESLTKTFQSGHRQIKVLDNINFTIAEGQSMSIVGPSGSGKTTLLGLCAGLDRATEGRILINQVLLNQLSEDELAQLRNQQVGFIFQNFQLIPTLTALENVMVPLELRGEKNITSASKELLNRVGLSDRLDHYPSQLSGGEQQRVAIARAFSNRPKILFADEPTGNLDEETSHSIESLLFELNREQGTTLVIVTHDPDLAQKTDSIIKLKGGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5L8</accession>
    <name>A0A654E5L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipopolysaccharide export system protein LptA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_90147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13100">
        <property type="entry name" value="OstA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024845099" evidence="2">
        <location>
            <begin position="24"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="4">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="3">
        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD21509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="586" mass="67349" checksum="3C76D4B08D5A2D93" modified="2020-04-22" version="1">MFKILQYYIFLVIILCLSTVAQAQKGERIKYKAEELEYGKKKDESYRKLTGDVVFTQKSTTVYCDTSYFYKKRNVMEATGHVRIVDDSTTITSRQLVYEGDERMAKLRQNVVYLRGERELYTDFLDYDLEGEIAHYFNKGKLIDTTNVLTSEIGYYFAKDEFAQFYKNVVLTSPDFVLKTDTLRYNTLTKVAYTYGPTQITSDDGTVLHAKGGEFRTVVDESDFVKGSIETRDYYLEGDELYFDDGEKYYKAVFNVKMTAKDEDVIITGDEGYYDRRNGISKVYGRPLMKRILEADTLYLAADTLVAIESKYDSAKRILAYKNVKIYKEGLQGIADSMAYFNEDSVIFFYGDPVMWNNQNQITADTINLEISEDEMKRMNLRSDAFLVSEDSIENYNQIKGRNMIAHFVDNQIDRINVNGNGEILYFALEEGDSVLMGMNKIFCASMQIRFKEQKLSSFSVYTNPEAQFIPPHELTEEMQYLANFAWRETERPTLFEIAPYLNPDYEFIPVEVNPDDIGGIQSESQHKSYTPTQNTKPKNTPVRSLNPTSSSSVNTPTSAEPNTVKKSINKTNKNLKAVDDDGSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E634</accession>
    <name>A0A654E634_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025070133" evidence="1">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="26233" checksum="BE2C9B8A3E5B5112" modified="2020-04-22" version="1">MVNKGLLVFLMASVLSGAQAQNSDFFVEILGGAGVGWSEMEETFINGEDDKTYVLTEGTGVGSKSLGVLVGKALGQSVFTILAGVEVQQTGGKYIFSSGHFYWNTDKAEWDIASGEIRKLQQDLVRLQFPVIIRADVGSGFQLSFSVFPSFNIKHRDKAWESAMELSPDFRFEEDFDASGRFSLGVIKALDSNFALSVSWTGDFQGREFLEVDQNVVTVSPAYQNVQLHLHINCSAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6L7</accession>
    <name>A0A654E6L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="7993" checksum="5F1C1F3AAFEF2529" modified="2020-04-22" version="1">MIIDIVLCILLYCVLLVFIFWKNNHNKNNDSDGDDEGGLPVSLPPDIDLPPGICLPDDLPKKSIPETEEVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6X2</accession>
    <name>A0A654E6X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023293">
        <property type="entry name" value="dGTP_triP_hydro_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027432">
        <property type="entry name" value="dGTP_triphosphohydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="58"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="450" mass="50943" checksum="8F8A774B47635E79" modified="2020-04-22" version="1">MNWLQLLSPKRFGDKTEATISKDSRSRFEQDYDRLIFSHPFRKLQDKTQVFPLPEDDFVHTRLTHSLEVSSVGRSLGKAVGERLLEKHPELSERGFTFYDFGGIVAAASLAHDLGNPPFGHSGESAISSFFTDHPKGKAFQQQVDPAEWSDLISFEGNAQGFRILNDEENSALRLTFASLGAFTKYPRSSSAPKDKNRKSQKKYGFYKSDSKKFSELATEMRLTPIGEAAWCRHPLTFLVEAADDICYNIIDLEDGCRLGLVPYETTRDLMAAIIGEKYQQEKLERSRNVNQKIGLLRALAISQLIGECVDLFLEKEEDIRSGAFDGALTEHIPSAEALQAITTLSIEKIYRSKQVLEREAGGFEVIGKLMEAFCMATYHKFFDKENYTPRMKSIFRLLPDSFQDKLEQEPITIYDSLLIVMDFISSLTDSHAIKLYKTIYGFSLPVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E730</accession>
    <name>A0A654E730_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SusD-like starch-binding protein associating with outer membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024894156" evidence="5">
        <location>
            <begin position="22"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="92"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="271"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="557" mass="62018" checksum="7E370E5DDAF7311F" modified="2020-04-22" version="1">MKRAIKFYIATVLIFAMSSCGEQFLEVLPEDNPVLDGFYQNKEQIRTVTATLYGRPWFNFNDKFSWAAGDGLSGDMYQDYQDEGQFFFFTFTPANSIVSNSWASLYSIIARTNVILADMPRIAGGYGVPEADINAGLAEARFFRGMAYYFLAEYWGDVPIVEDPASIIAGGDYKLPRNTYKSVLQYTANDFAYAAEHLPTSDSPGRVTSWSAKGMLAKVKLTQASDLSDPNSSANFAEAAALAKDVIQNSDYALMANYEDLFKPENDNNSESLFALQWISGAWGTGNSRQAVFARSSIITGNSEAWGGGKSMTYDYVRAMDANDGNLDSVILDKRQPWIFMSVGDFYPDMNTDEGGYLYEIVSRDEDGNQLEYKSPVCNNIKKYVVGSQDDIGASVINQASPLNQYMLRMADVYLIFAEATLGAAGSTTNSEALGYFNEIRARAGLNPRTSISFLDILTERRMEFGAEGINWFDVKRFYRRSPSEALDYLNDQERAYRVEAIDGATQADENNPAFYEVVEPDSPVVISAADMELPVPENEVVANPRLSEEPVEWIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7Y3</accession>
    <name>A0A654E7Y3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="10" type="ORF">MARINOS108_12007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="22608" checksum="BB3D8D4241BB1115" modified="2020-04-22" version="1">MSNSIYSEDSSEKVEKDFTLSVLTEDKAGLLNHITIIFTRRKMNIISLNVSTTEVAGVSRFTIVLHSTRETIEKVVKQIRKLIDVLGAFVYEDHEIYYQEIALYKVPTKVFLNGSKIEDLVRNSGARILVIEEDHIIIEKTGHKKDTHDLYKKLEPHGLLEFVRSGRVAISKSKRKTEAYIKQLEDAPSHYLSIKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8N8</accession>
    <name>A0A654E8N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_110047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016944">
        <property type="entry name" value="UCP030066"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030066">
        <property type="entry name" value="UCP030066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="13822" checksum="8ACCFBC5C790DFA8" modified="2020-04-22" version="1">MKKDKIIYWATTGIISLMMLFAAFSYFTDENVKNAMSTHLGFPDYFRVELGIAKVLGALALILPMVPTRLKEFAYFGFALTFVSAFYAHLSSGDPLAASIGPIVFLGVLAVSYVYFQKRTSLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAP7</accession>
    <name>A0A654EAP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF RNA polymerase sigma factor SigH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigH</name>
        <name evidence="4" type="ORF">MARINOS108_120521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22915" checksum="AD8827CA0F7BE668" modified="2020-04-22" version="1">MSEEQVIRRKYSDKERKNIFDNEFLPHLDAMYNFAYRLTFDQDDAKDLVQDTFMKAYRFINSFQQGTNAKAWLYRILKNSFINDFRKRSKQPAKVDYQEVENFYNSEDVDESRTVDLRIDAVKDMIGDEVSNALNALAVDFRTVIILCDLEGFTYEEMAKILDIPIGTVRSRLHRARNLLKEKLKSYALTMGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBA3</accession>
    <name>A0A654EBA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="313"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="416" mass="46248" checksum="81E634A0BBB810C1" modified="2020-04-22" version="1">MFDLDKWQEIFQTITKNKVRTFATAFGVFWGILMLILLLGAGQGLQNGVQQSMLLDAINSIWVIPARTSISYEGMPAGRQHPFQEEDLESVFTEVSGIEFMSPENWLMGNYIVKYKNRGSAFGVYGTKSDYFDIKVTMKIQSGRSLNLLDDREKRKVCYIGNRVAESIFPEGVDPVGEYLDIKGSMFRVVGVFKFEASNGMDQAQRIYVPFSTYQQIFNPDKSVSLFAVTTAPGTMGKQLEGDILELLKIRQSIHPDDDQAFWVHNQEENFRQVQNLFNGIKAFIWLVGIGTLTAGIVGVSNIMIIVVKERTKEIGIRKAMGATPNSIVGLILQESIFITAVAGYFGLFMGVVLLESVNYALEAMGADLDFFTRPEVNFRAAITSLIILVVSGALAGLFPALRAAHIKPVDALKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECE5</accession>
    <name>A0A654ECE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="25692" checksum="FAF857F1EDD89CDC" modified="2020-04-22" version="1">MAKTKTKKEEGIEFLEDPDVLASKAEEFFNSKRNKTLVFGVGGVLAALVAVFLIYRFYITNQNLEAQEEMFQAVYYFEADSLGKALNGDGINYGFLDIIEDYSGTDAANLSSFYAGATYLKMGDYSSALRYLSDFSSGDYLVQARAYSLMGDAHMELEDYSSASSAYQKAANYKSNEQYSPIYLQKAAIAQENNGDFAAAAKSYGKIVDEFPNSSLVQEAKKQKARLQGLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED18</accession>
    <name>A0A654ED18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod shape determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="422" mass="46672" checksum="BC831C377D692BFA" modified="2020-04-22" version="1">MRNDQLINKLDWQVILIYLILVFGGWLNIYAADYDPDVNNGILNFSMSSGKQLIWIGSSFLLIALIMLLDFRFYDSFAYIIYGILIFLLIVVLILGKEVAGSKSWFELGAFKFQPAEFTKFAAALGLAKYLSKSTRKSSDLKVQSIGFLFIGLPMILIILQGDLGSAMVFGSLILVMFREGMHPLILILGLGVIILFLLTLLVSQTVLLIGIVVVTLLALGLVAKSPPKIAIVLIAGLLTAGFIRSVDFILTDVLKPHQQKRVMSLINPNADPLGVGWNVTQSKIAIGSGGLTGKGYLEGTQTKFDFVPEQTTDFIFCTIGEEQGWIGSFLLVALFSTLFVRLIYLAERQKSSFARIYGYGVASILFFHFAVNIAMTIGLFPVIGIPLPFFSYGGSSLWGFSILLFSFLKLDAHRMQVLQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEC4</accession>
    <name>A0A654EEC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="10838" checksum="85EB2430A22E4839" modified="2020-04-22" version="1">MNEPVHITPKAQKEIKHIMANKNIPEGYGLRVGVKGGGCGVTFVLGFDKQKENDQAYEIAGIPVYIQKREMMFLLGKEVDFYDGADARGFVFVTPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSP3</accession>
    <name>A0A654DSP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="20701" checksum="45C4F349F986AF9A" modified="2020-04-22" version="1">MVENMHLPIQAIWKDLHLELDKFINSKVNDPELSKDLLQEVFIKVHKKVHTLRSTERLTSWVYQVTRNTISDHFRKENKHLKTELPLLLAETPEDEPLYARLANCVNSKIAQLPPKYRDAVLLTSFQDLSQQQLADTLDISLSGAKSRVQRARQQLKEALLNCDNLESTNAGRPIDYSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSQ3</accession>
    <name>A0A654DSQ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="266" mass="30745" checksum="3DF2848F62161F10" modified="2020-04-22" version="1">MKKMLVGIFVYFLFQISGDCQKCADIKLKNSDVFLNVSIAATSSTQFYTNEGSDFKFEAIDSVILFFEPSESLVSHLENKGVSFTIKRMSLEEIEEVTGENIKTSLDWIILTSGDSLHGYIEEKSNGIIFRNPIESDFRKISNTDIISYKNNEVIYENFRGMKALEIRGNVSLYIDTLRATYVHFSPYGARAKPTTSIYYFVKRENEEELMLLSIKGKIWLNSTFKKTATNYFKECPDLVDRINRGWYTKNHIVEIVQFYNTRCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSY5</accession>
    <name>A0A654DSY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-xylosidase / Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.37</ecNumber>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xsa</name>
        <name evidence="4" type="ORF">MARINOS108_10202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="4"/>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="366" mass="40616" checksum="E1657A47D1A8D88B" modified="2020-04-22" version="1">MLNSTLNSAIYILGGTLLVMGCQPVKEKNTTSDAALSDTTALPVGISEPLVTDLYTADPSAHVFDGKIYIYPSHDIESGIPEDDLGSHFDMKDYHVYSMESVDGPVIDNGVALDIKDVPWAGRQMWAPDAASKDGKYYLYFPVKDKNDVFAIGVAVSDTPTGPFQAEPAPIEGSFSIDPAVFQDEDGTFYMYFGGIWGGQLQKWRTGTYDPEGELPGKDEPALLPKIARLADDMKSFAEAPRDVQILDAEGNLFLEGNNEQRFFEAAWVHKYNGKYYFSYSTGDTHNIAYAIGDNPYGPFTYQGLVLKPVLGWTNHHSIVEFQGKWYLFYHDSSLSGGRTFLRSIKMTELTYNEDGTIQTIDAYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT74</accession>
    <name>A0A654DT74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="262"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="420"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="905" mass="101422" checksum="485E9696075D0F28" modified="2020-04-22" version="1">MPLFSVSTSQPMPRILLSGLLLFSLGLHAQKIADFRFSYDPVGQSLPTLIHQAESNFPVTVFYKKAWIDSIRAVSVPDNKFLSILQASLSNSGFRITIKDDYYLFIYPDDELITGLGINPFEEAQVKETWVEIGDQAKMQPGVPTKLTGYVSDATGEVIPGVTISVDDGSSGTISSPLGYYQLELLPGNHAITYNYLGFESEQKKIKLYSQGTLNINLYEETSVLEEITVEEGGARDRLTNTSLGKSDLSIYAINKMPAFMGESDVIKSITILPGVSVTGESSSYISVRGGNYDQNLILMNDIPIYNPSHLLGFFSVFNPDMVSKVSLYKGSVPARYESRASSVLDVKLSPRASSPFMAYGGIGILTSSLGAKGKVLDDKLTYTVGSRATYSDWVLNAVPDKDAKTSAANFWDFNSVIEYQVNSKNSVKGTFYKAKDSFQFSEDTTYSYDQVGFSLAWNHLFSNDLLYNLTVSHSDYQYETEGDAQNYQFLLKNGIQQSGIQNNLTFSRGMHALEAGVHLNRFITSPGSMEPNSQNSLVVPTTLSEEHAVTVSGYLEDEVKLTESLRARVGLRYTNYQLLGPLTTYTYAPDSPRNETTTTGEISYDQNEKIANYHGMEPRASISYLFPWATLKLGYNRLYQFQHLISNSISITPLDQWKLSDQFIKPVISDQLALGVFRNFQENTLEASVEGYVKHYQNLIEYKNGANIVLNESLEQVLISGEGKAWGLEFLLAKNKGRTQGWFSYAYSRTFIRTQSPHVEERINDGAWYPYYSDRPHNISLSLDHKITNRWSMGVNFKYASGRPVSAPAARFVVDNVTVAYFNERNGERIPDYHRADISLTHENKVKKNQQFRSKWVISVYNLYARKNAYSIFFKNSPGAPAQPYKLTIAGGMIPSLTYKFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTD0</accession>
    <name>A0A654DTD0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein MARINOS108_10335</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="11845" checksum="BE64A64E053B3F8E" modified="2020-04-22" version="1">MLDMMKMMGKLKEVQENMKAAQAGLKNITASAESGAGMVKATVNGNKEVTALEIDESIISKEDADMMKDLIIAAINKAMVEVDAASKEHMKKATEGMIPNIPGFDLNNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU99</accession>
    <name>A0A654DU99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="47259" checksum="91CE9F00CEB6905A" modified="2020-04-22" version="1">MRPESLMMSYGYRPELSEGAVKPPIFQTSTFVFKSAEEGKAFFEVAYGLREKHEGEELGLIYSRLNNPDLEILENRLSLWDGAEDCAVFESGMSAITSTLFEFLKPGDLLLHSAPIYGGTDHFIRKILCQYGIHTLEFRPGESQQQIIDRIGSAEGRLKMVYIETPANPTNALIDIEMCRRVGDHFAGEDHQVILAVDNTYMGPLWSHPLKHGADLVLYSATKYIGGHSDVVAGACLGSKQLMARVKGFRTFVGNMAGPWTSWLLMRSLETLKVRMDQQASNAAILAQRLADHPKVEKVYYLGLLKEDHPEYAIYKRQYSSPGAMLSFDIKGVEEDAFTVLNHLKLIKLAVSLGSTESLAQHPYSMTHADVDRDLKNALGLTEKMVRLSVGVEHVDDIWSDLVQALEHVGQSSSKTSKMSMTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUC0</accession>
    <name>A0A654DUC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein Thx (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bTHX family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030826">
        <property type="entry name" value="Ribo_THX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031414">
        <property type="entry name" value="Thx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17070">
        <property type="entry name" value="Thx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04560">
        <property type="entry name" value="ribo_THX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4285" checksum="4613A276F113DC60" modified="2020-04-22" version="1">MGKGDRKTRRGKIAKGTYGVRRPKNTTGKAEAPKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUE9</accession>
    <name>A0A654DUE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase (NADPH) small chain</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">MARINOS108_10343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="144"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD10982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="491" mass="53775" checksum="E0DD194DA786F902" modified="2020-04-22" version="1">MGAVDGFLKYNRELPEVRDPKSRIADYNEIYVPFAEEKTNKQAARCMDCGIPFCHNGCPLGNHIPDFNDAVFNKDWETAFKILSSTNNFPEFTGRICPAPCEGSCVLGINKDPVAIELIEKSIAEEAFERGLVKANPPKTRTGKSVAVIGSGPAGLAAATQLNQAGHNVTVFERADQIGGLLRYGIPDFKLEKWTIDRRLKVMEEEGITFKTNANIGVNIPVSELEEKFNAIVLCGGSTVPRDLPLPGRSLKGIHFAMDFLSQQNKRVSNRENVLINHQGVDTKEDIFATGKNVIVIGGGDTGSDCVGTSNRHKAKSVTQIELLSKPPESRTQLNPWPEWPMTLKTSSSHDEGCERAWAILTKEFIGNDKGELTGLRLVDINWGKNGMEEVPGTDRVIPCELALLAAGFVHPQKEGMIEQLGLELDERGNVRAENYATSKSGVFTAGDMRRGQSLVVWAISEGREAARAVDEFLEGASKLPSKSKSFYQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUK2</accession>
    <name>A0A654DUK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="453"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="574" mass="65218" checksum="DC8E4E74EB81C304" modified="2020-04-22" version="1">MSRRLLEKQIARIKEKYPEEEFFDKLFEKVASSYVDFDRVQKLKDRSIRLMSQELHDLYRAQEEKQRAFISTILGKIVDGIITCNKTGHIISVNSSAEHIIGKNEGEMKQLELSEILADFKTYDEFLSHYYLNLGKNENQIEVSILGKGKKRIPCEVSVSQFEIDDVSSIVLLRDITERKKVEAIIIEEKEKAEKASRAKAEFLSTMSHEIRTPMNSIIGMTNILIQDDFDQETMNLLNTLKFSSEHLLILINDILDFNKIEAGKIDFEHIDFNLKELVENINESHKYRANEKGVKLELTIDPSSPNWVVGDPGRLSQILTNLIGNAVKFTKEGSVTTRLTPQQRKGNTIDILFEVIDTGIGIAPGKQKLIFESFSQSETYTTRQYGGTGLGLAITKKLIELQNGCLEVSSSPQMGSNFHFSLQFTLSDTPDDVVTKPVDGMYASQDDLVGLKILLVEDNPMNQFVAGKFLNKWACNVTIAENGNEAWEKIQEQEFDIILMDLQMPDKNGFETTQQIRNSDKAYKDIPIIALTATAFLEEKNRALKAGMNDFVTKPFNPKELYEKILKNMTHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW3</accession>
    <name>A0A654DUW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19375">
        <property type="entry name" value="UDG-F3-like_SMUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032579">
        <property type="entry name" value="DUF4918"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16265">
        <property type="entry name" value="DUF4918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="223" mass="25688" checksum="9C45941E54342F71" modified="2020-04-22" version="1">MTVAENILNFYQSLTPPSGLLPDVVVLNPYKDEQAMEACTLFYQKYYSDSRERIALFGINPGRFGGGLTGVPFTDPIHLEETCGIKNNLDKRPELSSRFIYEMIAAFGGPALFYQNFYLSAVSPIGFVREGKNLNYYDINGWPDIFEEYVVACIREQLELPISRKVAFSIGQGENLKYLNALNARYNFFDEIRTVPHPRWVMQYRLKRKTEFVQQYIESLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX9</accession>
    <name>A0A654DUX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="27332" checksum="82D3FC25EF44D733" modified="2020-04-22" version="1">MKVKVSYQTLQLPPPLAFAYTLEMEFHEEEIKIQYDLEFLNRDEITLEEIEEEGFSENDDYSWTGTLGKAWVEDLYDDLLEVDLEDESEDFNIYLHMEISHDGQEDSGIAVMAEDWDYRLQEVIQAIYEKAGIEDKLKLKFIHQANGERSFYELEGSFEHKTCQINQKDISWDELHQLMSDVYTIDFEGESVEKPSGDGLWIDQDAMSGYQLFDEQAGPKAAKIKSRILDILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY3</accession>
    <name>A0A654DUY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surface antigen-like variable number repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA" evidence="2">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="481" mass="55899" checksum="5E79EDAD0B737782" modified="2020-04-22" version="1">MKLYLLLLVAFWGGSMAFGQSEKGNRKQATRQDTLDSRLIQVHKIFILGNEKTKDYIITRELRVQEGEYVPAGSLDELVETSRNNVYNTNLFYSVTIEKLVLDSSTVDLLIKVEERWYIWPSPVFRLADRNFNDWWYNRNHDPSRVKYGLKLDIYNFRGRKESLRFIGLTGFEKRLIFQYSIPYIDKSQKHGLTFGGGYLNNKKLPYKTTDHFTVFTDSSTAERINREATSGYIVYTYRPSFYNYHYLMLQGYSMNISDTIAALNPNYFGDGTTSQQVLGLSYSFSQDKRNNKNYPLTGHKTLAMIEKLGLGIFQDVDIWRLTANHYHYFDMGSGFYGNVSIGGQLTTSDNVPYFNYTQFGLDNYYVRGYELDVIEGPQNFLTKNTLKKLIFSTQANLGQAMPLKKFRKIPFAFYAKMFGDAGWVNNYPGYYQSDVLTNRLLYGVGLGLDIVTLYDITFRFEYSYNAQGERNFFINFQSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV25</accession>
    <name>A0A654DV25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5371" checksum="E1A9FE5F19BF6AC8" modified="2020-04-22" version="1">MGGLTRFLGKILPVGWRFLSKPVGLDLDSPVVRWACANPPNFACLYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC2</accession>
    <name>A0A654DVC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020912">
        <property type="entry name" value="UPF0295"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11023">
        <property type="entry name" value="DUF2614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="107" mass="12373" checksum="B355332C6AF039AA" modified="2020-04-22" version="1">MEIENIWVIALMIVVIPLFFWMRVSSINKRKKGVTVRCPHCEKDQRLEKLRNYVCEKCDTPVAFFDEQGDPLKEITYYECMACQEKNFMGILTCTACGMANKAGIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVE4</accession>
    <name>A0A654DVE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="19140" checksum="670BFCC7EAB56037" modified="2020-04-22" version="1">MRLIAFSALLGSLVILSGCGVYSFTGASISPTVKTISIQTFFNNATLGPSNMSVLFTESIKDYYQQNTSLSLVDDNGDLQIDGYIADYTITPVSATASGNNDQADFASMSRITITVFASYINTQDDEFDFERKFSFFKDFDNSQDISSEEQILVEEIFDQIILDIFNASVANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP0</accession>
    <name>A0A654DVP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="49" mass="5481" checksum="FA0957BAC1BA310F" modified="2020-04-22" version="1">MGLHVFFTITSDGKTLISLYLFILYCFEKAAFVVGSGLFNQYSPAPIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW84</accession>
    <name>A0A654DW84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS family solute:Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="475" mass="51287" checksum="6D063E5562F4362C" modified="2020-04-22" version="1">MSIHWIDLLVFIVYMIAMLGVGAFFLKKNKNTEDYYVGGRSMSSWHVGLSVVATDVGGGFSIGLGGLGFTMGLSGSWMLFTGLLGAWLAAVILIPKLSALPEFKKLFTFPQIFSIFYDKKTALLAGIISAIGYAGFTSSQLLAGAKLASSTFADLSLTNALVIMGVIAVVYTVMGGLKAVIYTDTIQWALLLSGLVFIGLPLGYVSVGGYEKIREILPPEFLSLTNIRWQDMVNWGITIIPIWFVGMTLYQRIYACKSEKAAQKAWYIAGLFEWPVMALMGVLLGMFARVGAETGMFAYLGYESAQGMDAEVGLPMLLRTILPAGLMGLMMSAYFSAVLSTADSCLMASSGNLVTDIIGYKGTDQKKFLRLSQIITLGIGVFAVLLASVMQSVLELMLYSYAFMVSGLFIPVLGGLFMKKPSANAAFFSMLIGGGTTISLILIGRDLPLGLDANIYGISLSLITFVMINQFRNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWF4</accession>
    <name>A0A654DWF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized membrane protein YdzA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ydzA</name>
        <name evidence="9" type="ORF">MARINOS108_11004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="11415" checksum="B17695A79AC83731" modified="2020-04-22" version="1">MNLKTPIGRLRVLAILEGVSFLLFAITMPLKYWLQIPEPNLYVGMTHGWLFILYVLFCIQNIFIHGWGIKASVLSLGASLVPFGTFYADAKIFKPQQKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG0</accession>
    <name>A0A654DWG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016944">
        <property type="entry name" value="UCP030066"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030066">
        <property type="entry name" value="UCP030066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="13820" checksum="F49DFB09231D62ED" modified="2020-04-22" version="1">MKNLNIYYWISIGLILFFLVPGSIMNIMKSPDWVEVFTQLGYPEYLLPFLGVAKLSGCIALVLPKFNRLKEWAYAGLFFDLIGATYSGLMVGGFEPAMLIMFVAIATVLISYWLWHKKLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG3</accession>
    <name>A0A654DWG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="69" mass="7815" checksum="24744D4CC9826C0D" modified="2020-04-22" version="1">MKDDSCFFTSGIIRLWIVGEFSVFPDGNSESHGFVLPFDGAQADKAKACRLPDWSWEQAFANYRVDCHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWU4</accession>
    <name>A0A654DWU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6206" checksum="A7E6A4ED09A195AB" modified="2020-04-22" version="1">MVISDCKISDLPHQPYQKIFANCKNLISGAGANRVVSGKFSKSRKQGMVLPKVKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV6</accession>
    <name>A0A654DWV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="263" mass="31378" checksum="4C461591F4244E31" modified="2020-04-22" version="1">MIPKPYIAQWQEFAPWRQFSQVEQDLIISRALVEIFADDFLRENLAFRGGTALHKLYLTPAPRYSEDIDLVQIKPGPIKPIMERLDEVITFFEEDRRTQNRGHGIKALYRFTSEYEEIRLRLKLEINCKEHFNILDWVDFPFEVKSDWFSGQAQIRTYSLSELLGTKLRALYQRNKGRDLFDLDYARQHHELNFEEIIKCFKEYTQFSTDKRPPSQKEFLLNLEEKNNDPDFSGDMEAVLRPGIEYNEETALEWLKKDLIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY2</accession>
    <name>A0A654DWY2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="18949" checksum="EA708BE64DFD05C7" modified="2020-04-22" version="1">MKFLLTLLLISGLTAGQWEFKTVPSQSTMTILGTSSLHDWESKVGDFVVSGTMGENLINNLKVEVNVKSIKSGKSIMDDKTYDALKSEKFPTVYFTAESLALSGSKAEGLGVLTLAGVSRTISLEAQTTIKGAGTVQVNGEVSIKMSEYGIDPPTAMFGSLTTGDQVTIQYQLLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD0</accession>
    <name>A0A654DXD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Assimilatory nitrite reductase (NAD(P)H) small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13960" checksum="1D7F313BC13A45AD" modified="2020-04-22" version="1">MTEDILEYRTVLPAQVTTWYPACRVEDFPKDGGLCISYRGLQIAVFNFTRRQEWYATQNLCPHKHQMILSRGMIGSEGDEPKVACPFHKKTFSLKTGANLNGNECELATYPVKVENGTVLVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG2</accession>
    <name>A0A654DXG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="193" mass="21508" checksum="5FAD801EDE666E6D" modified="2020-04-22" version="1">MKKILVIDNYDSFTYNLVHILRELGAENRMEVHRNDKIAVDYAAGFDHILLSPGPGLPKDAGVMPEVISKYGSSKNILGVCLGHQGIGEAFGAELFNLPTVFHGVATDVELTDKKDVLFSDLPNVFKVCRYHSWAIKPDSIPDTLEVTAVDESGNVMAIKHKEFNVRGVQFHPESIMTEHGKKMMQNWLSVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG5</accession>
    <name>A0A654DXG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="350" mass="39151" checksum="B008B89164391508" modified="2020-04-22" version="1">MKKNNKEITIYDIAKELNVSPSTVSRALKDHHSIGKKTKKAVLKLAQERGYQPNTIAASLRSNKTTTIGVIISWINKPFISSMISGVEIAANKAGYNVIISQSHDNYEHEVANAQALFASRIQGLVVSLAMETTNYDHFQQFVQKNIPLVFVDRVTEELNADKVIIDNFLAGFKATEHLIQEGCKRIAHIGGAQHRNVYRERREGYLAALKQYNMEINEDYIIENPALSSEEGHRESEYLMNLPNRPDGVFCANDTSAVSVIQYARKAGIKVPQELAVIGFNNDPVTTIIDPPLSTVTHPAIEMGKLAAMQVLGYKEHKEIVRSQTIVLETELLIRESSSRKKYHPTPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK9</accession>
    <name>A0A654DXK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024791160" evidence="2">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="33116" checksum="6E350281A0FC821B" modified="2020-04-22" version="1">MEKILFLIIAIMITYASQAQHDETINGTTFKTNGNVGIGTSNPSGQWGEKLHVFSSNSNNGIKIERGDGASGSFLAYQNAVYLGSGSSHNLGFLIGGTTKVLLNTNGILGIGTTTPSTQWGEKLHVHSNNSNTGIKIGRGDGAWGSFLAYEDGVYLGSGSVHKLGFLIGGQTKLLINQTGDVGIGTTSPDAKLAVNGTIHTKEVRVDLNGWSDFVFEKDYELLTLEEVEQHINENGHLPEIPSEAEVTENGINLGEMNAKLLQKIEELTLHLIQEHKNTQELSKKIERLENELTTLKNEQKAKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY24</accession>
    <name>A0A654DY24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="19859" checksum="B5EEA3F45B9286DE" modified="2020-04-22" version="1">MHLEIVKAGQEDHQELLAFAKENFLLTYAHRNSTENIQHYIKEAFDPRSFKDELLNQNSVFYKCQLNEEMIGYYKINYAEAQTEPDYPESAEIERIYVSTDQKGRGVGRKMIQHAKAQAQAKGLDYLWLGVWEKNPEALSFYEKMGFEEIGTHVFQLGDDAQTDIIMKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY44</accession>
    <name>A0A654DY44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019238">
        <property type="entry name" value="AbiEi_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09952">
        <property type="entry name" value="AbiEi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="347" mass="41650" checksum="F9DD9C1A3B123F76" modified="2020-04-22" version="1">MIKFVHVFFLFTYREQIIFVNIMQREIVNIALENLEKETGITGKWTDRNDIDGEVDFVINDENFHYYVEVKTEVRPHQVNQLLKYQKQFNNVLLIAERIFPKVKTELRELNIPYLETNGNVFIKKDSFWLWIDTNRREETKKETGNRAFTKTGLKVLFYLLLHKDNVNHPQRLIAEETGVALGNIPLVMNGLKDTGYLLQRDRKTYIWERKEELIDRWITEYEITLKPQLLIGRFHLPTHWQELELNEFEEAWGGEPAGDILTNYLRPEQYILFTKKNRTDFIKTYKLRPDQKGELELFEMFWGMNQEKQHQTAPPLLVYADLKLKNNKRCRETAEMIWNEHIRPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY61</accession>
    <name>A0A654DY61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator, LylTr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="27466" checksum="B4C4CD0717D31B84" modified="2020-04-22" version="1">MSEKINIYIVEDEAITVATIKSYLHQVGYEVCGVADEATAAWKDIQSMEVDLAILDINLIGEKDGIWLAQKIHELGTIPFVFLTAYGDRKTVESALTFKPDGYLIKPFEEMELYTAIKIALEAFANRSTSPPPAETDNMMVNESLFIKDEHILVKLTVDEIQFVKSDGNYLELHLSGKRHLIRSKLVDFAQRLPANFIQVHQRYLVNLSKVEVIGNGYLTVVGKEIPISKTFKDNLFRSIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI7</accession>
    <name>A0A654DYI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="490" mass="56145" checksum="A0C2AA2968AFAFD8" modified="2020-04-22" version="1">MKRFEMRHLQKITLSLICAVILLGCDVEPRQPNFLFVLVDDQSAFDLKTYDPNSVLETPNIDRLAEAGMVIESARHMGSMSGAVCTPSRHMIMSGRTLWHLPPSAEFSKQTDLHPIDDFTIGAVFNRAGYKTMRTCKRGNSYPGANRQFAVVKDKTNREGTAEDGSAWHANQVLSYLQEREATREKDPFFIYFGFSHPHDPRNGTPELLDKYGAVNLDDTLAYPLFNPNLPPLQENYLMKHPFFHGHPELRDEERVSGVWKRRDTLTVRNELGREYACSENIDTQLGKVLKKLEDMGELDNTYIIYTSDHGMSIGRHGLMGKQNLYEHTWRVPFIVKGPGIKAHQRVEGNIYLSDILPTVCELAGVEIPETVQGTSFKPVLMGEQSSVRDVQYGVYCGGTKPGMRTVRKGDWKLIKYDMMDGEVRETQLFNLAENPHEYLAEHRRDDEMETNLASNPEYADKLREMEDLLLEQMIAYEDPYRLWDQEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYT7</accession>
    <name>A0A654DYT7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="20543" checksum="5D4C2CB259C44639" modified="2020-04-22" version="1">MANSRNFNLMRYLTIFIALIGLSCCSTPKQEQQQITEPLETEQPSESNEEQDTLESPTAEISISDEPLSFEILKQTSWRWEALPNCFNFLEFHTDSTGSLVYECEIDEIDQMKYLINGDTLLASFFYTPHVDNPTGELRKRTDAIYRYTGNSLIRLDRNKYMEEDLVIEYIRLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW0</accession>
    <name>A0A654DYW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_12073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="178"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="322" mass="34293" checksum="D202C722B68860A4" modified="2020-04-22" version="1">MIYFLFLIGFVLLIKGADFLVEGASSLAKRNNIPELVIGLTIVSFGTSMPELIVNLLASFDGSSELAIGNILGSNIANVLLILGVAAMIRPLTIQKSIYFTEVPISLFATVMVGFLANANLFVDVKGLTLSRYDGSILLFFFALFMTYIYVVSKSKQSIQEEAASAQTISTLPKGRSIAYIVIGSLALFLGGKWVVDGAFEIALFFGLSETFIGLTVVAVGTSLPELVTSAVAAKKGQSDMAVGNVVGSNIFNILWILGLSSVIRPLPFDVVSNSDILMVIASSTLLIVAIVIGRKASIGRVMGTIFVLTYAAYLAYLVMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ5</accession>
    <name>A0A654DYZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012640">
        <property type="entry name" value="Membr_lipoprot_lipid_attach_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08139">
        <property type="entry name" value="LPAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024983868" evidence="2">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="20365" checksum="86A601D2139C73ED" modified="2020-04-22" version="1">MKKFILILLPILALAGCQSRTYYGAQSTNLQRFDGWQEENATFLMEANDLTLLLQNLSTLAMTEANRRDTYLTAEEAYPEFQNLLLDFKIEAAARRVKLSSVLSKDNDLIYQQLRTAQKDDFDSLYQKIMLQKIAELQSISEDYTLKGHNEGLKDFSEKIINTLSPLREKIKALEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ35</accession>
    <name>A0A654DZ35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="4">4.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metC</name>
        <name evidence="4" type="ORF">MARINOS108_110099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD15938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="41560" checksum="66A292B583E42A1D" modified="2020-04-22" version="1">MKFGTKAIHAGQEPDPTTGAIMTPIYQTSTYAQASPGQHKGYEYARTQNPTRTALEANLAALENAQFGRCFSSGMGATDAILKTLEPGDEIVSTNDLYGGTYRIFTKIYERYGLKFTFVNMQDLESVKKALSPKTRLVWIETPTNPMMSIVDIRAVVNLAKSVGAKTVVDNTFASPYLQNPMDMGADMVMHSVTKYIAGHSDVVMGFVGSNDPKIDEQIGFVQNSSGAIPGPQDCFLVLRGIKTLHVRMDRHCDNGEQVARYLKDHPKVKHVYWPGFEDHANHEVAKKQMKRFGGMISFVLADDSQAAAFKVLENLKVFTLAESLGGVESLAGHPASMTHASIPREQRLEAGLTDSLIRLSVGIEDIEDLIEDLKNAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ66</accession>
    <name>A0A654DZ66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="58" mass="6823" checksum="A2EB1C2E5D45C9F5" modified="2020-04-22" version="1">MKRFEQLKELVDSLEADFSKFYDKENSAAGTRVRKGMQELKNLSQEIRIEVQDMKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ70</accession>
    <name>A0A654DZ70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="21335" checksum="F1D2104EA577DF03" modified="2020-04-22" version="1">MTLHLSAYSEAWPAHFETMKEALLQLFPEEARAIEHVGSTAVPGLIAKPVIDIFMAVSPFRKVEFYEERLQSEGYHYVPTGMTERYLLSSHTPEGVWTHNLHVLPYSPDFLLRNEILFRNYLRKNPDLIQEYNRLKKHLSSMPLASLEDYTRAKTGFIQQVVDKARKACGLPRQNVWTMEIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE7</accession>
    <name>A0A654DZE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024840567" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="26468" checksum="579C1F41003A4DF8" modified="2020-04-22" version="1">MKQSFYILLIWVTLAYACDPCADCGEPLRYDPTVKMIFINQDSADVLNDSIQFNKDSIATNTALRKVNTDSMKVLQDSLIIVDTLVAAGKEEYIEVQDLFNKTIDSLSIVSDSLSSYSKQLTAINTELTKILTVINKGTVQLQHTSILENGAELSYEDSTTSFRLPLLLASNQTSYRITIDGIDYSIAFTYETFESIDKARVAKVSAGNLEVLSHSFDSLTLNCPSDCISDDATVTVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI8</accession>
    <name>A0A654DZI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024903888" evidence="1">
        <location>
            <begin position="20"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="608" mass="69268" checksum="BF4006E6E7B68A19" modified="2020-04-22" version="1">MKIILRNTPLLLLIVTMWACSPQAEKIYTSEEIAAESEKALTFFDQAFDEMVDRYPVYQSYLGIKKDYGKWDDISDEMEQKELEFTKANLQYLLDSINYDALDYQSKLSYDLFKMDAENSIADFKYRQYNYPVHQMRGTHTMVASMLINIHSIADSSDAAAYVARLNGVDQLFDQLIVNLKTREDLGIIPPKFVYPRVLEACANIISGTPIDKSAEQNAIYADFSGKVESIELDAEAKKVLLAGAEDALINTVKPAYEKLIAFLQEQETRATSDDGAWKFPNGEAFYNNALQRTTTTELTSAEIHEIGLKEVARIHGEMREIMKQVNFEGELQDFFEFLKTDAQFYYPDTDEGKVAYIDSATTIIDNMRQQLDNLFLTKPKADITVKRVEAFREESAGKAFYQAPAPDGSRPGTYYANLSSTKNMPKYEMEALAYHEGIPGHHMDRSISQELTGIPKFRKYGGYTAYVEGWGLYCEYIPKEMGMYANPYSDYGRLAMELWRACRLVVDTGIHSKKWTRDEGIAYYQTNTSGSERECVRMVERHIVMPSQATAYKIGMLKILELREKAQTEMGDAFDLREFHDVVLTSGAVPLNVLEDLVERYIASKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZK3</accession>
    <name>A0A654DZK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="145"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="809" mass="90560" checksum="7E0A56F2E8BAB61B" modified="2020-04-22" version="1">MNTLTIRNQTVKILIGIALALFLVSNSFGQTQVIKGKIIDAQAEYELIGATILVLGSEPMLGTITDVDGTFRLENVPVGRQTLAVQYVGYKNQTIPNVLVTAGKEVILQIKLEESVENLEAVVVTASASKDLPINEMAKVSARTFSLEETTRFSGGRNDVARLATSFAGVSAPNDSRNDIVVRGNSPTGLQWRIEGIPVPTTNHFATLGVTGGPVNALNTNILRTSDFLTGAFPAEYGNANAAVFDVNFRNGNADKFEFTGQMSAYSGMELMAEGSINREKNSSFVATYRYGIASLAATGTSAVPYYQDFSFKVNLGETKIGKFEVFGLGGLSSIDFKGDEVKEGDLFADPAVDAYIDNTLGVIGMSHLMRPNKTTYIKTTVGASTTQNNYYQDNLLKDNGGETVGKFRATNVETADSRYTLSSVVNKKFNARWNLRAGYLGELYHADFLYNDRDNRAEIPDENNDEIPDYFIPVRNVSEYYLLSRVFGQAEYKLTDNLSTTFGVSTQYLGLSERFSVEPRAALSYQFTPIQRISLAYGLHSQMAPSPILFLQEETSPGVFERTNKNLDFIKSHHFVAGYDRNLGKDWRFKSEIYYQHLYNIPVQSTPSSYAIINEGADFVFDERGSLVNEGTGRNYGLELTLEKFFSNDYYLLMTTSLFDSKYSGSDGIERSTSFNNQFVYNVLFGKEWKFGPAQRNAWTFDTKFTTSGGKPYTPVDLEATRANAGREVRMDEIAYSERYANYFRWDVKFGVRMNSSRRNISHQFFVDLQNVTNRKNEFVRRYNEVTDEVNSIKQIGFFPDVMYRIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZS2</accession>
    <name>A0A654DZS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024880891" evidence="2">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="15054" checksum="904B73B06E3E2D99" modified="2020-04-22" version="1">MKLLKTSLLLSALVLCFSCQTTESSSEETLSKQALEKNLEETKDDLEKKIAELQEGAGELAEDARFQTYKAVEKLQAERIKVRRMIKKVKNSSEKDLKRVSKEAKGVYEDAGKQLDNIRNEFNDWLEKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ0</accession>
    <name>A0A654DZZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug DMT transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009834">
        <property type="entry name" value="Ureide_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07168">
        <property type="entry name" value="Ureide_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="35622" checksum="E66ABD1E3EC15641" modified="2020-04-22" version="1">MYIISSYSIAVFFTIITMLCWGSWGNTQKLAAKTWRFELFYWDYVIGILILSVLFGLTLGSTGDQGRGFVEDLGQLSSSTIWSAIIGGVIFNASNILLSASISIAGMAVAFPLGVGIALVLGVIVNYVSAPKGDPVMLFIGVALIMIAIILNGIASGKMTKDGKKSSSKGIWLALIAGVLMSFFYRFVAAAMDVNSFEAPLAGLATPYTAFFIFAIGIFISNFLFNTIIMKRPFVGQPVTYKEYFKGGFSTHLVGVIGGLIWGLGMILSILSAGKAGTAISYGLGQGATMVAALWGVFIWKEFKGGGRSVNMLLFLMFLLFISGLVLIILSGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ4</accession>
    <name>A0A654DZZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4201" checksum="84EC29C66D63FCB8" modified="2020-04-22" version="1">MSFAMVVVTKKKMSKRNAMSAIDPELTSGSGRFLPLGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E011</accession>
    <name>A0A654E011_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="13574" checksum="066F0BD7328E2987" modified="2020-04-22" version="1">MKPLLYILVLSLLCSCEQTPSQNAANVSQINGLYVFIESQPQSSYDFLGEVANDFGDQMKEATDKNKKFGERLLGALSTTVENVDFGSKLEMMIEKAKKEYPTANGIIIEGKMNKIKAIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E024</accession>
    <name>A0A654E024_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="413" mass="47149" checksum="0D678DEC734FDE4F" modified="2020-04-22" version="1">MEKTSRLHLFEGYGVELEYMITDQSSLDVRPIADVLLRNAEGEVEGEMDHGLTAWSNELVSHVIELKSNGPTGDLVALRDKFVLDVRAINRQLVTNGAMLMPSAAHPWMNPAKETKLWEHESQEIYQAYDRIFSCRGHGWSNLQSTHINLPFYDDEEFARLHTAIRFMMPMIPALTAASPVLDRKFTGYMDKRLYYYEKNQSKIPVLTGKVIPEKLFSKYAYQKHVYDRIAAAIKPFDTDHILKPVWLNSRGAMARFDRGAIEIRIIDIQECVSADLAVVALVTGLVKLLVREKLVRFDVQETFETEDLYDVFKSCVKSGSAALIQDPTYLSAWGYDQPVTGRQFWADAIQKVSQALPEYLMPWLETLNQLNAQGTLAERIMTALNGDFSEEKLKETYSKLAQCLHQDQLFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E050</accession>
    <name>A0A654E050_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="465" mass="52671" checksum="173CA31262F71691" modified="2020-04-22" version="1">MKSPLLIVLTLIVVVSCHQNDNDTLLSGQLIDAYTNEPIANARVFVLENGPETTTGANGSFQFSNDEVKLLEDVSDGSGDYAIAVSHSDYRPRELNVRRGKKTQVEMAPLAIPTYFYYPPVQLNDGIATGTLKDANMDRQLVQNLMEKVQGDGYKEIHSVLVYHNDMLVLEEYLFGNNDTIQFENDIAVDRSPAPIQWSRKDKHYVASVNKTFTSTLVGMALNQYGHSVEDKISDFLPQYAVYFEDPNKAALNFEDCLTMTAGFQWDEWGDTDLARLWKSDDFGDFVLSRSNAGAGSEWRYNSALPNLMLKAVDEMVDGGVREWADANFYQKLGIRDYKWQSQPDGYPEGSARMFIRPRDMLKIGITYLNNGRWNDEQVIPASWVSECFQVKEQTTSGDYSYHFWIRNLADTEYLSADGDGGNYINVFPSLDMVVVITQGLYLKWPLYVTQSDDMMKNFIIPAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E089</accession>
    <name>A0A654E089_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl-diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="36665" checksum="A5A686905DD61B63" modified="2020-04-22" version="1">MPIQLKDIQEPVAAEMSEFEQKFRKSMRSNVMLLDKITSYIVRRKGKQMRPLFVFLSAGAAGGINESTYRGASLIELLHTATLVHDDVVDDSHYRRGFFSVNALWKNKIAVLVGDFLLSRGLLLSLNNDDFDLLKIVSNAVKEMSEGELLQMEKARKLDITEEVYYDIIRQKTASLITACCRVGASSAGADPEVIERMTQFGENVGMAFQIKDDLFDYGTFEIGKPTGIDIKEKKMTLPLIYALNQVGRSEKKRIRRMIKRSADEPKLVNEVIDFVKASGGIKYATDVMTDYHQKANKLLAELPESTYRTSLEQLVQFTIDRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E092</accession>
    <name>A0A654E092_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">purB</name>
        <name evidence="14" type="ORF">MARINOS108_120376</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="12">
        <location>
            <begin position="48"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="13">
        <location>
            <begin position="332"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD16793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="449" mass="50708" checksum="B9F7F0E1ED1EFBEB" modified="2020-04-22" version="1">MTMELNDLTAISPIDGRYRNKVASLAPYFSEYALIYYRVKVEILYFISLCEIPLPQLTKVDHGKFADLKAIYENFSEADALKIKDIEKVTNHDVKAVEYFIKEKFDLLGLGSFKEFIHFGLTSQDINNTSIPLSTKEALKDVFIPYLKETIALIDKVAQEWKDIPMLAKTHGQPASPTRLGKEIAVFVSRLNEQLSGLEQVPYAAKFGGATGNFNAHYVAYPDNDWHTFGNDFVGQKLGLKRSYPTTQIEHYDYFAALFDAIKRVNTILLDFSKDVWQYVAMNYFKQRINPNEVGSSAMPHKVNPIDFENAEGNLGIANAMFEHLSSKLPVSRLQRDLTDSTVLRNIGVPVAHTLLALSSLKKGLGKLEVNKEAIHKDLDDNWAVAAEAIQTILRREAFPNPYEALKALTRTGDKITKDTLHAFITQLEVSDEIKAELMQITPFNYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E094</accession>
    <name>A0A654E094_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="33365" checksum="0657C9B95788489B" modified="2020-04-22" version="1">MSGSENLFLAAVLFQSTGTNHLIREIRPISGGDINEALKVTTDQHTYFVKWNTYSENLFERELHGLSLLRECGCVGVPQAYKHGQIGDRRYLVLEYLHPAPQKDHFWESFGQAIARLHQHTADYYGLDHDNHIGRLPQKNQPTSDWIDFFIENRLEVQIRLAHEKGLITTDLLESFEKLYGQLESLIPTEPASLLHGDLWGGNFMSGPGGEPYIYDPAVYYGHREMDLAFTRLFGGFEPAFYEAYDQQYPLEPGFEERADLYNLYPMLVHVNLFGPSYLTGIRRTLKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0H4</accession>
    <name>A0A654E0H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02231">
        <property type="entry name" value="TIGR02231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024900616" evidence="1">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4140" evidence="3">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="211"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="526" mass="59367" checksum="F06E087F5B84D451" modified="2020-04-22" version="1">MKFIIVCFLSFGLWSASAKGIDSKVESVTIFLNQAQVSRSSNIAIGPETKQLVFTGLSSMLDPNSVQVKGQGDFIIMGTTFRQNYLTEENLPDAVKSLKDKIELLEGKIANVDNQQWALKSEEEMLKANQVIKGANQNLGVNELKAMTEYYRIRIQAIKDKGYELQLERRELDKALKKVKNQLEEQHAREQMVSGEVVVDINTSKTQMVHLDLSYVVSGAYWNPTYDLRATSSAQKIDLLYKANVYQNSGENWENVKLTLSTSNPSIGGWLPTVRPWYLDFFSAAPYQNKLAMPAARSEAFEPVPMEEEVLMESVADYTQMSEGLTSVNYEIALPVTVLSGGKEVTVAIREERVEAEFLYQSTPKLSERVYLVAKTKNWQRLDLLPGEMSVFYEGGFVNKTYLNPEGELEGLNISLGVDQGVQISRKPVRDLTNDQLIGNKRRISYQYEIKVKNNRSKSIDIEVFDQLPLSKNTDIEIGEIALGGAQRNEKTGLLTWSFTLEPTMEKSMKFGYEVKYPKDKRVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J6</accession>
    <name>A0A654E0J6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsH</name>
        <name evidence="7" type="ORF">MARINOS108_120483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD17104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="14806" checksum="6496531E0D9FF02B" modified="2020-04-22" version="1">MVTDPIADYLTRIRNAIKANHRILVIPASNLKKEVTKVLHEKGFIQNYKFEDDDKQGIIKIALKYNPQTKQSAITSLERISKPGLRKYADAENLPRVLNGLGIAILSTSKGVLSDKEARKEHVGGEVLCYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V8</accession>
    <name>A0A654E0V8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_140040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="401"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="460" mass="50009" checksum="29315814742C2B26" modified="2020-04-22" version="1">MSLIKSIAGLRGTVGGKVGETLTPIDVAKFTAGFGMWIKETHDQPKVVIGRDARPSGVIFTAIVENTLRAQGIDVVDLGLSTTPTVEMAVVNEKAQGGIILTASHNPSGWNALKLLNENGEFITAADGQKVLAWADSPDLLFMDPKKFGTVETKDDYIDWHIEQILKLDLVNVEAIREKGFKVVVDGVNSTGGIAVPKLLRKLGVEVTELFCEPNGIFPHNPEPLPENITQICNEITSGDFDLGFVVDPDVDRLVMVCEDGVPFGEEYTLVSIADYVLGKKSGNTVSNLSSTRALQDVTEKHGNTYKAAAVGEVNVVTAMKETNAVIGGEGNGGVILPELHYGRDALVGIALFLSHLAEFGKSTSMLRATYPSYHISKNKIELDANLDLDSVLENLQLKYAKNKFSTIDGLKIEFDNEWVHLRKSNTEPIIRIYAESDSQSTADHLAQKLMMDIKELISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E101</accession>
    <name>A0A654E101_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4930" checksum="E92314895771E475" modified="2020-04-22" version="1">MDSAKYPPPQMALLPYKKIYYLVAKMPILSFSVHLINHYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E123</accession>
    <name>A0A654E123_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="36435" checksum="2DCA7B25F9A1AEBE" modified="2020-04-22" version="1">MREKQSKSVNNQLMSIRLADIKQFESLDLLARQLVEGFITGLHKSPYHGFSVEFAEHKLYNFGESTRHVDWKVYARTDRLYTKQFEEETNLRAQILLDVSNSMYYPKPGLDKIRFSVLCAASLAHLLTSQRDAVGLTTFSDEILYQSALKSTKTHLNQLLTQLSDLLSTPGKAATNVANVLHQIADKIHKRSLVILFSDMFQKSNDLDEIFGALQHLKHNKHEVLIFHVSDHKTELEFEFEDRPHRFIDLETNETIKLNPREIKDHYKQHMSQLYQDLKIRCGSYKIDLVEADISEPFEKILGAYLIKRKRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E133</accession>
    <name>A0A654E133_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008670">
        <property type="entry name" value="CoA_reduct_LuxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05893">
        <property type="entry name" value="LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="38053" checksum="E8E7D57B67E57B44" modified="2020-04-22" version="1">MTLSERIEAFSILGDKIRAISNDSLEEYARRAQLHNQWFTKENVSRAFEGIAFMLKKEKLQQWLEPYEPLSPEVPKITGIIMAGNIPMVGFHDLLSVLVTGHFATIKTSSQDTYLVKLLIDWLLEIEPRFKKNLEIRERLTAIDALIATGSDNTARYFEYYFRNHPRVIRKNRTSVAILDGSETETELKALGKDIFWYFGLGCRNVSKVFVPTNYDPRGFFEANEALNYLGDHNKYRNNYDYHKSILLVNGVKHLDNGFLLWQPSEELVSPISILYAEEYENLETLNTKLAANADKLQCIVGKGHTPFGQAQTPEVWDYADGVDTVAFLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C1</accession>
    <name>A0A654E1C1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase-like lactoylglutathione lyase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15840" checksum="A89C4A4BAC078C07" modified="2020-04-22" version="1">MNNQIKFHIALNVSEIGATVDFYKGLFNAEPVKLKDDYAKFELDEPGLVISFIQAPDKVSSHFGHLGLRVANEAQLAKRKEEVEKKLQIALEETNTNCCYAQQDKFWVNDPDGYEWEVYHFKKDVDKNDKRPQAVACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C4</accession>
    <name>A0A654E1C4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gatC</name>
        <name evidence="2" type="ORF">MARINOS108_20042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="95" mass="11097" checksum="6D88966FFF2460C1" modified="2020-04-22" version="1">MKIDHQTLEKIAHLARLEIHPDKADGYIKDMEEILTWVEKLNELDTEGVEPLTNMSFEENALREDVKKAPLDHERALKNAPKKDDDYFRVPKVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M5</accession>
    <name>A0A654E1M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rpoC</name>
        <name evidence="10" type="ORF">MARINOS108_120505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="249"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="476"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="478"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="EMBL" id="VXD17133.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1434" mass="160136" checksum="CB7B1E965548AE5C" modified="2020-04-22" version="1">MAFRKNKKLSNDFSKVTISLASPESILESSHGEVTQPETINYRTYKPEMGGLFCERIFGPVKDWECHCGKYKRIRYKGIICDRCGVEVTEKKVRRERMGHIELVVPVAHIWYFRSLPNKIGYLLGLPTKKLDQIIYYERYVVIQSGIKEEDGINEMDFLTEEEYLDILDKLPRENQLLDDDDPQKFIAKMGAEALEMLLSRIELDELSYQLRHQAATDTSQQRKAEALKRLRVVEAFRDAKTRIENKPEWMIIKMVPVIPPELRPLVPLDGGRFATSDLNDLYRRVIIRNNRLKRLIDIKAPEVILRNEKRMLQEAVDSLFDNSRKVNAVRSDGNRALKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKMHECGLPKDMAAELFKPFVIRKLIERGIVKTVKSAKKIVDRKDPVVWDILENVLKGHPVLLNRAPTLHRLGIQAFQPKLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLGHEAVLEASLLMLSSHNILNPANGAPIAVPSQDMVLGLYYITKGRRSTPEKPVIGEGLSFYSAEEVIIAINEGKVSQHAYVKVRTKVRNENGELETKVIETVAGRVLFNLHVPEEVGFVDELLTKKKLQKIISTVFKITGMAKTAHFLDDIKELGFQTAYKGGLSMGLDNIQIPAEKEALVAQAKEEVEAVWNNYLMGLITDNERYNQVIDIWTRTNTLLTNTLMQQLEEDDQGFNSIYMMMHSGARGSREQIRQLGGMRGLMAKPQKNLQGSVGEIIENPILSNFKEGLDVIEYFISTHGARKGLADTALKTADAGYLTRRLVDVAQDMVVNEEDCGTLRGLSVQALKDNEEIVESLFERILGRVSVHDIYDPITEELIVESGAEITEEVAVKIDETSIEEVEIRSVLTCETKQGVCAKCYGRNLASGRMANMGESVGVIAAQSIGEPGTQLTLRTFHVGGTASNIAVDANIKAKFDGFIEYDELRTVDSEDEEGNKVKKVMGRSGEIKILDNKKERVLITNHVPYGAILKVSDGDKIAKGDEICNWDPYNAVIMAEFDGKAEFDSIIEGVTYKEESDEQTGHREKVIIDTKDKTKNPAVVVAGKDESKGYNIPVGAHLAVDIGDKIKAGQVLAKIPRKTGKSRDITGGLPRVTELFEARNPSNPAVVSEIDGVVTYGGIKRGNREIFIESKDGVKKRYLVPLSKHILVQDNDFIRAGDALSDGAITPADILSISGPTAVQEYLVNEIQEVYRLQGVKINDKHIEVIVRQMMQKVIIIDAGDTSFLTNQSVDRFAFMEENDNILDKKVVMDPGDSETLKAGMIITSRKLRDENSNLKRRDMKIVEVRNAEAAVSKPILQGITQASLGTESFISAASFQETTKVLSEASIRGKADYLSGLKENVIVGHLIPAGTGNRNFLNHIVTSNEDYENLVAAKEQFANSKELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V5</accession>
    <name>A0A654E1V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="14992" checksum="4A63C0CC5D0152A4" modified="2020-04-22" version="1">MDFTQIKETCLYVRDLDQTRHFYEGILGLKVISHQKQRHVFFRLGSSVLLCFNPEATRNETMLPPHFADGKQHIAFEVAPKDYEGVKKSIIDLGVTITHEQEWRPSVRSFYFEDPDGHVLEIVPAGMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Y7</accession>
    <name>A0A654E1Y7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="21657" checksum="C103EECA9C3ED17B" modified="2020-04-22" version="1">MGEPTTKIQRLYFVALIPPEPIKSEVWQMKEEVKSKYGSKAALKSPAHITLHMPFTFRVDREDQIIHCLQEAVTGTPSIRIKHDGFGCFEPRVIYVNVEKTAPLENLKKNVVKQMRLNLKLQNADYKNLPFHPHMTIAFRDLKKATFQEAWPEYRQRSYEANWECGTVCLLKHTGKDWAVLEEVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E280</accession>
    <name>A0A654E280_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Murein DD-endopeptidase MepM/ murein hydrolase activator NlpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045834">
        <property type="entry name" value="Csd3_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19425">
        <property type="entry name" value="Csd3_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Csd3_N2" evidence="7">
        <location>
            <begin position="154"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="6">
        <location>
            <begin position="286"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="432" mass="49116" checksum="A24462DF05E1921E" modified="2020-04-22" version="1">MSKKIVFGIGVVLAVMLVYFYGSTNEGLEIETISIEEPDSLFQEILPEPTLLYGIAIDSFDVFEGKVKWSQNISEILSSFNISREDIYALANASKGVFDVRKLKAGYPFTIIHERDELKTARQFIFEPDPTQYVIFNLSDSIYVQSVAKPVVREERVLTAKIESSVYEAVLAEGASPLLVNKLVDIFAWQVDFFRIQKGDEFRVIYDQRSVDGEVVSVDRILGAYFKHFDKEYFAVYYNQEGQEDYFDEDGNSLRKTFLRAPLNYSRISSRYSPRRYHPVQKRYKAHLGTDYAAPVGTEIRSVGDGVILEAKYGQYNGNYVKVKHNSNYTTQYLHMSKIAKGIRPGVTVKQGQTIGYVGSTGLANGPHLCFRFWKNGIQVDALKVDLPPSEPIDPKKLKDFLHVKNVMINKLMKIKEDSAKPMLAQIPLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M1</accession>
    <name>A0A654E2M1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="92" mass="10886" checksum="C77A34006DCBAC8E" modified="2020-04-22" version="1">MMTRSNTKSKVMITSRTMSIVCSFHMTQNYAEQANKAEKWVLEITHLGVFEVILLASTFVKAIRILQLMRQIFQSQFFKRLQSNFHYYETIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M2</accession>
    <name>A0A654E2M2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="37"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="223"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="335"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="416"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="631"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="8">
        <location>
            <begin position="700"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="820" mass="91883" checksum="52AD8DCA70E266AA" modified="2020-04-22" version="1">MTLMTKGCTKIYFFIFLLTISSELLAQRSSRERINIDTDWRFALGHAADPAQDFNFKVANIFSKTGKAEDTPISPKFNDSTWRQLDLPHDWAVELPFENVDNFDLMAHGYRPVGGLFPENSVGWYRRNLELTKADSGRRLAVTFDGVFRDAMVWINGFYLGNNESGYMGVTYDISDYVNFDGNNTLVVRVDATQAEGWFYEGAGIYRHVWLQKYDNLHIAEGGQFVYAEVKGNIAKIFIETTVENQTLANASGQVSAFITDRAGKKVGSTKSAEVTLALNGQATVKQEIVLTDPRLWSLEDPYLYRVTSQVSNGSTVLDHLTTRFGVRTILIDDKKGLSINGKFIKVQGVNCHQDHAGVGSALPDYLQYYRIQLLKEMGVNAYRASHNPPTPELLEACDSLGMLVLDETRLLNSSPEHMDQFERLIKRDRNYPSVFLWCIGNEEGYVQTTSVGKRLALTMLAKQRELDPTRTSTYAADLANVFKGINEVIPVRGFNYREKGMVPYHNDHPTQPVIGTEMGSTVTTRGIYEVDSVKGYVPDQDITHPWWASLAEDWWPIAADNDWLLGGFVWTGFDYRGEPTPFQWPNINSHFGIMDVCGFPKNIYYYYQSWWTDKDVLHISPHWNWAGKEGEIIDVWVNSNADEVELFLNGKTLGKKVMPRNSHLQWQVAYEPGSLKAIATKNGRTYETVMETTGEAHQIVLTPDRNIVTADGKDATVVNVTVLDNKGREVPTANHLVAFSLEGDASIIGVGNGDPSSHEPDKMGVGDYRRSLFNGKCQMILQAGNDPGKVMVNATSAGLKSATVSIQLVKTNNNLLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T9</accession>
    <name>A0A654E2T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase RsbW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="14990" checksum="79DFD7041B20FB50" modified="2020-04-22" version="1">MNSIQIQIPSLSENIRIVESFIDNAKEKFSLNDDIYGNIMIAVTESVNNAIVHGNRKDSRKNVTLQLKVDDNILNFTITDEGEGFNFNQLPDPTSPENLDKPGGRGIFLMKHLCDEVSFQDEGRAVILTFYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E319</accession>
    <name>A0A654E319_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="71"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="31895" checksum="7F631439AA3F94D6" modified="2020-04-22" version="1">MKIYFLPEFYSSILPKTRSISLFALLLGSIVACDTTKKQTETPAEVTEYKPVSYDFEIQTVQKKSANCAPEACSEVSISYPVFAAGHDTHASINSLLTEEINRTLSDYIMEAEGTEDTDELCKMFIASYQDFKENFPESITPWYIRLEVAVGKTDRNFISLVINHASYTGGVHPNSSVSYLNIAADGEKIEELRYFVNSTSKLQDLAEKEFRKQYNIAPEEQLSDKGFLFDNDQFSLSEDFGVSKSGIVFYYNADEISSNAQSPIILTIPFKDLTGLYKHKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E324</accession>
    <name>A0A654E324_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal protein S6 modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rimK</name>
        <name evidence="10" type="ORF">MARINOS108_20311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041107">
        <property type="entry name" value="Rimk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18030">
        <property type="entry name" value="Rimk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="104"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="32996" checksum="52D3B47956418907" modified="2020-04-22" version="1">MKLAILSRKSDLYSTRRLKEAGEERGHEVHVIDHLQCDIMIEQNALAMYYQGQKLTDYDAVIPRIGASVTFYGTAVLRQFEMMDVFSANRSIAITRSRDKLRSLQMLAAAGLDLPKTAFTNYSKEEKQIIQNLGGAPLIVKLLEGTQGLGVVLAETIKAAKSVIEAFHGLKARIIVQEFIKEAKASDIRAFIVDGEVVGAMKRTGKEGEFRSNLHRGGSAELIRLKRSEKAAAIKAAAAMGLHIAGVDMLQSDRGPLILEVNSSPGLEGIETATEKDIAGKIIEFVERNYQNKRGRKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E348</accession>
    <name>A0A654E348_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4616" checksum="8701E3452BFFFBD4" modified="2020-04-22" version="1">MRSVDKVFGLNMDFSFLFTGTKIKFDRSKMIETSIKRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E363</accession>
    <name>A0A654E363_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4791" checksum="C82221E5BF8860B5" modified="2020-04-22" version="1">MSSLFESTIVSKQYNQVSIFEKLNGLNPCFTLVWLIPPDKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M0</accession>
    <name>A0A654E3M0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ORF">MARINOS108_20663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="111"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="428" mass="46457" checksum="2D7F1F476FF37555" modified="2020-04-22" version="1">MNILVIGSGGREHAMVWKIRQSAKCDELFVAPGNGGTHDLATNLYISVEDHDGIKAAILEKHIDLVVIGPEVPLVNGLVDDLKNDPACKDLLIVGPGRNGAILEGSKEFAKDFMKKYGVPTAAAEVFDQSNIQEGYQFLEKLKPPYVLKADGLAAGKGVLITESIDEAKQNLDDLIINKKFGDASAKVLVEEFLPGIEVSVFVLTDGKDYLILPEAKDYKRIGEKDSGPNTGGMGAISPVIFADKDFMKRVEDEVVKPTIEGIRKEQMDYTGFVFIGLMNSGGVPKVIEYNVRMGDPETEVVLPRIKSDFVSLLEAAARGTLASQKLEVEPFTAATVMLVAGGYPDAYEKGKEISFTDSMKSVITFHAGTRKVQDKLVTNGGRVMALTGLGKNMGEALSHCYKAAEHVKWEGINFRSDIGFDLQELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V0</accession>
    <name>A0A654E3V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="205" mass="23446" checksum="4A551DDA3688701F" modified="2020-04-22" version="1">MRKKWSLFLAGIAWVAVLTQYFLMVENRVASVGETTIRFFSFFTILTNSLVAIYFTWWILLHKKENPSMLNKPGTLTALTVYITIVGLVYQILLRPIWEPTGIQLVVDELLHSVIPVAVIVCWYLFEDKSLVSYRQIPQWLIYPLIYLVYILIRGNGSGFYPYPFVDVGSLGLSKVLINAMGLMVLFVGISALYIKVGKSVRRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E437</accession>
    <name>A0A654E437_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminoglutamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="388" mass="44716" checksum="E0D2570894D2066D" modified="2020-04-22" version="1">MDLKLFFDPISREIDLSKLPTSALAHSIYINQEKMPEIDDKDIAIIGLQESRGAEEGNQDGISRSATEIRKSLYQLKKGSGNFRVVDLGNFRNGPELEDTYQRLQEVCAHLMEQNILPLIIGGSHDLDIGQYMAYENQDKIITMLNIDNKLDLTDPKTGIPSQSHVHRIFKHDPNFLFNYYQLGHQSYLVEEKETELLEKLYFEVVRLGMVKENIKELEPIVRDADMVSFDISAIQAHYCPGATDAKVYGLTGEEACQICWYAGLNDKLSSIGFYEYDVARDTEDRKTAFVLATMIWYFIEGFYNRKGDKNFRSNDYLVYEVALGGEPSTIRFYKSKISEKWWMEVPHPEETSGFLRSRMVPCSYSDYQMAQSGEVPHRWITTYSKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E463</accession>
    <name>A0A654E463_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_50060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="5">
        <location>
            <begin position="71"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="43754" checksum="1D28C81FC05C43CE" modified="2020-04-22" version="1">MRKSKIYTHDYPMNTQMKIIKAIVLLILSITLIHCSSEEMPKPSFGGPSDGDGTPSKQYLKEFAAFPVGNIVSASKLASSSEDNLKFKEILLNDYNSITAENDMKMANIFRGPDNYDWSDGDAIVAYAKANGLRVHGHALVWHSSIPGWLTNFAGTDEEFSKLIENYIKQTVAHFAEEKDSLGNSVVASWDVLNEYFDGTSVRSSLFSQRMGADFHKKLFQWAREANSDVKLFYNDYNVIGISSKRGAILSMVSDFQSNNIPIDGIGAQVHINYQWPTITDIQNGFQEIANTGLLIHSSELDITVNPNDDISELTAERAISQSVQFQRLAFYYGEIVPKNQQFGITVWGFRDQDSWIYEGGTDWPLLYDNNFEPKPAYDGFRNGLDGQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E487</accession>
    <name>A0A654E487_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein RprY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rprY</name>
        <name evidence="5" type="ORF">MARINOS108_20404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="26387" checksum="79D3FC037F88AFF6" modified="2020-04-22" version="1">MREPRILLAEDDPNLSFVIEDHLITEGFTVVAAGNGQEALRHFRNQAVDLCLIDVMMPKMDGFSLASEIRKVNDLVPILFLTARSMEQDRLKGFEIGGDDYITKPFSIAELTQRIRVFLRRSVTTSGVSEKKGALGTLQFDELNLLVIGPQSTAQLTQMEADLLKLLLQHRNQLVKRETILVEIWGENDYFKGRSLDVFISRLRKYLKEDPDLEIRNHHGVGFSLVDRNFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E493</accession>
    <name>A0A654E493_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ORF">MARINOS108_50090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD20666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="29565" checksum="A72EF72D6CC59D5E" modified="2020-04-22" version="1">MSVLVNKNSKIIVQGFTGTEGTFHATQMIEYGTNVVGGVTPGKGGQSHLDKPVFNTVKDAVDATGADVSIIFVPPAFAADAIMEAADAGIKVIITITEGIPVKDMMKAKPYAIARGAKLVGPNCPGVITPGEAKVGIMPGFVFKKGNIGIVSKSGTLTYEAADQVVKAGLGITTAIGIGGDPIIGTSTKDAVQLLMEDPETEGIVMIGEIGGNYEAEAAKWIKENGNKKPVVGFIAGQTAPPGRRMGHAGAIIGGADDTAAAKMKIMAANGIHVVNSPADIGEVMKKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N1</accession>
    <name>A0A654E4N1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbF</name>
        <name evidence="2" type="ORF">MARINOS108_20564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.33" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="29021" checksum="5212D60F066367D8" modified="2020-04-22" version="1">MKVVILAGGFGTRLSEETVLKPKPMVEIGGKPILWHVMKTYSQHGFNDFIICLGYKGYVIKEYFANYFLHMSDVTFDMVSNGVEYHKSEAEPWKVSLIDTGSDSMTGGRIRRVKDYLNNEPFMLTYGDGVGNVNIQELMSFHRTNKKLLTVTAVQPSGRFGSLNIDKQDSVTSFLEKPKGDGNWINGGFFVCESEVIDFIDGDQSIWERTPMERIAASNEMVAYKHTGFWKPMDTLRDKMELEQLWESGEAPWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R9</accession>
    <name>A0A654E4R9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraR_C" evidence="1">
        <location>
            <begin position="112"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="171" mass="19533" checksum="8A04D6DBF4AA9C27" modified="2020-04-22" version="1">MLPGGIMDEGHTLEESVNNVLFNLTGIHDVHQEQVKAYSSVDRHPVKRVLTVCFYALIKPENHPVIAKNYVSDVQWYSLSKLPKLGFDHDQLAVDALHKLRGSLDQNLIFGELLPDKFTLKELQDLYESILDETLDRRNFRKKILQSGLVIPTNEKKIGVKGGPELYRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T8</accession>
    <name>A0A654E4T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase family 32 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024882281" evidence="5">
        <location>
            <begin position="20"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="83"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="7">
        <location>
            <begin position="416"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="543" mass="60942" checksum="231BF074463E6D9B" modified="2020-04-22" version="1">MRYKTLKMMSLALMAVVSGCDKLHITKVGGPESESETVTSASLNCTAQAEEEDYQIFPMTSDGYRIGDVMPYFEPGTGEIFVYYLKDIWDDPSNERHPWYGFTTTNFYEYDETCTDALLASSDQGCDQDFAVGTGSVIKKGGKYYAFYTGHNPNYPSSCVSKKEGVMLATSNWPNQQFTKKANFSTIYPPSGLGFDEQDNFRDPFVYEDTQNNEYVMLISARKDVNGTWKGVLAKYTSGNLLNWTYDGVFYDGGADNYFMMECAEVFKINSTYYLLFSDIDTKYVYYRKSSSANGPWSKPTGIERFEGKGIYAAKSVSDGYDRYLMGWTHVNIGHTDGGAPGWGGNLVVHKIYQKANGDLAVTIPHTVENHLETTAYTIVKNSQWGDVTNTQVGLHSYRLYSPADYDMANVIFDPVMAERYEISATVNYVSSARDFGFMVGACDGWNDLFSLRFVPQENRFSFDKTNRSNLDTSTVPDNDVPFAMSPGVDYSVRIVIENSMVVVYINDEVALSSRIYRAPGTNWGIFADHSDVTFTNIEVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V7</accession>
    <name>A0A654E4V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="PTHR13572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024873950" evidence="5">
        <location>
            <begin position="24"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="47052" checksum="94A0965E168B424D" modified="2020-04-22" version="1">MNGMKMSTSVMWLCVMLCAGLFGCDTSGGEEEIKADVYEPVKVSKTNATKLYMHYMPWFEGKEYSGYWGSHWRMANKNPDNMDSEGKREIAAHYYPLIGPYDSGDPDVIAYHLLLMKYAGIDGVLIDWYGSHKVLDYAANLDNSNALIAALDTIGLNFGIVYEEYTAEKVETRKGITAIEAAQTDLLYMEENYFSNDRYITIEEEPLVLTFGPRFFRKADEWTEIFSVMEKKLKFLPLWNHGNLVGAANTAGEFSWIDFNYTLSELDKFYAKTNQGVTVGSIYPGFHDYYKEGGWGESYGYVRHLDGMTMRSTFDLAKDSNLQFLQLITWNDFGEGTMIEPTQEYEFLFLELIQEFSGVPYTKAELELVHTYYLKKKAHKGDPDAALKLREIFTLLNELEPAKAEQILKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B6</accession>
    <name>A0A654E5B6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025367">
        <property type="entry name" value="DUF4271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14093">
        <property type="entry name" value="DUF4271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="360" mass="41051" checksum="534B787C9197D204" modified="2020-04-22" version="1">MRALFFVFSFFITMSVFSMADTLVMRDLAVAWRTFDGKGAVSEYVKHENDIVFFELPKGSDSEKLLIGSDEPVDIWMNERLVKHNFSGLVTYTPDSLVVTFGSPIRVTIYQKGGIGKTLVTQMAEIRTGKGAVDPLHPRLEGFEHNAYLIILTILVLFTGVYRRLFPISFSHSFQTPLTFKMRSLSAEESYMSFGSIDNLFTGLYFSGLVSAFFSYSGVYPFREAPVSLAGSLWTWLFSTLLVFAFVLLKYGWSRLLSLIFDFKGVSNIHSQDFVSLFILVMAVCLGISAIDFTLFDFVSQTLKSGAILLLVLAVIFYQLWIYFKFDKYHSHRKLMIIVYLCTTEFLPGFLIIYWLVKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D8</accession>
    <name>A0A654E5D8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AbiEi_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiEi_1" evidence="1">
        <location>
            <begin position="67"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="30435" checksum="5037300740750BF1" modified="2020-04-22" version="1">MRAREYIKHLLSIENYSFSLEEITGQTDSTDTSLKFELARLVEKKEITNLRKGFYLIIPPRYSKQCYLPIQLYIQKLFQSLNRNYYLGFYSAAKFHGASHQQTHREYVMIEKPKLNEIKKNDFDIKFITASQWPAKNILEKKSDAGYFNISSPALTAADLIHHQSKLGGLNRMLAVIEELAEEITHEDLKDLLTWYPHRSTIQRLAFILDEQQTGIDLKIVSNYLKSAQYFPVLLSPKKNQKAGSVDNIWKVDVNIELESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I1</accession>
    <name>A0A654E5I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter (DMT)-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="142"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="31194" checksum="CA0F58C31B1DBA39" modified="2020-04-22" version="1">MLLVGLLYGTNYSIVKIITPEYILPFGLIVIRVAIATACFWLIGLSVNEKINWRADWVRIVLCAFFGVGINMLFFFKGVSLTTAINGSIIMTLTPVMVFVTSLILLKEKVTLLKVLGLAVGFLGAFLIIYSPGTGISLGNWRGDVLILLNAMSYGVYLVLVKPLMTRYTPISVAKWIFFFGFLLVLPVGWNEFTQIEWQALTAKVYFSMAFVIIGVTVIVYVLNIWALKKVNPSTVGVYIYVQPVFATLIASTFFGEILSIRHLIAALLVFAGVWLVVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5N9</accession>
    <name>A0A654E5N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025039931" evidence="1">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14087" checksum="0C7DF8E841061F89" modified="2020-04-22" version="1">MRKLLLIPVFVLVAMCIHCDDCACDPGPFFGELKVRFTINEENPEVLLTIFEGKIEKQDTLFSEWVTESPVYYDLQAGKYYSATVTYSKGIRQIVAVDGKKMTIGSDDCDCDYAENLSLNLKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E613</accession>
    <name>A0A654E613_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="206"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="505" mass="57405" checksum="3B416A8003130CFF" modified="2020-04-22" version="1">MKKIILKILKYGLIVIGLILSIILLLYVYPIADPLSQKTDTNDYIISNINIIDVANDSIITNQSVYIKNDRIVKVTSKDSLLKNDHIKIIDGKGKYALAGLWDMHSHLAFQIAPQVIMPLHIANGVTYIRDMQGIVNINKERIQWRKEIDSEELLGPRLIGFADEIVGANYDEQNVFELVNRTAKDSQTFIKIYSGILPDRYFPLAEEAKKQGVVFAGHYPNAINPIDASNAGQRSFEHAHLFLKHANPLAKKNRQYYQALYSDEEVDEDDRPSSIDMLASFDYQKFSELVDTMVKNNTYFCPTHITRKYEAFANDKVFLDDANLKYIPHLVSLIWKDDISQMKEYVEVEGNQQYLEDFYLKGLELTGLAHEKGVNILAGTDSYDPYSFPGISLHSELEELVKAGLSPAEALKSATIIPAEYFNVSEMYGTIAENKIADLLILDKNPLEDIKNTTSIESLFFNGNLYEKEDIDNMKLYVENNASGLNGLSISVKMFFRLMKDNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E614</accession>
    <name>A0A654E614_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tsaB</name>
        <name evidence="2" type="ORF">MARINOS108_60162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="25428" checksum="5C6378BC2C34A7C7" modified="2020-04-22" version="1">MSTILSLDTSTKVCSVAIHQEGVLIGHQAYHLQKSHSNLLPGIIQQLAENCEVSLSDLTAVALSAGPGSYTGLRIGTATAKGMAYTLSIPLIALDTLDTMVAQVAPMLKGEELLCPMIDARRMEVYCKLVDHSGAEIWETQPLIVDEHSFDDFQQESIYFFGNGSDKLEQLFGGVDRYHFIRDIHPSAAHMGEVAWAKFQHSAFEDIAYFEPEYLKEYRTNVPSQKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6D3</accession>
    <name>A0A654E6D3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024925423" evidence="1">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="259" mass="29283" checksum="9B0FBF04FAB9D8B0" modified="2020-04-22" version="1">MKSFIGILFILFLASGMAHGQEAPLFHSSFEEQAFASGDPIQILLASDDQVDHNKYSAYRDEIEQLVLKLKNKHRGDKSIALIEKAFYYTHRKSLDWYENYVTLSDLLQDGKYDCLTGTALYAIILSELGVDYSIYEFDFHVFLVASVNGDSVLLESTDPYYGFVNRSDEISEHINQYLTGEVSPQNSNVPVGSNGHQYSSHINNRITLNELAGLQYFNLAINAFNQGEVELASSLLNKANLLYPSQRIKEIQKVFANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6G2</accession>
    <name>A0A654E6G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="23422" checksum="A649E6748709864A" modified="2020-04-22" version="1">MNVLDPALLKFSSLKHFLLSFELDSGHTVKRLIALGFLTLFLLYHIGYLGYYWYSMKQINEEWLVRVDVTPDMKHISIPITLPYWSDQSEYRPSHGSITINGKQYRTVLEKYSQDAIHLIVAEDYAVQELNQSISDWIKMMNTSDSEHSGKVNLLKSIAKDYLADTHDLLPEKLFKLTETSFFSTSDMLTECYSTITTPPPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6I2</accession>
    <name>A0A654E6I2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="8" type="ORF">MARINOS108_20358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="17156" checksum="5A30931A2730287A" modified="2020-04-22" version="1">MATALKNLSDNKTSGIRDISGAKFGIVVSEWNEEVTEALYSGAFETLMALGATREHIERMNVPGSFELSLGAQWMAKRNDIDAVITLGCVIQGETRHFDFICQACANGITEVGLKYDKPVIFGVLTTETQKQAMDRAGGRHGNKGDEAAATAVKMLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E795</accession>
    <name>A0A654E795_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4136" evidence="1">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="22377" checksum="82F44CF9ECEA661E" modified="2020-04-22" version="1">MKNLLIITSFILLSGCMAEREFIVEYDYSYRGKFKRYDTFNFLNLGDTVNYNGLSDSMIKREIERRMISQGYKKSDKPSIYIAYKVFSNDMSFKGYEQLELESWDALYAERAENENNLEYIREAKYTNKAYELKKGTLLIDFVDRKSNGVIWQGYASGLFDDRTYFSKDVRYSVRSILNQYRLLAASYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7V7</accession>
    <name>A0A654E7V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exo-oligoalginate lyase</fullName>
            <ecNumber evidence="2">4.2.2.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alg17C</name>
        <name evidence="2" type="ORF">MARINOS108_11987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052764">
        <property type="term" value="F:exo-oligoalginate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alginate_lyase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="741" mass="83249" checksum="C1BA80420577D0AF" modified="2020-04-22" version="1">MRFKIYITIVFFFILSKSDGQTSPSLILTKDGIKEIRQGLGRVALFDQTLATVQLEVDAEIEKGIDVPVPKDLAGGYTHEQHKTNFFTLQKAGVLFQITGDERYAVYIKDMLYAYLELYPDLDRHPAERSYARGKLFWQCLNDANWLVYVSQAYDCIYEWLSEEDRQALNDGLFKPMADFLSIETPQFFNRIHNHSTWGNAAVGMIGLVIDDQELVDRALYGARSVSVKAGAVDNDGGSIVAQDQEMGFLAQINHAFSPDGYYTEGPYYQRYAMYPFLIFAEALSNKRPDLKILAYKDSVLIKGVYALLNQTNSAGEFFPINDSQKGMSLASRELVNAVSMAYHYGSQDLSLLSVIASQGRVPLNDAGFDAAKAIGEGLARPFIKPSIELSDGANGDEGAIGILRGGDLTLVMKYAKHGMGHGHFDRLGFMLYDETGEVIQDYGSARWVNIEHKDGGGYLKENHSWAKETVAHNALVVNKDSHFDGKVKEADKTSGTPYYFAAGQSVRIVSAKETRAYDDVEMHRTMAMVDLEELEHPLVIDLLSVQARAETRYDLPLYYVGEFMSSNQQLQTNNDLTPMGKESGYQHLWAEAQADLTGDLYSMTWFNKKRFYTLTSVIQSGDQMIMTRIGANDPNFNLRRDPGLIHRRTGVNTVFASLYEIHGSYDYSTERPLNLFTSIADLKVLHQSAEYVVVRFQLNSGEEYQLAFSLKDDSESSQHAVKSAKGQCTWQGVYEFKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8T2</accession>
    <name>A0A654E8T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="28285" checksum="F8F50E1B5BBC072B" modified="2020-04-22" version="1">MNLHFELKKGTRKGTMVFLHGNSSSSKVFNETFSSSIDHTLIRMDLPGHGGSPKNPQSYAIDTLRTMVIDFIIEKVTEPFLLIGNSLGGHLAIEILPELPQCKGLVIFGTPPLKKPINAEEAFLPCEALNTYFKADYTDDELDETMAVATYGPAGRELLRDDFIQTDPSFRSTFYNGAMVEGSLHDEVAIIASDSRPVYVIQGVQDPTVNVNYIRGLQGITKIFEINKCGHYASLEEPYQFNSILKKVSSEVFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9C2</accession>
    <name>A0A654E9C2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025491">
        <property type="entry name" value="DUF4382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14321">
        <property type="entry name" value="DUF4382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4382" evidence="2">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="31673" checksum="FA987323313D83BD" modified="2020-04-22" version="1">MKTQFLVSLLAGVLILASCEEGANDSMKSVRGNAAMRIVLVDDPAAYDAVLIDVVGLEYKHELDSIEDEDLEDEEGNSEDQEESESHWVTVEIEPMVFDLLELNNGNEALLADIDIPEGELKEVRLILGANNHLVVDGDTVELKVPSGNSSGLKIKIDADIEEGKEYKLVLDFDASRSIVKAGNSGKYNLKPVIHATLLALDEEDEYGAIEGMIWPDTVSSVVYVIHDEDSVSTIPEETGYFLIELLEEGDYEIVAVPEENSGFNVTTMSGVNVMSGVVSNIDTLTLEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAC3</accession>
    <name>A0A654EAC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16156" checksum="61D53E3858000B32" modified="2020-04-22" version="1">MVIAEEKNDLDRALKIRSEVFVKEQGIPPHLDHDADDASSIHLLAYADKELIGTGRLTEVPASGWQLARIAVIKSYRGLGIGRMIIENLENIARSKNARRVFLRPHKHLQSFYEQLGYQLINDEVIRIQSFELVIMEKHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB40</accession>
    <name>A0A654EB40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein assembly factor BamD (BamD/ComL family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="852" mass="98401" checksum="96641963CE97F80C" modified="2020-04-22" version="1">MRINLITYFILITLLVAGCSYSSGPVSTAYQNVTAHYNAYFIANELMNEIEQSVYDNYQWNYNKVLPIYVPIDSNDAKSLEAQIEDCIEKASIAIQRHPNSRWEDDSYILVGKARYYSLEFADAIETFKFVNKHSENDDARHAALIELIKSFVDFNEINNAIAVSDYLKKEKLNNKNKKELSMVRAYLFQKRKDLDQMVQHLVAAEELMTKYSDKARIDFIIGQVYQQLGFEAEAYNYYESCLKNNPVYELAFYTKLNMAQVTQVTSSGDIKRTQKYFKKLLKDTKNTEYKDKIYYEMANFEVKQGNLDQAIAYYKESVKSSVKNKRQKAYSYLKLGQIYYDSLKNFVLAQNYYDSTVSTMPRDEENFEKIKQRQEILNDFVKQIVTIQTNDSLVSLSQLPQDSLLALATAVATEQHEKEAAKRKKEAKRASQQSTVFDQQGGDLIGANLAPGATWYFYNTTAVGKGVTEFKRIWGSRPLEDNWRRSLKAGGEIATVAEGEALAKKEASAETEGDDAIQTMVDEMLASVPSSQEEINKLLAQVEEAHYNLGNIYNFKLDENANAIETFETLIARFPQTEYKAEVLYQLYLLYKGSNIELATLKSDELKRDFPESIYAKLVDNPNYREESKAATEQLKMVYTKAYKLYKSKDYQKSKYLLDSAFNLYPENSFSDNIALLNVLNMGELEGQFKYQYELNNFIKTYPESELIPYAQKLVKTSEDYQINLYNSAKARFVEYFKQKHYLVVVYPNNDQLTQQIPLEVEEFIKAKNFGLTTGNLILNQDHALVLINEFPAKGSAEKFLTMLNAELSLKDLHKGEKIYSFVITEDNFDIFYQTKDVNAYLNFFEKHYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC21</accession>
    <name>A0A654EC21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="33404" checksum="8F97C1D3AF09902B" modified="2020-04-22" version="1">MYQKLEECPACKHTLLTNYLICEDHAASKESFALVQCKKCSLVITNPRPDQDHIGSYYQHSDYISHTNKANNPVNWLYKQVRKITLAHKTSLIKSHSDQKRILDFGCGTGLFIQHLQKDGFIATGFEPSPQARTIAENLTGLPILDNLKQLDNKTFDIITAWHVIEHVHELRLTLKALRKSLVDDGLLFIALPNHKSHDAQHYGSHWAAYDVPRHLSHFNRVSLEKLAKECKLNLIKTYPMKFDAYYVSLLSEKYKTGKTNYLKAFQVGMKSNQQARKTSEYSSLIYVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC50</accession>
    <name>A0A654EC50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein HU-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="96" mass="10742" checksum="C74CD2A2E0AED6F2" modified="2020-04-22" version="1">MTKADVINEISDKTGIDKADVQVTVEAFFTVVKNSMAEGENIYVRGFGSFVNKKRAKKIARNISKNTAIVIDEHHVPSFKPSKIFTEKIKSSKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECQ1</accession>
    <name>A0A654ECQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase/DNA gyrase B/HSP90-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="401"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="604" mass="68358" checksum="D54A0FE2F9286FFE" modified="2020-04-22" version="1">MKKLIILLCVLLIGCELSDDPIGPMLPESASALAFVDSINQHFYKLHSQNFENAKVQTERAIAISRANAWPDKEALASKNLGVVLYMQGQYEPAQVAFLRSYNLYDSLSDKSGLARVCNEMGAFYRKHGYEEQAMNLWNQAEDLAKEADDLEALGTTYGMKGTFYWLKKQYDVSDAYYFQTYNIRMEQGDSVGLGYVLVDLADMEQRKGNLKGALSYMEQSNLIRRLIGDEQGVTDNHKMIGDLYMDVGDYATAIPFYQQCAKESLQLGYPDLARKSYDSLASAYSLIGDYQQAFGHHVLAEDLEDSLFNLEKSKIIDELRTKYETAQKEKQLAQKDLTIQRRNLLTAGLGGGLVLLIILGAQYIQRQKLVHQNQLTLEKSRFKEAQIEAAISSQEKERTRFAQDLHDGFGQMISILNLNLKSLENEKYDRHEVFQESAKVLEDMYRELKGICFNLMPQTLIKSGIMAAVREFAARVNTTGKISLETDFFGLEKRLSEVQEISLYRITQEWVNNILKYSDADQVSIQITTDQEEITLMIEDNGSGFDAEVLRSGSGNGWRNMTSRANLIKGELELDTTPGLRGNTLIVNAPVHFLSHHQNEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ED59</accession>
    <name>A0A654ED59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="10225" checksum="41B3E7E37D5FB78A" modified="2020-04-22" version="1">MKFTETAIEVGSKFYTRMITESLLLSYNFNEPSGSNFHIREIYYSISKPDILVTPIFLFTPIDQAKIVCSNGEMLRKRFNAVARCSYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEF8</accession>
    <name>A0A654EEF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="42887" checksum="7D325CCBB5854E33" modified="2020-04-22" version="1">MRIGVTYIVSNINKSLAFEWIAKDLDHDKFKLSFILLNDHSSDLEKYLISIDIPVKTMKILSFWSKILTFLRLTLYFLKQKPEIVHAHLYEAGYMGITAAWCAGVKCRIYTRHYSTLHHHYFPKGKLVDSWINRRATKLIAVSENVRQVLTGLEGVPASKVKVVHHGFELSGFSEVLERDVAALREKYTIPKESFPVVGMISRYTHWKGIQFAIPAFRKLLQIYPDAILILANANGDYKKEIEDILDKTLEERNYREIAFEADIQSLYQLFDVFVHVPIDNHSEAFGQIYVEAMAAGVPSVFTLSGVAGEFVIHKDNALIVDFQSEDAIFEALKELLGNSELRNQISISGSATVKESFSLKKMISSLETTYQTQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSH8</accession>
    <name>A0A654DSH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009833">
        <property type="entry name" value="DUF1398"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036696">
        <property type="entry name" value="YdfO-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07166">
        <property type="entry name" value="DUF1398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160419">
        <property type="entry name" value="SSF160419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="14504" checksum="639A6E07BDB22464" modified="2020-04-22" version="1">MFTIEQLKAAHSKVKSGADFPTYIQEIKLLGVTHYVAYVGDGHIDYHGPNHYAVKVPPKYNPLPIADSPNYESFKDGLAAHQQGQTDFLTFIRMCAQFGIEKWAINIDTMTCTYFDQAGIEVLVEDIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTG1</accession>
    <name>A0A654DTG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16361" checksum="1DE5A25A95A027F3" modified="2020-04-22" version="1">MEKEPKVTGIGGIFFKTSDPNATKDWYRQNLGLVTDQYGSSFEFRNTNNPDEINYLQWSPFTNDTTYFQPSPKEFMINYRVQNLEGLLVKLKAAGVTICDEIEEFEYGKFVHIMDLDGNKLELWEPVDHVFTEMLDGKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTK1</accession>
    <name>A0A654DTK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6106" checksum="4544A014A40BAB32" modified="2020-04-22" version="1">MTSRVNTSLEFITKNIGPFHNFIPSYALKEVWHTIITTLTATTLPAKSELPSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS0</accession>
    <name>A0A654DTS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032304">
        <property type="entry name" value="Peptidase_S8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16361">
        <property type="entry name" value="Peptidase_S8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024975582" evidence="5">
        <location>
            <begin position="28"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="505"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="6">
        <location>
            <begin position="2203"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2487" mass="269691" checksum="6C0D24C72F079248" modified="2020-04-22" version="1">MNHFLPFKTNRILLALIFTLCATLSWAQKIEPGVKKGIVKVKFSPEMTSSLQQMTVTSRKNELVTGLKPFDATANQVKASDMYRLFPVNSATESKLHKHGLHLWYILEIDEDINPKAAAAQLMLLDEVEVAEAERIKVIAPYEVKAYVPSSSTSRQASLPFNDPLLGDQWHYDNTGQTGFSDADVNLFEAWTSVTGASDIIVSVHDEGVDVNHEDLNSNIWVNEKELNGQPNVDDDNNGYVDDIHGYNFQRKSGEIDPQYHGTHVAGTIAAINNNGIGVSGVAGGDGSGNGVKIMSLQILGGAAIEKSFVYAADNGAVISQNSWGYSYPGSVEESVLDAIDYFIAEAGDFEGSPMKGGIVIFAAGNSNYDADWYPGYYESAFAVASIGPEWKKASYSNYGTWIELSAPGGATEYGAKNGVLSTIPNDQYAFLEGTSMACPHVSGIAALALVNSPAQITNTELWNKLQTGVVDITAFNPGYEGLLGSGAIDAALAIKNDLGKIPATISDLTVTGIAQEFATLSWKVPADEDDGAPVSFTLYYHTAPINSANLTAASRHIIKNTQSAGSDVAFEVNDLLGLTTYYFAITSTDRWGNVSELSEVISETTNEGPSIAVDENSLQIALNVDASGSLTASHDLTILNEAAGVLRWEYFTRHSNSSLAYGADRLNYPTSTATKKASAAKVAQRNADDNQDKLRGQSPETYSFTPVVKSYADWATNIIGETDINLSNSAATKFIVSETEGFNLTQARMYLKHDPALGPVIMEVYEGDTPSKENLIYAQEHSNWSADESWAYITLNEQLYFGSGSTFWLVFHVPAGNLFPLGIGYETDPKYSEYCFMSFDLGGTWAPLEDLLDSKEFTFAVAADSYNEHLGTYLTLDPANGDVEGNSEMNATLTANGSTLINGTYNANLVLASNDANQRELRVPVSLNVSGHQPRIVHTDIVDFGSVFIGTSETVEIVLDNQGFGNFNNPSFNIAGDQFAIDGYAPWQIQARGEVTLKLNYQPTTSGNANGLLTITNGDQTYEISLFGVGAETSEINITPTEQVVNNVAIGDVINAEVLVKNTGGYPLKYFIPGFDTKGISNDWPSAYHTYGYKYKTSDPSETNPIAYDFQDISATGVDVTETIKDDGAYYEVNMGFDFPYYGESLKTLYIAQKGFTTFDNSVRPVNTPTLNNFYSPKGYISPLGTFLDFSAQGQVFYQVEADRVIVQYHNVTDGFNAPITAQMVLHSNGDIRFYYEEMGFDSWSQSYLTILIEDLNRTDGILVHNYEQKISLYSGLALGFDYPGPNIISSIENASAILAPDSSALVSLSLNTSTLVEGTTKRYINIISNDPANFQTSALVQLEITSGGTPLPVVSMDTVEFGEVFQGAVRKAVFTVKNEGTANVNITGMAFANDAFSLTGTQPATIKPGLYEKYEIVVPTTTTADLEDVLTISYSGGSTSTIYASAAVVDPPAINADLSVVQQTLAYGESATEPFSVENTGLAPLSVTMTGKQWLSFDTETPGTSHGYAYQKYNAGEFYQWIDIRKTGTQMPFAEDLFDKAYFWRDLTLPFPVTIYGEEYETIKIGENGIVSLEEDPEVMFFNDAIPSVTYDGTFIMPYWTFGGFDTYFFPEDEVGIFYQFYDDKIIITWSYLVNNFGGMGDPISTQLILYKNGTMKFQYKVEEFGSDLTSTFTAVGIQESSANGVGISNQNNLDHGSGLAYILVPAETYTVAPGTSLTGQIGMTAQNIYGGTYSESLKIQTNVPGSENLEKPVELTVTGDAVLALEETVDFGSKMIAMEWGSPLSNYLDLEMANEGSAQLEVSWAQMKSGTEGLSLQIWALVDGWFGPEWRWADISELYSPWAWVTPTFTINPGEALETRAVFAPAYSGDFRDTLVLTTNIGQFDIIMTGTGFEPPAMTVTTEKVEVVMNTMDEASTGSIVFGNTEGLSALQYEVSIDYGRAGATATTYQRTAAKPATVALQSESSQHSLTNKARTSATYNRILNHTDKEAPDTYIGIGGGAPFTLATRYNAGEQGFNISHVETWFKPEAATEGKLMVEVRAGGTDISEAILLAKGEVTFTGSGDDEVGAWHQIALEEPAGIYPNEDFYVLITYPLGIQFPQGSVTGQETVPGRYYFFDEGSWYNLQQVTSFETMGWLMYAAEETAGDAAWLTITSDLNGEVAMGAESTINLAFSGALAKRGDQIAEVVITSNDPNNPEARIPVSLHMNEAPMFGKVPASLFVQENDTLVVSFEVTDKENNTYTVTPAEEYPNLSFAEANGLITLTLTPDYGDEGTYSYTLVATDEHGATAEVTLVAEVAHTNQAPGYIATEPLVQIKGQAIEYAIGDFFSDPDGDAFTFTVTSSESSIAEVFAAADKFLISSKVIGETSLTFTATDVHGAVSVETINLTVGAVMGTAKEAEAYGISVFPNPTTSKLHIQLPDENRGTSKVRLINLLGVSVMEMSGDFAASSVTTLDLTRVPTGIYFIEITDQTGTYTTRILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTU3</accession>
    <name>A0A654DTU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maebl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="166"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="27706" checksum="15278F887A12880F" modified="2020-04-22" version="1">MDKDHNLAVLIDGDNIPSAYVKEMMEEIAKYGNPTIKRIYGDWTKPNLSKWKNMLLENAITPIQQYAYTTGKNATDSAMIIDAMDILYSGKVNGFCLVSSDSDFTRLATRLREAGMTVIGIGEKKTPNPFIVACDRFIYIEILKKAEKTTQDPKGKPAKKDEDDKITPKVISLISATISDCADDDGWAFLGDVGGLLQKKQPNFDSRNFGFQKLTPMIKSINKFEIEQRENQRGGKYKLVYVRNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTX1</accession>
    <name>A0A654DTX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="20618" checksum="F417AE2FFDE8C2AC" modified="2020-04-22" version="1">MRKIKLFIATSLDGFIAQPNDDLSFLKLVEKEGEDYGYAAFTSTIDTIIIGRKTYDYVVKEIGASHYDNGKRDVYVITSTERPDNGRIKFHTGNLKDLVTKLKSQEGKDIYCDGGAQVIHELLKNDLIDEITISVVPVLVGNGTRLFKEGRPEQLLQFVSAKTFDTGLTQLYYKRKRKSDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU09</accession>
    <name>A0A654DU09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="26509" checksum="8F12BFB3FDDB4ABB" modified="2020-04-22" version="1">MKPFFTIAFCLTLTITQAQYFIPAMDNSEIGMSKEAYVVTNAGDTVRGRVLSAMIMSGQLRSFTIKDADDNKQKFKSTDVKLLAVKPSKLSNISSAMSVPNLSRAMEVDFSDIIDREWVYFEQALLPKKKDKYVMMQLLNPGYDSKIKVYLDPNANQTMNVSAGGLNLAGGEDKSYLVVYDGNKSEVYKKSGYKKDALEKLYKNCPVFTENYEGEKFKWSNFAEHIYVYDQLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU30</accession>
    <name>A0A654DU30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024842515" evidence="1">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="261" mass="28696" checksum="F9384F27EE3F2115" modified="2020-04-22" version="1">MRYLLSLSFLTLFLGVSGQSTTEESLQVGQLYEFTASKIAAITDQKYVDDANGRTPYDVSSGYMVIIDHLSNDSVYYSYLNFSDQSLYNTYNTPVTWVMSKKEFKEITRPLYSRYKGAKVGVYTVPFRLRGVGGGGEPFDFESSLSLTANLVFGVGSRKEKHSTVDGSLGLGLTSIGLDSLNSEVPENRTASAFTLSMGVVLWPNEHINFGAFVGWDKLGLKDRSTDWIYDGKTWLGLGINIGFEALTTDKNAKIGGNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU48</accession>
    <name>A0A654DU48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinate-nucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="480" mass="55114" checksum="A2D860718E7C533F" modified="2020-04-22" version="1">MASIDMESFKKLTTKEKALSLNLDDRIYGTIAEIGGGQEVADYFFKAGAASGTIAKTMSAYDMTFSDAIYGKSERYVCEDKLMRMLNREYSLLSQRLTQRAKRSHFFAFANTVETINYKRTNEGHGWIGLRFQKHPNSDPNDCVIHVILKDNDPLWQQQVLGMVGVNLIHACYNYAEPEDILNSLIDNIHHSRVEVDMFKIEGPDFHHVDNRLMSLKLVKNGLTHAAMFDPKGKVLQPSAVLYKKNIFVLRGRFRPVTHVNVDMMLTGMRAFRNESDVEIKNIMPLVELTLNDLTMEGEVDETDFLDRVDLLCSLGQNVLISNYQEHYKLASYLSKFTRHKKLGIVLGYYNLQRIFDESYYENLKGGILESFGRLFGSNVKLYVYPAIDANSKEIVTSENFTPEVHLKNLYQYLKDNDQIEDVQGAKTENLHIISDDVLRMIENGEVGWEKFVPNKVSDAIKDHHLFNFPYEVPLDEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU77</accession>
    <name>A0A654DU77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the drug/metabolite transporter (DMT) superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="166"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="314" mass="34282" checksum="3C1556E9A2A859E4" modified="2020-04-22" version="1">MSQQALSHRFLIILAFLCIYVIWGTTYLAIVVGLEGFPPFLMASIRFLVAGLMLVGYSLFKGEGFPKKSSLVKNAFIGLVVLAGGQGLLIWSEQHIASGYASVLVATLPIWFVVMDKKHWKLYFSNPYILSGVALGFAGIIILFRDKLSEPLPAAQIHLQLVASVAVLFGGMCWVMGTLYHRSRPAPGTLYQNLGWQLLCGAVICLLISLSMNELDTFAWSQTNLTSWSAVLYLSVAGSIMAYIAYTWLLNEMPSAIVGTYAYINPVVAVFLGWLLVGEVITTPQMVGMLIILVSAVLINLNRGKIKPVAKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL3</accession>
    <name>A0A654DUL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="20652" checksum="170483EB2B3F1E52" modified="2020-04-22" version="1">MLKKILISLGVVVVLLVAAYFYLDNRNRTLSPRGAANLTNGELTVDITYSRPSVRDRLIFGTEEDEALQPYGKYWRLGANESTEVTFSQDVLLVDQPVKKGTYRMYAIPGPQYFELRLNSELGEWGAFEADSELDILSVMIPVLPSEHTEQFTIALEPLYDTGVKIVFKWDKIKMEVPVITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX7</accession>
    <name>A0A654DUX7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="50174" checksum="8DFB819758671084" modified="2020-04-22" version="1">MCAHCQTPEQSRQLESSSLVQATQPEWMKNAVLYEVNIRQYTPEGTFSAFQKHLPRLKELGVDILWLMPIHPIGKEKRKGTLGSVYAVQDYYAIHTDMGTKEEFRALIQAIHEAGMYVLMDWAASATAWDHVLTKSHPDWYLHDDEGNFITPEHNSQSDVIALDYNVAALREYMKNAMTYWVTEYDLDGYVLHVNDKVLPSFWEDVRKTLESVRPVILLADAPGHSVPTGFDIVSGWELEKAMQAVSRGEVSAAVIRVFIQSQLDSTSNRGIRMLYTSNHEKNAEEGSVFERFGKAAEAYAVLTYTMQGIPMIYSGQEVGLNHSLSLTEKDEISWGDHPFNALYSRLNKLKKDNPALWNGAWGGRMELLTTSNPDQIIAIYRVKDGNRVLAVFNCSPEEVRFTVDAQEYQGDFKSFKSRSTATLTGKEAMTLPAWGYEVYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV65</accession>
    <name>A0A654DV65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HlyD family secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="68"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="448" mass="49296" checksum="EDC815CE995B11B3" modified="2020-04-22" version="1">MAKKKKSNNKILYILIGVVVLLIVFAMVGKSQGWVGQKKAIEVEFGKVEKATIVEKVSASGSVQPVVEVKISPEVPGEIIKLSIEEGDSVTKGDFLLKIRPDNFMSVLERTRANLNQQKANLADAKAREARAKANYKRAELEYERQKKLYAEKVISDADFQLSEANYNVALQDLESATQNVEAAKYIVQSSQASVNEALENLRLTEIEAPMSGIVSKLDVEEGETVVGTSQMQGTEMLRIADLSNMEVRVDVNENDIIRISEGDTAIIDVDSYSYMDKTFKGVVTQIANSANTKVSSDAVTEFEVRIKILNSSYQDLIKENGMKYPFRPGMTASVDIITETKRDILTVPLSAVTTRKANSEGEEDAEDSETSLDQELDEVVFTVADGKAVKTIVKTGISDFERIEIVEGLKEGDEVVSGPFLAVSKRLKDGDGIEAKKEEKKEGDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF8</accession>
    <name>A0A654DVF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="902"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1421" mass="161931" checksum="FF44AB82995A4843" modified="2020-04-22" version="1">MLSHIVHKQFPQILIGHIREPQIKDISTLCARTDSSLTARHFVSKARSIFLPKLRLIVQIIAFSAFSITSGQTYKFDHLALEDGFTTAFVDAIAQDADGFIWLNTWEGLFRYDGYVFKHYKYLAKDSTIINSTALHLDSKGNFWVGTHTEGLLLYNKEHDSFDYADLKPEDLTSLRSHTISAILEDHLGNLWIGTNGNGLKVRRNGKENFEHIPFNDQGNPRSVRGEKVRIIYEDSKGRIWVGTGNYFESMISGGLNRYDHSTQTFHHYTYQPPQFKGIKPNRVQSIAEDSNNNIWIGTAPDGLYTYNDEKDQLVEFKYDLSPDKLDVMANKTISFIHEHRETNTLWVGMFGAGILTIDLKSSKATHHLLNQNDRFSLSHNSVWCIMEDRQGLLWVGTVNGLNKVNPKLKLFPKFSTLESGTFSRIADVVLSIYEDSNKTLWIGTRDGLTRSRNSDNNFQRFREDSSNPNSIKGNSIRGITEDDLGSLWIGTNKGLHKFIPESESFNHYPSSDQNPLLPKGENIFDLMTDSKGNLWIGAQMALNKYNPYTGIFNKYYYPDSVVCDCGGTLYEDQGGNIWIANDNTEVMKFDESTRKFTHIFDREVMIYQFLEDSKNRFWICSNTDGLGLYNRATGDTKFYGVLDGLPGKTITGVEEDDRGYLWVSTNNGIALFDPERNLFKSFTPASGLPVSSPKNPYKNKDGELFFGDVSGFTRFDPDSYDFDTTASDVVLTQLKIFNQIVRPSPESVINQSISVTEEVRLAHDQNDLTFDFVGLHFVAPKQNRYKVKLQNYDKDWVDLGNQHSTRYTNLSPGVYEFKVIGANSDGIWNGKASSLHIIIAPPWWKTWWAYLLYGTILICLIYLWRVYDLRRIHLKNQLELKSMEAEKLATIDQMKSRFFANISHEFRTPLTLILGPLKDLIYASKNTSELDQYHLIKRNADRLNVLINQLLDLSKLEAGSVKLEVEQMDLHAFLRPLFASFSSLAQSKHITFRSIVPEESFEMLFDADKLEKIISNLLFNAFKFTPEGGEVSVSITKDTKRSVKSRGGEKEYIEIVVKDTGQGIPGDQLETIFDRFYQVDDSHKRAFEGTGIGLALTKELVDLHHGKIAVKSKPGVGSSFTVRLPISLAPLDQGEKAKIPSTRDHPPKIVYQAEEHEVEQEIELHDNENIILIVEDNQDLMKYIKHHFENNERINHPRILEAANGLEGLTMAIEAVPDIIISDLMMPEMDGLELCHQLKNNEKTSHIPVIILTAKADQQSKLEGLEIGADDYIAKPFEAEELILKVANRIEQLVHLKKRFSQFIELGPKKISIKSIDQRFLEKVQLIIDEHLTESEFDVNSFGQELGMSRSQFYRKLKGLVGQSPNELIRNSKLIRASQLIEQNFGTVAEVAYAVGFNNLSYFTKCFKEKFQKLPSEYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI4</accession>
    <name>A0A654DVI4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EamA-like transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="15639" checksum="E50D2505B194EE76" modified="2020-04-22" version="1">MNKLMWVIMAFISGAFLPIQAGLNTKLGKAGESPVHASTISFVVGTVALLLYILFTQQSVSWEGIKSAPGYVWIGGVLGAFYVTVIILAFPQLGPGLTFGLVVAGQLIISALLEHFNVLVAQQQSISPMRVLGIVLVVVGVVIVRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ9</accession>
    <name>A0A654DVJ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hisC</name>
        <name evidence="5" type="ORF">MARINOS108_10387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37685" checksum="4FF5ABB3530C15C9" modified="2020-04-22" version="1">MKAYSSARDEFEGEAEVFLDANENSLGSATEVLYNRYPDPHHKALKQRWSEIKGISTDRIFFGNGSDEPIDLLIRLFCEPRQDHIITMPPTYGMYSVSAAINAVENVLVPLTPDFRIDFKELKEVWNGSSKLLFLCSPNNPTGNLLSREIILDILKSFPGIVVVDEAYIDFSSEPSWIAELEHYRNLVVLQTLSKAWGMAGIRVGVAMGDPFVISMLEKIKPPYNLSLANQTLALEALSHETKKIDQVKILLEERDKLKAVLADLLLVQEVVSSHANFLLVRFERSDELFDYLIGHKVIVRNRTKELHCKGCLRITVGTPAENSRLVGLLHSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVP4</accession>
    <name>A0A654DVP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="23"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="245" mass="26718" checksum="E5EDD45041EADAA3" modified="2020-04-22" version="1">MKILVCITHVPDTTSKISFTDNNTKFDKTGVQYIIGPYDDYALARAVELKESSGGSITVLNVGEAETEPTLRKALAIGADDAIRINAFPRDAFFVAKEIAKAAQQGEYDLILMGRESIDFNGGQVHSMVGELMGLPSVSPVMVLDIEGNTAKIQREIEGGKEFMELDLPFVAGCQEPIAEWKIPNMRGIMSARSKPLNVVEPSTDDKATEVEVFELPPAKSGVKLIDPDHLDELVNLLKNEAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS3</accession>
    <name>A0A654DVS3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">menD</name>
        <name evidence="6" type="ORF">MARINOS108_10823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032264">
        <property type="entry name" value="MenD_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16582">
        <property type="entry name" value="TPP_enzyme_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M_2" evidence="5">
        <location>
            <begin position="239"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="564" mass="62858" checksum="D9BBA463DB78E862" modified="2020-04-22" version="1">MISQTVFDTSRILSLKGVTHVVLSPGSRNAPLTISFSRNPDIKIYNIVDERSAGFIALGMAQKLRQPVVLCCTSGTSLLNYAPAIAEAWYQQIPLIVISADRPPEWQGQRDGQTIHQVGALGNFVKETFELPAQTEHEDLAWEYSRKLNEAVNLSTQLPQGPVHINIPFREPFYPQPNDQLTFSDHPWVISPHYSELSPDFSSLAEAWQHFDKRLIVPGQQPLTPELNEALGRLTGEAVVVGDVISNISGQAAIRHHDLFLASVEGKLAESLQPDLLVTFGRSVISKNLKIFLRKNPPKEHWHIDEAMVSADPFQSMSKLIQAKPERFLAAMADSKGDLSDFSFQIRKNFAQNWAVEDSKGERRLTESFENMKFSEFLAFAKVIKLLPDSTDLHVANSMPVRYVNFIQGLPKGTEVFANRGTSGIDGTNGTAVGGSLVSDRLTVLLTGDLSFFYDRNAFFHHYDLSQLVIIVFNNGGGGIFRLIPGPSALPELQQHFETRHTHSARFTAMEYGFDYYQAKDAAGVEKAMKSIVKKGKTPRLLEIFTDPETNNEVFAQVKKAFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW15</accession>
    <name>A0A654DW15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="5192" checksum="5C751C6D7E66FEA3" modified="2020-04-22" version="1">MKIFQENIEISGHDLTRRLQKDLKEYSFLSERGKKSQFEKAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWC1</accession>
    <name>A0A654DWC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">MARINOS108_11255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="17100" checksum="44476471280994D7" modified="2020-04-22" version="1">MKKTAIFPGSFDPFTKGHEDIVLRSLELFDEVIVAMGHNSNKKRYFEVDFIIGKINAAFEGDERVKVIVYDELTAILAQKYNARYLVRGLRNTTDFEYENSISQINKYLNAGLETVFLITSPDLAPISSSIIREVHRYGGDVTPFLPYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWD3</accession>
    <name>A0A654DWD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pyridoxal phosphate-dependent aminotransferase EpsN</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">epsN</name>
        <name evidence="4" type="ORF">MARINOS108_11369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="391" mass="43140" checksum="9EA9D7284EADF4AF" modified="2020-04-22" version="1">MSPDRIYFSPPYISETEIAAVTETLRQGWIAPVGPQLDLLEQSLAQKFHFPHVLALNSGTAALHLAVRLAGVRAGDRVIVGSFTFVAAANAVRYEQGVPVFMDSEPDTWNLDPRLLKSHLSEQAGKPTFPKAVIVTHIFGQPAKIKEIADICAEYGVKLIEDAAEALGATSITGQFVGGEGDFGVLSFNGNKIITTGGGGALICKHAEDHEHAKHLASQAKVPANHYLHEEVGYNYRLSNVLAGLGLAQLSRFDAIMERKKAVFDDYHQALESLNWLTPKVVQGANCWVYPCVMDHEIGVDELIRRFEEANIEARRFWRPLHLQPLFSDAGYVGGSVAEDLFRKGICLPSGAGLTSEEMERVVEVLERFRLYFPLKSPGGRKNSNFRFKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWF0</accession>
    <name>A0A654DWF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="14519" checksum="69DD4BCD8970CAF0" modified="2020-04-22" version="1">MEQKKNNKAMHITLWIAKGLLAAMFIMAGFMKATQPVDALAESLVWVTSTPLGLVRFIGVSELLGGIGLLLPAILRIKPFLTIWAALGIGAIMLLAAIFHGSRGEFEAIGFNVFILAIALFIAWGRSKKAPISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN4</accession>
    <name>A0A654DWN4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024819037" description="Cadherin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="851"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1661" mass="178416" checksum="E0B75F2127123385" modified="2020-04-22" version="1">MKYSVLVVSVLIALNFSTAQTFTKSESLSSALTDIGFSNIAWGDYDQDGDEDLVINGISNAGNTCEIYRNEGGTLLNIEAEIAPFYRGSMDWGDFDGDGDLDLLITGMSDNGPLSIIYQNTNGVFQDIEANLIPIGQTGYSDARWGDYDADGDLDIAMSGSNIDFENDAYIYRNDNGVFVDTETNLEQIAGTVHWIDYDLDGDLDLFISGDGYFNIEARLYQYNNGTFTDTEFAFTGLTNAYQDWADYDGDGDPDLLISGQTVDLDVVCFIYRNDISNFINIEATITGTLFGSVQWGDFDADDDLDILIAGDTTGQGTSIARIYENINGTFYALSEEFPLTYYGEVKWADYDNDFDLDVLITGLSEEFSAPFSEFWVNSTDPNFGPDSLHLSNLKVNLSAGENTLIGDLSSHDLNASDVLTFSLVYDAQASGVYNGAFHISENQLYVNNTRNMWAGTFPIIIGVSDGELTLTDTFNIQVVDDIIPIDEFVLDSANSAMLPNLFFSEADWGDYDGDGDMDLVITGTPATTSIYRNDEGVFTNIEAGLEMAEDGPVRWGDFDGDGDLDLAVGGSSKIYRNDEGTFVDIEANIVEVSSGAMAWGDYDGDGDLDLALSGITASSDKISKIYRNDDGIFVDTDSPLTGVSYGDLAWGDYDNDGDLDLALSGDGRFILYTIIYLNTDNTFSETISLEGLSESALNWGDYDNDGDLDLLAAGRNIDLTPRTIIYQNQNNTFVDTEAILPGVSFGHAEWGDYDHDGDLDILLVGDTGNSEYISTVLRNDGDGFTDTQAYLPQVTFGVAKWADVDGDSDLDVLVTGLNEISSDFALTQYWLNTINPNRSPSALRLSDTIVLQSSGENTQVGLLSTEDADADNLHTYTLIEGEGSTHNSLFKIQENALIILNAHLAAGEYFIRIQVSDSGGGTFENTLVVAVIDDVPPILIPSDTLFYLDQTGAVTLTANNIAGESYDPYSGTITMSMERGNFYCEDVGPQEVSISATDAHGNTTSEQVTISIADTLSPKVQDGALTLYLNAAGAAIITSDQSMALVSDNCGIMSTSVSQSEFSCENLGTQEITVTTEDHSGNSTQAPIQVTLLDTLAPIASLKTATVELKADGLTTMTFADLDNGSLDNCGIESSILSKDTFTCEDLGENQITITLEDASGNVTTATTLVTVTDPAAPVAHLQELTLDLNDLGTVTISSEDIDDGSTDNCGIESFILSKDTFTCEDLGENEITVTLEDASGNVTTATTLVTVTDPAAPVAHLKELTLDLNDLGTVSISSEDIDDGSTDNCGIESFILSKNTFTCEDLGKNQITITLEDASGNVTTATTLVNVTDQMAPAAHLKELTLDLNDLGTVTISSEDIDDGSIDNCGIESFVLSKDTFTCEDLGENEITVTLEDASGNVTTATTLVTVTDPAAPVAHLKELTLDLNDLGTVSISSEDIDDGSTDNCGIESFILSKNTFTCEDLGNNEVVITLTDKDGNTTVGSTIVTILDRTAPTAILQGLTIQLDPLGTAILTPEAVDNGSSDNCGLDQIKLSKETFGCDDIGTQEITVTLTDLSGNETSEVVNIIVVGNCDPLHMVGELEMSIWPNPADQLLRVSLRKDYISHTLRLSDVSGKTIANFPISQELMELDISALNPGIYFISIQGRGAQLIKFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR5</accession>
    <name>A0A654DWR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein TolC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025045298" evidence="3">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="473" mass="53066" checksum="3E81C25E7D37BA5D" modified="2020-04-22" version="1">MKGKLTLLFLMLSTWLVAQETSGSFTLDDCVEYALKNSVDAKNALLDEQIATARVKETVGIGLPQVSGSVSVQQSPTQPRFFTQYTAGGGSFFITDEQASQMGLSDGDVVALRNIFQLKGAGDANLSINQMIFNGSYFVGLQASKAYKELSVKNSNQTSEDIVMSVSKAYYNLLIAREQLSLVNANLNRLDTLYRNTLAMYENGFAEKIDADRLKVTLNNLKVNRENIENLNDLSMRLLKFQMNFPFDEELTIGGSLEDEAMQKVELPEAENWDYSNRPDYQVLQANYELQKLNIKNKYAEAIPMISAFANLGYSTQSPNFGGLFATNTDFEDQNGVGPDKWYGYSTLGLSLKWNMFTGLQRNYQIQQEKLSLSKIENGFEVLERSIELDIKRAQDNLDNALSRLEVQKENAELAEYIFNISQIKYQEGVGSNLEVIEADTSLKEAQTNYFSALYDAIIAQLELKKALGILYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS8</accession>
    <name>A0A654DWS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Ntn-hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010430">
        <property type="entry name" value="DUF1028"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06267">
        <property type="entry name" value="DUF1028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024871408" evidence="2">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="326" mass="35493" checksum="2195FE7BC5F622B6" modified="2020-04-22" version="1">MRKIVLSCISLMVFWVANAQYNKEHPLVHTYSIVAYDPETGDLGVAVQSHWFSVGTVVTWAEAGVGAIATQSFSNPAFGPQGLALLKTGLNAEQVLEALIKSDEGEAYRQLGIVDASGLAASHTGAKNIPAAGHLVGGNFAVQANLMDNDKVWPAMAEAYKNAKGPLAERLIVALEAAQAAGGDIRGKQSAAVLVVSGQPTGKLWLDRKVDIRVDDHAEPLVEIRRLWEVHQAYEYMNKGDLAVEAGDFVAASELYEKAEGMFPDNLEMQYWHAINLANTNKMSEALPMFKSIFKKDEHWRTLTPRLIKNGVLNVSDDQLQAILAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWW6</accession>
    <name>A0A654DWW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="17463" checksum="6792312A77531941" modified="2020-04-22" version="1">MSYIEKHLYLSPATTMFSKACEYGIRATIYVAVQSLEGKRASLKSIAAEIESPVAFTAKILQDLVRKGLMQSVMGPTGGFEMDQQKLDSMKLSQIVDAIDGDSIYKGCGLGMKQCDESKPCPVHDKFAKVRADLREMLESTNLLGLATELETGSTFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWX1</accession>
    <name>A0A654DWX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OprB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007049">
        <property type="entry name" value="Carb-sel_porin_OprB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038673">
        <property type="entry name" value="OprB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04966">
        <property type="entry name" value="OprB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025076187" evidence="2">
        <location>
            <begin position="22"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="412" mass="45799" checksum="33E29E2F65BBAFAD" modified="2020-04-22" version="1">MTNLKNLLLVFCSLTSHLVVAQNSSSDLLEYEIVYSALPWANLSGGLDQGFVYMDNADVTAKLNINELFDWEESLSIFFYGLGNHGGQATDYMGDFQVASNIQAAPSWRLFEVWIQENFLNDRLSALFGLYDLNSEFDVLRPGTIFINSSFGIGAEYAQSGLNGPSIFPISSLGLRLSSSITDQWRVRLAILDGVSGNPADLKSNRIALSKEDGALIAMEHSVYLSSAVPDRINRNYTTRRKKVGRDRDIPTNDKINVGGWMYTAEFPELGDSTFYRPNWGAYIGAQKYWFYSKYDDRYLSMFVRYGVANDRINRIGSAISGGIVFAGSLSEKTDYVGLAFSTAINGKARLEHSPEDERAETALELTYSFPLRTWLTIQPDVQYIINPNTDASIKNSLAIGLLIQASLGGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX03</accession>
    <name>A0A654DX03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="25440" checksum="E5FA2822E7F059BF" modified="2020-04-22" version="1">MASIGTFEGKNVLVVGGSSGIGKATLSKLREQGAEVYNVSRSPCHIQGVSDILLDVLSDFSVIEGMPDRLDGLVYCPGSINLKPFQGLKYEDFLRDFEINVLGGIKVLKACVKNIKAAESPSIVFFSTVAVTQGMSFHSSVAASKGAIEGLVKSLAAEWSRSGIRVNAIAPSLTDTPMAQNLLSTDEKRKASEERHPLKGISTAEELAGTVMYLLSDVAHRVTGQVIHVDGGMSSIRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX07</accession>
    <name>A0A654DX07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="15772" checksum="D378B65863C465DB" modified="2020-04-22" version="1">MRQSKEYTVLYVDDERANLRSFKSAFRRIYNVIIADSPLEGIEIIKENKINIVVSDHRMPELIGTDFLRKVYEHDGNIRRIILSGFVKKEDLQEANEEFGIHAYISKPWDFDHLQGIFERLLTEEKSEHIIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX17</accession>
    <name>A0A654DX17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-glyceromanno-heptose 6-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="306" mass="34940" checksum="E17AB2B7D71D329B" modified="2020-04-22" version="1">MNVLITGGAGYLGTELIKELSKNPEVKEIRIYDNLSRDNYALFTGHKYDNKENISFIHGELLDSRKLRKALEGVDAVFHLAAKVTSPFANTDPHFFEQVNHWGTAELVYAAEESGVKHFVYSSSVGVYGSSSSEMDESTNPNPRTFYAISKHRGEEHVSRLSEKMKTHIIRCGNIFGYSRSMRFDSVINKFVFESNFSNRISIHGNGKQYRSFAHVDYVADTFNRLLTSSVPSGIYNLVELNISVLDIVDVLKEVNPELEFIFINQHLKLRNIKVSTDLKLAGFMELKEKTDFKEIIRSFHDRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX51</accession>
    <name>A0A654DX51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4296 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025381">
        <property type="entry name" value="DUF4296"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14129">
        <property type="entry name" value="DUF4296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4296" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="13561" checksum="D1CBDA1CDC8FBC28" modified="2020-04-22" version="1">MKKSFFVILIVLLGSCSKKQTEIPADVLSHDQMVRVLIEVHLLEAKVKKLYIKGDSSQKVYNHFEKMLFEEQEITREQYRRSMEFYVEEIENYKAIYDEVVDSLLARQKAKDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXN1</accession>
    <name>A0A654DXN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="58"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="360" mass="41259" checksum="017E86D21675F598" modified="2020-04-22" version="1">MNRIFILMSFCTVLLYTSCESHKEHHHEETKFLVTSPIRMDTSITKDYVCQIRSIQHIELRALEKGYLQNIYVDEGQFVKKGQLMFQIMPRLYEAELRKAQAEASFIEIEYQNTKRLAESNVVAPNELALAAAKLEKAKAEVALAEVHLSFTQIRAPFDGIMDRFHVRLGSLVDEGELLTEISDNSAMWVYFNVPEAEYLDFESNVKATEKTVVKLLMANNKLFAHEGVVETIEAEFNNETGNIAFRATFPNPKRLLRHGETGNVLMTTPLKGALLIPQKSTFEILDKRYVFVVDEENKIRSRAISIVAEMPHIYVIQDGLDENDKILLEGLRLVRENDEISYDFMEPLSVISNLELYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD3</accession>
    <name>A0A654DYD3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">MARINOS108_12072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="37905" checksum="38131019DBD1F61B" modified="2020-04-22" version="1">MLTLIQYNDPGYLTKENLSPSEAATLVKEDFINWIDVEITSQTYVDDTAGLFNIHHLIAEDILNTDQLPKFELFDDHLFFSTKMLSFDADEDQIMEEHLSVVMCKSLVITFQEGLPGDAFNELRKRIQLSKGLIRKYKEDYLFYHILDAVVDHYLQIMETLRTRIEQLEARSLADPSYDVMQQVIEIKKDINILRKYTVPMRDALNKMRVEADHFIQKSSINYFQDVADHLLYLITSFETSREMLKDLMDLHRSNQNSEMNRVMKTLIVVSAIFIPLTFLAGVYGMNFRYMPELNSQWGYPLTIGAMVGVAMIMALYMRIKRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP8</accession>
    <name>A0A654DYP8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acyP</name>
        <name evidence="7" type="ORF">MARINOS108_11504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="89" mass="10259" checksum="3AB62D1EE8B974A6" modified="2020-04-22" version="1">MALEIRCFGKVQGVFFRASTKNLADDLKLKGWVQNEVEGSVLIHAEGDYKKLAELLEWSKEGPQFAVVNRVESWEAPDEDYPTFEIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYQ8</accession>
    <name>A0A654DYQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="105"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="285"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="528" mass="58748" checksum="9AB6618398641F17" modified="2020-04-22" version="1">MKTIKLIIISIVTLGMVSCEDFLSTEPLTTVTDANYYKTPSDAYTALVGCYDGLQTVWAGGVALPLAAEVMSDNCFGGTGASDAYNFQAIDHFDVSLAPSYQNLYGDNWTAYYRAVYRCNVLLSKMDQIEWGTEENLQAIYEAEARFIRAYLYFDMVRMWGNIPLITEPTTENLPQADPADVYAMIAGDLIFAIENLSSLPYTSQDPATYGRVTKWAAEALLGRVYLFYTGYYDETDLVGVVNQSQALSYVEDVITNGGFGLVEDFANLWPAASVENYAGEDNKETVFAIKYTFTSDYNGNTDGNHWLVMYGLREQSFYPYGNGWGGGTVNPKLWNAYADTDTRKIASIISVEDEGLDFDLDRQREYTGYTNKKYTPMSDMDGNSVAVEMGGTNFMIGQFQDYVSIRYADVLLMAAELGSGNAQTYLDMVRQRAYGDNFTPLAVTPVSIMKERYLEFALEGIRYYDLLRQGLDTAAEAIEESTTVTNAGVVEPKTITTAKFRETKGLMQIPNSQITLSSGVLKQNTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ36</accession>
    <name>A0A654DZ36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_12163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="30989" checksum="7E2490B1224CEAE4" modified="2020-04-22" version="1">MEEQVNQITDLSAIAMEYAWEYGPKVVLAIITLIIGLWIISVLTRGFGRVMEKRNFDRSLTPFLKTLLSALLKVMLFISVIGMVGIEVTSFIAILGAAGLAVGLALQGTLQNFAGGVIILLLRPFKVGDVIDAKGYTGTVKEIHIFYTIINTFDKKVVYIPNGTLANSDMTNLSQEEDRRNEWKFGIAYGDDVDKAKTLLRKFIDEDERILKEPEPFIAVHSLGDSSVNLVVRTWSKAGDLWPVYFDMNEKVYKEFAKEGLNIPFPQLDVHMHNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI6</accession>
    <name>A0A654DZI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe-S_biosyn domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="11732" checksum="1835D8919437DC4A" modified="2020-04-22" version="1">MINVTDKAKERLAELRIEEGHSPAHNVRVAVKGGGCSGLMYDLLFDNTLTESDEVFEDKGVKVIVDKKSMLYLLGTTLDFSDGLNGKGFQFINPNASRTCGCGESFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL1</accession>
    <name>A0A654DZL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="28529" checksum="CF28FFDF87BD31E6" modified="2020-04-22" version="1">MQTENFHPGLSIDCVIFGFHENELKVLLLKLKKDDRWALPGGFVEKDKDVDSEAVRVLKKRTGLDHIFLKQFHLFGDVDRIEPSHSDTMVKKGVIPPELKGWFDQRFVTVGYYALVEYSRVKAPTPDLTSERCDWRPLSDLPPMMLDHAQILKKAHQTLKKELNDQPIGLNLLPEHFTMPELQALYETVLEKSLDRRNFRRKMLSYDILIQTDLQRKGGAHKAPLLYKFDKEKYNNAILSGLQSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT8</accession>
    <name>A0A654DZT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_110051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024877112" evidence="1">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15869" checksum="692BE0707FF54C7E" modified="2020-04-22" version="1">MNKRRSFFNKSLLSLAGLSLMPTILKATQKDKVINGRFIHMVFFWLKPETDIADFQRATENFLMQVPEIVNYHLGEPAGTPREVVNNTYSVSLVVTFASKEDQDIYQKHQAHLKYIEENKDKWTDVKIFDSWGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX7</accession>
    <name>A0A654DZX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="5364" checksum="9F09D18A139197C1" modified="2020-04-22" version="1">MLRLKAIRIYKTKIRIVKKSNLVSNHHINYRFWSKKNGIDKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX9</accession>
    <name>A0A654DZX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Galactokinase</fullName>
            <ecNumber evidence="10">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galK</name>
        <name evidence="10" type="ORF">MARINOS108_11904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="9">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="7">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="8">
        <location>
            <begin position="286"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="388" mass="42744" checksum="BF04A9800BAEDE56" modified="2020-04-22" version="1">MNDLSQRVSSHFAEQFGAKPVLVRAPGRINLIGEHTDYNNGFVLPAAVEHAIFFAIGKSDNADRCSLISLDFEDRYDFDLADMKPLATDSWQNYILGVVAEIQKSGREVAGFNLVFSGNVPRGSGMSSSAALECGTCAGLNELFELGIPKVDMVKMSQMAEHHYAGVKCGIMDQFASMMGAKDQALLLDCQSLEYRHFPIGLNDYSLLLCNSNVTHSLASSEYNVRRQQCEAGVSGLQKRFSGISSLRDVSMDQLNQVQSQLDEVVYRRCKYVIEENARVNEFTTALTQSDLIKAGEILKSAQKAMKDEYEITCPEIDFMADFANAHEDILGARMMGGGFGGCTLNLIKKGREAAFIEALNEAYMDQFNQEITPIQVNISDGVSLIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZY6</accession>
    <name>A0A654DZY6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">argH</name>
        <name evidence="7" type="ORF">MARINOS108_110056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="36"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD15882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="49210" checksum="F2F2C367C1AD40EF" modified="2020-04-22" version="1">MKLWQKSTDVNKRVEAFTIGNDQELDLLLAPYDILGSLAHIEMLESIGLLTGEELKVLSAELKQLYQLARAGELTIDPGMEDIHSQVEFLLTKKLGEVGKKIHSGRSRNDQVLVDLKMYFRGEIEEIVGLVKSLSDTLLSQSERYKDVLIPGYTHMQVAMPSSIGLWLGAYAESLSDDLIALRAAFDVANKNPLGSAAGYGSSFPIDRMKTTALLGFEEPNYNVVYAQMTRGKSEVALATAMASVAATLSKLAMDVCLYAGQNFGFLSFPDELTTGSSIMPHKKNPDVFELVRGRCNQLLSLPNELNLILSNLPSGYHRDLQQLKEHLFPGIQTLKQCLDIVDFSLSQVKVNPDVINDSRYDYLFTVELVNQLVLDGMPFRDAYKEVGKRVEEGTYRPDREIKHTHLGSVGNLANDQVAEKIKRELSKFPFIHIGGCFSSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0F0</accession>
    <name>A0A654E0F0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose synthase/poly-beta-1,6-N-acetylglucosamine synthase-like glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="50"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="485" mass="54798" checksum="C9403B722CCA44A7" modified="2020-04-22" version="1">MEWIVIFGYSFALLIISLFSLEQLYLAFLYRKGKKNHVHKPLHEFPLVTVQLPIYNEKYVIERLIDCVCALDYPKDKLEIQVLDDSTDETSDLVVAKIAEWTEKGINIRQVIRSERIGFKAGALQYGLQKARGEYIAIFDADFLPDSDFLLKTLPAFEEGTGMVQTRWGHINQEYSILTRMQAFGLNAHFTVEQGARNSSGKFMNFNGTAGIWRKTCIEEAGGWQHDTLTEDLDLSYRAQLKGWKFQYLEDVTSPAELPVLVTAIKSQQYRWNKGAAETARKNCVSILKSSQSFQVKLHALLHLFNSSVFLFLLLAAVLSIPVLFVKSTQPVFEIIFNLGGVFIVGFVGMTIFYWVSARAATPHFSLKYYLIHFPLFLTFSMGMALHNAIAVTEGYLGIKSPFIRTPKFNIRSKKDSWKGNSYLTKGIAPLTIMEGLLALYFVFGVVTGIQIQNFGLLLFHTMLALGFGAVFFLSIKPFNDAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0G0</accession>
    <name>A0A654E0G0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_120145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024978791" description="OmpA-like domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="525"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD16334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="641" mass="71003" checksum="99751BCEE9E8C9B0" modified="2020-04-22" version="1">MKKLIQPLALSICMMLTITVQAQDPKVSFLNGNKALSQGNLDKAIADFKEAVNLKNDYQDAWYQLGLTFNYARRWEEAVYSFSRLKALNPNYNPWFYYEACRALIELDKLPDAQNAATAFLEKYPNKPKDQLSRHQALTKLVYARESPGLRMLPKSMTDPVPLSAINSPSGDYMPQVNPTGTRLYFTSVRQGGFDNLDDSTRMMDFGEDLYFSILENGTWSAPKLLPEPLNSMGDDFGSAFTGDGQMMVYVRCGDKESIGNCDLYITQLVGTDWSEPMNMGNVVNSDDWDSQPTISSDGNRIIFTSARTGGYGGSDIYMVEKNHLGEWGVPQNLGGTVNTPFNENSPYLAPDGKTLYYASNGHPGFGGMDIFYCIFENGKWSKPINLGAPLNSSGDDTNFSISAEGMGYFSSSRLNGEDYEIFQIELPDHLKPKPTVVVQGIVSNAKTSAPLEAVVLIEDINSGELISVNKSNSSSGEYLVVLPAGRDYSVSASSKGFFFYSQSFELPKDTTYQEISLNIMLEPIEKGTKVVLNNIFFESGRAELKPISYVELNKAADLLKDNATMIIEVGGHTDNLGSDELNLSLSQKRANAVMEYLKLAGIEETRLKAKGYGETQPIADNSTEEGRAKNRRTEFEIVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I6</accession>
    <name>A0A654E0I6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsK</name>
        <name evidence="9" type="ORF">MARINOS108_120473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="14043" checksum="2F609B9E91DD5BF8" modified="2020-04-22" version="1">MAQKRKDKAKKRVVAVDALGQAHIQATFNNIIISLTNGQGQVISWASAGKMGFKGSKKNTPYAAQVAAQDCSAKAYEQGLRKVEVFVKGPGAGRESAIRTIQNSGIEVTIIKDVTPMPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I7</accession>
    <name>A0A654E0I7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024996353" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="269" mass="29804" checksum="2A414CEC4C899550" modified="2020-04-22" version="1">MNRSLTSFLLLLCSLACLAQEYTTLTNLPYRNQTERNSDPYISERCVLDLYHPASSGFATVIWFHGGGLTGGNKELPEALQQKNIAIVGVNYRLSPKVRAATCIEDAAAAVAWVFKNIEQYGGDPSKIFVSGHSAGGYLASMVGLDKKYLQAYGIDANDIAGLIPFSGHTITHFTIREERGIPGHQAIVDELAPLYHVRADAPPLLLITGDRELEMLGRYEENAYMMRMMKVAGHQQTTLYEMDGYGHGMTYPAFPLLLNEVKRIVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0S6</accession>
    <name>A0A654E0S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5777 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045916">
        <property type="entry name" value="DUF5777"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19089">
        <property type="entry name" value="DUF5777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5777" evidence="1">
        <location>
            <begin position="33"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="32850" checksum="2A2B31479F40CD74" modified="2020-04-22" version="1">MYKHLFMRPILLILLTLWTSVVFSQTEYAYEIFDDTRVVNGHSVETNLEGVLTFIISHRFGTLNRGAYEVWGLDNATMRMGLDYGLTNNLMIGIGRSTFEKTADGYLKYRLLAQSSGDRTVPVTITLLGTTALKTLKRFDGIDPTFQQKLSYTLQLLISRKFGPRFSAQLMPTYLHRNLVEDDEQNDILSLGFAGQYQLSKNWSLSMEYYATPGSALPDGSGASPEYSQSMALGVQIDTKGHVFQLHFGNSRGMIEKFFVAETDGKWQKGDIHFGFNITRDFTVKGRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V0</accession>
    <name>A0A654E0V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024813002" evidence="1">
        <location>
            <begin position="21"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="578" mass="65943" checksum="BD76AFC609DABCD0" modified="2020-04-22" version="1">MKYLAILVGVMFGLLGNLHAQTVTIDDVNPENLEIKAFNLSKNATVKISGSGGVFRDDYRLLLYYGWILDADTREVVWHLFDEMKDHEFRKSDGVYDFSVELPLKPGNYELYFTGAYDTRGWGNNFTMSDWTIDSFDALVDEIFDSRDKEKFRRSLQDDLMISVSGSGVSSVSVDALFDAKVKKAPVYFLKAENKERFEQGFTLTASTDIRIYALGEGRKDEIFDYVWIYNAASRERVFEMNYKNTDFAGGADKNLRVDEQITLPAGSYIVSYRTDDSHSFEKWNALPPDDPQFWGVALFPATEADRKNFATFKAPKSMQPVAELVKVRNHALVSKGFSLSKDMDVRVLCLGESSSYDDMADYGWIVDANTRKTVWKMRGYKTEHAGGASKNRRFEDVLTLDKGDYIAYYTTDGSHAYNSWNAASPHEEDRWGMTLWATNDNEVGLVTTFEVEDFVTKNLIAELLMPSDNAYLKKIFVLDKDTKVTIMAIGEGSDNRMYDYGWIKNMNTGEVVWEMDYYDTDHAGGARKNRMVVENLRLPKGEYRLNYETDGSHSFNDWNADPPNDPQSYGIRVLIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y1</accession>
    <name>A0A654E0Y1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ORF">MARINOS108_120487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="13405" checksum="7088B86A6737E5CF" modified="2020-04-22" version="1">MIQQESRLNVADNSGAKEVLCIRVLGGTGKRYASVGDTIVVTVKSAISSSSLKKGTVSKAVIVRTKKEVRRKDGSYIRFEDNAAVLLNANNEPRGTRIFGPVARELRERQYMRIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E150</accession>
    <name>A0A654E150_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13570" checksum="88302E601F991DD4" modified="2020-04-22" version="1">MQPSKPRVIKDFEKLDENLQEQIKLAYPYGFYDSLIHFYNKDGKKVSALPFETDDRYYMVRMTVAEAKAIIEDDEDFDDDGNLKDEIKDDYESKYSDVSYMSDYISDDEPTDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1B4</accession>
    <name>A0A654E1B4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hutH</name>
        <name evidence="8" type="ORF">MARINOS108_20039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="525" mass="57237" checksum="0B15993D7D8FA530" modified="2020-04-22" version="1">MDMKHPFQFGKDTLTPGIALRIARGQQTGTFADDTINKIKKSHADVAEIANGDRVVYGINTGFGPLCTTIISKEQTRKLQENILRSHSVGVGAYVPLEIAKLMLVTKLQALSFGYSGIALETLERIKWHLEMDITPMVPTQGSVGASGDLAPLAHLFLPLIGLGKVTYKGKIQDSGDVLQQLGKAPIALGPKEGLALINGTQFILAYAVRGLVRLHNCLELADIIGAMSLEGILGSASPFQEKLHALRPFQGSLHVAHRLRTLLKNSQMVESHENCGRVQDPYSIRCMPQVHGSSRNAWHHLKELVNVELNSVTDNPIVFSSTDTISGGNFHGQPLAMPLDYATLAAAELGNISDRRTYLLLEGDIEGLPKLLMKNTGINSGFMIPQYTSAALVSENKSLCFPASADSIPTSLGQEDHVSMGSISGRKLNQVIDNLENILAVELICAAQAFDYRKPMKSSKILDACHEVIRGRIDHAEEDRIFADDIEKAHDMIVNESIIDAAYQTAQQNNINLKGDLYELFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1C6</accession>
    <name>A0A654E1C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="326" mass="36569" checksum="2D57CA8E83E26A8C" modified="2020-04-22" version="1">MSLLETRSLSIGYSQKTAPQKVLQKDVNLSINPGEIISLMGQNGVGKTTFVKTISGLIPKLGGEVYYQNDQLEDLSANDLARRLSIVLTEKPYSHNISVLELIAIGRHPYSNWMGVLRAQDKDAIDWAINETHINYLADKKLYELSDGQLQKVMIARALAQETDLIILDEPAAHLDLYNKIEVMTLLRNIAQKGKGILISTHDMQISTQLSDKLWLFNFNEPVQQGAPEDLILDGTLEKTLYLQDYGYDMIHGSIHIGMPENGTSVALEGPEDVLFWTTQALRRNGIKISQSADTTISCSQREWIVRSSESSQHYTSIGELLTYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G9</accession>
    <name>A0A654E1G9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22101" checksum="5F817C80BBBB150F" modified="2020-04-22" version="1">MNILYFIDLLGTMVFAISGALTAFDKKLDIFGISAVAFITALGGGTLRDVLLGSTPVSWMQNLNYLFMILIGISIAILFRQAVQKLRKTFFLFDTIGIAVFTILGLQKALDFGVSPIIGIMMGMISAVFGGVIRDIVCNEIPLIFRKEIYALTCIAGGIVFMLLDFWAVEQFLNILITAGFIVSFRVLAVRYHWELPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I0</accession>
    <name>A0A654E1I0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="32882" checksum="715D58D2A6508415" modified="2020-04-22" version="1">MSLSLIHILNPFDSQSTDQQRIQEVTFQSIANALTHGTGHLKVRVCATRYSEDVSPLPKYMTELPNLSRSVLDFGDFNPKRRYPLIADILAEAVKLNGDYYIYTNMDIALQPSFYDFVSEQIRKGNDAVIINRRRIPWGYANKEVSEMYLLKGKKHPGFDCFVFSKAIAEQLILGHICVGIPFIGVALAHNLFAFANRLAFYDHARLTFHLGMEVMPPRQPDYYWHNRREFFNNVKPALWPHFDVSSFPYGRDWLPIRLVRWGLNPSLFIWMNTKLLLRKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J8</accession>
    <name>A0A654E1J8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="37797" checksum="6DA7FEB0B8846E4F" modified="2020-04-22" version="1">MSQAVEPLLKENPNRFVLFPIQHNDIWQFYKRAEASFWTAEEIDLSQDPKDWASLNDGERHFIKHVLAFFAASDGIVNENLAEHMVSDVQYTEAKFFYGFQIAIENIHSETYSLLIDTYVKDPKEKDSLFHAIDTMDCVKKKADWALRWIDKGNFQERLIAFAAVEGIFFSGSFCSIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYNNHIKHKLPKETVTAIIEDAVIIEKEFVTDALPVKLIGMNADLMCQYIEFVADRLLMELGCSKVYNSTNPFDFMDMISLQGKTNFFEKRVGEYQKAGVMDSGTGNNDDKAKFSLDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q1</accession>
    <name>A0A654E1Q1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="20988" checksum="784BD375871E6ED7" modified="2020-04-22" version="1">MSEQTLTNKESLALITEMIGQAKKNYRKGGSFHFLLWGWVVMLANLGHYYLEGFTDYPHPYLVWVITFPAGIISGLYGARQSKQATVVSHLDRLYGQVWIAAGVGIVITLIFMRNLSFNHGAMILLFAAMGTYLSGQMLRFKPLILGGLALAVAAVVCFNVSVTDQYLVSAIGIFLGYIVPGYLLKSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S5</accession>
    <name>A0A654E1S5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024897251" description="Histidine kinase domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="428"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="648" mass="72629" checksum="7D6643AD04D19641" modified="2020-04-22" version="1">MNRVIRFSLCLSFYISSLFAGAQGLSLVDSLKSMLKNPPNDSVETRWVNSLFGLYMSIDMDSALYYGQQAKALAEELQDSVLIASNTLNFGGYYWYQSDFIKAMECYVRAAEIFDKLGSETDKADAQLNIALIYMTMGEGAKSKPLFYKVFEVYKRNNYLNGLSTAYQYLGAVFQDEANYDSAIYCFKNCIDYAIKSKMVLNQAWGYSGLGEAYLKKGMYAEARAYQLKSLQIEEQLGNRVGMLQSYIALGSLEKQMGNLSMAEQYFVKAESMPELSGDLISQRNLSQEFVKLYETTGEVAKAYEYYRKHVAAVDSIKNSQDLATINELNEKYESEKKANEILTLQRESELNRLILDKERSQKLLFGGASVLFLLLSGAMIFGYFQLKKSKNQIDKQNKLVTKINKALNKSQDELLAANKTKDKFFALVAHDLRGPVTSMQGIGRMLSFYRKKGDEERIDQLIEQVDQSSASVNHLLDNLLKWALSQTNGLNFQRGAFETKGLVEECMTIFDEGIKAKEIAVSVEMQGGLMVEADYNMISTVLRNLLSNALKFSPVGGTIKLSVSEREDYAEITVTDSGQGMPEETIRKIQGNEPVESTRGSQGEKGTGLGLVLCQEFIRLHGQQLHISSSSQGTSISFLLQLAHQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E238</accession>
    <name>A0A654E238_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacillithiol system redox-active protein YtxJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ytxJ</name>
        <name evidence="1" type="ORF">MARINOS108_20329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022551">
        <property type="entry name" value="BrxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11009">
        <property type="entry name" value="DUF2847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04019">
        <property type="entry name" value="B_thiol_YtxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="119" mass="13529" checksum="CB9FB72EABA96C1F" modified="2020-04-22" version="1">MTEMNWNPLTSIDQLEEINTLSQTQPVVIFKHSTRCSISAASLSRLERKWDLQKAGDVKTYFLDLIAYREVSNKIAELYGVDHQSPQVLIIQNGKSIYDNSHFGISFDEIVENIKPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E247</accession>
    <name>A0A654E247_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neutral ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102121">
        <property type="term" value="F:ceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="PTHR12670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Ceramidase_alk" evidence="2">
        <location>
            <begin position="63"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="460" mass="50796" checksum="CF9AE4EBB61777A6" modified="2020-04-22" version="1">MIRMTLKLFAILLVLIGALAIATLTVVDRNHYEKRPFYREMDLRLDSLAEAFALQPNQDSLHIGWSRVNITPTEKVPLAGYGARDPKEMTGIHDSSFVRTVVFQKGSQKVAVVTADLLIIHPELSRAVWRGLPAGWSSDQIYFTASHTHSGQGGWAPGTVGRLFAGDFDASRVDFLTSKILQSIQEASDALEPGEIAVGELAVDDLVKNRLAKDKGIEDPWMKVIQLRKGVAKGFLVFYSAHATCFGSDFNQLSGDFPARFNLLMEADSAITFSAYGASAVGSMGPDVPGAHPAGNVEKIAEELRQQAVLFSLLGAGHRQVSALTSFRLSVPLPDPAFKISKHLALRPYLFKWAFGNYPHYVSVMVLGETLLIGMPCDFSGELAVPLYEKARALGYQLVITSFNGDYAGYVIKDEWYDLPKYEARTMSWYGPYAGQYFTEIINRIISTIDENNQTNTPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E248</accession>
    <name>A0A654E248_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030890">
        <property type="entry name" value="LP_HExxH_w_TonB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15890">
        <property type="entry name" value="Peptidase_Mx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04549">
        <property type="entry name" value="LP_HExxH_w_tonB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="33015" checksum="17CBF1D4A0EF8739" modified="2020-04-22" version="1">MRKGRNISKRWLLIALVASLSGCYPDESLNIPEKDNDVTLTELDEYIEEHFTKEYDMAIRYRYVDRYVATGERVTPPRLEVVRPMLDFIEKYWIDPYLEVTNGEVFFRGHVPPEIIFLGGFIYNPDGTVTLGSADAGSRITFTNVNAIDPEDLDWRELQLQTVYHEFAHTVHQRYKLPASFETITTAGYTSAGSWYNLTDAEALIRGFVSPYATSSPNEDFAETVAFYLFDPEFDAHFITLVEDCGTAECEAQNTGKEFIAEKLAAITGHYKKVTGIDLTELRNVIQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E254</accession>
    <name>A0A654E254_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="13"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="162"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="461" mass="51846" checksum="8DE2E0CCF57C32EA" modified="2020-04-22" version="1">MTIPEPCMKQRGHILIVDDDADVLHTARLVLKGHYEQVSTESSPLRLESMLRRESVDIILLDMNFKTGATTGNEGLFWLKKIKAINPHVYVIMNTAYGDIQLAVESMKLGAVDFLVKPWEKEKLLSTVNTVYQLALSNRSVEKLKGRESALTQDIDAGYGQLVSESEPMQTVLAQIDKVAATDASILILGENGTGKELIAREIHRRSQRRDEGLIKVDLGALPESLFEAEMFGHVKGAYTDAKEDRPGRFEIADGGSLFLDEIGNLSITMQSKMLSVLQNRSVTRVGSSKAVAFDVRVISATNQPLYPMVEAGLFRQDLLYRINTVEIELPPLRQRKQDIRLLSLYFLKEYGEKYQKSGLKIEERTHRQLANYTWPGNIRELQHAIERAVIMCDDSVIAAEDILPQRKAQSNETRSLRVEDVEKSTVIRAIEKHGGNLSKAADELGMGRTTLYRKMKKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E2</accession>
    <name>A0A654E2E2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="56" mass="6612" checksum="9506A1E86B459CD5" modified="2020-04-22" version="1">MYQEPNPEKPREVISKLARKNEFKNTHIPDISGHIFVLHNQLWSKELTVGRIQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E7</accession>
    <name>A0A654E2E7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025039350" evidence="2">
        <location>
            <begin position="24"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="436" mass="48920" checksum="E1A085C70A3E2184" modified="2020-04-22" version="1">MNSITKHLLSLAFIVGLATMAIAQPGWNWGDSVDKAKEKNALYTDFVRAENWKAALGPHSWLLKNTPDLNASIYINGAKIYEGLADNTDDKAKTLEYQGKALEMYDLRIKYFNSEADVLNRKAYVAYKYYRDDQPKYKELYDLFNKAFELNGNDVLINNLTAYMDVIRRYKLSGGTITDEEVFEKYTKIKDIIEVKIAEGGKASSLEKQADYVDKLLTATVDVDCDFIQEKLGPKFKQTKDINLAKKIFGLMLQQKCTDSPLAMEVAIAVNEVEPNFGIAKFIGVKAASEGDLDRAKKYYEKAVELTDDNTKKSEVYLSLARTVASQGGKAAARSNARKALAFDPSNKDAYAFIGDLYMNSFNDCKAGESKVKDRAIFIAAYEMYQKAGDSEKMTSAKAQFPSIEEIFSEGKEEGQSITVDCWINESVQIERRPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2N9</accession>
    <name>A0A654E2N9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024983473" evidence="2">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="352" mass="38358" checksum="07F3745C0DDDF60B" modified="2020-04-22" version="1">MKKTILLLIPIALSHFAHAQWVNDENNYTSGQLAIGSSATWAPLTINSVSGANGNVGVSLAFDGTIHPEIGYRFKANGSNYYQVLYNGSHIMWKHYESSNYVPKMSLSNEGNLGLGVASPSSSLDILTKSVSGGEHLIKLKVSDATTDYLTIQNNTGTGGQFIPAIVGFHESDNRLALRLTASTSSSTDNGSNALMIFDSRQINGSSHSAISARPLFQWSNFTDAKMTMLANGNLGLGTESPDSKLAVNGTIHTKEVRVDLNGWSDFVFANDYKLPTLKEVETYISENKHLPEIPSEAEVSENGINLGEMNAKLLQKIEEITLYLIDQSKQIQAQQTEIEALKNEIDQLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z5</accession>
    <name>A0A654E2Z5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4570" checksum="8F763D57523BAC72" modified="2020-04-22" version="1">MDAMAFSFLHSGPQAKNKRKGIVMITVRIHLNFKLLNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E334</accession>
    <name>A0A654E334_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="24465" checksum="AE7325720857D38E" modified="2020-04-22" version="1">MEKVTFELFGLTLLEPLSTLMNWVLASLCGILYTRLKGSEEPFKKYWSWFFLAYSISLVFGGFSHLLFEYVDMPGKIPGWSIAILGGVAAEYAMTLDVSDSKKRQMLINVIRSKFFATLILLILDFSFKWVMVHTAGFFVFVGVLSYQRMKAGATNYKYFLQGMAFLFVMAGVKVAGLDIHPSWFTRDDIAHFLMLAMYWLFYKGVKNYQTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E380</accession>
    <name>A0A654E380_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="48" mass="5525" checksum="467E6CA0371E24A6" modified="2020-04-22" version="1">MNPMFMNNPDFLVKSTLGFFFGSINYVLILKSRVISNILLIKLFISKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E395</accession>
    <name>A0A654E395_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="40" mass="4557" checksum="72804088A292DF64" modified="2020-04-22" version="1">MNYNLSLKNYEGTHQRAYPSRRGNHAGAVATGIRLCQRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J7</accession>
    <name>A0A654E3J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 25">Na(+)-translocating NADH-quinone reductase subunit F</fullName>
            <shortName evidence="25">Na(+)-NQR subunit F</shortName>
            <shortName evidence="25">Na(+)-translocating NQR subunit F</shortName>
            <ecNumber evidence="6 25">7.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24 25">NQR complex subunit F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23 25">NQR-1 subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 28" type="primary">nqrF</name>
        <name evidence="28" type="ORF">MARINOS108_20842</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 25">NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:47748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="25">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 25">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 25">Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="25">Cell membrane</location>
            <topology evidence="25">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the NqrF family.</text>
    </comment>
    <dbReference type="EC" id="7.2.1.1" evidence="6 25"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00430">
        <property type="entry name" value="NqrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010205">
        <property type="entry name" value="NqrF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000044">
        <property type="entry name" value="Cis_Diol_DH_RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01941">
        <property type="entry name" value="nqrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 25" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 25" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 25" id="KW-0274">FAD</keyword>
    <keyword evidence="10 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="19 25" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 25" id="KW-0408">Iron</keyword>
    <keyword evidence="16 25" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="21 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18 25" id="KW-0915">Sodium</keyword>
    <keyword evidence="22 25" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="14 25" id="KW-1278">Translocase</keyword>
    <keyword evidence="25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="25" id="KW-0813">Transport</keyword>
    <keyword evidence="20 25" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="26">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="27">
        <location>
            <begin position="131"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00030032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00030787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="VXD19744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="432" mass="48636" checksum="C07EB927B54FCC8D" modified="2020-04-22" version="1">MSSVIITSIIAFTAVILLLVFILLFAQSKLVQSGPVNIIINGDEANPITTSAGSTLLSTLSGQKIFLPSACGGGGTCAMCKCKVEEGGGDVLPTEVGHLSRTEQKEKVRLSCQVKVKQDMRIEIPEEIFGIKKWEATVVRNYNVASFIKEFVVEIPEDMDYQAGGYIQIEVPECEVDFKDMDIEAHPEEHDQPDKFQLEWDKFGLWDLKMKNTETIERAYSMASYPAEGREIMLNVRIATPPFDRAANGWMKVNPGIASSYIFSRKKGDKVTISGPYGEFFINPSDAEMLYVGGGAGMAPMRSHLYHLFKTLKTGRKVTYWYGGRSKRELFYLDHFFQLEKDFPNFSFFLVLSEPLPEDNWKVKKDIHDKEGDGFLGFVHQAVIDQYLSKHDQPEEIELYFCGPPLMNAAVQKMGEDYGIPDENIRFDDFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J9</accession>
    <name>A0A654E3J9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="215"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="458"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="580" mass="65550" checksum="98D6F12006CEC31B" modified="2020-04-22" version="1">MTLKKFIPSLGTNVPIEVKLFEVTLILTILILYFWLVFGFFSGYENAIMVIYLGGAITYTGFYIAHKRWAVFRMMTVGYYSLLYLLLGLAWLPSGGVMGSIHNMFALIFLSGLLILKPKEFRLFIVVSLTMVLGFTVFEIVNPDAARPYTDERQWMIDIAVSNALMLSVLSFTLFFYKKEYERDRERLKASNISLSREKLRAESADRIKTSFLTNISHEIRTPLNGVLGNLDLLKRTKLSPEQALLLKDMSHCSDILHGLISDLLDITMIEEEGMVLQEDRIDLHMVVSNVIQFFIPKVALKTGNVSINYHSDKRIPKYLRGDLTRVRQVLINLVNNAVKFTDEGEINIRSVLLSKTSRQAEIKISVADTGMGIPEAQRAHIFNRFHRDDNNPSLEGIGLGLSVCKKVVEAIGGEIGLEKSAEKGSCFYFILPFKIEGSKWDDPEIEEPTINKYSHLNVLVAEDQQVNQLVTRKMLRTLGVSNVEIAENGKKVVEMAALKAYDFILMDVRMPIMSGIEATREILKSASSRPPVIVAVTANVTKHEMQDCFEAGMRDFISKPFSLEVLRSSFEKFLGKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3M4</accession>
    <name>A0A654E3M4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025366">
        <property type="entry name" value="DUF4270"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14092">
        <property type="entry name" value="DUF4270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="424" mass="48172" checksum="DDA7BFC27D2A1575" modified="2020-04-22" version="1">MGMFILALVWGCSESSLIGDEFFGDENFQVSYVDSVSLQMYTVKFDSLPTSGTGRLMVGRGSYDYVGDVIAESYFLLLPASDYSIYDLEDRELFDSVTLVLTPDGYTYGLDEDVYRWMVVERLSADLAYRSDGQLYNISEQKATLGDLFELGRKRVRLSQDRLEEIEITLNADFGESLFEKIREKDEIYYSDSEFQQYLNGLRVRFDSTELSPFLGFDTEGVSMRLYYSNPDELPITQKYFEFSIDGAPHYTRLEQTNVDEAFAALKTLEDEVSSDETGHVGLVVGGLGYAIRVDFPSIRNLLLEGDDYLIASAELRLYPTAKNSEDTPFPERLKAFYVNDYNVTVTEDLTYATLHNDDEFGRDTYYTLDVSTLVENLLEPLVINQYAILITMDDDYLNTSINSLALGDASLQSELILYTISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E428</accession>
    <name>A0A654E428_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP pyrophosphatase, house-cleaning of non-canonical NTPs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11531">
        <property type="entry name" value="NTP-PPase_BsYpjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012359">
        <property type="entry name" value="MazG-related_YpjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42692:SF1">
        <property type="entry name" value="PTHR42692:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029904">
        <property type="entry name" value="UCP029904_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="113" mass="13000" checksum="7467AA968F5D9AF9" modified="2020-04-22" version="1">MSEGEITIREAQEKVDQWIKTTGVRYFGELTNMTILTEEVGELARLMARTYGEQSFKESDKGRDLGDEMADVLWVLICMANQTGVDLTEALQKNFQKKNVRDATRHQENEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E471</accession>
    <name>A0A654E471_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UnbV_ASPIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="514"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120077" checksum="57316027ACE68D78" modified="2020-04-22" version="1">MSIRTFCLLILIVSVVSCKEQAPKSLLEYVPAETSGVSFSNTLTEDEQFNIVDYLYFYNGGGVAVGDINNDGLEDIYFTANQAENKLYLNRGNFEFQDITESAGVSSPGAWKTGVTMADVNADGYLDIYVCRVGKYKGISGQNQLFINNGDLTFTESAASFGLDFKGFSTQAAFFDFDNDQDLDVYLLNHSVHTKRSYGRSTLRLDEDSLAGDLLLRNDGGMFVDVTKSAGIYTSQIGYGLGIGLSDFNFDGYTDIYISNDFHENDYLYLNNQDGTFTESIGSMITHSSRSSMGNDIGDINNDGLPEIITLDMLPEDEKVLKNSAGEESYEIYKLKQTFGYEKQFARNMLQLNNGDGTFSEVGLMTGVAATDWSWAPLFADLDLDGYKDLFISNGIVKRPNDLDYIMFLSANDFKVGNDEISDSALIAQMPDGKVENYLFRNQGGISFENVSASWAKLEKTVSTSSVYADLDNDGDLDLVVNNINDRAQILKNNQQGNNYLKVRLKGSSGNPNGVGTKVRLYAEGNLQYQELFPDRGFQSSTTKELVFGVGKSAKVDSLRVIWPGGGTQVLTAVEVNQTILLDMAQAKGLFEYEEEGQPPVLKEVTEQSQLAFRHFENPFVDFNAQYLIPHVISRDGPAIAVADVNGDGLEDAYICGASGNNGMLYLQNADGTFRKHSAETFRSNPAPEETAALFFDADNDGDQDLYLASGGNEFQPPNPRLNDRLFYNDGAGNFSLQQGALEENFQHGSVVIASDIDHDGDQDLFVGGRVVAGKYGQTPESRILFNIGPGRFRNETAGVAPELEHIGMVTDAVWADLDEDGYEDLIIVGEWMPITVFMNRNGKLEKADIPDLDKTNGWWNTITLTDLNGDGRPDFVLGNLGTNSKLQPSVDQPVRMYVNDFDKNLSLDQIITYSIGDKEYPLANRDELVKQMPLIKKLFILNMDFSGKSIDQIFQPEALSASKRYEAYTFKSIALMNLGGIRFEQKELPAVAQRAPVYAIASLDVNNDGNQDLILGGNMEWATPYFGAYDASQGALLLGNGQGEFSVPKASEAGLKIRGDIRSLAVIQSAKGSKYILVGRNDDVALVFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G9</accession>
    <name>A0A654E4G9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dxr</name>
        <name evidence="11" type="ORF">MARINOS108_120392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="265"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD16838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="388" mass="42972" checksum="C65DD42614ED88A2" modified="2020-04-22" version="1">MGEEQKKRGIAVLGSTGSIGTQTLEVIDRHTDKFEVEVLTAQNNADLLIRQALKYKPNTVVIGNESLYDQVFEALDSADIKVYAGQNALADVVKMESIDIVLTALVGYSGLVPTINAIKAGKDIALANKETLVVAGQLVTRLAMEHRCNILPVDSEHSAIFQCIVGELNNPIEKIILTASGGPFRGQVRDQLLQIKKEQALKHPNWDMGAKITIDSATLMNKGLEVIEAKWLFGVKLDQIEVVVHPQSIIHSMVQFEDGSIKAQLGLPDMRLPIQYALSFPERFKSDFPRFDFINYPELTFEKPDTKTFRNLQLAFDAIDKGGNTPCILNAANEIAVAEFLQDNIGFLEISDVIAACMQKVSYISEPELDDYINTDIETRIIAKELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I6</accession>
    <name>A0A654E4I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025003294" evidence="1">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="328" mass="35990" checksum="F4A6C308F6E7D1BC" modified="2020-04-22" version="1">MKRSIIIALIISASMQLIAQDAAKEYILDYNVPESPAFSILDLNPNEVMRGASAKPVVVNIVNQFASKGSIDNGIAIDFNPYFLLGGQLKGVDEYRNSYVKRLLINTQFSLASLEETDSDNTILAHGIRVTLWDDKDLLTNNGLSQSVDAALQPSPVPPNMTNDQVQILDNAKLAKAYEDLKAEYAKTSGSSFSLGYAGKSVVQSSILDGDSINLTSNQFWGAGSFTITERLDFNVMAVSRMFKDMDNEFKAGASLRYNWDKASFTAEYVFNDNEPNGEKNSLSGILTIKLINQISYLMSFGTTKVETGGEEINKLALKSSLKWNIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y0</accession>
    <name>A0A654E4Y0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA domain-containing membrane protein RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="148"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="32072" checksum="26F4775066DDA4C8" modified="2020-04-22" version="1">MNQQLAHLLQLGLAIFIMSSSGTLGRYIELPPPVTIWMRCIIGAVALFIVLKVGKFDLRIGNRKNFWLLFGSSLLLAGHWVSYFYSLKLSTVAIGMLSLFTYPVITAFLEPVMLKIPFQKSSLALGILAFVGVALLAPELSFENEHTLGIAIGVFSALCYSIRNILMKKRVAQQSGITLMFYQLLFISLFLWPVLFGFEFEPAQLSTDWEALLILGLFTTATGHTLLVLSFKHFTVSTVSVISALTPLLGILLGFLVLNEIPAGRTYIGGSLIFLTVVTESLKSIFQKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E523</accession>
    <name>A0A654E523_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">murI</name>
        <name evidence="8" type="ORF">MARINOS108_20961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="30687" checksum="297107BECCBBE603" modified="2020-04-22" version="1">MEQGPIGIFDSGYGGLTVLREIVKVLPDHDFLYLGDNARTPYGNRSFKTIYEYTLESVKYLLNEGCPLIILACNTASAKALRTIQQRDLPGLAPDRRVLGVIRPTAEVIGQYSQTGHVGVLGTSGTVNSESYLLEIKKQSPELKVFQQACPMWVPLVENGEHDSEGADYFVEKYLRELFSQSEKIDTLLLACTHYPLLIKKIMTRIPAGITVLNQGEIVAPSLEDYLNRHPEISDFCLKNHQLRFLTTDETENFNKKAKTFFGQSILSEFVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E555</accession>
    <name>A0A654E555_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-dehydroquinate synthase</fullName>
            <ecNumber evidence="10">4.2.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroB</name>
        <name evidence="10" type="ORF">MARINOS108_20956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="54"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="344" mass="38437" checksum="787E11582C97D1BD" modified="2020-04-22" version="1">MKIPAYITLTDDPANKLQSLLETFKPDKIAYLVDENTREHCLPLLRVGGDAEIIQIHSGEIFKNLNSCELIWAALTTSGFSRKSMLVNVGGGVIGDMGGFAASTYKRGIRFINIPTTLLAAVDANIGGKLGIDFRGFKNHIGVFNDPDAVVISDLFLKTLPERELRSGFAEVIKHGLIYDKDYFHQISQSSFPNLNWTEVIKRSVEIKSEVVAQDPREAGLRKILNFGHTLGHGIETWYLNSRQSLLHGEAISIGMILEGFLANKLEKLSISDLNEVSNYLISVFGKFDLPPIHEIMPLMLQDKKNVGNEISFSLLDGVGKCSFDELIDLKWIDESFQYYQNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B1</accession>
    <name>A0A654E5B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22701" checksum="23D1378257B6CAC6" modified="2020-04-22" version="1">MIYSSIFSPVVPLIVRILNRKYNLNPSFKVVLILICVSFISDFTSLILVKSGVSNYLIINIYYLCEILLTGTFFYLTLGKKWIVIGVFSSLFVCFIGYAALVGVDQYQHEIIPIFNLFSILFSVLILIEIFKKGEDLFIDTNPLFWFSIGILVYFSGSLFTDVLSKQILSGPLTWAFHNIANILKNLLFAIGLWKVRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B5</accession>
    <name>A0A654E5B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CHASE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_11118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="8">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="323"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="542" mass="61344" checksum="5863AC98A4F19512" modified="2020-04-22" version="1">MLSYEKILGRLVTVPKQMGWAFFILLLCLTQIIAFRIYNMEKAAELHITEREAIFLKGQLEGSLNHSITATKVLAYLVEKDLLSDNFDSICKNLLSQNPFIDALQLVKGDTIINTYPLAGNEATIGYNVGNNSAHREEVEQAKLRGELYFEGPINLIQGGKGIVGRVPISRDGVFWGFSAVIIRHETLIRALNIDPTGMNDQFVYQLIKINTDGKESNPYFQHDQTIDSGIYSEVTVPIGNWIILVKMKQPQYWVNAVTFSLLGILLSALLGVFSWFLAVQPMRLRALVAMKTKDLKTANRTLQKKAKELEFSNSELEQFAYVASHDLQEPLRMITGFLNQLEKKYLNQLDEKALKYIHFAKDGAIRMKHIILDLLEFSRVGILEDALEQVDTRQMVNEVCMLEKRNIEGKNAKINIHNLPVIEFYQVPFLRILRNLVGNALRYNKPDTSPIITISSTTHDDYWEFSVSDNGLGISEEHFDKIFVLFHQVDPGHGGSGMGLAITKKLVENLGGEIWVEAELGVGSTFYFTIPKMRTPTNKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5K9</accession>
    <name>A0A654E5K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="33415" checksum="C6E5E7FD613045A8" modified="2020-04-22" version="1">MITKSKESVTAVIVTLLFVLACSVAVYFFSLKSLAEDELTSEKVKTEKMLSEKLALSKEIEKLKSEIVGYKGKSADLDKRLMSLETQLQQKESELKNQARKGETTIADYKKQLADLQAIRNKLNEEIARQNEQLVALQKENGNLKNTIAMMEETHEDLVTRNTVLSQLISENYGVEAHKKRNKLTVNSKRTKEILLGFDVPTEMTEKLSFKITSPDGKAVASNNSKTITYTVKEDFEFSDSEVMASINGTYASISDKRNKKRVVLTYKPEQKLAGGVYMIDIFSDSTFVGSSQIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5L9</accession>
    <name>A0A654E5L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">aroC</name>
        <name evidence="9" type="ORF">MARINOS108_60077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="299"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="360" mass="38897" checksum="2C08D229DCE535AE" modified="2020-04-22" version="1">MGNIFGKIFSITTFGESHGVAIGVTINGCPAGIPIDMAFIQSELSRRKPGQSKITTQRKEEDEVEILSGVFEGLSTGTPIGLLIRNKDQKSKDYSHIAEKFRPSHADYTYHEKYGVRDYRGGGRSSARETAARVAAGAVAKLMLKEFGISFHAYVSQVGTLKLEKSYEQLDLSKTEDNAVRCPDPEMAQQMFDYIDDVRKSQDTVGGVVTGVIKGVPVGLGEPVFDKLHAELGKAMLSINAVKGFEYGSGFEGIKMKGSAHNDAFYVEDGTVKTKTNLSGGIQGGISNGQDIYFNVAFKPVATIMQDQASIDTQGNEVTVSGKGRHDPCVVPRAVPIVEAMAALVIADFYLIARTNKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5N3</accession>
    <name>A0A654E5N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="404" mass="47602" checksum="4BA6B87CC388A238" modified="2020-04-22" version="1">MSAKEIPFGKILENKIILNGWGAYPDREIGVVREDEETSVKYFEERFTELEAKITALETEIESSENKGSFLMKLIHLKELLGTHDGLGNYQSLLDRLTAQEAYLEETIEKNRVRNTQIKQALIEELRVSVEKINWKEATQEIHDIKARWIKTGNPKEELQEELDTAFWGLIDQFFDKKKEFYEDKKRLGEKRKRDYQNVIAKADQLENLHGKERFDFIQTLKDEWREIGNIQKEDYSPLLRAFNNKLKPGPRPSQSQSFDIHELNKTLQRFTNGEQPYGFKQLEELKTQLKSYRPSDPEGKNLRRNAFQSIQLLLERDFIDKLAHKRFKNFKELEKAKKRQIRIGILEELINRDKADLDKYQENSANFSSSFGGTMDLIEKKLSQQKGKIQVKETLLQLLKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5V4</accession>
    <name>A0A654E5V4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="30119" checksum="BE95A3AD59143D6E" modified="2020-04-22" version="1">MFLHHSVFLCYVKNWFYAILLFHFTSISAQHVISGTVLNESEEPVGFCHVYNQTMGLGKVSDIHGNFKVTAKKGDTLLFSYVGYQSLTLPVNSVHLVNYLKITLPEDSILLPSITIYADPNYRVPLNVHDEPIIIPGVSITEKTDGIQPGDVGFGATGVGGVPVPAVTIYGPITYFSRDEREKRQAVEAYKETRETITYQKFIVQDSVKQKLCELYHLNSQQYDQVIVRLHNQFPGIQKQYNPMEIWNWLLMHFDRSANIVRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6H1</accession>
    <name>A0A654E6H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fdx</name>
        <name evidence="5" type="ORF">MARINOS108_11537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="12684" checksum="3ED7C5F71EC51E2A" modified="2020-04-22" version="1">MAIMITDECINCGACEPECPNTAIYEGGVEWKWSDGTDLKEVEMEDGSVIDGSETQEPVSDEFYYIVSGKCTECTGFHEEPQCAAVCPVDCCVPDPDYEETEEELTAKKEWLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6M6</accession>
    <name>A0A654E6M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="283" mass="32555" checksum="C370D2DAA18794A2" modified="2020-04-22" version="1">MSYEFRDFDESHFIKLHQAFIGAFSEYFVTFQPPLEQFRNRIFNKLHLSPELSMMAWHEDEVVGFMLHTVNDYQGKVTAYNGGTGVIPSHQRSQIATRLYEILLGRMRDQGTISRVLLEVVEQNTKATQFYESLGFQFTRVLRCFSLKGELPDPDPHIKVKKSDQFKSVYQEHISFQPSFLDSTNQLPHNLANEIIIEAWVSETLAGHLVFQPQNGRISQVAVHEDFRQRGVASALMKNALLLSSDPNLTVMNIPEDEHPTIEALKAMGFHNELNQFELELII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E807</accession>
    <name>A0A654E807_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="1">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="167" mass="19003" checksum="BE3B176264918142" modified="2020-04-22" version="1">MHTHRVVIGLLLIGLVGCKTSSVPSSSEEVYKEDLAYLRPSLSEEIAEVPEPETPKLNNTLPTGHLKTELDSVNQIIINNNRAQRYVDGYTIQIYTGNDREAATEAMNKAMSIDPQLDPQIQYYQPSYKVKAGQYINRLEAHEVFERLKVEFPLALLIPERIRVDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E834</accession>
    <name>A0A654E834_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="321" mass="37041" checksum="70C533A1E1C809F2" modified="2020-04-22" version="1">MNRIDRLTAILIQLQGKPRIPMEDFEERFGVSRRTIFRDLKSLMEAGVPIGGDAGEGYFIVDGYHLPPVVFNKEEAAALLLGAKLIEQNADSQIAKNFQEAMYKIKAVLKCHDREFLDTLEQSISVIASPTVTNFGFPDSHIAEIQMALAARKIIQIRYHSNYKDQTTDRKVAPLGLVYYSSRWHLIGYCHLRTDLRDFRTDRIQSLNILSDNYHPEDHPNYLEFLQRMIGGTDANEATIRFSKKVTRFIQDQKYHYGFVEERVEGDVVEMKFITPHYEYLARWLLMFIEEATVVSPPKLQGLVASYSQGLITHHQKYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E851</accession>
    <name>A0A654E851_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="17741" checksum="7D5005AE8173A620" modified="2020-04-22" version="1">MKNVLLIFSVFVILSACSTGDEPGTAERSSTYLLYRANYNPVSGDVTVRELAPGQLQFHIKLQNTTEGGEHPAHLHFGSVREVGELAFALNPVDGSTGESVTVLNGVQMSDGGVLTYDSFLEMDASIKVHMNDNYFKHMVLSFGNVGKNENYFFDGVAMCTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8Q8</accession>
    <name>A0A654E8Q8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="29095" checksum="EF9BF690DAEEE4A3" modified="2020-04-22" version="1">MKKINIYIAILTLGLFAISCNESEDLVTAEAKEAALTTIGSSGGALLGNPTETGEVIFVTAMLDYSVTVSSPNVSDVQSMTVYKSYGTESVEITTASTYPIEVNYSSIGDFMEGFSATAADLAIGDVIGFHTEMTMTDGRVLAQAANRVSLTVQCLSDLAGSYSMTGQRDDGASYSFPVVITELGPGSYVSSRSGSWAKGVLATPTGEAPMLFNDVCGQLYIPMQTLGDFYSNGVWGEGDGAEVTGSVDPSTGVITYSYTIEFSAGNRVYTEVLTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9F7</accession>
    <name>A0A654E9F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="41787" checksum="73905DBF586D494B" modified="2020-04-22" version="1">MIGQRFTEYIPEKNPEQSTFDNLLNVFLQLMVITAGDVAEALSWLTNLDRQYNISNAEYGIGDFIEDLKAKGYITDDNQKGEFKLTAKSEQTIRKSALEEIFGKLRKSGKGDHHTRHSGRGDEISSDFREFQFGDSPEQIELTESLKNAQINHGFGDFMLTEGDLEVREREFKTQTSTVLMIDISHSMILYGEDRITPAKKVAMALAEMITKKYPKDTLDIIVFGNDAWQIEIKDLPYLNVGPYHTNTVAGLELAMDLLRRRKNKNKQIFMITDGKPTCLKEGIKYYQNSFGLDPKILNKTLNLAAQCRRINIPITTFMIASDPYLQQFVREFTEVNSGNAYYSSLQGLGHLIFEDYKKNRRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9H4</accession>
    <name>A0A654E9H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024818489" evidence="2">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="25953" checksum="1ED399A583B54686" modified="2020-04-22" version="1">MSRFFSLLLLMFTLSQCVSPQYACIDLTQKKKKDFRHSRIKKHFVAPDNQQALESPDDLLEEYPFLAKMATDPVILSSENVGFVMPEMGGLEMMAERKRGERRLSGIESRRIEQLKARVAEVIPPDLMDQMSQAQDTSVTRFDDVYNEAKSLAIISFSSSIASILAIALPMFIFPLIIVGLVTGIISLKRYKKAFNKDFKGLAIAGVIISSAWLALILAVLIMVILLFSGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9T0</accession>
    <name>A0A654E9T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein methyltransferase CheR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="34840" checksum="D0EE9CC220F0DE8C" modified="2020-04-22" version="1">MKESVSIFSGEAKPLELITDEEMNALMVAIKNRYGLDFTNYEKASLKRGVNRLMMKHHMDSSLDLWGRILKDHDFFMSAIDDLLVNLTELFRNPDVWIKLRDEILERFKGESLKIWHAGCSTGEEVYTMAIVLEEKGLLGRTKIAASDLSTKALKKAKDGEYSLEVIKPYLTPFLKFFPDRKLEDYFEFHDKHAAIKPHYKRSVTFERHNLVHDPVTGEYDIIFCRNVMIYFDEQLKLKVLNLFYKSLKPNGYLIIGYYDIMPDAGKLLFQVEDIRTRVYRKKEEKGSTQKPKFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9X9</accession>
    <name>A0A654E9X9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="392"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="522"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="650"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="776"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="904"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1415" mass="155716" checksum="D8890A5BD000DE5C" modified="2020-04-22" version="1">MKTKLIFTIVSLLSMLNLRSQSYEQLADSAQQALVDDYSYTVTGGYFFDQSTSPSNTYFHYWWNGYALEVLVDRYERATSGTQRDTAVELMKDLVNGMETANETFNNNYGHYNNFYDDMEWLAISSFRAFEAIKGTHPSDSSLFLDVSTTLLEDIKTGENDIMGGGIAWRKSQRDYKNNAANSPTVIVAARRYQYLGDAEDIALARRLYSWVKSNLVASSGRVYDGVNRDPKNAPGEIDLWEFTYGHGTFIGAALEMYRATDSTHYLDDAILTADYAVGESNNLLNDGIYKSEGASGDAPLFKGVLIRYLTELAMETSVSSIKRDTYKAMVADNASALVSGGLNPVNYHTGPYWGESTCDAVLSAQLAGITLLEMAVKLGLISHDDGFLIPGGINAENYTSATGVSVEENGDADPYCGMNITSFDAPDDISYKVRVTSTDTYLVRVRAASVNSGRQLTISSNGNALATIDIDNTGDAQTYSTVTGMINLTAGVDTLLTLSAPNGSFNLNWIRFENPLVLTSEKIEAENFVEMSGVGTSGTSDFGGGETVDAVGSGDWMEYYVDVKKSRQYNFLVRASRQPVGSDTLQLKSGATLIQEIAIPSTGGWENWATQSTTATLTAGAQILRLESKHGNANINWFKLDSIKSVVSGQIEAEDYQSMSGVVTETTTDTGGGQNVGGIDAGEWMDYELSVESDGWYKLDARIASIYTGRSFQLKKSADVLTTVNIPNTGGWQNFQTETAYVQLTAGVQTLRIHAVDGGFNINWFELTFIPKFVRTIQAEDFISAHAGVGTETNCDIGSGLSLAGIDANEWAEYLVYADSTTDYMFVARVSSELSGKSLTVEVDGTPVETIDVPNTGNWQFYESVSTILNISEGGHTIRISSSTGGFNLNWLKFFRAFSLTDARLEAENAHTEHSEQSGTGCPTFNGSSPYQTEIYGEESEDNLGTRQLSMQTGSWLDYYVYVPTTATYLFSARVSRDNALSGQGVLQLVEDGSTLVTLTIDGTGTWSDFVTLYDQISLSQGPHLLRVNAQTGIFNLNWIRFDKAVVVGDYVKIEAENSNSEAGVFVDQRSDNGIVYTSNDIGVGDHMDYFLDIDNAGQYLFKARVSNSHISNDAEMMIKDANSSTLYDSISISSNTGWHDLDAVIDFPSAGNTVLQLLGNEGEFHMNWFELLYDITDGGGTISDEHDDSPSGEEIDKVIDNSSLTKYLTTHAEGYIEYQTSEGHRVTTYSITSANDAEDRDPKDWKLQGHNGTSWVDLDTQTNQDFSDRYQRRFFYIDNDNSYKRYRLDITANNGSSLLQLAEWQLFGVEESCVSCRESLEDQKVHVEKLSPAEVQIYPNPISAGDQLIVHTYKDDGIREIELIDLSGQQIQRSSYHELPNEVEVSIGRSVKGIYLLKVSTTNGTFVTRVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA61</accession>
    <name>A0A654EA61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="72" mass="8091" checksum="F0318DB31012CFB2" modified="2020-04-22" version="1">MAKRLVRILPEKIADHFQGDQYLSFVSHDATVTLATPLSLKSDTLKVKNTKGHILHLPLAQLDEIWAEVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDW9</accession>
    <name>A0A654EDW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37237" checksum="E5890F84A1EB0E1A" modified="2020-04-22" version="1">MIKKATSVFKYTFSLGLALALLYLAFRNVDFSEFIEKSKQVNYTWVIISILLSLVAYYARAYRWNILLKPLGYPNLNVHKTNLAVLVGYLANLAFPRLGEVTRCGMMKRSDDVPVSTSLGTVITERIIDLLTLIALILLTLVLEYDRLIEFLTHIFSGLQDVEGLMWKAGMIVVVGGASVLIIGYVLYVKNEKIRLFTNNLIRGILSLRDVKNRWGFVLSTIVLWVTYYFMSYIIVFSIPETAHLSWVAGIMLLVTGGIALAVPVQGGIGTYHAFVSAMLVLYSVEKTTGVFLATLLHTSQIVATAIFGGIALLASFFIKKANEPDSTEDRQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDY7</accession>
    <name>A0A654EDY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rimM</name>
        <name evidence="4" type="ORF">MARINOS108_20827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="176" mass="19888" checksum="29453A13537C81D7" modified="2020-04-22" version="1">MGFEECYQLGNVTKTHGLRGEVVLFLDVDNPQEYQELESVFIDLNGKLVPFFMESFHLQGDRAIVAFEEIESIEDASELIGRDLYLPLNRLPKLPKGKYYYHELPGLQVFDGDQLLGQVTQVYQMPNNNLLAVDHQGIEILIPLEEAIVHTVDIAAGKILCTLPDGLLDVYLDQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE06</accession>
    <name>A0A654EE06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="SSF110221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbfB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="464"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="546" mass="59695" checksum="F0DFAB642FAC4BA3" modified="2020-04-22" version="1">MKLKKLQIRIIVIMMIVMGAFGADLHAQTTRFESHNFPGNYIRHAYSRGRIDANVSPFQDSEFRIVPGLANGAAISLESVNFPGSFLRHKNGEIWLEPNDGSGIFHQDATWWMRSGLAGGGVSFESYNFWGNYIRHRNGLLYSESPGGLPADATFHERPVGGGAMVDAFEGADPEITNFDGNYRIYVTNQGGVIRCMRPYDNNNLKGSWYATTAFTMPPHLINGWAPAVVKVGSEYRMYFNAIDTRGPDDNNIYVAFSNNPNSGFANEVEVVHDGAGGCTDVIDAGIDGNIIYYGGSVGGGAFMADLTNNGRSSANHRMVNGLTNYSEAPFVGYVTGVGKVMLYARGFYYNDSYGTNWATGDGQNWTYQGQVNFPNADQYLFRLGHASTVNDYIAVNSNRAGTPVRRIAIGQLSLQGGYLEGNRVSGDPGADTEGMVLTVVIEDLTDVNVVADFGEMKPSDFKIYPNPVQGTEFFIAFNAREVATSAQIDIYDLSGALVLQVIKENVEMGVNSYQLDRSGLRAGQYMLRVTNDRGQLLGGDTFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEY2</accession>
    <name>A0A654EEY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_60033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="454" mass="49956" checksum="D1ED60C3A8339A43" modified="2020-04-22" version="1">MNVINPATEEVISVLTPDTAATVAAKLKALRAGQKDWQNHSVEERLAIIERFGELVMENKPELARILTSETGKPISQSINEINGSLGRIQHLKTNAEKWLESEMITPKDATVEFITHEPLGVIANISAWNFPYNVGYNVFLYALVAGNAVLYKPSEFASLTGLKFKALLHEAGVPANVFEVVIGSGAVGQYLLEADLDGYFFTGSYKTGVHITQTVAHKLVPVQLELGGKDPLYVMDDVVDVRQAAINAAEGAFYNNGQSCCAVERIYVQEDIYEEFVQHFTEEVKSYKLGDPMEEDTFTGPLTRPQQIAVLSDQIKDAVAKGAQLVLGGESLSRKGYFMSPAVLTGVNHTMELMREESFGPIIGIQKVSSDEEATDLMRDTPYGLTAAVFSEDEARARKVLDQMNVGTVYWNCCDRVSPNLPWSGRKNSGLGATLSYMGIRAFTQPKAYHWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT05</accession>
    <name>A0A654DT05_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="137" mass="15170" checksum="08ADD23140610628" modified="2020-04-22" version="1">MKIFRYIIVGIVFGITLAKSEVISWYRIYEMFKFQSFHMYGVIGSAVILGIISVQMMKRFNIKTIDGLPIVINPKQMSVSRYLFGGIIFGLGWAMTGACPGPMFILLGNGVGVILVVIASALLGTYTYGLVRNKLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT20</accession>
    <name>A0A654DT20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="342"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD10683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="497" mass="56432" checksum="38704CF77F6774F9" modified="2020-04-22" version="1">MGVVIRQSFWGSVFAYVGVVIGYLNALYLRPKYLDPEQIGLLNIVVNNALLIAPFICLGMPSTLVKYYPHVEKDEARRRSFLSNQIYLILFANILGALLFFIFTDDIKSVFEKKSAAYNEYIFLSLMILVSQTFFIQLQSYSRVVLDIVVPAILKDIYLRIGYALLICLYAANLIDFGDTVKGLTLVYISATIIEAMHVLINQNFKMSLFSWTSMKKWIAETWNYSIYNLAASAGNSIYTNISFLLITTLIGLESNGIFTTCFYIGIIIELPNRAVLMITAPVVSREFKNKNYVEIENLYQRSSLTLGCIGFLFLIGIVCNIEDLFLMIPNGKVFSQGLYVVMAISFAKVFDMLFGLNGNILAYSEHYRVNVYFLLLSVAVLCILNLTLLPTIGINGAGIAFLVSTILFNLLKHYYIVRHLKISLFTKNHIWLLLIGFGTMLLFYFVSIWESPVLNIVGKSALISTFYGILIYKFNISRDINSFVKSIFKKYLNIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT34</accession>
    <name>A0A654DT34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="31913" checksum="7DDD6D3580A512E8" modified="2020-04-22" version="1">MNRTIITFLTLAILSCKTKETTEIIVIGTLHQPEANFNSEILFKILEEVKPDFILLELDSNKFTADFRLKEAKENELLASKKYQEYYPDTQLRPYEFEDRNQYRIDKGMRPTDGLTLRLVDSLYHVGLLTTAETEIFKTYKETLEPLKILAAKSPENFNNPTTDSLCERRQYYQYEMIPKITNVRDEFDSRFLIKPNGERISYRDGYQLWADFWDLRNQTMAKNIMVISEQSEGKKIVVLCGFMHRYYILSELKQLTHGTDITLNEYYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTK4</accession>
    <name>A0A654DTK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="137"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="402" mass="45038" checksum="1415973021752C71" modified="2020-04-22" version="1">MFSTHALTESFLTAKRHETDPLADQVVATIIDEGFEERINEIFYTLARNDSYTPELLSHFPENIQKVVGDYFTQSAKLPSWANDQLISKGQDVFGMYGPEVFMLLNVKSLPMCYTCANGAQVLFDTGRLIEKKGNIDPLVRRLMETAQMVVNVLQPGGLTPGGKGIVTVQKVRLIHASIRHFIKSEKYNPKGWDTSRLGEPINQEDLAGTLMSFSPIILSGLKSLNINLTDEQIASYTHCWKVIGHMMGLNDDLLADTFEDNWILACKILSHQSEASPQGKALADSCMAFIQHMIPGTLFDDVPAYMIWYFFQDVEKAVGKPLSSMIGIPDHADLKDHLVMRISQIITGGISKAEHSPIISKLTESFNKLLLQGYLKHYNEGKNVRFFIPPSLQENWGVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTL4</accession>
    <name>A0A654DTL4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ORF">MARINOS108_10045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD10422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="36057" checksum="615AD86A45A005D6" modified="2020-04-22" version="1">MKVTEHIKASTESTLFSLEIIPPKKGDSIDSLFAHIDPLMEFKPPFIDVTYHREEFVYKNRENGLLEKKTIRKRPGTVGICAAIKNRYNVDPVPHIICGGFTKEETENALIDLNFLGIDNVLVLRGDSIAEEKTFRPEPDGNAYAIDLVDQVMGMNEARYLDEELQNAVPTSFCIGVAGYPEKHFEAPNLRSDLKYLKQKVDRGAEYIVTQMFFENSKYFEFVDKCRAAGINVPIIPGLKPITTKSHMTALPSIFHIDIPDDLYNEIEKCKDNKAVKEVGIEWGIQQSKELMEKGVPVLHYYSMGKSDSVYRIAKALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTQ1</accession>
    <name>A0A654DTQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="13606" checksum="B0C2D52CA64FA2F2" modified="2020-04-22" version="1">MNNEPTKISSELLELLVNREFGERSIEVSEQLKQVKSDSESGRRRISAAILKLANRSQERLEQLIQRANTDFRDIVAEAEYPRVLEAGFGELSDEQEQQANEEDWNEYRNWLHGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTS3</accession>
    <name>A0A654DTS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="281" mass="30870" checksum="78F4EC1822FB4DE8" modified="2020-04-22" version="1">MKIIECPRDAMQGLTDFVPTALKIKYINQLLRVGFDTIDFGSFVSPKAIPQMKDTAEVLQGLHLSESSSKLLAIVANVRGAEQVADYEEIQYLGYPLSLSETFQQRNTNRSIDDAFDNLAEIQEICQMDGKTLVVYLSMGFGNPYGDPYEMDFVGQFVDQLDEMEVGIISLADTVGVSTPEGISTLYQTLIPKFPHIEFGAHLHSNPATAREKIVAAYESGCRRIDGALRGFGGCPMAKDDLVGNMATENILKVLSELSAEIAINDEAMAESLLISNEVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTT5</accession>
    <name>A0A654DTT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="138" mass="15392" checksum="F69674A3FB6AB9A0" modified="2020-04-22" version="1">MSRFRFLLAGVFFGIVLTKAEVISWYRIYEMFRFESFHMYGVIGSAVVLGIIAVQIIKRFNIKDISGNPIVIQEKAKRFWPPLIGGTIFGFGWALTGACPGPIYILIGNGFMAFGVVFLAAVLGTFVYGLVMDKLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTV8</accession>
    <name>A0A654DTV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="114" mass="13400" checksum="2D17DC808DB586E9" modified="2020-04-22" version="1">MENPFQELYERLDRIERLLVSVRDHKASEPEGEEDRLLNVREAARFLGDAVATLYGRTSKNDIPFYKRGKIMFLPLISSRIHSLFRNSSEQFVNMIVVKLAMLIRFFLVRPNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU33</accession>
    <name>A0A654DU33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histidine kinase</fullName>
            <ecNumber evidence="15">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MARINOS108_10154</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="15"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="399"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="454"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="525"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="594"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="841"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="991"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="7">
        <location>
            <position position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1087" mass="125544" checksum="D57401808DD2CA7F" modified="2020-04-22" version="1">MDLAEQDIKSLKEEVKSLQERLEKAHEDYYGLVEKTNFHLKELFDSSNDLIQIFKPNGEFRFVNEAWRNKLGYREDEIFDLKFVEVVHPDHRKQTLHNLLKITAGSRLERFETVLKTKYGKNIYVIGKLTCVFENDEPAEFRCVFFDITERFRAERAQSLYYKIANITISQNSPEDFYGKIFQELNDILKVRNFSVALKQGKTYQYAYWVNGDEEKTGVKFKKDVEKLLADYTFERGKPMIIYSDGIEKIAKQKKVKLQDKLPNIWLGVLIQLDSRPIGVLSVFSYQDQSAYNHKDLELLDFISGQITLSMERKLNTEKIQNQGARINAIFESSTHQIWSLDSELRFTSFNQNYAEAFEAYYGHEPKIGMSLKDQDPHTMSHKASDFWQKKYEHVFKGNTLNFQTSQKTLDGQKVWRDVFLNPIFLPDGSIHEISAIANDITEKKLSETALMESEEKFRNIFESFQDIYFRCNMDGIISLVSPSVKRVLGFYQEEVVGKKITDYFISKSKLSDLFKELYKDKQVQNYEGVVVTKEGNEIQFLSNVRLIKRRKNKYEIEGVARDFTRLKETNRQLREAKELAERSLQIKERFLANMSHEIRTPMNGIIGMIDLIGSTQLDKEQSEYIRTIKKSSDSLLHILNDILDLSKIEAGKMKLRLQPVRLIDTFEKVYELYSQQAHLSNNTLYYHLDDQLPEYIMADETRLTQVLSNLTSNAIKFSPKKGNINLSIRVLNRQDNCYRFKVFIKDSGIGIYQNDIEKLFQNFSQIDSSSSKNYSGTGLGLAISKELVKSMGGEIGVASTPGLGSTFWFTFEAYSISADEISEKTEESVFVKQFTDSSPRILLVDDNQINRNVAKSILLKSGCEVVEVSSGQEAIKEVKKKKFDLIFMDIQMPDMDGVQATAKIKKLKLDHRPPIVAMTAYSMEEDRVKFLKKGLDDYIAKPIKANSLIEKVKTWLHFEPKSVSSEVFNESAEELVINQNTLNHLYKYGGRELIESVLSDFDEEATAQVASVTDFAGKKEYESMRRELHTLKGNAGTLGIERLAAVAKEMEKKLKSKDYKYMNKQLGELKKCLTEFKESYANFLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUD9</accession>
    <name>A0A654DUD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="350"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="494" mass="55301" checksum="2CD44A16C7089D7E" modified="2020-04-22" version="1">MKKYDVVIIGAGPAGYAAAMRAVDFKKKVALIEKKQLGGAGIHHGALWSKTWWELSREAFSLRKHGEALNTGGVQFNYKKLKSEVQKAVQERMDQLEHHMHNINVSIEEGLFEYIQGNAKVKDPNTIEIQRFEETTQISADYIIVATGSRPRLLPEIPIDEECIFTSDGLDKLEDFPKSMVIVGAGVIGCEFATIFSNFGHTKVHLIDKGDRILPFEDEDVVKVIEKNLEAKNVLIHRNSRLIDMRKEGEMVAYTLEYTDGSKEVFRVEKALVSVGRVPRYENLFESNMDIKIDGRGIIDDLTQTSIPNIYAVGDITADISLVNVGELEGRFAIERIFGKPERPLIYENISTIMFLSPEVAGVGMNEIQAQNSELGYKVVSIDYSCIPRAIAMRNTQGFIKIMVTDDEHQKILGMRVVGEHASSAIQAVALLISMDRGIRELAELIHPHPSIIEGIQECGRMLLGKSMLKPAVLRHAMVCKTYEKGKYKDLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUF1</accession>
    <name>A0A654DUF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5777 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045916">
        <property type="entry name" value="DUF5777"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19089">
        <property type="entry name" value="DUF5777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024827357" description="DUF5777 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5777" evidence="2">
        <location>
            <begin position="43"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="32390" checksum="FBBBB8320A94A71F" modified="2020-04-22" version="1">MLKHCLSTSIALIFSLTLAAQDDLLSMLEDERGDQKTLTEATFKGTRLINGHSIETRKKGVMDFIIAHRFGTIDGGGYELFGLDNATIRIGLEYALNDRLYLGLGRSSFEKTYDSFIKYRIVRQSTGEGSIPFSATWLSSIALKTLKDPEYDLSLANRLANTHSLLLARKLNSSISLQLVPTWVHRNLIRVEDINNDIFALGMGGRVKFSQRLALCVEYYHQFQQLNENTRNSLAIGIDLETGGHVFQLQFTNATSMVPKGFISETTNNFFDGEIHFGFNISRTFQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ0</accession>
    <name>A0A654DUJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="23608" checksum="5E2B28C8EB96F2CA" modified="2020-04-22" version="1">MSDNLIWVQERMTQYKGMVNAYVIFAHAAPGIKREKKVIGDSLFYLPFRDLIQTFSEPILYIQGNKHVWNYDTTYFGELQLDNFLRVVIDEDKLTQSVLQVVVSWDRNHPFYFDRNMMSDSLSADPSLTVLDSSSVTISWQTNQPTSSVVRYGKLNGSLQYRKEDLTEKTNHQITITNLDKATNYQFEVGTRTSRLSEKLTLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ5</accession>
    <name>A0A654DUJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024839765" evidence="2">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="388" mass="42567" checksum="0B69137ADA0B2FCF" modified="2020-04-22" version="1">MKNSFSALIIFLFVNQAFGQWTSTGDNATQGSIKVKNYLLFDADGDFSGANYFTIQDDASGDFLRIGRGFDHNLVITSNGYIGIGKTNPTEPLHILDVSGSFTFGRPGSEMNNRFTIDAASGYENQIYFRSRPGRIFTSSGQNLTLGNSSTANNLVISGSTGNIGIGTISPDFKLDVNGSLRLGIDDNSGMSISRFTSALTDVPGSTGGILFKGPVHSHIVFDVQGNDPHDGFYIRVPDVLQVNPTVNTTAFVVKANGNVGIGTDPSEKLTVDGKIRSEEIKVEIVNGPDYVFESDYELRTLKDTKEYIIANKHLPEIPSAKEMETEGVDLGDMNMKLLRKIEELTLYQIELLEKLEQQSARMAELETSNIRINELEKKMLELMSTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL4</accession>
    <name>A0A654DUL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="2">
        <location>
            <begin position="423"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="492" mass="55633" checksum="046DA9971738B916" modified="2020-04-22" version="1">MIKKRYLIYLSALFYFFIFNLHGQDIKVMSYNMQQPYGTNWDRRVDNAASIINTHQPDILGTQELHGYMRDQILGRTSGYSTYGISRECDGSGESSYIFYKTNKYDVDYANSGTFWLKDDYWNCGRGYDPDYNRVVTYVRFRDKATGNHFYVYNSHFPMVSYHGARVQSAELLCQRAINRAIKDPVIFTGDFNSTEGEINPIEYIKNGSSLKMRDTYREVYPTGSVTTGFGTRLDYIFIENQSSNSTLSTYVVNSPVASDHLPIVATVRIGGHSNLPIGQTIWLQNGNKYVSSNDGGSPITCDRPSVQDWEKFLVVDAGGGRVALKGSNGKYVSCENGYSAMTCNRVSYDDWEKFEWVAVSSDEVALFGFNNKYVSSENGSTSGMNCNRHAYQGWEVFRWGTANSSARVGDEVVELSVENSFYPNPCVDKLTFANSEPNVSLSIYSLSGHLLLDRTYKEGKHDIDVSDFKEGIYVAKVQKEGQTQTVKLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM3</accession>
    <name>A0A654DUM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="166" mass="18761" checksum="550356E1D1E7D80B" modified="2020-04-22" version="1">MNKMRQKRLNISLINTTLLLALIVGFSACKNKKKVAEVSDPQEVRDQIEEELAEDQTEEMEEPEERIATKEPNKSQKLENYFTAIANAPSATSANGSISEALTMFGRPDAPVLIVIYRKDGSTDYDEPTTIKKYLEYLKDTGNNKAKVEEMVLDDYGKIKELVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN3</accession>
    <name>A0A654DUN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YceI-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024878536" evidence="1">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="19994" checksum="CA34A092BC6838A7" modified="2020-04-22" version="1">MLKIGILSLVMALCAIAQISAQGPILDRKGTASFFSEAPLENIEAINKEVLGAIDLNKGTLAVSMLIKGFHFDKSLMEEHFNENYLESEKFPKATFKGQIKNFADLDFSNSGSFEAEVSGEIEIHGVKKPLTTVVKFARTAATLTAATNFELSVAEFDIEIPSLVFQNIAEVVEVKALFNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUU0</accession>
    <name>A0A654DUU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024986150" evidence="2">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="23345" checksum="65EEA69AAD47759F" modified="2020-04-22" version="1">MKKVRRALKLCLLLFTVMATTHVGYTQESLKDQYEQIMQKSSTYEQYKVIRQTEIEGFWVNIADTLSSKSDEISSLQSRITGLQTNIDSLKSDLRKVNVRLAESIKTNDVITFLGMEMEKTAYHILVWVIILILAVAVVLAYGMFMKSNASTSRIKREFEQQRKEFETHRDKSRETQVRLKRELQTAVNTIEEMKRGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV5</accession>
    <name>A0A654DUV5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="19202" checksum="CC5253138E298D39" modified="2020-04-22" version="1">MSLDGYITSPDDDSSQLHSWYFGGDTPLPGTPFKVSKASAELIGKAMASVGTMVTGRRTFDVSQAWGGHPPLGVHHFVVTHQPVAEWTKADSPFTFITTGVEDAISQARASAGSKAVCISSASILQQALKAGLVDEIHIDLVHVLLGNGKPLFANTSQPKLECFRSVNGTGVTHLAFNVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY0</accession>
    <name>A0A654DUY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1153" mass="130335" checksum="E34FC99E2B0620CB" modified="2020-04-22" version="1">MNRSRGKVLPSTSHYLSIRYSLILLFGLIVLTAHSQSFKCSTYLVGETVLLDTLPVEASSVSINPDVAFRLEPDHRTITFLETLPQDSVEICFRSVSEVIHRPVFNRDVNRYTAGALRERGTALSPIKEEEIFSFGTVSTFGAITRGVTFGNRQNVFVNSALNLQMEGNLSEDLKVSAVITDQNIPYQPEGNTQQIRDFDNVFIKLYNDQFEVIAGDIVLQNPVKESYFLKYYKNVQGLAMKAHTSVGKDWKSTSQVSGALAKGQFTSAVIQPQEGVQGPYKLRGANGERFIIVMANSERVYLDGRLLERGFDRDYVIDYNLGEITFSSAVIITRFSRIRVDYEFANQFYTRTNLSATQQLSNEHLSVYFNYYQEKDNPSNTLAFDLNESDVLNLRAAGDNGGVASISGVDSTAYIENAVLYQKRDTVNAEGAQISIFQQSTDPEVAVFRISFSEVGTGNGDYMLANTTSNGRIYEWVGTGAGSYAPIQVIPTPNQKRMFVSGLRAKIGAYEQVYQELAISTLDQNLYSPIDDADNSGFAWKGGVVSSGREISFLAGYPVNAELTYEFDSRYFTFIDRFRSADYDRDWGYDVFADTLKTRQDQIFSAQVGLRKDDRNGGQYGLTVRNRAQVVAGVQQELNLGHRIGPMEVKSSNFLMTNQPTGYHSEWLRSSQQIQLVDWVLRPGYHFSLDHNTTTDVDTEEVLSTLMYFDAHDFFVESGDSLKTTFRADYILRKDKLPVDGTLSPYTEAEEYRFTMNSKSLTNHQVGAQLNYRKVKEQIGDRDTDENILGRVSWLGHFAKRHITSNLTFATANIRELKREFVFLNVATGEGTHTWRDENEDGIQDINEFYEAINPDEKTFIKLFTPTDEYINAYQSTYIHTLDVKMPEGWRDESGILPVLSRVSFNTNLKYDFKTTSQDLMSRLDPFSVDLSDEKVVSARNLYRHTLFYNRNAPGFGLDVTRSGQSSKSLLSGGFEIREKQDWLAAYRIGFGSVVTLRGRGGLGETVNHSDFLESRNFSLGRRTIESEVVWQPLNTFRLITGYGRRDKQRLAEGDENTQINEYKLEATWVRSGQGNLNASFTWLEIQFEGEINSYLGYELLEALQPGTNQKWNINWQQSLGKGLQLSLQYFGRKSAESAAVHTGSVQVTAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ5</accession>
    <name>A0A654DUZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="43854" checksum="252C700D881080AE" modified="2020-04-22" version="1">MMEKGFDDLLAKKMRGAFLDLEAPYDEGAWERFLERKKSKKRVIFWLGASVAASIVLAICFDPLYQLTIFPKPIAPIIQNEKIIPPASQLQPREELIDVKDEQWVSNSLRLAYEKVPSRKANIHRQTIAFETESDNLHKTTSETDHADIHSIPDSLKQTDSNLADLFADSTYLALENDKEGNKQLLFGVILASGIGVDNSSQGLTGAMSYNGGVSFELPIADQLSIGTGLVVNYMSTDRESTSFVGDLNNPDKREDAFHSEYFNLGIPIQLVYTLNERKDNLFALIGINSYYSVKQQTHVNSTTTRDVHVFSGDGEPMIVTETFGSSETIRGEGNELLPAATLDLALSYRLFQSEGLVYEIRPFYRHPISSITGDGTRVPMGGVAIRLLFKQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV32</accession>
    <name>A0A654DV32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="117" mass="13548" checksum="03DA02698640FC3C" modified="2020-04-22" version="1">MKYFFPLLLTLSLSACYSIPEIEGFDKDVWQSEMSCDTNRLAMVQLLISQQEKLLGEGQAEIQQLLGAPDEHELYNRNQKFFYYNLTPPTGCENGTFRRLSVKFDALDRVKEVMVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV67</accession>
    <name>A0A654DV67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018673">
        <property type="entry name" value="DUF2141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09912">
        <property type="entry name" value="DUF2141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="139" mass="15380" checksum="82CD24892E2084E6" modified="2020-04-22" version="1">MKTILLLLALSYMYPSVGQSPVNFTVYVKQFAHQEGKLRVALFNSEGKYLKEACREMGAEIDNLEVVSVTFEGLPSGEYAISIYHDENGNGQLDANFMGIPTEDYAFSNNAPSRFGPASYSDARIEVSTNNNTHTINLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVD8</accession>
    <name>A0A654DVD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="28053" checksum="B314ABEFA22CA9FF" modified="2020-04-22" version="1">MGNLNHDWLTEGMIDYEYKKYVLLAYLKDIKQHFDSAELFPFLSDLIMHYKNLLNVKSNKELIYEHFPKSISRADFKKLKFTYHRMIQDDEMMQEIEDIIGFALPKLEGSINEGKELYDLVEDNLEVSAVGLTPIYAKEGYVLVNQDAKRDVSVFRYQVSVFENADEKYRGISTTFLTNDFRDISRTYEQIKMDLVRRFRELPNPATFLVVSKLKFPLPQTILPVAKRMLVRKIEEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVN2</accession>
    <name>A0A654DVN2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">MARINOS108_11050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="478"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="548" mass="57971" checksum="AE068B25F6BFA717" modified="2020-04-22" version="1">MAKDIFFNTEARDSIKRGVDILADAVKVTLGPKGRNVILDKKFGAPTVTKDGVSVAKEIELKNPIENMGAQLVKEVASKTADDAGDGTTTATVLTQAIFGHGIKNVAAGANPMDLKRGIDKAVAKVIENLRAQSKDISTSEEISQVASVSANNDAEIGKMIADAMEKVGKDGVITVEEAKGTETEVKTVEGMQFDRGYLSPYFVTNTEKMEAELENPYILIYDKKVSSMKELLPILEATAQTGRPLLIIAEDVEGEALATLVVNKIRGSLKIAAVKAPGFGDRRKAMLEDIAVLTGGTLISEERGYKLENATLDYLGTAEKISIDKDNTIIVNGAGKTEDIAARVNQIKSQIENTTSDYDKEKLQERLAKLSGGVAILYIGAATEVEMKEKKDRVDDALHATRAAVQEGIVAGGGVALIRALKAIEGLELENIDQTTGVKIIYNAIQAPLRTIVNNAGGEASVVVNAVKEGKDDYGFNAATGEYVNMFKAGIIDPTKVTRLALENAASIAALLLTTECVVADHPEEEAAGGGMPGGMPGGMGGMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY9</accession>
    <name>A0A654DVY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Immunity protein 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028952">
        <property type="entry name" value="Imm63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15599">
        <property type="entry name" value="Imm63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Imm63" evidence="1">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14714" checksum="5B36E4D261E2B61D" modified="2020-04-22" version="1">MTIEEVQNEMRRMAQLIGAKSDQLPTVCRLQGGGRPNINISDDGLLSYEAYERGLQVFCYTFTDLEELMYHTFQHVVPAMASAHAMEMDPSGQDFHKHFLIKKIELMSRIKPEWGQRVEDEYNQAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW19</accession>
    <name>A0A654DW19_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ORF">MARINOS108_11173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="311" mass="35258" checksum="C5408DA5739227E9" modified="2020-04-22" version="1">MKLIDDLSQFTAPAYSVVTSGTFDGVHVGHQKILQKIVQEARKRGGKSIVLTFWPHPRFVLKKDAGDLKLLTTFEEKVELLAQNGIDYLVKIPFTKEFSELTSDQFIRQVLVEKLNTKLLVIGYDHRFGKNREGGFDYLMEHSGEYGFAIKEISRKDIEDVGVSSTLIRNSLAEGNIHIANDFLGRPYSLSGFVKDGDRIGRSIGFPTANIDVPEAYKLIPADGAYAVLVSLEGQKFQGMLNIGQRPTVSGEERRIEVNLFNFDADIYNQRLTIEFIKLLRTERKFESIERLKEQLSLDKLEAIRILNQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW63</accession>
    <name>A0A654DW63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="8358" checksum="663E1AE9F8F4336A" modified="2020-04-22" version="1">MSEKQNQSEEKNDAGYYFNFKEVLTYFFRKKDPSRPTNTSIKMMHGINKISMIMFLICVIVIIVRYIIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL2</accession>
    <name>A0A654DWL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112953" checksum="6CE9CA197BF38155" modified="2020-04-22" version="1">MASISNISIERPVLAIVMSVIIILFGVIGFNFLGVREYPSVDPPVITVSTSYTGASADVIETQITEPLEESINGIDGIKTLSSISADGRSTITVEFNLEVDLEAAANDVRDKVSRAIRNLPPDADPPIVTKADADSSPIIALRIFSEKRNLLEMTEIADNIFKETFQTIPGVSEVRIWGEKKYSIRLWMDPDKLAAYRLTPLDILNSVGDQNIELPSGRIEGSATELTVRTFGRLSSPEEFNDLILKESDNDIVRFRDIGRAEFFPENERTALRNNGIPLVLNAIVPQPGSNNLEIAAEFYKRLEGLQKNLPEDISTEIAFDNTQYIKESIAEVQQTIFVAFGLVVLIIFAFLRDWRTTFIPVITVPIALIGSFFTMYALDFSINVLTLLGIVLAIGLVVDDAIVVLENIYSKIEDGMEPEEAGKKGTKEIFFAVISTTVALTSVFFPIVFLQGLTGRLFREFGITVAVAVVISSFVALTLTPMLSSKMLKKRERKQWFYRKTEPFFIWMNNGYNNALDSFMDNRWLSGLIIIISGVLIYIFALTLPSELSPLEDRGQFRIFATGPEGATFEYMDAYATEMTSVLSEKVPEAKSIITITSPGFTSSGSVNSAFIIMKLEDAKNRKRTQHEIVMDVQPEVAKNTKARAFINEPESIGRSFGGMPVSFVIQARNLDQLKEVLPAFLAKASANPHFSFVDLNLKFNKPEIGVRIDREKAQTMGVSVKDIAQTLQLSLSGNRFGYFIMNGKQYYVIGQLEKSNRNEPLDLRSIYVKASNGELVQLDNLVTLEERSTPPQLFHYNRFTSATVSAKLAEGVSLGEGLKEMDLIAEEVLDDRFQTALSGTSLEFQQSASNLYFAFALALILIYLVLAAQFESFRDPLIIMFTVPLALSGALLSLWYFNESLNIFSQIGMIMLIGLITKNGILIVEFANQRKAQDYSIMESIKGAAKMRFRPILMTSLSTILGILPIALALGAGAESRVSMGIAVIGGMIIATFLSLFVIPAIYSFLTSKQKRLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN7</accession>
    <name>A0A654DWN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="7844" checksum="179CDE63367403BF" modified="2020-04-22" version="1">METFKLQEGEEYIELNNLMKILNWVASGGEAKSQIDEGLVTVNGEVETRRRKKLRSGDKVEYGSEAAIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX60</accession>
    <name>A0A654DX60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024893981" evidence="1">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="148" mass="16187" checksum="98771EDDAC3890AF" modified="2020-04-22" version="1">MYVNFTQKKNYMRVLASLFILCVGFGVVAQTTGAEEVQNGPRITFTESAHNFGDITQGDRVTHVFKYENTGNEPLILSDVRTTCGCTATNWDREPLAPGATAEITVNFNSRGKMGMQNKVVTILSNAINSTERVKITTNVLAPAPVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX95</accession>
    <name>A0A654DX95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="380" mass="41347" checksum="5D5D632F9454F572" modified="2020-04-22" version="1">MRGQSIKLIAPVLLSYIVMGFVDIVGVSTGYAQRDFSLTPDMAQLIPSMVFVWFFVLSIPVGVLQSRLGKKRILITGVFLTSLGMFVPFIHYSYPTLLLSFLFLGVGNTVIQVASNPLLKDAVPESKFSSFMSLSQFIKAISSLIGPLIVTIMVTRFGDWKHVFLVYGAVSIISGTWLIMVNIEEAQTTQKASFSSSLKLLRNPLVLSMVVSIFLIVGLDVGMNTNIQNLLVQKFGLTLEKASLGISVYFFALMVSRFFGAILLAKVKNFSFLVWSALLSCLFIILLMVSPSSSLAIVSIALIGLVSGNLFPLVFSLTINKLPERSNEISALMIMAVVGGAVIPPVMGLVNKMLGASLSFVVLLICALYVFGSSFILKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXB3</accession>
    <name>A0A654DXB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane family 220 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029377">
        <property type="entry name" value="TMEM220"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15071">
        <property type="entry name" value="TMEM220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="14142" checksum="A0006AC458FF3A28" modified="2020-04-22" version="1">MSTKNIHYLIAVIFIAFAALQYNDPDPLLWMLIYGVVTLVAVLKVYLRQLNFKPLVTTFMVIFGLYSLMYVPVFVEFLGNPDKSELFGAMKVTKSWIEGTREFLGLLIAIGALEYLRRSKVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXP1</accession>
    <name>A0A654DXP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="82" mass="9260" checksum="4B7E65F923006BD9" modified="2020-04-22" version="1">MSSKLRYLLPSLSGQNLESSNSYICNMVTVIKKGSPIQEQLKKLNEVVSKEHKGISTSKYSGILKGKIDPVKYQSDLRDDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR1</accession>
    <name>A0A654DXR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="25195" checksum="8D664C3D8AE07C5A" modified="2020-04-22" version="1">MGQKKKKQHFVPKLYLRNFTNSSGKIFAFDLQENKSFPTTVDNIAHDRYFYDFEPIDSYVGEQVIENSLADFEGDAAELLDKMLQRLDNGSLEGHTPEERILLAEYISIQMHRTPESRKKYEHFGIELERQLKAKGVSGEFIKQRGLSQESIDPKTLQLYGLTSMMSSKKRILSLCDRIWVYWENLTQHEFYASDHPVVGYTYRDVSETAYEIFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS5</accession>
    <name>A0A654DXS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="57" mass="6582" checksum="A15C3E2F7566D120" modified="2020-04-22" version="1">MLDGLVSIRPLTQEELRKNLIDVFSVRYSRKFNSISIDENTNSIISRTNTKCVFKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS8</accession>
    <name>A0A654DXS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045670">
        <property type="entry name" value="DUF5916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19313">
        <property type="entry name" value="DUF5916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024898124" evidence="1">
        <location>
            <begin position="20"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="2">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5916" evidence="3">
        <location>
            <begin position="229"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="873" mass="99410" checksum="08929A9C3FA58130" modified="2020-04-22" version="1">MKSVGLVCILALLCFESYAQPKTYETTMVQAPPVIDGKLDDPAWDLVDWGGDFIQRQPEDGAAPSQDTKFKILYDAKYLYIGIRAFDLEPDKVARRMSRRDGFEGDLVEVNIDSYNDKRTAFSFTASASGVKGEEYVSNNGDDWDSTWDPIWYLKTSLDDQGWIAEFKIPLSQLRFADKEEHVWGIQVMRMVFRKQERSYWQPIAQDSPGWVHLFGELRGITGIRPQKQLEIQPYILGKTEKSPSVEGNPYATGSESDLDVGVDAKIGLTSDITLDLTINPDFGQVEADPSRVNLSAFQLFFQERRPFFLEGKNTLNFGLTESVAGGQFNNDNLFYSRRIGGSPSYFPSDDDIQYVDRMKKTRILGAAKVTGKNKNGFSWGLLESVTNKEMVEVQDTLGGRRKVAVEPMTNYVVGRVQQDINQGNALIGAMFTATNRRLDEDHFNYLHKSAYTGGVDFTQNFNERNYYLSLNAVVSNVNGDEEAIYNTQTSSERYFQRPDNRRKGVDSTRTSLSGTSGTAAFGKRNGNLIFQTGATMRSPGVELNDVGFLMQSDYISQWTWAQYRILKPFSIFRWVRFNANQYLTWDFGGINLLKAMNFNTHAQFKNMWYVGGGTTLSGESRSNADLRGGPALRYPGTTEYWVYMGTNDQKKLYFEMNPWISSGQENYYRGGGIFTSLRYQPTDALRLSVSPSVDWNDNALQYVSSYETNTENYILARIQQVTYSASVRANYIITPNLSVEYWGQPFISRGEYSDFKKVLSPNSDHFEERHVSLGPDQINYADESGSYFIDENRDGITEAELDDPNFNFMQFRSNFVIRWEYIPGSTLFVVWTSSSSDSHNSRENRFSYLATDLKQADGTNIFLIKYTYRFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV8</accession>
    <name>A0A654DXV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4870" checksum="388F56E8EB8F4BD3" modified="2020-04-22" version="1">MPGPHHYSGTKHNTLQLWKNSPTFGTELPIRTIYFNPIVDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXX9</accession>
    <name>A0A654DXX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="516"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="641" mass="74571" checksum="A689918FC0A0A43A" modified="2020-04-22" version="1">MFFQSFELTIQPQPQPQMRPTHLLQVFLISLVFLLFTFRADAQTDKKYQLQVISQPANTPANAELYAAGNFNNWIAGDRMYQLHPNSEGVYTLQISTPLDTLMYKYTRGTWPSVEGDDFGQIKKNRQLLHTGNAITSVEDEIKTWEDLESSDTYTFVIESLPENTPIDATIYLTGNFNRWEPGNPDYKFSKLEDNTYTYTLKGAPDHLEYKFTRGTWETVEGGSDGRAIGNRQYRRTEGGPVMLYATIKTWEDFSGSKVNYYDFILIIASVIAFLLLVAFNWMVNANVQANRFLSLALALFIIASAARILMNYRQMFHWEPRLVLLPDMVYFTIAPLLYFYFQSLLAVRPRISMSKWISFIPAGILMLTYIPLFVLDRETFIDKMVNREFHWLFALTAGIGLIYNFIYWLRSLRVLKIYTEKMDNTQSFDQSHYYLNSLLTLYSICLFTWLATYLIGGAGLFGEMDTIRITDTTSDLTWILFAGTPFLVAYFALSQPELFRISETSEKYRFSSLSDESVNNLKEQLHQLMLNEKPFLNPKLTLLELAEMIETNTHALSRVINEGFDRNFYDFVNFYRVEEFKRLVNQADHKNLTFLAIAYEVGFSSKTTFNRAFKKLEGHTPREYHKQMIHEGTTEEMKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY00</accession>
    <name>A0A654DY00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntP family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="444" mass="46279" checksum="F34C24C4A73BDA24" modified="2020-04-22" version="1">MLTIVLIILSILLIVISTSRFSLHPFLALLVACLFFGFCSGMAPETIIQTINIGFGETIGKIGIIIISGVIIGAFLEQSGGAYALASQVLRVVGQKRVHLAMGVIGYIVSIPVFADSGFIILSSLNRALAKEAGVSLAGTAIALSLGLTAAHTMVPPTPGPITAAGLVGADLGIVILIGLYTSIGALVVAIFFSKAYAGKVYIDPQPEQTREKIQQKISEAPSSIKSFLPILVPILLIVLRSIADYPTEPFGTGILVDFIFFLGNPVTALFIGVLLALLLPKKLDKDMLSTGGWVGDALKTGSVIILITGAGGAFGKMLQTSDIGEILGSFASDYRIGLWLPFMVAAGIKTAQGSSTVALTTTASIIAPLMLVLGMDTEIEKAMVVISIGAGSAVVSHANDSFFWVVTQMSGMNVSQGYRLQSVGTAVLGLSAMILLTLLSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY22</accession>
    <name>A0A654DY22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025025864" evidence="1">
        <location>
            <begin position="28"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="33"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="248"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="464" mass="52164" checksum="AC4C801DE6755A53" modified="2020-04-22" version="1">MMTKTNTLKIILSFLVSASLFGCQTEAKDSAPWVDLFDGETLTGWSKIGGDATYKVEDGAIVGTTVSNTPNTFLRSDELYGDFILELEYKVDPSMNSGVQIRSNSFDYYLNGRVHGYQIEIDPSERAWSAGIYDEARRGWLNTMENNPEAQKAFKQNEWNHYRIEAIADTIRTWINSVPAAYLVDDKTATGFIGLQVHSIKEDSQEGKQIMWRNVKILTSDLGKYAKSSPLQPVVTKNNLTIDEEKKGWKLLWDGKTSNGWKGAKLDAFPEKGWVMEDGVLSVLSSGGAESRAGGDIVTEELFSDFELKVDFKLTPGANSGIKYYVDTEINKGPGSSIGLEYQILDDELHPDAKLGNHEGSRTVSSLYDLIQADTNKPIKPIGEWNTAHIKSINNHIEHWLNGVKVLEYERKSPEYRKLVSESKYVKWKDFGELDRGQILLQDHGDLVSFRNIKIRPLDKNTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYA8</accession>
    <name>A0A654DYA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="25306" checksum="971F48744659063F" modified="2020-04-22" version="1">MTKIIRKTLPRDISVGVLVIIFAIVFFLAGQLFEKNQPNIEQFTSIYLGEFLVSTAVIVMILILWEEILFPVKIKPDGDGLIFRNHATKLIVQALIYLIIPAIVVFLVFTYEVSPFRFYGWAAVCTILPVVGKLVSGINNYNDFLKLTTSSIAYKNNEKEGVIELKDIQQIRMIKDDSNDLQKLELDLTSGAPITIDLDEMELEAYYESIEEYIKTHYKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP2</accession>
    <name>A0A654DYP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="269" mass="31471" checksum="398A9F2283B74B6B" modified="2020-04-22" version="1">MPANLNKCKSDSVISMKQIISFLLRKIPRKYLQLVSHHGLRVLALFYSGNNVECTVCHSTFRKFLPYGRKSRENALCPKCLALERHRLIWLYLERKTDFFTRKNKMLHIAPELCFMDRFESLPNLDYITGDIESPLAKVKMDIHDIPFEENTFDVIFCNHVLEHVEDDILAMKEMRRVLKPGGWAILQVPFFYPLKKETYEDKSITSPAEREKAFGQDDHVRMFGEDYGARLASAGFKVTEDKLVMELSEDEVSRFALPRQEIIFRVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYR4</accession>
    <name>A0A654DYR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoM</name>
        <name evidence="7" type="ORF">MARINOS108_12095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="141"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="541" mass="59679" checksum="B1907624ECCC4B15" modified="2020-04-22" version="1">MNYLLSWMIFLPLAAAFVVGVLPASSRQAIRWIALGATLVQLVFGLILFFGFDGSIQPKAWADAFQYVELAPWFSLQLGNYGSLQVDYSVGVDGISMPLIVMSTILLVIGVVSSWKLTTKVKGYFMLYLILSGSLIGCFASLDFFLFYVFFEFMLLPMFFLIGIWGGPRRSYASIKFFLYTLLGSLFILIVMIGLYLSVGSIDGAGAQTNTFSLIQMMDGVYLSNTLLSPESGYVLWGMPLRSVAFILLLVGFMIKLPAVPFHTWLPDAHVEAPTAISVLLAGVLLKVGGYGLFRICYAIFPDAAISMAYPVAVIGLISIIYGGLVAMAQNDIKKLIAYSSVSHMGFVLLGLAAITSEGVSGSLFQMVSHGFISGALFLIVGVIYDRTHDRQIENLSGLASKMPQYTFFVVLFFFASLGLPGLSGFVGEVLVLMGAIGTESLTGIFPRWIGMVAVLGIIISAGYYLWTLQRMFFGKFWTREREWESLMRDLTIREWLMLAPLAVLVVLFGVFPSLILDPIDNSIQFFVERVLDQGHYFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ20</accession>
    <name>A0A654DZ20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS superfamily sulfate permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_110005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="9"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD15827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="518" mass="55389" checksum="85CF2BD02270F631" modified="2020-04-22" version="1">MKKYFGENLKNDLPAGMVVALVALPLCLGIALASGAPLFSGIIAGIVGGIVVGALSGSQLSVSGPAAGLTVIVLNAIESLGAFESFLLAVFLAGLIQFILGMLKAGIIGHFFPSSVIKGMLSAIGLILILKQIPHALGDDRDYEGDESFYQPDGENTFTEIIMALQNIDKGALLISMIAIAILILWERPFMRKQKWTNVIPGPLVAVAWGIFANAVLFRQFLPDFVLSSKHLVTLPISSSVSEFLGFLTAPDFSQLLNVNVYITAFTIAIVASLETLLSLDAVDKLDPYKRIASTNQELKAQGTGNMVSGLLGGLPVTAVIVRSTANISSGGQTKVSAVFHGLLLAMSVIFFPGFLNMIPLSALAAVLLLVGYKLSKPSIFKGLYAKGTSQFLPFLITILAILFTDLLIGITIGIVVGLYYVVKANLHQAITLKELGPDNFVITLEKDVSFLNKAFLRKTLRGIPPNSHVVFDETESIFIDEDILETIEDFKKTAINDGISIKVKPAPNTKNPKLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ56</accession>
    <name>A0A654DZ56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="37481" checksum="75A3B80CF5EB9E87" modified="2020-04-22" version="1">MPKYSVIVPVYNRPSEVQELLSTLVNQTFRDFEVIIVEDGSTLKSDSVVAEYQSKLSIAYFIKENEGQGFARNYGFARAKGDYFIVFDSDCLIPSDYFQVVDRYLSSHTVDAFGGPDAAHPSFTVVQKAINQTMTSFFTTGGIRGGASHIGKYHPRSFNMGFSRKVYEKTKGYIIPFMGEDMEFSTRLLKEGFQSVLIPEAYVFHKRRTSPTKFFKQLMYFGRARINLSRFHAGQVGLVHLFPLAFTLGLLVSFCLPVFFFDSLGFTGLIGYLFYLSIVFSESLMVNKSLTVAALTPVMTLLQMTGYATGLVYEGIRKLMGIDPNTRYIDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZC9</accession>
    <name>A0A654DZC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23907" checksum="BE3E4CAB27368459" modified="2020-04-22" version="1">MATPYKVKESRIDDISLLEPEATYSYADYLKWTFEERVELIKGRLFKMSPAPRRTHQEIAGAIFTEVHHFLKTKNCRVYHAPFDVRFPSNQGDKDNQTFTVVQPDICVVCDPAKLDDAGCKGAPDLVVEILSPTTASKDLNEKYHLYEEHGVKEYWVVYPGENVLEIYELIDRKYISRGKFVREDQVRSNVLKGLVLNLEDVFEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG0</accession>
    <name>A0A654DZG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4796" checksum="E586544EA01DD56C" modified="2020-04-22" version="1">MKDWQMRFNAARKESELHFHHLDHALQRTSSIYPLSEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZI3</accession>
    <name>A0A654DZI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="54" mass="6175" checksum="4922E0CEB2AAE437" modified="2020-04-22" version="1">MNGSQDEVVSAQLTDKELLKQFKAVEQLDAEDKHLVKTFIDAFLTKRQVQKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM1</accession>
    <name>A0A654DZM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="101" mass="11383" checksum="FE6915F7E7D2D528" modified="2020-04-22" version="1">MNYKDKYLPVDPDFIEYCDSQVTLKSSGKIHFFNDQHKVDDVKGPLSTLNNTSEGYFLELENGNSVRLDKIITLMGKPGPGYAEYDSYANACLTCEDLGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZV7</accession>
    <name>A0A654DZV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY</name>
        <name evidence="3" type="ORF">MARINOS108_120236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14103" checksum="C8AD64CF1BBD4EA0" modified="2020-04-22" version="1">MRLLIVDDSSIMRRIIEKNLKDYDIEIIGMAPDGASAVKIVKEEKPDVVTLDITMPGMDGLACLDEIMLMHPKCKVMIITALSDKLTGLRALDKGARGFLYKPVNADDLAKAFDRLLKRNENKQSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW3</accession>
    <name>A0A654DZW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ORF">MARINOS108_110070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="33821" checksum="7F144259EE5AF541" modified="2020-04-22" version="1">MQVEIDPHSGYCFGVEFAIQMAEDEMEGGQELYCLGDIVHNAMEVERLYAKGLRTITREELEELHDCKVLIRAHGEPPETYETALKNNIELIDASCPVVLKLQNRIKHSYDKAVTSNGQVVIYGKPGHAEVIGLTGQTNDEAIIITSEEDLDQIDFARPVTLYSQTTKSTKGFYHIKELIEERIKKEKGEFTVEDFNANDSICRQVSNREPKMVEFSHKHDVVLFVSGKKSSNGRALYNVCLENNTRSYFIENETEIDLDWIRQEDRVGICGATSTPRWLMEKVADFLQAQEPQLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZW7</accession>
    <name>A0A654DZW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome C oxidase Cbb3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MARINOS108_11894</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit, denoted as copper B.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="10">Binds 2 heme groups per subunit, denoted as high- and low-spin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045278">
        <property type="term" value="C:plasma membrane respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004677">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003468">
        <property type="entry name" value="Cyt_c_oxidase_monohaem-su/FixO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF29">
        <property type="entry name" value="PTHR10422:SF29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02433">
        <property type="entry name" value="FixO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00780">
        <property type="entry name" value="ccoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00781">
        <property type="entry name" value="ccoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="14">
        <location>
            <begin position="32"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="15">
        <location>
            <begin position="552"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604677-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD14343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="728" mass="83142" checksum="770D6A1C0F42CE19" modified="2020-04-22" version="1">MSTTTLTNPPEEKGTVNNGLDTFYYDNSIVRMFLIATTVFGVVGMSVGLLAACQFFWPELNFGLQYTTFGRIRPLHTNAVIFAFVGNGIFMGVYYSLQRLCKARMFSDLLSRIHFWGWQLIILAAAITLPLGYTTGKEYAELEWPIDIAIAIIWVVFGINMFGTILKRRERHLYVAIWFFIATFVTVAMLHIVNSFELPISFMKSYSWYAGVQDALVQWWYGHNAVAFFLTTPYLGLMYYFIPKAANRPVYSYRLSIIHFWALIFIYIWAGPHHLLYNSLPNWAQSLGTVFSIMLIAPSWGGMLNGLLTLRGAWDRVREDPILKFMVVAVTCYGMATFEGPMLSLKNFNAIAHFTDWIVAHVHVGGLGWNGFMTFAMLYYLIPRLYGTQLFSKKLANVHFWVGTMGIIFYTLPMYWAGFVQSLMWKQFAPEGTLVYSNFLETVTQIMPMYMLRAFGGALYLTGVFVMVYNLIKTAQAGTFIRETKAEAAPLTKNYRPAKSEHWHRRIFEWRPITLLVWSLVAVAIGGIIEIVPTFLVQSNVPTITSVKPYTPLELNGRDIYVREGCYTCHSQMVRPFRSETERYGEYAKAGEFVYDHPFQWGSKRTGPDLLRVGGKYPNSWHYYHMLDPASMSPGSIMPPYPWLFEQDWEKELLPKKITAMQTLGVPYAEGFQDEAVADAEQQAKSISDDLATQGVRVVPDKEIVALIAYLQRVGTDIKNIGETKNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0B1</accession>
    <name>A0A654E0B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
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            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="4923" checksum="9BDDB1A06698D2F7" modified="2020-04-22" version="1">MRAFETCLIGDKKKLNRLYYEILISLPGSIFHSGDPVPNPIFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J7</accession>
    <name>A0A654E0J7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="18111" checksum="40CA41586BF27496" modified="2020-04-22" version="1">MTFLETTALNTAQKEAVMALWNKEYPTTLAVTTVADFDAYLQNLINHNHLLVIDDQNRTVGWFFTFERDAEKWFAMILSADVQGQRLGSQLLSRAQQKHDTLNGWVIDHEDYKKSNGQPYLSPVTFYLKNGFEILNLTRLETPKLSAVKMRWRNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L1</accession>
    <name>A0A654E0L1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024812055" evidence="1">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="321" mass="34765" checksum="85970E7D9BA2BF6F" modified="2020-04-22" version="1">MKDLLFYLMITLLVHSAYAQESSYTVNKGSGYARLRIESDGDGTHNNVTNVIESYGYGGASDLNFMISNWNGHYHFAYQTTAGSFNAVRLTKGGGGSNGPNDGYGLIDVYGRDQSNYIRLAGYGDSFFKGSLVLGGTSTYARLELLSLASQPTMLVGRANGYPNIMASTDGTGHLIMDSRSNAYASLNHYSSADVTLAYGGGNVGVGVVHPTEKLEVKGTIRSKEVKVEASPWPDYVFSEGYELPDLGATADFIKANKHLPGIPSAAEVADQGILLGEMNAKLLEKIEELTLHLIEKDKQIDLILERLEAQEGEIDQLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T7</accession>
    <name>A0A654E0T7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008537">
        <property type="entry name" value="DUF819"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34289">
        <property type="entry name" value="PTHR34289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05684">
        <property type="entry name" value="DUF819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="414" mass="44464" checksum="7CE1F38BB8FF3B20" modified="2020-04-22" version="1">MNEPLLTNDAVIFGIIMLILGFVFTTSSSESTFWKKFYAVVPALLMCYFLPSLLGTFGIIDPGTSRLYFVASRYLLPASLVLLTISVDLKEIVKLGPKALIMFFTATVGIVLGGPFAILLFSYIAPELVSAPPPNEVWRGMTTIAGSWIGGGANQAAMKEVFEVNGELFSKMVAVDIIVGNTWLGVLLAGIGYSKYIDRKLKADASAIEAMKQKMEAFQLKNARIPTLTDLMKILMIGFICTGIAHYLSDWIAPTISEHFPFLDKYSLTSGFFWIVVIATTLGVFLSFTRAKELEGAGASKIGSVFIYILVATIGMHMDIMAVFDDPGLFLVGLTWMLFHVILLTIVAKLIKAPYFFVAVGSTANVGGAASAPVIAAAFHPALAPVGVLLAVLGYVLGTYGAYLCGLLMGAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E144</accession>
    <name>A0A654E144_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="355" mass="40170" checksum="BE96C7C7627F362B" modified="2020-04-22" version="1">MTADHKSFDLSKTAYFLLILVSTVIILIYSEDYIVPFIIALIVWFIIHELRENIQQIPWMKRNCPMWLQSAIAFMVINVVILIIIELLMYSMSNLMSSLELYESNLDKSLMEVNALAGMDVTSHLYNYLEKLDLTELASSLADYITVLLGDAFLILLYVLFLLIEESIFPEKLKRLYPSEKQQRKTVRLFNKMDHNISRYLTLKTLVSLLTGLLSYFALIAFGIDAPIFWALLIFVLNYIPTIGSLIATLFPACFAILQFGELAPFVYILLSVGAIQVIVGNVIEPKVMGNSLNISSLVVILSLTIWGAIWGVMGMILSVPITVMMIVVFEEIPSLRFIAVMLSEKGELNALEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E170</accession>
    <name>A0A654E170_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glnS</name>
        <name evidence="11" type="ORF">MARINOS108_140153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="9">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="10">
        <location>
            <begin position="338"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="551" mass="63757" checksum="43FB7F3BF3354697" modified="2020-04-22" version="1">METVKRESLNFIEQLIENDLNSGKHQAIQTRFPPEPNGYLHIGHAKSICLNFGLAEKFNGKCNLRFDDTNPEKEDVEYVDSIKKDIKWLGFEWDGEHYASDYFGTLYGFAQALIKKGSAYVDDLSQEAFNEIKGTPTVPGKHSPFRERSVEENLLLFEEMKDGKYKNGEKVLRAKIDMSSPNMHMRDPILYRIRHTEHHRTGNEWCIYPTYDFAHGQSDSIEHVTHSLCTLEFEVHRPLYEWLIKELEIFPSKQTEFARLNLSYTVVSKRKLLELVEGKYVAGWDDPRMPTISGIRRRGFTPEAVKTFIKKVGVARRDGITDVALLEHAVREDLNRRCNRVFGILDPVKLVITNWPEDKEEVMTAVNNPEDEAAGTREMLFTRELYIDRADFMEDPPSPKKWYRLGPDREVRLKYGYIIKCTGFDKGADGEIATIYAEYDPETRSGQDTSGKKVKGTLGWVSVKHAVHAEIRLYDRLFHTENLNDIEDDFKNHLNPNSLEINDKVVLEGSLKNAKVDDLVQFERVGYFRVDEDSTADKLVFNRTITLRDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E1</accession>
    <name>A0A654E1E1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="58"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="357" mass="39554" checksum="594B5B053FF3711D" modified="2020-04-22" version="1">MKRFFIGLTIVIILGLFVGTGYFLYQKSEEPPIIYETDTPFKTDIIKKTIATGSIVPRKEVALKSQVSGVVEKLYLEEGAQVKIGDLVAKIKIIPNVVALNNAQAQLQTAKINFDNSEKELKRQKELFDEKVISEFDYNQFLLDFNLRKQEVEAAENNLELIKEGSSQKTGNVSNLVRSTVNGMILDIPVKEGTFIIESNTFNEGTSIASVADMSEMIFEGKVDESEVGKINVGMDLSLSVGAIEGVIFNAKLEFISPKGESDEGAIKFDIKAAVDLKEEYFLRAGYSATADIILQKASDVLAIKESNLIFEGDDIFVEVRTGEQQFERRQVKTGLSDGINIQIAEGLTEEEVIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q2</accession>
    <name>A0A654E1Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type bacteriocin/lantibiotic exporter with double-glycine peptidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_120535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="178"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="491"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="525"/>
            <end position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="724" mass="81539" checksum="AE4091A6F2654FEB" modified="2020-04-22" version="1">MNNHQIIKVIQECAGYLNLEVSSDVVQSLERNFREYDNLDLIEFIRDTVESGNDCGIIFLEKHLKESLFLKSMSSHSAPVMVFAKDDELAPVLITRKGKKYLFTKIREEGVEKWEGDDLTALDMACTEKLEVIFLAIFDHQSLVSSDKDYLDKTPVSAVYRLYKLLAAERQDILYVYIYAALIGLLGLSLPLGIQAAIELISGGVLFSSVYVLIAFIILGVIATGVLQVFQITIVEYLQRRVFTKAAFEFAFRVPRIQMESVLNLHMPELMNRFFDVITLQKGLPKLLIDLSTGIIQIIFGLILLSFYHPFFVFFGLGLLGTLFSIFYLTGPQGLKSSIVESKYKYKVVYWLEEMARTLYSFKLSGNTNLPIKNTDLNVNSYLKHRSAHFKVLIKQYSFILLFKVVVTGGLLIIGTILVINREITLGQFVASEVIIILIINSVEKIIMYMDVVYDMLTAVDKIAQVTDLPLEPSGGIDIPASQLNEKGLSVEIKNLQYTYPDRDHPSISDINLSIAPGEKICISGGGNSGKTTLTNVIAGIHTKYEGVITYNRYNLKDLDRTHLRDQIGKNVSQEDIFEGTILDNILVGKPFSNMSMAMEAMDKVGLMDQIHEWPEGFNTPIRSAGKGFSSSFINKLILARCLAKQPSLLILNDFFNSAQKHERLKLIEILTNPEIQRTLIVVSNDPLIMAAMDRVIYMDAGKIIADDTFENVLKNENILKNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E208</accession>
    <name>A0A654E208_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gliding motility lipoprotein GldB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="37455" checksum="C79B73E8BA737385" modified="2020-04-22" version="1">MRTVIITIPFLLFFACGPECKNENAIASTPVSIEVERLEAAFFSQDSPEGIENLLEEYREFSRLFLDSDQYPTDSILAAKIFRLIQNPSIDTLYNEAVSEYSDFDPIREDLEMAIGKMTTLFPETRVPKIQTTVSGLYKDLFISDSLILIGLDFFIGPKATYKPLEIPGYVLKRYNKEHLSSIVVKFLAGNQVYKGKSSSLLSEMVDFGKTYYLASRLVPCTQDSVWLGYTSRDMEVIDENEAVIWANLLENEVLYETNHITKRRFLGERPNVYEISQECPGRIGAWVGWRIVESYMKNNEVSIEELLADTDNEKIFRLSGYKPQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B3</accession>
    <name>A0A654E2B3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ORF">MARINOS108_20382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="114"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD18679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="286" mass="31712" checksum="2D199A308840A514" modified="2020-04-22" version="1">MSAPYLTEQNIRYFIKTALSEDIGDGDHSSLGSIPKNQVSHARLLIKDHGIIAGLTLAERIFHYVDKSIKIDFKKKDGDFVSNGDIGFTVEGKAQAILSAERLVLNCLQRMSGIATYTHRMNLLIRGSRARLLDTRKTTPNFRLPEKWAVLIGGGVNHRFGLYDMVMLKDNHIDYAGGVKEAITETVAYLKANNLDLKIEVEVRNLEELEQVLEVGHVHRVLLDNMLPSAIREAIGMIRGRMETEASGGINEKNIGDIAETGVDFISVGALTHSYKSLDISLKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B7</accession>
    <name>A0A654E2B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="86" mass="9883" checksum="DE8631285B378687" modified="2020-04-22" version="1">MDNALNFSIVSGSEGDIHVSNDALFIDEKSIGKEFKISTLALLNDDLYFSQTTLLGSDFIDRDKNKRKFIPIRLWKIKELNKNTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2B9</accession>
    <name>A0A654E2B9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="508" mass="59959" checksum="3B2968B7D73CCDEC" modified="2020-04-22" version="1">MIKSEALIYLVNSMTKPEKKAFRIATDSSDGAYYLQLYDLIDSNKEITSEQLKEEFSIKLPKASFDTSATHLYKTLLNTMLDLRKDQDSYYSLFDMILKARILFEKSLYQECFDTLKKVKKNATKYENYYALLISSRLELEYQLALNFPGLDEKDLLHKHFKVSETLRIIQKIHQQSALYELLKYRMLHRGNARSEKQKTELNDLVVSEMSIVSSSNIQNFEISKLHQLFQANYLISVGDYKSAFHSFNELNNLHEANKHLWSNPPIYYVLSIEGVLDSLRSLREYKGMSHFVQQLEKIDTPFLSFNTNVVCLIFLYELFPFLDRGDFGSCEQLMKKYDAKLLKKVQLLSLARNAELHLYLALIYFGLRDFQKAKKCLSKIIFTNRDYSYLPVFRTIRLVNLMILYELKDTEFIKYESRSIKRDINAAGKEYKIEKKIISFVNKTNLPVSIVKRKRLWENLKKDFEIINHDVYEQQTLRLFDFSAWIESKVRRIPLAEILNNRVSQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H3</accession>
    <name>A0A654E2H3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="211" mass="24635" checksum="4B3DA77FEF0ECB5F" modified="2020-04-22" version="1">MERSIEAMWKEGFLQNGALIAPRVNDIYNRKSMHIIEKFERMFLMNIWGIIIGSLLLLIGSYFVGALLAGSLVFIMMSYVAYTAYHELKALERIDKGQSSYAFLKSFKNWISNNIERYGKMYKVVYPLFILAFYFGIWFSDVFADKRQMVAENSNNVFFGLHTYTTIVVIIMALLMSLFSKQIHRRDVKIVYGRIIKKLDLALAEMEELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H8</accession>
    <name>A0A654E2H8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024886679" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="15879" checksum="AA70A2510308A639" modified="2020-04-22" version="1">MKPTSILIPFILLLISSCSQYDCCVLIDDERSLVGKWQVFEYGYSPGGGYIVEQVPDSPVQILEFKAGGVFSSNYTGLKDFNTYRVLVDSATDGYILSLAEVRTGRKSKETAEYSLVGEGDHLKLYYRYCIEGCHIGIKPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L8</accession>
    <name>A0A654E2L8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">MARINOS108_120518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="22010" checksum="3049BD0DD204523D" modified="2020-04-22" version="1">MKVGLFFGSFNPIHVGHLIIANVAHQSTELDQVWFIVSPQNPFKKNKNLLHEFDRYDLVQAAIEDDYHFRASDVEFQMPRPSYTVDTLAVLTEKHPDHSFTLIIGEDNLGSFTKWKNHQVILDHYGLIVYPRPNAQKSDLTEHSNVRLIEAPEMDISATLIRKMIRANRSIKYLVPARVEEMIQARKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M7</accession>
    <name>A0A654E2M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sua</name>
        <name evidence="10" type="ORF">MARINOS108_12058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="319" mass="34952" checksum="97FC1C5D330DCB5E" modified="2020-04-22" version="1">MAEIGTNIEQAAALLKAGKLVAIPTETVYGLAGNALDESAILDIFKVKKRPKFDPLIAHTDSLEKIKGIVTHIPDKALMLAEAFWPGPLTILLNKKSHIPDILTSGLSDVAVRIPRHPLTHSLLSQLDFPLAAPSANPFGYISPTSAQHVQDQLGAHIPYILDGGSCSVGIESTIIGFNEQEQPIVYRLGGKKIDDIEQVVGKVKLRINHSSDPIAPGMLKSHYAPSKRLIIGNLTELVPRFHKRNFGVISFHQSFDGLTADRQIILSKTRNLDEAARQLFGALRTMDQKDVEFIITEKFPDMGLGQAINDRLKRAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M9</accession>
    <name>A0A654E2M9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">xerC</name>
        <name evidence="13" type="ORF">MARINOS108_20499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="104"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD18985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="33862" checksum="E576379BF8DBDA92" modified="2020-04-22" version="1">MIDTFLKYLRFEKRYSEHTLTAYRKDLTQLEIFLSEEFETSDFKEVQHAHLRNWMVNLMESGLEPKSVNRKMASVKAFYKFLLAREYVASNPTGRLKSLKVDKKLPSFVRESEMITLLDQIEFSRDFFGARDRLILELLYATGIRLTELINLSDPDVNLYQGSIKVLGKRNKERVIPMAEFIVKSIKEYQQLRNAEFGFCDYLFVTDSGNKLYPMMVYRIVKKYLDQVTTIAKRSPHVLRHTFATHLLNKGADLNAVKDLLGHTSLAATQVYTHNSMEKLKSVFDQAHPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E309</accession>
    <name>A0A654E309_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="126"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="254"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="491" mass="54468" checksum="6345FF9A1770E5F7" modified="2020-04-22" version="1">MRKVLYLIVLLSCTMAFGQKDKKITEKTVSKASIQAHLKFMSSDALKGRDTPSPELDIAAEYLRTQLELYGVKPFAEFPDYFQPVSMKKIKKPQTGTITLDSATYTIGVDYLLISGGNLEWNGEIAFLDYATSEELEKADVKGKIVVANTGDGEEQSPRAWFAMSREKRANAKEAGALGLIELYNSPQIPWQLLVNYLSRDQVILDDGIEDERDEFAGIWLNNANREASPSFANTSKLDIKMAGAGVERFVSQNVVGYVEGTDPVLKKDYVTFSAHYDHVGVGRADSTGDDIYNGTRDNAVGTVTVLEAAKNLAMYPTKRSSLFVMFCGEEKGLLGSQWFVDHSPLPLSDIVFCFNSDNGGYNNTSMATVIGLDRTTAQGLLVTAIESYGLTAGDDANYKEQGLFDRSDNVSFAKKGIPAPSFGMGVDAFDEQVLRTYHQPSDEFDTIDMDYLYTFYRAYVFAGRSIGNMKETPLWVEGDKYYEVGKELYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B4</accession>
    <name>A0A654E3B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA recombination protein RmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rmuC</name>
        <name evidence="6" type="ORF">MARINOS108_20420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="456" mass="52416" checksum="1D2D00B20422A1DF" modified="2020-04-22" version="1">MEFDSLMVLIIGLVAGVIIGFLIAKLQSKGVVDDAPKLRMELQMEQERSNKLTAELAQLNGELREERERFMDINSEHSSLKANFKNLQERLTEQKEEVNNLQQRFAAEFKNLANEIFEEKSRKFTDQNKSNLDNLLKPLGEKLVEFERKVEQTNKDSLERSTALREQIISLRELNQRMTKETENLTKALKGDTKVQGNWGEVILERILEKSGLEKDREYFTQESFTNEEGRRLRPDVIIRLPDNKNLVIDAKASLVAYEKYVNSDSEEEREQHLKDHLISLRAHIKGLSEKSYHKLFESGTLDYVLMFVPIESAFALLVQQGGELYNEAHNKNIIIVSPATLIATLRTVASIWKHEYQDRNALEIARQGGALYDKFKAFVDDLMEVGRSLDKSKQQYTEAMKKLYDGKDNLIRKTERLKELGAKTSKDMNEKLLERADASSAIKKPEETPSGNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J3</accession>
    <name>A0A654E3J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17504" checksum="F732E95E7E5A1D7F" modified="2020-04-22" version="1">MKILNQYLIAASFLVLLSACGGGGKSRIEQIKEQSKVEPSDPYENWKQFHGVGPVKAFTLPTEVDQQLVAKGQEIFESKCTACHKVDKKFIGPSPKDILSRRNPAWVMNMILDPGKMVQEDAIAKKLLMEYNGSPMANQNLSEEEARSVLEYFRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3S6</accession>
    <name>A0A654E3S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3'(2'),5'-bisphosphate nucleotidase CysQ</fullName>
            <ecNumber evidence="7">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
            <shortName evidence="7">PAP phosphatase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">cysQ</name>
        <name evidence="8" type="ORF">MARINOS108_20561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts adenosine-3',5'-bisphosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the inositol monophosphatase superfamily. CysQ family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02095">
        <property type="entry name" value="CysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006240">
        <property type="entry name" value="CysQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01331">
        <property type="entry name" value="bisphos_cysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="27965" checksum="120BAB8FED78BA9F" modified="2020-04-22" version="1">MDFNNLLEIAKIAAQKASVEILRIYDSGDFSIEAKSDHSPLTLADKASHQAIVKELEPTGIPILSEEGNSIPYETRSQWDYFWMIDPLDGTKEFIKKNGEFTVNIALIHENRAILGVVFTPVLNDLFWAVKGDGSFKNGDRISSNHFSLSDKGLNVVASRSHLNDETQAYLDELNEPQTLSKGSSLKLLMIAEGVADLYPRYAPTMEWDTAAAQIIVEEAGGAVIVKGTNEPVAYNKQNLLNPHFLVTGRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3V7</accession>
    <name>A0A654E3V7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HupE/UreJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032809">
        <property type="entry name" value="Put_HupE_UreJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13795">
        <property type="entry name" value="HupE_UreJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22345" checksum="E64F0E5ACB816901" modified="2020-04-22" version="1">MFDIFAFHMSEFQIYYDLGLQHILDKNGYDHIIFVIALCALYQAEDWKSVLTLVTSFTLGHSITLALATFSIVEVDPDLIEFLIPVTIFITAVFNLFSRTENTHVSIRNYFFAGFFGLVHGLGFSNYLKTLLGKDESIITQLFAFNIGLEVGQLIIVASLLVIGFVLVSMAGVSRRDWKMVISAAVAGISLVLIIESNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N3</accession>
    <name>A0A654E4N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032272">
        <property type="entry name" value="DUF4834"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16118">
        <property type="entry name" value="DUF4834"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="85" mass="9926" checksum="B8BF595998918324" modified="2020-04-22" version="1">MLKFLLIIALISYLIYRVGGFLFKILFLGAQQQRQQYQSTGQTHQQHARRRAAGSNLDIDYVPGDRKNEKKDFRGGDYVDYEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T0</accession>
    <name>A0A654E4T0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnogalacturonan acetylesterase RhgT</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhgT</name>
        <name evidence="2" type="ORF">MARINOS108_90033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="32"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="252" mass="28741" checksum="CFFED925A18BACFE" modified="2020-04-22" version="1">MIRVIWKWAIPLFAGLLMSFGLLQEQQTVIYLIGDSTCAEKEVNAYPETGWGMPFVHFFDESIKVDNRAKNGRSTKSFMDEGRWEAVLKMLNSGDYVFIQFGHNDEVPSKVGRYTTPEEFQANLRGYVIDTRKKGALPVLLTPVSRRSFENGELVDTHEHYAQLVREVAQSNDVPLIDMTTLSMELVRNLGETESKWLYHHLDAGEHPNYPQGKSDDTHFNELGARKMAQLVLDGIRELNLELKNHIVAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V3</accession>
    <name>A0A654E4V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="553" mass="59912" checksum="0A9F410DED64BDB0" modified="2020-04-22" version="1">MMIRAITIHEKDDLAVALTDLPKGAEVTVNGKAITLQHTINAKHKFAMKDFHAGDEVHMYNVTVGKAKETIKTGEAVTTSNLAHQSESFSAEDKSANAFQWTSPDVSPWKDATFMGYHRKDGQVGTANYWLVFPLVFCENRNIETIKKAFDKALGLEKQDPYVALVENMVDRFRKNELSDASVLDFKLDTTTHISKARVFENIDGIRFLTHQGGCGGTRQDAETLCRLLSGYVNNPNVAGATVLSLGCQNAQVQMFTDALHSINPTIDKPIIIHDQQDTGKEQELIKNSITETFMALIEANKQTREPAPLSKLTIGLECGGSDGFSGISANPAIGYTSDLVVALGGKAILSEFPELCGVERELINRMDTQELAVKFVDIMRRYEKSAVEAGSGFDMNPSPGNIKDGLITDAMKSAGAAKKGGTSPITDILDYTEYAHKPGLNLLCTPGNDVESTTGLAGSGANIILFTTGLGTPTGNPISPVLKLSSNSKLAAKMPDIIDIDTGKVITGEKTIEEMGSEILNYIIEVASGHKTAKSMDLEQYDFIPWKRGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4V5</accession>
    <name>A0A654E4V5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="148" mass="16885" checksum="43121C86ABE86178" modified="2020-04-22" version="1">MKPTKPVMNTFLKLFGVVVMAVLVVACSGKKEKETPEDAMTELKDSFEEEKKDLKYELEEIKLDVEKELDNLDDKIAEATDQNKTLLEKMKADLNEKADDLDRAIDKVENSTKQAWNDTREFAAETSEDVKSSLKDFGEKIKEKFSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X1</accession>
    <name>A0A654E4X1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Levanase</fullName>
            <ecNumber evidence="7">3.2.1.80</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sacC</name>
        <name evidence="7" type="ORF">MARINOS108_90049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.80" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051669">
        <property type="term" value="F:fructan beta-fructosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="34"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="410"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="500"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="744" mass="82840" checksum="79C3C843B4F053E7" modified="2020-04-22" version="1">MHLLTKLFLIFIALIFGHLAKAQTYTEQYRMQYHFSPERNWVNDPCGMVYLSGTYHLMYQYNPHGTQWGNMSWGHATSTDLMHWKEQGVVLYNDSQGAIFSGGAVIDYHNTSGFGDSAMVAIYTSAGQTQKQSLAYSLDQGINWTKYSGNPVLPNKGIIDFRDPTVLWHESTHTWVMTLAEQDQIGFYSSPNLKDWTYQSAFGKGMGAHGGVWECPDLFQLEVQGTSRKLWVLMVSINPGSPSGGSGTQYFVGDFDGKSFTLTPEFELLLNPQPTDEVLVFEDFESGYENWTVTGTAFGHAPVAGTLPDQQLVTNYQGDQLVNSYLNGDAATGSLTSAPFIIESNYINFLIGGGHHPDLTAIKLIVDDQVVRSATGSNTEQLRWYAWDVSEYAGKSAQLKIVDEVTGGWGHINVDHVYFSDRAIVQKEAFWVNHGPDDYAGRSFQQTPDGRVLWMSWMNNWSYAGNLPTSTWRGGMSLPRELTLKETPAGIRLFQQPAAEVYELRQDTLVIQGDLDALNTALVGRAQSSNQYELRFSINQTNTQSGAGVILAAEGSYYTQIGYDPKTAKVFLDRKHSGVAFSGDYTQLFDFSTSELQSLNFQIFVDQSSVEVFVNDGEELISARIFPTSGATGLRFYGDVGSITEVSHFEYGNIWRGEEALVTFTPKSRVKIFPNPSQGKFRVEGVKSLAHVELIGMSGNRLPFTISTKNEGYEIVLDNETYSGVIILRIVADNQIITEQLINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Y3</accession>
    <name>A0A654E4Y3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquinone biosynthesis protein UbiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_140009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD17389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="33485" checksum="C737F8501D0ED823" modified="2020-04-22" version="1">MRGSYYPMKKSTFLHLRIPFSFFLSPVFFFATAIVSGYNTENFWLVFIILHFLLYPASNGYNSYFDKDEGSIGGLKHPPKVTQELFYASWAMDVLAIGLGWSISWQFAVMLLVYGLVSKAYSHPSIRLKKMPIIGWLAAGVFQGYFTFLMVCLAFSGPEVITELKVQFAGILSTLLLFGSYPMTQVYQHDEDARRGDRTISLILGVLGTFHFTALFFSVSVLLFAFFFQLYYDTQVVFLFILALSPILLFFLVWYMQVRKDPNNADYQRTMWLNFISGACLNIFFIWLIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E508</accession>
    <name>A0A654E508_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_11061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="561"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="749" mass="81806" checksum="0BD0005A50C2E2B8" modified="2020-04-22" version="1">MDLLELSQTDSFNTTDTLWILISAALVFFMQAGFKVLETGLVKSEHRSGIGIKNLMDWVAGSLAFFIIGFGLMFGTSAGGFIGTSFFFGNDLEPGYPLVFFIFQLAFAGTALTIVSGAMSGRTALAPYFIASLFTAVLIYPIFGHWAWGNLLNEDNQPWLAGLGFMDFAGSTVVHSVGAWVGLVGIWMVGPRLGRFTSKGTLIPVKASDYAYSVLGVMILWLGWWGFNGGSALAFDTSVPLIILNTNLAAAGACFSAYLHAKIFQKNQDLIEKIIGGSLTGLVAITACCNVVSPISSLIIGLLAGVIHNISYIIISEKWKLDDPVGAIPVHGFGGVFGTLCVALFGKEEFLMHGRGTQLVVQIFGIIVCFVFTVGVSYLIFLLIKSTIGLRLSPNEEVDGAIFGAQVQSMELDELPEQTVSQVSVRVGERAYNLFKVDEYLNLPRETRINLIKNEGVQYLDDSGNVVPTLKAVRYLSGIIEEQRDKSTTSIDLVELSFYKDKMDVIGNMQDVLLGEEHSITSVFEDSFLLLKPKGKVSSGFYWHGKEKGYNIAIAATSQDPDISSAFITALTISQLNEIVGIKKILAPEKVLEILDQKLTMALGQSKADEEVRKGVEIGMLLVDTVRRRVYYSGSGSGVKLYAKKLDSILTEFKGLDVPLGMSGKAQKKFERVKIDYSKGDAFFLCTEGFPNQLNESGKRYSTTKFRVLLEKGAGKSMADQKINITTELENWKGKEDQTEDILVMGIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E510</accession>
    <name>A0A654E510_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="662" mass="74682" checksum="89EC386A2F9E8271" modified="2020-04-22" version="1">MQTASDQVFDNFELSLKEFFESTELTKPEKATKLASQIDLLSLTRDGLSYLYKKCSDLDEAGIFTGTAWNEPDKLVPYLVKGTLTFGHPSSSFEILSELRLLAMANGDMVSPVMTAEDAQHFLEEVVVHNLEFALKEPSEETRIVMSEREMKKAFNLFGFIMSEIDLGGVYEKLAEEIRLICAQRPIVTRKVRELIRLVDERFDTSGNSKTDESVRHCINAIYGPSKGAKAHSELSDYQYFLSNANMKTLKAEAEAMGYHMSSTGLVSSFHALLLQKLVQEYPDLVPDSLDLNDRGIAEWEKFHELVSTLIMEVVSPDNCQCIYGLARMLGKNLFSRRPVRVGLENLRKIKLNSQVEKRILKSLVNQQPDANALKYLLGGTLRVLGQPLGVGQGNNPTCQSARGMSMWSQHAPAKLIDMIITVATQNNLIMRFENVDLTSNQLGKGLMEKLDYNLDPVSVVLVPHLDKLYNEMMRRTAGRGEDPHKWVNPLMYGQWIQLGFASCYDYLTNSILDFEGFVRIFYAAFHPEFNGQREMVYPNPVGIFITSSKGDMMGFHAISLLRVDQDSTGVVRAYFLNPNNEGRQDWGQGIKPSVFGHGEKHGESSLPFGQFVARVYAFHYNPLDTTDFLSGVPDHLLKDAVALAQESWGKSYIWNQQIKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E522</accession>
    <name>A0A654E522_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r1_2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="224"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="290" mass="33202" checksum="84C935A718385F96" modified="2020-04-22" version="1">MRQLKITQSITNRRESHTLEKYFTEVSNVPMITPDEEVTLAKRIREGDELALEKLVKANLRFVVSVAKQYQNRSLPLNDLINEGNLGLIKAAKKFDETKGFKFISYAVWWIRQSIMQALAEQSRIVRLPMNKSGAINQIRRAYAELEQQFEREPTEEELAEILDMKPSEVRNTLGAEVKQMSMDAPFGEDESGSLLDVLENQTTGPTDGELVFNDSLKVETLRALSTLTAREREVIMMSFGIGHDNPYTLEEIGDAMGLTRERVRQIREKALQKLREPGKNRRLKEFVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C3</accession>
    <name>A0A654E5C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TM2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="6">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="14110" checksum="F71050DFBEEDAD23" modified="2020-04-22" version="1">MKKFLLIVFALGYSFVGLSNGKYAIDDSKVESIMEQAISIDSKVALDNPFSVAGIQEEKNVWIAVALDFFLGGLGVHRVYLGTPPGIIAGYFFTCGGIFGILPLVDLIVLVINNEDISAYVNKKGLIMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5G4</accession>
    <name>A0A654E5G4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="413" mass="45298" checksum="E41AFE2A2458D6FD" modified="2020-04-22" version="1">MTNMTDKKGTWLVLLLLVLFLQTKGQSTTGSAYNIFGLGTLVGEGIGGYRTMGNAGIGSRSTSYVNLENPAALNAISGPTQIFDIDLSLKNLHQSAGGESFSTMLGGLEGMNLWLRTGKGSAITLGAAAFSDGRYDVTDSYVLSSLINSYSVRYQGTGGITRFYLGASQRVTKRLNLGVKGSFLLGNLSSLQTISGNSLVSGLEVEQNRTVRKFIAEFGGQYTIPVPDGQRLTIGATYRPAYQMTFDTENKVIRATYDSLTTVGQEQLTLPEKWGLGIEYQLGSWRISGESQVEKWGVNEGGEGFEYRDQLSFGLGAEFVNNPASVSYFNRISWRAGYEWKTNYTVVRNTNYTNAATSIGLGLPVNRGYGMINLGYQYSSMGTRSNQLIYEQTHTFTLNVSMRDVWFRKPVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5N4</accession>
    <name>A0A654E5N4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uridine kinase</fullName>
            <ecNumber evidence="2">2.7.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.48" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="1">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="24015" checksum="F545CAD62266EDFD" modified="2020-04-22" version="1">MSKPLIIGITGGSGSGKTLFLKQLMEKFEEGEISLLSLDNYYKPRTEQPLDERGVENFDLPESLDRERFSNDLRKLKQGEDIIIQEYTFNNDEKKPQTIHIKATPIIVVEGIFTFYYEEILDLLDLKIYIEAPDYLMLTRRITRDAEERGYDLSDVLYRFQHHVTPAFKKYIEPLKHEADVLIPNHNGFSVGLEVIVSYLRQKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Y4</accession>
    <name>A0A654E5Y4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nuoA</name>
        <name evidence="8" type="ORF">MARINOS108_50042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="165" mass="18685" checksum="4C763EEEF6CDFCFB" modified="2020-04-22" version="1">MLEISGFGVALLFIIGGVGFIMTTLLVGKALRPVRPNVEKETTYESGEDPVKSAWSIFNIRFYVVALIFLLFETELVFLFPWATVFADPEMNAETSGLWGMFSLIETFIFIGILFLGLIYVWANGMLDWVKPKSKAVEFKSKIPLKAYAHINQKEYKVRKQDGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E617</accession>
    <name>A0A654E617_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Negative regulator of genetic competence ClpC/MecB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpC</name>
        <name evidence="11" type="ORF">MARINOS108_20178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="9">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="442"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD18364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="851" mass="95424" checksum="C4D19B3F2D541E52" modified="2020-04-22" version="1">MEAKFSNRVKEVISLSREEALRLGHDYIGTEHLLLGMIREGEGVAVSLLKKLGVSLEELRSAIEQATKGTATSNVKNLANIPLTRQSEKVLKITYLEAKIFKSQLIGTEHLLLSILRDEDNLATQILDKFDVSYDVVKELLEYQTENPLAQSDTDDGDEDTGKIFGGSSSSGGSGSRESGKAGGEKSRTPVLDNFGRDLTKLAEDDKLDPIVGREKEIERVAQILSRRKKNNPILIGEPGVGKTAIAEGLALRIIQKKVSRILFGKRVVTLDLASLVAGTKYRGQFEERMKAVMNEIEKSPDVILFIDELHTIVGAGGASGSLDASNMFKPALARGEIQCIGATTLDEYRQYIEKDGALARRFQMVMVDATTADETIQILDNIKDKYQDHHHVNYTPEAIKACVTLSDRYISDRYLPDKAIDVMDEAGARVHINNISVPKQVIELEEQIEDIKKEKNRVVKSQKYEEAAQLRDREKKLLAQLDEEKNKWEEETRTKRYEVDEENVAEVIAMMTGIPTKRIAQNESAKLLNMKEELKKKVIGQEDAIMKLTKSIQRTRVGLKDPKKPIGSFIFLGPTGVGKTEMAKVLSTFLFDKDDSLIRIDMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLDDGILTDGLGRRVDFRNTIIIMTSNIGVRDLKDFGAGIGFSTSSKRDNAEDVMKSTIQSALKKAFSPEFLNRLDDVIVFNTLEREHIHLIIDITLGKLFKRVVDLGYHVELTKKAKDFISDKGYDPQYGARPLNRAIQKYLEDPVAEEILKGEIQEGDTLVADWDGKAEVLHLKLKKKKVKQEDKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E682</accession>
    <name>A0A654E682_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_90154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="270" mass="29387" checksum="6E80308D206D7221" modified="2020-04-22" version="1">MANNLLQGKRGIISGALDENSIAWHVAERAHEEGATFTLTNAPIAMRMGAINQLAEKTGSEIIPADATSVEELENLFTKSQEILGGKIDFVLHSIGMSPNIRKGRSYGDLNYDWFQKSLDVSALSFHKMMAVAEKQDALSEWGSVVGLSYIAAQRTYPFYTDMADAKAVLESIARGYGYRLGKAKKVRVNTISQSPTKTTAGSGIGGFDSFFDFADKMSPLGNALAGDCANYCIFLFSDLSKMITMQNLYHDGGYSNTGISEEIIEQMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E684</accession>
    <name>A0A654E684_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024950897" evidence="1">
        <location>
            <begin position="20"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="437" mass="50141" checksum="AEA9151686A75B62" modified="2020-04-22" version="1">MARLFIFFGFFLICMPSFGQTKVIVPYPNDPSKAKEIYYILEGDSSRIHGDYKQYSPSGKVIVTGTFVDGSKEGTFYNFYEDGSVQRETTYTDNLRQGVTKIFDPNGVIIQEATFLNDTLVGELRLYDTEGKLKGTSHFKNGKPEGLVAEYYASGGIKEEVNYANGKPNGTTRHYYENGNLELEAQYVGGLLDGFYKTYYPSGKLEMEALNERGKRSGFIKYYHENGQLKSLGKYENGTLTGDFKSYYEDGSLQKHLKYNDGYRVGKNLEYHENGSIKYEGIFTNKGLNAKIREYNDKGDLLEEKELLNDLPNGKWISYDEKGRPLLLENYQNGKLHGERVVYEKGKIISETSYGFGNKQGEARTYFPNGDIQTIEHWKLNRLEGSFVRYQKNGQKEYEGEYVRNKRNGIWRYYDRKGEPASQEVYQHGQLISSNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6K2</accession>
    <name>A0A654E6K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulatory protein ZraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">zraR</name>
        <name evidence="9" type="ORF">MARINOS108_11567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD13625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="49137" checksum="E0D5342CE03A9DCF" modified="2020-04-22" version="1">MKTKDSVPHEVLVVDDSFETVELIKRNLESVGYQVYTANNVQSAIKLLETINIDLLITDLKMPGENGLALVRHVSENFKWVAILVITGFPSIQGAVESIKIGAEEYLVKSFTDEELFRAVESALNKTNRRKKEGQNPSMQNFGIIGASDGMIGVFNTIAKARSTNATVLIQGESGTGKELVARALHYGGSDSATPFVPVNCGGIPDALLESELFGYVKGAFTGASETRAGFFQTADKGTIFLDEISNTSLAMQAKLLRVLQEKEFYMVGSKKSQKVNLRVVAATNVDLMQLVKKGLFREDLYYRLNIISIDLPPLRERGNDIIQLVEFFLAKYIQELDKSVMRFSPKAINALKEYAWPGNVRELQNLVHRLVILADDTTIDIPDLPEAFRFSASQSKGLDRKLEEVIQEYIGDVLAANQNNISQAAKVLGIDRKTLRERIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E717</accession>
    <name>A0A654E717_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicarbonate transport ATP-binding protein CmpD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmpD</name>
        <name evidence="5" type="ORF">MARINOS108_11717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005890">
        <property type="entry name" value="NO3_transporter_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01184">
        <property type="entry name" value="ntrCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="294" mass="32895" checksum="63C65C60B0164815" modified="2020-04-22" version="1">MALLELKNVSKSFGSGPSQIDVLSDINLSVHEGEFVAIVGFSGSGKTTLINLINGLLFPDKGEVLLHDQRITGPGPDRGVIFQNYSLLPWLSVYSNVKLAVDEVFTHLSKKERAAHTDQYIDMVNLTPARDKKPSELSGGMRQRVSVARALAMNPEILLMDEPLSALDALTRGSLQEEIIKIWSQDKKTAILITNDVDEGILMADRIIPLTPGPKATLGPEFNVPFDRPRDVTEINKDPEYKKLRNEILEYLIEVGATRRQVSDQKYILPDLQPTMPGRIIFKKKKKKETVKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E765</accession>
    <name>A0A654E765_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CDP-abequose synthase</fullName>
            <ecNumber evidence="2">1.1.1.341</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.341" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="34092" checksum="62B4527F3B00F32C" modified="2020-04-22" version="1">MDKVLVTGASGFLGGHLVRHLRVSGYCILAYYRSEASKEILINKVNYLYSIDDLDRPFDDFSIYAVIHLATNYGREKNSCEDLIETNIGLPLKLARLATLGGCKLFINTDTFFTKMDSYSYLSDYTSTKKLAWEYIKSLYPDRRETIFCNMVLFHVFGENDSQSKFIPWLISELMKDSMSPIPLTSCTQTRDFIYVDDVVHAYEQVLKSYSSHRDFQTFEVGSGSSVCLKDFVCEIKDSLNSKGFRTRELAFGLIPQREGEIDNFVANTKDLRNIGWVKRWTWKDAIENLIASHPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8U6</accession>
    <name>A0A654E8U6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="297" mass="34162" checksum="C47EE49A45471957" modified="2020-04-22" version="1">MEISVIIPSFNGLAKLPGLLSCLMKQSVGNFEVWVIVDGSTDGTEEYLSSLEFENTFNLNYKVQPNRGRSATRNQGARLAKGKLLLFLDDDMEPDAHCLAAHLAHHQKFTGSVLVGNQMEDSSILKTDVQRYKAFLSRKWLNQLHTDASGRLVQPFITAAHFSISKELFQRIGGFDESLTDAEDRELAARCVQDNIPIHFDKKINAWHNDLITARSYSKRLHEYEKANSQLQLLHPEFFTSKEKRFSSLQKIVYAFFGQSIWIWMIDHFNVFMVLPLKLRYLVYDWVFTGSSYLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E921</accession>
    <name>A0A654E921_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="218" mass="24812" checksum="393D150FFE224F40" modified="2020-04-22" version="1">MIGLLKIILKILPWLLVVLLLTLMLLEEKLSLDVITGGKDTYQSTILTRVEEMGNLELVKYNFQEVTEVKKAVDKIDFKFFKLPTSLAPDSRAVLISQGSAAGCIDLSAVRKEDIREDNDTLYVTLPTPKLCYFKIDLEKSRLYDLEISGIARNDQKKFMEELYKVAEAEIKASALKMGILEQTRTNARLVLQPLFENLSNKPVVIKFRMDQSIILNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9S4</accession>
    <name>A0A654E9S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="27"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="382"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="599" mass="67846" checksum="9CF87A2F3F3F3DA5" modified="2020-04-22" version="1">MTLKMKKILNIALAGVLILGTTTSCEDYLEAPAKSTLDESKIFSVYTLAKGAVDGIKEPFGQTNSYRGRFLPNYGMNTDVEWNNNSNNPDDNYDLVKYNAKPNNDQMNTTNNAWAMMYSGIERANICIRGLRNYGDVENDENMAYLLGEALTLRAVYYADLVKSWGDVPARFEPITTETLYLPRSSRDVIYKQLLADLEEAATIVPWPNETSSTASVERVNKAFVKGLRARLALAAGGYSQYADGVRLSTDPELDRATMYGIALQECRDVIASGTARLETSFEDLWRKFNQDDVTAGGESLWEIPFASGRGRWLFTFAVRHLSKDKYTGQARGGQGGPLPFVFYDYAPNDSRRDVTCVPYQWKDVSPSEDIAQQEPTGLDQWMFGKYRYEWKNTRVTASNDDGTNFMYMRYAEILLMAAEAAYELEGPDAAKPYLKEIRQRAFDQADWPTQVDAYLGGLSGSAVFDAIVEEHKLELCGEMQRKQALIRWNLLKTKLDEAKQKMYDLRSQSGEYANVPSTLYYRLAENNETLEFYGLERGETDNKSGEYSDNIDWAVVDELDDEKIETIYVGNPDENQFWPIWQVFIDGSNGQLTNDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECI7</accession>
    <name>A0A654ECI7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alanine racemase</fullName>
            <ecNumber evidence="8">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_20397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="11">
        <location>
            <begin position="679"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="8">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="8">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="749"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8 9">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="805" mass="90177" checksum="6ADE3898CA237B33" modified="2020-04-22" version="1">MLISEVASILSAEFINPSHDFEVDTLVYDSRKASSSTHELFIALPGTHHDGHDYIPSLYQLGIRSFLISKRINPRDYPEAAFLLVSDTLVALQNLATYHRKQFDLPVVGITGSNGKTIVKEWLATILEQQWNVIKSPKSYNSQLGVPMSVWNLEKTHQVAVFEAGVSRTGEMEALERIIQPTLGIFTNIGNAHASGFESPEAKIAEKALLFAHCEKLICRLDHTSIVRQLGNLKATLITWGISQPEASINIVPSGSYFNFHYQGQQSTFSIPFSNPFDLENIFHAITAALVLGESNTHIQQAVNKLKPVPMRLELKRGNNNTHILDDSYNNDFMGLSIALDYLRQQPQKQRKTVILSDMLQSGKDPKVLYSDINALLEKHSIDHLIGIGPDIVQNQAAFSMPFEGYLSTHDFLRSAPAFTNETILVKGARDFELERVVHFLEEKNHGTILEVNYEAITHNLKVYRQQLKPQVKLMVMVKAFAYGVGVEEIAHLLQYHKVDYLGVAYLDEAVTLRRKGITLPIMIMNVDWSSFDLLETFHLEPEIYSLSMLRYFLEVTDNPPPVHLKIETGMNRLGFRSEDLDALMTILHQNPQLKVSGIFTHFSSSDAADEDDFTRKQAATFDQAYEKLAEALGYSPIKHALNSAGIMRWPAFQFDMVRLGIGLYGFDSSGTTNQLKPISTLKTKISQIKPVKEGDSIGYSRMGRADREGSIAIIAIGYADGYSRLFGNGNAYVMVNGQKAPTIGNICMDMTMIDVTGLDAREGDEVIIFGAQPNIRELAQWAQTIPYEILTNVSQRVKRVFVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EED4</accession>
    <name>A0A654EED4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Starch-binding associating with outer membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="475" mass="51775" checksum="021D7B0BF7DBAC2D" modified="2020-04-22" version="1">MMKSIKYLFTGIFFVLFATSCDKGFEELNQDPNNPTTVPSDLLTADIIRNAANNLHSTFVGGDMGSTWAQLWTKVQYNDEERYVPRQSVIESTWDNIYEDVISDARSMEILATAEGNDVSKGVALTLQAWGYSLLTDLYGDIPNTEAIRGTEGIFAPAYDEQSVVYDSILAKLDRANALIAGGNGSLNAATDLMYGGDASKWRKFANSLKIRCLMRISGVRDVSADLQATVARPIFTSNADNAAIVYLAAQPNAHPFYETIDYGSRLEWKVSELLVQTLEGFSDPRLAVMAAKNADGNYRGKPNGIQDVPSEDFNYENVSGIGEFYLNPELPGMFMSYAELQFLLAEAAASNYISGDAATFYNAGIRASMEENGITSGVDAYLSQSGVAYSAGASAELIGTQKWISLFAQGVEAWTEWRRTGQPALSPALDAVLSQIPSRYSYPASEQTTNKASYDAAVASQGADVLTTKVWWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EES8</accession>
    <name>A0A654EES8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025635">
        <property type="entry name" value="DUF4293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14126">
        <property type="entry name" value="DUF4293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18185" checksum="D70E051DF2CCFDB2" modified="2020-04-22" version="1">MIQRIQSVFLFLVAAIMVTVLFLPIWNKLDLDAQEKVTLNAFKMVYSSYDEAGEPTVMASVDTFWISALAILAAGIALFSIFQYKARLRQMKLGALNSLIMGGCLGMTYYYSTKGDQMLNPNTAGNFEIGFYIIAAALLFNSLANRFIRKDEKLVRSADRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSI9</accession>
    <name>A0A654DSI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="92"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="435" mass="50052" checksum="8DF5079B02C80FC2" modified="2020-04-22" version="1">MKEQGRIPVGKVSRAAKFVKTGAKVGGNYVKHYGRKIMDKNASREQLDQDNAEDIYESLSELKGSALKVAQMLSMDKNLLPTAYQDKFAMSQYSAPPLSYPLVVKTFQKYFGMAPTERFNSFSKSAVNAASIGQVHKATLGDKTLAVKIQYPGISDSVRSDLKLVKPFALRLFGLNERELDQYMDEVEGKLLEETDYELEVSRSKRISEACQAIPNLLFPQYYEEHSAARIITMDWLEGQHIREFLTTNPTQEIRDQIGQAMWEFYHHQIHHIKAVHADPHPGNFLMRPDGTLGIIDFGCVKEIPEDFYTAYFKLMNKCLLQDDLELVPVLYDLSFIYADDSDKEKQLYVSLFKEMMGLLGRPFHTDFFDFSDDAYFKKIYELSERLGSMKELRNSRHARGSRHGLYINRTYFGLYQLLNMLGAKIRTSKPDWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT39</accession>
    <name>A0A654DT39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">MARINOS108_10252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="73"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="107"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="331" mass="36048" checksum="395CA29C79B544D4" modified="2020-04-22" version="1">MKQVLDKLFKYQSLSREEAFQILSNLTTGKYNNSQMAAFMTVYLMRSITVEELEGFRDAMLELCVKVPVDEYNGIDLCGTGGDGKNTFNISTISSFVVAGAGQNVVKHGNYGVSSVSGSSNVLESMGAKFTNDIGTIKKSLDEAGICFLHAPLFHPAMKNVGPVRRELGIKTFFNMLGPMVNPAMPKNQLVGVFSLELARLYGYLYQKTDKHFVILHALDGYDEVSLTGGFKAIMNDHEEVFQPEDIGLKKLSAEDLYGGETVEEAVAIFKSILNNEGTEPQVEAILANAGLAISVGKQISISEGIEAARESIKSGKALQSFRKFLAVNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTD7</accession>
    <name>A0A654DTD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="71" mass="7320" checksum="8FA9AB4E5C757008" modified="2020-04-22" version="1">MFGCGFPVSMIIPSSLVKDVIGNDGFYALLPEVGDDLTPVMGGVIAHVKQYFLNGILKFAAAGVAVGDGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTN1</accession>
    <name>A0A654DTN1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol dehydrogenase</fullName>
            <shortName evidence="1">HDH</shortName>
            <ecNumber evidence="1">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 9" type="primary">hisD</name>
        <name evidence="9" type="ORF">MARINOS108_10386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 7">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1 3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1 3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5 6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 5 6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5 6">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 5">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 5 6">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="452" mass="48914" checksum="3A1568A7CBDE6EBD" modified="2020-04-22" version="1">MIPVYENPEGEQLVEILQRPSYDFSKIEKVVEPILEKVKRGGDKALRKLALEYDHVELEDLWISEEEFASAADEVPATLKEAIQIAYQNVKKFHEAQRQQQLVMEVMPGVVCSRRSVPIQKVGLYVPGGSAPLFSTVLMLAIPAKIAGCEEIIISSPTNRLGKINPVVLYTAQLVGVSKVLKLGGAQAIAAMGYGTASVPKVDKIFGPGNQYVTVAKQMLAKQDVAIDMPAGPSEVMVVVDKNSDAVYAASDLLAQAEHGPDSQVILVSTSLKKAEEINNEVVRQLAGLSRKKIAEKALSKSAIIVVEGKKEALKIVNDYGPEHLIISIEKAEKMAEKVVNAGSVFVGEYTPESAGDYASGTNHTLPTNGWARSFSGVSLDSFVKNITYQRITKEGLLLLGPTIERMAEAELLDAHKNAVTVRLNKLREDGITGKPDKGSPEGGESLLFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTW3</accession>
    <name>A0A654DTW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-dependent repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="230" mass="26113" checksum="7BE9A8E332E3F7C5" modified="2020-04-22" version="1">MSKNIFTFDFMKLSLAEENYLKAIYHLSDGGDLGVSTNAIAEELSTKPASVSDMIRKLSQKDVVDYQKYKGVQISKKGKQMALQVIRKHRLWEVFLVEKLNFTWDEVHEVAEQLEHIKSPILISRLDKFLGYPTMDPHGDPIPNEHGEIKENPQLPLTELSIESKGIVVKVPDGDPSLLRHLDKIKMRLGSIIQIKDIVEYDQSVLIQIDQSSEVYISGEIAKNIMLAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTX0</accession>
    <name>A0A654DTX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ORF">MARINOS108_10071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="429"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD10490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="652" mass="72897" checksum="AB2A22453A306FDE" modified="2020-04-22" version="1">MEQRKSLAKGDYSANNIQVLEGLEAVRKRPAMYIGDVGIRGLHHLVWEVVDNSIDEALAGYCDDIHVEINKDNSITVSDNGRGIPTDIHEKEQRSALEVVMTVLHAGGKFDKDTYKVSGGLHGVGVSCVNALSTHLKATVHRNGIIYQQEYEKGIPMYPVKEVGKTDINGTIITFMPDSSIFTHSEYKYDTVASRLRELSFLNSGIKLNLVDHRDQDENGADLTDEFFSTGGLKEFVLYLDSTRERLIPEPIHLNNEKGEIPVEVALNYNTSYTENVVSYVNNINTIEGGTHVAGFRRALTRTLKSYADKSGLLEKAKVEITGDDFREGLTAVISIKVAEPQFEGQTKTKLGNSDAMGAVDTSLSEALQEYLEEHPKEAKQIISKVILAAQARQAARKAREMVQRKNVLSGTGLPGKLADCSDKDPAVCEIYLVEGDSAGGSAKQGRNRKFQAILPLRGKILNVEKAQEHKIYDNDEIKNIITALGVRFGMEDDARALNMEKLRYHKIIIMTDADIDGSHIRTLILTFFFRYMRSLIENGYLYIALPPLYLIKKGKQERYAWTEDDRLSIIRELAPEGKEDSVNVQRYKGLGEMNPEQLWTTTMDPESRSLKLVTIDSAAEADHLFSMLMGDEVAPRRDFIEKNAKYAKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU24</accession>
    <name>A0A654DU24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22130" checksum="3A2248802663D844" modified="2020-04-22" version="1">MRFLVFMLITFFLTSCGGETSSSGDRLYGRGEFEQAIEEYTKALETNPSAINHLYNRGRAYEEIGKLDLAEQDFLQVLSLDNQNLNANLSLSKLYYSKKAYNKAVIFADKALELNENSAQGHFLVARAKHQLGYVDSAMESYTLAININAEYGEAYLYRGALKIHKKQSKSACDDIRRAVNLDVPEAKAILKKYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUB0</accession>
    <name>A0A654DUB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="187" mass="21772" checksum="6BCF76A1DD151438" modified="2020-04-22" version="1">MSTEPNDHQLFLEIKGGNLKSYEVIFRRYYAPLARFATSMVRNADIGEEMAQEVFMYIWEKRQQIELRGELKSYLFSSVKNKCLNYIKLELPRQQSMTDLSGISAASESVMFVDDTRLLKKKIQYAIDQLPEKCRNIFVLSRYGGLTYPEIAEDLEISVKTVENQMSIALKKLKETLSDELKNHRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUK4</accession>
    <name>A0A654DUK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase DeaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_10762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="233"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD11953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="572" mass="64029" checksum="8034BE03BDF75011" modified="2020-04-22" version="1">MNNFSKLGLSASIIEVLDQLGFENPTPIQEKAIPMLLTQNPTDFIGLAQTGTGKTAAFGLPLIDLIDENNKATQALIMAPTRELGQQTGKQLMDFSRNNKAINIEVVYGGAAIMNQIKALRKPTQIVVATPGRLIDLIKRKAVNLDSVRYVVLDEADEMLNMGFKEDIDTILSHTLDERVTWLFSATMPAEIRRIVKKYMDSPLEVSVNSEEKSNKDITHQYVTTKTGNKIPALRRFLDMQPEMRGIMFCRTKRETQEIADDLSAIGYGVEALHGDLSQAQRDAVMKRFKTRSMQLLIATDVAARGIDVNDLTHVLHHTLPDQLESYTHRSGRTGRAGKKGISLAFINPREGRRIEELERKIKVKFERIEVPTLEALKSNRIHNWANFIINTKVDDQAEAILQDMQGRFADLSKEDLLKRLITTQLDHIMSQSGDSNNLNESAGGPPDQRDKSKFHRYFVNIGSIDGMTNADIIHFLSDVSGVDRKYFGELSLQKNCAYFDVDSGHDKGMNLKFEGVEIEGRSIRVNRDDDGGLRSKRPSGPKKSYGSGGGGGGRRSARPKKDFGRRSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUL0</accession>
    <name>A0A654DUL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IX secretion system PorP/SprF family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025070129" evidence="1">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="33987" checksum="E9713FFEE1E13F2F" modified="2020-04-22" version="1">MNLLRTITFFGSLLFLLNLTSNAQQRPMFTQYMFNGLVLNPAYAGSHESISATALSRIQWVGIDGAPVTHTFSIHSPIPDRNIAIGAVFSNDQIGVTNRNTLNLSYAYRIEMRNAILSMGLQGGLTSSKVNYDEIGANDPNLQYNGSALLPNFGLGLYLYGKRYYAGISVPTALKNSWAGEGDANNSDGFSSVEVPHFFGTFGFLVDLSPLVKLKPSILVKSVDGAPIEFDFNANLILDDKLWIGVSYRSFDALSLLLDIQLSAQFKLGYAYDYTLSELSQATTGSHEIMLNYRFVFSKSKIVTPRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUN7</accession>
    <name>A0A654DUN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="154"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29181" checksum="5D478751231FC628" modified="2020-04-22" version="1">MKFDRHPPTERLKPYIKYFVVSENELGSEYKVFPSSGLVIGFQYKGRLSAMNGKQEDRLSTSGITGISKSYKTFKNTPNIGTILVYFTETGFTHFASHPTNELYNLSLSLADIFDQGVTKEVEEKLFLATTDLQRIQIVEAFLLSQLKDIQADRLIVEAVKLLYQSQGTIRIQELLEKLHISQSAFEKRFRKVVGTTPKKFASIIRFNAVLDSLNEAKSLTEICYEHHFFDQAHFIKDFRLFTGDTPEQFKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUW8</accession>
    <name>A0A654DUW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferrous iron transport protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoB-type G" evidence="1">
        <location>
            <begin position="34"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="28531" checksum="7BF0C387CDFCF3FE" modified="2020-04-22" version="1">MTPMNDVVDKGCETCAFYNAAQLKKLGINVDNADFVVALAGNPNTGKSTVFNALTGLRQHTGNWAGKTVTRAEGGFLYSDKRFKLIDLPGTYSLLSTSEDEEVARNFILFGRPDVTVIVADAARLERNLNLVLQVLEITDKAVLCLNLMDEATRHGIKIDERTLAKDLGIPVVATSARSNEGIPELIQTIYEVASNQIVCKPHRIKSLPAEVDQAVDELSKKILKTYPDLPNSRWVAMRLLDGDQQILNALKNGDFVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV00</accession>
    <name>A0A654DV00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane lipoprotein-sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="29627" checksum="2B94BEBEE662E6F6" modified="2020-04-22" version="1">MKWFLRQNEDITMKLAFAILILCSAFLQTNPDAGKILEKVDYNMTSDTQIVESDMVIHGRRNSRTVTSKGYSKGNDQSFTEYLAPDREKGTKMLRMDDRLWIYSPATDRTIQLSGHMLKQSVMGSDLSYEDMMDDRKLIEMYDAKVIDEEEVEGRSAWVLDLVAKVDDATYEQQKLWIDQERFVPLKEEMYAKSGQLLKRVTLSNVERIGDRWFPKKMNYKDVLKDGEGTDFIVKSIQINPEIPDYIFSKASLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV18</accession>
    <name>A0A654DV18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="188" mass="21495" checksum="419BB4D4CDF786FA" modified="2020-04-22" version="1">MDKLINYLLEFGQLNQQQINLIKRKAQVLELKKGDYFSEAGKIPRQVTFIEEGILRVCYYNSKGDEITKYFVDENNFAVDINSFTQKIPSSEYVQAVVYCTLLVFSTESLNDLSATIIQWDGIINKITEKALVEKVNKLSPMLAEDATTRYLNFLEKFPNLANRVPLSYLASYLGITQSSLSRIRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVG1</accession>
    <name>A0A654DVG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4753" checksum="5B1C878B52BF05F0" modified="2020-04-22" version="1">MFLWLIEGTKRFAFTYRSLDGDNLGKGGGYTTSKHYLSQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVI6</accession>
    <name>A0A654DVI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019534">
        <property type="entry name" value="DUF2452"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10504">
        <property type="entry name" value="DUF2452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="18155" checksum="AC46D304A37E2F5C" modified="2020-04-22" version="1">MQANKIDVSKIDLEKEREKITDFPGLIAFAHTVGSALIKPEDKGKIKGQALAAMHDQTDRQFRQVMDQMRVLMEQAHELKMRVKVSERIYQSTLNFTPVIHQVYHLYRRKDGSEFLSMIAPAEWGRKLPFEKHEASVRLLSDHTWEVLEDHLEDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVJ7</accession>
    <name>A0A654DVJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024882892" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="872"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1297" mass="137108" checksum="A4743FDC90C73B83" modified="2020-04-22" version="1">MMKKTLLTCLMVMALIFIARAQGPYEESLTIPVYDSGNSEMGMITSPANFSSVINTSGKRIFFIQPGDYTSLGTTALTGDGTASNPRWLIYYDPNNPTDYTTHPVDMDPSDYVTFGRINVEGAYWRLDRIRAIGDEPTRNPNVYLVDDYQVLNRCLIEKGGGGAGQIAIGGSGSGKGPANYSVVQHCVIRNTQISTNEDNHGIKFDVGDYNRIVHNEIYNFAGDGIQLGPDQPFKGTVIYDNDIYIDPSKYSSSVSEIPHENGIDIKNAGTSTSGDHILIKKNRFRNLSKVPGGTSPNDDQGAIDHSNDGTYKSYMLVEDNIFVDCRIPFNTRGGDKTDHYTIRRNLMYRAERFAFWFQKNTEHSHDIYLNTVIEVEEKFGDQEWFESRAYNTRIVGNVIIDGGGTLSDSPSGTISDYNAFYNSSGHSFEGSNSISYSTAAAANNTSYTFTMGMFTGPETIVIPNARPTTSSPHYNLTSGITFGSTSGVGYSSSDTYQQAWAGALAPSANGAIPTVSITSPANNATVDGTITVTASASDTDNDLAGVQFKLDGVDLGSEDTSSPYSVSWNTTGASEGNHVLTAVARDDNGNLGYSSSITVIVDNQVDVAPTVSISGPANNSTVSEMVTVSATASDTNGDLVGVQFKLDGVNLGAEDTSYPYSVVWNTSSVTNGSYALTAVARDAAGLSTTSSTINVTVDNVAPTCITLPNTNTWVNTSLANQTSGFTIEFDVTPNATVNSEIGLSDGDVSSANDVAAMIRFQSGKIHVRDNQGYPSTHITYIADEVYHIKMVVDLTNHTYDVFANADGDSPTQIGDDNAFHSNSSSITKIDRLPAVLKSTNSGYAVDICNIVINGNGSSSTPPVVALTAPGDNATVSGTVSITATASDGDSDLVGVQFKLNGSNIGSQDTSSPFSYSWNTTGVSNAVYTLTAVATDAAGNVTTSAARSVTVSNASGGSSPTVSITSPSNSATVSGTISITATASDPDSDLVGVQFKLDGNNLGSQDTSAPYSFSWDTNNASNGSHTLTAVATDAASNSTTSSSITVTVSNSGGSCVVLPNNNSWVNTSITSQSGDFTAEFDVTPSHNVHSRIGLSNGSSSHDNDVATMIRFKDGKIVARSGQGWPSTQIPFSAGETYHIKMVVDMTNYTYDVFANKIGDSPSQIASDNNLNGTPSAINNLAAILASTNSGYQVDICNISINSGSRVATEIAVEEVFKEETSVSVYPNPVADFLKISRTDLDLNGSYSIRSISGAVISSGELSGKLFNIKTGQLPSGVYILDLRLAGEEPKAVRIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ5</accession>
    <name>A0A654DVZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="275" mass="32564" checksum="80304AB4CB5D7BB2" modified="2020-04-22" version="1">MFSEQIHSMLSFILILFSCYFLEAQPTENEDPTANYKFRTGEHLDFKLSYGWFTVGKASLDIDDNFHSYKNEDCYKVEIKGETAGFLGVFTHVDDRWGAYVKKEDLLPMHAYRNIEEGKYVREERTYFDHAQGKVEVMRYDPRKEKRNPKRMYEIKGDVYDLMSSYLFLRNVEFEKYRKGDTIRIKTFYEDELYNFELVFNGKEEIDSKVGLLQAYKVNFLVPPSDIFPNEQGIVAWISADTNHLPLRIEAEMFFGKAYCDLTGYRNIKYGPDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW67</accession>
    <name>A0A654DW67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="147" mass="15648" checksum="3400F926C90665B7" modified="2020-04-22" version="1">MALPLIAPTAEPVASQIPTPAQRTLIAGTSIQIGGVSTPGFFSSLQEDPNLAIIGDQNAAYNCISWSHGVTNAWNNPPANPIAYYQALGLKSCTAGDVNKKVAVWFDANGVTTHAAIRKLVTINGQKVYSWTSKLGQSYCMRILLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWH5</accession>
    <name>A0A654DWH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="369" mass="42174" checksum="29299BFD1E2E3724" modified="2020-04-22" version="1">MNEKNHIPIVIGNCLPFRIIERDTDNWKPTLEEINSRKYDYVKLNRMSTFIDIGIAPFSLGIGYDGSLVLPATEDFRTKENSLDKFNQTLGILLLGGVYSESVQPDNISYGSLFFDGYIKIHGGSEGLVAGFHKSIRSKMVGTLDSIKLLNPKSISTKEIEEAYKEGKDIIENLPNLSPNMLLDGTSHYVRNQWSESLIFLWTSIEQLINQIWEKEVINTKIDGVIEGRTKFLKDFRTWTTSARVEALFQQDFIPIGVYKLLNLARKTRNDFIHNGKPLNKEKVENALEGLFQIISLIISNYESTEKLNGTLEVIKQNQRGNLFPKKTKLEDGEVTHWLEVPPIPGDSHWGDKEYEIIEELVLQPLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWN8</accession>
    <name>A0A654DWN8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024900614" description="Abhydrolase_3 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="277"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="495" mass="56164" checksum="6334A26F1D128CEC" modified="2020-04-22" version="1">MQKSLALLTLFLIHQFSFAQTSAEAIKDQYFAEQQVFARQIIKDIYSDFASFNAVDPIRFSATIDSLEGIFYAHLNKYSNQLDAAVIRDENVGIQYFFDKFLLEYPYHHQDYTGEQVSLPAEKQSRITGHAADLNNPDLLSNRDFRAYVQAVLTIDANEAIATGAYDQSDNQQLEAVWACINRRFSDSAVRDYWRAEYLMNHMDNYGVKNISPIYDEFVATCSQEEAIRKVKAAYEKYEHARAAHLIEIYKKVDGYELEMHLFLPDSQKFTGQRPTILYFHGGSWSEGKPDWFFGEGEEFAKRGWVAAAIEYRIKGRHGTLPFEAVKDAKSAVRWLRENAVKYKINPDEIVATGNSAGGHLALATVLAESWNEESDDLNFSAKPNALMVVSGVFDLTVDNSKWIVKTLNDKELVKEISPNHLIKDGLPPMLIIHGENDGNCLYSTAEYFVTASERLNNEVTFRTIEGAGHFIWFGRYGGKVAAIQSEYLNALGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX23</accession>
    <name>A0A654DX23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025356">
        <property type="entry name" value="DUF4260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14079">
        <property type="entry name" value="DUF4260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13993" checksum="681968EF7500085F" modified="2020-04-22" version="1">MKNLLKLEEVAMFGLSIYLFTLTSFSWWWYPALLLLPDIGMIGYAINTRVGALTYNFLHHKGIAVIILLAGWQFGNDVLSLSGIILFGHASMDRVFGYGLKYPDHFQHTSLGWMKPQSVPNDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX37</accession>
    <name>A0A654DX37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="451" mass="50717" checksum="E96DE6D85962B811" modified="2020-04-22" version="1">MKSFRLHVVIRVVLAVSFGLVAYYFGMLTPFWLMSAWMVLFFVVTIVSLIRYVEKSDRELSGFLMAIRQNDFTNTYPAARSRSNQLHRAFNVITGEFIKLRSEKESNFHFLKTVVEHSGVPLMAYTVDDEEVTLVNQSVKTLFGIPYFTKLGSLQRADPTLVETIRSLRTGDKVLVKVKINGEMMYLSIVTRELILQGRRNKVIAFHNINTELDQKEVESWQKLIRVMTHEIKNSVIPISTLAEVINDMLKGSGEGSFALGDLSPEDQDDLIVSIRTIEKRSKGLVKFVASYGDLARVPRPELQQVDLCELVREVVRLQEKPLRKAGIALETNFPKGALTLSLDGEMIQQVVINLVKNATEALKDANTPNGQIQLVIAKYASEVVVQVADNGPGIEEEILDQIFIPFFTTKKEGSGIGLSYSKQIMRAHNGNLRVKSTEAGAVFELSFWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE2</accession>
    <name>A0A654DXE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16524" checksum="B1D460D8FE459C9C" modified="2020-04-22" version="1">MKKLKCVLLIDDDKDCNFLQKRTILRSTWVEYVEVARNGEMALEILKKAKFTPELIFLDINMPKMNGWEFLNELKKIKDTFEKKIVVIMLSSSLNPDDRVLAETYDIVGGFQSKYLDEASLKQILVDHFPTRFDFQQKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXE6</accession>
    <name>A0A654DXE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="432" mass="48675" checksum="AE07E1D640A3621E" modified="2020-04-22" version="1">MIKGLFILIGMISFIQDPHLVMDEETAVSIALEKNFDLILESYQVVLAENDNTMGNAGMLPTIDLSGEARQSIQNTEQQFFSGDTQSRTAAKTTNYNAGVNMAWTLFDGLKMFATKERLEEIQKTNEYAFRAQVQNVLSDVMKAFYNTALEQERLALLQSTLALSEERVGISKEKYEVGKASKLEYLQAQVDYNTDQSALVRQQEVIARSKLALLQLLGLDTSDSLSLQYNYELNGLLALPELEETALQQNPDLQYLQSQREVAMLTTRERERELYPSLDFNLGYNYSNLKAEAGFLQSNRTNGVNYGLSATMTLFDGLNQQRAIQNSRIQSEYAMTAFEQAKMQLLTAIRSGFLTLKNSLTLVALEEQNLEVAKENVEIALERYRIGKSNPLEIREAQNNAVNAQIRHLEALNSAKIAEIELKRLSGQIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXH1</accession>
    <name>A0A654DXH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024816220" evidence="2">
        <location>
            <begin position="30"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="216"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="535"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="685"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="963" mass="108272" checksum="6F37FCDC2CF6B21C" modified="2020-04-22" version="1">MMKPLKQNHIMKKSLLLILISLASWSVLAQTKLIEEVTKTGDEIVIPYKKYQLDNGLTLIIHEDHSDPLVHVDVTYHVGSAREELQKSGFAHFFEHMMFQGSENVADEEHFKIVTESGGRLNGSTNRDRTNYYETVPSNQLATMLWLEADRMGFFLDSVTQKKFEVQRATVKNEKGQNYDNRPYGRWSEVTAGALYPYGHPYSWLTIGKLEDLDRVDVNDLKKFFMRWYGPNNATLTVGGDVNPTQVVAMVEKYFGVIPAGPAVEPMKLEPPVLKSDRYVSYVDSNIRFPAIMFTFPTVPAFHPDEAPLDCLAEILGTGKSSYFYKKFVLTQKAIQASTFHPASELSGEFTMFVLPFPGQTLSAFEQEMRAILDEFAKNGVSDDDITKFKASRESDLINGLASVSGKVSQLANYQTIYGDANAIKYDLDRYLNITKEDVMRVFNQYIYNKKGVIQSVIPDAETAPAQPDNYEIPTSGESVFPTTDYSGLSYSRPKGDKFDRSKRPELGPNPTIKVPDFWKEELANGIKVIGTQTDEIPVVEIQLTINGGHKMDAYDPKKSGLASLTAGLMNEATQNYTSEQIQEELRKIGSDISVYAGTSQTTISASTLVKNLDRTLELMDEVLKRPAFNQEDFDRLKNQQLEGIKAGQKNPGAIANLVFDRLLYGDEHIYSVPNSGIEETVAAITLEDVKNFYDNYYSPSVSELAIIGDIDRKTVLAKMEFLKSWEAKEVKIPELPKAKPSGKTTIYMVDKVDAPQSEIRIGYVTDMSYDATGDYFKSYLMNFPLGGAFNSRINLNLREDKGWTYGARGYFSSDDDPGPYTASAGVKANTTDSAVVEFMKEISNYRINGMTDSELAFMRSAIGQRDALDYETPGQKARFLRRINHYDLDKTFVDEQNKIIRNVSKKELNTLAKKYLKDDNFYILVVGDAATNRPKLAKLGYDIIDLNEKGDVIEDGKIDTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK6</accession>
    <name>A0A654DXK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22601" checksum="9EE3232FCD86F8FD" modified="2020-04-22" version="1">MKFDQLAIMEELMEYILQIGNLNQQQLNLVTRGAIEIDLQKDKYFSEAGKVPRQVGFVVGGVIRGCYYNKDGEEITRCFISENSLVVDYVNFEANTVSTEYLQACTDCKLIVFPKQHWDELSQIIVGWDNIKNKMVQLCMYQKSRKGPVVSQDATTRYLAFMENYPSLINRIPLTYVASYLGVTQQSLSRIRKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR7</accession>
    <name>A0A654DXR7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="436" mass="47282" checksum="4F0D113C260A19CC" modified="2020-04-22" version="1">MALVEMVMPKMGESVMEGTVLSWLKSVGDPIEEDESILEVATDKVDTEIPSTHAGVLKEILAQEGDVIEVGKPIALIETEAGAANTPTASAPSEETPIVKEAEKIMESAMATASAADIPAKSGDKFYSPLVRSIAKEEGISLSELERVNGTGKDGRITKQDILSYVSTKQAGKAPAPNTNGQSKPSVSRPAPQPMPVTVSGEDEIIQMDRMRKMIADRMLASKQIAPHVTSFVEADVTDMVFWRNRMKNIFKERDGQTLTFTPIIIEAIVKAIKDYPMINIQVDGDKIIKKKNVNIGMAVALPSGNLIVPVIHNADQLNLVGITKKVNDLARRARENQLKPDDLQGGTYTVSNVGSFGNVMGTPIIMQPQVGILALGAIQKKPAVIETPQGDFIGIRHKMFLSHSYDHRVVDGALGGMFVRRVADYLEGFDKDRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS4</accession>
    <name>A0A654DXS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="743"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111724" checksum="C67AAAB5BD684B8C" modified="2020-04-22" version="1">MLIGKKSQKGLSHYSNLLLSVICLGVIGSCQSRESLLVIRAPDASTLQTEAFDSVTNVEKLDEKILTKASHLYLGTPVTDLGFDERSYIERYLEAGGLVTFSCRDTIYNWGQITGFLESKTAQIQCEENPALGISFPDYSRAKTRVRPGMDRLVREVLVAPLREPMALVVTENSVVYWIERKGTINRYDPGTGQSEEIDKLEVYTGEEDGLLGMVLDPNYKENHWAYVFYSPPGDEPKQHVSRFCFTSEGFDRDSEKVIIEIPTQRDECCHSAGDLEFDREGNLYIATGDNTFSRASDGFTPLDERPGRSAFDSQKSSSNTMDKRGKILRIHPEKDGTYTIPEGNLFPQDTTEGLPEIYVMGARNPFTVAINQDKGWLYWGDVGPDGNVTSERGPTAHDEINFATRPGNYGWPYFNANNLAYADYDFETGELGPRFDPSAPRNTSVNNTGAVNLPPAVPAMVYYTFDETAQFPGVGKGSRSVGVGEVYDYDNTRRHGYEFPEYFHHKLFAFDWARDWIKVVSQDKEGNFLSIEPFLDQTTLASPIDMAFGPDGALYVLEYGIGYFTDNRDSKLIKLHFINGNRPPVARIAETVTNGALPLKLMLSAKESSDPDDRAQLAHSWQVTGPENFSLEGDLNEINLTKAGTYEVQLLTRDEHGATSTDQMQVIAGNTAPQVSIQFADNQSFYWPGRPVVYEVLVTDVEDGILGDGIAPDRVTVGLSKYNGSDNRAPASLAALDAENTKGLAPGLQLIQASDCKSCHKLDEQSIGPSFYQIAEKYDQDYIAIELLAKKIINGGSGVWGDGMMIGHPDFSMAAAKQIVDYIFSVNDPVEDEFESIGVKGRLSTTGMTDEHLRISASYTDDGNPGVDKLTGTIEKTLSIPVLQAEQADELIDLSIVGPVENGDARFVVNSGSNPTMVYRGVDLTNISSLSVAYFFSEANETVAPVEIALYLDTPDGPLAGKVGLNPVQSGREARMELNTSGTYDLYFILKSSEGAYQLGINEIKFSINPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW0</accession>
    <name>A0A654DXW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8406" checksum="426E9AF8FB0541CE" modified="2020-04-22" version="1">MMMNTQVRTITKADYHTEVRDLAKGEHLQSIACIEKIMEHAQKLKTNGPNTQLAEVRLQMLQEMLQIHQGLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY95</accession>
    <name>A0A654DY95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane receptor for ferrienterochelin and colicin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025062399" evidence="1">
        <location>
            <begin position="20"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="214"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="854" mass="96174" checksum="86F4DB5EB4B34059" modified="2020-04-22" version="1">MIKTLLVSLGLLSTMWVVGQSTDHMSLTTALNSYQERNEIKFSYDPELLEQIAMPKGLDTLSPANFIRFIENQYPLKVSQVQDAYYTIALTERLYSISISDSVDGKTIAPSQATVLVNGQPIASTVSANQLDFLYKPNPTDQVEIYALGYNRKPISFEQLINKKSVALSLHPQIIELRGVIIEDYLTKGINMNPSNQSISIKVSDLPLLPGETDGDIFASLAALPGITTPDNRPGNLFIRGSSTDQSLILFNDIPIYHRGHYYGTISPYNPKMVDDVKVYRNGFHPKMGGRVGGALEINSTDEPQKNLNAGLGSNTLYGMGYAKLPSKNKKTGFSVGARRSYPYSFSSPKLRSISQMVFAGSALLDSAGNLQEDIDVLFEDYVGKITHQVNDNNLLTLTSVYSRSDVAYKVSQKNSDESNRIENLGLNLKWKSVINSRLVSRFSATSSDYRFAFRNLITPPKSANLRLLEIYSTNELTDFRIREEFSLDMEQGNRLQFGVDYKYQNAYYDYQDIPVRDTIVQTRGADQYAHTASPFVNFEWNSSKKLYVQIGARANYYSKLNDLKVAPRIFINYFANKQLTVKGSAGWYYQYLSQVKVLEFSGGGFDNELWLLADNKDTRIINGFQSMTGAILNLKSWIIDLEGYYKTADNISYYSAGRFSSRGEFYFASHLMYGADLLIKKQLSSNASAWVGYSWAESKIMVDTISDTRFESQFSQPHVFYVGGSLQHGGWKFSLGWNYASGQYARSFRVSEAETSYYRFVNQLPPDAPRPIDSYTDLADRYPAVHTLNLSASYQLPKTEDRKWSSTFGISLINVYNQQNLTDKAVRAGRPTAFLVDRYAIGFAPNLMITVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB4</accession>
    <name>A0A654DYB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IX secretion system PorP/SprF family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019861">
        <property type="entry name" value="PorP/SprF_Bacteroidetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11751">
        <property type="entry name" value="PorP_SprF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03519">
        <property type="entry name" value="T9SS_PorP_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="359" mass="40574" checksum="2279403229B6FCAC" modified="2020-04-22" version="1">MTLNLIHFNSHQLRLFCRLSFLFVLVSLLSTNNLKAQDPQFSQYYAAPMYLNPGLVGISQIGRAGLNYRNQWPSIDANYVTYSFFIDYFFEDEFSALGLIVNTDQEGIAGLRSTNIGLQYAYQLNLTDTWTFRPGVEASYYFRDLNFDRLTFGDQFDNSGQVRPTTGETFDTGFSARFFDLAFGGILYNDKMWFGASMHHVLEPNQAVAGGDAPLPRKFSLHGGYKILFTELNKRARPQGKGRERSMTPSVNYKQQGSFKQLDVGLYFTLEPILLGAWYRGLPIDGFTSTKNSEAIISMIGINKNNLTIGYSFDYTISDLGIGSGGAHEISLIYAFDLSDPRKPSREVRQLRCPVPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYH0</accession>
    <name>A0A654DYH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="15872" checksum="47E7293A990054C2" modified="2020-04-22" version="1">MNTYTAFLHIHSAVRWIALALAIFVTVKSLMGLGGKSAFGKTDNIFAASFVGTMHLQLLLGLVLYFFLSPITESALSNFGGAMKNAELRFWAVEHASMMVLAVVVAQIGRSKSKKATDAAKKFKLQAIFFGAALLLMLGGIPWNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYI1</accession>
    <name>A0A654DYI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerotolerance regulator BatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="79"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="322" mass="36529" checksum="DD7173EE9B3EDCF2" modified="2020-04-22" version="1">MTWAYSIDTFEIVLIAIFALLYLLYVIRLLRIRASMRTPISKWLIKFTLRSVYFALMMVALLGPSFGDSTREIKSIGKDMFICVDLSQSMNAFDIQPTRLEKVKFELKNIVEAFSSDRIGLIMFSNEAYMQCPLTYDNNALNLFIQALTTDLVPNSGTDFGPPLKMALKKLTDEENTVARQKSKIIVLISDGEDFGEETDQITEEIESSGIKLFTLGVGTERGSKIMTRRGYKKNNQGEEVVSRINTKSLKKIASDTGGKYFEINDSKNDVDRLINSINDIEGELRDSKQVDTKSNKYFYFLMAALLLMLFDALISVKVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYK0</accession>
    <name>A0A654DYK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="28649" checksum="8327F8E34A10C130" modified="2020-04-22" version="1">MVQNKSILIMKNTAELLEKVIDFHGGADFWNQQQGLEAHLNIGGVTWPLKGHDDPLKDVQFKADLHQQKGIWKGIFSTNTSSEFSPLKVSLLDGDKVEESLFQPKDSFQGHTIETPWSKLQLVYFSSYATWNYLTTPFNFLMSGVQVKELEPREEGNEVLRRLEVIYPADFATHSRRQIFYYSEEGFLRRHDYWPEVLGGSSATQIVENYKSFSGIQTGTKRRIYILNEDGSYAKDPVLVSIDIKGLTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL5</accession>
    <name>A0A654DYL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrofolate synthase/folylpolyglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="428" mass="46947" checksum="7D7AB2F813907FE4" modified="2020-04-22" version="1">MNYQQALTYLYERLPMFQRVGAVAFKKDLGNTRRLLEALGDPQNSFKSVHIAGTNGKGSSAHALASILQSAGYKTGLYTSPHLKEFTERIRINGTEVSPEFVGQFVTEHQGLIEAINPSFFEVTVAMAFQYFASEAVDIAIIETGLGGRLDSTNVIDPLVSLITMIGYDHADLLGNTLPAIAGEKAGIIKPGRPVVIGADQPDLLPVFEAKAREVGAPLKIMRKMRVVTGEQGVFHQDFEVLETNKPPMTLRTDITANYFLKNIPGIWGVISELKGQGFDIDVEAIRSGFANIKTQTGLKGRWQMIRQKPLVVADVSHNEPGMAQLLDQVSLVPRKRLHLIIGMVRDKDISGVLNLLPKEATYYFTQSSVPRSLPASDLRMQAEAMGLPGKSFDNVNEALKEAEKNAHSDDFILICGSTFVVAEIDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL8</accession>
    <name>A0A654DYL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretion pathway protein GspE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="463" mass="52159" checksum="89878F26C6465E30" modified="2020-04-22" version="1">MLDQSAPISSNLIKELSTSIAWKYRVFPKMAEGRRLVLYADAQEPEMLARQLSVITGKEIHIEVADSEWIGSQLTRYYIRSGGDTVRSLNVNSDEFIGEMISEANELGCSDIHIEKYQDRSRIRMRLDGKLIERYELKKEKYHEYVNKIKIISNLDIAEKRLPQDGRILIKNAKGQYDIRVSVLPTLFGEKVVLRLLSSDASNLDIRQLGLNAGQIKLFLESISRPQGMVLISGPTGSGKTTTLYGALKYLNVPTTNILTIEDPIEYTLDGINQVQLNEKVGLDFATTLRTFLRQDPDIIMVGEIRDVDTARIAIRAAMTGHLVMSTLHTNSAIGIISRLMEMGIPEYLIADTLNVAVAQRLLRRLCPACKHRQSDLSQLPEILKNSQIDCYFTPVGCSECHGTGYKGRMAIYEMVNITETNKELIFSKPDQYSSENGSLMTSAIEQFEQGETSLEEIYTYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYM7</accession>
    <name>A0A654DYM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="13521" checksum="C4D2F4A242B3FB30" modified="2020-04-22" version="1">MKIMKYVLFVLSTVLLVGLFSFSPAQPELLPTKLRITVIDGLGNPAEGATVTIYLNEDDYRNSENPVAKAISDNKGRVTFKDLKPVPYFIDARKGDMNNDFEGVRTAALEEGKLNKVNTVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY1</accession>
    <name>A0A654DYY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024977597" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="21908" checksum="4035694B06C45327" modified="2020-04-22" version="1">MKIFKYITLAATLLLVSSAFAQDDIDPRRKQAIDSLALEKVKDLSKYISIIGDKKTQYSEAQRVMDRAEELFAPDSEMGVSSLSKEEISYYKVRQYFERLMALNYDKVSIKWYDIHYISDLEQQPDGTFVGVITIYQRFEGTSDDGMSYKDTTKKDITIYVKKKETQIAGRTIEFWDVLLGDVRVTETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ5</accession>
    <name>A0A654DZJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH dehydrogenase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_12096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="9">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="125"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="654" mass="71597" checksum="5EF67D0A394D8466" modified="2020-04-22" version="1">MTTSAIYIALVLIFPLLGGIITYLSGSKNAGRLSLIGMLPGAVMAGFLIYQSYEASVMVRWEWLPGYELGWAIDRISAVLIGLVYLVSLLVHLFSAHYLSHDRAIHRYFGKLGFFTSSMIGLLAADHFLVIFIFWELVGFSSYLLIGFWFEDKEKAVAARKAFMINRVADAGLLIGVILMITELNQPFLSSLTGGNSSLLVNLAGFGLMIGALGKSAQFPFSGWLPKAMAGPTPVSALIHAATMVAAGVYLLIRVVPFLSPMVLNATAVIGAVTAFMAAVSALTQHDIKKVLAYSTISQLGYMVMGIGAGAHESSLFHLWTHAFFKAGLFLAAGAVIHYLHTLKHDDSTFDAQDMRMMGGLRKVLPFTHIAFIICGLALSGLPLFSGFLSKEGILSEVWLWATGHSTQGYWLAYLVSDLAFITALLTPIYIGRQILLVFYGNPRTAIEKLPQMEPLGLVKVPLIVLSAGALWLANALNPLDANGWWLGSFVFGDTVGHGHGSIQIWTMILSIALAIGGLAISYIFFRPGSMRTLSYQMAQVPTKWYSRLIFEGWYLERVYEGLSKNYIRMAGAARVFDRKVIDWLVNAAGVSTVVFSKALAVIDREVVDGLVNFVAWLSRGVGGMFSKIQSGKVQNQLIWMMLLLLLLVLWSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZL6</accession>
    <name>A0A654DZL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025072599" evidence="3">
        <location>
            <begin position="26"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="4">
        <location>
            <begin position="482"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="698" mass="78667" checksum="7D119B83372F7CE6" modified="2020-04-22" version="1">MSHTSRLFSFFVFHLFVLASSVSTAADTPPTTARIDSLISLMETTACDQDSLTLLYYGAIKGSLSGYPRGALKALEQLGKMKYCTGDLDSAIYYYRRAAQIGLQHDLNAESVKLLNRLGFYFQTAGLLDSSSYYLNKGLLLAQEVGDSLYIGSSYVGIGILYQHKGQIDKALDAYFQALRIAEAIDDKPLIITAKLNVATIYYDHQPSKLKSSDFLELLDLTRIIGDQQREVSVLEWLGYLKADSSEFDEAVAYFNLGLKVNESVRDQNSEILLLQGISYAYNLAGDHEQSIATNNRVIELARSSGYELYLPSMYVNNVSNYLALGRYREAIQDGLLAVEAGKKSGQVELYYKVLQDMAMAYNYLNMPDKAFETQLEYTKLSKAILDAEKSRQLAEMQTKYETEGKQAEIELLSREAAIQKLQLSKQGYFLAGLIVLIVVIIGGGVLIYRQRQLKQQQAITDLELAETKKRLVVEQQYRASELKALRSQMNPHFVFNALNSIQEYIMFNEKKLAGKYLGKFADLMRIYLNHSQARAISVPEEVEALSLYLELEKLRFEDALTYEVIMEEGADDDEIKLPALLIQPYVENALKHGLLHKKTDRKLTVRFSYLEAEDMLRCEVIDNGIGRVKSAELNQSRNERHKPFATDAIKSRIELINFNSEKPVEERIEDLYDDAGKAAGTHVVISVPKGAIVDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM9</accession>
    <name>A0A654DZM9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="126"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="217"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="218"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="43337" checksum="414BDCBE0B11F08B" modified="2020-04-22" version="1">MEAPLFKINPDRNKPWNDLPDLPIHPNLYRTVDIMEQLGNTKSALGRLHGRSVAIPNQGILINTISLQEAKASSEIENIFTTDDELYQAYSEEGEDVHVKGAPKEVLRYREALWEGHRYLMAQGQFDQDYFIRLYRIIKQTNDGLRPPSAHIYIKQGGTGPNAGTAIYTPPRDKGIIEQKLQNLTDFVNDDEKYPIDPLIKMAIAHYQFEVIHPFRDGNGRAGRIFNINILTQKGLLDLPILFLSRYIINHKSEYYSLLAGVTQRGLWERWILYMLKAVETTANLTFNKVNDILAAKEGMMKAITDETKIRKPEQLVQMIFTQPLTKVSHLTDAKIYAEGTARNYLNQLCDLSILEKRTISGHHYYLNMELYRILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR0</accession>
    <name>A0A654DZR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ald</name>
        <name evidence="12" type="ORF">MARINOS108_120193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="10">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD16416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="39992" checksum="E11622100175D043" modified="2020-04-22" version="1">MIIGVPKEIKNNENRVAVTPAGVIELSKNGHQIYVQSTAGLGSGFADEQYEEAGATILPTIEETYAIAEMIMKVKEPIEPEYKLIKKDQLVFTYFHFASYEPLTKAMMASGAVCLAYETVEKPDRSLPLLVPMSEVAGRMSIQEGAKYLEKPMGGRGILLGGVPGVRPAKVLILGGGVVGTNAAKMAAGMGADVTIMDVSLPRLRYLDDVMPANVNTFMSNEFNIRELIRNHDLIVGAVLIPGAKAPHLITRDMLKEMNPGTVLVDVAVDQGGCIETCRPTTHQDPTYVIDGILHYCVANMPGAVPYTSTLALTNATLPYAIQLANKGWKKACQDNRELLLGLNVINGEIVYEGVAKAFNLPFAPAEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU9</accession>
    <name>A0A654DZU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019619">
        <property type="entry name" value="DUF2490"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10677">
        <property type="entry name" value="DUF2490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024787588" evidence="1">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="249" mass="29118" checksum="99D7F09E2B7D2673" modified="2020-04-22" version="1">MKNCLFFTVFILVSVLQVSAQRTVDHQNLYWVKYQAVIPLSEQWRLKPSIEDRRYFDGNRQHMWLFTLDADRKLKNGWMAGVGFTRWTILLPSDPDSEFEVTQGEWRPYEYLTHSSRLSERFTLSSRYLMEERIRKNVGVDPVSGAPVIQDGYFFHFRFRMKAQIEYRLTPADASIPVHLAVYDELLVQFGTDKIDNIFDQNRISGLLKVGVGKQTDVSLGYINWYQQAPSGSAYVQRNILTLLVNQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E000</accession>
    <name>A0A654E000_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014966">
        <property type="entry name" value="FRG-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08867">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00901">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FRG" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="222" mass="25492" checksum="E7038B9035038870" modified="2020-04-22" version="1">MKSTTISSFEELLKEFEKEKEGQNIVFRGVANSSYQLLTSLGRCEPVNGKSLEQLEKRLIKLFKESSVPYLEHKPANEMEWLAIAQHFGLPTRLLDWSYNPLVATYFAIESNPSEDAAIYILSGCSTIQDPQAFKPLTIDKVYKYRPPYISARIQNQAGLFTVHPHPDQAFEHDKLRRVIIPKGIKGVIKKTLFKYGINQRLIYPGLEGVSRDLKWLETKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E004</accession>
    <name>A0A654E004_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcrA</name>
        <name evidence="10" type="ORF">MARINOS108_120283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="297"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="757" mass="86400" checksum="8CBF8FF93AD48B18" modified="2020-04-22" version="1">MASEVQADYLNELNPPQREGVVNTEGPTMLIAGAGSGKTRVLTYRIAHLIQHHHVEPFSIMALTFTNKAAKEMRERIEKIVGNEARNLYMGTFHSVFARILRSEASRLGFPSNFTIYDTDDSKTLIRQIVKQMKLDDKLYKANVVLNRISAAKNRLVSWQDYLNNPIYAQDDADNMRPEMGKLYQTYVMRCFSADAMDFDDLLFNTNVLFQEHPDVLNKYQQRFKYLLIDEFQDTNISQYLIAKRLAAVRQNIAVVGDDAQSIYAFRGADIQNILNFERDYPDLKVIKLEQNYRSTKTIVNAANSVINKNTAQLQKNVWTDNDEGDLIELIKATSDNEEGKLIASAIFETKMQTQSSNAEFAILYRTNSQSRAMEEALRRNNLKYRVVGGLSFYQRKEIKDLIAYLRFIVNPNDEQAVRRSINLPKRGIGPGTIEKLVVVASEENQPLWNVMENAKSYLGGRGGNQVDEYVTLIKSFRLTAEKKDAYDTAALVAKNSGLLKELYADKTIEGMSRYENVQELLNAIKEFTDDKEREDKSLSAFLQEVTLLTDEDRSDSNEEAVTLMTIHMAKGLEFNHVYIVGMEEDLFPSQMMLSSRADLEEERRLFYVAITRAKKKLTLSYALNRYRFGRLKNCEPSRFLEEIDPRFIKVNKKFGSRAALSSAESYVTKNFVNNLKKDQNNRKFASAPKHKPSPDFQPSDTSGLHEGMRVEHAKFGFGKVTVIDAEGANKKAKVEFDTAGEKTLLLSFAKLRIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E039</accession>
    <name>A0A654E039_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="15367" checksum="76710AB2C9AFF754" modified="2020-04-22" version="1">MDDFLKKVIDGSEATPPESCLLTFDRNFPKAINIDWSEKEAKFEAIFYQEDIEYIAMFDQQGLLEKYTMYLTPDLLPVAIKTHMDQLGEIMNAVLINEGNQLLYEVIIRDANLKRYVLMVDQLGKVLEERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E080</accession>
    <name>A0A654E080_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23726" checksum="B499CCCE33C6D375" modified="2020-04-22" version="1">MATPYKVKESRIDDISLLEPEAIYSYADYLKWTFEERVELIKGKLFKMSPAPRRTHQEIDSRLHVEIGTFLKGKSCHLYSAPFDVRFPNLTNDPDDQTFTVVQPDLCVVCDPAKLDDAGCKGAPDLVVEILSPTTASKDLNEKYRLYEEHGVKEYWVVYPGENVLEIYELIDGKYISRGKFVREDQVRSNVLKGLVLNLEDVFEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E087</accession>
    <name>A0A654E087_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046219">
        <property type="entry name" value="DUF6252"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19765">
        <property type="entry name" value="DUF6252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="178" mass="19849" checksum="1D6446819B2BB462" modified="2020-04-22" version="1">MRVLIVCVLFISLGLCISCDLGLGIHEPTELEKLPPLTTTGENTFGCLVNGEAFVVTNTSRMSAIYQGINQRALSLSGEIDNSEVDENVSMFIGNTIKEGEKYQLDNATTHKGKYDNQIGNCIYETSSIFQGYIYIYISKLDSLDYLLAGTFEFDAYSKDCQDTVRITDGRFDMQYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0J4</accession>
    <name>A0A654E0J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="407" mass="45937" checksum="7F4151EF5A241CFD" modified="2020-04-22" version="1">MVMRISGGVLSYVLAISLLMSVGLSMLTLYVYYARMEQIHYLTRIRLQKNLASGIQMTLGEYDHFEYDRPYDFDLYGEEQDSISILRRAWGLLDQYRVTAYKGNQEVSRSYTLAHRPEDKGRSAVFLVDDGRPLSLVGDTRLIGDCYLPVSGVQSAYINRVGYTSDSLIYGTELKSEKKLPEVTLSDAFGRMEQLEGVQLEQDNDTLINSFEADLVEVKAGNAGVNKVYSGHVLITSQSRLIFDTLASTTDIVAYAPVIEFLSGFQGNGQFFATDTIIVHDNVKLTYPTVLATYNRNDLATIQTRGKCEITGWLLMDGSKDGFRRRVIYLEDGTQFRGMIYCNGMLETYGTVEGHVTVKRFLVNAQTGVYENYLFNATIDGTQLDTAFLALSQWFYKKESKVLKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M8</accession>
    <name>A0A654E0M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024913979" evidence="1">
        <location>
            <begin position="26"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="45003" checksum="94CD914C2847CDF3" modified="2020-04-22" version="1">MNHRKVRLCLAVSMLCLAGSVYSQSSPSFFLTFSRHQSAIFQSQNSFLNGDNGSEQRISQCAGYKGELGWQTRNASAENQLLHYPAFGFGYTSFRFPQTNELGSPFALYSFLDAPFIRTERFALKYMFRLGLSLNWKAEHPVLNPNNSVIGSARNLYINSGILLEYNVFRNTTLNLDLGSSHFSNGHRSSPNRGVNLLTGSVGVRYHFQDYQSLAARSIGEILEFDDRNELYFTFGTGVREQTFGYFELDKKVAFVNKNYRFYNLSVALQRQTGYLLKWGGGIDLMSNGAANAKLEQLQNGAWKKLEVPLGEKLQLGLFGSLEWVMKDFSILIQPGYRVIDQEKIRKVTRFYQHLGIKYHVQDFIIGMGIRSVNFSESEYVELNLGYRLFWYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T4</accession>
    <name>A0A654E0T4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_120437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="313"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="411" mass="44685" checksum="C1B85F1E79B2BF8F" modified="2020-04-22" version="1">MNIPYLSLRSILAKPLSSFLSWLLLAFGVTVVLLILLVSKELENEISKNTKGVDLVIGAKGSPLQLILANIFHVDFPTGNINLKEAAEVSHSRYIGEVIPLSLGDSYAGYRIVGTTDAYAALYGAELTMGEWFHEPMQVVVGALAAEKLNLRLGDTFESQHGLSEDGEAHESEPFVVVGIMSPSNTVLDKLILTGVASIWEVHGHEEVHESHEEDSLVSIDHWGLTVTQEQYEEEQITALLVKYRSPMGAVMLPRAINGESSMQAASPAFETARLFNIIGVGIQVLNILGVMIIAISAVSVFIALLNSLKDRKYDIAIMRSMGATRSQILLHILFEGLMITFVGAISGLLIAHGVVYAMASSLEGINPRTFYFINEEWIVLFGCLLIGFLASVIPAVLAYKTDISETLAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Y5</accession>
    <name>A0A654E0Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_M75 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14659">
        <property type="entry name" value="Imelysin-like_IPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034984">
        <property type="entry name" value="Imelysin-like_IPPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024927004" description="Peptidase_M75 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M75" evidence="3">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="39768" checksum="D0CB9EC91E47B7AA" modified="2020-04-22" version="1">MRLLTLVFLALAMLTSCTSDKDPFGKMNDFDQGQMLENLANNLIVPSYLGLRDHTKSLKEAIAAYRSAPTVETLTAAREALKSARLAWQQCSPYQFGPSESNGLAGILNIYPVDTLKINRNIQSGAYDLTTLANADARGFQTLGYLLYRPGLSDEELISATLAPDRLYADQVALLMEEASLTVYDQWAPEGGNYIGTFTSEDAYGVNVGSSVGKLINAMNLDFERNTRDGKIGIPVGIRSLGEPIFHACEAYYAGYSVELFKASIAAYYTLYKGAEDVGLDDYLQAIEATTTQNEDLSVRIDTQFKALIEAGNMLEDPLPAQIANDQVTVQAVFAEMQRLAVLFKTDMASSLGVVITYQDNDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E118</accession>
    <name>A0A654E118_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="420" mass="47846" checksum="FFE57DBA8A810091" modified="2020-04-22" version="1">MFYFYPMAGNQQATQVIDHLFRNEFGKAVAYLTGKFGPSHLSAAEDAVQDALMKAMQSWPFGTIPDNPTAWIIRVANNKLIDQLRRQQKVYYATQLPETPEAPPIISDDLFKDEMVKMMFACCNPAMSTEHQLILTLKILGGLSIREIASSLLKKEETIAKAYTRAKKKFKEENPTLEIPTAGEIQNRLVVVLKVLYLLFNEGYKCTEGDQLIRKELCEEAMRLNHILLDKPETNNEWTRAHMALMHYHVARFAARTDESGEAISLELQDRSKWDAQHIELGNRYLNTIPEGYHNEYFIQAAISGIHVNARSYEQTNWAGILTLYNHLYSLKPNPLIALYRIIPVAMTHGPEVALSELSKLENEPLLKHNHLLSATRAELYCQLADWPKAKTALHEAIQKAENDKEKAFLNRKLVSIPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E145</accession>
    <name>A0A654E145_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_140123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024847138" evidence="2">
        <location>
            <begin position="19"/>
            <end position="2819"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="580"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="1490"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="1755"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="2014"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="2532"/>
            <end position="2659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2819" mass="305796" checksum="D2D439F886121579" modified="2020-04-22" version="1">MALRTTLLLIILINSVYGYTQVTDNFSDGDFTNDPTWSGDDSYFVVTEENRLNSNGPSDAASVLHLSTVSSVMDYTIWEFLLDLNFNGTTSNFFRIYLTSDKLDLEDNPTGYFIQMGQTSADYIKLFRNDAGTVQEIAQGTTGFSSSIIGEVRIRVIRDVLGNWTIYADPNGAQDFQLEASVLDNTYTSTNYFGVYFQYSTTSRYDDFGFDDLVISQLEMDTVEVLSATEVVVYFNQPIDQTDAETTGSYTLPGYTVSSATQSSVSDSVVTLTLDGGTPLVTGDYTLTVTSALTRNSDATYDFSYTQLQLQSALTLSETEMLLTFNDDLEETSAETLTNYTIDNGIGQPAGVSLNEDRSQVTLTLSNSLYEGTTFELTLSGIQNETGNSVFAGTEDFTFVIPVVIDSAAAQSQSTVLVMFNKPLNETIAEDVLNYSLSGGLGNPISATLQDGSQSVELTFSENLADDNYVLTINDVEDLDGNIIAENSTISFSYLHLDIVSVVQIGDESVRITFNQEVDQATAEMVGNYSLSEMGSPTLASRSSEDLSEVTLTWDELYNSVYTLSITGISNLIQNSEPSELSAQLAISKASDYRQLLITEIMADPTPVVGLPDAEYVEIYNPGSFSINLEGFELNDEPLDSFILQPGAYALLTDDSNLATFGVTNGIAITSFDALTNSGETVYLRDQFGNLLDSVTYALSWYRSDAKDDGGYALELIDPLQPCSDSQNWIASVHSNGGTPGVQNSVFDDQDTSAPQLLSVTALSDDQLTLVFSEPMEASSVTTESFDLEGYAFTSVSAVSYTTFSLQLSADLISERSYTLTVSNVSDCRGNILTDQNISFYHDTRPPQFSRVQVLTSQTVALIFSEPLNEAIAEDEANYSITGYTVDQALLQDSATHRVHVSFNEEFELEANYSLTYSQLEDTLGNALVSANAFFEYQDQIDTAYVVAPNLLALRFTEALESTSATSFVNYWLEDAKSRPVEIALSESDPKLVHLAFGANFSENKDLRIFISNIKKSIDNSSLVTPAYTFKYDTRAATIASLLVKNDSQLIITWSEPMEVQTATTSSYYELEDDEQPIEILQLSDTEYELTFANHFEIEGQKRLSAKGMKDRYGVEVTTTRNVDFTYDPRPPSINMVRLIDPERLKISFSEKVSLGSATSLTNYTMEGENPLAAELLGPDSAKVVLTFSSIESKPEGQLIAIGLSDQVGNISDADTILVNTQNPNMVSLVPETDSSFVLTYSHSMNPVAFEKSSYSLDGFTIAEVSQRDDYSAVFTVDEKFTEGDSLKLTGDVIEGANNELVLSPFVSTRFTSYFEGYDLLDEQTLWVRFDTEFSSMSKTVFTIEGNSISLVNIDPEEPGSVRVLLSTPLEPNVPLMLEWAGISDKFGRRLPDYRLSVERDTQKPEVSDLESEYLGKLTLTFTEPMDESSLKAISNYRLLGKGHPAAITVVDDHSALLDFDNGLEVGVGYDLLILPISDVAGNYSVQDTVAFSYQPPAFPAYGDIVINELMIDPSPAVGLPEVEYIELFNASSQAYDLRGLKIGDPSVETILPAYVLDPESYVLIVATSSKSLFSGSNILGISGFPSLGNTGDHVLLKTIFGDLVDDVNYETSWYGDPLKDDGGFSLERIDPWGMCPEAINWQASTHSLGGSPGEENSGYRTGSDADLPMIEGFMALSTSQFQISFDEPMDSSSLLTMIITMTGFEIEERTVGGDYFTELTFSLSTPVALGETYELEVSGASDCSGNLMEPETITVGFGRAPVPGDLIITEIMSDPDPVVGLPNSEFIEVYNATDELISLSGVRLRDATSSTTLPDVNVPGGAYFILCPSTQVAAFSPYGLTVGVTSWPSLNNTGEALSLFKDVTIAAVTYSNDWYENSEKSDGGYSLELINPFGVCPGGANWSETTDPSGGTPGRQNSVYSLEPDSEVPVLKSYSTPDELTIRFTFSEPMDSASLMGATVEGVTLSSRVVTTADFDELQITLSDPLPKGSLVEITISGASDCSGNLMEPETISVGFGRAPVSGDLIITEIMADPDPVVGLPNSEFIEVYNATDELISLSGVRLRDATSSTTLPDVNVPGGTYFILCPSTQVAAFSSYGLTVGVTSWPSLNNTGEALSLFKDVTIAAVTYSNDWYQNSEKSDGGYSLELINPFGVCPGGANWSETNDPSGGTPGRQNSVYSLEPDSEAPIVISLEVLDETTIRFTFSESMDGESLLGADITGLSVSETRLVDQDFTILEVLLSSPLPKGVSVEVGLSGPSDCSGNPMTARTFVVGLGDIPGFNDLLITEIMADPEPVAGLPNSEYFELYNASDRLLTLKDVELHDATNTVTLPAVVIPPGGYWFFTPSSSLGLYGEVTNQSAVSGWATLNNTGESLSLWYGSQLVFQITYSDDWHDSDEKSGGGYSLEMKDLSNPCGGSLNWGSSMASAGGTPGQENSNKERVPDNFGPNLTGAFAIAADTVLLIFDEGLDPDVTASIELSFDPELSYHTSILNADRTEVKVALNGELKVNQSYGLTVMGVTDCNGNEIRKNTASLVLPDEAVADELILNEILFDPRPEGVDFVEVHNRSEKYIDLQGWGIGRLTEDLQTRWISQRYILKPGGFVAITTDSVIVKNQYPQGVNKQFLQISSLPTLPNDAGTVVLSSPTGEIVDQFSYEDDFHLSFLESVDGVSLERISADGLSQDANNWTSASSAAGYATPGYINSQAFEARTSNARVTIDPKVFVPGSANPAYQSFTTINYQFDKGGQFANITVYNQMGQPVAELARGTSLGTSGFVRWDGTTGAGDRVRMGYYVVFFELYDGSGSKQILKETVVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1F6</accession>
    <name>A0A654E1F6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="11430" checksum="9195674F9B2592B0" modified="2020-04-22" version="1">MSTLTASHLRIVHDLFHKLFYIKLRNSNAELRYVRHADQYLDFTATSVPREFRNLGIAGQLVEAGLIFAREQNMKVKTTCSYAADYVKRHPEYKDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I9</accession>
    <name>A0A654E1I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="11" type="ORF">MARINOS108_120480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD17097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="17863" checksum="23842D031AD88702" modified="2020-04-22" version="1">MSQSNIKAVKASEIDLKEKVVAIKRVAKVVKGGRRFSFSAIVVVGDGSGVVGYGLGKANEVTDAITKGVDDAKKNLVRVPLFKTTVPHEAIGKFGGGLVLLKPAAPGTGVIAGGAMRAVLESAGIHDVLAKSKGSSNPHNVVKATFDALNRMRDPYAVAKQRGVTLDKVFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J3</accession>
    <name>A0A654E1J3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024995133" evidence="2">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="217" mass="25495" checksum="752A8B14BA78D335" modified="2020-04-22" version="1">MKRAIILSVLSVILLASKSEAQQFRFVTSLGVQQHWEIPYEVYHSIEHEYRGFDLVHARRVPFRRGYTFELIMRRGDVFVVVDIERNGRIVRQVIDYNYPLYDHHCSTFCGFHTTYYASQSFHHYHHGPRYRPVAIHYQNYSQPKHGHGHYKYDKGHGKNHHKSNKVDYGVSRRESVKYSSNEGRSRLNAGTTQRSTSDRGDEQPTYKSRSGRSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Q3</accession>
    <name>A0A654E1Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="76" mass="8207" checksum="D2F19854DD50FF0B" modified="2020-04-22" version="1">MATVLLGIGFIAIFFILMSVRLIFKKNGEFKGTCASQSPFLNKEGATCGYCGKTMSGDENCGNPDSEVNKLMAKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D5</accession>
    <name>A0A654E2D5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-carbamoylputrescine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32976" checksum="03D04F3C1072511D" modified="2020-04-22" version="1">MPKERIVNIGLVQNACSGDRDQNLQKAIKGIEDAAAKGAQIVCLQELFGSLYFCDVEDYDNFNLAEAIPGPTTDIFCALAKRLGVVIVASLFEKRAQGLYHNTAAVIDADGTYLGKYRKMHIPDDPGYFEKFYFTPGDLGFKVFETKFAKIGVLICWDQWYPEAARITALMGAEMLFYPTAIGWHNSQDERTNQEQHNAWQTIQQSHAVANGIPVIGVNRTGVEGDMQFWGGSYVTNAFGWLEYKAPHLEEVTEVVPIDMNRSDSYRIHWPFLRDRRIDAYSPIEKRFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L7</accession>
    <name>A0A654E2L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_20161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014870">
        <property type="entry name" value="DUF1793"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032515">
        <property type="entry name" value="DUF4964"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="DUF4965"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="DUF5127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08760">
        <property type="entry name" value="DUF1793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16334">
        <property type="entry name" value="DUF4964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="DUF4965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4964" evidence="2">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5127" evidence="4">
        <location>
            <begin position="259"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4965" evidence="3">
        <location>
            <begin position="493"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1793" evidence="1">
        <location>
            <begin position="667"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="834" mass="92864" checksum="CA7DA7ED17651C82" modified="2020-04-22" version="1">MSSTFLNRLLVFAITGLVLTACSKPVEPPKEEAGLEFRAPAYPLITIDPYTSAWSTSDQLFDSPVKHWTGKNHSLIGAVRVDGKTYRFLGKEEIPLQPVLTNAKYEAWDGTYVNEAPAAGWEQPEFNDASWKSGKGGFGTPNTYHVKTDWSTREIWVRREFTLSDLGSGKLYLNYSHDDDFELYINGKEVVNTGNRAKQNITIALDKSLLNVNGKNVIAAHCLDRGGLAYVDFGIFKDSERKPVFGQVAQQTGVKMTATQTKYSFTCGPVDLLVEFVSPLVIDNLDLLSRPVNYINYQVVANDGQSHDVKVYLEATPEWAVNELNQEVTINSGKVGNVNFLKTGTTEQSVLGKKGDDVRIDWGHFYLASEQSASKTFAFGDFSEVKKIFSETGEIQPSGSETKAVLAQSMPVLAFTDDLESVSSSPVSGYVMLAYDDIESIQYFGDNLKAWWTKDGQVSFNQALTSAATGHDQTMTTCDELDAKIYQDARQAGGENYARLCVLSYRQSIAAHKLVKDTKGEILFLSKENFSNGSIGTVDVTYPSAPLFLAYNPELLKGMLNPIFYYSESGRWTKPFAAHDVGTYPQANGQTYGGDMPVEESGNMLILATAIANAEGDAKYAEQHWDVLTTWANYLLENGLDPENQLCTDDFAGHFAHNVNLSVKAIMGIAGYGKLAEMLGKEEIAEKYTAQARQMAQEWIKMADDGDHFKLTFDKEGTWSQKYNLVWDKLLNLGIFPAEVAQKEVAYYLTKQNEYGLPLDNRRTYTKADWVIWTATLANDQVTFQKFIDPVYDYVTETPDRVPMSDWYETPNAHQVGFQARSVVGGTFIKVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2M6</accession>
    <name>A0A654E2M6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14945" checksum="F795947079A27059" modified="2020-04-22" version="1">MTYQAKSIRAFIGARVFEESRQFYSLLGFEEVVIDASMSLFKVNDKLAFYLQDYYAKEWINNSMLFLEVDDLDRCRETLLKKNLPAKFHSVRFSEIRNEVWGRELFMHDPSGVLWHFGEFKEAPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2P8</accession>
    <name>A0A654E2P8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="292" mass="33061" checksum="A333FB1E6E514734" modified="2020-04-22" version="1">MKRLFFVVANPASGSTRLEDILNDVIDFLNDKKYKYEVFLTSKKHNAWKTVEKNFDPSFTDLLIIGGDGTINEAINGLKYDVPVSIIPNGTGNDFVKNYPVGKSIYDYLKVLDKGAIHTIDLGLCNGRKFVNGVGIGFDGQIVADMLRKKSFLKGPTKYYYYVLRILASYKARRYKFVQDKSTYEKNLILLCVANGTTFGGSFKLTPDAEINDTILDVCEIGKISGLRRFLNIHRLKEGTHDRLPEVKLSRCKHLTVDENPHLEAHIDGEYFGHPPFEFGVLPNALRIRMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V0</accession>
    <name>A0A654E2V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_12138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="624" mass="68978" checksum="4092E24EE6294044" modified="2020-04-22" version="1">MSKSFIFVILFFLIARGVVAQDPSGLSQRLDTLSKEIAGLNEPVDFTLVDAPLSELLRAVAETHHLNVNLGNIPQIAITNNFNNVLVKDLLLFICDEYDLQIKFTNNIFSFYHQGIVEPERAIATYDQEHQLLTINAQNNLLAEVAADITRKSGYNVIVNQAVAGQMVNAFIRALPIEVAIENFAEANNLKLEKKSENVYQVSGQIAPQIENNRPSRRSAGYTHSGGHDLKTFYMDGLPYLSINCYQTPAVELIRQVGEQLNIGYVLLGDPQGMLNCRLDSVSFEDFLNIALESSNQTYSVTNKGIYLIGEMQKGTINEARVYSFKNRSVEGVEAVIPQSLIQQVQVKPFNDLNALILTGSEQAINRLTSFLNDIDRAVPNVLIEVMVVEMRKGSSLRTGVKAFLGDSVPTTQGQIFSGVDVTLSSQTFNRILNNLDSRGIMNLGRVTPSFYATIQAMEENNNLNIRSTPKLSTLNGHEATLTIGQSVYYLIETQNVTGGVNPIVTVTPRYEKVEANLDLKISPFVSDMEDVTLSIEAEFSDFIPPEITGAPPGNASRKFISKIRVKNEEMVVIGGLEEVSKAEGGSGIPLLSRIPILKWLFSSKTKDNSETKLLIFIKPTIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2V6</accession>
    <name>A0A654E2V6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6089 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045743">
        <property type="entry name" value="DUF6089"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19573">
        <property type="entry name" value="DUF6089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024932739" description="DUF6089 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6089" evidence="2">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="235" mass="26738" checksum="B8065550E4965ED8" modified="2020-04-22" version="1">MGKYKLIFLFLLPLTLSAQFVEFGGGLGVSHYTGDLNGVPRLDHTNLAGSGIYRLNFSDIVSFKFAFTAGSISGDDSKPVDALGENRQYQFKHNFLELSGVFEYHFMSYRSEKYKNKWSPYAFFGLGFVKLNNTATAYEDYLRIQPVLPMGGGVKFLLSKRFTLAGELGARKTFFDYLDGISDGDQSIKNYQYGNPNDKDWYFYTGISLTYVLYKIPCPFPYIPNKSILNRIRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X3</accession>
    <name>A0A654E2X3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4,5-DOPA dioxygenase extradiol</fullName>
            <ecNumber evidence="6">1.13.11.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ygiD</name>
        <name evidence="6" type="ORF">MARINOS108_20433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.29" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050297">
        <property type="term" value="F:stizolobate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="31363" checksum="4239F5D8453D0F3D" modified="2020-04-22" version="1">MSSLKSFAKMTNDLPVQDKKMPVLFMGHGSPMNGIEDNEFTRKWESIAKEITQPAAVLCISAHWLTRGTHVTAMNHPKTIHDFGGFPQELFQVQYPAPGDPALAAETSKLIQSTNVGLDHDWGLDHGCWSVVKRMYPEANIPVLQLSIDYHQPPGYHYQLAQELSALRKKGVLILGSGNMVHNLRMVDWQHFEVPNYGFDWAQEMNEKFKTYIYSKEHSRLINYTELGPAAKLAIPTPDHYYPLLYALALQDQKEEVEIFNDQYVAGSLTMTSVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Y8</accession>
    <name>A0A654E2Y8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="32733" checksum="A01F1E50F45D34D3" modified="2020-04-22" version="1">MILMLVVVGAVAAQPASDLKEYLEAVRAGSYDPVPKSVLQATEAMPLLSVLATYEQDSIVRVRSRAYSIARRIGTKSQESEVRALVVGQLTRGIGDTDGGISGACSGGLTGFTPGDFDVTVKEQLKAFLLPATPHLDQVAMLVGYLVYDPATATLRGLLQERLSSTNKWSVRLALARMGDQESVDFILEKLRAANVSDNLVYDVVPGLVYTRDPAIFVFLEQIIQQDEPLCLSADPDSSQKILCGYRVMEYLAYAIEDFPIPTDEDGEVELDDYEAGLQTVRVWFDSHETYGFKMDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3K3</accession>
    <name>A0A654E3K3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025069528" evidence="1">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="481" mass="54442" checksum="8FA231AD4222201A" modified="2020-04-22" version="1">MLTFNKIISICCFVLLITMVACGDSGSNPGPDSKEELSLSERNLLRAMELTDSAISAHFSGAGMAMARYYNPYTDLRSDEIGSIWMYTSAIEAVNAILHSLERQKGGGNSKLYDEHFNRYTEVLSSLYENAKFYQGTFELVSYTQTKEWTIYGVNRGAGKGAASVAGIMNVYDDQMWFIRELVESYKLTGNDAYLQEAEYLTEYVLDGWDCTIDDNGEELGGITWGPGYVTKHSCSNGPMISPLVWLHEIYQGKSDQITHRYIDAQDKETRRTVQVTKSDYYLDFAKKIYAWQEERLLRSDGVYDDLMGGCSPGGPETETVNGKTYRKGIRCRDMAGPAITYNSGSMLSGAADLFRVTGDDQYRKDASNLSDASFEYFANPEQTKEGYYTWDISGFNNWFNGVLMRAYVDAYPEHKPVADYIDSFQKNLDYGYENFLYEGFLPTNLLVGWSQTNNNNRTEGMFNFAFAAEYAVLARYELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P9</accession>
    <name>A0A654E3P9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024823631" evidence="5">
        <location>
            <begin position="21"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="330"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="785" mass="87267" checksum="16911F02B225879C" modified="2020-04-22" version="1">MHMKFIATIIFLVAGTYVSAQSLTQTIKGRLVDQQSKSPIIGATVLVKDSEPMLGAVTDLEGYFRLPAVPIGRHVLIFSSVGYEVKTHPNVLVTSGKEVYMEVEMVESLVEMAAVEIVATNKQDKGQPMNEMATVSAISLSVEETSRYAATFDDPARAAATQAGVTTGGDDLLNEIVIRGNSPKGILWRLEGVEIPNPNHFNSVGSSAGGVSMLSANVLSSSDFFTGAFPAQYGNATSGIFDLNLRKGNFDKHEHSFQVGLLGIGMASEGPLSKNSNASYLINYRYSTLALFEHLGINILGDQEDITFQDLSFKVFVPTKKAGTFSLWGLGGANTYGYKADTVNTNDFYFEDESQWMGATGLTHIVYLGEDTYLKSIVSYSGNRNDYSEDSLRQQVWYTEDFTESQFRISSFLNHKFNARSTLRAGGIYSSLGFNLKSESWHRDQERFVTVLDEKGSTDLYQGFAQLQHRFTQDFSVNVGGHLTYFGLNNTTYVEPRAGMRWQVTPKGALTGGVGLHSRKESIALYLAREIRQDGSSTYNNKNLKFTRAAHAVIGYELMLKPDLKLKSEVYYQYLYDVPVWPNDTISDMEARTFSAINSYDGYTTVPLANKGTGRNYGVELTLEKYFTNNYYFMTTGSLYQSKYTAIDGIERNTVFNGNYIFNALGGKEYTFNNGQKVLSVNSRLIYAGGKRESPVDIEASRAAGYTIRDYTRTYEDKVPAYFRLDLGVSYKWNKIKSASVVAINVQNVLGIENVAFTYYGAETDKVWNATQLGMFPNLSYKVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E405</accession>
    <name>A0A654E405_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yjjK</name>
        <name evidence="7" type="synonym">ettA</name>
        <name evidence="10" type="ORF">MARINOS108_20945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="331"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="PtIM" evidence="7">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD19857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="559" mass="62715" checksum="E9660992A400C6BF" modified="2020-04-22" version="1">MSDEKIIFSMAGVNKIYPPKKQVLKNIYLSFFYGAKIGVLGLNGSGKSSLLRIIAGVDQDYQGEVVFSPGFSVGLLEQEPKLDPDKTVKEVISEAVTEVTELLKAYDEINMKFGDPEILDNPDKMNKLIEKQGEVQDKLDQMGAWELDSKLERAMDALRTPPEDAIIKNLSGGEKRRVALCRLLLQEPDVLLLDEPTNHLDAESVHWLEQHLQQYKGTVIAVTHDRYFLDNVAGWILELDRGEGIPWKGNYSSWLDQKQKRLAQEEKSESKRQKTLERELEWVRMTPKGRQAKAKARLSAYDKLLGEEGAQKESQLELYIPPGPRLGAKVIEANGVSKSYGDKLLFDNLTFSLPQGGIVGVVGPNGAGKTTLFNLITGREQPDAGTFEVGTTVKMAYVDQEHNDLKPDDTVFQAISGGNEIIHLGEKEMNARAYVSRFNFSGSDQTKKVGVLSGGERNRAHLAITLKQGANLVLLDEPTNDLDVNTLRALEEALENFAGCAVVISHDRWFLDRICTHILAYEGDSQVYWFEGNFTDYEENRKKRLGDQAPKRIKYRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E407</accession>
    <name>A0A654E407_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="284" mass="33573" checksum="8E50FFA72EF0FF0F" modified="2020-04-22" version="1">MKYGWIIILAFSYGCEFFKPKETATEAPIARSMESYLYPSDLDGLFPANISSDDSTKLAEKYIEDWIKKQLMISRSSQAVDFNEAEIERKVLDYRYALMVHSFEKKYITQNLDREVSTEQVTNYYNGKADNFLLKQNIVKCIFAQVPKNAPNLAQFRRNFRAHPEGNLEDLKSYVSQFATKSYLEDTTWIIFDELILGTPLETLENKNQFLSKNKYSETTNEEYIYFLNIFDFKISDEISPLEFIREDIKNIIINKRKIALKKELEEKIYDESKEQHLFEIYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E423</accession>
    <name>A0A654E423_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="17190" checksum="2E8F464A5A4F7E97" modified="2020-04-22" version="1">MFSLFSKKKKFKASCDLSGSPLERESAYLVSTAQIISSRKFWDNIMTEPDTMTYTEAYFKSGDQTATNIRGMIFKKYADKDRAWVISDSHLHLFDIDESAAKTVANDWWDSEGKEVPQELENSLANLDEHSFEEIKSYAVKEAGRRLVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E449</accession>
    <name>A0A654E449_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011622">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07696">
        <property type="entry name" value="7TMR-DISMED2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="529"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="614" mass="70000" checksum="A0CABED63E8D9E0E" modified="2020-04-22" version="1">MPSGITWSRKWGALIALFCGLGLSAQQVPLSTFEPNQAISINPYVEVYQTPDSLSAEEVIARIKNGDLKPAENKTSPGFSRDYFWIRFILTDDQSGDWVLELDNPHIDFVNLFEVKGDEGFLVGRGGDKQAFSYRTEINRRYVFSIEMTGQPREFLLMVDKRNASVSFPLRLWTEATFGANESMSNLLYGIYFGILAFVSAFSFVIGVGMRERNFLSYGIYVAIIAMYMFTQLGFSFQYLYPESSAFNNYSRVIFSFSLLITSMDFFSRLLDIRKYLPLLSKIYKIGWVFLGVVFVIWLLNRLFNPAYAQYTILTLNILYLFILGFFGSVFYVSIKTWRFQRGNVLLVMFAFFALMVGASIYILIEYGVISESFFPINPIIIGSMLEVLILSVSMAYRVKTLNERKNELSNKLLRQQKDLMRAFIRGGDMERKRISEELHDNIGSSLSLLKNSLANERFDPKIVNADIDALCEEVRTLSHRLVPHQMELIGFSEVLADYCKRYERDSGIKVALDQFDFPVLPEHMSVPLLRIVQEALQNILKHAQATEVEIQLVGYQEEIVITIDDNGVGFDPVQMAGGNGLINMQTRCELLHGHMDISSHEGKGTNILMTIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E475</accession>
    <name>A0A654E475_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="13743" checksum="7E775EDE438485E6" modified="2020-04-22" version="1">MRTNISSGSPWEDKVGYSRAVVIGNVIEISGTAPVKDGAPFYGSAYEQTRCCLEIIEATLKKAGASLQDVVRTRMYVTNISLWEEVGRAHGEFFSTIKPATTMVEVSALIDDKLVVEIEATAVISKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4H1</accession>
    <name>A0A654E4H1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="219"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="597"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="727" mass="82337" checksum="794A66A2620A2143" modified="2020-04-22" version="1">MSLWVVITIFFAYHLQFLKADFEFEKFFPLDDPDITFYENHLNHFGYDNDYLLIILENNNGVFRQDFLKKIAQLTASIKSEEGVIQVGSPLDFQQPIKAPLGVTLVPLIHLENPELYPQDSARMFAHPIYRYFFGIDGRSLLVQVTHQHFEDPVSADLLVNNLNQLLTQEHFDHFRLAGKLVAQKAFIGYIQSDFILFIASALVVSFLLLTLVFRSLKVSLMPYLISVTSLIWLLGLMALLGQTITILGSLIPPVILFVSTSDAIHLINAFRADEQPDFITRLKTAIHKVLTPTFLTSVTTAIGFFSLVTIDTEPIRFLGIFCGIGILLSFIITFAFGPLLIHQSYAPRKSGTATRYLAIWVIRHFRVVLAGTTLLVILSVAGLYLLKTDARLLDDLPADSEVRQDFEFVDIHYGGSKPWEMAYWPKDPNGSIWEEEVMREAHKIHQYLLKEYPMERLWSPVTFAMYGHQMINGGSSAAFEMPDTQNYHRAIRTIRPYTRKPEVPSLIGKNEHYARFTGFIPEYGSFETIRKDQELLSYLDAHINHDVIEYRLTGTTYLIDKSHGMLSANLMRGLLIAISVISLILGIYFRSLKILLISLIPNIIPLLATAGYMGLAGISLKLTTSIIFAVAFGIAVDDTIHFISVYRRQKARNRIYRMINTFQTAGKAMSITTLVIVSGFVLFLFSSFGATYYLGLFLSLSLTIALIIDLTLLPLLLHFTKNKNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K6</accession>
    <name>A0A654E4K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="105" mass="11452" checksum="5ED82E78E356037B" modified="2020-04-22" version="1">MLGLIVGFLAITVTTPITPQLNIEELAQVDNTPTEEEQQPETVLRAFDAIPVTAHVSLTHEFLLIDILPSFESLEEDITAGEEAVCAGSKVLKILFRRIISPNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T5</accession>
    <name>A0A654E4T5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">MARINOS108_20826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD19720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="224" mass="25031" checksum="82EAEB3AF8D7D52B" modified="2020-04-22" version="1">MRLDIITCLPELFDGPINQSIVKRAQQKGLVEIVIHNLRDYTTDKHNHVDDYAFGGGAGMVLMIEPIDKCISGLQSKNTYDEVIYLTPDGQTLNQGMANQLSLNENMILLCGHYKGVDQRVRDHFVTKEISIGDYVLSGGELAAMVLADSLIRLVPGVLNDESSALTDSFQDNLLAPPVYTRPADYKGWKVPEILTSGHEAKIEQWRHDEAVKRTQERRPDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U5</accession>
    <name>A0A654E4U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GyrI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GyrI-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25986" checksum="FCA542B580EEB57E" modified="2020-04-22" version="1">METLESKLDLTKADPLYYKAKVTPDLIHLGDYYYLTIAGQSAPEDPQFLQAIEAIYAVAYGIKFINKAEDNDFVVPKMECNWWIAGGLAQQHLFTQAPRSEWYWKISIRMPDMVASDHFFRAVHLAKTKKAHIKSLEDVKFESFEEGLCVQILHKGSWEDEQPSIGQLMDYVKANQLEITSYHKEIYLTDPKRVTPEKLKTILRYQVKRSGLHLNPIQANLKNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W4</accession>
    <name>A0A654E4W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate 2-dehydrogenase subunit 3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024835203" evidence="1">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="184" mass="20132" checksum="F9C0290891476472" modified="2020-04-22" version="1">MDRRKALINMSLSAAGISLSASLIAALGSCESKKQLSYQALTFSTDQDALLQELVELIIPTTDTPGAKAAGVNQYIDRVLAMVSDVPEKERFIAGLENMDRLSQKQFGNAFLKLSQKDQITLLQQMESEGRSTPGGSFFSLLKSMTIYGYYTSEIGASQELMYVHAAGVYDGDIPYAEVGKNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X5</accession>
    <name>A0A654E4X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">asnS</name>
        <name evidence="8" type="ORF">MARINOS108_20866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="136"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="482" mass="55140" checksum="536B40AE45CB14A0" modified="2020-04-22" version="1">MREKRTKIQEVLAREPIGEELTLMGWVRTKRASKNVAFIALNDGSTINNIQVVADVEQFGEEVLKKVTTGASIAATGKLVASQGAGQSCELIAESIEVFGEADPEKYPLQPKKHSLEFLREIAHLRLRTNTFSAIMRVRHSMAFAVHQFFNDKGFFYINTPIITSSDAEGAGEAFKVTNFELDAIPRNEEGGIDFKKDFFEKEANLTVSGQLEGELAAMALAEIYTFGPTFRAENSNTTRHLAEFWMIEPEMAFYDLKDNMDLAEEMLKYLVKYALDNCADDLAFLEKRAEEEDKNKPQTERAEMTLTERLKFVLENDFERVTYTEAIEILKRSKPNQKKKFQYLIEEWGADLQSEHERFLVEKHFKKPVILYNYPRDIKAFYMRQNDDGKTVGAMDILFPGIGEIIGGSQREERMDKLTERMKAMGIPVEEMSWYMDTRRFGSVPHSGYGLGFERMIQFVTGMGNIRDVIPFPRTPGNCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E530</accession>
    <name>A0A654E530_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ORF">MARINOS108_20724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="19777" checksum="9AFC3729B39CA8F6" modified="2020-04-22" version="1">MTGKKIALHGKPFELFLSEKEIASAIGRLAEEINRDFQGKEVVILGVLDGAFMLLADLLKKLEVSLTLELVKLKSYEGEQTTGVVKSLIGLSDELSGKHIVVVEDIIDTGITLKYLLGLLEEKKPASVSLATLLIKKEVFNDKFPVHYCGIAIPNRFVVGYGMDYDGHGRQLSQIYAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E540</accession>
    <name>A0A654E540_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">dtd</name>
        <name evidence="2" type="ORF">MARINOS108_20981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="16361" checksum="09A38EE15E0D747E" modified="2020-04-22" version="1">MIAVIQRVSEASVTISNKEVSRISDGLLILLGIEEADNNEDIDWLTKKVANLRIFSDEEEKMNLSLLDIGGEVLVVSQFTLHALTKKGNRPSYIRAASPDVAIPLYEAFVKKMESFGRPVLTGEFGGDMKVGLVNDGPVTIIIDTKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E544</accession>
    <name>A0A654E544_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ORF">MARINOS108_90153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="552" mass="61410" checksum="42462E1CCC359723" modified="2020-04-22" version="1">MIRSLSIKNYALIQSLEMSPSPNLNIITGETGAGKSIMLGAVGLLLGNRADTKALFSEEEKCVVEGVFDIKNYKLKELFEAVDLDFESECIIRREISPSGKSRAFINDTPVTLDVLKTLGVHLMDVHSQHESLHLGSNEYQLEILDIYAGHQELIAQYQKSYAEFTSAEKTYSRLVKKAQESAKDTDYKQYLYNELAEAQLSEGELELLEEELEILENAEEIKVNLGQLNQLLDESEISLINQLQEGLPLLSSIKGFSKRLEELFERLNSASIELQDIAREIANEQDRVELDPERLQVVKERIDLLFRLQQKHHTNEVTELIALRDELSAALEDVLNIDSEIKKAKAALEEAQKAMLSTGKALTASRQKHAQPFAEAIKALITKLGIENGNISIKITSTEPNINGLDLVELLFSANKGVQPRELKNVASGGEFSRLIFAVKYLLADKTAMPTIIFDEIDTGVSGEIALQMVNMMKQMAKNHQVVSISHLPQFAAGGDAHYFVYKDHSSDKSVSKIKKLQEEERVLAIAQMIGGEKPGASAMQSAKELLNPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E548</accession>
    <name>A0A654E548_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="35055" checksum="27C2460EF39938C4" modified="2020-04-22" version="1">MIKTGFCVSYDWEFLKNSLPRVYESSDVICLAIDKNRRSWSGEKYDIEDDKFYAFVESIDKDKKIILYEDDFSLSSLDSRGNCNRQRMMIANRLGIGGWHVQVDSDEYFLDFKGFTEYLIQLNPNPSGAEKPFNVLANWIPLIKKLDEGFLMVDFGGELPEMAPFATTCPNYERARHNGYFNRLSPFYVLHETWARGEAELWYKLNNWGHASEELSAQEQKMSYFEWWKSLNVSNYQMAQNVHPANPPEWPALTLEKGANIDELIDHMKAPIFPLSSFRLAVRNNRNIARIMHWIKWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D4</accession>
    <name>A0A654E5D4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045736">
        <property type="entry name" value="START_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19569">
        <property type="entry name" value="START_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="129" mass="15048" checksum="88B0E2143EBA7AA8" modified="2020-04-22" version="1">MPKEKFVGEYPINASKKMLYPYFSTASGLAQWFADDVNIDEDKIYTFLWDGDENKAKMVSSRTNSHVRFEFIEEDGDEDDPTYVEFKLDMNELTQEVFIRVTDYSDIDQEEVNDLYESLINDLKEIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5I6</accession>
    <name>A0A654E5I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+-dicarboxylate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_60076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="469" mass="50742" checksum="18D82F65E399DE4E" modified="2020-04-22" version="1">MKKLPLHVKIIIGLVLGIIWAFISSALGWNQFTIDWIDPFGQIFIRLLKFIAVPLVLFSIIDGVSGLNDTSKLGRMGAKTLGLYLVSTVTAITVGLLIVNFIAPGSHIDDAQRMKNRISYELWVQNTPGVEVKDGKNFLNDPAYADLVMEMSNGQELAAQQQTVEDKVALAKKQKEVPPLQFIVDMVPENIILSISDNKLMLQVIFFAIFFGITLAVVPNDKGAPVKNFISSINEVFLRMVDTIMAAAPFFVFALLAGVVAKMADSPAEVFQIFRGLGSYTITVLIGLGVMLFAFYPLVTSTFIKKISYKKFFKILSPAQFLAFSTSSSAATLPVTMECVEDGMGVSKNVSSFVLPIGATVNMDGTSLYLAIATVFLAQLHFVDLSLSQQLVIVLTATMGSIGTAAVPGASLVMLIIIIQTVGLNPAWIAIIFPVDRILDMTRTVANITGDATVATLIASSEGELRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5M7</accession>
    <name>A0A654E5M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TonB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_60116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
            <orientation evidence="1 9">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD20956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="227" mass="25348" checksum="B3EDF4ABA8E45E7E" modified="2020-04-22" version="1">MELKKNAAYDLEPKTPLFFSIGLVIALVLVTAAFEWRGQYEPLDLGSREPVWEQAYIVPNTVIPAPKPPEPMPVKKQQVITQPPIIVEGSELESYIEETEPIDDIPFDDIPIEPSPEVDNNVYMGELIETQASFPGGLSAFYEYVATNIKYPKRAKTMDVTGTVYVQFIIDKDGSLTELKTLKGIGLGCDEEAIRVLENSPKWNPGKQRGRAVKVRMVLPITFSLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5U5</accession>
    <name>A0A654E5U5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfotransfer_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_50002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="PTHR10605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="267" mass="31814" checksum="7D0DD533142555AE" modified="2020-04-22" version="1">MDFLKPFLLKLGYCSKPQFIIIGTQKGGTSGLFNILNQHSLLYGSSQKEVHYFDNDEWYEQNKLEEYHSYFPLPHQIPKGAKVFEASPLYLFHPKAAERLYSYNPKLKLIILLRNPVERAFSAWTMYHHHFSNQLSSRHDPRSFSQAIHYELNHLQTSDYYSDFRSYLKRGIYVNQIQNFLKFFPRKQLLAIESASLKNDFDPTIREILNFIGIPYAKLENITSNKSQINDKNQYQQEMKALHQFFEPFNKQLFDLLDTNWNWDYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5X5</accession>
    <name>A0A654E5X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase</fullName>
            <ecNumber evidence="5">5.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-keto-4-deoxyuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">DKI isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">kduI</name>
        <name evidence="6" type="ORF">MARINOS108_90015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate</text>
            <dbReference type="Rhea" id="RHEA:23896"/>
            <dbReference type="ChEBI" id="CHEBI:17117"/>
            <dbReference type="ChEBI" id="CHEBI:29071"/>
            <dbReference type="EC" id="5.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the KduI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008697">
        <property type="term" value="F:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00687">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007045">
        <property type="entry name" value="KduI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027449">
        <property type="entry name" value="KduI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38461">
        <property type="entry name" value="PTHR38461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006625">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="278" mass="31273" checksum="17377463428D7935" modified="2020-04-22" version="1">MNQIRFSTNPNDFLNYTTEDIRQEFLIPEVMQPGEITAVYSMYDRMVTIGVMPLKEAIKLPVYEDLTKAAYFLERRELGIINTGGEGVVVVDGESFTLANKECLYVGKGKKEITFASSNAATPAEFFVNSCPAHHEYPTVKAGLADANEVNLGTKENCNERTIYQFIHEGGIQSCQLVMGFTALKTGSIWNTFPPHTHLRRMEVYYYFDLADDQLVMHFMGDPQETRHIAIHNKQAVISPEWSIHSGAGTSNYSFIWAMAGENKAFTDMDGQDVKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E660</accession>
    <name>A0A654E660_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="179" mass="20574" checksum="E7EABAFCCB02E02C" modified="2020-04-22" version="1">MNVTLSRYFYLSLIILFLTIIIGSVYYMLGGFEEVKVYKLDPINRTVAGKMFITHYTDQAPIDFGTECREMVANGDIDGTLTIITFQNDTLPKNKIARFIGISLAAEMSEIPENFEVRQFQSNSRYAVFLSMHVLVQPRPHKIEAMLHAKAQEEGDELDDFFMEIRFPDNSLTVEGWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E686</accession>
    <name>A0A654E686_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, sugar porter (SP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="442" mass="48852" checksum="DC3E9A30AC003E55" modified="2020-04-22" version="1">MSRKLIMASLTASLAGFLFGFDTVVISGANLPLKELWNTSEWFHGTFIMSMALWGTVVGAMLAGIPTDRLGRKTTLIWVGVLYFVSALGSGLASDPYWFSFFRFIGGLGVGVSSIAVPTYISEISSASNRGRLGILYQFNLVFGILIAFISNYLLQGVGGDNDWRWMLGIEALPAFIYTLMVLGVPKSPRWLITHRNDYVGAEKVLKELSSSEAEASAMLKAIEEDHRKTKDDKSSVFSAKYKRSLILAFLIAFFNQLSGINFILYYAPEILQKAGFGSSDSLLSSISIGIVNLAFTFVGMVLIDKAGRKQLMYIGSIGYITSLFMVAYGFYVESSAIFKLIFILTFIASHAIGQGSVIWIFISEIFPNRVRAYGQAWGSGTHWVFAALITLFGAVLINTFAPWVAFVFFGCFMVLQLLYTHFMMPETKGKSLEDLEDLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6Q6</accession>
    <name>A0A654E6Q6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024841173" evidence="5">
        <location>
            <begin position="21"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="383"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="599" mass="68349" checksum="E6A6404240CE2DEA" modified="2020-04-22" version="1">MYRQLFFWTFLFLIPSLAMSQTWGQAQNSKTATLDVYWFTSVPFIYEEQGQLKGLEYDLLMEFTEYLKETRGVKLSIRWVEAESFHSILDIMKNPEKPNILGASAFSITEDRKQYLKFSEAYLPDITVLVTGQGTPIARTYQELKEMLDGRVAVTIKGTNYENLLRNLKDQLNIDFETLHIHSDQNILDNIAEDENRFGFIDLPIYLMLIKKGGDLTRQNLYNVRGTGYGVTMPKSSDWQTPFNQFLSDPRYHEKVGLIISRYLGAELYEFIENLYGGTEIGTSILTKEKELQLALIKNANLKLQKDRNVKRVLILGITFVSIFLGVIGFLFFKNRRNTRLLVMQKDQIEEQQNDIRQKNEQLMNRNMQLIALNEEKNVLMKVFAHDLRSPLGHIIGLSDFLNAHAEQMSEEDKELLTQIGTGAKRINQMISKILDVEVAEGARSIVLREQVDITQITQDIVSRYRAAAAQKSIEIESTHRHGDQTIETDHMLLFLVLENLVSNAVKFSNANTRVRLETDRQEGAVLFKVCDQGPGFSEEDRSLLFNRFQKLSAKPTGGEQSIGLGLSIVKKYVGDLGGKVWLETPNGTGSTFIVSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6U0</accession>
    <name>A0A654E6U0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="235"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="347" mass="40181" checksum="B2ABCE6B99FD40B6" modified="2020-04-22" version="1">MEPSLNTWTVIFLIAASQGIFLGVVIWTKRHQANGYLGAVVLAFSLMLLYYVLYWTGYFRLAPRWLGVLQGMTFLLGPLFYGYVRSDERLFRVGVWHFLPFVIYLIHFLVLPFESLELRRVLVRSVTVLQTIHLLIYAGVALRWTWVNALASGRWRIVLSLLFMGYAFSFLLYYVLVWTGLLKIEYDYFISVVAAVFIYSIGYKGYQGREVFHVNTGVKYDRSGLSQSAAEAFLAEVKRYMEEDKGYLNNDLKLQYMADELAISANHISQVVNELEGCNFTDFVNRYRVQEAKRLLQDEAHHYKIIQIAYLAGFNNKATFNSAFKKFVGVPPSQFKKALNRQHPQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E766</accession>
    <name>A0A654E766_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="379" mass="41133" checksum="D6E79C9AB8CF7292" modified="2020-04-22" version="1">MGMVGGGIGAFIGAVHRMAANLDGQIELVCGAFSSDAKRSAASGQALFLPENRVYASFEEMITKEKALPEGDRMDFVSIVTPNVMHFAPAMMALENGFPVIIDKPLAFTLEEAKALQAKVLETKLPFAVTYTYTGYPMVKQAMAMVRKGDIGKVRKVMVEYPQGWLSTKVEDTDQKQASWRADPARAGISNCFGDIGTHAANLAEYISGLEITEVLSEIRATVPGRILDDDANVLLHFENGANGVLSASQVASGEENDLKIRIYGDKGGLEWSQKDLNTLIVKDHGNPDKIYRTGGDRGGYLYEEAMQHTRTPSGHPEGYIEAFANIYRNFAEALRNYAEGKPADTVLDFPGIKEGVQGMALVKAVVASTKNGNVWTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8R8</accession>
    <name>A0A654E8R8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_110077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="39"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="535"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD15915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="669" mass="74592" checksum="2197B575B62702AC" modified="2020-04-22" version="1">MQIGSNFPSQLPEGPLADKWTNYKNHINLVNPANKRLIDVIVVGSGLAGGSASATLAELGYNVKTFCFQDSPRRAHSIAAQGGINAAKNYQGDGDSTYRLFYDTVKGGDYRSREANVYRLAEVSANIIDQCVAQGVPFARDYGGLLDNRSFGGVLVSRTFYAKGQTGQQLLLGAYSAMNRQIARGKIKMYNRHEMLELVMVDGKARGIIARDLVTGEIERHSAHAVVIASGGYGNVFFLSTNAMGSNVSATWKIHKKGAWFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKKKEDVEAIRAGKLKAKDLPEEDRDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNATGEAVYLDFAAAIERYGKEQAHLKGLDENDKKVVTDLGKEVIKSKYGNLFQMYEKIVDDNPYEMPMMIYPAVHYTMGGTWVDYNLMSTIPGCYVIGEANFSDHGANRLGASALMQGLADGYFVLPYTIGDYLSNDIRTGKIPTDTPEFDEAEKSVRDQLERLINNKGTKSVDYFHKKLGKVMWDKVGMARNAQGLKEAMVEIKEIREAFWKDVKIPGTLNEYNEELAKAGRVADFLELGELFAKDALHREESCGGHFREEHQTPEGEAKRNPEFQYAAAWEYKGEPGDAVLHKEELKYENIEVKERSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E984</accession>
    <name>A0A654E984_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperone protein htpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">htpG</name>
        <name evidence="6" type="ORF">MARINOS108_60024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="5">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="630" mass="72151" checksum="D80D028C6E6559AB" modified="2020-04-22" version="1">MQEKGTISIHTENIFPIIKKFLYSDHEIFLRELTSNAVDATQKIKRLASLGEYKGELGDLTIDVSVDKKKKTITISDKGIGMTADEIKKYINQIAFSGATEFVEKYKDKGDEQQIIGHFGLGFYSAFMVAKQVEIQTLSYQEGAEPAAWLCDGNTEFEIKTSKKKERGTDIILHIADDSEEFLEEHRIQGILDKYSKFLPVPIRFGQKDRQVEDGEDKDGKKKWKTVKEDNIINNPEPLWAKSPSELKDEDYLEFYKELYPFSEEPLFWIHLNVDYPFNLTGILYFPKLKKDFEVQRNKIQLYSRQVFITDEVKDIVPDFLQLLHGVIDSPDIPLNVSRSYLQSDSNVKKINGYITKKVADKLGDLFKKDRPSYEQKWSDIGVFVKYGMISEEKFEEKAKDFTLVKNVEGKFFNIEEYKTEVATNQTNKDKSVVFLYTTDEEKQHSYLETAKKRSYDVLVLDGPVDSHFINHVEQKYEGVTLKRVDADVIDKLIDKDEKKESVLSDAEKEKVSAAFKKAIGDDKNNVTVEPMATDDMPVTITLPEFIRRMRDMQAQGGGGPMMFGEMPLNLAVSVNANHAFTRKIVEAESEEDQIALAKQAYDWALLSQGMLSGKNLTNFINRSVELAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9N2</accession>
    <name>A0A654E9N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024906156" evidence="1">
        <location>
            <begin position="22"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="417" mass="46127" checksum="DD1709B01AFAD07D" modified="2020-04-22" version="1">MLNFSKLLLLTLLAFACAKPAEVKKAVADMTDEEVMAYATALAKQNIIVDGHVDLPYRMEVKGFMLKKKVEDVSVETEGNFDYPKAKEGGLDAPFMSIYIPSSYYVKGGAKAFADSLIEMTQNVATAFPDKFALANTPADIQANFDKGLISLPLGMENGAPIEDDLANVEYFFNKGIRYITLTHSIDNQISDSSYDTTYTWNGVSPFGEQVIAEMNRLGIMVDISHVTDSAFYDALRLSKAPLIASHSSCRKFTPGFHRNMSDQMIKDLAAKGGVIHINFGSTFLSKESRDKYDAMDSVMTNYRAETGLSRSDSAYKAFAKKYSEDNDVYADVKIVADHIDNVVEIAGIDFVGFGSDFDGVGDSLPKGLKDVSMFPNVIYELLKRGYTEEDIAKICYQNTFRVWNEVIKTAESIQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9U6</accession>
    <name>A0A654E9U6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked outer membrane protein, SusC/RagA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024880254" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="114"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="457"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115018" checksum="11F3D65C8576FA69" modified="2020-04-22" version="1">MMKKILTFLLLLTGMLASAQQKIISGTITDEETGEGLPGASVQIKGTSSGTITDVNGTFQLEASEADILVVSFIGYEPKEVKVGDRSVINLTLGFDVTALEEVVVVGYTSERRKDLTGSVAVVDLEEVKDLPPGNIMKNIQGRVPGVSITSDGSPGSGATVRIRGNGTLNNNDPLYIIDGVPSKAGMHEINPADIASIQVLKDAASASIYGARAANGVIIITTKRGKSKEAQIDFDASWSLQQYTTKLNPLNTYQRGKVFWQASVNAGLKPTSPIYNYSWNGDLNNPALGGITYNEYLDAKQTMRPADTDWFDEVSQPSVIQSYNLRISKGSENGSMMFSVGYFDNDGTIKESNFERINTRFNSSFSFLNDLITVGENFQVTYQEETQINAGEILFTSLVQHPIVPVHTEAGGWGGPVSGMTDRQNPVRLIEDNKQNRYKFVRPFGNAYVAINPVKNLQFKTNFGVDYSLFYNRSIRKRYVSGFLSEPDNMVANNTSVGGNWIWTNTATYDLNLQNQSLKFLAGTEQIKYAQEWFNASREGYISEDPNYAYLGAGAENQLNSGGGNRWALMSFFGKFDYSLQDKYLASFTIRRDGSSRFGANNRYGNFPAASVGWRLSNEEFFKSLIATPVDIKLRASWGQNGNQEIDPLAVYNIYRPVYGKEDAIWDNPNPPSYRPALGTAYDIAGADMGELPSGYITNQQANDNLKWETTTQWDFGMDYVLRKFSGSVDYFIKETSDILYFRTLLSAVGEASGQFVNGGTIRNQGLEAILTYEDHIGKLAFDVSGNVASLTNEVVSMPESLFIRTPLSGAVPNDAKIELLGETLVGRSVNSIYGYVADGLFQTQGEVDSHASQPGKGLGRIRYKDLNGDNVINNEDQTFIGVADPALSYGLNINATYGNFSFTVFAQGVTGIEYYNSYKTYTDFASLWPGTNWGERTLDAWSPTNQDSDIPRLTIVDNNNEGRVSTYFIENASYLKLRNLQIGYSLPQSTLDRLGMRKARVFVQGQNLLTLKSKGFTAPDPENPNYAFPIPTIYTAGLSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECD2</accession>
    <name>A0A654ECD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024800272" evidence="5">
        <location>
            <begin position="20"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="293"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="791" mass="89059" checksum="F7C538B4BF72C4E1" modified="2020-04-22" version="1">MKKLILTLLSGVLLLSASGQEKFTISGYVKDQSDGETLIGATVLIRELSSGNITNVYGFYSITIPPGEYSVEYRYVGYQPIQKTVSLNQNVRLDVELLSTEQKLEEVVVTAKPEDENVSGMEMSTAELDITTIQKIPAFLGEVDVVKSLQLLPGVTTVGEGASGFNVRGGSVGQNLILLDEAPVYNSSHMFGFFSVFNPDAVKDVKLYKGGIPAEYGGRLSSILDVRMKEGNIKNYEVNGGVGTIFSRFAVEGPIAKNKSSFILAGRRSYIDVLAQPFLKNNDLDGVGLRFYDLTGKTNYYISDKDRIYLSGYLGRDVFKFDANQGFDWGNKTASLRWNHLFNDRIFSNTTLFLSDYDYSFQVGETKDDLFSWKSRILTYNFKEQFSYFINTSNELSFGAEAILYRFKPAEVLGVSDGEESDISLDERKSIETAIYLGNTQKVNDRLSLQYGVRLSGFQYLGAGSIYYYEDAEVKGERRPVSSIEQADNWETIQFYSNLEPRFSFKYSVNPSTSIKGSYNRMSQYIHLVSNTTASLPTDVWTPSTNNIKPQLADQVALGVFKNFLNNQLETSVEVYYKESQNQVDYIDGAEILINRFLEGDLLSGDGRAYGAEFFVKKNSGKINGWVSYTLARTELKVEGINEGDWYPTRFDQTHNVKVTANYDWSEKWSVSANFTYITGTPYTLPSYRYENQGYTIPGVLGRNNGRIPDYHRLDLSATWYMRTLKSDGSPKKLQDHWVFTVYNVYARRNPFSIYFAQTDDLSVAGQAITQANQVSILGTFVPAVSYNFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDQ9</accession>
    <name>A0A654EDQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent Clp protease adaptor protein ClpS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="96" mass="10848" checksum="8C2B37B286A40826" modified="2020-04-22" version="1">MVQMEFAPEIEELVDVETDLGQGDIKDLIVHNDDHNTFDHVINTLIKVCKHEVHQAEQCTYIIHFKGKCAVKKGSFRELKPMKEGINDAGISATIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSF8</accession>
    <name>A0A654DSF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglA</name>
        <name evidence="3" type="ORF">MARINOS108_10016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.73" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042972">
        <property type="term" value="F:licheninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="44"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="31627" checksum="6BF3C3642A9DE54D" modified="2020-04-22" version="1">MINLLKWIPGVLITSLTLYSCSQVKSGSLSEQPEEKRLELVWEDDFTDPVLDDEKWTATIGDGCPDFCGFGNNELQYYSDREKNLRIEDGKLIIQALKDTLGNGGYSSAKIVTKGKGDWKYGKVLVRAKVPYGRGTWPAIWMLPTMDGERKWPLDGEIDIMEHVGYNQGMIYGTIHSKKYNHLIGTQKVDSIALPDAHETFHDYGFEWSEESMTWSIDSEPYYTIHKGDEGYEGWPFDQPFHLIFNLAVGGNWGGKYGIEDSIWPQTLEIDFVKIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSH9</accession>
    <name>A0A654DSH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025380">
        <property type="entry name" value="DUF4369"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14289">
        <property type="entry name" value="DUF4369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="232"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="41202" checksum="FB35F9354D0E8414" modified="2020-04-22" version="1">MSQSKYLVLGLILSVFGCGKSGEDGINVSGKVENPIKGELVVLNQFEFTGLKPIDTIEVDPSGAFEFYVKPAEATFYRLNFYNRQQMNLVLDGTEEEVVIMLEGNNPGGEVSVTGSKHTKYVQQLEGMMRDQQADVKELNQQAIEARMADDQQTLARLTEEYFALMKLRQKELKTFIWKIAPSLAAYYGLESLPVEEHFPFYDSVAQKFSAELPGNMFTEELTKKVSALRKLAIGAEAPEISLPNPDGEVVTLSSLRGKYVLVDFWAAWCKPCRAENPNVVRLYQQYQGENFEILGVSLDRNKAAWVGAIEQDGLPWVHVSDLKYFNSVAAAEYQITSIPATYLIGPDGKIIAKGLRGASLEAKLKEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSK7</accession>
    <name>A0A654DSK7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TrkA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="8">
        <location>
            <begin position="209"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="598" mass="65761" checksum="1132F962E424A64E" modified="2020-04-22" version="1">MGIDAIIVLIVIVVAIVLFATEWLSIDLVAILIMMALTMSGVISAEEGLAGFSNPATITVAFMFVLSYALLKTGSLQRIGPYLGPIFKRNFNLGILIMMVFIGIVSAFVNNTPIVAMFIPVMVSIGKISGISPSKLLIPLSYASIFGGMCTLIGTSTNVLVSGIAEKSGLEPFSMFLSAPIGITFLLVGSIYIYFFGKRLLPDRISESDPSERFAVRDYLTEIEILKDSEFVGQRIMDSILAKDLEIDVIEVRRNGNLFTLPAGDFEIKSGDILKIRCDVEKIKALKDRLKVSFNTSALRINENELQKGDTSILELIITSGSEFVGKNLREMDFRRRYRAVPLAILHSEKVVHENLHSVILNAGDIILTEIKMHRVQSLKREEMSQNSPFIVLSEEGIIDFNRKKFITVLSVIAGVVALASFNVLPIAISTILGAMVLVLSKTINMRELYASIEWKIIFLLAGALSLGVAMHNSGLADMIASVFVDQLGGWGPIAIVSCMYFITSMLTEIMSNNAAAALIAPIAITTADKLELSPYPFLIAVMIAASASFMTPIGYHTNTMVYTAGQYKFRDFFRIGLWLNILFWILATFLIPLFYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSL7</accession>
    <name>A0A654DSL7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="2">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pcm</name>
        <name evidence="3" type="ORF">MARINOS108_10057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="207" mass="23221" checksum="F7ABB9E6900C2385" modified="2020-04-22" version="1">MRKLLIKEVASKGITDERVLNAMMKLPRHFFFDEIFVTHAYEDKAFPIGQGQTISQPYTVAFQTELLEIKAGDKILEIGTGSGYQASILLELGAEVHTIEYNKVLYNQTRKFLPRLGYRPHFYQGDGSRGLPAQAPFDGIIVTAGAPSVPQDLIQQLKIGGKLIIPVGDGKTQEMYKFTKVTENKISKKSFKNFSFVPLLGEHGWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT10</accession>
    <name>A0A654DT10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleiotropic regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">degT</name>
        <name evidence="4" type="ORF">MARINOS108_10158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="364" mass="40627" checksum="01C4E939EE5BC5D4" modified="2020-04-22" version="1">MKIPFFDLKGQYSQIKHEVDAEIQKVLSTGLFMGGVPVLDFENAFSKFLGAEHCVSCANGTDALEVALKALGIGKGDEVLVPANSWVSTAEAVNNVGAEPVFVDVIDREHTIDPYLIEGAVNENTRAIIAVHLYGLPARMDEILPIAKKYHLKVIEDCAQAHGAKLKGRSVGTFGEVSTFSFYPTKNLGAYGDAGAIITNDTLLAEKMRRIANHGQLKKHDHDLIGRTSRLDTLQAAILTIKLNYLDQWVQKRNLIANWYDAYLGEGIVRPMSTTNFYHAFHLYVIRSKHRVKLMKLFDELGIGYGIHYPVPLPYIKSYLYKGYHQEQFPAATLLSKEIISLPLYPELSEQEVKYICNQVNTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT99</accession>
    <name>A0A654DT99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="135" mass="15421" checksum="B6A634A3F9B76C13" modified="2020-04-22" version="1">MLSNEEQLSILVHLSMADKFLAEEESKLIHKIGERCGLSREEVELIIDNPRPIPNLKNLPPDEKFTYLFDVIQLMKVDGKIYQSEIQFCERLALALGYKPGVVADLSAYIYSDPSISTKRSYLRSIADQHLIPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTU8</accession>
    <name>A0A654DTU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22304" checksum="C4EC1F6055E463AD" modified="2020-04-22" version="1">MILEAKEAKTQYDILREIKDRWSPRAFAPEPIDTKTLNTLFEAMRWASSSMNEQPWRVIYAHKGEEAHTKIVDALMPGNQIWAEQAPVLMVNLVKKTYTRNGAPNKSAHHDLGLAIGNLALQATAEGIGLHQMGGFHKTQLEELFDLPEDYEAVTVIALGYFGDPDQLPEALRNRELEERNRMPIDEFVHHGQFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTY1</accession>
    <name>A0A654DTY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="115" mass="13089" checksum="4BC5C9B34B1F8BDD" modified="2020-04-22" version="1">MTKTEIAKAFSNGEFEKTYDFIAKDAEWIVVEEDKFSGKQAIIDNCEQVGNYFKSVTIDFKTLNIITDGNKVVINGTAEFLRDGKRVSFVSACDVYEFNEDSQIQRITSYCIQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU69</accession>
    <name>A0A654DU69_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="13">PRA-CH</shortName>
                <ecNumber evidence="13">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="13">PRA-PH</shortName>
                <ecNumber evidence="13">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">hisI</name>
        <name evidence="13" type="synonym">hisIE</name>
        <name evidence="15" type="ORF">MARINOS108_10263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="13"/>
    <dbReference type="EC" id="3.6.1.31" evidence="13"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="14">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="13">
        <location>
            <begin position="109"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD10847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="22183" checksum="0607816D5DAAC73E" modified="2020-04-22" version="1">MALDFQKGDGLIPAVIQDDQTGKVLMLGYMNEEALAQTRQTGQVTFFSRSKGRLWVKGETSGNFLEVREILEDCDGDTLLIKALPKGPVCHTGSDTCFDEVNSNPITFLNHLRDIIEDRKKNPSDKSYTASLFKEGINKVAQKVGEEAVEVVIEAKDDNAELFLNESADLLFHLMALLSYKDFSLDDVVKILKTRHQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUG4</accession>
    <name>A0A654DUG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="4925" checksum="74761EA276FEF6C2" modified="2020-04-22" version="1">MLAFYQIYQFLAPEQTIVSYRGGYPEDEGFAVNYQMGLLDTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP3</accession>
    <name>A0A654DUP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="23254" checksum="DC7D74162B64CA3C" modified="2020-04-22" version="1">MISDEQVDFIAEEIRKANVKNEALRDDLIDHMCCLVEIDMDRGVPFDEAYQRAYHQTSPNGYGEIQQETVFLLNYNKIMNMKRLTYISGFTFTLSLTAGVFLKLLHFPGAPALLAIGMCGILFVFLPMLIVLRYKQLAVQVLSERLKWIFGVLSFVLFMVASWMKLTHLMGAGVMLGLSFFVFGFGFLPFLFFRMYKASIEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP6</accession>
    <name>A0A654DUP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="219" mass="24608" checksum="EA521F2E0F0204B3" modified="2020-04-22" version="1">MEKYSALGFVSLNQTQKRMLMYLKMHGAQPAAVLAGEMGLTNEGARQHLMRMMEEGWISSESQSKGVGRPIILYKITAAGFGLFPDAHAELTLQLLTSVKALFGQEGLDRLIQSREQETLKQYQSGVEGMGRLEDRLDYLVSIRSAEGYMAEWYQDGDLYFLVENHCPICAAATRCQGFCQAELQNFRQTLGEGVKVERVEHIVQGARRCAYQITTLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUX2</accession>
    <name>A0A654DUX2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14495" checksum="3D07B688C358FBE0" modified="2020-04-22" version="1">MKVEHLAIWVGDLEAIKSFYVKYFGAIASDLYHNPKKNFKSYFLTFADGDTRLELMQQPDHHQKGISTQLGWAHMALSLGSREAVDEYTERFRRAGITIHSEPRTTGDGYYESVILDPEGNIIELTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV93</accession>
    <name>A0A654DV93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized isochorismatase family protein HVO_2328</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="198" mass="21492" checksum="9D45282FB819E03F" modified="2020-04-22" version="1">MNTPTNTPGPALLLIDIQSAFDDLAYWGGERNNPEAEQRASELLQLWRARRLPVFHIKHCSTTPGSPLHPSHPGNAIHPLVAPLDGEPVIEKNVNSAFIGTDLQQRLESSHITKLVIVGLTTDHCVSTTTRMAGNLGFDTTLVDDATATFCKQGKDGQLFSAQLIHDTAIASLNGEFAHIATTAEVLEQWKDPEVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVC8</accession>
    <name>A0A654DVC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="12503" checksum="2EC0E284C87EA378" modified="2020-04-22" version="1">MNFIVRLLLSALAVIIVSHLLPGVYVEGFLAAVILALVLSLLNLTIKPILILLTIPLTVFTLGLFLLVINALIILIADAIIPGFEVAGFWWALLFSLLLSLTNALLTDLSGAKRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVF7</accession>
    <name>A0A654DVF7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024826845" description="PKD domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="537"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="665" mass="73673" checksum="99D874B418171EC8" modified="2020-04-22" version="1">MKNLLIVTLIAASSSAYAQFPCENGMSDGTYPCNQITLMGHLAPEEIDAVEHHGNYLNDIWGWTDAESGSEYALVGLVDGVAFVDVTVPTNPVYLGKLQESATSNGRVSRIGDVQHGKSSWRDIKTFKNHAFIVSDVNGAHGMQVLDLTKLRGLDGSTTVKFKADAQYEEFGSAHNIVINEETGFAYVVGVSDGGTKCSGGLHVIDINDPKNPAFVACFSTDGYTHDAQCVIYQGPDADYQGQEICFNSNEDTFTIVNVDDKDNMSMISRTGYDQVSYTHQGWLSEDHRFFLSNDELDENAFGFNPRTLIWNIEDLDAPVLIGEYYNNAAAIDHNLYTHNGLAFESNYFSGLRVLDLAQVADGKLRERAFFDTYPDADAIEFGGTWSNYPYFESGTIIVSDMNNGLFVLQLDLEEDIIATHPADMEGCENEELSFVVAATGTTNSYQWQRFDGKTYVNLTNNDQVSGAQTNELKIMAQNNYQGDILRCKITETNGTIHYTFPTSYEIKGEPLEVAFSFEETTPGSVQFTNESTGAQSYSWDFGDGSTSDEENPIHTFEYGVFNVTLTVTNECETAELTKETFVVTGLDDESKYFNVFPNPSSDLVNVFSQESGMLEIRDTSGKLTHEQTITRGAHAIGLNHLRKGIYFISIRTPETFVVKKLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL8</accession>
    <name>A0A654DVL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis PhzC/PhzF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="262" mass="29314" checksum="94D1BE8D0A32585B" modified="2020-04-22" version="1">MDELKFSTYAVFSNKDNGLIGNTSTVVETEHALSNVQMQSIASDLWQPATTFLWKKNDQWHVRWFAPDQEIGLCGHGSLAAVAHLYEKGILDTEIHFQNGIISGGVENEKCYITLASIPVIDELTIENYLLDGLKIPILGHFKTSNKNIILTDSQESVRFMSPNFEILRRSPIFGYAVTSVGDDCDFVSRTLVPHVHQLEDPATGSSHAALAPFWAAKLNKTKMKAIQLSKRGGQFHLTLEGKKVKLYGEHYKLNEGKLFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL9</accession>
    <name>A0A654DVL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="172" mass="20216" checksum="363F4D1D502AF01C" modified="2020-04-22" version="1">MVSLRILADRYTSSPTETKLMKIEEAFEEIIKYSHYWNWAPDWGVVIDIYKTFPNSYSVLSPFAYSYLEELIRSTTSEYPLQFQNEDQLVLKKKKVGMSLISLAISESKEKNPEYAIILEELKEYYYPSKITDEGDKRHSVAHGYIHPRFWSQESFEKLILDIAKLSKYAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVN3</accession>
    <name>A0A654DVN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="41" mass="4537" checksum="8E9564C6D0B6BFF3" modified="2020-04-22" version="1">MPKTGMTEREKNVIPVSEARRRPESSPVDGSVGLRELALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS4</accession>
    <name>A0A654DVS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="43" mass="5063" checksum="3610BB835AB16A1F" modified="2020-04-22" version="1">MSMPMIPMSVSVCFYWNNKKYTQLLNVLIINHLNQQPIEQVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW8</accession>
    <name>A0A654DVW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024933657" evidence="2">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="410" mass="46719" checksum="1C1FB34646CD98FA" modified="2020-04-22" version="1">MKKYIIITVITLGFSILANAQSLDEYFKIAAENNPGLQAKYKSFEAAMERVAQVSSLPDPNLSFGYFVSPVETRVGPQRARFSLTQMFPWFGTLKAQENVATLMAEAKYQEFLDARNKLHYQVSAAYYPLYELHRLIAIEEENTSILSSYKDIATVKFQNGKGAMVDVLRVEIMLKDAATNLSILKQKKKPLETRFNTLLNRQEDETIIVQDSLYVENLPLTYRRDSLLTSNPLLDELNLKIKASEAQELAATKQGMPKIGVGLDYVIVGQRTDMSVPDNGQDVLMPMVTMSLPIFRGKYKAAQKEAQLMQESYALQKEDAVNRLTSTYEMIWFEIQKQLDQIILYEEQIMTSQQSLNLLFTAYGNSGKDFEEVLRMQQQILKYQKMKATALSDYNIAIAELDYITAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW26</accession>
    <name>A0A654DW26_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="332" mass="36204" checksum="2B13B8D839737966" modified="2020-04-22" version="1">MKRVATIKDIASALEVSTSTVSRILNGKNQSNAQLVKEVKAMARKLNYQVNTAAKGLRTNKTKLIGIIVPEIGDDFFAAILSGMQEASEELGYNLLVCQSNESKKKENQLVKSLIACNVEGILIAPSKETHNINFLKGLPALGKHAVIFDRIIDQEVFPHISFDDEEGGYLGGKYLIASGHRKLLFIGLSQALKNGVARLSGYNKALGESGLPNCTASFLDTDGTASEILDRYWQEGAYDAVACYNDLIGAQVIAHFNVIGVKVPQEVSVLGFDNRPLCEYTFPRLSSIEHSTNKMGRMAVTTLLDLLNETESEALDIAPKLVERNSVLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW82</accession>
    <name>A0A654DW82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="55" mass="6213" checksum="E9301D3BFCF6DBE0" modified="2020-04-22" version="1">MKVILFLNLTLKQYRAKWGSKIGPHPGGLHQGLVIERFQDNSGSLTYFTAQILII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWJ4</accession>
    <name>A0A654DWJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024809724" description="DUF2807 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="3">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="25159" checksum="7B42C3E27504EF6C" modified="2020-04-22" version="1">MKRIALTLLAALTLFFGMAQSTRNLSSFSEVTAQEGIDVFLTKGSSESARIEADGISVDKVLTDVSGGTLKIHLEGDNHRNVDVKVYVTFVDLSALKASSAASIRVEGMVQAKGDFEISCSSAGDIKVAVKADQVEVDASSSGDVDLEVYADDIDIEVSSAGEVNISGEVRNLDGSASSSGDIDGYDLVCQDADLRASSGASIKVTVNGELTARASSGASIRYQGSPKNTNSDSSSGGSVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWQ8</accession>
    <name>A0A654DWQ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13777" checksum="0030F8E4720ABD97" modified="2020-04-22" version="1">MIGNKLFVDTNILIYLLNGDKEITQILEGKQLVISIITELELLAIPNLSDSEQTVIEELIGECQIINISSGIKKGAVEFRKTRKLKLPDAIIAASAFYSKLPLLTADKAFDRIQELDVIIYSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR3</accession>
    <name>A0A654DWR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13799" checksum="880B47DB99C7167B" modified="2020-04-22" version="1">MIALYIFIALIVGWLIYRTIYLKRKQRQYQGAFVETFKNSETNLPTLKTGYSYGFPSFVVMFKNEELLQQAESNGLTNLFINRIKQIHSEFKEFEAERAIFFTWEGRTFNVYSPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX15</accession>
    <name>A0A654DX15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0382 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="PTHR43461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13603" checksum="14A4C7E2A91FE5C3" modified="2020-04-22" version="1">MDKKHLLTGSILAVTAVGLGAFGAHALAETLETFGRKDTYDTAVRYHMFHALAILFVSILYKNGPHQLLTWTIRFFLSGTLIFSGSLYVLCITNITVLGAITPIGGILFIAGWVTLIIYALRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX26</accession>
    <name>A0A654DX26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="16983" checksum="C274A346507F9F43" modified="2020-04-22" version="1">MGIGEDIKQAKFRSQLNKAIVNIIYTNNWLSQHQVVLFKPYGLTTPQFNVLRILRGQHPKPATINLLIERMLDKSSNASRIVDKLESKGLVARKQCPNDRRAVDVVITSQGLDLLAKTDEDMDRWEDGLVSLTEEEAKQLNELLDKLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX61</accession>
    <name>A0A654DX61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025029416" evidence="1">
        <location>
            <begin position="17"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="446" mass="51134" checksum="B177BC04BA0B7EAE" modified="2020-04-22" version="1">MKVFAFTLLMVIGALAGQGQTRLAFNFPLLDIPQNTQKEHRYPSMSQSMGYSNTLYDLSFWGIDALNNSLFRTDNWKSRTSGYLAGLFFSKYGSELPIPLGVWAHEEYHRSVLGVNGVASKNGNWIFHRWDGTVYGPSDEELADLKTRDVNALLYSYVAGVQYETQLTKENVLFDFYHPRGFYKNPLYLYNAYYVWNYFRFSTSTLSDSVKVIAPKYESDIASERDYAGADLTAWAFDMFSPSASYYDRDDFPDGSGKNRRVGFHDLTPEGQSYLRRQRRLSLLNFLNPSIVMINRIRISEAMTIMPFFQYQPTHFGNALSLNMPFTYEENGYYLGLTQYNNYHHHFYGIDIGVYDFKTSSTEHLSISCVIKLWKQPESFYSAKGKFGGAVQLTTKYAISDEVSLTLQLVSKSAGWMEGNPYLVRKISPIFGLQYTVPVGLDTHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXA8</accession>
    <name>A0A654DXA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="244"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="422" mass="48384" checksum="2004F606DCD9C119" modified="2020-04-22" version="1">MKKLLPGYLNTEIVKSEIKRLEVFIGFLLTGVALSLFMQIRHFNLMRDTFRNPFSFPFILLTAALMIALFTAGRKWVLRLQRKGRRLPRTYFWYTVLMEVSIPSLWLVVTSLIEETSSLLDSPIVFVFFILIIVSSLHLDFWLSACMGMLVSIFIASYTYWVTETYPIKLHLPLAIYYIRSFMFLMSGICAGLVASELRKRLTLTFQEIQAKEQIEGLFNQQVSKEMVEVLKEKQDFTARLDVTIMFLDIRDFTQKVQHLTAQEVNAFQNKFFSPVIEIINANNGIVNQIMGDGLMATFGAPIKDTTHYKSAWNATLKILDFLKSFRETNPEHRTLDIGMGMHCGEVLVGNIGTESRKQLSISGTPVIIASRIEQLNKEMESTVLISKALFDMLSDHIDQHETKGMIKMKGLDKEVEIVKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD8</accession>
    <name>A0A654DXD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="10">3.2.1.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_11732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016714">
        <property type="entry name" value="MANB/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018168">
        <property type="entry name" value="Mannan-1_4-beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024936025" evidence="8">
        <location>
            <begin position="24"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="9">
        <location>
            <begin position="31"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4 7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in maintaining the position of the catalytic nucleophile" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018168-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="386" mass="44135" checksum="3A2102B47E5BEDEB" modified="2020-04-22" version="1">MNYKKRISYLSFLLLGLSLSAQTPIDQKATKKTRNLLTNLHAISSQGFMFGHQDDQAYGVGWKAEEGRSDVKETAGSFPAVHGWDVGSRLDRESNLDDIRFSNMKTWIKKAYKMGTINTLSWHLDNLTTGTNSWDKTPSVADILPGGSKHAEFVEQLDLLAEMLEGMRTTFTRIPIVFRPWHEHNGDWFWWGKGNCTEAEYIALFQFTVDYLKNEKNIHHLLYAFSPDRSRLRLDTIPEQNYLYGYPGDEYVDIIGIDNYGDVGRIGGPNTPEQQENFIQSLKLITKIAREKGKVAALTETGLEGVTKPDWFTEIILNPIKANDQEIDIAWVLVWRNANTTHHYAPYAGHPSVPDFQKFDEDPLTYFEKDMNNPYKRGKALKSSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXW5</accession>
    <name>A0A654DXW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="152"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="543" mass="61822" checksum="5630E8B365C8BA13" modified="2020-04-22" version="1">MGNHTLNIFRGHLYAYLILLSGLCFGQVANILPYPNQIELLKGDFLLDQTTGIISGEESKGLAEDLHVYLQDVGVPVLQVKASKNIVFEKKPAFGREEYEINIQKNEVKLIASGATGWFYSIQTLKQLIPDNVNSSQGVVLKNMRIVDGPRFSWRAFMLDESRHFRGKEGVKVLLDEMARLKMNVFHWHLVDDQGWRVEIKKYPLLTQIGSTRSSTQVGPEKYDSPIQTGERHSGYYTQEEIREIVQYAAERQITVVPEIEMPGHASAAIASYSWLGASKEKIDVPTTFGVFYNVYDVSDPKVIQFLHDVLDEIMDLFPSEVIHIGGDEVKYDQWKESPSIQAYMAEQGLSTPAELQVHFTNNISAYLQSKGRRMMGWNEILGLNLHHYQDESDTQSDQELAKESVVHFWKGDLAMATEAASSDYDIVNSLHSNTYLNYAYRNIPLQMAYEYNPVPDGLQPQYHDKVIGLGCQMWTEWAPSKGQLHYQIFPRIAAYAEVGWTNMKQKDYTRFLSSLEVYSKGWEGRGIYFAPIPIAQSVEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXY6</accession>
    <name>A0A654DXY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="29596" checksum="F8CCDC213CA970C5" modified="2020-04-22" version="1">MIGSSPTKDHFFITFPRPISEDELPEHFSDPFSDEPHPLCILAAEKLQKYLRQQDWEHNFGLESERTENVIGKMFGVLVVRTAEGEIGYLSAFSGKMGGKNHYPGFVPPVYDGLKEGSFLNLGMQELTRINREIEQLMESQPNDHMEKIDALKDLRRSNSMALQDKVFDHYHFLNKDGKEKSLRDLFPNNPPGGAGECAGPKLLQHAFIHHMQPLAMAEFWWGQSPKSGFWKHRQFYPACRQKCEPILAHMLWGTKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY20</accession>
    <name>A0A654DY20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="28987" checksum="C82BA917B5ADF56F" modified="2020-04-22" version="1">MEKMTNEDLSITLQVEQTPLKVYKAINDVSEWWTKIEGGAKNIGDTFTVRFGDVYITHQVEELVPYKRVVWQVKDSSVASWVNTRIQFDISVEGDLTVVQFTHKGMTPQAEDYEDCMKGWTKFINEGLVRLASVIPVTNEEILDRFKALAIEERWFDIQDDLFSTNVKSIDPAHSPYMGYAEGKAAVRKKGKDFVAKVEEFHGARTSEPVMGGNYIAVARDMDITAQGFGRIQINEVMLYEIKDGEIVSEQFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY55</accession>
    <name>A0A654DY55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014819">
        <property type="entry name" value="PriCT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08707">
        <property type="entry name" value="PriCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriCT_2" evidence="2">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="582" mass="66362" checksum="C272403CA37D208F" modified="2020-04-22" version="1">MEKKTFNPLEWMENPAQQSINTEQAQPLSNSNESEVETIIQQIEANQIDITTAYSDWRNIGFAFADEFGESGRDYFHRISRFYPDYSASECDRQFDNCLKAKGQGVSLKTFFYHAKQAGVQISKPKTTSQPTKQEMPNLPDSLFPELPDFLQKVVSVVTSNEEKDLLLLGSLVSISACLPKLFGIYDGRKVYSNMFLFITAQASAGKGRLVHCRQLVNPIHKELREQAKLLKQQHELEMADYNTKKGKEEGVEKPGKPPEKMLFIPANNSSTGAYQLLGDSDGKGLIFETEGDTLAHAFKSDYGNYSDGFRKAFHHETISYYRRTDREYVDIENPCLSAVLSGTPKQVSALIPNAENGLFSRFIFYFMNVRPTWKDVFADTTSQGLDEYFDTLGAEFYELFKVLKASPEMQFCLTADQQAQFNGFFAQVQDHYMTLQGIDYMATIRRLGLIAFRISMILSALRILETGDTSTQIICEERDFQTALAMVRVLVKHSAKVFTELPEDVKPSPRKNRKQKFLDALPQEFNRQKYLEVAKQMNIPDKTAEGYITEFGKSGLIHREKQDHYINLNSQEVQDFKDAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY72</accession>
    <name>A0A654DY72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014512">
        <property type="entry name" value="O_gly_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021505">
        <property type="entry name" value="O_gly_hdrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="394" mass="45513" checksum="8599FAB2179B37C2" modified="2020-04-22" version="1">MKYTVVNILIISIISLIACKEPVDDQLVDPTDKDTTSVEISYKEKAKSVYDFIQNNYKAGDLYRENNPTQGGDNKYCYLWPYVGMLTAGNVLYELGYDQSIHDKEFDGLEFFYEAREELPGYQAYPIIEVKSDHYYDDNCIVAMELIDAYRLLGDQQFLDRAIAITEFIMSGEDSRMGGGLYWLEAVAGDCTSGPNCIKAANTTAYAAFVTSELYKETQEERYLDFAKRTYKWNYNTLRDTSDDLYWNDINIGTNQINPVKWTYNAAMMIMSGVNLYEITGEQSYLDESIATARSSFSKFTSVRDDQLFFPANDPWFNTELMTSFIKLSTYDDKSKEYIEVFIKNADHAWENARTQEGHFYEDWSGNSQGRYFWLLHQACMIEVFGRAAIYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC9</accession>
    <name>A0A654DYC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">galT</name>
        <name evidence="17" type="ORF">MARINOS108_11903</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="15">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="16">
        <location>
            <begin position="181"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD14356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="344" mass="40131" checksum="F6A4DB1167DDEC9B" modified="2020-04-22" version="1">MKAFDKPHKRYNPLTDEWVLVSPHRTKRPWQGKTEEVEETRRPTHDPSCYLCAGNERMGGQHNPMYESTFVFQNDFAALLEGNEQMETSKGLLRMQEETGLCKVICFSPDHSLTMPEMTIESLTEVVKVWKREFEALEQISYIRNVQIFENKGSIMGCSNPHPHGQIWAQSSVPNEIARKTRTQQAYYVKHKRSLLEDYLEQELEDGSRIICRNEHFVGLIPFWAVWPYETMIIPVRHFQAITDMTIEEEVAFADILSKITIRYDNLFKCSFPYSAGMQQRPTDGQSHEGWHFHYSFYPPLLRSATVKKFMVGYEMFANPQRDITAEQAAETLRSLSEKHYKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYE4</accession>
    <name>A0A654DYE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="159" mass="17521" checksum="2F92BB708EF430AD" modified="2020-04-22" version="1">MIKNKLEQLGLELPSPSVPGGNYTSFHIRGGIAYVAIQFPIRSGEYLYQGRLGQDLDTEDGYQAMQLCALNVLAQINQYTTVNQIEGLNHIDAYYQSTESWDEAPLIVNGASDLFVNVLGDKGIHTRSIVGVHTLPRGFSVGLSASLTLRKPARGWIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ7</accession>
    <name>A0A654DYJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="383" mass="41756" checksum="51B2BCFF7337C9E1" modified="2020-04-22" version="1">MKKSFLITIIITLLGLGHTQGQSVYWEQSADNTSSGNLSIGSIAANSYSKLVIKGPNQPLNSGGKRDLSFEFAAAGKAQIRSYRGGSWDTYMQFLTTPVSGGDPVPQMHISHDGKIGIGTTTPVHLLHLKSAMPYMRFELNSGSYSMIEWLEASTRVAGIHWVGHQTPNRLSFMTGVTSISEQMSITETGNVGIGTTNPLDRLTVTGGNVTIGNTTNQEYSLTFRPSDNTARNALVGYSSNTAAADYIGLKSNWGSIRFSTNGGNEVVRITANERVGIGTSDPQSKLAVDGTIRAKEIKVMEVIGAPDYVFEADYNLRTLEATKAYIKENKHLPEIPSAAEIEANGIDLGDMNMRLLKKIEELTLYQIELLERIEKLETNQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYJ9</accession>
    <name>A0A654DYJ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="487" mass="54160" checksum="019FEFB51BFFDFEE" modified="2020-04-22" version="1">MQKIIYALLIAGSLSGCFFNEITDSETVVLLEDVIYVSSNDIRLLGRLYSLEGTASDHGFEFSKDETFSAPEVVSLGEKKTVGLFFSEFNLLEEKTAYYYRAFVISGNNKFYSDIRSISTFEGSVNTVSSLYGESGDQIEIIGTNFTTEMSILFGETTAVVKSRLGGYKLKIEVPGHQTDYRVPVYANFDGRKVLVDTFEYKTGKWTKLSALPFGRMTNAAVRYNGNSASVYLGAFSPSEKNGDIYNYDFTANSWGAPTALADEEYFVEGAFYTPNGFFGAGATRIIEGFSGFIYTLTDRFGKLESDGTITDLGSTPVSGVKPLAFYVDQDLIVLGGLNSGEAIWRYADSEWSYLGQLPFAVNTTVPNTYYNGSIYLFNTEDNTVWMYDLSTLEFTKFTDLSMNVQSGASYFLSGKFLIFGLFPFQSAMYQLNLETGEVLIKNNFEGMASLSTDIQFTEGGDLYVIRGASSTESTEFWKYQPFTFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ31</accession>
    <name>A0A654DZ31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="35774" checksum="E73872C1B4D776AD" modified="2020-04-22" version="1">MADCDIILGYRMQKIRPFGISLMLCLLIISEALGQITDNHFEVRVKNDNAGEISNWLHTGDDLGETHSLHLSAHLLKKHTLYNFRIILESTEYSALNIETAEPRDILFTELNSLQIAIDNNKFGDQSFFFSGAGGLYYIQGNKLTIGAAGQKYYMHKWVISKLYPKRYWIYDRSPVRDIFVPYVELKYGHNQLLFKTAHSSLFTVNNLESRVAGKFHFSGIGARTYFDLKLSVERFNIQDVDIELEGFYLTNITQYQTAYLQIGTRINFEHMAVYTQINQPIKKYLDNPLIKYDDMELQFNYGFLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE8</accession>
    <name>A0A654DZE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_12090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22089" checksum="3FDEA52603AF89DE" modified="2020-04-22" version="1">MNEVGLSEGNVLFPVFLKLNQIQTVVVGGGNVGLEKVEALLKNDPKARIRIIAPLILPALQVLADGSEFIEILNRKVRGGDLKGADLLILATDDYSLHEKLKRKAKKLRLLTNVADTPDLCDFYLGSTVKKGDLKIGISTNGKSPTFAKRFREVLEDILPDSTPELLNQLKTIRDDLKGDFNEKVERLNEITSVLTKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZF0</accession>
    <name>A0A654DZF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8551" checksum="18A26A755208975F" modified="2020-04-22" version="1">MDYRQFLEIRADKRFGKPCIIGTRISVYDVLNWLSNGMSREDIKSDFEELTDEMIDACLAYAADKERRLISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG5</accession>
    <name>A0A654DZG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="22500" checksum="57A055E48B07DAF6" modified="2020-04-22" version="1">MFRKIAVLVMLIILWETGIYFWVLNNTPEALYQLSARYSARTSFVLITIILLWIGATGLRKIYRSAFKRLHLITLILLLAVNHLIHFGFLYANLQPENFGQFILKNHLPALLYVALMISPWLLFSKKTLSTPLYWGILVFLIGLEIIFLQTYVGRLFSPKPLGSPPYFYIGCIVLIGVTLVLNIYRVVTEHLKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZJ2</accession>
    <name>A0A654DZJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="109" mass="12450" checksum="145A17B8DEA829CB" modified="2020-04-22" version="1">MKQISVINSIEVPEGYENEALKIRDAYIEYFKSKPGFVSSTFYRAINANNKFNYVNIVVWDSYESFESVVNSGFENTEGLNEDNRKVLGKGFPPPIKVSPGQFEIIRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZM6</accession>
    <name>A0A654DZM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IPT/TIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024940551" evidence="1">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="121"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="422" mass="43568" checksum="404AD88D9DB7714A" modified="2020-04-22" version="1">MQKLQRFRTLGLICLTALAGLYLVSCGEDEGGSDPKIPVVLSFSPASGEPGDNVTITGTDLDNATAVTIGGADAAIVSNTATEIVATVPEGATTGKISVRTEGGLGQSSADFTVIVIGAVTVSGVSPVSAQVGGNVTITGTEMTTVSSVKVGDKEATIVGTTDTSVEITIPEGVSTGLNSLTIVNDGGTNTTSTEAVKFYVIKLHTDLTMTFDGEQTGTFTGSPDPEESTVYGTSDDAAVIASAQSLPAAIDGNFFQFEGFSSTAISGNYATIVQNSSALPAGTYAEFFSGATDQTIYFNLQIHVGDLPADYDGALFGLRMRFDGDDYEFVPTPAELADMGFAPNEEGWYSLSIPASAFDDDAALGTFQFTDMQRIAVAVRRDYGTGGTAGQQVTAEDGGIFYSQSFDNVSISVGGPYSFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN7</accession>
    <name>A0A654DZN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="33624" checksum="EDC78B9292CC786B" modified="2020-04-22" version="1">MLQKYNPKNEDIKIWVDDRLMDRSEAKVSVFDSSVQGGDAIWEGLRVYKEGVFCLDHHLRRMRESAKALAFESVPSDPTIKSAIKATLQANGMTEDTHIRLTLTRGEKVTSGMDPRLNQKGPCLIVLAEWKPLVYDNEKGIKVITSTQRRNNPQYLDSKIHHANLLNNILAKVQANFANVDAAIMLDHQGFVAELNDTNLFMAKEGVLYTPYADACLHGITRGLVMDLARKLDLPVFEKNLSLVEFYNADEVFATGTMGELTPIHEIDGRKIENKSGQLLRGRLQKAFAELIPTLCEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZP6</accession>
    <name>A0A654DZP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="432" mass="49421" checksum="6B41FEFA5BAC7727" modified="2020-04-22" version="1">MDYKTSSEVQAVKQRFEIIGNSPKLNNAIRIAMQVAPTDMSVLISGESGAGKESFSKIIHSLSHRKHGQFIAINCGAIPEGTIDSELFGHEKGAFTGAHESRKGYFEVTNGGTIFLDEIGELPVSTQARLLRVLENGEFIKVGSSKVLKTDVRVIAATNVDLNAAIEKNKFREDLYYRLNTVPIQVPALRERGEDVLLLFRKFASDFSETYRTKPAYLTEGAQEMLLKFRFPGNIRQLKNLVEQMSVLEMEREIDADTLLKYLPKTTSYLPALIGKTENSENFSERDLLYKVLFDMKKDMSEMKSLIHEILSEDGSRSEILSQHERLFNDVEAYNRPERNEDYDHPPIKPIMLESTREQNTRDRIVEDEYDIEDITHETDDGDSLSLEKKEKEMIIMALKKNNNKRKYAAKDLGISERTLYRKIKQYEIDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR9</accession>
    <name>A0A654DZR9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Component of SufBCD complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">MARINOS108_110031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD15855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="481" mass="53732" checksum="AADBE225B5E3FF9C" modified="2020-04-22" version="1">MSKDDQILEEFTSREYEHGWHVDFEADEAPLGINEDIVRFISAKKSEPQWLLDWRLKAYKRWTEMEEPRWPNVKYPAIGYQDIKYYSAPKQDKKAKSLDEIDPELLKTFERLGISLNEQKRLTGVAVDAVIDSVSVATTFKETLSERGIIFCSFSEAVQEHPELIKKYLGSVVPAADNYFAALNSAVFSDGSFCYIPQGVRCPMELSTYFRINAANTGQFERTLIVAEEGSYVSYLEGCTAPQRDENQLHAAVVEIYAAKDAEVKYSTVQNWYPGDKNGKGGIYNFVTKRGICAGDNSKISWTQVETGSAVTWKYPSCILKGDNSQGEFYSVAVTNNHQQADTGTKMIHIGKNTKSRIVSKGISAGKSQNSYRGQVHIMKRAEGARNFSQCDSLLMGDKCGAHTFPYIDVENSSAQVEHEATTSKIGEDQIFYCQQRGIDEESAVALIVNGFAKEVMNKLPMEFAVEAQKLLALTLEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT3</accession>
    <name>A0A654DZT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_110040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="808"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="98"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="406"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="895" mass="101671" checksum="5A3D16E4DA529696" modified="2020-04-22" version="1">MEDLNIQPPRGANRLLAFFCKTEYLEDIQGDLEEEYILKHQKGPLKALLWYYWQVIRLFRPGLTKSSKINHLIPTNGSMFRNHLIVAIRNLWKYKSGTAINIIGLSTGICAFILIALFIQDELSYDQHHVHADNTYRLTVKNIDKNGELSRHWAFASAGHAQRLKADYPEITHATRFYAWAFPDIQIGDKVFPSEQVVFADKDVFEVFTFPFILGNAESAFREIKSIVLTEQSAIRLFGNDWRNDDILGKTIQITRDATKASFVVSGVMEDMPENQHFHFEYLAPIEFLEPVFGEGMNNVTGNYNWLTYLRLQEGTDPRRIEQYKDDFFDKYVGLFENGIPAKKAYDFELQPLLSIHLNSHLEGEIESNGSLQQVYIFGTVGILLLVVACINYMNLATSHFSRRTKEVGVRKAIGAHKSSLIQQFLTESLMVNLLSFPVAIMLTWLALPYLNDFMEKQLTFNMLENRELLLGLILLLVMVAIISGSYPALFLSRINLIQALKGEAAINSNKWNFRSWLITFQYAVTIGLLFTLAVIEGQMKFIQNSDPGYRKDQILHLSMSRNIRNLDVFKNELLSHPAIHKATYASRVPTGRLADNWNSAFFNDQTAVETTFRLPFILADEDFLETFEIELVAGKNFTAAMEMSTDSVGYYLVNRAAAKALGFDDPEDIVGRKLSYGNYDDHTYKAGRILGVTEDFHFESLHSEITPMVILKGDWNMRTICMQISPGDVQSALAHVEETWTKFDPINSPEYQFMDDLFDQQYQAEERLSTMIKVFTVIAVLIGCLGLIGMVGFIIDTRYKEIGIRKVLGASVFSIISMIGQRFLILIGIGCLVALPTSYFFISGWLDGFVYHINIGLLLVILPAVATLVLTLATISYQTLKASLINPVECLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT4</accession>
    <name>A0A654DZT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9517" checksum="91127061DE80E294" modified="2020-04-22" version="1">MTDEEFDVLDELYFVTPFGVLRETIGWAPAKLIPVLDSIYRKGWIKIMKTIDDELPEGQIDLNNHADEYFFLATKSGLLAHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0D0</accession>
    <name>A0A654E0D0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DJ-1_PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025038559" description="DJ-1_PfpI domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1_PfpI" evidence="3">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="443" mass="49139" checksum="D653DBEE522167F7" modified="2020-04-22" version="1">MRPNSLHYLISLALLSQFSAADAQQKRTYNVAIVVHEGVELFDFAGPGEVFAAAARSNDVANINVFTVAPSKEPVVSQTFLSINPNYSIDDAPPIDILVIPGGRTGVLLNDAKFMAWVKELEPKTDNLLTVCTGAFVPARLGLLDGLKATTHHGSIASLKSGYPNITVIEEEKFVDNGHIITSGGVSSGTEGALHMIQRIAGLKAAKGVARYMEYDHWSPDKGLMAYENEAIKKLKSMSVTTKSRDGMKSDFSGFERELSNVTAEMVDFGELEAYGDELLENNQSELSLMVFRRLSELYPWSIIPFDRMTEVARKTGKNDTPPTEEEFINLIKENGIAAASESFETWQKKYPGWKIFGEGSLNILGYKYLYGPEIDTALGIFQLIVKAYPESWNAWDSLAEGYLKSEDYPMARKYYNKSLKLNPENTNATKMLEQMKTQYAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M3</accession>
    <name>A0A654E0M3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_120377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="207"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="458"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD16796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="577" mass="63846" checksum="5DF8124B7E725A29" modified="2020-04-22" version="1">MPAKDNTNDEYVRKRVDDISKLIYEVAAGNFDYKLKQRDVEGELEGLIGGINMLGEELKASTVSRDFMESIYKGVVDILIIITPDQTIDRVNDAVVDHLGYSPQDLIGRDFKTLLSTEDFSFLQDIQQHLASNGAYHNAELRLLRKDKSLLETSASFSSLFDNQKNHLGTIVIAKDITHIKETERELKKAKEKAEAANKAKSHFLANMSHEIRTPLNGMLGFLELLGGTSLDTNQTEYLDMIKTSGQSLAKLLNDILDLSKVENGKLNIEHVPFNLKSSIQPSFQTYSYLAREKGLDFILDFEPDLPEIVIGDPSRLTQILTNLIGNALKFTQEGSVFIRVSGSRKDNHHLDLLLEVTDTGVGIPEQMRASIFDSFTQADTSTTRKFGGAGLGLAITKHLVALMGGTIKFECPPISKNQDNGTSFFVELPLKVPTSTGRSEHDPAATKETPAFPRGFRVLLVDDNEINILLAQKVLEKLNANVSLARDGKQAHDLALEQKFDVILMDIQMPVMDGFEASTALRKAGYQAPIIALSANVYPEEIKTCFENGMNGHIGKPFTVDGIFNKITSVINESPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M5</accession>
    <name>A0A654E0M5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tufB</name>
        <name evidence="7" type="synonym">tuf</name>
        <name evidence="10" type="ORF">MARINOS108_120513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="395" mass="43098" checksum="91103CD5B817B75F" modified="2020-04-22" version="1">MAKATFDRSKPHVNIGTIGHVDHGKTTLTAAISSVLASKGLAEMKDFSSIDNAPEEKERGITINTSHIEYQTEKRHYAHVDCPGHADYVKNMVTGAAQMDGAIIVVAATDGPMPQTREHILLSRQVGVPALVVFMNKVDLVDDPELLELVEMEIRELLSDYDFPGDDIPVIQGSALGALNGEPKWVEKVEELMNAVDEFIPLPPRAVDKEFLMPVEDVFSITGRGTVATGRIERGVINSGDPVDIIGMGAEGLKSTITGVEMFRKILDRGEAGDNVGLLLRGIEKSEIRRGMIICKPGSVTPHAKFNAEVYVLSKEEGGRHTPFFNKYRPQFYVRTTDVTGEIMLPANVEMVMPGDNVTIEVNLINPIALEKGLRFAIREGGRTVGSGQVTEILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N6</accession>
    <name>A0A654E0N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="17351" checksum="ECF4CF5683B9071B" modified="2020-04-22" version="1">MISFRQATRTDLPAIIQLLADDPLGQLREQPSDPLSQSYYQAFEVIDQDPNQELMVVVEAEEIIGTFQMTFIQYLNYQGGSRSMIESVRVRKDKRGQKIGEKIILWAIDRSKSKGVKMLQLTSDKKRPDAIRFYERHGFVASHEGFKLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0T1</accession>
    <name>A0A654E0T1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SLATT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="173" mass="19735" checksum="0BB0AD33A0520508" modified="2020-04-22" version="1">MQNTTEKVRRIKVDALYGKKKHFNAADRNQSIHYRIGVPLIVINVITGSILFYALTDGIAGWIKYFPLVLSFVSALLVGFQTYFNFQKKVEGHRRIGNRYLAIMKKCDRLLGYFADNAVSESELIDRLEKIAHEIEEINKEAESLPTSDKDYKLAKAGIEAGEESYTENELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V9</accession>
    <name>A0A654E0V9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="285" mass="33099" checksum="888A6397E6437D77" modified="2020-04-22" version="1">MNKDLGFMLYCHEDYAKVQHFQSYHRFHSDHIVFCVECIDNKAICLPKSPIGGFTCFNGRKSDFLQFYEKSEKSLTQNGISSLEITLPPHYYTGVPDRSWLEQLGFSERVSEIAHYIPINGPLWEKIHTMQQRKLKQTPTFDLSLVNVSELRSVYDFIAQCRKNQGLEINMDFEILERLFRTFPDRYQIFTAERNGTLLAAAIMVIPIEGITYYFLPATAPAYKTESPMVHLIAYLYQYYQERGFQFIDLGISSVNTAPQKSLITFKERMGGIRTTRSTFIKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W0</accession>
    <name>A0A654E0W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="214" mass="24278" checksum="B78B55855FD3FCB7" modified="2020-04-22" version="1">MKIALSEIWNFSELISADEQGWSYKLVAGSVVVADISQQVLVGLKSDEEYDTELLPSIFTFREILWQPDVFTESVKSLPGLRILKAHCEDIITTYEEGGTETQLLYSALLKGLAACSEEAIASLESESVSVKKALGEFRTAAFPIVKFFIFHPQNRVDYYKDAVNRLNYAVKIMLTQFHGKYTELSDPYWEVIYSQPNKEVKTARKAVEEKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W2</accession>
    <name>A0A654E0W2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_110054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="499"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD15879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1059" mass="122302" checksum="07197BF42A8BE514" modified="2020-04-22" version="1">MSKPFHIYRSGAGSGKTFTLARSYLTIALGRPAAFRHILGVTFTNKATEEMKNRIVAILKTLAAGEAHPMEADLCADLGIGKGELQKRASATLSDILHQYGRFSIVTIDSFFNQVIRSFAREMGLQGTFTIDLDQKTVLERVIDKMLQEIGEADKKQLRSWLTEFAEFKVEDGKSWDFRRDITALSGEILKDEFKKHSAAVLKLSETPGYFDKLKKELNEIRFGFENQVKRFSREFSEYLEQEGLTVGDFSRGKGGPAGLFQKLEALDFEISEPRRAAMDNLEAWLTKPNLKKGHLNHYLESFILPKYSQTINYIDQHFVRYASSLEVQRYLFTFGILAQVNKYIQNYRDENDVMLIADLPDFLHQIISDSDTPYIYEKVGSNYSHYLIDEFQDTSAFQWENFMPLVKNTTDEGNFSMVVGDVKQSIYRFRGGEWELLQNRLKDDIGDYHVEAHNLDTNWRSDQRIIDFNNFFFESARDFSKDHFFNQTDNVLDPVLKQRVADRVSEVFDTFSDVAQKGSKEEAVPQGSVSLEFISDDDTGDDEKWADEAITRTIRYAEDLQRKGYELRDMAILTRYSSEGRKVADAFLAFRNSEEADPDLKYDVVSSEALYLTSSHLVRFIVSLIKWLNDEKNTIVLNEWLYEYRRYISQEEITESGIFASYREWKEVVPNEFIKHKEYMKTLPLYELVEGIVRIFELNTFKQEFTYLQGFQDAVLDYSKNERGDIPSFLEWWEEVRKERAIQISNDNNAIKILTIHKAKGLEFPVVILPFLGWGFDHDGTKDNILWCEGALADAPFNRLPVIPLKYSSKLANTYWAEAYYQEKLKAYLDNLNLLYVAFTRPIEVLIGFAKLPKPKAKFGSTYDLMHPLLSDTEGWDESATAYRIGEIPGKENVRQSTLEFGLTEYLSTPWRSKVSVQIKGSAELSEAVFVDATLQGIRMHEVLSKIHCTSDLDQYVDHSDYEQLKTIISHPELADWFDPQWMVANEVPILLPGGDFKRIDRINRSEKETIVIDFKTGTKRSKDKSQVAEYIRILKEMEYPGVRGYLVYLSDLSVEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W4</accession>
    <name>A0A654E0W4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024955046" evidence="1">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="372" mass="42842" checksum="A9FB5AD366587834" modified="2020-04-22" version="1">MKTVIIATLLFICQVSYAQLFDNPVNMQLVQKGVYFIYNVEEDSADVYIEKVEARLPKHPTVPMMRALKVLWANIPLVTVDSVFKVFSGHLRETIRLAAYLDGGRQTHPEAIFFEMAARGLLAEYFADDGHYMKALSEASKAYDLIKKGFDLSEEIPEFLLTTGVYNYFREKYPEKYPVYRPLLWFFRSGDVELGIQQINEATQKAVLTRVEAYVYMSYIYLRYEYQPQKAQSYLWELTKAYPNNLYIKAKLLESLTPKNDFVQAPVPVIKELSNSDRPYYQMAGASFMGIYHEKVKGQPDKALNDYQKALRVGQEIPGHGTYYRTLAYLGLGRVYAKKGMKGQAEYNLRKVLESGESEDLLSEARDLLDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E104</accession>
    <name>A0A654E104_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="21202" checksum="D065A449A32FA213" modified="2020-04-22" version="1">MTKSIDFNTLLVKRLRNRDVTAMDYLYEHYSDALYGIIYRTLKHTEIAEETLHDVFIKIWDQIESYDASKGTLFTWMYRIARNRAIDARRSKDFKTADKSDDITGFVDMFESSSNAEEDYIGLSGVLSEIGEMCKKLIQLNFFMGYSHAEISKNEDMALGTVKTRLRNCLKDIKLKLSKDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A5</accession>
    <name>A0A654E1A5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tfp pilus assembly protein PilF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="561" mass="64390" checksum="2938397E8FEEA7E9" modified="2020-04-22" version="1">MLLCSLLGYSQKNNQGGDFAPLDVTELSEGEALKAETMLIDAERELILDNEYKALELFKAVLEIAPNNPVVNFKIAEILIKNGESREALPYATKAMNLDKSNKYYILLAAEVHKALSDFDEAARLYQQMIDEIPGTESYLFDLAIIYQYQGKNEKALATYRQAEEIFGMNEMVLREKQKIYLKKRDYPSLIADWDKLIKENADNDRYAIELCEFLISQNLMDEAKERLQNLKNNKHADLLMSEIALSEGNTALAMDLAESTMGSSDVDFQAKLQVLNRFLDFVITSEEFDKVSQMAMSLAADYPNQYEVQAFTGDVMYRLEKKEEARKFYLKAIKLDPTNYGVWQNILSVESDLNQFDSVIVHAEQAMEYFPNQAALYYFAGTGYLITKNFKRSVQVLDQGKKYATDPKLLTIFYGQLGDAYNGMKQFDKSYSAYDDALKADPQNDHVLNNYSYFLSLRNEKLDKALAMSTRLATMHPDNPTYLDTHGWVLYTLGRYEEALIYLRKAANLQDDGTVIEHYGDVLYKLGRIDEAIDQWKRASQYEDASKNIEKKIADRKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N8</accession>
    <name>A0A654E1N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-linked SusC/RagA family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="132"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="464"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1077" mass="117807" checksum="4DA32E773061D6E7" modified="2020-04-22" version="1">MRKVYSRSEMIQSSIKRLMGVCFMTFLTLSLSVTTAFGQERTISGVITSGEDGSTLPGVTVLVKGTTNGTITDIDGNYKISVPEDATLVVSFVGFKTQEFPVGTRSSIDVTLDIDISTLEEVVVVGYGTQKKSDLTGAVASISGDKLRGTVVTNMDQALQGRIAGVQVNQNSGAPGGAVSIRIRGTSSVSGGNEPLYVIDGIPIDGGGPTITGFDWSGGANGQNKVNPLAAINPNDIVSIEVLKDASATAIYGSRAANGVVMVTTRRGKSGEAMITYDGYYAFQSLPKKVDMMNLREYAEFQNSVSTEIDGINVNERFLDPSILGEGTDWQEEVFEVAPMQSHQMSFAGGNDAFTYALSGGYFSQDGIIIGSGFERVSMRLNVDAKVNEWAKVGTSISYADIDEVITLNDGGDGVIAQSLVMSPAVPVRDLDGNFAGPTANSAEIGANPVALALMRNNTLEREQLYANFFADLQLMKGLKFRTEYGISKNHSLNRAFHPTYQWGVLSNDVNSLNQSESTGDFWLVKNYFTYTLQSGIHDFTALLGQEAQKSTYRGSSFQKTGFVDENITTPNQGQNSANPIGGYQGANTLSSYYTRLNYILSDKYLFTVTGRYDGSSRFGPNNKYGFFPSASFAWRVMNEEFMPKSKVLSDLKLRLGYGEVGNQSIANYAYGSGLTTENTWIGTGSRNSRFANPDVKWEASRQMNLGVDLSLWAGRIDLTVDAYNRQSRDLLLELTSIPASIRGDIGAPYYNVGQMENKGIEISLNTRNIEANKFSWTTDIAYTMNRNKVLNIDQPYTQNLYWYAGFQTVTRTTSGNPIGSFYGYQTDGIFTDAEDIRNSPTQVDDQSIEGNQNLIHQRDGVWIGDQKFKDLNGDGVIDVNDQTSIGNPNPKFTGGINNTFSYAGLTLNVYFTGSYGGKILNFQRVRNEGMSSLNNNQAATVVNRARVEFINPDDPDADMTNPDDIRLANPGTDIPRFSPTDNNTNDRMSDRWIEDGSYLRLQNVSLSYQLPKGMLNKVKVSSMRVYVNAQNLYTFTNYTGLDPEIGAFNQNALLQNVDMGRYPSPRVVTLGTSITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1W8</accession>
    <name>A0A654E1W8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="52" mass="5967" checksum="ADD5A688B728E807" modified="2020-04-22" version="1">MTESVDRATFALLFRMILNNQANEKTLTLYSTGFNHFHRPRPVLSGAGDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E230</accession>
    <name>A0A654E230_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="296"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="521" mass="58612" checksum="A3982583CFA33E73" modified="2020-04-22" version="1">MKSAANRLIITVIGTILLPIIVYSVYEISSITEDEEVIEKVYHEQLNAIIFSVNQFSDDNLSSILNKLEDNLSDSLTLSDAEPFLAFSNFNVLLLKAADSSQARAVVLNDRLKPRNWLALQDSLLAANPELSEQLLRYKAGGYRKIEPIGTIRLDGENQQIIRAVLDTKMGEIQLTGLLSIEGFANNVLAPKLQQIAEGELVITLGYSATNQLVYLTDSLTNDVILRKSMWLFPDLEVGISSSSKTVKELVEERMYYNLGSSLLLISLLIFGFSLVVRNFRREMHLAQTKSDFVSNVSHELRTPLSLISMFAETLFLDRVPSQAKRKEYEEIILKETNRLTNIVNKILNFSQIEANKRTYTPTRTDINELLREVIHDYAYHIEKNGFTHSCELTEPLPQPLVDREGLYEALVNLVDNAIKYSDQEKNLVFRTGQKGNAVYLEVEDKGIGIATDKVKQIFEKFYRVTDGNVYTTQGAGLGLALVSHIMDAHNGDVEVESTLGKGSTFRLVFYLENHGENISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E271</accession>
    <name>A0A654E271_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MARINOS108_20359</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="12">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="5"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD18652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="436" mass="48346" checksum="1B946D1CA76C657C" modified="2020-04-22" version="1">MKVLKFGGTSVGSPERMQEVAEIITGVSGKKIVVLSAVSGTTNILVSIGEFCANDQREEAIAVAQDLRQKYYDFVRKLFPKEDFASQNTAFVDEIFDNIEQLAHQKYSDQVAKMLVAQGEILSTRFFTDYLKMTGKRCEMIMAQDFMTLDKEAEPDLKTTKVKLDHLLAGQKENIIITQGYIARSAAGGIDNLRRGGSDYSATIIGAILGAEEVQIWTDIDGMHNNDPRIIKTTHPIARLSFEEASELAYFGAKVLHPHCIVPAQMHEVPVRIKNTMDPAAHGTLISAEQEPEAVKAIAAKDHITAIKIKSSRMVMAYGFLKKVFEVFEKYKTPIDMITTSEIAVSLTIDNSEFLKEIKAEISKYGTVEIDKNQTIICIVGDLIAERKGVGSAIFNALDEVPLRMISYGGSRNNISLLVAEEYKKEALIKLHEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E291</accession>
    <name>A0A654E291_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014327">
        <property type="entry name" value="RNA_pol_sigma70_bacteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02985">
        <property type="entry name" value="Sig70_bacteroi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="191" mass="22215" checksum="B0E8CD3EDCF9646E" modified="2020-04-22" version="1">MHNTVKIPTEEKAFRDLFEEYYAPLVLFAFNYVKDQDEAEEMVQEVMTNVWIKAETITITSSVKSYLYGCVRNACLNHLKHQKIVNQYQTHQLATAPASFDETPLELEELQEKLRTALDKIPARCREVFELNRFEGLRYKEIAAQLNLSLKTVENQMGKALKILREELGDYLYLIIWSSSGMGVIFELIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U5</accession>
    <name>A0A654E2U5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="327" mass="36178" checksum="527DA1F791F737AA" modified="2020-04-22" version="1">MQYRKLGDSDLNVSVITFGAWAAGGWMWGKTERSQAVAAIRSAYDQGVTSIDTAPIYGQGTSEEIVGEAIKDIPRDQVQILTKFGMRWDTSRGDFFFASKDNSGKDIDIYKYAGKESVIKECEDSLKRLKTDYIDLYQIHWNDSTTPIIETFEAVARLIEQGKVRHAGVCNYTAAQMAEAEKAVKLVSNQIPFSMVNKKVEDKTVPYCIVNNKSVLAYSPLERGLLTGKIKPGQKFQEGDHRSTNRFFTEESILKTNAFLEKIKPLADEKGATLAQLVLKWTIERPGITIALAGARDATQSVQNAGAAALNLSTEEISFINSALSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E368</accession>
    <name>A0A654E368_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">recX</name>
        <name evidence="5" type="ORF">MARINOS108_20380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="18913" checksum="1D0F137124C56632" modified="2020-04-22" version="1">MDRRALLKQAKAKAAKFCSSKERAPFQVYEKLMAWELREDEAQEVLAELTEERFVDERRFCKAFCHDKFEFNHWGKNRIQQELYRFRLSQEVITEGMNYIDPDRYQKTLEDLARKKWNSLMDELWPKKQKTMAYLIGKGYEIDLVMETVNQLSVSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G3</accession>
    <name>A0A654E3G3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024888418" evidence="1">
        <location>
            <begin position="22"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="3">
        <location>
            <begin position="45"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="267"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="550" mass="62927" checksum="539517F0C4A31251" modified="2020-04-22" version="1">MNPSKFFTLLFVLFLSTAGFAQKSFTRQDTLRGSITPERGWWDLQHYNLSVSIDTAARSITGSNVITYKVVSAATEFQIDLQAPMEITEVKQGDRVLTVRHEGDAHFVTLVDDQPVGSIQKLTVWFAGIPVVARRPPWDGGFTWNKDESGKPFIATSNQGIGASIWWPCKDHPADEPDNGVTMNFTVPKDLTAVGNGRLIKVKKGKGTRTFTWQVTNPINSYGVNLNVGDYVRFEEKYDGEKGKLDMIYYVLSYNLEKAKTHFKDARRTMEALEYWFGSYPFYEDSYKLVEVPYLGMEHQSSVTYGNGYELGYRGRDLSLTGWGLKWDYIIIHESGHEWFANNITYKDAADMWIHESFTTYSEGLFVDYHYGKEAGAAYVRGMRYGIGNEEPMIGPYGVNGRGADLYNKGSNVLHTLRQWVNDDTKWREILRGLNETFYHQTVTTADVENYISAQSGLDLTSFFNQYLRDPRVPVLEYFTYEGNLLYRWTNCIEGFDMPVRISVGDESFTITPTSRWNFRDQEKIAVEDPAMLKVDPNYYIYPVYITGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I2</accession>
    <name>A0A654E3I2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="426" mass="45130" checksum="941418D2A86678E6" modified="2020-04-22" version="1">MKIIRSILYSGVLVMLLTSCFPEDEDLSLGEIVEAAFTITDISTSEMRNTYLLESSSEGAFIYKWDLGNGTVITGSKTDTAFFESKGVYTVSLTVVSAGGQSTTEQQVTVEADASTGVNVLLGSEMDDESAWTFTSTGSTMTSYTFSDGKLILSNGTEVAQTNIAVWQEVELTGGTDYQFSASASGSGMTNSWVEVLLLDEEPQEGVDPSATPIAGLNTWTGCGGDAFDGKLPAISCIGDGKVSVAEDGTYYLLIKVGSWDGNLGTTGLILDDVVLVGLDTTPLVEGDNILVGSNMEDENVWTVTNVGLTLTTVEFVDGVMKFTNGSEPAQTNVGVWQAVDVEAGQKYRLKATVVDPGATGSWIEFYVHTTEPSDGTDYTQGRIEIGGDTSFEEAGTVYFLIKVGSWDGNLGSGVTIDDAQLVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I9</accession>
    <name>A0A654E3I9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gcvP</name>
        <name evidence="9" type="ORF">MARINOS108_20416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="957" mass="104872" checksum="32D97CCA9A1E93E8" modified="2020-04-22" version="1">MTVDLNERVAFQTRHNGPSEKEIQEMLDALGVSSLDELISQTIPGNIRLKQGLNLPAPLNEYEYINKLKKTAGKNKVFKSFLGQGYYNCVVPAVIQRNILENPGWYTAYTPYQAEIAQGRLEALINFQTLVSDLTGMEIANASLLDEGTAAAEAIAMLHATRKKEKKQSNKVVVDERVFPQTLEILKTRTKPLGLELVVARIENIDLSDSDLFGVFFQYPDNFGETFDRSAFVAEAAEHGVSVAVASDLLALCLLTPPGEWGVDVVVGTSQRFGVPMGYGGPHAAFFATKEEYKRYIPGRIIGVSKDDEGHPAYRMALQTREQHIKRERATSNICTAQVLLAVMASMYGVYHGPAGLKQIASRVRGLAKATAASLSAMGLKEENAEYFDTLRFTLNDDDLQKVKNVAESHQINFRYAGNQVMLSFDETHLPSDAQNVVSIFAEALGKETQTISTEVEIAYPNGLARQSDFMTHEVFNVNHSEHEILRYMKRLENKDLSLVHSMISLGSCTMKLNATTEMIPVTWPEFGNIHPFAPKDQAAGYAEVIGELHDWLAEITGFSAVSFQPNSGAQGEFAGLMVIRAYHQANGHHHRNITLIPSSAHGTNPASAVMAGMEVVIVKCDDQGNIDVDDLKGKVETHSENLGALMVTYPSTHGVFEESIIEICELVHAHGGQVYMDGANMNAQVGLTSPAMIGADVCHLNLHKTFCIPHGGGGPGMGPIGVGAHLAPYLPGTSHIGVDDVNVSSAPYGSASILPISHAYIAMMGGDGLRAATQLAILNANYIGQKLKDHYPVLYANEKGRNAHELIIDCRDFKKYGVEVEDIAKRLMDYGYHAPTVSFPVAGTMMIEPTESETKSEIDRFCDVMISIRKEIEEVISGVADKDNNVLKNAPHTQRTVIAESWDLPYSREKAAFPLPELKYNKFWPSVSRIDSAYGDRNLMCSCVPVEAYAEAAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3J8</accession>
    <name>A0A654E3J8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="22365" checksum="7F8AA36749C6C7A6" modified="2020-04-22" version="1">MTNSKLDKPIVGGLLLAAGASSRLGQSKQLVEFDHQPLLRRTLQTLFHSHLNHTMTVLGARAQEHLAVIAHMATDTCINEAWEKGMGHSLKFGMLRLLEAQPALDGVLIAVCDQPFLTTAHIDGLLDQFAHSRHSIVASEYKGIQGVPAIFPQAHFGELMSIGDEAGARKVIAAHADQVILRHLEKGEVDLDTPEDLKHLRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3L3</accession>
    <name>A0A654E3L3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cysS</name>
        <name evidence="13" type="ORF">MARINOS108_20501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="375"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD18989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="493" mass="56115" checksum="6EA0BE4FEFB703D7" modified="2020-04-22" version="1">MIGKLRIVNSLTKEKEVFEPLSAPHVGMYVCGPTVYSDVHLGNVRTFISFDVIYRYLQFLGYKVRYVRNITDVGHLLDSGEDKISKKAKLDNLEPMEIVQKYANDFHRVMDTFNALTPDIEPTATGHLMEQLVMIEQLVEKGFAYESNGSVYFDIEKYNEAHEYGKLSGRKTEDLLNQTRELDGQSDKRNPLDFALWKKAAPEHIMRWKTKWSDGFPGWHLECSVMSTKYLGDEFDIHGGGMDLKFPHHECEIAQNAGSTGKDGAKYWIHTNMLTVNGQKMSKSLGNSFLPSQLISGNHELLQRGYSPMTIRFFMLQSHYASTLDFSNDALNAAQKGYTKLANGLRLIKGYEFPEGIEENPDPKQVEQINKICDNCHHAMNDDFNTALTIGHLFNLVKKINSIQTGQLELAAIGKETFERMKETFISFTEEVLGLKLESSVSSDHLLEVILNEYKSAKETKNYEKVDELRAQLKSEGVIVKDMKTGIDWAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3U4</accession>
    <name>A0A654E3U4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="26154" checksum="65DCD5AA08B9B4B0" modified="2020-04-22" version="1">MQKGSVFLIPTYLSDHHEASFLAPLVLDVIKNTDYFLVENVRTARRFISSLKLGLDISTLEFEVLDKKSTPAEISQYMAPVIAGKDVGVISEAGLPGLADPGQLAVTFAHRNGLRVIPLPGASSIQTAVTSSGFSGQQFTFHGYLPIQKAERLKAIKNLEQQLTSTGYTQVFMETPFRNMSLISDLVDTLSHHVNLNIAADIFGQHEFIKTQTIAAWRKQKKDLHKIPSVFSIGHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E422</accession>
    <name>A0A654E422_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024891933" evidence="1">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="277" mass="32847" checksum="3EAFACD1CE9F8225" modified="2020-04-22" version="1">MRYGLLITALVITFTSSVAQRSVTDEMKDTEDELYASTKQINQFFHRFNGEEDERGNRYYPQDKKYRDAGLRKKYLPILFDTETGYVKTETANSFIKEVLDKKNPVFLDFHSGDWFAEVNTTFLYKGKEVSVLLYMILQQQGQGYEWVIDDLSFDPYKSSFKKDTSEQKMFIHPMSHELDFMTLRKAFRNTQNPEQYTSRKWEPDYLTLFLFEMKGGALEFKTVKNVKFHFFEVDGWYFELSNFNRPGYNTGWLISNLVKVGAAEQKQMKDYLYDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E481</accession>
    <name>A0A654E481_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="24140" checksum="4D6FD098108F7B1E" modified="2020-04-22" version="1">MKERIAIGAYMIFGTLNITAQLIDAPQLAQTSKILLVPTLIYLVFVMAGGMVTLPRLLLAVGLTFSWAGDILLLFPDEEIYFLGGLGMFLVAQVLYTIVMYKSAYSKPRVNVKALLPIVLYGVILFYFILPHTGNLAGPIIAYAACILGMVSMARFRQGKTSDESYQLAFFGAALFVLSDSFIALDKFVIDIPLSTFWIMSTYIVAQFLIVKGVMSHPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4B5</accession>
    <name>A0A654E4B5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021272">
        <property type="entry name" value="DUF2851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11013">
        <property type="entry name" value="DUF2851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="423" mass="48762" checksum="43E67316EE93B0F3" modified="2020-04-22" version="1">MDEYFLQFLWKFQKFESKELILSKGSSLTVFQTGHQNHHSGPDFLEAKIKIDDLTWSGSVEIHYKSSDWNRHKHQTDRAYENVILHVVWINDGDILINEEPLPTLEMSQYVATNLEQEYRRYINQPEVIRCGPKLGDIPQIQISAMIDRAVASRLQEKSVRVLDTLEQLGGDWEETVYQTLARNFGFKTNAEAFLKLASSLPYHVIRKHAGKEQQIYALIFGMAGFLEDPVDEYQASLSTEFSYLAKKFQLHRMLDRHHWKHAKMRPANFPSVRLSQFAAFLTQENQLLANLLNISGRKEAVGFLQKSLPDYWSSHFDFGKPTTKSPRIGTKSIENIIINSLAPVLGAYSKYLDEVIYLERAQHILEQLPPESNHIIQKWIDRGITPGNGAETQGLIYQYQSFCTPKKCLRCNIGMFILNPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4G8</accession>
    <name>A0A654E4G8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sterol desaturase/sphingolipid hydroxylase (Fatty acid hydroxylase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MARINOS108_60085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid alpha-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="PTHR12863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD20903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="204" mass="23564" checksum="EAD400D4C30C24D4" modified="2020-04-22" version="1">MELKNKPHTKGTKALFKNPVLERLTRTHIAIPLILFSTISTILIVYGINQGYINAVNTPLLFVAGLLAFTLIEYIMHRFLFHLQPKTDKQEKFAYTVHGVHHDYPKDKDRLAMPPPLSIVISALFFGLYWLIMGNLVYGFLPGFLMGYASYLWVHYMVHAFKPPKNFFKVLWVHHGIHHYKDQHNAFGVSSPLWDVVFGTMPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M5</accession>
    <name>A0A654E4M5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6095" checksum="4FCB83CE6B8B73BA" modified="2020-04-22" version="1">MSNSLDTLFLRSNFADKIVMNKVLKTNFGNAASCLGVDQYYTEEWQSGRMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U8</accession>
    <name>A0A654E4U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024922261" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="219" mass="24422" checksum="E41D554B4FD2066F" modified="2020-04-22" version="1">MKSAAAILILGLGACAPAGVVPFINDPVTIDGKANDWSEDFDRTEFGELVYALAMDQYFAYVLVEGIGEKTKRLMFDWGLTLWLNPDGKKVKSIGIRYPVIDRSKPDPSPGYTRYFRVPKPGLDDFGLKGVISNQMLVVQKSRLQLDLDVVMGLDSLSNNLIYEFKIPLKFLEMKSKKGLESLAVGFEVEDSGRGIGPMLAPGYRRTDKINFWYKAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F9</accession>
    <name>A0A654E5F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nusB</name>
        <name evidence="8" type="ORF">MARINOS108_60017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="264"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="389" mass="46019" checksum="1B71C29B8A50FD96" modified="2020-04-22" version="1">MLNRRILRVKAMQALYSYFTAQESLKDVVRERLESQFYPDPAKDDFAESDKFTARRKTAARLFTENLQHRSVTEETEEDVKDAAERSIEAYHTELRKEQRNIRNVMINDIADIHKLYFKLVALPLEFAHQEKLEKDKKEKAHIHKESAWRWHFIQNPVIDALTKHEPFTKGLIELKISWDEDADQIRTWYKDILKADPVLIEYQTKEQPTDDEHKEAILHLFKKIIFKNESINEFLSESDLRWTENKAVLKSLVVKTFQDYEKDLDPSYEMKEVITNKEDDMEFFEVLFDETLKKSKEWDDLIVKKVKNWDISRVALMDRIILKMALTEMMQFHSIPVKVTINEFIEISKLYSTPKSKQFVNGILDVLANELTSDGVIRKSGRGLIDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5H4</accession>
    <name>A0A654E5H4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="254"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="490" mass="54280" checksum="C1D063ED7BB60FD9" modified="2020-04-22" version="1">MKQLLVLSTALLVSFGSFSQKLVKDIDKKVQLSEIKSHLYFLASDELRGRNTGTLENEIAARYIAERFRSYGVKMAPGMDSYFQPVSLIKEVSPQKATLSVGEKTFNLGDDMVFYSSTNGTFSGEVIYVGFGLEDDLEGKDLKGKIVVAKAGNGNPDERLTPYTIQKQEMVEAAGGLGLVELYKPGRYPWKLIQYYFSGEKYRLDKGEVGGKSTFPSAWLYDSGDVLAYFEESDGALATITIEGKNNLSISVPNVVGYIEGTDPTMKSEYVMISAHLDHVGVSKADGDSIWNGARDNGIGIANMLTAAEYLSKNPPKRSVAFLACNAEEKGLLGSRWYADHPVFPLEKTVFDLNTDTGGYNDVTKVTVVGFNRTSVTPLFVKSAQAFGLTAIDDPLPEENYYDRSDNVSFAAKGVPSVSYDPGYTEMNEEITKYYHQPTDEPNTLDYEYLTKYSKSFIYAVWLIGNRTEEIFWEAGDKYEEAGKALYGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5S4</accession>
    <name>A0A654E5S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfate exporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="473" mass="51105" checksum="C1C83716BFC02954" modified="2020-04-22" version="1">MGLVEENSYLFGKFERMKWTEDLVAIATGVLILGFALVVFVMAPYGNASEQTITGSVEIEQTTLTSHLHLMTAKLQKWEYNPLDTFAGKNYCWGLLSLLLVFASVLGGGAVMMGTPLKKFLGGFALVFLVGLVAYVLQSQVSFKSIGLGYALWAIVLGIFISNTFGIPDWLRPALKHELFIKTGLVLLGAEVLFGKIMAIGLPGIFVAWVVTPIVLVTTFWFGQRILKMSSKTLNITISADMSVCGVSAAIATAAACNAKKEELTTAIGLSMVFTSVMMVALPAFIKAVGMPEVLGGAWLGGTIDATGAVVAAGAFLGDRAMNVAATIKMIQNILIGVIAFAVAVYWTTKVDRVQGKKVPASEIWVRFPKFILGFIGASIFFSLLQATLSPELSEALIEKQLFGFTKEIRGWLFCLAFVSIGLSTNFKELRSQFSGGKPLILYVCGQLLNLGLTLLMAWLMFYKVFPEITSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Z9</accession>
    <name>A0A654E5Z9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="33251" checksum="7AEB7471279DD16E" modified="2020-04-22" version="1">MENTKVLAFGEVLWDFIEGYKHFGGAPVNFAAHMVQCGREASIVTAVGTDKLGDQAVEEMIKLGVGQDFVQRNSHLTGRVMVFLEEGQPTYRIRNDVAYDYIEQSGIDTAKLSEYGAFYFGTLAQRNPESKAAMDFIMARGSFNTIFYDVNLRRDAYTKEVIESSFGYCTIAKMNDEEVRVLSSLLYEAEMSQDDFTVRLLVDYPNIDLLIITGGGQGCVIRTRSEHYKVSAKMMLVKDSVGAGDAFCAAFLNAYLRTRDARKSARIGNMVGGFVVSESGAIPIYPEKFRRKIEVLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E624</accession>
    <name>A0A654E624_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C4-dicarboxylate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_90010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17389" checksum="B7FFC27997D56428" modified="2020-04-22" version="1">MKNKIDRFLEKILVLLMAVMVLNVLWQVASRFLLNAPSGFTDELAGFLLIWVGLIGSGYATGQGLHMAIDILPKSLEGARFIWVMRFIHFSVALFALLVMIIGGSNLVYVTLELEQLSSALQLPMGYVYLAVPLSGALMIYYSIYYLIYTESNGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6B7</accession>
    <name>A0A654E6B7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="28828" checksum="0E45D72FC174F5F1" modified="2020-04-22" version="1">MNRQQIFLIAAGVLAVVLIYQLPRVVVENETGVEVKPHDFSISTEDQSLLMSLRQQLNAVSEIKKSINFADSLARLYLKYQMVDSADSYAALILSLDTAGTSRLKAAMIYYQAFQMSTEPDKAVGLAQKAQEIFEELLVADPQNSTLKNKLAMTLMVTETPMAGVQLLREVLEQEPDNRETILNLGLLAIRSGQFDRAKERFEKLLEMDSTDDESLFYYGVVLSESGDTEAAKAVFGKLLNKADADPALKATASSYIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6D6</accession>
    <name>A0A654E6D6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lpxD</name>
        <name evidence="7" type="ORF">MARINOS108_11497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="6">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="37167" checksum="FFEE532748585CAE" modified="2020-04-22" version="1">MNLTVGQIAEILNGEVAGDPNILILGISSLEDAQCDSVSFLANPKYEQHLYNTHAAAVIVGVDFVPKQSTKTVLIRVNDPYLSFTALQAEYQRLTILKKTGIEAPVHLGTDFSHSDGLYLGAFAYIGDHVTIGKNVKIHPQVYIGDHCTIGDHTIIYPGAKIYERTIIGAYCNIQAGAVIGSHGFGFAPKPDGSYQNIPQTGNAELGNHVDIGANTTIDCATLGTTRIGDGVKIDNLVQIAHNVEIGKHTVIAAQTGISGSAKVGKHVMIGGQVGTVGHIHIADHTKVGARSGVTKSTKSDQILFGVPAMDRHGYLKSYAIYKKLPELMACIQELEQKILNLTPNSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6J5</accession>
    <name>A0A654E6J5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain containing-hemolysin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_20368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="428" mass="48968" checksum="6348D0B45AA0DFEC" modified="2020-04-22" version="1">MEDPSLYLGILTCLLFSAFFSGIEIAFISADKLHIEVMSKKGSFTGRVLSEFVTRRSSFLATMLVGNNLSIVLYGILMAKFIEPWLYTVLPEALTEDIVVLILQSLISTLIVLITAEFLPKSLFMLNPDTMLTVFALPMALIYYALYPVVLLIVFISRFIITKILRFEYSEDKPVFGLTDLNNYVKKNILNIEKEEDAEIDAKIFNNAIEFKTIRVRECMIPRTEIQAVDVSDKIEELRSAFIDTGHSKILVYKESIDDVIGYCHSVEMFKKPEKIKDILTPIIIVPETMLANELLIQFITERKSIALVVDEYGGTSGIVTMEDVIEEIFGEIRDEHDDEYLVEEKIDDYNFILSARHEVDYLNDKYEWGLPVGEYDTLGGLILAFHEDIPTVNETILIPPFHFTVFTMEENRIDKVKLTLLDKEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6S7</accession>
    <name>A0A654E6S7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">MARINOS108_20448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="429" mass="47343" checksum="5C2E35FC663B57C6" modified="2020-04-22" version="1">MTTSTSKKNSQEYINLENQHGAHNYHPLPVVLSKGEGVYVWDVSGKRYYDFLSAYSAVNQGHCHPRIVETLKQQAETLTLTSRAFYNDVLGPFEKYITEYFGFDKVLPMNTGAEAVETAIKICRKWGYEKKGVEENKGQIVVFDQNFHGRTTTIISFSSDPDAKRNFGPYTHGFIKVTYNDLDALREVFEDNKNIVGVLVEPIQGEAGVMVPGDSFLENVAKICKEHNALFMADEIQTGIGRTGSLLAVCGNCTCSGHCEQQSTYIKPDLLILGKALSGGGYPVSAVLADNPIMEVITPGTHGSTFGGNPLGAKVAMTALEVIRDEKLTQNARKLGKIFRTRMEKLIEKTELICLVRGKGLLNAIVINDHSDSSTAWDICVALSENGLLAKPTHGNIIRFAPPLVMDEEQLHECCDIIEKTILNFKQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8L8</accession>
    <name>A0A654E8L8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025055282" evidence="1">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="23655" checksum="A0586FE86ED374D7" modified="2020-04-22" version="1">MHLLKSISRYTLLALILSACVPSVSYYNWVAPDHDFKKFDKIAVFGLTRDLQDASDFEVGMVGQLRKDGYLSIPGMTVIPPEWVKDLDVKSIRKHLISKGVDAVISLAVVDVSTRAIFVSGSNYIIPADRSRFGNTYISTYKEIYQPGYYTQSSTFIYEAHAYDLTSEDVNNNLIWTYQYKYDAATPGVPQLSPFARTLMDALKRDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E981</accession>
    <name>A0A654E981_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="222"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="37371" checksum="E261856D8326C00F" modified="2020-04-22" version="1">MSKRKIVFLILPKVHLQDLAGPAQVFYEADQLHKNTFELRYAGLKTDTISEQGLQLGGLEDFTHLELTREDYIFLPGIDFASYREQPVSEAETRLFSWLKDCHHEGVSIASVCSGALVLAKAGLLDHIRCTTHWKCIDYIQQAYPKTRVQANKIFEEDRRIYTSAGMTSGIDMSLSIIEAICGPLTAAHVAREMVVYVRRSGTESQKSYYLDYRTHFNPTIHQVQNYLINHINENPTLSELAEEFCVSERNLTRLFKKHAGLTIQDYKDVMRLELAAHLLHNPNYTQKYIAGECGFHDERQFRRLWKRKYHYPPSRHPEKVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9E4</accession>
    <name>A0A654E9E4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">topA</name>
        <name evidence="10" type="ORF">MARINOS108_120119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD16269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="776" mass="87036" checksum="3ADA68595FB0A180" modified="2020-04-22" version="1">MAKNLVIVESPAKAKTIEGYLGSDYQVKSSYGHVRDLPKGDKAIDIANGFKPTYEVSADKKEVIRELKKLAKAAETIYLASDDDREGEAISWHLKEALNLNDSNTRRIVFREITKNAIQNAIQNPRGIDIDLVNAQQARRILDRLVGFELSPVLWKKVRRGLSAGRVQSVAVRMVVEREREIDQFEAQSSFKISALFDLDQGKVLQAELGKRFKTEAEAQAFLNLCTGADFEISNLETKPAKKSPAPPFTTSTLQQEASRKLGYSVSYTMSLAQKLYEAGKISYMRTDSVNLSQEAIASANSEISGSYGKDFIQNRSYKTKSQSAQEAHEAIRPTDFHVQSVSAGSAEGRLYELIWKRAIASQMADAQLEKTTATISISTTDEVLVARGEVIKFEGFLKVYLESTDDDEDEEQKSMLPPLAIGQKLDLQQMLGKEGFTRPPARYTEASLVKQLEEKGIGRPSTYAPTISTIQKREYVIKESRDGKERQYVELVLAKGQINKTTKTEMTGAEKNKLFPTNIAMIVNDFLVEHFENVVDYSFTADVEKEFDDIANGTKAWEQMIQSFYGKFHTKVENTDSLERADISAARELGTDPKTGKNIYARMGKYGAYVQLGESPEKEDDEKPQYASLKKGQFLENVTIEEALELFKLPRNLGEFEDKVMTAAIGRFGPYIRHDGKFVSLPKEMDPLTVTEEEAIELILAKREADANKFIKTFDEDPEVQVLNGRYGAYIKFGKKNVKIPKDKVPEELTYAECKELADKTPEKKGRGGGARKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9R1</accession>
    <name>A0A654E9R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">MARINOS108_120221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD16446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="17100" checksum="A3510FF1DFA11B5F" modified="2020-04-22" version="1">MSALNYYTKEGLDRLKNELNELKTKGRAAMSKQIAEARDKGDLSENAEYDAAKDAQGLLELKISKLEAVVGNARVIDESSLDASKVGILSFVKIKNKKTGMEMKYQLVAEEEADLKQNKISIKSPIGSGLLGKKPGDTAKINVPAGEIEFEIIDISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EB08</accession>
    <name>A0A654EB08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="74" mass="8886" checksum="90C5A95A9F302CF1" modified="2020-04-22" version="1">MYQPDKIALDHEYVISTFSVEELRAGLECSLRVKRHLERHVRIDSKVRYMNNLDVLNQIIYQYEEALTKYKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBL3</accession>
    <name>A0A654EBL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aceA</name>
        <name evidence="8" type="ORF">MARINOS108_20107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="425" mass="46675" checksum="59E6C7B74278BD22" modified="2020-04-22" version="1">MIMKTERIQKIQKDWDENPRWKNIHRPYTAEEVVNLQGSVPIEHSIARITAEKLWKKLNDKPFVAGLGALTGNQAVQEIAAGLEAIYLSGWQVAADANLAGAMYPDQSLYPADSVPSVVKRINNALLRRDQIENLNGDSSIDWLAPIVADAEAGFGGNLNAFELMKAMIEAGAAGVHFEDQLSSAKKCGHLGGKVLVPTQEAIDKLVAARLAADVMNTPTLLIARTDADAATLITSDIDKRDHRFLTGGRTNEGFFEVTNGVEAGIARGLAYAPYSDLLWMETSNPDLGLAREFAQAIKAEFPDQMLAYNCSPSFNWAAHLTKSEMFTFRENLAEMGYKFQFITLAGFHALNTSMFELSKAYKERGMAGYSELQEREFALLDSGFKAVKHQAFVGTGYFDAIQNTVQQGRASTVAMEGSTEVEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC29</accession>
    <name>A0A654EC29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="152" mass="16963" checksum="C2C29FCE24B7AC8E" modified="2020-04-22" version="1">MNSDLTNISPTFYGISMVPKNKWREYGFALLTIAGSDGIVSDPELEWLTLDMAKEVGVDEEIVADWEEFDFEAAELDEIFSSFNSSALAGFSKLLIYDAIRMSSADGDYALEEKEQVYDAARILRVPQEVVIAIEALVDLEQAANKLRLTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EDP9</accession>
    <name>A0A654EDP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15903" checksum="0FEB47B05505FD7F" modified="2020-04-22" version="1">MRVVLILFAWLLQSPFQGWETLSRLELVSGFDDFLGEETEVPVFSEELKGFEGEIVTIEGYVIPLQTSREGDFFVLSRFPYNNCFFCGNAGPETVAEIYTKDKVATEDSRVRVTGRLELNANDPLHLFFILSEARVTPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSX0</accession>
    <name>A0A654DSX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="14163" checksum="5EFAAE3505827055" modified="2020-04-22" version="1">MSTETKVCTECGRELFGRSDKKFCSDACRSAYNNKALAGGDKYMRTVNRRLKKNHSILVQLNPDGKTTTHREKLLKAGFDFDYCTNTYTTKDQKEYRFCYDQGYLHLGNDFILLVKREPSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT04</accession>
    <name>A0A654DT04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="73" mass="8153" checksum="646586CFFDA722C2" modified="2020-04-22" version="1">MKKSSPNSNPSNSYWANLCLRPKSRRTLAKDHPIAQNLTGAVVDVEAAAEKGAGKRDNSNFTLWRILTELCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTG9</accession>
    <name>A0A654DTG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11530">
        <property type="entry name" value="NTP-PPase_DR2231_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033653">
        <property type="entry name" value="NTP-PPase_DR2231-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023292">
        <property type="entry name" value="NTP_PyroPHydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="17871" checksum="1A2CAC4649B88188" modified="2020-04-22" version="1">MDKIDSLNQVSEFHKTFKHPVLETPQIPSAERCALRVSLIQEELNELQQAIQDKDIVEVADALCDIQYVLSGAVLEFGLGDKFVTLFNEVQRSNMSKACVSQEEAQQTVDYYQNEKGTEAYFVEKEGKFLVYRKEDNKTLKSINYSPANLKKIISEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU18</accession>
    <name>A0A654DU18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="321"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="451"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="802" mass="91417" checksum="E5D675915FB76F1D" modified="2020-04-22" version="1">MLKNYFVIALRSFRKNKAYSLLNVLGLAIGLACCLFVFTIIRYENSFDNWHTKKDRIYRVVSHYHGDNRIYYSGILPYPTGDAILRDLPDFEKVVQFHGPEDEKISLIDASGNFQVFRQSGILYTDEHFFEVMDFEILKGAPGEALKDPYKVYLTQEMATKYYADENPIGKMVKLNNDKDLEVVGIVQTPPKNTNLPFKMIVSLPTMRLRMPDAFRDNWGMTWAFSCYALAPENADIPELERKLDAAMDAYDRDLEDREKSTIKLQPLSEIHNDERYGDGQNYVTPSLMIWAFVLLGALILGTACLNFINLSTAQAIRRAKEVGVRKVLGSLKSQLFWQFMIEILVIVLVGMVIALTLGQILISKFNTFLTEIEYDLSYGSDVIWFAILLAVVVAFFAGLYPALILSGYKPVDALNHKINIRKGSGNINLRRILVITQFAFTNLMLICTVIIAAQMDFMKSKDLGFNFDRVVTIDFPDGAYLKMDAIAGEYRSKSYVEDVSKSRTTPLSNSNWNNSYFIKGEEYIDGNNANIKHGDKNYLDFYDIELLSGRNIPEQHINDSTYDIIVNEKLLTTLGWKTHEEAIGQWIDMGYIEGKVIGVMEDYNVRSLQYGLKPAIFMYKSDEFNQLAIRLKSEPSPDVVADIEATFRQFYPNDLFEFEVLKDEIQDHYVLENMLHQIIKFVSVLSILLGTMGLYGLVSFMTNKNAKDIGVRKVFGASVASILGIFGREYTKLMLIAFVVAAPLAYWLMSLWMEEFAYRIDITYGYFVIAFGISFAIALGTVGYRSFRAATANPIQSLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU40</accession>
    <name>A0A654DU40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FecR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032508">
        <property type="entry name" value="FecR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16344">
        <property type="entry name" value="DUF4974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="97"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4974" evidence="3">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="32826" checksum="66A84C573F38682B" modified="2020-04-22" version="1">MSNWIQKYNQGTPSKAQNLEEQDDFDLFMEMSEFDQPVDVDAAWNKLHTQLVPKRSVTPLLLRIAAVLVVLFGLGYAVTQNIDTKAPATLSEVISSDQLQEVVLPDGSVITLAKNSQIQYDETSFPEKRAVNLKGEAYFEVTKGSVPFIITSASGKVTVLGTSFNLNTRKGLQLLVTSGTVRVETEQDKRMVYKGQQASATNQGSIRVATAPNMNLLGWKTGQFKFENEPLDQVLPLLERYYQVKISTNKSIRQCRITAEFDETPLENVVDIISTILNAKSHISGDNIKFSGKGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU50</accession>
    <name>A0A654DU50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoquinoline 1-oxidoreductase subunit alpha</fullName>
            <ecNumber evidence="3">1.3.99.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iorA</name>
        <name evidence="3" type="ORF">MARINOS108_10615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047121">
        <property type="term" value="F:isoquinoline 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="16102" checksum="DD4D796442FEB293" modified="2020-04-22" version="1">MAKFALTINGQERQVDVDPATPILWVLRDHLNLVGTKYGCGIAQCGACTIHLNGMATRSCMLPVSAVGNNEITTIEGLSEGANHPVQQAWMQHDVPQCGYCQSGQIMSAAALLQSNPKPTDEEIEGAMSGNICRCGTYVRIKAAIKTASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUH3</accession>
    <name>A0A654DUH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gln_deamidase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041325">
        <property type="entry name" value="Gln_deamidase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18626">
        <property type="entry name" value="Gln_deamidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln_deamidase_2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="32594" checksum="9AFC995390F56CE6" modified="2020-04-22" version="1">MIPSVHAPLISPEDYELLLGAKPPTPELTPISFAEREELLDLVIAENIEYRYINGSCEDRAHYISLLLKKHQVTAGKIWNFAPARYSLSSDELFNMTDPLGISENTTWGYHVAPFLTAYNEQGEIETLVIDQSLSADALLTIDEWLALMNCPRSIYLLTDADSYLFFSLNNYLMQDESAPADEWPAFLPSIITGNFWNLAPGDDYVQKGLSINDLALEIFSIKNQLPAHEEAYLHELLKNIDDVIRLTEVAKPAELSSKTYRSLISYYDQRYAHWNDRVAHTQACLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUM9</accession>
    <name>A0A654DUM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="146" mass="15787" checksum="8733247A1F657F44" modified="2020-04-22" version="1">MMVAIATYLTFNGNCREAMTFYQKCLGGQLRFQTVGESPLSEKMPESMKACIVHASLSNGVMKLMGSDMVPESGLLKGNSVSLSLTCSSTAELTRLYRKLSSGGLASHPPEQTRWGALFGELTDKFGNRWLLSCARHTSTGVISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUR4</accession>
    <name>A0A654DUR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="13851" checksum="A860632406BC9C0D" modified="2020-04-22" version="1">MNNPVHWFEIPVTDMDRAQKFYETVLDQKLDVRDFGNFVMAWFSSNPTQPGSGGTLIKAESYVPSHEGSLIYFGVAEIDDVLPRVEPAGGKVLNPKTSIGEYGHVAHFEDTEGNRVAFHQPPAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV96</accession>
    <name>A0A654DV96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CusA/CzcA family heavy metal efflux RND transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="901"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="977"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1457" mass="160646" checksum="8BE75DD5D8D27215" modified="2020-04-22" version="1">MLDKIIRFSVQNKLIIGLFTLGLVVWGGYSLRQLPIDAVPDITNNQVQVITTSPSLSAEEVERLITYPVEITMATIPEIEEIRSFSRFGLSVVTIVFKEKVDVYWARQQVNERMAAVEAQIPPGVGKPGMAPITTGLGEIYQYVIGTQPGYKDRYDARELRSIQDWIVRRQLLGTPGVADVSSFGGYLKQYEIAVDPDHLKAMNVSIGEVLRALEANNENTGGAYIEKGLSALFIRSEGLISSLEDIGNIVIKNNQDGIPVLIKNIGKVQLGSAIRYGATTKNGNGEVVSAIVMMLKGENSADVIHNVKSRIEEIQKTLPEGVTIEPFLDRTKLVDNAIGTVTKNLTEGALIVIFVLLLLLGNLRAGLIVASVIPLALLFAFSMMNLFGVSGNLMSLGAIDFGLIVDGAVIIVEATMHHLGLLRLGRKLTQSEMDEEVYQSASKIRNSAAFGEIIILIVYLPILALVGTEGKMFGPMAQTVSFAILGAFILSLTYVPMASAMFLSKKTEYKANISDKIMSFFHKTYSPTIRWVMHKRVLILTLSAAFFACSLWVFSTMGGEFIPTLEEGDFAVETRVISGSSLQNTIKATTQAEKILLAQFPEIEQVVSKIGSGEIPTDPMPPEAADLMIILKDRSEWVSASNREDLANQMSAALSVIPGVTFGFQQPIQMRFNELMTGVRQDVAIKIYGEDLESLSGYAGQIGKIVSEVDGAVDLYIEEVTGIPQIVIDYKRDQLAKFGLNVREVNQTIQAAFAGSSAGLVYEGEKRFDLVVRLSKSNRSNLDDVRNLYVVRPDGHQIPLYQVADVSIKDGPYQIQRDDTRRRIIVAFNVRNRDVESIVTEIQRRIEASVVLAPGYAISYGGQFENLVEARQRLAVAVPLALLLIFVLLYFTFGSVKQGILIFTAIPLSAIGGILALWMRGMPFSISAGVGFIALFGVAVLNGIVLISEFNRLKSNGVADVFERIYQGTHVRLRPVILTAAVASMGFLPMALSVSAGAEVQKPLATVVIGGLITATLLTLVVLPVLYYYFEKSIKLRPGALLLLLLGTACLYATPSYAQESGVRYLSADEAMTLALENNPGLRAIDLQTEQQRVLKGASWSIPKTELSLTHGQYNSAYTDDNQFNISQSLAFPTVYANQRKLSGAQIESQERRYLASANELKQQVKATWYEWWWQESRLQLLLSQDSIFQRFAESATLRYETGESNLLEKATAASQVAEIAVRIQQTRVDIEILRTQLKTLLNTTDNIGIEMEPMLLQQDFHLSEEPSISDNPTLVWYQQQIEVADRQKSLEKSQLLPDIRLGYFNQSLNGPGQTRAGDPIVYSSGDRFTGFQVGLAIPLFGANAQVSEVKAAELKKQQTNLQLEAMTNELNGQLSALIQQHQKSLSSLSYYQENALPQTELILEQSQKGFASGEISYVEYVQGLDRALSIKFNYLDILNQYNQTLIRISYISGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA5</accession>
    <name>A0A654DVA5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043739">
        <property type="entry name" value="DUF5684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18936">
        <property type="entry name" value="DUF5684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="130"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="426"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="486" mass="56509" checksum="A0A3D8373AA1D514" modified="2020-04-22" version="1">MYLNDFSLSFTLILVIGWYLLQSIAYYKFFEKAGQPSWIGFVPFYNYYVHLQIIGRPVWWLFLLFVPVVNFFIALTIHLDLLKSFGRYSYKDQSLGVIFAPIYMVYIAFSSASYEGKATEMPKRVRTVGQEWFEAIVFAVFAATFIRWIFMEAYVIPTPSMERSLLVGDFLFVSKINYGPRTPKTPLQIPLTHAKIWGTEIPSYIEAIELPQFRLPSLGKVERNDVVVFNYPVNDTYNRRPDGDFHPLDLKTHYIKRCVAIPGDEIEVKTGQVYINGEKGTDPEMMQHKYFVETDQVIRDRVFSNYNIWEYGPAVTPEGKKGYVVLTTKSEAEQLVQLDFVKSAEPMFMNKENAEPRIFPNSTYFPWNADNFGPLTIPGRGFTIQVDEYTLAKYGSTIEDYEDLEDVVIEVDKLIIGGQEVSEYTFTKDYYFMMGDNRHNSEDSRYWGFVPEDNVVGEASFIWMSMDEKGSFLSKIRWNRLFNVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVH1</accession>
    <name>A0A654DVH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14752" checksum="9C8DBB54E1245EF2" modified="2020-04-22" version="1">MQPKSCTYISNHMVADKHKSTRRDVFQAIADPTRRAIIFLLAVSALTPNAIAEHFDTSRQAVSKHLKVLVECEVVTQEQQGREIHYHLNVNKMKDIEKWLEQFRQIMENRFDNLDQYLAQLKSNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK3</accession>
    <name>A0A654DVK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase, PHB depolymerase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024866254" evidence="3">
        <location>
            <begin position="20"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="421"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="740" mass="78577" checksum="2D50B9DE0413F444" modified="2020-04-22" version="1">MKKLFLSIMMGVYFLSAQSQLSLVSNFGSNPGNLSMYRYTPANIPANAPLVLVLHGCTQSASTYASESDWNSLADTYKFHLIYAEQKSSNNSSKCFNWFETGDINRGSGEAASLKNMTDYMKNNYSIDNSRVFVTGFSAGGAMTTVMLAAYPDVFSAGAVMSGLPYKVATSSNSAFQAMYGNVNQTPTQLGNSVRNASSHTGPWPTVGVFHGTSDYTVYYMNQNEIMEQWTNVHGTDQTADAENGAFQGNSVVSRKEYRDGSGNPVVVTYSLSGMGHAIAIDPGSGATQGGNTGSYASDVNFFSSYWSAEFFGITGAPPISLSPPTNVSATAVSSSQINLSWTDNESTESAYLVKRSTSSGGTYSTIATLAPNTTSYSNTALAASTTYYYKIVVQDANSNTASSGIVSATTSSGGSSNPPAPSGLATTSITTSSIGLSWQDNSSDENNFVVERSTNGSSYSVIATLSANSTSYSNTGLTPSSTYYYRVKAQNSYGSSGYTSAVSATTSGTATVVTIEQLTGTGIFTYGNAHHMGQSFTAIANGQIIEIEANLVYAISGSTLKIFSGNTTTDTPIYQQSGVSKGSGWQTITLSQPVSVSNNSVYTFQLTNASIKYAYSNVYSGGNLWYDDISYSPFDVGFIVSISTGSSSRLAAEGITPESNQVGFRVFPNPASELLHVTSDLDDLPGVIEIYSLSGKVVYQKAMAGKIDERIHLSEWTPGIYTVVLQTGHQRLTHKLIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK5</accession>
    <name>A0A654DVK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smc</name>
        <name evidence="5" type="ORF">MARINOS108_10753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="520"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="304"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="669"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="832"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1174" mass="135689" checksum="F6913D18C9A23937" modified="2020-04-22" version="1">MQLTRLEIKGFKSFADKVTINFDEGITGIVGPNGCGKSNVVDSIRWVLGEQKTRVLRSDKMENVIFNGTKARKATQLAEVSLTFNNTKNLIPTEYSNVTITRRYFRSGESEYLLNNVPCRLKDITNLFLDTGIASNTYAIIELKMVDDLLNDKDNSRRSLFEEAAGISKFKIRKKETMRKLQDTDADLDRVEDLLFEIDKNLKSLEKQARQAKKYYEIKEEYKQYSIALAKKSIGDQNAVFESIEKRITQESDRKNSLNTQLLEKEANLEKTKAELIGKEKLLSSRQKTLNEHVGKIRNYESEKKIKNERQRYLQDKIEKLQEQLSQDKLSNERAAFSLKSLDKESDQARQILSDIGNKLEQLQADYDAQKAKTQEAQEILNEYNQQYNTKREQVYQVGKDLEIKEVQIKSLQSELNRSREDSSIQSESLKDFDQKLAEIQKEKVAKTEEFQALKAKETALKDKIESNQQRIDLIREELTQVNRKLDSRQNEYNLTKSLVDSLEGFPEAIKFLKKSNQWKNAPLLSDVIACPEEYRISIENFLEPYMNYYVVETREDALKAVNLLSDSSRGRAHFFVLDQLEKYHANSAHIFANTRPATEVVEYDEKYRKLIAHLLDNVYIYENEAPSTEDDDVVFVDKSGKITKRKFSMSGGSVGLFEGKRIGRAKNLEKLAAEIKILTKKQEQAKSNLNENLNELEQLKKSTQTSLLEELQVEINRINETFVSIQTKQEQYSNLLNSNETKREDIEERIETLGSEIDALRPEFDQSAGILSELEMQVVNKREELNELNELLAQKSSAYNEENVLYHRQQNKVNSITQEISHKDETFVSSSARIEQNTEELQKATQDLNELVKKSEESDDDLVAMYEEKESIEMGVNEAEKDYYAVRNAIDEAEKNVREIQRMRESADQVLMEWQNKLNETKIQLNSIKDRLSVEFNLDMKQVELFDNEELLNQPLEDLRDRVDKMKNRLENMGPINPMAMEAYEEIKTRHDFISEQKEDLIKAKESLLTTIGEIDEVARVTFLDAFNKIRDNFIKVFRTLFTEEDDCELKLTDPDNPLESSIEIMAKPKGKRPLTINQLSGGEKTLTATSLLFAIYLLKPAPFCIFDEVDAPLDDANIDKFNQIIREFSKDSQFIIVTHNKRTMASTDVIYGITMIEQGVSRVVPVDLRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVL3</accession>
    <name>A0A654DVL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024530">
        <property type="entry name" value="QSregVF_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40613">
        <property type="entry name" value="PTHR40613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12843">
        <property type="entry name" value="QSregVF_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="7045" checksum="015886EAB1DED9EF" modified="2020-04-22" version="1">MPYGKYKGVAICNLPERYLIWLRSKGFPEGKLGMLLNTMYEIKLNGLEYLLKGLKDPSHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS0</accession>
    <name>A0A654DVS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="57"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="398" mass="44694" checksum="CC9B527B2E84F307" modified="2020-04-22" version="1">MKKRQWMILGITLGVLVLAFGMSFFFAGQKEAPEMKKPPVVKKYVKTVPVSYEDIQTHVMAFGRVQTAQSLDLLSEVSGRMFEGQVRLKEGQNFRKGTLLFYIDDKEATLTLKSQKSNFLRDIAAILPDMKIDHSGNFEAWEAYFASIDINKDLPELPEAKSEKEKTFMATKGIYSTFYTIKSAEERLKKYRYYAPFDGSISEVNMESGAFINPGTKIGTIIKTGSHELKVSVETKDIPWVQLGTPVEIYSEETQQSWAGEVIRMSDFVNQNTQSVDVFISIEPGKQKIYDGQFIQSAIPARKVENGMIIPRSALYNSNEVFVVEDTLLKVKQVFVHRTMDENVIISGLEVGEDLVVEPLVSAHNNMIVFKLEQKDIDRETGAPDSTNPPVGGNLGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS5</accession>
    <name>A0A654DVS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="255" mass="29795" checksum="9F39FDC6D639F9E2" modified="2020-04-22" version="1">MYRHLAPLFFISFVLACNRENTETLPCPPIVTEGTYDYPVKPGTPEWEAFTSRDQMVAVSQIPEDILETISTDALLETLLHCPMVMDYIFYDELQKGFSHIATDINGFEELYIRDDLYKALIQRLQKMDLHCQNAYPPIIDGAYANTDLAFQTYDFFLFQDDLITKLDQNIQTELFDIIYMTVKQRKEYGHNDYSLLVAYATLGKLMLQLDYLPFVKSVERTPYLAMFCEEIPVYRPIDIFPIDTVEKYTLEMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVT9</accession>
    <name>A0A654DVT9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SiaC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="15007" checksum="9FE8A9FA1A801B85" modified="2020-04-22" version="1">MEKIFIEPTRVTPLVNFDPDEGLLEIKGRSSPENSILFYQKIIDNLDEYIQSDLTDFKANFSFEYFNTSSSKCLFDVFKRLSRIEESGKGLTINWYYEEDDEDMMEAGEDYADLLDLEFNFLEIEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVW1</accession>
    <name>A0A654DVW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="27080" checksum="EBBB9FAF87CD684C" modified="2020-04-22" version="1">MNAAIQEYLLTLESEFVRHANPQIAAQQEAYLKNQFRFYGLTSPVRKAVQKPFLDKNYLPPKQDLPGLVKALWAKPEREYHHFAQELACKYLRQPELTDMALYEYMVAHHSWWDTVDHIANKLMGSYLLRYPQTRGEYVEKWLSSGHLWLQRSAILFQLKYKEDTDSALLSSVIHRLLGSKEFFINKAIGWVLREYAKTHPEWVIRFVEETPLAPLSRREALRIFERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY1</accession>
    <name>A0A654DVY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease BN (tRNA processing enzyme)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="243" mass="27428" checksum="6B5E9E4C13C19507" modified="2020-04-22" version="1">MKLTILGCGDAFGSEGRFNTSFMLEQDHRRILVDCGASTLIRLKQLGILVTSIDTIVITHFHGDHYGGIPFLVLSNHIEYQRTTPLTIIGPSGVEKMVFALQEALYPGTSKILEALNITFVEYKDKHWTNTNDLEVYARPVTHAIPSHPHGVKIRWEDKVFSFSGDTEWNDSLIDLADGSDVFVIESNNLKEDSPGHLSYQTILERRALFNTKRMLLTHMGAEVINRNSLEIERLSDGQEIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW20</accession>
    <name>A0A654DW20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">thrS</name>
        <name evidence="12" type="ORF">MARINOS108_10864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="244"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="649" mass="73976" checksum="D748694E97AF73B9" modified="2020-04-22" version="1">MSEIKITLPDGSERQYEKGVTAMDVAMDISEGLARNVLAAKVNGEVRDATRPINEDATLSLLTWNDDEGKSTMWHSSAHLMAEALEALYPGVKLGIGPPIENGFYYDVDFGNQVFDAENLKAIEDKMLELAREKNPYVRKDISKQDAVDYYQKKGDEYKLELLEGLEDGNITFYEQGNFTDLCRGPHIPHTGFIKAAKVLSIAGAYWRGDEKRKQLTRLYAITFPKQKELTEYLALLEEAKKRDHRKIGKELGLFTFSEKVGKGLPLWLPKGAVLRERLENFLKKAQVKAGYEQVVTPHIGSKELYVTSGHYAKYGEDSFQPIRTPAEDEEFLLKPMNCPHHCEIYKSSPKSYKELPVRYAEFGTVYRYEQSGELHGLTRVRGFTQDDAHIFCRPDQVKAEFAKVIDLVLYVFSALGFEDFTAQISLRDPENPDKYIGSDENWDRAEREITEVAAEKKLKTVVELGEAAFYGPKLDFMVKDALGRKWQLGTIQVDYNLPERFELEYTGTDNQKHRPVMIHRAPFGSMERFVAILIESTAGDFPVWLAPEQIAVLPISEKYHDYAHSVYSFLQQEDIRGYIDERDEKIGKKIRDAEVKKIPYMLIVGEQESESGSVSVRAHGKGDQGSMKIEEFKDFFNNTVKELLNKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW62</accession>
    <name>A0A654DW62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="407" mass="46302" checksum="51BC7411DB226B50" modified="2020-04-22" version="1">MKKENPKSLSLVILMILFSCHQEVDVTKISPPMEPGVVPSSTANSAYWTKAQETHNFIYGNTLTSYDSYHANLTTNYNNCWEWYNVSHIYADAEMVRQGDTQYLPYMNDTYTFMGNMWDYASSGLGGYFSSVNLDGTGAGGDKYVDDNSVTGITYLDCYNVTSGTQQTQYLNSAIAVANWLMNAGVWDYTFNGGFWWNDGTKNVAPNVKPTQTNGLAMHLFIRLYDLTGQSYYLSWANSIKAWLESEMYDSSDGLFIWQIEPGGTKRYEKFTYDNAIMIEAYLAYYDVTGNNSYLTKAQNLGIALNTVLWDYTSNVYEFNTSDPRVNPAWCGWGSQAMIKLYEADGNSAWLDYAQDNIDFINSHNRNTTNHGYYHFTNLNGTLSDGKYESVDQAWMQRIQGMLAEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWA0</accession>
    <name>A0A654DWA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ice-binding protein (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ice-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021884">
        <property type="entry name" value="Ice-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11999">
        <property type="entry name" value="Ice_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="31"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="241"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="567" mass="58292" checksum="83300936C7124CA0" modified="2020-04-22" version="1">MKIIKSGLVLALLPILMFVGCDKDKDPVLVSPDVVSTAPADDATGIAVTAAVQFNFLADMNPETLNSTTVVLMEGTNKVATTVSYANKKLTMTPVANLKNSTVYTATVKTGAESELGAALENDFTITFTTVAEVDNEVPVISSTSPLANAVNITKGNSVSIVFNEPMNPATINVTTFTLVKGTTAVAGVVSYADNTATFTATESFESNTAYTARITTGAQDLAGNGLAADTEWSFTTTDFAAPFINSTAPLSDATGVARNKTVSVVFNEPMNPATISAATFQLKNGTTSVPGVVAYSGTTATFTSTTILEASTVYTAQITTGAQDLSGNGLANNESWSFTTGEVTATLAMVNLGGASNYVILAKTAINNSSTSAITGHLGLSPAATSYITGLDLVDATGYATSSQVTGNVYAADMADPTPVNLTTAVNDMITAYNDAAGRPTPEFLELGTGNIGGMTLSAGLYKWTSTVTIPADVTLTGAADDVWIFQISGDLTQSSAINMTLNGGAQAKNIFWQVAGEATFGANSHFEGNILSMTGITFLTGASINGRALAQTAVILDANAVTKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWG7</accession>
    <name>A0A654DWG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpB</name>
        <name evidence="3" type="ORF">MARINOS108_11012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="206"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="827" mass="92849" checksum="B9E36695A5F17951" modified="2020-04-22" version="1">MSFDPYKIDLPITEVIDEVKAHLTANNTLIVNAPPGAGKSTLLPLTLMQEDWLKGQKILMLEPRRLAARTIASRMSELIGDQVGKRVGYRVRFDNKVSESTKIEVLTEGILTRMIHADNSLEGVGLVIFDEFHERSIHADVALALCREAQQVIRPDLRIMIMSATLDMPQLTMLLKAPSVVSKGRQYPVEVQYVGEQDLMLLPEMTARTIIKATKEHLGDVLAFFPGEGEIRKCEELLRKELKGFALHPLYGQLPQGKQFAAIMPDKSGKRKVVMATSIAETSLTIEGIKIVVDTGFGRTSKFDPKSGLSRLETVQISKDSADQRAGRAGRLSPGVCYRMWSKATQARLSEHRNPEIMEADLAALVLDMAQWGIMDINQLTWLTPPPKGALAQASETLHQLNALEHGRITAHGKKIHQLPCHPRIAHMLLEAEEADMLELATDVAALLEERDPLGREAGIDINLRIETLRRFRDENRLGRKFARIEKVAESYRRMFDIEVDNGPVDPFETGLILSHAYPERIAFARPGNNAQFQLSNGKYAMAGHKDDLAHEPWLSIAHMDARDGMGKIFMASPLNPRDLAPLVKEREVITWDTKRGGLIATKDLRIGSIILQSKPLPDPDESHLVQAISEALKKEGGHLLDFNESVQQWQNRVLSLRKWNPQGNWPDVSTPTLLMTNGEWLTPYLDQVKKPEDLKKIDLTKVLHHSLSWELQELLTQLAPEKIEVPSGSYVSLQYRADGEPPILAVRLQEVFGLADTPKVNGGKNGVLMHLLSPGYKPVQITSDLRSFWDNAYFEVKKDLKRRYPKHSWPDDPWSAEAVRGVKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY8</accession>
    <name>A0A654DWY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="70" mass="7378" checksum="BB82D5EBC7908CD4" modified="2020-04-22" version="1">MSTLKFKTTIKCSGCLANVTPHLDAAEGIAKWEVDILNPNKILTVETAGASEAEVIAVVEKAGYTAEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX43</accession>
    <name>A0A654DX43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="5">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="4">
        <location>
            <begin position="182"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="408" mass="44189" checksum="A264DCD91C3A27AE" modified="2020-04-22" version="1">MADKMKSGFAELARERSMYPQEAPAKIKRGSKSLFIGVPKEISLQESRVTLKPESVEVLAANGHEIWVEAGAGKSAHYSDREYSEAGAKIVNSAKEVFKANIILKVEPPTLEEIEYLNDGATIISAFQSGRQSVEYIHALNAKKITAIAYEFIEDKVGGLPLVRAMSEIAGSAVMLIAAELLSNTNGGQGVILGGITGVPPTQVVILGAGTVAEYAARASIGLGVDIQIFDNHIYKLRRIKHALGQQIHTSTIDNATLEGAISKADVVIGAIRAEKGRNKCVITEEIVAKMKSGSVIIDVSIDQGGCIETSEMTSHKKPTFKKHDVIHYCVPNIASRVSRTASIAISNIFTPILLHVADAGGVDEMIFNHPWFMRGVYTYRGSICNIHLARKFNLGYKDLNLLMAARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX54</accession>
    <name>A0A654DX54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="165" mass="19742" checksum="37FA063205FE3574" modified="2020-04-22" version="1">MLYQDKYFDQDKNSILRAAQGFVEPQLLQRWVEIAFDSYMALENPMGLVDDFILRLKSIEKYDTSLLEELYEILAAIYRYEKGNNQLEIIWDGRSHYEVYAENWSESFEKWVQYFCTQPEIYRAILKACILQQGTNTKFLYYGMRKTILGHFNLRITRNKTLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX67</accession>
    <name>A0A654DX67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011622">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07696">
        <property type="entry name" value="7TMR-DISMED2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="7TMR-DISMED2" evidence="4">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="7TMR-DISM_7TM" evidence="3">
        <location>
            <begin position="172"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="599" mass="70772" checksum="FFFE00A0ABE438A2" modified="2020-04-22" version="1">MIYLWFHLLLYAAPVVIAPGTHELQLKIRDIEFYEDRFTTLTFEDVSATDFQTKFNKNLNFTPQDYNTGSAYWMKIKLVIPEGETNYLLEFFDQTIDTLQVYLSHEGKPFKEYVMGDMLPFKEKPMAHKNFEIQLTGSGEYLLYFRVVSHEYADIRVGIRSYNRFVEYALAEYYLYGIFYGMILIISLYNMLIYSAMREIKYLYYTFYIISVGVFAMSVDGVGYQYLWRNSPEWNQVAHGVSLFAIIFWAILFSKKFLSLKIRAPKINTLLNVVFGLRILLFGYALFFDHSIFQNRNIELIPLIIIFAGSISVFNRGYKPARFFIVAFGVLFLGFILKAMLMLSFIPFTTLTYYSLHICFVFEMLFLSFALSDRVRILKENRDRAHKRIILQHEENAKLKDRMNAQLESLVEQRTAELKEKNTLLSQQKVEISEINSLLDLDNWRLRNNIKSIQMERLQNKELTYREFIEVFSDKNDCLRALSNLKWRSHYSCARCNNTVYSEGSAPFSRRCSKCGYQESPTTKTLFHGIKFPLEKAFYILYDSFNKDQYSLVEFAEMLELRRNTISDFKKRIKALTEEEKRTLHEIFKNLEDFVSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX86</accession>
    <name>A0A654DX86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="148" mass="16617" checksum="214ED5820A91BE93" modified="2020-04-22" version="1">MTDNRKIKIRPYVIYLFVGMFVMFALNKVLLRPYVLQNDLPNALQVIVLSFPNFAEAIMGTMVLTGILFRVKHITLHKVTFLRPGHVFLTAAVLAAIYVISGELRVHGLGNNNTYDPNDLIASVIGLNLAYFTVRKFGFATIQESSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXC9</accession>
    <name>A0A654DXC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="5">
        <location>
            <begin position="420"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="474" mass="54624" checksum="971AD703D38FE918" modified="2020-04-22" version="1">MQVKDLVRIFVKGGIISPGDFLKTLLVAEKLGASHLHFGSRQDILFAAKEKSKAILDETFQSIHTEYEINTFEYQNILSSYVSQDILPGKQWLASHIYHYILNGFNYRTRLRVNVVDPSQSLVPLFTGQVNFIASNLENYWYVYLRLKRIQDTPWQMPLLVYTEDLVKVAQAIENEHLHERADTYQEIFTFLTENVQMNTQPVTENLVLPEPHFPYYEGINRLADGKYWLGLYWRDNKYRISTLKAIMERCIETEVGKVTLTPWKSFVIKGIFEKDRIGWEKLMGKFGMNLRHSSLELNWHLPALDQEALDLKFYLIRELDKQDISTYGLTFTIKTSPDIILFTSVVIEKSESGVSESYNILFSKNFNPNLTDYHYYARDVHKSVLASLILELSLVYYENLDEEKAVSPKVKSIIDNIQKELYQCVHCQTVYDSEFGDPEAGIKPGTPFAAVGADYICPTCGGNKEGFTKMSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXG3</accession>
    <name>A0A654DXG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="32844" checksum="8B9D6E6BBFB8D353" modified="2020-04-22" version="1">MSALVFVEIEEGAVKKSSLEAVSYAAQVDGSAVAIVFGALSDDEASKIGAAGASKILHASDEKLATPNIMAYASAIAEAMEKESSSLLVLAKSSLGDPVSARVAIKTGASLATNVVDLPDTSGGFKVKCSIYTGKAFAMTTLSGDKKILGLKKNAIAIKEDGGSASVETFSPTLNDADFKVKVTSREKATGEILLPEADLVVSGGRGLKGPENWGMIEELAKTIGAATGCSKPVSDMDWRPHHEHVGQTGVKVSPSLYIAVGISGAIQHLAGVNSSKYILVINKDAEAPFFKAADYGVVGDAFEVIPKLTEAIKAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS7</accession>
    <name>A0A654DXS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032267">
        <property type="entry name" value="DUF4832"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032379">
        <property type="entry name" value="DUF4874"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16116">
        <property type="entry name" value="DUF4832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16173">
        <property type="entry name" value="DUF4874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4874" evidence="2">
        <location>
            <begin position="52"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4832" evidence="1">
        <location>
            <begin position="236"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="460" mass="51817" checksum="0DE22D10E873FB5A" modified="2020-04-22" version="1">MTNLYNRILPTMLLFLSILVGCKDKDPSPASNPDTNISNTVHYTPSMESFPNPERGFLHLTAAFSEGSPLAQSSLQSLRNDNISLVWRLYYFEKFKQIDLSQAQLDLIQTDMDNLRSAGLKCVLRFAYTNNSDDGTDAPIEVVERHLDQLQPLFEANADVIAFVNAGFVGLWGEWHSSTNNLTDLANQKRIVTKLLEVIPSEIKIQLRTPRQKRDIFGEQTAMTDEVGYSDADIARVGHHNDCFMASYDDYGTYDNPNTDKNYISQEAFYVPTGGETCPPSGVDAADCEEARETMSLLKWSYLNLDWYKPIIDGWKSEGCFEEFEQDMGYRLALDSTTIDTVVSKSTPLDIAIYLYNHGWAPIYNHKTVSLVLSPASGDPVRMVLDVDIRKARPGASFNIAETIDLSDVPTGTYALHLHIADQFESIAERPEYSVRLANENVWDSHTGWNDLFQTIEITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXV0</accession>
    <name>A0A654DXV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="38802" checksum="EE20F55C3344541F" modified="2020-04-22" version="1">MKKLELLLTFSLLMLLVACKKEDFYQGDHFFVKNTGAEMPVYVKGNIQSGTFILFLHGGPGGNASLPSFMPVSKELESDYAFAYWDQRGSGLSMGNPDQKTFTVEQFVDDLDLVVEAIKLRYHHPRIVFYGISWGGALGCAYLSTKDYQQKVDGFICMDSGHNLVDGLPKSVVFVKEYAQRQIDHGIDVEYWTEARDWCATQPDMTKKENYFKYDGYLTNTNAYRKDPNQVVQGPEVGATGTMNSYLSLAIFFNGQYLVPRFNILELNLSEDMAKIKTPSIVIWGRHDGVNTIEMGYDAYHSIGGPDFQDKELVILENSAHEGYIEEQDLFIHTFRRFVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY09</accession>
    <name>A0A654DY09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024213">
        <property type="entry name" value="DUF3822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12864">
        <property type="entry name" value="DUF3822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="34366" checksum="1FDFD653AF99D652" modified="2020-04-22" version="1">MTKTATSNFKLIKRIKAGSFDESKLPSYSLCLQIGIRDFQFCVVNKQTGTCLVMEDYKLENIKTINTRLEVIKEIVNKHSFIGSNLWDNIKVSFKTHKFSLVPGSHFLPEASSDYLAVNSEIKTKIEEVYYYKHIASSAVNIFACDKKVISWSKERYPNKSLQVIHQGSALIEGVLKYDDHSKEKTMFTYFDRGILHIMVSQKNQLLYYNQFAVRKSEDYLKYIMLVFKEIGLSPKTSSLVVWGLLKNDAPQIELLKKYIRNISFGTKPNFLKFPSEFEDIADHRYFDLYSIFLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY66</accession>
    <name>A0A654DY66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024815015" evidence="5">
        <location>
            <begin position="22"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="7">
        <location>
            <begin position="96"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="6">
        <location>
            <begin position="368"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="538" mass="59313" checksum="575598D96FD0C159" modified="2020-04-22" version="1">MKRTYLNSILFALIMVFSTMSCEDLEERPVGTLSPEGLFVSVKELKAGVNGAYGQLAREEFHGRKLTLALLLRSDMVGIGDPSTPTRRHACDLMQMEQDNGLVDAFWTVGYRALAAANEVINAKDNVDGSEAEINAVAAQAYFLRAYVHFVYVRLFGEIIYMDGQPIDDPYAVQQSSVSDIYEGIIADLDFAKEWLADIPVDRSHPGKAAAYGMQASVYMTRATSDVAQPDDWQNAFDNAKHVIDNEGKYGVALDNNYYDIFAPDFASSEILFNITFIANDNHNITPGELGGSNAGTDQVTSVTGPRGDERFAALSSDAFGWSVAVPELSVYNTWDGRDYRKAVSLDTAITYQGVPDYRFTEWDGISQNVARPHIAKYFRAVGEAGLRTSTPQGASLRDSNSKQIILRYAEVLLIAAEAAVELGNNGAAVEYINRVRARARNAAGAGHSKYPPSPVPADITGAVTIQDVMEERRLELAFEGVRWYDIVRRKMGNVYSGAAPALENRDFDPNVDYLWPKYYVDVDLLEGLKQNVGYEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB5</accession>
    <name>A0A654DYB5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3857 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3857" evidence="1">
        <location>
            <begin position="41"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="615" mass="71412" checksum="A702A2BB0B7A65BB" modified="2020-04-22" version="1">MKLAGFLLLILLLRPILLISQANITVHQESLEYVIKRPGDANLKVTKSFTVHNIKGLESAVFTLYHDSFRKLKNFKFEMTNDRGERIEVYNIRDLLDLSLSGYANVTDSRVYLLDSKYKKVPFRVHYTYEMDFSGFISLDDWQPIKDFNTIIEESKISVKYPRDMTFEVMAVLGMKEPETYCDDGFCHFKIEYKNIKPISKKRYDEPLRDQTPRLLMKSNDFQLDGIDGSLASWKSFGDWYLKLNRRDEQITPKTRSDVENIRNSFDMVPELVDSVYKYMQSRTRYISIQLGVGGFKSLPAEEVDTKGYGDCKALTNYTQELLSIAGIKSYQVLVMAGSNVPRLIEDFPSNQFNHVFLAVPHENDTLWLECTSQTMPSDYLGSFTDDRKVLWVDQGNSQIVKTPYYSVEQNLVLEHVKISLTENGHAKIEIKITKGGNYFEEGQSYLYQATEEIQKSNQEKFSFSQYSIDHFAFEMDQDSLLLKEVYVLNVPSFAKKYGSRLVVDMKDFVKTSRISANTSDHFMRLLRNYQVVQTIEIIFPENHILQHANENLSIKKEFGEYELKVKRSPQGVQYYKKLILKKGDYSGDEFIELQEFMNGVFKNEISKIMLSSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYB9</accession>
    <name>A0A654DYB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CcoQ/FixQ family Cbb3-type cytochrome c oxidase assembly chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="63" mass="7438" checksum="4A99413A89D3B379" modified="2020-04-22" version="1">MLKFVKHHMETIAGIEVFPLISLIIFFVFFLGLFIYVLRSNRKQIDEISRIPLNINDESDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYC6</accession>
    <name>A0A654DYC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="931" mass="106499" checksum="C376EF63AEED49C8" modified="2020-04-22" version="1">MNVLNLSLNFSYDLAGNMMLHTMKRFFAVTSLIWCLGIYTQAQIPLPQNLEDGYPRIYITQSEKKELEQLISKEQWAQDVLAGIHSRLDEHVERHVGDPEWMVSRLMMYWKTRSSNVYVNGIYYSHADGEVPVPTVRYTGSRDYTTDYVMPDLEDIIPYMDDERGLYLRNKTKEGKPLEWVAQAETGGIIHRHNQRIIGLAKDAAFVYWLEGGERYARFAMDIFDTYMMGMYYRSEPIDLLNGHIQTLVGLTCFQVIHESTLIEVAELYDFLHRYIEQNHQEKISKYDATIKKWNDLIIKNGVPQNNWNLHQAKIILKAAMVLQSNGHYTDGKGREYYINYILNETSARQWSLNKFLVYGYDFENGVWAECPGYSQGVTKDLTHFMVDFYNTFDHNLLPYMPVMDEAVQMLPQYLFPNGQTVAFGDTYYGPATTEPMSDMIRIAQKNGDQQREITYTAMYRLFGEGQEGKKSQKPRAEIASFFASSPLELNPKYEAGNRGDYLTQTFYAPNVSWHVQRMGEGQDGMMVSLNGSLGNHMHANGINMELYGKGFVQGADPGKGAGYLQPIYLEYYSQFPAHNTVMVDGASSYTEMLSYHAFDLMGEYPKSGQKEGYYPDITYSDVFFLEPETRSDQSRLVSIVKTGEATGYYIDIFRSKKQRQGDKFHDYYYHNLGQTMKVMDESDQTLDLTPSEEMAFAGGHLYALDYMWDKKSVKTDKDYQVQWKIDMPQGEEDVFMNLWMKGTDGREVFSIKSPPNKAFKEKGRLPYEVGEAPYLTFAARQHGEAWEHPFVSVFEPFTSDEGRSIASIDGFEDEKGSSDFVGIKVTHKSGREDHVFSSKDGKEAKHMDMSSDAAYALIGKEEEGGLIFFMGNGKVLKGHGYAITTENIGNVVLTYEDGKLMLDNEVTVRIGHGKRAKEFGAGGFREITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD2</accession>
    <name>A0A654DYD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="21330" checksum="FB8243CABC25BF27" modified="2020-04-22" version="1">MLRNNWFSAFALLILTTWTTGCSDKDVPDAENEEEIITKVQLIFSPTEGAPVVVTALDPDGDGPEDIAPSGPIVLAPATEYELFIKLENTISDEDITEEVEAEGDEHLFFFGFSEGIFESPTGDGNVDQRADVVNYLDKDVDNLPIGLITAWITGESGSGTFRVMLKHQPGIKSATSESTDGESDVDITWTLNIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD7</accession>
    <name>A0A654DYD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="223" mass="25173" checksum="31437D10D75E426A" modified="2020-04-22" version="1">MIKVALADDHEIVRHGIKMVLEDDPEIQVIWEASDGQEAVEKMDSDAPDVLVVDIRMPLMTGLEVTHQLKKNNDEVKIIVLTMHDDSEYIVKALEYGADGYLLKDTNKAEFNKAVHMVHNGQKYFSGDISTTIVDFYRNGGPRPGTGSEPGGSNSEDYQLTKREKQILKLIYEGVSNKDVAETLGKSVRTIETHRFNIMKKLEVNNITELLKKVEREGLDKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ54</accession>
    <name>A0A654DZ54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025041117" evidence="1">
        <location>
            <begin position="38"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_lyase2" evidence="2">
        <location>
            <begin position="57"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="549" mass="58068" checksum="B2AB137609FE9A98" modified="2020-04-22" version="1">MNLTTTLNSIWVRLSGPLMVGLFALSACLLINNSATAQTYSAPYDIPRFQAFMGECKLQAPTSSTMATQSDIINGFTNSNFYVADGDKVAFNQSGGSQRTELRDLRNWDLTVNDQQLFGRIDIVQQTCDQVTVMQIHDDANAGNGPNKPLLRIYKHQTKSPVNHIWAAIKTDAGGQATTHIDLGADPGGYFDCEIQLVGGNMIIKFQGVEKVNMDVSYWDWPSYWKAGVYLQDNGEATAHFDELYEGSGGGTGNSAPSVSITSPSNGATFNNGDNVSISANAADSDGSVSQVEFFVNGSSVGVDTSSPYSINWTIGVGSYDITAVATDNASASTTSSVVSVTGTSSGPATNTYVSAIVTGTQGAGKGKKHGTATVTILDNNGSAVANATVTGTFSGTFNETVSGSTDSNGTVELVTSSTAKGGVSVNLCVDDVTHASLVYNSSLNVVTCAGASARLGGPLDESKKDVALGIYPNPTFSSFTLDIMLDKESFFDGRLLGMDGRVLRRIEPHILSQGNHQLQVDVDGLKKGVYFFEYTLDGKTQTSRIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ62</accession>
    <name>A0A654DZ62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_110122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD15974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="71" mass="7611" checksum="463657796046FB5D" modified="2020-04-22" version="1">MVSPLRTVIPAQAGISFSQGSRFAGGIVLLFNGVQSDNAWLVTQPPPSDNAQRHFAVKMSAKIRITMPDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX1</accession>
    <name>A0A654DZX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MATE family efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="468" mass="50696" checksum="13F633E72A61838D" modified="2020-04-22" version="1">MSGAISKFLRIFKLFIAALKGTESEFTSGSINRAIFLLSIPMIAEMVMESLFAVADVFFVSRVSVNAVATVGLTESVLMIIYSVAIGLSMATTAIVARRVGEKKFKKASDAGFQSIFLAVIIGALLGGVGYIFAEDILVLMGGKPDLIAEGLGFTQIMLAGNLSIFLLFLNNAIFRGAGDAAIAMRALWLANGLNLILDPLLIFGWGPVPAYGVEGAAIATTLGRSIGVLYQVYHLMNRRGIIKIGWANVVIRFKTVVELLKISLGGMGQFLIESASWIFLVKVMSLFGAEALAGYTIAFRVIVFTILPSWGMSNAAATLVGQNLGASAPDRAEESVWKTAFYNMIFLGLVSVVFYLAAEPIIGIFTVQPGVVKIAVSALQIICFGYVFFAYGMVISQAFNGAGDTRTPLIVNFFVFWVIQIPLAYWLSVYLDWQANGVFFTIAFCHSLQAVISILLFRRGKWKTMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZX4</accession>
    <name>A0A654DZX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024985827" evidence="1">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="21847" checksum="33D35C58D9267EF5" modified="2020-04-22" version="1">MKHSIKHVLALLTVFSASVAYSADSAYMATICKVVAEEDKLYKVIYQAANEENVTIQLFDEKQHLVYKENLKSAGFSKKFDLTNLPDGDYQIQVKSSGYVFSEDLKIGDISSFVFSFDQKADRKIAMVGAKEQGKSLTLYILDEARDVVYKESFDQDNQVHKSFNFQSLKSGDVTFLLYHDSKLIKEEKFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E020</accession>
    <name>A0A654E020_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_120002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024825320" evidence="1">
        <location>
            <begin position="21"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="360"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="592" mass="65132" checksum="CC1F110AC1C1F653" modified="2020-04-22" version="1">MKRSILIIALIFAVAQYTNAQAPDSFAHPGVLSSQVELDALKEAVQTSNGHPQVAGYARMADETLGNLDYTPTPYANVHVIASGVGDEERAFRQDAHALYIHAIKWVVTGDDAHRDKAIEIADAWGDTFESLIPEENKPNQPTLEASWALPIWIAGAEILKYYDNGVSGWSSASFETFVQKVLVYVNGPIYQTANWLISKDLSLMSAGVFLNDAALYNEGYNHVTGQIDDISTTGQIPELTRDFVHSQYVLIGLAQCAEVAYQQGDEGLFTHSDARLRTGAETYTLSVLGQTSPSYHSSSEWARHSAPYEILLKRYTELELPVPVVQYYVIAQNRPEDGSEDHFVGWLSATHAIEAEAGEAPVSEGQEEVPGNLAFNQTASASEVPQPENPPAAAIDNNTLTRWSAQVYPQWLEVDLGEVKAVGKTEVIFYEDRAYKYFIEVKKSEADAYTQVVDRTANTTPGSVEAPITDEFSPTQARYVRITVTGASGYTGAWVSLTEFRIFEGDEVILGIGDKGRFNVFPNPVSDTFTVEEAHEQVVVLYSLSGVELMKKSAGVTKHFDVSGLPAGLYFVKILSTDQKVIETRKLIKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E060</accession>
    <name>A0A654E060_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">MARINOS108_120042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="238" mass="26691" checksum="0A1248E5F4BE3519" modified="2020-04-22" version="1">MMKERKEIFATAKETAEAFGDYLMKEAGEKSVFHCALSGGSTPKMLFDYLAAKYRDSPLWDGIHFYWGDERCVSPEDAESNFKMTKERLLDYIPIPQENVHRVLGENDPEREAERYGQELLEYLPTHKGLPVFDLIILGMGEDGHTASIFPHQMELLSSEEVCRVAVHPDSGQKRVTLTGPVINAAHEVVFLVTGAGKKEKVSEIFNKTGEWESYPAAHISPVQGSLVWFLDEAAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0I8</accession>
    <name>A0A654E0I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018736">
        <property type="entry name" value="DUF2279_periplasmic_lipo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10043">
        <property type="entry name" value="DUF2279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024994795" evidence="2">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="33559" checksum="7174C7B8EC3343E4" modified="2020-04-22" version="1">MTSKVSKVILLLLIPFGLLAQEQNLNKKRFNTLLIGGGTLYTVSMIGLGSVWYQDFGRFHFFNDNNSWGYMDKLGHTTTAYQIGRLSAKSLAWSGLDHQQATWYGGMTGLFFLTSVEVFDGLSEDWGFSIGDFTANTLGSAAFISQELIWSEQKVMLKWSYSGSPYAQYRPELLGSSSSQRWLKDYNGQTYWLSTNLRSTIFQNASRLPKWLNLAVGYGIDGYTGGNSNPSENEAGQTLPEFTRSGQYYLSLDVDLTKIETRSNLIRGLLGALNFIKIPLPGIEYNPENGWKYHWLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0U7</accession>
    <name>A0A654E0U7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Gliding-associated ABC transporter substrate-binding component GldG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="30"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="501" mass="56082" checksum="7F44704A228D01CD" modified="2020-04-22" version="1">MNRKNIIIQLGIVLAIILVANLISNELYFRLDFTEDNRYTFSEATKEVIDELNGVITVKAYFSEDLPPQLMKNRQDFQDQLVEYENRSQGNIVFEFVNPNENEEAERDAQQNGVSPVMINVTERDQVQQMRAYMGAVLKMDDRTEVIPLVQPGAAMEYAITTAIKKVSIADKPKLGLIQGYGEPTLQALPQLMDQLSVLYKVEPFRLRDTAAVPGYYRALIWINPKDSVSPGDFSKLDRYLNQGGGIFIAHSSVEGDLQQGLLSKTTDVGLKGWLGRKGLVLGDQFVVDAQCASVNVQQRQGFFTINSQVEFPFFPMVNNFADHAITSGLESVMFPFVSPLSFGSSDTSWAQVPLVYSSENSGLITPPSYIDIQKKWAQRDFPQSAQILVAGLDNGKARVGVAANGTFCVNGEGQRPQQQNQDNINLASNMIDWIADDTGLIDLRTKGITSRPLESVEDSSKAMIKYGNVFAPILLILIYAFIRKQMNQRKRQKWMQGNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0V3</accession>
    <name>A0A654E0V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="14063" checksum="C09C514BBB2857EB" modified="2020-04-22" version="1">MIKPKALVQKWVDLFNTADAQGLANLYHDDAINHQVANEPISGKPAIYEMFKSEFAQAEMTCVVEQILEDGEWAILEWKDPLGLRGCGFFQVIEGKIQLQRGYWDKLSFLRQHDLPIPPMSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z6</accession>
    <name>A0A654E0Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name evidence="3" type="ORF">MARINOS108_120335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="PTHR43268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="126"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD16667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="321" mass="36843" checksum="628B4B0F0A83910A" modified="2020-04-22" version="1">MEAEYLNLLYYCYSRIEDPELFREQHHLKCLELNLKGRIIVASEGLNGTVSGLRADCEQYMKDVQSDPRFSHVEFKVESVPDHTFTKLHVRVKPEIVHASLPHIDPTKRTGAYVEPDEFRKILKEQPEDTVILDVRSNYEHEVGKFKNAITLDIENFRDFPEKVKELESLKDKKVITYCTGGIKCEKASAYLLEQGFKDVHQLHGGIIKYGIEAEGEDFEGKCYVFDNRIVKDLNKVNPKIISRCYVTGVPSDRMVNCANPHCNKHIPMSEEGARVYNGCCSEECAKNPDVRPYDGTGFYQKEMNGYNPYRGLKRQKSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E149</accession>
    <name>A0A654E149_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="11181" checksum="00AD57922043023F" modified="2020-04-22" version="1">MPAHKKHLTKSFHQRFAKITAGFLGGYAVTVSLFMALSLWWDRAGVMVTLIFGGFILWAGLMIVAFLFRNGWLAWLLYLVLATVFSAVFYFNQYTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G1</accession>
    <name>A0A654E1G1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="7035" checksum="1AF509BE4B562345" modified="2020-04-22" version="1">MKKPYRYALYFGIGVLIYFAMDGENNPESLEEVHKMAPALIIGVVVLLFLVRYIISKKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G5</accession>
    <name>A0A654E1G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aminopeptidase FrvX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_120460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="355" mass="39573" checksum="1EA12318E837D878" modified="2020-04-22" version="1">MDSKSKDFLFKYLNNASPTGFETSGQEIWLDYIRPYIDDYFTDTYGSVAAIINPEAKYKVVIEAHADEISWFVNYITDQGYIYVVRNGGSDHQIAPSKRVNIHTKNGVVKGIFGWPAIHVRKDKEDSPTLKNIFIDVGASSKKEVEDMGIHVGSVITFDDELMELNDKYLVGRALDNRIGGFMIAEVARRIKENGIELPFGLYVVNAVQEEIGLRGAEMIAHRIKPNLAIITDVTHDTNSPMYDKITSGDISCGDGPAVCYGPAVQNNVLDMIIGIAEKEQIPFQRRAASRSTGTDTDAFAYSNEGVASALISIPLKYMHTTVETCAKDDLENTIQLIYETVIQVKDGQDFRYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1K1</accession>
    <name>A0A654E1K1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4705" checksum="A4E15BF1D3D60EB8" modified="2020-04-22" version="1">MSGTGHKCPHTDNHETTGIPITTDYQSLKSMVCFLRKNLQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1M0</accession>
    <name>A0A654E1M0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-S-isoprenylcysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009915">
        <property type="entry name" value="NnrU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07298">
        <property type="entry name" value="NnrU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NnrU" evidence="2">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="190" mass="21365" checksum="84ED7A85D7F48243" modified="2020-04-22" version="1">MDYLIIGGGWALYFALHSLLASEQVKRTVRSKAPAIARGYRFFYSLISTVGLLWLLYLIAITPSATLFSPPGYVRYIAMILASWGVILVITSFRHLSGWAFLGLKKEEKKGLIRKGTHAYVRHPIYSGIILIVIGMALYTPTDIVVLSVVCILAYLPAGIYFEEQKLIAEFGDDYLTYRREVPAIFPKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1T9</accession>
    <name>A0A654E1T9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetrahedral aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">frvX</name>
        <name evidence="9" type="ORF">MARINOS108_120258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="350" mass="38695" checksum="165A3D0184EAF4C6" modified="2020-04-22" version="1">MKVDVKLLKAICEAPGAPGFENPVRQLIIKEIQAHVDEYSIDNMGNLIAIKKGVKNPEGKKVMVAAHMDEIGFLVSHIDDNGFIRFQTLGGFDPKTLTAQRVIIHGREEVIGVMGSKPIHVMKAEERNKPAKIEEYFIDCGMSKEEVEKWVTIGDPITRQRELIEMGNCVNCKSIDNRVSVYILIEALKQIRNPAFDFYGVFTVQEEVGIRGANVASHTLNPDFGIALDTTIAYDLPGAQAHEKVTELGKGTAIKIMDAMTICDSRMVKFLKKTADSHQIEWQPEILAAGGTDTAGVQRMGKNGSIAGAISIPTRHLHQVIEMAHKDDIIASINLLVYALEEIDTASWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1V0</accession>
    <name>A0A654E1V0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stearoyl-CoA desaturase (Delta-9 desaturase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_120268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="30708" checksum="4817C2C122715A98" modified="2020-04-22" version="1">MAVIITFFIAHWYLSLFFQTFFLHRYAAHKAFTMSPFMEKVFFVLTWLFQGSNYLSPYGYGVMHRMHHAFADTENDPHSPKYDETIFKMMWKTKSIYSDITNKKVDVDKRFTEGVPQWHAFDKFARSWVSRLFWATSYFMVYWFYADVWWLWLLLPAQWLLSPIHGAIINWFAHIYGYRNFEVGDTSKNFLPLDFLMMGESYHNNHHKHGSRPNFGGVRWHEIDPTYQVIKVLNAVGVIQVAKQKTVKLEKTEKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A3</accession>
    <name>A0A654E2A3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_140167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="316"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="419" mass="46377" checksum="5E357DCE2971DA3B" modified="2020-04-22" version="1">MFDQDKWEEIWQTIMKHKLRTALTSFGVFWGIFMLVLLLGAGNGLQNGVMQNFDIAKNAVFVWTEVTSVPYAGFQAGRSIDLTNDDFKALQNIKGLHTVSPRIPLNSRWSGGQVTISYDNRDVSYSIMGDYPQYLDIQPLWITEGRFINKFDIEQKRKIAVLGRRVKDDLFQERRALGEHIKINGVPFKVVGIFDSRATGEDARNDIQIIHIPGTTAQQTFNMGESIGWFGCIPADGISGLEAEEIIKAELRKRHKIAPNDRQALGSFNVEEEFRQMQGLFTGIAAFSWLVAIGTILAGMIGVGNIMLIIVKERTKEIGIRKSIGAKPWSIISMIVQEALVISGVSGYLGLVFGVVLVEGIAYAMAEFGMQSEFFVNPEIDFKAAFSAISVLLISGVIAGLIPGIKAARVDPVIALRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2H5</accession>
    <name>A0A654E2H5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">MARINOS108_120488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD17113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="10023" checksum="B662524354838AAA" modified="2020-04-22" version="1">MERNLRKERVGQVVSNKMQKTITIKVDRKVKHPIYGKFIRKTTKFSAHDENNDCNIGDTVRIMETRPLSKNKRWRLVEILERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2K9</accession>
    <name>A0A654E2K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-carotene hydroxylase</fullName>
            <ecNumber evidence="5">1.14.15.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtZ</name>
        <name evidence="5" type="ORF">MARINOS108_20116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.24" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045019">
        <property type="entry name" value="BETA-OHASE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31899">
        <property type="entry name" value="PTHR31899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="158" mass="18746" checksum="AF13C937F1E0CF1C" modified="2020-04-22" version="1">MNYFIHTALVVGTFLLMEAVAWATHKYVMHGPLWSWHRSHHKKHPHALERNDLFALVFSAPSILLIVAGFELPEWAFLKYVGFGIMGYGLFYFVFHDIIVHRRIDIPYKAKNKYMKRIMKAHYVHHETHTKEDAEAFGFLYAPKKYEAKEDQTIRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L9</accession>
    <name>A0A654E2L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimP</name>
        <name evidence="6" type="ORF">MARINOS108_20502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17619" checksum="02A2E28DBD1A102D" modified="2020-04-22" version="1">MVVVKPVEEEISQFVHEIISDDPSLFVVGVILKGNAGNQRLIVLLDGDHGVTIDQCSSVSRQLAQILEEKELFEDKYFLEVSSAGVDFPLQNVRQYTKNIGRSLKVELNDASTISGLLKEVNNEMIMIEVQEKKELRQHQINFNEISKSMVLVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T8</accession>
    <name>A0A654E2T8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="150" mass="16966" checksum="3BC75C34804F1DA7" modified="2020-04-22" version="1">MLLKDALNHFRNLESEATKKSEVRIYQKFIQVLTRLEDRDMSDDEVQSIEEALDAFDLNSTTTHSNRHWNKVFRQFEQFLKDTFSLTTKGYYTRLGMGLGASFGIVFGVVFFSDLERSLGISSGISIGMVIGLIIGRTLDSRAMASGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2U4</accession>
    <name>A0A654E2U4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="2">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="PTHR34983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025094192" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Por_Secre_tail" evidence="3">
        <location>
            <begin position="600"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="667" mass="72784" checksum="95D8A878D3C8FEC9" modified="2020-04-22" version="1">MKTSFTTLLAILIYLSVNAQTFYKGVDLSYVNQMEDCGAIYYDGGTAGDPFQIMADHGANIVRVRLWHTPEAWTAFPSSYSGYNDVVTTITRARSRGMSVLLDFHYSDTWVDPGKQAIPSAWASLVNNTPALETKMYDYTYQVLSDLDQLGLMPEFVQVGNETNGSMLFPEGANIYPIDWNRQSAIINAGIAGVRAAGNNSTIQPKVVLHIANPVHGDGWFGSAVANGVTDFDIMGFSLYPEWHGGNIGQTGDIVEYLRTTYNKDVMLVEVGLPWTDASNDAAGNILSQMPSGYGVPSPAAQRNWLVDITTEVHNRGGIGVIYWEPAWVSTGCDTEWGTGSHYENATFFNFNNELITDGGVQFLEQSYGAGVNNVTFSVDMTGVTGANGAYVTGNFTGSGSWQIIPMVNEGGNIYTYSTSIPVGTTGAYYFLKSNTWGDRETVPAECALQWGTDREYTIQAGQNVLAFPWGSCTPMTERTVTFRVDMTGVNGAQGAYVTGDFTGANWQILSMTHEGNNIYSYTTTMEEGATGGYYFLKRNKWSFRETVPSECALAYGTDRQYTITGTNNTFAFGWESCDQASARVVTAIGLPSEGQELSVYPNPVADVLYLENSSYRQYSLMNLSGATLLSGTLSRTDQISMDGLPKGIYILRLTGAGTEVIRVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2X7</accession>
    <name>A0A654E2X7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ORF">MARINOS108_20290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD18553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="27403" checksum="E1AA8C0EC3DADF2A" modified="2020-04-22" version="1">MRKNIAAGNWKMNLDLASGKKLASEVINMVNDEVQNDAEVILIPPFTHLTVVKQLIGSSTSVHLGAQNCSDQKGGAFTGEISTEMLQSVGVEYVVVGHSERREIFGEDNALLAAKTKAVLAQGLKPIYCCGEKLETREANQHFDLNKAQIEEGLFDLSKADIRKVVIAYEPVWAIGTGVTASSDQAQEMHQFIRGLIAEKYDQETADGISILYGGSVKPDNAKELFSQPDVDGGLVGGASLKSRDFTDIIKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E340</accession>
    <name>A0A654E340_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA-like transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="296" mass="32180" checksum="BA25A429C8B15C9B" modified="2020-04-22" version="1">MTQKPTVKAWSLLLALSLIWGSSFILIKKGLLGLTPFEVGSLRILSASIFLLPFVIRNLKKVKRHQVKYLVSIGFLGSFIPAFLFAIAQTRLESSITGVLNAMTPIFTMLVGLFVYKQQQSPRVFVGVFVGFLGAATLVMAGSGGELSNFNFYAFFVVLATIMYALNLNIIKHHLQELRSMTITSISLAFVGPIAAVQLVFFSDFPTRVMEVEGVLEATGYILTLGVVGTAIALIIFNKLVNLTDPVFTSSVTYIIPIVAVMWGVLDGEVLLLSHILGIVAILVGVYVANSSKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E344</accession>
    <name>A0A654E344_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="341"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="657" mass="72759" checksum="A08D4CAEDDDD5A33" modified="2020-04-22" version="1">MKFDRKTRSDKQLLAIYSELVTPRLIEEKMLILLRQGKISKWFSGIGQEAISVGAALALDKDEYILPMHRNLGVFTSRGVELTQLFEQFQGKAHGFTKGRDRSFHFGSKAHNIVGMISHLGPQLGVADGIALSRLLRKEPKATIVFTGDGGSSEGDFHEALNVASVWNLPVIFIIENNGYGLSTPSSEQFNFDSFVVKGPAYGIEAHSVEGNNILEVLNELEPLVESIRKNPRPIIFEAKTFRMRGHEEASGTKYVPKELMEHWAKKDPIENFERYLLKEKVVTKDELEKVKAKIRTEVNNSVKKAFAQPAIESNTQTELDDLFAPFEQEIVAAGSHTSEKRLVDAISDGLRESMEKYPELVIMGQDVADYGGVFKITEGFVEQFGKARVRNTPLCESAIVGTGLGLSIAGIKSVVEMQFADFVTCGFNQIINNLAKTHYRWGQNADVVVRMPTGAGVGAGPFHSQSNEAWFVHTPGLKVVYPSNPADAKGLLNAAIEDPNPYLYFEHKYLYRSLSGNVPDGYYTTEVGKAALAREGNELSIITYGLGVHWALEAIDKLGISADVLDLRTLLPWDKEAVAETTRKTNRVLVLHEDCLTGGIGGEISAWIGEHCFEHLDAPVMREASLDTPVPFAKALEENFLPKSRLKTKIQALMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E373</accession>
    <name>A0A654E373_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septal ring factor EnvC (AmiA/AmiB activator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024868041" evidence="2">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="299"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="397" mass="45187" checksum="9FA393097E6ADEFA" modified="2020-04-22" version="1">MIVSKRLAFFGFFVLLLASGVYAQKTKSQLEQEKRENLSKIAEAEKILSDTESEKKATLGQLRALNQQIEAREGLISALNQEVGLLNGEINDLSIVVNALQSDLKNLKQEYAAMIYSSYKANHGYSKLTFLFSARTFNQLYMRLKYLEQYADARKIQARQIEEVSRELDAQRNQVEIKRSEQKTLLNQQLAENRKLINLKTKQSGLVQELTKKEKELKKELADRKQAVDRLDNLIAEIVRKELERSKTLSSTAIANEDEISASFESNKNKLAWPVSSGFISSKFGKHPHPVMKGIMQDNPGVDIQTQKDESVKSVYDGKVIQIAYVPGMYNVVILQHGEYYTVYSRLKEVNVKKGTLVKRAQPLGAVHTDTNGVSEVHFEVWKNYAKLNPEQWLSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E378</accession>
    <name>A0A654E378_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="12228" checksum="AF184B40B6216D4C" modified="2020-04-22" version="1">MKEQSLGEFEELVLLMVAAHHDEAYGVLILESLEKKLDKKVNISAIHVALKRLEKKGFVTSRFGGITADRGGRRKKFYVISALGKSMLDKQYALRTSIYQEIPNISFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G0</accession>
    <name>A0A654E3G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system fused ATPase/permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030260">
        <property type="entry name" value="ABCB10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF553">
        <property type="entry name" value="PTHR24221:SF553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="349"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="590" mass="65115" checksum="87D6C96752C3CE58" modified="2020-04-22" version="1">MSKEERKKLNREGLKNLSGIFSYMWPYKVPFITGLVLLVVSSSLFMVFPFVAGKLIDIASGKQEWFIQNIGTAALLLLGVLLFQSIVSFFRVFLFAIVTENAMANIRTDLYQRMMTLPMAFFDQNRAGELVSRISNDVSLLQNTFSVTLAELIRQTIILIAGIGLIFYTTPALSIFMLATFPVIVVLAFVFGKFIRKLSKKTQDQLAEANVIVDETIQSISSVKSFTSELFEILRYRKSMGGVVKTALRVARYRAAFISFIIFMIFGGIVAVMWYGATLVQSGDMSVGDLLSFVLYTTFIGASIAGIGDLFGQVQKAVGASERILEIQNEDPEQDLSQPKSEVDLHGDIQFREVAFSYPTRRELPVLKGINLKIKAGEKIALVGHSGAGKSTIVQLLMRFYGVSAGAISIAGKNINEIDLTALRAHIGIVPQEVILFGGTIGENIRYGKPEATHQEITEAAQQANALEFIQSFPEGFDTLVGERGVKLSGGQRQRIAIARAVLKNPSILVLDEATSSLDSESEHLVQQALDTLMKDRTTIIIAHRLATIREVDKIYVLENGQVIESGTHAELLTEKGAYKNFIDLQLLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q8</accession>
    <name>A0A654E3Q8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ORF">MARINOS108_20541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="37431" checksum="B22849EC61468662" modified="2020-04-22" version="1">MGFFDFFNSDIAIDLGTANTLIISKDKIVVDEPSIIAIDKNSNKVLAIGREAMQMHEKTHENIKTIRPLKDGVIADFHAAEHMIRGMIKMIDNGNKKWLPSSHRMVICIPSGITEVEKRAVRDSAEHAGAKEVYMIHEPIAAAIGIGINIEQPIGSMIVDIGGGTTEIAVIALSGIVCDQSIRVAGDSFNKDILDYMRRQHNLLIGERTAERVKIEVGSALTELDDGPEDYEIRGRDLMTGIPKVIKISYSEIAFAIDKSVSKIEEAVLKALEISPPELSADIYDNGIYLTGGGALLRGLDKRLSMKTKLPIHIAEDPLRAVVRGTGLALKNLNQFKPVLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E435</accession>
    <name>A0A654E435_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="4936" checksum="B5B900F7C5A075B6" modified="2020-04-22" version="1">MFLGEGFFNDSIRVERVYPGAVKTGKFNGYVLFAECSALYSSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E464</accession>
    <name>A0A654E464_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="295" mass="32548" checksum="2F6926F03DFBECF5" modified="2020-04-22" version="1">MTIGVDLGATQIRAAICQGDRLEHKRQTLLENKDVLEKTLDQISDFLSPLINSNTDGIGIGVPAVVDIPTGTVYNSNNISSWKRVELKRELEMRFGLPVHVNNDANCFAYGAYKYGLEVRCENMVGITLGTGIGIGLVLNGRPYFGSNCGAGELGILRYLDARYEDFSSSGFFVTQHQTTAQAANEAAAGEHGEVTVWREYGHHLGQFVKMVLAAYDPEVIAFGGSISKAFPLFEGDLKSALSDFPFQETVRRLKLVTIDQQDLAILGAAALWDEYERLDRSALDWKRRSEITHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E483</accession>
    <name>A0A654E483_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_50080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="274"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="404" mass="44205" checksum="74915711C2682515" modified="2020-04-22" version="1">MPILHGPFRQIIALWDIPLKGKIQNEELTVIEQGGVVVEDGYIVNIAPFSSFDVRDYEYHPIEEDMVLIPGLVDCHTHLVWGGSRYQDYTMRTSGRSYQDILAAGGGIFDSVRKTQQAESEDLLQNLIRRADKHLNEGVTTIEVKTGYGLETAHELRLLEVIRDAKSVVKADLVPTCLAAHVCPKDYEPAAFLAYLENELLPQVLVRGLSKRVDIFVEDNAFPEPLARPYLSAARKLGFELTVHADQFSVGGSKLAVEMGAFSADHLEASGENEIKALATSDVISVALPGASLGLGMQFTPARKLLDAGVSLAIATDWNPGSAPMGDLLVQTSLLGVYEKLTAAELLAGITFRAAQALNLKDRGRLAIGERADMIAFSLKDYREIFYHQGSVKPSLVWKSGQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E497</accession>
    <name>A0A654E497_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_50100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="378"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="617"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="732" mass="83699" checksum="6B0EE1B8DF4FFE1F" modified="2020-04-22" version="1">MYQTNVNDAQKVTRLLVEAYDARVNDLSKSVMLAQEALEISQRLDEAILIARSLSRLSLFHMILGEYKKTMKLGKKALGYFQILGDEKGIADVKYNIAGVYYRTDNYHLALIYLIDCFEIYQKLNDFHNQSRVQKSLGTIYEYFGDQKSAILSYEKAIKAAQMAGDLNLESNAYNPLSGIYLNRDEIDQASEMIERSYQMKQETGDVRGLAFCLYGRAKVYVKRKQYQLAEETFLEAVRIHVEMGERLGRGMCYHKLGQLYLEMGDLGKSEKMLDEALDFAQEYNMVIIKINCNYLKYQLYRQKDDAVQALKYLEIYLKEKEAVMNTQTQKVIESYEAVTKMERLQKEAQMNREKAEILKKKNRAEESSRVKQEFLSTMSHEIRTPLNAVITITSLLEERSDKEENELLRSLKFSADNLLRIINDILDFSKLDAGKVVLEPQPVEISLLMENIRNTYLGMAREKGIDLKLTVDPLLAEVYLADETKLSQILGNLISNAIKYTDEGQVNVEVKLLDQGESRDQIEFRVEDTGGGIPENFLEEIFESFSQPRSYTTKKQGGSGLGLAIVKKLIGLHGSNIHVKTQENEGSVFYFQVSFMKGERKITPSHQESDGLTGRTVLIAEDNMINAMVALKLLANWGVKATHARDGSEAIQMSSECKYDYILMDIHMPEVDGFDAAKTIRESENPNLETPIFALTADITAHQREVFEPYFDGFLLKPIEREKLYQTLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I1</accession>
    <name>A0A654E4I1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="3">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">ispG</name>
        <name evidence="4" type="ORF">MARINOS108_10900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017178">
        <property type="entry name" value="IspG_atypical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037336">
        <property type="entry name" value="IspG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="661" mass="73460" checksum="D89BA6B1A8F4E545" modified="2020-04-22" version="1">MNPADELLTGKVNFCDSLTQYKRRKTREVYVGDVPMGGDNPIRVQSMTTVDTMDTQGSVEQVLRMVESGCEYVRITAPSIKEAENLREIKSELSKRGCFVPLVADIHFTPNAAELAATIVEKVRVNPGNYADKKRFEEIEYTDATYNAELQRIREKFTPLVEICKEYGTAMRIGTNHGSLSDRIMSRYGDTPLGMVESALEFIRICEELEYFDIVISMKSSNPQVMVQAYRLLVQKLDEEGLQPYPLHLGVTEAGEAEDGRIKSALGIGVLLEDGLGDTVRVSLTEAPEVEAPVGQILVDRLAGRQGHAPIANCDFSAYHPYEYQKRQTNEVINFGGGNVPRVIADFSDIESVEMKDLKAIGHFYLPELDKWTMNDLGCDYIYTGTRPIPFMLPNGLKEILDYDTWLTVNSDANKYPLITVNEIDKPIDSKCIFIQLSTTELTPSVIEKIRQMTNAVLILKTNNQHAYADLRQSFVGLVNAGVSIPVVIERSFPDLNADAMMMYPATDIGGLLIDGFGDGALLSMAQVKRDRSERLAKAKLYNSTVFGILQAARTRITKTEYISCPSCGRTLFDLQETTAMIRKRTDHLKGVKIGIMGCIVNGPGEMADADYGYVGSGKGKITLYKGKEVMKRGVPSARALDELIELIKEDGKWTEPQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4J4</accession>
    <name>A0A654E4J4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YknY</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yknY</name>
        <name evidence="5" type="ORF">MARINOS108_20736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="237" mass="25988" checksum="9C0AAB2742819ED1" modified="2020-04-22" version="1">MSLIIDTKDIKKSYVMGSETIHALKSISIQIERGEYVAFMGPSGSGKSTLMNIIGCLDTPSDGTYILNDHDVSDLTENELAEIRNKEIGFVFQTFNLLPRASSLENVALPLIYAGYGKEDREEKALAALDGVGLADRAQHKPNELSGGQRQRVAIARALVNDPSIILADEPTGNLDSKTSYSIMDLFADLHQKGNTIIMVTHEEDIAEYAHRIIRLRDGLIESDEVNKNVRSTVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4M9</accession>
    <name>A0A654E4M9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">clpB</name>
        <name evidence="12" type="ORF">MARINOS108_60111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="397"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="871" mass="97629" checksum="FBC6BFA801C1ABC2" modified="2020-04-22" version="1">MNFNNYTIKSQEALQKATEIASGGGQQVIETGHLMKAILVSDENLISFLLKKLGATRQLLDGKLDELINTYPKVSGGQPYLSSQAHQALQKAEKYLKDFGDEYVAVEHIILGLLAGGDKTAQVLKDVGFEEKPLIKAIKELRGGDKVTDQNAESKYRSLERYSINLNELAKKGKIDPVIGRDEEIRRMLQILARRTKNNPILLGEPGVGKTAIVEGMAQRIVDGDVPETLKSKVIISLDMGLLVAGAKYKGEFEERLKAVIKEVTDSDGEIILFIDEIHTLIGAGGGGEGAMDAANLLKPALARGELHAIGATTLKEYQKYIEKDKALERRFQSVIVDEPSVPDAISILRGIKDKYEVHHGVRIKDDAVIAAVELSNRYISDRFLPDKAIDLMDEAASKLRIEIDSLPEELDELNRKIMQLEIEREAIRREKDKQKENELSKEIADLTGRRNELKAKWENEKAVIQGLRSEKENIERYKTEAEQAERSGDFGLVAEIRYGKIVESEKKLEAYKQQLSDMQGEKSLLKEEVDSEDIAEVIARWTGIPVSKMLQSDREKLLHLETELGKRVAGQEEAIMAVADAVRRSRAGLHDPKRPIGSFIFLGTTGVGKTELAKALADYLFNDENAMVRIDMSEYQERHAVSRLIGAPPGYVGYDEGGQLTESVRRKPYSVILLDEIEKAHPDVFNILLQVLDDGRLTDNKGRLANFKNTIIIMTTNIGSGLIQERFENLTDENAEGLIEETKKEVFELLKRSVRPEFLNRVDETIMFRPLSKADLRKIVAIQFKLIQKRLEENGIKIEADNKVLDHLGKIGFDPQFGARPLKRVLQREILNELSKDILSGKILKDAVIGVTLSENNTIEFINLDEVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N0</accession>
    <name>A0A654E4N0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ung</name>
        <name evidence="12" type="ORF">MARINOS108_10947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="24697" checksum="436F8362E095C169" modified="2020-04-22" version="1">MNVKIGPSWKSLLEGEFDKGYFKELTGFVKEEYQKHTIYPPGGQIFNAFDLCPVEDTRVVIIGQDPYHGPGQANGLCFSVREGMPMPPSLVNIFKELKGDLGNEIPSHGSLERWAQQGILLLNATLTVRAHQPGSHQNKGWEEFTDAVIRLLSEKKDGLVFILWGAYAQRKGEIIDSQKHFVIKSPHPSPFSAHRGFFGSKPFSKANNYLLKNGKESINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4N9</accession>
    <name>A0A654E4N9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">priA</name>
        <name evidence="12" type="ORF">MARINOS108_10957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="295"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="560"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="820" mass="93599" checksum="8662C0C8C537FAD8" modified="2020-04-22" version="1">MSYLEVILPLPLPGTFTYRFSDLLYPDPQIGARVVVQFGKRKIYTGIIHSVHDQTPTDYNPKEILDLVDQEPVLTLQQLRFFEWMSSYYMCTLGEVVNAALPAGLKISSESILSLNPETVLEDLDLTEKEQSIINHLLSGDIKMSEVNKILDIKSPYNHVKNLKEKKAIQVFEQVKDKYAPKKETWIRLSKSHATEDGLDQLSAQLEKKTKQLDVLLAYLRSVPLLESPSSNEHGISKKELTQSDISSSSLKTLIKNGVFEEWEKIVSRLDGMKASGAQQINLSSAQLQARKDILESFQSKGTVLLKGVTGSGKTEIFISLIQDILENGGQVLYLLPEIALTTQIIKRLAKVFGDQFGVFHSRYSDNERVEVWQKIQKGEFNFVVGVRSAIFLPFNDLSLIIIDEEHETSFKQYEPAPRYHARDAAIYLASIFHAKTLLATATPSLESYQNALEGKYGLVKLEERYNEAILPSVVLANLVKERKQRKIKGNFSSVLIEAIEKVMDKGKQVILFQNRRGYAPYLTCQNCGFIPKCPHCDVSLTFHIHQNLLICHYCGHKSEMLSSCVLCNSQELKTMSFGTEKIEEELQLLLPNARIARMDLDTTRSKYSYQKIIDDFENGHIDVLVGTQMVSKGLDFDHVELVGVFDADRMIHFPDFRSHERAYQLIHQVSGRAGRRADQGHVVIQTNDPEQAIFAHLKRQDYESFFNAEILERQQFHYPPFYRIIRITLKDNEKHLVANAAQFYAKEIRKQLGDLRVIGPVEPMIGRIRNQYLFDITVKFEKHGLNLSALKEFLLNSRNMMLSQQLYKSVKVIFDVDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4S5</accession>
    <name>A0A654E4S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphate-selective porin O/P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="387" mass="43650" checksum="D465E9E23AE67009" modified="2020-04-22" version="1">MRGVFTIVFFLVCLFYSEYVQAQIPIDASWGKGIRVEAKDSSFSLKLGLRFQTLYEGEKYLESGNWNEQLLIRRYRLKFDGYAFKPNIKYKMELGISNRDTRSGGVDEIGHTANIVLDAVVKWEFTPGVELWVGQTKLPGNRERVVSSQNMQFVDRSLVNSRFNLDRDIGLQLRAVQGSGVVFREAFAISMGEGRGVVVDNPDNGRQYTTRLEVLPMGLFKSKGDYVGADIERQPSPKLAIGVTYDYNKNTPRSRGNLGSFLMDTDNNFIYSDLSTWLVDAVFKYQGLSWNAEYAHRSSSDEVAGFGYGKGFVTALGYVFKSNYEIAGRYTTVEPIGVNSSIGAAEEYTLGFSKYIVGHSLKIQSDVSYMDTTNDYIRFRVQMELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W8</accession>
    <name>A0A654E4W8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018667">
        <property type="entry name" value="DUF2126"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09899">
        <property type="entry name" value="DUF2126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="175"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1114" mass="127745" checksum="2EBB71F8CC09B98C" modified="2020-04-22" version="1">MSIKVAVRHYTKYTYDKHIELSPQVIRLRPAPHSRTFIKGYSLNIKPEGHFINWQQDPFGNYLARIVFPEKVDHFEVDVEVIADMVVINPFDFFIEEYAEKFPFQYEEYLKRQLSPYLEVTENGPLLMELVTRAKEKKLEEMNTVDYLVALNQMVNQALSYNIRMEPGVQSCEETLQLASGSCRDFSWVLVQLLRHVGLASRFVSGYLIQLKADQKALDGPSGTEEDFTDLHAWAEVYLPGAGWVGLDSTSGLFAGEGHIPLACTPEPQSAAPISGFAEPAKTEFYFENTVKRIEETPRVTKPYSEEQWAQIMAVGDQVDADLNANNVKMTMGGEPTFVSIDNNDAPEWNSEADGEHKRKLSNQLFHQLKESYGKGALMQYGQGKWYPGEPLPRWKLACYWRLDGQPIWHNDALLADISKDYDLKHTDAAKFIEALTSELNVDKTNITPAYEDPFYFIWEESKVPVNVDLLKIDLKSPLERQKLAQLLQDGLDKPVGYAVPLSWDLEHTSWQSCKWSFRKKNLFLVPGNSPIGLRLPLDSIQYTDPEDEEIRPERDLFEETDALPLSGEAASFEPDSRPFNNSDKIFKTSLLTEIRDGKLFVFFPPVTHFEHYLDLVGAVERTAEKLQIPVLIEGYDPPADNRVQKLMITPDPGVIEVNIHPAKTWRELLSNYEILYDKARESRLTTEKFNLDGRHTGTGGGNHVTIGGSKPAESPILRRPDVLKSFITYWQHHPALSYLFSTQFIGPTSQAPRVDEGRDDILYELELAFQQVPNHKEDDVPYWLVDRIFRNLLVDITGNTHRAEFCIDKLYSPDSSTGRLGILEFRGFDMPPHYRMGMVQFLLIRALLSWFWKNPYDHKLVRWGTQLHDRFLLPHYCYKDMTEVVNDLRNAGYDFDISWFDPFFSFRFPFVGELQVDDIHIELKMAIEPWHVLGEEMSSSGTARFVDSSLERLQVKISGMTDSRYQLMCNGLRIPLKNTGVQGEYVSGIRYRAWQPPSALHPTLGVDTPLVIDLYDTWTKKSVAACKYHVAHPGGRNYNTFPVNSFEAESRRISRFFDFGHSINLVEPTVEQPTSVGRFITKVNILTNYEATGEVVNPEFPHTMDLRRYKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4X4</accession>
    <name>A0A654E4X4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4766" checksum="BDDA4EA6074C1794" modified="2020-04-22" version="1">MDGIKDVSKITGVSFWQAIITPKTNINQIEPILFMLLQSFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z0</accession>
    <name>A0A654E4Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="127" mass="14070" checksum="F6ED1624684BAC89" modified="2020-04-22" version="1">MDYLEAFSGFSVGDLNLARKFYKENLGLDVRNNSMGFLELHISGNRPVIVYPKSDHQPASFTIYNFVVADIEQTVGDLTRQGVTFEQYKGAIATDTQGISRSKHGPAIAWFKDPSGNILSIIQSHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Z4</accession>
    <name>A0A654E4Z4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_90069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="27342" checksum="479133956112796E" modified="2020-04-22" version="1">MNKEAAKHHKEAHIHGEKHFLSKFQDYLGEFVYGAIDGSVTTFAVVAGSAGAGLDSAVVIILGFANLIADGFAMSVGSYLSTKSEQQNYHKHKQIEYWEVDHMPEKEREEIREIYAAKGFEGDLLDQVVATITADKDRWVDVMMKEELEMAEETKSPLAMGFVTFISFISLGFIPLIIYVGDYIQPISADLFLISSLLTGVCFLGIGYLKSIVTNTPKLQSIMETLLLGGAAATLSYFVGNILERIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E589</accession>
    <name>A0A654E589_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18406" checksum="3D44A71C22740A1B" modified="2020-04-22" version="1">MVNALLGTFYMLKFICCAFLIFGFQLSYSQNLSVFRTEKSVDETVAKILEIIDSKEELIFFEVVSHDGIAKERGLKLPPTRSILFEDPTLTTTLINCQQTAALDLPLEIIVWEEFGDVYLGFMDPKFMKRRFMINECDETIQALGDLMIRVTMDAIRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Z2</accession>
    <name>A0A654E5Z2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="246" mass="28610" checksum="AE868F3AC8B530ED" modified="2020-04-22" version="1">MTDPISPSLLEAWNTYGQYLAYAIAGVGVLILLGHYLKLLTTTDAKSKYDYINMHEINLLWYGFLLILIGASLYANTLRANTTWLWFFVWIFVTLMVSMIVGVVIQNVLKFYYPFFIEKRLKKLRFTPRISPDGRKMKLLSEEEEDVYLDEGMQAEEDAFSVDYDVWVDEVSGYTKIEKYNGRLHALQCSECNYQTLKIDREEVVQEATTTEEGELMKYYTCGYCGHKERKSFSISKLRSEEETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E655</accession>
    <name>A0A654E655_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD13375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="83" mass="9327" checksum="CFB6DD36F67DB9F9" modified="2020-04-22" version="1">MDREAIKKDLLAIIDPYIDEKELTTEISESSDLINDLMINSAHLVDIVLDIEEKFDIMIEDDFIGKMDTVGDALDIISEKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6A0</accession>
    <name>A0A654E6A0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsmG</name>
        <name evidence="3" type="ORF">MARINOS108_90164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="210" mass="23687" checksum="4AF5952B76F7F46F" modified="2020-04-22" version="1">MSSGVQVVFDHFPDLSATQKKQFEALSGLYTEWNEKINVISRKDIDQLYTRHILHSLAIARFISFPPGSRLLDIGTGGGFPGIPLAILFPESSFFLADSIGKKIKVVQEVAQAIGLTNVHAEHIRAEQIKEKFDFIVSRAVARTRQLYNWTHQMIHSTDHPTLANGYLLLKGGELDEEMKELGRSHSVVAISDYFEDPFFETKKIVYIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6E8</accession>
    <name>A0A654E6E8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="122" mass="14305" checksum="38B57F7D0FF8A551" modified="2020-04-22" version="1">MRKFKLFFYPVYLIAIFLVLYFSMDILAHMDNYKEKIDMTFALRKLPVYLMSAFILLGVLMLVELIAENVQILDLKSRVKKAEEEVLKYKAKLYDQSQEAGDDEEESESFKIDLGDDDDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6P0</accession>
    <name>A0A654E6P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_11607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="297"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="514" mass="58289" checksum="CD0877DBD90513A9" modified="2020-04-22" version="1">MKRLAKHNLINYLQGIFDHSLHGIAMVDDTGIPFLVNARLCQIIGYSETELTSMSFGQFTHPEDVDRDLKLFEQLRKNEIDHYSIEKRYISKAGHVTPVKIHVTPVKSTKEGPWHAIALIEDISIQEKTSKKIKAANQRAKDLNNLMEETWEIAKIGSWEANLETKEVIWSKPIYKIHGVPFGEAIDMDKAFGFFHPDYRAAAQEIIAKCIETKGAWNVDLKIIARDGAEKWVKTIGQPVSHNDIMLGLRGILQDITEVKEANIKLALYNSTLEETVSERTRQLENVNKELEAFAYSVSHDLRAPLRAIDGFSNALTEDYLDILPDTAQRYLTRISDNSTRMGKLIDSLLSFSRLSRSQTSFQSFGLEERIDSIIHSIDPPIHCKITKENLGDVYGDRMLLDHVFQNLLSNAIKYSSRESAPKVHIKQISHQDSDEIIISDNGVGFDMAYYDQLFSIFQRLHTETEFEGSGVGLALCQKIILKHHGKIWAESKVGEGSTFCVSLPKKSIDNQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7A7</accession>
    <name>A0A654E7A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="12439" checksum="09F57AFADABF3706" modified="2020-04-22" version="1">MDTMPLEYKLVIIFIVAGILNLLLKRNRNWVLGYRSTRCLKSHDRFAYANRIFGWGLIILGLMYLGTLVYLAQGGDELTGWESAFIIVGYLALLFILIEYKLSKAFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7C6</accession>
    <name>A0A654E7C6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024950260" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="52" mass="5576" checksum="2B91F6CEBEB0F77D" modified="2020-04-22" version="1">MKSSSRVVKPPVLPILLALMISSCYLQATVQDACIANNGLFEIGNLLQMDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8Q9</accession>
    <name>A0A654E8Q9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Na(+)-translocating NADH-quinone reductase subunit C</fullName>
            <shortName evidence="11">Na(+)-NQR subunit C</shortName>
            <shortName evidence="11">Na(+)-translocating NQR subunit C</shortName>
            <ecNumber evidence="11">7.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NQR complex subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">NQR-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">nqrC</name>
        <name evidence="13" type="ORF">MARINOS108_110067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:47748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NqrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.1.1" evidence="11"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00427">
        <property type="entry name" value="NqrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010204">
        <property type="entry name" value="NqrC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37838">
        <property type="entry name" value="PTHR37838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01938">
        <property type="entry name" value="nqrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0288">FMN</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FMN_bind" evidence="12">
        <location>
            <begin position="118"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD15904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="235" mass="25676" checksum="E259E6D8F4DD856A" modified="2020-04-22" version="1">MGGLLSLASVGLKPAQDKQVELDTKKKILGAVMDISSIKEPNELLALYDQKVQSLVVDYNGNVVTQDAKGNPVVAEKVSIQKNYRLAAEDRLYPVFKFMNDQDPSKVEAYIFPMFGSGLWDWISGYLAVGSDLNTIRGVAFDHKQETPGLGARITSDVVQERFEGKELYNDNDELVSVKMVKGEGNPNLTAHEVDGMSGATLTGKGVNEMMVNYLTCYQGYIKKVKANGSSVAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9R4</accession>
    <name>A0A654E9R4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="338" mass="37340" checksum="D7BC977C7018EA5D" modified="2020-04-22" version="1">MKQGRVITFGEVMMRLSPPGFAKFSQATNLELAYGGGEANVAMSLAYLGMQAAHVTRFPDNIIGRSATQFLRQHWLDTSWVLYGGELMGKYFLEKGAVHRSSQVVYERDGSAFAKIQSEMIDWKAVFKDADWFHWTGITPAISEGALACCAEAIKTANEMGIMVSADIHSRKNLWNYGKTQQEVMPELVAGCDIVLASRQDIAEIFGIDVEAEKDGKFQSAAQALMDKCPRVKKIFDKKRETISASHNSIQGKVWNGKRYLKTDTLDVTHIVDRVGTGDAFAAGLIYGLLSYQDDFQALKFATAACALKHTVEGDVNMVSRENVVDLMEGNTSGKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9V2</accession>
    <name>A0A654E9V2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="29314" checksum="0575B0C24462F5BE" modified="2020-04-22" version="1">MLSVAIIEDEPLAAEDLEKTLMEVYNDARVVVKLDSVHTAVQWLDVNEVDLILSDIELGDGLSFDIFDKVRNNTPIIITTAYDQYAIRAFKENSIDYLLKPIDKTELETAIKKYRNWKQKGQEFDVDNLLEALRPYSDQKYQERFLVTLGEKINSIPSADVAYFFSEDRYTFLVTKKGTQHIINMNLGDLEGSLDPKKFYRINRKFIISYQSIQNMVAYSKSRVKIDLIPPPPNAMDVIVSVERSGPFKKWLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAE2</accession>
    <name>A0A654EAE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="26304" checksum="EE12BC9CD088BDD3" modified="2020-04-22" version="1">MSDQSKLWYFEDVDLFEILCPAKTPSMEEKHSPNVFKKDEFIYFPDQPSLNIYMIASGRIKIGSYTEEGKEIVKAILTKGEVFGELALAGEDRRSDFAQAMDDDTRVCPMTIEDLKELMKDSQELSLKIFKILGFRLRKMERRIESLVFKDARSRIVDFLKEMAEEKGQKVGFEMMIKNHLTHKDIASLTGTSRQTVTTVMNELREENVINFDRRRILIRDMARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAJ1</accession>
    <name>A0A654EAJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rpoA</name>
        <name evidence="13" type="ORF">MARINOS108_120471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="252"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD17073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="329" mass="36858" checksum="2F2CA2AA5ACBEB1D" modified="2020-04-22" version="1">MSILAFQMPEKVVMEKADDFHGLFTFKPLEKGYGVTVGNALRRILLSSLEGYAITAIKIPGVLHEFSTIEGVVEDVSEIILNLKMVRFKKISDVADTTITVSVSNTRQFTAGDIAKGTTSFEILNPDLVICNLDEKAQFEIEISVEKGRGYVAADDNKPADQNFGYIAIDSIFTPIKNVKYSVENTRVEQKTDYEQLILDIETDGSIHPENALKGAANILIKHFMLFSDQNMILESQEQGEPEQVDEELLHMRKLLKTSLNDLDLSVRAYNCLKAADVRTLGDLVNLEISDMMKFRNFGKKSLAELEQLVADKGLTFGMDLSKYKLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBI2</accession>
    <name>A0A654EBI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flotillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="485" mass="53006" checksum="5325BEAD068C2378" modified="2020-04-22" version="1">MSSTFLFIIAAVVVFVFVLLIGLFQRYKRCPSDRILVVYGKVGKGADDQGRSAKCIHGGAAFIWPIIQDYEFLDLTPISIEVMLTNALSRQNIRVDVPSRFTVGISTEEGVMNNAAERLLGQSQQSIHDLAKDIIFGQLRLVVATMDIEEINSNRDKFLANVASNVEAELKKIGLKLINVNVTDIKDESGYIEALGKEAAAKAINDARKSVAEKVRDGSIGEANAHQEQRVKVASADAMAVEGENTAKITIAQSDAARREKEAEAQKIAIAAEKVQSAKALEEAYAAEQEAENARARRDKATQTADVVIPAQIDKEKVEIAAEAEAEMIRRKARGEADAILFMKEAEAKGIYEVLTKQAEGFKQIVSAAGNNSRDAVLLIIADKLNELVKLQTEAIKNIKIDKITVWDSGNGENEKSSTANFISGLYKSVPPLQEMFGMAGMELPDYLKGKSTEEIQKLASEVKKKNEPKKPKEANDPPKDDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBK4</accession>
    <name>A0A654EBK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative solute:sodium symporter small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019886">
        <property type="entry name" value="Na_symporter_ssu_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13937">
        <property type="entry name" value="DUF4212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03647">
        <property type="entry name" value="Na_symport_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4212" evidence="2">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="85" mass="10122" checksum="5247780E24E0D8C2" modified="2020-04-22" version="1">MSENTMKQYWRRNVRYLLILLTIWFAVSFGAGILLVDQLNEIQFAGFKLGFWFAQQGSIYAFVILIFVYVRLMNKLDKEFDVDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EE80</accession>
    <name>A0A654EE80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="111"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="234" mass="25942" checksum="BFB4C136C5A68A94" modified="2020-04-22" version="1">MEKSDHTYLAIHQWAEEDRPREKLLLKGKASLSDAELIGILLGSGTKTLSAVDLAKQILSTVHNDLHALAKLSVTDLIRFKGIGEAKAITIVSALELGRRRKESEPRKTLRITSSSDAYEYMKPELTDLPHEEFWIIMLRRNNAIIGKEQISVGGVSGTAVDPKVIFKKALDVMASGLILIHNHPSGNAQPSEADKKLTRKVKSAGETLDIPVYDHLIFTDHTYFSFSDESIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSI8</accession>
    <name>A0A654DSI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="308"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="365" mass="39740" checksum="20DF8466E59E2C1E" modified="2020-04-22" version="1">MNEKLYQVALEFIPGIGDVNAKNLIAYCGSASAVFTAKISHLKKIPGIGPKTIDLLSSAQPLHEAERVIKEASKKGIDIHHFTDSSYPEKLKQTIDSPNIIYSKGTINSWSKVLAIVGTRNATDYGRTITERIIEDARDLGLVVVSGLAYGIDITAHRAALKANIPTIGVLAGGLDRIYPASHKKPAEEMLENGGLISENPPGIQAEAHFFPARNRIIAGMSDAVVVIEAARKGGALITANIADSYNRTVFAVPGDLENRFSEGCNYLIRNQKALIYTGVDDLKYHLNWDTEKPNAERPVKHDFSKLPEGDQKLLSTLSDHPAGLAVDEIAWRTQTPINQLAGNLLNLEFQGLIKSLPGKKYKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSW7</accession>
    <name>A0A654DSW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="18570" checksum="F55F0D10779584D6" modified="2020-04-22" version="1">MKDFALELGCLGFTMRLKRLSDALMHDGRKMYKELGVDIEPNWYVVFRLLKREGEMSVMEIAEKIKLAHPSVITLTNKMMKAGYLSSAQCTDDNRRRLLTLTQKAHDQLPRLEQIWNAGERGVIKALEGTDFMEMFALIEARFGEKGFKDRTIDELNKPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT25</accession>
    <name>A0A654DT25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025016624" evidence="1">
        <location>
            <begin position="22"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="269" mass="31795" checksum="1A6139BFF6D565C8" modified="2020-04-22" version="1">MMKFRLCLITIGLFFSVSSMAQRFGQSQDVIEVGESMEEYIKENHVDDIEDIVHKFTESRVFLKYLLEQGHHINSDSVKLRRKDISIGHDIDVFVKHFSDHQNFTMLMVPVDIYPLMIYDTLLFSVLEVSDTWLKEKYYYHDISDDSVKASLLATENHDLLTKHMYEQVMAERKQSSAEVEVKLHESYISTNSILLNTHELDKEEREKIMKSWGLFKRLLTHNLELSVEMNIYIFGHDDMSIIHYTDRGSTEYRITPSNVFTRHHFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT76</accession>
    <name>A0A654DT76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024852243" evidence="2">
        <location>
            <begin position="19"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="617"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="894" mass="100135" checksum="EAE611463825DED2" modified="2020-04-22" version="1">MMKRILTVTFLLTTLLTAAQQDLFLSGENYFQQGQYIRAFESYQAASVGFQQQQTLDQYALCNLKMAECHLETGALNQCMSQARNTLEYITDVLPQEKVLQLRAQLLLGEAYLKAGRNDLAMETLTGAEQSLPDPTDLSAAECYNDLGVVYWNNKNKETAKSYHERALKIRKARLKGEDPLLADSYLNLGLIYLEDDFLQAVINFNNALKIYQAAYGKNHPSVALCYGNLAFANSAQNNFGEALTYLDLTMNIWDSHYSGDHPNKAFTLSNRGRILEAQGDYHKALLTQQEALQQYIRLYGDKHPEVANTFYLIGSVQLKQENYKEAVESFQKSIYANLQNQEYTSLYDLPELQDYFNADILLSSLQYKAQALEALHFGKTLKPSDIKSALSTYLKCDDLISQIRQKRLTEGDKIRIGSIAADVYDDGIRTALYLSDKTFQKKYFREIAFTFCERSKSAVLLEAINETKAKAFAGIPNHLLALEDSLKTEISLLEQLLANTMDESRLGSLQNALFETRQSYRTFITSLEKEYPNYFNLKYRQADISVAALQEKLTPTAGVLSYFIGEESIFIFLISKKDFEVFSLPKADNLVQLTKGLRNAIKYHIPSTFQSSSVSLFKQLIPDLPDGLQSLTIIPDGLLGTIPFESLLSESKDGGNNTYLLEKYAISYDYAASLLLEKLDAPAGTARGILLTAPVSFEQNELTMASLPGSEQEVKEIRYLFLSEADVPEILLNEEASEAMLKSSKLSGYKYLHFATHGIVNESKPALSRIFLSPTENEDGSLYSGEIYGLNIGADLVTLSACETGLGKVEKGEGIIGLSRSLMYAGAKNLIVSLWQVSDASTAQLMIEFYKQHLNHSGNMIFADDLRKAKLSLLKSASYSDPYYWAPFILIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTN8</accession>
    <name>A0A654DTN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="376" mass="41445" checksum="01EC76725E084B40" modified="2020-04-22" version="1">MTIIGGGIAGLCTALALQNRGIRAEVFEASPKLEPVGAGLGLGANAMLAFKELGIYDDVVQIGRSLPSFALYDHLGKRISHTQFDPNDTIGSFTIHRANLHELLLSRLDPAQIHLGKRVVKYQAEDFSVSLTFDDGSTHITNYLIVADGIHSVVRQTLLPASVPRYSGYTCWRAVIDNSTLKISQSSETWGPKGRIGLVPLPDNLLYWFICINAKKGDLKHYGVKELSSQFDQYHAPIPQVLAATEDHQLIHNDIIDLKPLSQFAFGRTVLIGDAAHATTPNMGQGACQAIEDAVVLGQCVEKITDTEEAFRLFEKRRLRRTRWIVDTSWRLGKAAQLENGLLIGLRNAALRSLPPSVNNRQLDKIKTVDFLSNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTR6</accession>
    <name>A0A654DTR6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="21647" checksum="2B3E662AC36126DC" modified="2020-04-22" version="1">MTQPDIAQPTTGMRNILLDLAVTLDGFIEGPEGEIDWCIMDDDMDFEGFLAGVDTIFYGRVSYDAWGNFQPDTQASPAEQRLWRAVHSMQKVVFTSQLRQDDRATFISSDLVGKVAEIKKQDGKDIWLYGGAGLITSFIRHGLIDRYRLSVHPVVLGRGKPLFKHLKERLGLKLIETRTFQSGVVQLIYEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTZ7</accession>
    <name>A0A654DTZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="42149" checksum="2A2AEDF90152D8EB" modified="2020-04-22" version="1">MNNPLWLMTSAFDHLQLPQIIEKAQQVGVQGLDLCVFRRDGTRADHVATHLDYEDFRPEEARKIIAQFNAANLKLSIGAFENLIGGDEAERVKNQNHLLKLIRIAHLLGGDANDVKVGTFVGYNHELGVQEGGFQRNLEEYQRVFAPIVQYAADMGVTILYENCPMEGWRSAGYTSTYNNLPGVLAARKLMYELIPSCSHGEIYDPSHDVWQGIDPTEVIKAMDISRLHRVHVKATRNLHNDTRNHWGAMYPMQSVDQALARKAGVPIPAHDWDRHNYEAMMPGFGGSDSMDWRAFVAELMARGFDGPFEMENEAALSKATSNDGAIMQGYKASLLFLAPMLWPLTDTGYQYNSAGVAPLKEPSTQNVPIVTMKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU00</accession>
    <name>A0A654DU00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="473" mass="51659" checksum="C3799CE1CD3F75C1" modified="2020-04-22" version="1">MIALMTLIGWTANAQNWQLVWADEFTNGIGPDWVFETGTGSGGWGNNELQYYRQQNATVQNGELVITAKNESFGGMNYTSARMKTQGKKSWKYGKIEARMQLPAFQGSWPAFWMLGDNITSVGWPSCGEIDIMEQTNTSDHVLGTIHWNNNGYVYYGGNTAASVTGYHVYSIEWDANAIKWFVDGNLYHTANIQNGINGTSEFHEKFFIILNLAVGGNLPGNNVNNGALPASVKVDYVRVYQSTGGGTGAPVGQTIWLRGSNGQYASSENGAVPMNCNRNSVQGWEQFTVVSAGGSKIALRGSNGKYVSSMNGQSGMMCDRTTVQGWEAFDWVSNANGTISLRGNNGLYVSSENGQSPMICDRTTIQGWEQFTWGTGAGARQAPELDSELSEPVALTVFPNPVTNHEFKVRWDHQVSPEVQLSLMDVSGKTVYTAVAKDGLENVVLPSHLRKGVYILGITSEKGTETRNLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU61</accession>
    <name>A0A654DU61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="41"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="424"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="635" mass="68556" checksum="A146B7E2B9B9782D" modified="2020-04-22" version="1">MKTNSILWGHQPPSIQSIIWKHIRLLLFLFVIMSMATVHAQKIVGYTPSWLGSANDIDYDRLTHINYAFALPTASGGLQAIENPAKLQSLVSQGHAKGVKVLIAIGGWDLGDGGGNDGRFNTLAASASSRNNFVNNVLSVINQYNLDGADIDWEFPEPVNGAPDNNFTLLMGQLSTALHNQGKLLTAAVNGSAWAADGISSQVFGYVDFLNIMAYDGDAGAGHSPYSYAESALNYYKGRGLPAAKAVIGVPFYARPSWKGYNTLIAEGADPYSDYFNGDYYNGINTIKAKTALAKSQGGGIMIWTLDHDVQGQYALLKAIKDEMGTTGGSGVVTLFQHCDYGGYSASLNTGSYTLGQLQALGVANDDISSLQVQNGYQITMYQHDNFTGNVLVKTSNDNCLVNEEFNDDISSVIVAQASSGWSATIEAENWTIQSGTQTEACAEGGQNVGWIDTNDWMVWDINPPSSGAYTVEYRVASPNSGMIQLEKAGGSPVYGTRSVPNTGGWQNWTTISHSINLTAGQQQIAIKALTGGWNINWLKLTSSSGSRIALESQKSHINHPDLRIFPNPTSDYLEVQGSAGTGSYTIYDLNGKAVSNGHHSPQEDHKKIDVRQLKAGIYFISHSKSKKVLRFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU82</accession>
    <name>A0A654DU82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022172">
        <property type="entry name" value="DUF3703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12487">
        <property type="entry name" value="DUF3703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14101" checksum="1F06EBE7DDDAFE95" modified="2020-04-22" version="1">MIFNTSMPTPLRPYFAAELEAYRQQHQMNNLQSAWRHLERAHVIGQAYPYAHSLVHWKMLLFGIQIKSTKEVIGQIPRLLIGGVKSFVGKIPVGNTGGSNIPPLRSLPIEPEIQDIFAQCGLPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUA3</accession>
    <name>A0A654DUA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">trmB</name>
        <name evidence="2" type="ORF">MARINOS108_10662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="220" mass="25898" checksum="49344395A624F934" modified="2020-04-22" version="1">MRKKLVRFAENALRDNIIEPGKPLFDEIKGNWHQLYFKNDCPITVELGCGDGEYTVGLAGVQPERNFIGVDIKGDRLHQGSTIAIEKGLNQVGFLRSQIHMLDKFFGEGEVDEFWLTFPDPRPKKGDAKRRLTNPRFLQMYQQICKPNGWFKFKTDSTSLFEYTLEVLEQEFKVENLEYTRDLYKSDLMADHHGIKTKYERIWTERGEDIKYLKFRFKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUC5</accession>
    <name>A0A654DUC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="161" mass="17914" checksum="124CAF1FD7E9DD27" modified="2020-04-22" version="1">MMNIKYLPFICLIAIMGSCIDQSESRDIEMKPSRAKIFSKGVRLESDHFHGNAWLDVLVVADSVNQNAVGSVTFEPGSRTNWHSHPNGQIILTLEGEGYYQEQGSSKKILRKGDVVKCPANLPHWHGASPDSEFVQVAITSRVNGPTEWLSPVSDEEYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUG0</accession>
    <name>A0A654DUG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="87" mass="9569" checksum="13C88035B3991EA8" modified="2020-04-22" version="1">MVTPTFCITISELRLEGTFTGSPDGVMKEAVSIKKINNRKIISVIDDILKAASTLCFELRFISAVPEVGQQNQWPNIPSYEQVSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUG8</accession>
    <name>A0A654DUG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="71" mass="8183" checksum="933B05047B140DD0" modified="2020-04-22" version="1">MKVTALIEDDLIDKIKEATGGRNITDSITIALKEYLRNKNIDKVIDEVEKEPFVFNEDMAAYGIRNLNRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUH6</accession>
    <name>A0A654DUH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylanthranilate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="206" mass="23267" checksum="ED910D4F6877C991" modified="2020-04-22" version="1">MSLKTFVKIGKIENLSDARYCAGMMVDILGFNLEEGTEGYLSPERFKEITDWVAGVSFCGEFAHAQVAEIKLAATQYPVEYIETQNIDQLEELAELSQELIFKLVLTDAKDLSKLESSINYASEFAKFISIHLTDDSQKNEAEAILSQMNSRPKLLRGYELTHENAFEVVDDPIYFGIELEGSPEDRPGFKDYGNVMDILEVLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUI6</accession>
    <name>A0A654DUI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SASA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="300" mass="34005" checksum="26AC75E417951143" modified="2020-04-22" version="1">MLKLVLSLIFLIPLLSTGQETIKVFYLGGQSNMDGHGYNTDLPNDLRSFDDVYIFHGNRANDGEAGGDGVWEVLKPGHGTGHQSTADSNQLSERFGVELSFAAKMQELYPGEKIALIKYSKGGTAIDTLGNPRRGNWDPHFRSKINQYDHFLSTLRNAFANTDIDLDGVDEVLVPSGIIWMQGESDAPTAEIAGRYYNHLRELMTLLRAALRDDNLPIVIGKISDSWHERYHGKVWKYGELVQYGQEEFVRTDKNAAIVRQTRYYQYSDPWHYTSADYIDLGVRFARELNNLLQQPEPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUZ0</accession>
    <name>A0A654DUZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="17097" checksum="8503E97919EB3545" modified="2020-04-22" version="1">MFEKMSNQDFTLTLLVDRSPSEVFRVIKNVPGWWSGMHGEEFEGKWDNVNDEFSFTAAGGAHYNRQKLVELVPGKKIIWLVTESELSYIVDTDEWVGTQICFELFEEDNGTKIVFTHKGLTPEVECYGSCSVSWTDYLQQRLLKALSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV39</accession>
    <name>A0A654DV39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027848">
        <property type="entry name" value="DUF4494"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14902">
        <property type="entry name" value="DUF4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18733" checksum="D94EEB864FDB4E7E" modified="2020-04-22" version="1">MKIWYSCKVKHNKELDDGMLKQVTDAYLMDAVSYTDAESRMYEICERDISGEFTVTQITKTNIAEVIHHEDSEKWFKSKVVYATVDGDSDKEVKINTYLLVSADHVKQAYERIEDHLNSMLVPYDIPSITLTNILEVYPYDPDEEKIPSNLKPLSEVESDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV47</accession>
    <name>A0A654DV47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043741">
        <property type="entry name" value="DUF5686"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18939">
        <property type="entry name" value="DUF5686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024987899" evidence="1">
        <location>
            <begin position="32"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="839" mass="97167" checksum="40BE191A63DC84EF" modified="2020-04-22" version="1">MICVGFSSSSRLSLKKFLFTVFSLFSLVAFAQTTTVSGKVIESATGTPIPFANVIFTGTQDGTITDFEGNFIAKTIQKVDSIEVRYIGFIMRAKPLERGRDQIINFQMDEDVKTLGEVVVYAGENPAWPIMRNIIRNKGLNDKRSLSAYQYESYTKVEFDVDNISDRFRNRKIVKKITNVLDSIEQIAGEDGMPILPVFISEAISDFYYKRDPKFKHENIIKTKVSGVGITDGTLTSQVIGSTFQEYNFYQNWLNIVTKEFVSPITDGWRLYYEVYLEDSAYINDQFCYRIDFYPKREQDLAFTGTMWITKEEYALKRIDASVPKAANLNYIEKIKIQQDLIKTSAGPWLPEKTRVVVDVSQVTKETAGMLAKFYVSTKDHIVNQPKPNSFYLNPVVMEETVRDYDEQYWAENRHDSLSPTEINVFSMIDSMKRIPVVKTYMDLAKFAVNGYYKVGAMDVGPYSTFFGNNNIEGVRVGFGGRTTIDLSRKWTFGGHLGYGFDDERIKYRFYADRILDRQPWTNIKYEQQREVEQVWLLNEQIEPNSLFYSLSRFGTLTQPFLINKYRLSLFRQLSAGFGATFAMKHESFDPFFDFQYYRSPGDTETSSMYKVSEASVSMRYAKDELFVINDNERLSLGTVRWPAFNLDYTYGFKGVLGSDFNYHKMKLSAEKDQKMGILGVSKIKLTGGYIVGDLPYTLLYNTIGNETFFYVDFAYNLMDYFEFSTDKYIEFRYRHSFEGFILNTIPLMKKLKWRLIGSANMLYGDISDRNLAMTRNKMVDGVEVLPFHQLDNRPYVELGYGVENIFKIFSVEAFHRLTYLDRQDVRKFGLKFNIQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA7</accession>
    <name>A0A654DVA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="15844" checksum="A6D2761668372C36" modified="2020-04-22" version="1">MATTNTYLNFNGTCEEAFNFYKSVFGGEFNYIGRFGEMPESDDYSVPEGDKNKIMHVSLPIGTSILMGSDIGGDWAPTFIQGNNFSVSITPESKQEADTLFNALSKGGQVTTPIHHSFWGAYFGMFTDKFGINWMVNFEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVB4</accession>
    <name>A0A654DVB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024841721" evidence="2">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="34161" checksum="3A7621DF0CFAE07C" modified="2020-04-22" version="1">MKYGSILLVTILCMLSVQSIAQDNQTINGILTVNTSGTSNTIRVENDIAGEEATIRFRSKPSNGSGWLHSDISSFATGYNTGFLGFKVPHNNTFGSGFDMIINHSGNVGIGTITPSDKLHLVGSNPTLRLSSSTYYGGTGNDLNAVISTIKFSNRDDNHNYRAEIRGLLTGGWATSVGLAFTTHSGGEQVERMRINHDGTVGIGTANTFGYQLAVNGTIGSTEVKVENTSAWPDFVFDNGYDLLTLEEVEQYIYDKGHLPEIPSEAEVTENGINLGEMNAKLLQKIEELTLYLIEQNKEIKELKEKVNRLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVU2</accession>
    <name>A0A654DVU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="39169" checksum="6C9B41831A170F62" modified="2020-04-22" version="1">MRILKISRGAPNDQLRALLNENIIGTPGESLVYQQRMVNPKLDHISNPVFLTVELGDRVVGACCLVGRTVSNSGQDSPAHYIRYLTFQSRFRAPSNALQRLEKKSILKDEIAEVLSGKGLEIPEGHLFYAYVDPDNLRSKRLITSFGFEEVGRFRTVFFSRLFPKRHPKIAPVKENELEDIKRQLQTTYGDHCLFTTENIGFQDGYLGYYENGELVAGLQANQEAWRVYEIPGGKLLLDLVSRIPLINRLFSKNFRFLSIEGVFCPEGREGLIEVLLEDALARSERSTAIICLDPESDLYRKFKQLDQGLIRRLTTEKEMAVMAKGADVGHLKQHPVYISGFDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVZ0</accession>
    <name>A0A654DVZ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MARINOS108_10819</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="569"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VXD12048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="768" mass="89495" checksum="213E87FB3B98A7DD" modified="2020-04-22" version="1">MAKKRIHVEVGKYKLELSNLDKVLYPEGEILKAQVIEYYLTLAPTILRHIKGRPLSLVRYPDGIYGEQFFQKNRPDWTPDWIDYIRLGKERKKEYIVAREEATLVWLANLACLEIHQIHSFSEYADKPDYIVYDLDPPEGKDDFEEVKSLAFSLKEELEQLDYHVFVKTTGGKGLHLITPLEVNYSFDECFDTAKKIAEAFIRKHKNTTLHLNKEARKGRVLIDIFRNKSSQTIVSPYSLRGRAGAPVSAPITWEQLQDIQGAQELTIALVKDMVLNDGDPWEDIRSWAVPLHTDTQRRSVYKNLPQNPKHKSPEQLAEYEQKRDFGKTPEPYVPEDDGRGNRFVIQRHHASHLHYDLRLEQDGVLKSWAVPRGMPPVPGVKRLAVQTEDHPLEYLSFEAEIPKGQYGGGMMWIYAAGRYEITKEKKNGFYFRLSGPQINAEYRMHLMKNKEWLLERVDKPQQNFLEMEVQPMVAEALKKPPKGNYRYEVKWDGIRVMITLNEGKMIIRSRNMNDITAQFPELNIPEEAFRVNNGVFDGEIVCLDPQGRADFRKVIKRLMTKKQMEIDYQVRKSPAYCYLFDVPYLDGRSLVNDPWIRRREWLKDSFRKNTPYRFSEDIEDGQALFEAAKTMGIEGIMAKDPLGKYYPGKRSTAWYKVKVKNTVDAFVIGYTKGEGDRERYFGSLHLVELEGDQLAYRGRVGTGFTDKLLAELKDYFDSLEVIEKPISEKVSEESVWFRPVPCEIEYTSLTKDRHYRDAVFKRLREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW04</accession>
    <name>A0A654DW04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fadE</name>
        <name evidence="9" type="ORF">MARINOS108_10537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="255"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="602" mass="66112" checksum="0E0B2CE88460D3D0" modified="2020-04-22" version="1">MEAVAQKSAIKGGEFIIRETSADEIFIPEHFTEEQKMMAAATQDFIDLEITPNVDRIDSMEPGLMPALMEKAGELGLLGVAVPEEYGGLGMNFNTSMLMADIIAASGSFSTAYGAHTGIGTLPILYYGTEEQKQKYLPKLASGEWKACYCLTEPDAGSDANSGKTKAKLSDDGKHYIINGQKMWISNAGFADLFIVFAKIDDDKNLTAFIVEKEFGGITMNDEERKLGIKGSSTRQVFFNDCTVPVENMLSERENGFKIAVNVLNVGRIKLGAGVINGCKTVASQATNYANERKQFGVSISSFGAVKAKLATMATKTYAIESAAYRAGQNIDDRIESLINEGMDPSKAKLKALEQFSIECAIIKIHGSEVLDFCVDEGVQIYGGMGFSEEAPMARAYRDARITRIYEGTNEINRMLLVGMMFKRAMKGELDLLGPAMAVGKELTSVPSFETPDMSAPLAEEKDVLKKLKKAALMVAGKAAETFGPTLNDEQEVLMHIADMLIEIYAAESTLLRTEKLMGIYGDEGSQLYQQMAKLYMHDAVQKIRNHGEEAVACFTEGDELKVLLMGMKRFTKINSVNTRDLRRAIADKMISENKFPYSLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE5</accession>
    <name>A0A654DWE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="216" mass="24460" checksum="68624590D6AB38F4" modified="2020-04-22" version="1">MIGLIFDMDGVIVHNNEYHYLAWQKLAKKYNVKITRKYYREKMNGRTLMELMEIIFDGELDKSQALSVGLEKEAIYRELYAEHREATKGLIPFLELAKSKNIPMVVGTSAPKENVVFTLDGLDLRKYFVGVVDDSMVTKGKPEPEVYLKCAEMIKREPQKCIVFEDALSGIKAGQRAGAKVIALATSHGREELSADLIIDDFSQLKWEQVEALLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWE6</accession>
    <name>A0A654DWE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="103" mass="11824" checksum="543EB8C6323949DB" modified="2020-04-22" version="1">MSFEPMHQNVEKSQFELNHKGHTALLLYKQNKGSKRIYLVHTEVPEAIQNEGVGQQLVKEALDFVVQNELKVVPLCPLVIAYLKRHPAYHGVIDESSKKDFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWH7</accession>
    <name>A0A654DWH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024842875" evidence="1">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="316" mass="35214" checksum="220C9BEEBA38BAEF" modified="2020-04-22" version="1">MCQFRRILAICFTVILPFLTHGQNSTNVSEMIATYKYPVQYLSINSETEVAYIDEGQGDQTLVFIHGLATYIPSWYPMVDHFRSQYRCIAIDLPGYGRSSKGDYPATMSYYAGVVGQLIDSLGLKNVVLVGHSMGAQVAVTTVLNLPNQFEKLILLAPAGFETFSPEHASLLKATAVTETFLNATEAQIRASWAMNFYQMPESVEFMIQDRINMMEASDFERYCQSVARGVHGMLDQPIADRLGEIRQKTLVVYGEEDALIPNRYLNPGLTTKKVAESGASKIQEAVLKYVPACGHFISFDKPAEINEIVDSFLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWL1</accession>
    <name>A0A654DWL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14040" checksum="1B2846700F847E0E" modified="2020-04-22" version="1">MKFSIDRQDQYTILKIDEEKLDSTIAPEVKSEFVTLQAEGVKNIVLNMEVVKYSDSSGLSALLVGNRLFKDTGSFVMCKLNEHVMKLISISQLDKVIDILPTVEEAIDAVMFNDIERGLREAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWV1</accession>
    <name>A0A654DWV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="301" mass="34394" checksum="D47B03C5571A94F1" modified="2020-04-22" version="1">MKFAAIDIGSNAIRLQVTKVIEYEQLITFKKLQYVRFPLRLGHDVFTNKMISPVNQEKFVKLMTAYKNLIDLYGVDHYFGCATSAIRESANGKALTERVLNEVGLKINIISGVKEAEMINEVISLDLDDKTYLHVDVGGGSTELNFYYKQKKVASKSFKIGSVRRLEHHDSPRAWKEIERWVKDELKDHKEKVTAIGTGGNINKIYELSPVSKKRKISLESIMKVQDYLGNLTLDERLNRLQLNPDRADVIIPASEIYVHAMKAARARSMLVPDIGLKDGINYYLFEKYYPSRGKIFVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX72</accession>
    <name>A0A654DX72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025068321" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15124" checksum="AB5B1434467DDED3" modified="2020-04-22" version="1">MNRLLNYIIIAAMALVAVACADPEDPSPTKMAYGDWYVLEVYVNDQVNPSDVIQRFTLERDGSYILVDENEFATVGTWVATDAALTLSGADGSVMDFTIEFQSYQKMRLLQTIESPSAGTIEIRYLMNKDSDGSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX93</accession>
    <name>A0A654DX93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="39182" checksum="B400BD54781BBE33" modified="2020-04-22" version="1">MNPYLSIVAASRNDNHGGDLTNRMEVFLRGLYHQLSQYHLPTEIIIVEWNPPSDRPGLSAILPKPPSNGNIILRIITVPYEIHAQYKTSSHLPLFQMIAKNVGIRRAKAPFILCTNVDLLFSSKLVHFLASKKLKKGTYYRCNRCDIPKEIDYSAEIPVLLKFARKNIIQRLGKNRLYPNFNGQSKWWYHNILTLGMVWGIALIKRFTESRLTTTIESADTWACGDFTLMHREDWEKINGYFELDAYSIHIDSLALFAALGQGIHQKILAPELCIFHISHRAGWELQDPMQKIKFDIQMPMLDWNTAKAACEHMLREQVVLPINGPDWGLLGRTLNDTTITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX97</accession>
    <name>A0A654DX97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="253" mass="27144" checksum="FDA2F4663CFF377E" modified="2020-04-22" version="1">MTKRKIALITGGSRGLGRDMAIKIARRGLDVVITYHSNQAAAEAVVAEIEKAGSSGYALQLDSSNTKGFDVFYKQLSDYLIHKTGSAHFDYLVNNAGTGIYQPFSETTEEQFDEMMNIHLKGVYFLTQKALPLLNNGGSIINISSGLARFTFPNSSAYASMKGAIEVFTRYLAKELGHRGITANVVAPGAVATDFGNGTNKTNEQKRKIVSSVTALGRVGEPEDIGGVVAFLCSEDAHWVNAQRIEASGGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD6</accession>
    <name>A0A654DXD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="14862" checksum="C55377E3046AEFDE" modified="2020-04-22" version="1">MRPIIQIEDIKLLVDCFYGKVQEDELLAPIFNGRIADKWPEHMEKMYRFWQTVLLGEHTYLGSPFAPHAHLPVDHTHFERWLQLFYETIDGLFEGEKAEEAKWRAGKMAEMFQLKIAYRQQHGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT3</accession>
    <name>A0A654DXT3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truB</name>
        <name evidence="7" type="ORF">MARINOS108_11174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="31"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="227" mass="25011" checksum="A979F9C5A4DD1A0A" modified="2020-04-22" version="1">MDLNAYTEGQILLIDKPLTWTSFDVVKKLRYALKVKKIGHAGTLDPLASGLLLIGTGKFTKKLNELQGLDKTYEGIITIGKTTPSYDLETDFDSETDISHLTKEDLQAAALKLTGPIAQVPPAHSAVKVNGERAYKKARKNIEVKLDPRSITIHEFQLLKVEGADVHFHISCSKGTYIRSIARDFGEILGVGGHLSSLRRTSIGEYQVSDAEDLEAFVAKVRDDETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY43</accession>
    <name>A0A654DY43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14948">
        <property type="entry name" value="BACON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14251">
        <property type="entry name" value="PL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039513">
        <property type="entry name" value="PL-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14592">
        <property type="entry name" value="Chondroitinas_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024865144" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="675"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="901"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1142" mass="118937" checksum="606141B910AA21D6" modified="2020-04-22" version="1">MKIFFRKSSFLLMLVGATMFSSLAAFGAEYTVSSAGQLNSLSLSAGDIVTWTDGTYSNQDITFTGSGTQSNPIILKAETPGGVILNGSSKLNIYGSYLIVEGFFWDGGEGESDHVEFRKSGSSTEFANNCTIRNCGFDNLYTPEPNKSRWIVLHGTNNVVENCSFVNKLSAGACILVELSYAGSSTPGHSIRSNYFYNITPKDNFSTNSGDCEAIRIGVSSYQSVSAQVLVEGNYFKAADGENEIITNKSSDNTFLHNTFRNCRGSLVLRHGARAHIEGNFFLGEGKAKSGGIRVSDRDHVIINNYMQGLNNDGDVWNNGITLVGGGESSGGSGNGYQNVDNILVAFNTIYNSDDPIHYNDRNSYDPTGVIAYNLVYSTNGDIVSGDISGTGQGMTYVGNIFGGSNIGISDPGITEGDANFSAVGEIYKPSSSGIAANAAGSTYANVVDLDIEGLTRPNSNMDVGAHEVSGASGSIAYAPITDGDVGAGVGACFLDAAGSVLSACGAVGDYLTVSSVSEFTDAGGTQSAAISSNVSWTVTDNQSWISVSPTSGSGSGNIDITVNANANTTERSGTVTVSGVGVPDRTISITQARYVAPVNVTGVSLSPGSATVGVGGSQQLSATVSPNDATNQEVTYSSSNTSVATVSGSGLVTAVAEGSATITVTTDDGGYTDTSIITVSAPSSETNLALNKSISGTGTPDGTNVPANLVDGDVATRWSVSGFPQSATVDLGAVFTIGRTELTCYSDRAYQFIVEGSSDGSTYTQIVDRSGNTTPGADSSPIIDTFSDFDARYVRITVTGADVYTGSWVSLTELRVFAGEGGPEPVAVTGVSLTPSSVTLDEGDTQQLTASVSPSNATNQGVTYSSSNSLVATVNSSGLVTAVAEGTATITVTTDDGGHTDMSTVNVVDPTPTLSNVALNKSVTTSNEQSTNPGSNLVDDDPDSRWSASGFPQSATIDLGANYTISSTEVICYGDRAYQYIIEASVDGSSYSTIVDRSSNTTGGSNASPISDTFTSINARYVKITVSGADVYSGSWVSLEELRVFGYAAGARVLSSPELNDSEVGVSAYPVPMSDVLTLEFEDFSEFVSLDLMDMFGRIQLRNRDINSKKMTLDVYGLSDGVYLLRLYKADATTRVIRIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY75</accession>
    <name>A0A654DY75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="240" mass="27442" checksum="CE9590F361238D20" modified="2020-04-22" version="1">MSNIRILSVEDDPIYAETIRFTVEQAGYQVIDVIADSTEALRVIESTRPDLLLLDIHISGPHNGIELANKLNPAIPIIFITSLRERSIFEQAKQTKPFAFILKPFDPLMLTNAIELAVANLAGEKKDVWKEKDVILSDSFFIKEKNVLVKVMVKDILYIKAEDKYCILHTPQKKYIIRISLKDLLAKIPSNYLQVHRSYVVDSLRISQIILEDFMLYIEGEPVPIGMSYKDQVLSQIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP1</accession>
    <name>A0A654DYP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16123" checksum="4B5844AF34EFD7A3" modified="2020-04-22" version="1">MRKYMDASPEAGKEFYQHFHNKGKVVMLNLLKFRATADYTNLEALKPAEEISGEEAYQLYMKSTLPELEKAGSRVIYYGKSKSFLIGPDTEKWDAVLLVEHESVSRFMEFAQNGDYLKNAGHRTAALEDSRLLPTNEMSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYS9</accession>
    <name>A0A654DYS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="74" mass="8766" checksum="D6AF50B3C6C6D563" modified="2020-04-22" version="1">MSIFPKKDFPDLLCWDNQIIEVSNSEFIRTHNSIVVLRANRQIYNYIDDFALAKNILKMNPNLSNPERPRLDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYV2</accession>
    <name>A0A654DYV2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltA</name>
        <name evidence="9" type="ORF">MARINOS108_10751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="429" mass="47875" checksum="1DB0B9790956F6F1" modified="2020-04-22" version="1">MSNTAEIKVDGKSYELPLIEGTEKEKAIDISQLRGQSGVITIDPGFKNTGSTKSAITFLDGEKGILRYRGYPIEQLAEKSTFLEVAYLLIYGNLPEASQFEAFKSQITNHTLVHEDIKKLLDGFPSTAHPMGVLSSLVTSLTAFYPQSLDPNRSGDDVNLSIIRIIAKMPTFAAWSYKNQMGHPVVYPDNRLDYCANFMKMMFGLPTEEYSVDPVVVKALDKLLILHADHEQNCSASTVRIVGSSQASLYASLSAGINALWGPLHGGANTAVIEMLEAIKADGGDTKKWMAKAKDKDDPFRLMGFGHRVYKNFDPRAKIIKKAADDVLEKLGVNDPVLDIAKGLEREALEDQYFVDRKLYPNVDFYSGIIYRALGIPAEMFTVMFALGRLPGWIAQWKEMRENKEPIGRPRQVYVGENERDYMPVTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW2</accession>
    <name>A0A654DYW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="5680" checksum="46D7348D4E8844C6" modified="2020-04-22" version="1">MVEVADAVLPDQRRISEEDQAEEDKSLWRKGVPGKKSGTLFYALTLSKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYX2</accession>
    <name>A0A654DYX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of Hsp90 ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039981">
        <property type="entry name" value="AHSA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="PTHR13009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="126" mass="14744" checksum="96A0FEED4C0833C2" modified="2020-04-22" version="1">MADFKKYFIVAGQPEEVYAALTFKPTIELWTGSPAIFKPEVDSEFSLWNGSILGKNLEFEEGKMIRQQWYFGEQDTPSIVTLKFHLHKKGTSIEVNHTNIPDQDYDDIVDGWHEVYMKELTEFYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY0</accession>
    <name>A0A654DYY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnII</name>
        <name evidence="5" type="ORF">MARINOS108_12155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="85"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD14837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="37438" checksum="6E1DDA6AC6BD55D3" modified="2020-04-22" version="1">MAKSKLEYIWLDGYKPTQSLRSKTKVVSNFSGKLEDLDDWSFDGSSTEQAEGGSSDCILRPVFVCPDPVHENGYLVMTEVMNADGTAHESNGRATIDDEDDDFWFGFEQEYFIWDPATDKPLGFPANGYPAPQGPYYCGVGGQNVFGREIKDEHLDLCIAAGLNVEGTNGEVAAGQWEFQIFAKGAKQAGDEIWIGRFLLERLVEKYGLFIEYHPKPLGQTDWNGSGMHANFSNSFLRTAASKEKVEKVCEAFRPLVKEHIAVYGAYNDQRLTGKHETASINDFSYGVSDRGASIRIPLYTKTHGWSGYLEDRRPASNADPYKVAARIIKTVKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYZ6</accession>
    <name>A0A654DYZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="131" mass="14884" checksum="D623D2D886365500" modified="2020-04-22" version="1">MIRTHLNLLVQLAKVDGVVVQDEIDLIAQIGEANGMSSSDISACFEDSSLIENLENLTDDEKYEYIYNIVQLMKIDGRLYKEEIRFCAKLASKLGYNEDVLLELMLKIYSDPEISADKASLKSTIQQYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ30</accession>
    <name>A0A654DZ30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024935787" evidence="1">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="427" mass="46516" checksum="F41D8F9292E4A05E" modified="2020-04-22" version="1">MKTRLTLFIALVLINTLLQAQPWDYEGQSVIYSLVDKVGVGLKTPSGKFHILHSGTLGGKADASKSYLTLSDGTNQMFFDVNEITGTDQMIIGAQGGIRFRYVNSSGFTERMSILPSGEVGIGTIAPAGKFHVQSQNIGSQHYLTLANIFEATEARVQIIALDKDNAASMIHLTNVPEGGGNNKHWGIHHTGALRNDRLEFGFGTTTTSGDGNAWDLPAKMVIETDGDVGIGTATPGSRLDIRGGDLMVYKNDIRLLDVNNGASDGMGIGHMSMSQMSIFADAEIHFKESDEMATKVWIDLNDGQMGIRTTSVPADYAFAVDGKAIMEEVKVEMSGSWPDYVFDPDYTLPTLEETSAYVKANQHLPGMPSAKEVAANGISLGEMNAKLLEKIEELTLHTIRQQEMIDALNRQNQYILKELAHIKDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZG4</accession>
    <name>A0A654DZG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="11814" checksum="B71E0542FCF8B03D" modified="2020-04-22" version="1">MITRIVRMSFTPEKKDDFLEIFHGAKKKIRAMEGCQYLSLHRDYHHVNVYYTLSKWDSQEALDQYRDSDLFKTTWKATRKCFNEKAQAYSLKQEVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZN1</accession>
    <name>A0A654DZN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6107" checksum="A4ED92FECF199F73" modified="2020-04-22" version="1">MGPFFSAIAKRSFEEFFKIREMIKLGSRYEEKMVVVFGRHSLGSCIDSILFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT0</accession>
    <name>A0A654DZT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_12186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025250">
        <property type="entry name" value="DUF4199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13858">
        <property type="entry name" value="DUF4199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="169" mass="19650" checksum="7665000A72FFA48F" modified="2020-04-22" version="1">MLKISIKYALICGVFITIIYHLSFLFNSNPLIDLSHLLFDLILFGLFIFFAEKEYKTYHGQGVFHFWQGMTMGFIVYTVATILFVGALIIYFQFSEDAVKNYQEAATHFLNERAEMYREQFGEAGLQEQMDEIRDVTMWDLVQSSALKKMLAGFFITPVISIILRKQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU5</accession>
    <name>A0A654DZU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="323"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="661" mass="75046" checksum="0705EE5BE84A0D06" modified="2020-04-22" version="1">MDFFKVHLFLLKWIKAISMNIYAKLTLLCVSLVFFTSSVLYFFVNRELERTFSEELLSNVTKQSEQTISNIERFVYSRLNELKIAATDPYFRQDNISQADLTRKLQELESLNDLYASFSFFNNDRLRIADSKSLSVGKTHSLSTYWTKISPTIDAVVDVDRSESTELNVMNFATVVKDPETREPKGVLVGSILVDELYKFMGDISLGENERQLSVTLLDEGGIILYTQDESKTVLQDKFADFDLIQKVKNASARVERIETEDQFLFVAKEQGYLNNVGNDWTLVVSIGKEEALLPLAEIQKKLLWVILLALGASIILALIVANIFVRPIVKLSKIAEDLGKGNLSAEIKITSNDEVGKLASQLSNASQVLIRRLDEQKKLNDKLEHQKNEMVAQKQLLEQANRQVSDSIIYAQRIQRSILPEITVLSKLVKDAFVFYEPKDVVSGDFYWFERVRQGRNEYLIIACADCTGHGVPGAIMSIMGSNQLTNIVYYQNYIDPNKILARLDKVIKFELKRDENQNQDGLEIGICIINLDDLKMEFAGAGIPLYLIKKGTNELITYKSPKFMIGGIEGDEKEVAGKLNKEEVQLEEGDKIYLSSDGFQDQFGGEHDKKFLSKNFKKLIEDISEKPMSDQIKDLENAFRSWKKNTPQTDDVVVIGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZU7</accession>
    <name>A0A654DZU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_120223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
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            <end position="338"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="387"/>
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            <end position="419"/>
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            <begin position="210"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
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            <dbReference type="RuleBase" id="RU362011"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51371"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD16448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="456" mass="50586" checksum="32805DB5ED71F180" modified="2020-04-22" version="1">MTTESIMEFALSKEFLERFQQALDEKDEAFIRQSLEGVNPADITALLYEFDSEECHYVFGLLPKEVDAAILNDLEEDVRVDFIAEFTPEELAKYIEYLDSDDGADILYQMSLKKREEVIRFIDNEEKASYILDLLRYEEDVAGGLMAKELIKANINWTIKQCIEEIRKQAENVQKIYSVYVVDDLGKLVGKVSLKRIILAEDSAKIADIYDDNVVSVETYMDEEEVAIIMRKYDLEAAPVVNARGKLVGRITIDDIVDVITEMAEEERQMMAGISADVEEDDTVWMLSKARLPWLIVGMVGGLLGAQFMGLFRGDIVLIPALAFFIPLITATGGNVGIQSSSIVVQSLANPNVFAGGIVQRLMKVLFVAVVNGVILALMVFGVVMMVNRNEPLAATVSIALFSVVLLASFMGTITPLILDRFGINPALASGPFITTANDLLGLAVYFSVAHLLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E002</accession>
    <name>A0A654E002_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_110111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="99"/>
        </location>
    </feature>
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        <location>
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            <begin position="306"/>
            <end position="331"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD15954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="390" mass="42639" checksum="A3F271B8ACCF26EC" modified="2020-04-22" version="1">MNVIKDWAYKNLKGDPVIWFIVFLLSMLSILVVYSSTGSLAYKMMEGDTEYYLFKHSALVMLSLLAMWVAHKIDYRYYAKLSRLALWLSLPLLLFTWQFGTNINEASRWITIPLINQAFQPSDLAKLALVITLASMLSKRQKSIDDFQKAIIPVLVWIGLICALIAMTNVSTAILLFGTCMLMLFIGRVPMKYLAILMIIGVIAGGLALTFGQRTGTAVSRVQSFFDEDETPFQAKQAYIAIATGGLTGKGPGQSDQRNYLPHPYSDFVFAIVLEEYGLIGGISVLFLYLALLYRGMKAAAESHRAYGGLLSAGLSFALVMQAMVNMGVAVGLGPITGLPLPLISMGGTSQLFTGLALGIILSVSRGEIDDIGSPLANNFKAKERIKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0M9</accession>
    <name>A0A654E0M9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 15" type="primary">rpoB</name>
        <name evidence="15" type="ORF">MARINOS108_120506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="308"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="473"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="551"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="680"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1215"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD17134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1289" mass="145250" checksum="A420FCC671E84B4F" modified="2020-04-22" version="1">MAKNTSERVNFSSIKSVIDYPDFLDVQLKSFVDFFQLDTPSEKRNSEGLYKVFMENFPISDSRENFVLEFVDYTVDPPKYSVDESIERGLTHSVPLKAKLRLLCNDEENEDFETIEQEVFLGNIPYMTAKGSFVINGAERVIVSQLHRSPGVFFAQSKHTNGTHLYSARIIPFKGSWIEFATDVNNVMYAYIDRKKKFPITTLLRSIGYGSDKKILDLFGLSEEIDATEKELKKVIGRRLAARVLRTWTEDFVDEDTGEVVSIDRNEVILERDGIISEDDIETILESGSKSIVLHRKDVNITDYSIIYNTLQKDNSNSEKEAVEQIYRQLRNTDAPDEQTARDIIQNLFFSDKRYDLGEVGRYRINKKLGLDIGYDKRTLTTEDIILIVKYLIGLINSKAVVDDIDHLSNRRVRTVGEQLYAQFGVGLARMARTIRERMNVRDNEDFKPVDLINARTLSSVINSFFGTNQLSQFMDQTNPLAEITHKRRMSALGPGGLSRERAGFEVRDVHYTHYGRLCTIETPEGPNIGLISSLCVHAKVNQMGFIETPYRDVVEGTVDMTGSVNYLTAEEEDTYNIAQANAPLDDKGNFLNDKVKARFEGDFPVVDPKDLKYMDVAPNQIVSVAASMIPFLEHDDANRALMGSNMQRQAVPLLKPQAPIVGTGLEKRVAIDSRALVIAEGDGEIEYVDAKKIVVRYERTEEDLLISFNSPSVTYELIKFRRTNQDTCINLKPIVTKGDKVTKGQPLCEGFATENGELALGRNLMVAYMPWQGYNFEDAIVISEKVVREDIFTSIHIDEYDLEVRDTKRGEEELTSEIPNVSEEAVKNLDENGIIRIGAEIKEGDILIGKITPKGETDPTPEEKLLRAIFGDKAGDVKDASLKASPSLRGVVIDTKLFSRPKKDKDLRSRTKKEVEMLKNRYSGELTEIRNQMIDKLAKLLEGKTCQGIKHKFGEEVMSKGTKFNRKNIEANLFPPKNAYRDESNYNVPEEANLISDLIIEDWATDQHTNDLIFKMVKNYINARNEVSGIFKRERFTLEVGDELPAGIVQLAKVYVAKKRKLKVGDKMAGRHGNKGVVAKIVRDEDMPFMEDGTPVDIVLNPLGVPSRMNIGQIYETVLGWAGLRLGKKYATPIFDGATEDEVQNELKEAGLPSFGRTYLYDGLSGVRFDQPVTVGVAYMLKLGHLVDDKMHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAFGAAHVLQEILTIKSDDVIGRAKAYEAIVKGENMQKPNIPESFNVLVHELRGLALEITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N8</accession>
    <name>A0A654E0N8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_120180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="373"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="757" mass="86626" checksum="F182EFB3CCA5CDA5" modified="2020-04-22" version="1">MREKFNSFIYSFPVQLVFHHIRRNLALVILWILFIATLGGGIGKIYGIHYLYLDPEYMNKVGFWSFFLVGLAFGNFTMAYHITCYILDSHRFTFVGILERPFAKFSVNNSLIPLIAFVVYVVLIVRFQVNNEFAGATNVIMDLLGLLLGIASMLSVFFIYFRFTNKDIFKYLAGSVDKRLRKAKISRERMMNKLTETRERRYTVHSYLDLKLRVMSCKNLQDFYDKEAVLKVFDQNHFNSVVIELAVIFLILFLGTFMDNPYFQIPAAASSLLLFSFLVMLIGAFSYWLRGWGLAFVFGLFLLVNMLVRWGVIKGEYQARGLSYDSPKVTYSLSKLNAMNSQEVFAADSLRMIEVLENWKAKQDSDQPQMVFLCVSGGGQRAALWAVNALQKIDSTIGSPIMDKTALITGASGGMIGAAYYRELELMRKRKQAIPSEPEQLARMGRDNLNAIIFSLLVNDAFFRVRSYEYAGRKYLKDRGVVFEENLNNNLGRVFDKRLIDYEGPEAEGLIPLMLMSPVIANDGRKLYISPHSVSFMNINNEELRDNDYKIRGVDFNQLFSGHGANDLSFLTALRMSASFPYITPTVSLPSHPPIEIMDAGISDNFGVGDASRFIYVFRKWLEENTSGITLLIIRDTRKNAPIEPRTNSSLVDKLTYPIASVYNNLGNIQDINNESKIEGLSTWLHLPVNVVEIEYNTYTNISEQYLVTSKELERKQLERASLSWHLTTREKQNIIQNIELPNNQKALMKLREILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Z1</accession>
    <name>A0A654E0Z1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025401">
        <property type="entry name" value="DUF4374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14298">
        <property type="entry name" value="DUF4374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024915154" evidence="1">
        <location>
            <begin position="26"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="419" mass="46170" checksum="B25B458EFE9D5002" modified="2020-04-22" version="1">MKNIKLSVWALLSSFFILSTTSCEPSDEPDPDEGEEGWSGYVVGLRATEGDASADYIVSVDDLMSGVITSEGQGIEQSGWSYYTAVGDNYLSIGYTLNECIGYKVDAGELYLNSKFVFERIDCVGSLEGDSFLAIGAPWGGGSYDCQLQVVDAGDVAITKTVKHPIYESYFYVDSLDEEVRLNAWPTSTYLAGDKLYVSFYPLHGTSWETPLVDKAYVTVYSYPGLEYLKTFEDDRTSPIGYYGGQPSLVTTESGDIYTISSSSYFAGFTHVSQPSGVLRIKAGATEFDQDYFFNVEEDYGYKIQNAVYAGGGKAVARISDPENDTGREVQWAGFGNFDVMEVAVIDLEARTLTRVSDIPVHAGQYQTPYLVEDGKVYMSIRQNETGKAYVYRIDPETATAERGAEIEGIELQGIFKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E140</accession>
    <name>A0A654E140_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane lipoprotein-sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024943662" evidence="1">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="209" mass="24031" checksum="C2D43883D66EFFB1" modified="2020-04-22" version="1">MRKLIYLIAAVCFAFNTQAQYDPDALAVLNAMSAKYKKIGAYSADFSQELINESAEINDKISGNILVKDDKYVLKVAGQEIYNNGTDVYSYSAELDEVTVNTYQPEDEEITLGNIYDLYKDGFKYVLMSVNKDGSRIVELDPVSKDKSYYKIRLQIDKNDDLKKFTVMERSGNKYIYTIEKFQVKNDVKDSFFTFDESKYPGVEVIDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1L7</accession>
    <name>A0A654E1L7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">moaCB</name>
        <name evidence="6" type="ORF">MARINOS108_11708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012247">
        <property type="entry name" value="MoaC_MogA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036594">
        <property type="entry name" value="MoaC_MogA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="5">
        <location>
            <begin position="149"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="299" mass="32234" checksum="933AFF3034B21AFC" modified="2020-04-22" version="1">MVDITHKSNTLRIATAQAIVKVSSEETIRMIHEGAIPKGNVFEMSRAAGLLGVKKTPDLLPDCHPLPIEFTGITYEISGLEIKILMTVKTIYKTGVEVEAMHGASIVALNMYDMLKPVDKGVEIHHIKLISKKGGKSSNPPQTKGITAQVVVCSDSISAGEKEDRAGKAICERLKGFGLTDITYRVIPDEPDQIRGIIERNEAALLIFTGGTGAGPRDQTPDTIAPLLETRLNGVEETMRRYGQERMPFAMLSRSLAGIRKGQVILAVPGSTAGATEAMDAVFPGLFHIFHVLKGGGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N3</accession>
    <name>A0A654E1N3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024896036" evidence="1">
        <location>
            <begin position="27"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="731" mass="84219" checksum="9880DD86502D4EBF" modified="2020-04-22" version="1">MRITTVINLFLIIVLLSCSDAQDQRAEDRPKEKTVFQTSNPWKPVIDVRADVAIVYSVKDHHENGGMTFEERVQSWRDRGYTTHFMSGIAWGEYQDYFTGKWDGKWHLDEGQVTQQGDTIWHGHMVPYIVPSTNFIQYMKEAVIKRVIDAGIDAIYLEEPEFWSRSGYSEAFKREWKEYYGFDWRPQHESAENTYLSNKLKYHLYYRALNECFTYAKAYGKSKGMDVRCYVPTHSLVNYSQWMIVSPEASLASLPCVDGYIAQVWTGTSREPNYFKGERKERVFETAFLEYGSMESMTAPTGRKLFFLTDPIEDWPRDWADYKKNYQATFTAQLLYPMIANYEVMPWPNRIYQGLYRTSADSDEKERIPRFYSTQMQVMINALNHMPLSENKVSGSQGIGILMANSLMFQRFPTHAGYEDPQLSNFYGQALPLLKRGVPVKTVHIENVSFPETLKDIRVLIMSYSNMKPMEETAHGYLAEWVKAGGTLVYSARDEDVFQRVQDWWNTGENDFKAPSDHLFENLGLDVPLEAGEYQYGEGLVRVLRNDPKEFVLEAGSDDDFVSAIDALYRKTTGEGLAFKNNFALTRGPYEIISVVDENADVTPYTLEGMLIDLFDPEIPVLTTKVINPGEQALLFNIDRVENRDIPQVIATAARVYDEEIAEHSYAFLVKSPLNTTNVMRILLPKKVADIKVIDHFGEAMKVESSWDEVSKTCFLRFDNNPEGVHVSVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1P5</accession>
    <name>A0A654E1P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="73"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="250" mass="28975" checksum="B7F5F4B941D279D6" modified="2020-04-22" version="1">MKHSPLPYTLYALFIFLMTSLVFVPLIALLSPYKKCHRLALKLHWYWAWSFCRMAFIRVVIEGKEHLRSDQQYIFCCNHFSFFDIPAFCLLYSAKFIGKSSLAKIPLFGFFFRNMHIPVNRSSMRSRAGSLKMSKEAIDDGFNLCFFPEGGVLVKEENLPYMVSFKDGAFKLAIEKGIPIIPVTMPYNFLLLPDKTPVRFHHHRCKIIVHKPIFPKTSDDEEVKRLKAETFAIIQAELLAHHPDKVRTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1S4</accession>
    <name>A0A654E1S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024950606" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD14112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="163" mass="18521" checksum="5EE72B6154C88D5B" modified="2020-04-22" version="1">MTRLLLHFMILLVAMGSCEEDQDEQQAYFEYFGVNHAWGFQYSHWIIDGAGNVRVSSYADSVVWLSGGLDPHISKFDSVIFQVSKTELDSQIAKIWPASKGPVETIEQHRNDFGAYGFNAFYQDKIIPLSLRSDTEDKTNNSTEAAQLILWLQDLQEKLPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1Z0</accession>
    <name>A0A654E1Z0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease E/G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="516" mass="58449" checksum="9C1A8424725AFEAC" modified="2020-04-22" version="1">MSNELIINSTQNGCRIALLKNKQLVEFHQESDGNRFNVGDIYLGTVKKVVQGLNAAFIDIGYEKDAFLHYLDLGPQVQSLNKFTKLALSKNSMSAKLSGFKHEPDINKLGKISQVLTKNQKILVQVVKEPISTKGPRLSCELSLAGRYLVLVPFSNAVNVSKRIGDANERKRLSRLISSIKPENFGVIIRTVAEGKDVKELDKDLKNLLQIWIDGVKNLKTANTRDKVIGEMNRANSILRDVLNESFDSIVVDDKELYEEVRSYVNKIAPDKEKILKLYQNRVKVFESFNIEKQLKTSFGKSVSIANGGYLIIEHTEALHVIDVNSGNKSNQEDNQETTALKVNLEAASEVARQLRLRDMGGIIVVDFIDMRKSENRKKVYDRIKEVMKDDRSKHTVLPLSKFGLLQITRQRVRPELNIATREVCPTCNGTGQITAAISIADQIEKTLDHILTAQNEKKITVTLHPYIHAYFTRGVFSRRVKWFLRYLKWVHLIEDSSLALTEFSVLNNRGEAIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E236</accession>
    <name>A0A654E236_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025632">
        <property type="entry name" value="DUF4290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14123">
        <property type="entry name" value="DUF4290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="231" mass="27345" checksum="C7239C9572E90DA4" modified="2020-04-22" version="1">MSLEYNTQRPHLTLREYGRNVQNLVKHLKATDDKEKRNKYAALIVELMKMINPEFSKDASEYTQKVWDDLFIISKFDLDVESPFPIPESTILERKPDRMRYQSNEIKFRHYGRNIEILINNAIALEDPEEKEAAIVAIGKLMKSFYLTWNRDNIEDEQVLKNIKQLSKDQLDIDIEKVKANGLFDSSERKERSFDNNNRGQHQGQNQNRNRNNNNKGGKRNFSNKRRRNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E275</accession>
    <name>A0A654E275_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="17999" checksum="85FA63593C84701D" modified="2020-04-22" version="1">MRSGIVLMLGVWLVISCHEIKDCTLETSTDYSIVRFYRADTTVKTVKEVAFSKIYEPDVSGYYISSMEDTIDDDTIVVTGLFLNPADTRVTYLFETDSIDYELTMEYKPHLRIYYDECDPVYSYKLDTAYSPHFDSVAMVNNVLDKVVVTNLEIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A6</accession>
    <name>A0A654E2A6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="165" mass="19102" checksum="2FC7D145587CF63F" modified="2020-04-22" version="1">MKGIFLLLGSNLGDRMQNMQRAKDILAAHEINISDFSAVYESAPWGDENQGWFLNMVLKIDTIHDPESLLQSCLDTEIQMGRTRLKKWGERIIDVDILYYHDVVIESPHLRIPHPGIAMRRFTLMPLVELAPHEIHPVLKLPQKQLLEICPDMLECHKTDLYLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2G0</accession>
    <name>A0A654E2G0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="61" mass="7003" checksum="EA747FF9E4F91051" modified="2020-04-22" version="1">MGDRKNKISRGLNKLLNSKKTNEFFQNDDVFVGNPSMRNSYFDSFYQAQLTEIAYSGQSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2R5</accession>
    <name>A0A654E2R5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjbQ</name>
        <name evidence="2" type="ORF">MARINOS108_20220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15900" checksum="31F9CFEA61CEF415" modified="2020-04-22" version="1">MKTFQQTIHLQPFSRGFHLITRDVLNAIPEIRELKTGMLQVFIQHTSASLTINENADPTVRMDFESHFNQMVPENAPYYQHNYEGPDDMPAHIKASLLGPSVLIPITNGRLNLGTWQGIYLCEHRDYGGSRHLVLTAWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S2</accession>
    <name>A0A654E2S2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">suhB</name>
        <name evidence="7" type="ORF">MARINOS108_20373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="29383" checksum="8D6296F840C34C0C" modified="2020-04-22" version="1">MTIDLENIAQLVARLTRDTGAFIRQEASAFSIEHVELKGKSDLVSYVDKETERKLVTGLKEILPEAGYITEENTIAQDRRAYTWIIDPLDGTTNFVHGLPTYAISIGLMADHEVVLGVIYEINRDECFVAWKEGGCFLNDQKISVTEASAIDDSLFATGFPVHNFEKLDAYLAILNELMKNAHGLRRVGSAAVDMAYVACGRYEAFFEHNLNPWDVAAGVIIVQEAGGTVTDFQGGNEFLFGREMVAAGPVHGELLRVIQKHWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T2</accession>
    <name>A0A654E2T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="458" mass="50908" checksum="196E77148D598785" modified="2020-04-22" version="1">MKNFLPLLFILLTGILACEPEEEKITTSLDVKLAFSTDTVLFDTLLTERLSVTKRLRIYNPNDKAVKIHDIRLGKGRASDYSMIVNGQSGTTIKDQVLFGGDSLLILVSVEIDQQNKDLPYLVKDSITVSWGKYLANVKLVAYGQDANFVNSRLICDEVWTADRPYVIYNFALLDSLCTLTVQPGTKIYLDNGASFFVQGSLKILGDSGRHVTIRNTRFDPDYLEAPGQWGGIYFLEGSKDNEIRYADIENGEIGLRVGTPDDDEKYDLEISHTTIRHMSVAGILAFSSDVYAYNTLIHNAGGFLVGNLAGGNYKYEHCTFTNVPSFFISDDPMIQFSDNVILADDDVLVGDLSVEITNSILWGEGVNQLFVGDGGGATVVTKIQSNIIKSKEDWPDNYVSQERNYPGFKDPFTFNYQLDSLAFARDKGVNISISDDITGHLRDSKPDIGAFERIDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E310</accession>
    <name>A0A654E310_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_110008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="397"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD15832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="513" mass="56402" checksum="CD407DB2E122D57D" modified="2020-04-22" version="1">MNIYIMIRNIVFTFLLVVSFLCGAQVQFFGSPESLKPLNTPSSENYIFLDFDNSQLYFSRAHFAGNKGGSKDKGDIWVSAYDSAWATASNMSLNDDQFTAPAGLTPDGRYFLFHKVWFSVGMHYGGVFAKPLDGGEVFQVDIPFFKNRSPIQTGTISADGRYLLLSLENNLGYGVDDLFMCRLQPDGSWSAPKNLGNVVNTALQELTPFLAEDNKTLYFASNGLGGQGSFDIFQSRRLDDTWQNWSSPVNLGSAVNTPGAETSFAFSSDSDYAYFVSTQNSDGYGDIKRIRITSDIVAEVRNDTVVSMVATAEVEVFLTVYLLDKISEAPIQGTGQVVLEGDTSLYSTNGKGEIQIPDLGQPLNFEFKADGYLSSKRILSRDDFASGVSAKVLLDPLSTGNTITLEHVLFYRGTANFVEGSEEELDLVVEMMNENPEVKIFLKGHTDNVGNEQLNVYLSKERVIAVTEYLVSRGIAAGRISGEGYGGSQPVASNADEASRKLNRRVEFEVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E366</accession>
    <name>A0A654E366_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">nadK</name>
        <name evidence="6" type="ORF">MARINOS108_20523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32438" checksum="EEF8928B264B6F10" modified="2020-04-22" version="1">MRKIAIHGRRISPDSASYVRDIVKIIESNGRKIFVSPEMSAISESKEIFKNYPHYVPGKDMETFEAVFSLGGDGTLLDTLTHVGSSQLPILGINLGRLGFLAVISRENIRDALTAYFAGQFTYEDRSLLALETNVPLFNGKNYALNEFAILRKDTSSMIVVKCYLDGEFLNTYWADGLMIATPTGSTGYSLSCGGPVIMPNTSNFIITPVSPHNLNVRPLIISEDSELIFRVESSNQSYQVSLDSRSESIDDQIEFRIKKAPFTSRLIKVEGSSFLDTLRNKLTWGLDKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3F9</accession>
    <name>A0A654E3F9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">MARINOS108_20802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="289"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="461"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD19651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="612" mass="67121" checksum="042936FAF662F238" modified="2020-04-22" version="1">MCGIVAYLGDKPAFPILINGLKRLEYRGYDSAGVALMEDGNLQIYKKQGKVKQLENLTNGHSFDSTVGIGHTRWATHGEPNDRNAHPHYSSNHRLAIIHNGIIENYGALKTELEEEGYSFESDTDTEVFITFIEDIQKTLGVSLEEAVRVALTKVVGAYAIVIMSQDDPDKLIAARKGSPLVIGLGKGEYYVASDATPIIEFTNEVVYLNDEEIAVITRAGFEIVNTKDIPQKPYIHTLDLKLEAIEKGGYEHFMLKEIFEQPRSVADCMRGRINATEGRLMLGGIRNYSGALTNAQRIVIIACGTSWHAGLVAEYLFEDICRIPIEVEYASEFRYRNPVIREGDIVIAISQSGETADTLAAIELAKSKGAIVFGVVNTVGSSISRATHEGAYLHAGPEIGVASTKAFTAQLTVLTMIALSVAQQKGTISDVKFRELLVELESIPKKVAKALESDGKIKEISALFKDVHNFLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDENMPVVFIATRDSSYDKIVSNIQEVKSRKGKVIAIVTEGDVLIPKMADFTIEVPATHEALMPLVSVIPLQLLSYHIAVMRGSNVDQPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I0</accession>
    <name>A0A654E3I0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="303"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD18729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="525" mass="59717" checksum="12E1C14822F44FCE" modified="2020-04-22" version="1">MKRSTLRWVVTLMSLALLGLIGFQWYWIDSVIRANEERFKKDVIEALHTVSEKLEKQEALYAFNQSVYFSRTYGGTQSYQFRAAPQNTDVVVIKDTLRNDAMGFDIIFDFQVGSGGEQQLRGVPEPRAPGHQTWQHSKEMKDAERLLLEERLERATRKSEMVFQVLENMLVPDRSVMARFNPQQLDSLLSSEFAERGIDISFDYAIVSPMSERFLLVDNRASKRALEKSELKASLFPNDLIGEQNWLVVDFPEKQQFLLRKIWLTMASSGFLILVIVGSFGYSIRTILRQKKLSEMKNDFINNMTHELKTPIATISLACEALSDKEINQMKGMQDRYLAMISDENKRLGEQVERVLQMAALDRNDIELKSESLNLLELVERAVEKTALQVEARSGQIKVIDNADHKLVFGDKTHLTNILVNLLDNANKYSDSAPEIMIRLYNKAGDISVAVQDRGIGMTKEATTHIFQKFYRVPTGNIHNVKGFGLGLAYVKNMVELHHGTISVESEPGKGSKFTITLPNEHGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R1</accession>
    <name>A0A654E3R1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator in two-component regulatory system with CusS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cusR</name>
        <name evidence="6" type="ORF">MARINOS108_20912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="226" mass="25764" checksum="7C69D1DBE9026207" modified="2020-04-22" version="1">MMQILIIEDEVKVANHLKMGLEEQGFAADIAYDGNVGLRLFGQKAFDMVLVDAILPGKNGFEICREIRVQNSEVKIIMLTALGTTDDKVEGLESGADDYMVKPFDFRELLARIRAILKRNLPYTGKERLKIGDLLLDMERKTANRAGVNIDLTAKEYALLEFLMRNKGKVLSRMEITEKVWDLDFDPGTNVVDVYVNILRKKIDKQFENKLIHTRVGMGYYLDDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X2</accession>
    <name>A0A654E3X2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="92"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="29383" checksum="5B6577DFB05B2711" modified="2020-04-22" version="1">MRNIVIPFGISILLVLGSFNTVGITKYKVRKIVIDPGHGGKDPGTHGNISKEKDIALKIALEVGRVINDNLPDVEVIYTRTDDSFPKLHERSNLANKKDVDLFISIHANWVSNPSIYGTETYVMGVQNTAGNFEVAKRENSVILLEDNYETKYDGFNPESPDSYILFSLTQSAFQERSLRLAGLIEDQFKNRVGRKSRGVKQSSLWVLWNTAMPSVLVEVGYLSNEKEEKELNDPLNQVYIASGIYRAFRDYKMELESMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3X5</accession>
    <name>A0A654E3X5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tyrS</name>
        <name evidence="9" type="ORF">MARINOS108_10720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="432" mass="48215" checksum="6AEE28867916F2B7" modified="2020-04-22" version="1">MKDFVAELKWRGMIQDIMPETDEHLMESMRSAYLGIDPTADSLHIGHLVGVMMLKHFQQCGHKPYALIGGATGMIGDPSGKSAERNLLDEKTLRHNQDAIKSQLSRFLDFDSDAPNAAVLVNNYDWMKDFSFLGFIRDVGKHITVNYMMAKDSVKKRLSSESSDGMSFTEFTYQLVQGYDFLHLYKEAQCTLQMGGSDQWGNITTGTELIRRIGGGKAYALTCPLITKADGTKFGKTEGGNIWLDAERTSPYQFYQYWLNTSDADAEKYIKIFTFLSKEEIESLIATHREAPHQRALQKKLAEEITVSAHSQADLEMAIKASDILFGKSTTEDLTAINEKTLLQVFEGVPQVEISKAEYEAVANVTDLLSELTQGVVFPSKGEARKMIKGGGVSINKVKVESSEAAVNYDLLQGKYLLAQKGKKNYYLIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E410</accession>
    <name>A0A654E410_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-amino-4,6-dideoxy-D-glucose transaminase</fullName>
            <ecNumber evidence="4">2.6.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vioA</name>
        <name evidence="4" type="ORF">MARINOS108_50007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.33" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019179">
        <property type="term" value="F:dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="357" mass="40694" checksum="DD00B7F3558C1422" modified="2020-04-22" version="1">MIPITQPFLPKKDEYQKYINEIWENNWLTNNGPNVRQLEDRLAKYLKIKEMLLVNNGTIALQLAIKVLGMKRKVITTPFSYVATTSSLVWEGCEPIFVDIDPDSLNIDPERVEEALGHGVDGILATHCFGNPCDVESLEFLSESRGKKLIFDAAHGFGSKYKDKSLFEYGDISISSFHSTKLYHTIEGGGIFSKDERWLEKVAFMRNFGHDGSEKFQGIGINGKVSEFHAAMGLVNLNYIDEILLDRKKLSVFYDTLLQHSGVRRPIVSSAGESNFSYYPIIFESERILLEVKKRLEESDIFPRRYFYPALNSLDYVKSQSCPIAEDISKRILCLPMYYGLTESDQEKIAEILLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E436</accession>
    <name>A0A654E436_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="30516" checksum="8DA9287260D02515" modified="2020-04-22" version="1">MNKFSDLYQRIISATAGAAIIVSSLIIGEWAYFVVFLTISLLAQWEFYRLIKLQSYLPIRLLGVAIGGGLFILSFFVARGSLNSNFYFIIFPIASLIFLIKLYKKNDNNPFLNIALFYLGLTYVALPFALMNVVVHYHGWYSYEILLGLMLIIWASDTGAYFAGIRFGKRKLFERISPKKSWEGAIGGALTAVAFSIAISRYSTGLAMWQWIIVSLIVVIAGTYGDLVESMFKRTMQIKDSGTSIPGHGGFLDRFDSLILAVPFIVVFLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E448</accession>
    <name>A0A654E448_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="59"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="32160" checksum="CFC8E4223E3F418D" modified="2020-04-22" version="1">MKISRKKALKNMAGLSALGFIGFPEFGHSQSIKEMKGKINHSVCRWPYGKNTLEELCEAAKEIGISSIELLNPDEWPIVQKYGLTCAMANCVPLSLTDGFNDPKLHEQLKKDYFDLIPKVADAGLKNIICFSGNRNGMPDDLGMENCAIGLEPVVKKAQEYGLTICMELLNSKVNHPDYQCDHTEWGAGLCEKLGMENFKLLYDIYHMQIMEGDIIATIQKYHPYIAHYHTGGVPGRNEIDETQELNYKAIMEAIVATGFTGYVAQEFIPKNEDVFASLAQGVRICDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4A2</accession>
    <name>A0A654E4A2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_60005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024884042" evidence="1">
        <location>
            <begin position="28"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="29324" checksum="0615B289F5A18E65" modified="2020-04-22" version="1">MMQFRYRQNLSVLLVFFFCLVASRLDAQPKDTLRVLFVGNSYTYFWNLPQMVAAMGASRDFPVMARKSTAGGASLRQHWDGEKGLKTRQLITQSQWDVVVIQNHSLSSIDTPEEFLSYGQKFIDLIRESGARPMLYETWARAYNPLMQEKISAGYSNLGKVSTTEVAPVGQVWAQVRSLRPDLELFHDDGSHPSTAGTYLTACVFYAMLTGESPIGLADRIKITDKNGEELYLAMMGKDNAEFLQTVVEAHILNPEHIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F7</accession>
    <name>A0A654E4F7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">folD</name>
        <name evidence="11" type="ORF">MARINOS108_20983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="124"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VXD19966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="31342" checksum="B866DD7904E96F4D" modified="2020-04-22" version="1">MPTLLDGKKVAGDIKNEISARVQDLKSKGKRVPNLAIIIVGDDGASHTYVNGKIAACKSVGFDFTLMHFASTISEDKLIKHVENLNADEDIDGFIVQIPLPEHISVERVTESVKPEKDVDGFTNQNFGSIVSKHQLIMPATPFGVVELLRRYKIETEGKHCVIVGASRLVGAPLGMMMTEDGKATVTLCHKYTRDLSSHTKLADILIVGVGKPGLITADMVKDGAVVVDVGTTRIEDKSRKTGFRLAGDVEFDTVAEKCSFITPVPGGVGPMTIASLLLNTMKAYEDQHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4K2</accession>
    <name>A0A654E4K2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">tdk</name>
        <name evidence="12" type="ORF">MARINOS108_20534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD19032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="197" mass="22310" checksum="3AF9A445F353CA13" modified="2020-04-22" version="1">MFVEPNIGGRSISKAGWVEVICGSMFSGKTEELIRRLNRVLIAQQNVEIFKPTIDKRYSKKKVVSHNENAIHSTPVNFAHDILLRAGHCDVVGIDEAQFFDDEIISVSNELANQGKRVIIAGLDMDFMGKPFSPMDQLMATAEYITKVHAICMECGNIASYSYRRTKSKQTVVLGEKDVYEALCRKCFYEKMDHKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P7</accession>
    <name>A0A654E4P7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018577">
        <property type="entry name" value="Restrct_endonuc_II_Bpu10I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09549">
        <property type="entry name" value="RE_Bpu10I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32988" checksum="1953C4A53E60F839" modified="2020-04-22" version="1">MSHLSNPKSKNLYKQQLDRLNDIDPNLPHGSNLKTKLLSGKQSVVLSSIADAYLNFLNGINNITTTDQTEWLKQSLSIFENYYAFLKAPENKKFSHQSDFLSSLLPELLYLSYSKIIQSAHSDLEITTQKDIIIDLSFLPYNDSSITFKPKRVDVAIVKKLDVTIGGEALDFSIPIVALEVKTNLDKNMISGVEYSVERLKRTFPLCKFYLVSELADFAYEKQNYAGTAIDEIIILRKQKRSVVRKNPKGINNVDLGLFESHINDIHEFLNSNVVTPSNLKERLSTGRLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U1</accession>
    <name>A0A654E4U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Omega-amidase YafV</fullName>
            <ecNumber evidence="2">3.5.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yafV</name>
        <name evidence="2" type="ORF">MARINOS108_20624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="263" mass="30128" checksum="4F98C74AF5520F3B" modified="2020-04-22" version="1">MTDELKIALIQSDIHWENTEANLGMFEEKIWKLESKPDLIVLPEMFTTGFSMKAAELAEVAHTKTFRWMKQQAAQTKAVIMGSYILREGESFYNRLYVVYPDGSSQYYDKKHLFGLAGENAGYTAGTERLIVEVNGWKLMPLICYDLRFPVWARSRATENSLYEYDVLVYVANWPEPRIHAWDTLLAARAIENIAYCMGVNRLGTDGVGAQYVGHSAVYNFKGEVMAFSEKEENLTATLSAADLQSFRDRFPFQRDADRFSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E516</accession>
    <name>A0A654E516_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High-affinity gluconate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gntT</name>
        <name evidence="2" type="ORF">MARINOS108_90123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="435" mass="46071" checksum="423CDDDE6135F85C" modified="2020-04-22" version="1">MLIILLCIVILVLLITWARLNPFLAFIIVSILTGLLLGVPLQEVTTIVEQGIGGMLGGLVIVIVLGAMLGKLVAETGAAQKITNVLMSVFGEKKIQWALMTTGFVVGIPLFYNVGFVLLVPLIFSVSYQFKIKAVYIGIPMLAALSVTHGFLPPHPSPTALVGQLNADMGLTLIYGFCLAVPAIILAGPVFAKTLRNIEAKPLKTFQAEAKPEDQLPGAFNSFFSALLPVFLLGGAALVQLFWAPAGLAGQIIGFIGDPSIVMILALAYATYSIGLQQGYGMKGVMEFYTDAIKDISPILLIVAGAGALKQVFVVSGVSIELVSGLQDMNIHPLVLGWLIAAIIRVCIGSATVAGLTAAGILAPVMGQVDVDPNLMVLSVGAGSLLFSHVNDSGFWMYKEYFNLSIKDTIRSWSVMETIVSVVGLIGVMILDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E554</accession>
    <name>A0A654E554_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative outer membrane starch-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025005483" evidence="6">
        <location>
            <begin position="20"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SusD-like_3" evidence="8">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="7">
        <location>
            <begin position="272"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="510" mass="56068" checksum="81360C207B391DE2" modified="2020-04-22" version="1">MKTKYINISILLGAMHLFAGCSDSFVNVEPKGTALEENYYRNAEEAFNGVVAAYDPLGWTNGFVVKTGCLNAASDDFFAGGGGPTDINAMQVWDDYSLDPVTGPQGEFWNRNYSGIFRSNILIQKLPDIEMSQALKDRYMGEVLFLRAYYYFDMVRLFERFPLITAPIPTSEIFEVESSDRAAVFALIEEDLTEAIDLLPGTISGMEEAGRATRGAALALLGKVYLQQDKFGPAATELAKVNGTPGGANEFGYDLVDNYADLFTLDNEFNSESIFEISHNSTSQGNWGCIACTEGNPMSIMVAPRGYVINDPSQAPTYVSGWSFNTVTQSLVDAFVQGSVYDPRYATTITNIDSLEQLGIVSYTHAHENTGYFLAKFAGKEEEKTADGTVPFEINFGTNEYEIRLADTYLLEAEALVRGGGNVARAQLLLDAVRARVGLTPVPATFENIVAERRLELAGEGHRWFDLVRWGMAAEKLGPRGYEDGKHDALPIPQSELDFSGTKLEQDPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E563</accession>
    <name>A0A654E563_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_50009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD20495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="377" mass="42440" checksum="4763B0267309AF98" modified="2020-04-22" version="1">MWYGMKDIGFELIGRDRNRTLRKEEFWAVKDVSFELRRGECLGLIGHNGAGKSTLLKILNGLIKPDTGRIEMRGKVGALIELGAGFNPILTGRENVFINAAVLGFDKKEIEEKFDEIVEFAELEEFIDTPVQNYSSGMKVRLGFAVAAQLEPDILIIDEVLAVGDIGFRLKCLNLLDRLIANCSVIFVSHQMPQVSRLSNQLMLLDHGKVVYTGSNVPSGIDQYYSMMSTKGLEFINTEGGVELLQIGIQNAQLTQGTLSVNHGDDLVVEIRLKISNQYANPKIHLIVFDLEQRPIGLIWPKEDIPNDKITRIDSEFSEIHLNLKTDHINLSKGIYSLTLSVTNDGERVLRISSVLTFQILSDRDIWQPIEFESYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E581</accession>
    <name>A0A654E581_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA</name>
        <name evidence="9" type="ORF">MARINOS108_50058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="22131" checksum="0334D5E882CF0045" modified="2020-04-22" version="1">MAFELPDLPYAHDDLEPHIDKQTMEIHHGKHHAGYVAKLNAAIEGTEMAGLSLEELLTKHSSNGAVRNNGGGHWNHSLFWTIMGPDGGGNPSGTIMDAIHDSFGSFEAFKEKFSNAAATRFGSGWAWLCVHPGGKLEVCSTANQDNPLMPEAGCGGRPILGLDVWEHAYYLKYQNKRPDYIDAFFSVINWSEVNKNYEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5A6</accession>
    <name>A0A654E5A6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="60" mass="7099" checksum="3E0C81258A990426" modified="2020-04-22" version="1">MKSLEHLEESLLKVKKKVKKEQKVAKKLLKHLLKDNPNFHCNKRILPRAIRVGFFILAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5B4</accession>
    <name>A0A654E5B4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative secreted protein (Por secretion system target)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="5">
        <location>
            <begin position="85"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="743"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="981"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1222"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="6">
        <location>
            <begin position="1460"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1787" mass="190200" checksum="824C8D395BB886D4" modified="2020-04-22" version="1">MMKTFISIIMVIWAYCAMAQNPIVYLKYDEASGTQTALDEAGGLSFQVANTFNKPERVSGVAGKALRTDGFSTWASRDLTTNFGGTMTVETWISLESYPSDHEVPYGNLTPSAIISQMQGDQGYQIGINTFGVYWFSVNVNGLKYTCQAPNPFPLYEWVHVAGVVDAGASVMRLYLNGQEVASASIPNGGTIQEASAPLIIGKSNVDTYSGIFLINALNAAIDETKIYDIAKSGTAISSAYQALVANIPTSGFESLAVPSSRFANDVQRPVYHAMPAANWTNEPHGMVEYNGQYHLFYQRTPNGPFKTMMHWGHMISSDFVNWEHEKDALWPTLEWSSTSGYDMKGIWSGDVVVDNGTAHAFYTNVNHSGPYNPGISHATSSNGRLENWTKLGPVIDREVVADFRDPYLWKEGTTWHMIIGAKLTSGRGGLEYYTSSDLNNWTRQSQFTTLDYNQVAPAQSLWEMPVFESIGNGKHILIVNPIPGPGHTRAVYWTGVWSGGLFTPDYTQPKNLDVIHGHLSPTVARNTNGQLVGMGIVDERWDSQAQLDAGWCHTFSLPRVYTLLADGQTLGQSPAPELQTLRIPGTAITQTNLSVSGTQKIQAKGQSMELIVELNPNTAGDKYGVNFLVSDDGQEITRLYYDAVNKQVVLDKLNSSLSPRSFERLSFTEDYDETAFGKPEKFHIFLDHSAIDVFINGKAAFSNRIYPTMVSSNGVELYSDGGTTTFTSVQSYLLGAGGQGIGVTSVSLNKSSLILPLTTSGTLTASVSPATATNQQVTWTTSNAGVVTVVDGKLTPVAKGTATVTASAANGHSATCEVTVSDAPTYLVYDFESGNLSGWTVSGAAFATADVTSDIAWWGGLFQHQGTYHLHGFKDGGDGQVGSLTTSNFTLGSHGQIELLIGGGNDINNLFVGLYRASDDALLAKVTANNHETYSKVIIDGSAALGTVCYLKAVDNSTGGFGHLNLDDVRIPIQSGTPIAATGVSLNQTALTLAPQATFALEATVSPSNAANQSVTWSSSNTGVATVSSAGLVTAVATGQAVVTVTTADGGFTEQATVTVSNQEFLIYDFESGDLTGWTISGTAFVNADVTTAANWGWGGPFTPQGSYHLWGVSSGSDTETGSLRSQDFVIGGDGIIAFMIGGGFDINTVYLALVRKSDGVELMKATGDDNDSENYVSKQFDASAYIGVECYVRLVDNSTGGWGHINLDNLVVPIGNNNVPATGVSLNASSLTLTAGASKSLVATVTPANSTNKDICWSSSNINVATVNDGVVTGVSAGTATITATTIDGGFTAQATATVVAQDYLVYDFESGNLSGWTTTGSAFVSADVTTDVNWGWGGPFNQQGSYHLWSVKSGGDADTGTMQSQDFILDGNGVITFMIGGGFDLNTLYLALVRKSDGAVLMKVTGDNNDSEAYATRQFNAVDYVGTECYLKLVDNSTGGWGHINLDNVRIPVASVSVTGVDLDQASVILTEGHSTTFTATVLPVGASNQGVSWSSSNTNVATVDANGTVTAIASGSATITVTTNEGAFSDQTSVTVEAQQYLVYDFESGNLSGWTSTGNAFVSADATNAVNWGWGGPFNPQGTYHLWSVQSGSDADTGTLQTADFTLGGNGIITFLIGGGFDFNTVYLALVRKSDGAVLMKATGDNNDSEDYIQKQFDASAFVGTECYLKLVDNATGGWGHINLDNLIIPTVGNATARITEELEKVEETIVLRVYPNPVTDELHLDLPKESVYELSILSMDGREVRNQTLTGSTLDVRALNPGMYLVMVTTDSQKHVFRIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5R0</accession>
    <name>A0A654E5R0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="303" mass="34228" checksum="1B74F79E52BA59B7" modified="2020-04-22" version="1">MSSIQVKKQHTLTGHKDSLYTLCAYTDSAFFSAGGDGMVVLWDLKSPDTGKMIVKVPASVYGMSYNKERDILVVGQNFSGIHLVDVNTKKEIGSLALTTKAIFDIQTTSEAIFVATGEGEVFKIDWDLQILASKKLSVESARSIAVSAERKEMAVGFSDHHIRIFDTESLQLKKEFKAHEISVFSVRYHPQLPVLMSASRDARFKLWDLDNDYQMVEEVVGHMYAINHIEFGESGKYFVTCSMDKSIKVWDATEFKLLKVIDKARHAGHATSVNKLLWMNYRNWLVSCSDDRTISVWEVLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5V3</accession>
    <name>A0A654E5V3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_20118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="9">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="9">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="232" mass="27693" checksum="81A6152B6E0EED65" modified="2020-04-22" version="1">MKSLYLLLHIFTLAFPLIRSFEPRIQYAKKWPTLFPAIFITAAFFITWDIIFTQKGVWGFNENYLIGIFLWDLPLEEWLFFISVPFASVFIYECVRYFLPGIKTGRSFRILTVSMAFLLLVMAVINDQKAYTFWNFIFAGSFLILVALMNPHWLGKFWVAYSIHLIPFLFINGILTGSFLEQPIVWYNNRENLYFRIFTIPIEDFVYALLLLLMNITFYEVLNKYYIRIKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5Y6</accession>
    <name>A0A654E5Y6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="177" mass="20022" checksum="73B210BEEC761919" modified="2020-04-22" version="1">MKRLIILLLIGLCSTCQTTKSWYEITTNKTALQASELDNVPDSSQIIIAYSFLPASQLMNRMLEQLKDQNIDLQSSDRDKLTFSTSPTFIGQNTQYKMEVRLEPSEVELFKGKATIRTLYKEGGEVKGQAYAEDSRGTTFAANSQWQLAEKSDSRSGYAFFHAYQFAKSTANLIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6G5</accession>
    <name>A0A654E6G5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF4302"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14135">
        <property type="entry name" value="DUF4302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="457" mass="50155" checksum="78BEB940CA7C459D" modified="2020-04-22" version="1">MRKILLSLLIVSLFTACQEDETGLPSVENRVFTAIENLRDDLTDPSEGWKVLYQPTSASGAFFMIMKFKTDGTVTISTDLAANAGEFHEQTIPYRIDAGQGLELIFETYGALHYLFELDQASFGAEFEFIYEEKDDGDLYFRSKSDLNDPSSIVFTPANATDASAFSREIAANFDLYAGQSPRLFGGANPTQQLYLSDLDISVFWSVDLAKRTVLFDLAGSGSTLEEVLSGTHVSLNQSSGYTFMGGKIIFNQPIQIKVGGKGFELSELTLGDFSETGAPLCETSAEPTPVYSIPGGGSLTKNLFNSSGLGFEPQAGSLYSVNIPFIFDDSLRSLAEEGSISQKLPNALAFIMTYGFESDSIPANSVGFLVEDDQENSAFYLRSFTPTAVGNRLQIDWQDNYYYSSAPTPEEEAALTEILDEVFDGGSVYAYDLPIRGLTVYQFYNPCNGYEFVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E773</accession>
    <name>A0A654E773_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="149" mass="17111" checksum="F164AD9CF8A6D854" modified="2020-04-22" version="1">MIIDQLANCERYYALGERFQKGFEHLLSTDFSQVAPGKYELDGDRLKVAVQEYESKQEADCKIEAHQRYADIQFIYAGEEMMGIDTLRDQQPTVPYNSEKDVYFFGKYDYKIKVTAGMFTVFFPQDIHMPGLSLGVASNVKKVVVKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7I0</accession>
    <name>A0A654E7I0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="17" type="ORF">MARINOS108_20668</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="317"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VXD19304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="420" mass="46678" checksum="4E7D511BBA3611BB" modified="2020-04-22" version="1">MQRHFKAVGISYKNTPLEVRESVAFDEPQTRRFLVQLKEMLSVDEALVLSTCNRTEIYYFASENLNKEISGLVDVFHGISTTAPSAGYFKPFTHREAVRHLFEVALGLQSMVLGDIQITNQVKKAYQWAADENMAGPFLHRLLHTIFYTNKRVVQETAFHDGTASVASAAASVAEKFMVNYTAPKVAIVGMGEIGQNVAENLKGVNAEITLLNRTFSTAEAKAAELDYLARPFEELDAVLKDAHVIISAVQTPSPIIHAAHLSENSHPKLLIDLSVPRSIAEDVESVSGVLLYNVDQLQERASEALEKRKSAVALVSAIVTESIAEFDNWSQEMEVSPTIKKFKQALEDIRKQELARYTDKVDEAQAKLLDKATKNMIQKVIKLPVLQLKAACKRGEADSMVGLLNDLFNLEKEETKDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E8H4</accession>
    <name>A0A654E8H4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">crcB</name>
        <name evidence="10" type="ORF">MARINOS108_12177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD14870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="13409" checksum="14D19EB2204DF8D7" modified="2020-04-22" version="1">MKNILLVGLGGFAGSICRYLVTIYSLRVLAPSLPYGTLIVNLVGSALIGLLAGALLKMNNQFYQLLLITGFCGGFTTFSSFSIEGLRLLKEAQYYQYVTYVTVSVFGGLVLCLLGVWIAQKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E9F6</accession>
    <name>A0A654E9F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="95" mass="10667" checksum="4D774DA0FD21F08A" modified="2020-04-22" version="1">MSGAGFTKDMVNSSRGNRTLLKGNASATFNNFDREAYQIKPKKRKAPQYNQASKAYMKQLRNQLLADNLRTSRIRKLVLAGSVITGLILFSLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EAG5</accession>
    <name>A0A654EAG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="195" mass="22609" checksum="D9EC38D0617A40B8" modified="2020-04-22" version="1">MKSLLYAILVLVTVRLSASDPEKQTRMPMIKVYKNDLEKVYTVFFADTLVRTVKVSLQDKRGATLIEESFTAKGFSKPFGLTELKNGEYEFVISYDGTSVTEPIALRSEKEIMDASITLKRDYPTLMVNVSSYNMNPMNIFIYDNYDKLLKMLYWEPNDRMMTKNIDMSQFDGYEIRVQIVQDGIDKLEQLVPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBE8</accession>
    <name>A0A654EBE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024953571" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="157" mass="18533" checksum="BF98F96FBAB7C343" modified="2020-04-22" version="1">MQVKTIILSLLLSAACFRSFCQDSDYYNFLNPIQDSIYIYFVPDSTRYFISERSLIEGNLGIQYFIPMALGIDLCFTNNYYPESIYKNKLPLDSIVNLEVRDYWWLYQDMGMDRLLEKLNWGSTDFFLVVPDSAQQIAEIWHVFNCNNSSHVLEYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EBZ9</accession>
    <name>A0A654EBZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-hydroxyarylamine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="273" mass="32404" checksum="B426CEDCE8FFC93A" modified="2020-04-22" version="1">MSDLNYFQTRPKVPPIDTDLYLKRIGVQKDEPSLAFLKKIHRAHLLQIPFENLDIHYQRKIILDINSIYDKIIRHRRGGFCYELNGLLYHLLARLGFRAFLGSARVFQDGSISPEFDHMVVFVSLDEGNFLCDVGFGELFSEPKRLVTGNVQLDYTRYFRFEHNPDGEWLLRKSNDNSLYESIYVFTLQPRQMIEFLPRCNFHQESDQSHFTKQKLITQLFSEGRITLTDRKIKRSLYGEQKEREILNEDEFLAQLQEVFKINVRSLLRQKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EEE5</accession>
    <name>A0A654EEE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">clpP</name>
        <name evidence="8" type="ORF">MARINOS108_20997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="225" mass="25451" checksum="6E87F20DDFEAA0B8" modified="2020-04-22" version="1">MINKEEFRKFAVKGQGINGLTFDAYTDRVENMTRAVIEERPTNFREIDVFSRLIMDRIIFLGMQVEENIANIITAQLLFLESVDSKKDILLYINSPGGSVYAGLGMYDTMQYVSPDVATICTGMAASMGAVLMTGGAKGKRSALPHSRIMIHQPSGGMQGQSRDMEITLKQMQELRKDLYTIIANHSGRSYEDIERDSDRDYWMRASEAKEYGLIDEVLERNPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFH7</accession>
    <name>A0A654EFH7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ORF">MARINOS108_90061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="318" mass="34339" checksum="4C7EDFB5E8E088B1" modified="2020-04-22" version="1">MTKERVKVLIIGSGPAGFTAAIYAARAGMKPVLYQGGQPGGQLTITTDVENYPGYPEGIMGPQMMVDFQKQAERFGTDIRSGMITAVDFSGWPHSVTVDNKTEIEAEAVIISTGASAKWLGLESEQRLNGRGVSACAVCDGFFFRGQDVAIVGGGDTAAEEATYLSKLVNKVYMLVRRDEMRASKIMQQRVLNAPNIEVLWNSETDEVLGEEEVTGLRIKDTVTGEKREIEVQGFFVAIGHKPNTDVFKEFLDMDSAGYIKTIPGTSKTNIPGVFATGDAQDKIYRQAVTAAGSGCMGALDAEKFIAEKEVELQEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSE9</accession>
    <name>A0A654DSE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="865"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1451"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1550"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="2">
        <location>
            <begin position="1647"/>
            <end position="1751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="2270" mass="243983" checksum="3D5BB1289CB395ED" modified="2020-04-22" version="1">MKSLANCLQNRRKSAYQKLKSRFLKKLKSAQATSDRSAHLLVDRLRKLERQLGIHSSLSLRHWALAAAFGIITTAASFKSKARGSYTDYNSWYHRRNDLVEYQMAPNMMVQGDTASDLSAGPYLGDGLVLKEKIAADFDNDGDIDFVGFGYTEHALYVNDGSANFERFHFTPASDARFRAAVADTVDSDGDFDLLILEDIKGYSSSRIRFLENDGSGTFQGDSIIFDDSNYIRTLQIGDMDNDGDLDVLTAPWYGTGSFKYEFLVNTGTGFSRATLPRSFYHQTYSTNSDVVRLGDFDGDGDMDILTMPDSYFGANYYNASYYEAFEVFLNDGSGGFGTSVVTRFDINLNIWYSDSFFHDIKIADVDNDGDLDVIVGLDIDHPNNDRVGVSLNNGSGSFGPINAVVVNGSLNGFSVANFDDDADLELLVQSTEIFSPYSEITEVFDFGTNAFSTSLATLSASVGTFEDFVAGDFDNDGDDDLIATNELEAFQFDVESGNFNVVTNHLVQPIWAYNFELVDVDGDGDLDAIGNEIGQFLVNDGSGNFTLSQNLSDSLGFASPLVAIGDIDNDGDLDLVFAGEPHMGDEYYYTSVYPFEFSNGKFSPLAPVEVLMSSYSFEIHVMALANLDADPELELAIVSQEDYSSKYLQIHDFVSGNFSPTTISETSVANSEVESILIFDVDNNGVNDVVIGTGYSGVSVFENTNGDATFFTQKQDVTDGGSSVVALDTADFDGDGDYELLIAFNWPGSYEQRIAYNGSDTLAFSWVVQDVVLSNKAGITDANFADFDNDGDQDIVFASSDYGDTFMENTGSGFVEVMPAPYSSHRIAVGDVDGDGDIDLFVTESPEYGRVRFLFNQLPNLAPIISAQTFTINENSPNGSGVGTVIASDPEGKPISFAISSGNESGTFSLSGAGILTVLDSAALDYETTAVFSLGVDVSDGYNTSSNTITINLVDIDEAPIVTDQGFTVSEGASNAEVVGTVAAVDPESGTLLFTISSGNESGAFEIGSNSGEISVLDSTQLDFATTPQYVLNVDVSDGTSSVSGIITIDVSDFNYAPTVIDYTFSVDENVPNGTEVGTVDATDPDEDAMAYSITSGNESAVFAIDPSSGMISVLDSTQLDFETVAEYILEVSVSDGTNSVMSTVTIDINDINEAPSLAPYSFAIDENVASGTLVGTLEATDPEEDNILFQIMSGNESGAFALDPSTGALSVNDSSALDYESNTQFVLEVMVADLNNSSSNSVTIDLNNVNEAPVFTDQVFSINENIANGISAGTLIATDPEEDAVTFTIISGNESMAFSFDEVNGEFSVANSSLLDFESTPQFVFSIEASDGVFTVTSTATINLNDLQEAPEISDQSFSIDENSANGTVIGTVLGSDPESDALTFTISSGDDGAILIDSETGVLTVADSALFDFELQESISIEVQVSDGEFDATAIVTININDLNEAPEISNQSFSIDENSPTGAVIGTVLGSDPESDALTFTISSGDDGAMTIDAETGVLTVADSALFDFELQESISIEVQVSDGEFDTKATVTININDLNESTAPMIANQTFEIPENPEAGALIGVIEATDPGELPLEIKITAGNDNGLVSIVNGNELVVNDASAFNFEEASEMSFTVEATNQTESTTAIITVSILDINESPQIEDQVFRVEQGSASGASLGVIEATDPDEDALTYTIVDGNVSNAFAINASTGNLSVSNSSAIDFDVNPDFSLTINVSDGELSAGAEISVRVTTLERDKTALLEFFAATNGANWTASANWSSANTVSASWSGVEVTGGRVTGLRLPNNNIVGSVPESFADLTGLTVIDLSGNEINGFPNVSSSGNPSLNLSNNRLGITDLLKNVSLTSYTYAPQKRYGVARQDTIPAGEDYQVSIAEVKTNAGNSYQWYLEDVSIPGATSMTHMINDIDINSMGRYSLEVKNPLLPDLTLNTRRFSIWAATDVFGKVFANSQGTVLNNGQVDIFRIFDGPFQITDSAALASDGTYVIEDVVLGDFVLLVKPNRTVFPDVLQTYYVSTSDWDKADTLFLYEEAEGIDIQMVFYDEKTPTPGGASFVGTLESDFQDVIGGEDDRIDSRRKVKRAGCSMRRFVRAGRTEEDIYELYAYVESDDEGVFNFEGIPEGKYLLNIQYPGVPMDPNSDIEFIIGGDKENQKFQLRATITENGIVVEATEVLYTMKPYLKDLQLYPNPTAGVLKAEFFVYRKLNDLKMEVLDVSGVKLFEQALNPAMGVQSTEIDLTTFSSGVYFIVFTDESGTFRQQIKVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSJ9</accession>
    <name>A0A654DSJ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="16">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="16">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 20" type="primary">metG</name>
        <name evidence="20" type="ORF">MARINOS108_10035</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="16"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 16 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="12 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16 17" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="19">
        <location>
            <begin position="584"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="16">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="16">
        <location>
            <begin position="336"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VXD10402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="685" mass="77689" checksum="2F11EA76B73729D6" modified="2020-04-22" version="1">MSNKEFKRYTITSALPYANGPVHIGHLAGVYVPADIYARFLRLKGRDVAFICGSDEHGVAIELRARKEGVTPQQVVDKYHEQIKKSFEQFGISFDIYSRTSSATHHKTASDFFKKLNDHGKFVEQSSEQFYDPKAKQFLADRYIKGTCPTCSFPEAYGDQCENCGSTLSPAELINPKSMLSGESPVMKETKHWYFPLDQYEEWLRHWIVEEHPEWKSNVAGQCKSWLDNGLRPRPMTRDLDWGIPVPLEGAEGKVLYVWFDAPIGYISATKDWAASVGKNWEDYWKNEDTRLIHFIGKDNIVFHCVIFPALLKADGDYILPDNVPANEFLNLESNKISTSRNWAVWLHEYLEEFPDKQDVLRYVLTANAPETKDNDFTWKDFQTRNNSELVAIFGNFINRAVVLTHKYFDGKIPSRNELTERDEEVIAAIRTYPEKIEKSLEQFRFREASTHLMDLAREGNKYLADTEPWKLIKTDQSRVETIMNIALQLAGSLAILSEPFLPFTSDKLRKMLNQTEVAWSMAGGLGLMADGQQINEGVLLFDKIEDETVEAQVQKLMDTKKANEAANEVPKVAPAKDEVVFDDFMKMDLRVGEIKTAEKVEKSNKLLKFTVDTGLDVRTIVSGVAKHFTAEEMIGRKVVVMSNLAPRKIMGIESQGMLLFAENADGSLKAVSPDKDAENGAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSS1</accession>
    <name>A0A654DSS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="182" mass="20636" checksum="1065099B1AAE594F" modified="2020-04-22" version="1">MSDTKQDILNLAEHLIRSRGYHAFSYKDLSTPLQVKNAAIHYYFPSKKDLGAAVIRKNIEALENCFASWAGLPAREQLFNFIEIYSLNNQSNLICFMGALGPAYQSLPEEMRAPLTEAGLEIRNWLKWILNKGIEENAFHFNETIEEKADVIITSLLASLILNRVTGDRVLENVVSLIHKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSV2</accession>
    <name>A0A654DSV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="66"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27582" checksum="641CC0A9EF71D21B" modified="2020-04-22" version="1">MNYNRPAGWFFLNFVRVFRAGGCEFNLSENLFPSGYYSRFLFKTYESPEIALMKKYLDPGDSIIELGACIGVVSCISNKMLDHPENHVVVEANPDLITEIEKNRANNHCHFSLENALISNQAFETFYTYNIAISGSLQKKVHNPKLVLSREVQVKGVGFESLQAKYGLKFNVLLMDIEGAEYTLIEENLEFLKGLRLLIIEFHPNIMEHLDTEKYHRYLEEIGFEFAEKIEKTSVYIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTB8</accession>
    <name>A0A654DTB8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UnbV_ASPIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="535"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122626" checksum="98627A95E4EDE668" modified="2020-04-22" version="1">MNSTKTRAFCVVTLVISLFGCTNQEDPRQTLFTKVSPTESGVDFINDLNERKDFNLFTWKYIYNGGGVAIGDINNDGLADLYFSGNANANKLYLNKGNFKFEDITLSSGTKAAQGYKTGISMVDINGDGWLDIYVCRDAHPNENIRNNLVFINNKDLTFTEQGKNLGLQDKAYSTQSVFFDMDRDGDLDLFLVNHPADFDKAIQMRVSNENGDSRRITAPESKDQSYHLYVNNLGHFEDITEQSGLAYHGFGLSALAADFNDDGWLDLFVANDFIEPDVVFLNNGDQTFTPSYSGFDHMSQNSMGSDLGDMNNDGELDLIVLDMLAATNERQKIFATNMTQNRYERLADMGYGKQLMRNVLQLKTGPNAFSEIGCLSGIEKTDWSWSALFADLNLDGHQDLFITNGIKRDMSNKDFIDFNSDSIQRARQQGVDVFNRETVLDWIDLIPSTPLPNYLYLNNHDFTFTNIAQQAGLSEATFSHGAAYGDLDNDGDLDLVVNNMDLPASIYQNNSIQQQPGSHFLKVKLHGPEGNPFGLGARVIFRYDEVRQTIILQSSRGYLSSSEPVAHFGLSTEPKVKSIEVIWPDQTVQTVADFAIDQTLEIGYQPKEIPQTSVKKLFEESETTLFTHQDGTFNDFKQEPLLFKPQSRKGPHMTLGDLNGDGLEDVFVGGGSGQSGAILLQKKDGAFQRIEEKTLTLDLEPEDLGAALVDLDLDGDLDLYVVSGGSSFPKGNPTYQDRLYLNDGKGRFQKGTLPKISHSGTVVKVSDFDQDGDPDLFIGGGAVPGQYPSSEPSILLENRNGQLLRSTLLPAVEGIVNDALWWDYNEDGYDDLILAGEWMPITILKNQSGKSFENVTEKMGLSKSHGLWNSLVVLDLDGDEKNELMVGNLGLNHLFEVSSSEPITAYQSDFDQNDQKETIITHYLNGERWPLPRKETITGVLPHLKKKFINNQTYAEARLEDIFSSDQLAQATTYNLYELRSGYFTLREDSMIFSAFPTIAQSFPIYDMVFLDLNGDQVKDLLLGGNMSYSEVEQGPYDAGGGLILWGTERALTFDANNFQFLNWTGDIRKMSIQNVNGTQMLWVVQNNGPLKSYNLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTB9</accession>
    <name>A0A654DTB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="320" mass="34906" checksum="F7ABD6553C293FA1" modified="2020-04-22" version="1">MLKKVAIGVDIGGTLTKLGIVDREGNLYAHMDFSTTMHKGFGDYLDELKKQIEGLRSQIDFEHEVMGIGVGAPNANYYRGTIEHAANLLWKGIVPFTDELKTRYDLPIYITNDANAAAIGEMIYGNAADMKDFMVITLGTGLGSGIVSNGQLIYGYDSQAGELGHVKIVDNGRLTGLGIRGGLEAYVSSTGIKRTVFYLLSDMMDDSVLRDYSYNELHGEIITKAAEDGDPIAKAAFEMTGKILGEQLANFTAFSHPEAFFLLGGLAKAGKWIFDPTRKHLEENLLPFYKGKVKLLPSGMMKKNAAVLGAAALVWNHLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU01</accession>
    <name>A0A654DU01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="136" mass="15137" checksum="1F31050F648486D7" modified="2020-04-22" version="1">MKENLENKLEDRKIKPTTMRLLVLRKLVESGAAISLSDLDAKFEQADKATLYRTLKTFEDKKLIHSIDDGTGSVKYALCEEGCECEPQDQHIHFHCITCGETYCLTQSKIPQTVIPSGFKAASASMVYKGTCANCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU20</accession>
    <name>A0A654DU20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="271" mass="29858" checksum="E096AEED55111166" modified="2020-04-22" version="1">MSMITQPTLVRDHSLKLLSGSAKVWFLFAVAGQLIFVFHILHFYGGATIKGDLAVWNEILYHGIITGDTMGNVALGIHLLLAAIITLGGPIQLTPWVQKHMRRFHRRNGRVYVVTAIVISLSGLYMIFGRGAVGGPVMGAGNTLNALMIMVCAVMTMYFAMMGKLDVHRHWALRLYLVVSGVWFFRVGFGLWILIHQGAPGHTDTFDGPFDIFLAFGHTLIPVALLQLYFWVKEKGGPASRKTMTLGLVVLTALMAGGIFMATVIFWLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU38</accession>
    <name>A0A654DU38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnc</name>
        <name evidence="10" type="ORF">MARINOS108_10141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="179"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD10630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="248" mass="28647" checksum="495D3891A2FD5AB9" modified="2020-04-22" version="1">MPSIFRKSHGFIKYLFSGPDKELYRNYKIVTGRRPNNLSLYERATRHSSAAELNSKGLKDSYERLEYLGDAILGMVVAEMLFKRFPFKEEGFLTELRSKIVNRESLNNLSKKIGLKGLVKYHKNKGSSISHKSVYGDSLEALIGAIYIDQGFRFSKKFIENKLIQPHFDFEELASTTTNYKSKIIEWSQRENKTIRFEILKSNEDARDRQFVAQVIVDEEPLGKGFGFSKKKAEQDAAQRSLQQLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU53</accession>
    <name>A0A654DU53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025018284" evidence="2">
        <location>
            <begin position="31"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="65"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="399" mass="44522" checksum="F2882977F685B405" modified="2020-04-22" version="1">MKNIKFNHLIYIAWALLTPLLISCSSPVNETEDEEHDEGNIVELTQAQYDLADIQLGKIEQRTIGSELRVSGIIDVPPQSNVSINLPYGGFVKYTEMLPGTRVKKGQFLVSVENPQFIQFQQEYLEGLANREYLKADFERQSSLYDEKVASGKSFQQAKSAYLSNEARIKSMEARLKLIGFDLQKVQAGEISSSVRIYSPENGSVREVFTNVGKYVGPQDAIMNITNSEDLHVELSVFEDDIPLVAKGQRIRFSLANNLNTWREAQVFLVGSGVREDRTVTVHGHLKEESADLLPGMYVSARIETGTHAVWAAPDEAIVRFGGRHYVFTFLEKKMENGEPHYAYEMIEVNKGISEDGFSEVSLADPTLDLSTIDLVTQGAFTLLAKGKNSEEDGHGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU59</accession>
    <name>A0A654DU59_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpC</name>
        <name evidence="10" type="ORF">MARINOS108_10253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD10837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="265" mass="29374" checksum="0A23252FD20F5C0E" modified="2020-04-22" version="1">MNILDQIVADKKEEVAQKKSLYPVKLLEQSTYFGAQPVSLRKYIRRPDKVGIIAEFKRKSPSKGVINDGAKVERTSIGYMQAGASGLSILTDTKYFGGKNEDLTIARSFNFCPILRKDFIIDEYQIIEAKSIGADVILLIAACLKPEEVKSLGAFAKSLGLEVLLEVHNEKELNDSINEHVDLLGVNNRNLGTFVTDVDTSRALAAKIPNDFVKVSESGINDPTVVVDLMSHGYEGFLIGEYFMQKGSPEKACSDFVKRIKELKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUA9</accession>
    <name>A0A654DUA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="457" mass="53490" checksum="7214F6BA8A37472B" modified="2020-04-22" version="1">MKRRNDNWQLELIVTAILLSVIFSADKYIFDKSTDIMYERYFPYTTLMGLAMIISFYLLKHSLVIHFVLRILWIAALSLYRSDQIDKANLTTSVPVSPSLLRYVRLLDYVASLIFPIMLNCIFITISLTLYVLYLSLLSDYFFLLMAFIFIGVFGFMEFLKPGFFSNAHVPDDLISKILLLTSKVLIRANSVLTLSILWEPLYRSFTKRVAKRTVGLLLVPYIIISGFLPPMSRFESNKFFPEFPDKLECNTEVYFDLIYYYDDYKEYHRSNPIAYPITTLSIPSRKLFDDFLEVFVRYTDSDDYLLEKNTNLIPVRKSGLVNIFSWRKDIISQNPKLDSMQRVINENKKGEKPTDHLEKVLKAELRKIKEDNSNKIKEALISRLEFKIDDQLIPRDSIQYGYFNHPNDGERGLLCIIDLKGYKRGDHVLGFKKENFNFHSNKIDTICLKLPLILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUF9</accession>
    <name>A0A654DUF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RagB/SusD family nutrient uptake outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="258"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="494" mass="55205" checksum="9F6C1139303D962C" modified="2020-04-22" version="1">MRAFTRIFQIIILTAAVSGCADFLEEDMQGTYSNSTFYKTGDHAELALTGVYNITSFSNTNNNLWVFGDVASDDAVKGGLAGDQNDIQFIEEFTYQPSNSYLENLWRHYYEGITRANYLLGSLPGIEMDADRKEVIKGEALFLRSYFYFHLVNIYGDIPLKLKPPVTKDQVHVPLSTVSAIYAQLDSDLEVAATLLPVKNDVGRVSKGGALGLLAKIRLFQEDYEGALEAIADIEDLGIYELQAVYRDNFTLGNQDNKESLFEVQHLSGASPKLGSVLNQYFAPQAEGGYYFNSPTQDFVDDFEKTTAEVVDPRLDYSVGRAGQTWLNGEPFDPTWSSTGYIVKKHLQPLSEVPKGTKGDGGLNYVFMRYAEVLLMKAEALNESASPAQALVPLNAVRKRARESYLYDETLAGFGSVPAGLLPDVVTTDRSQVREAIRHERRVELGLEFHRYYDLMRYGKSVAEAALSDTDFNYESNRYFTIPLSETDINQSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP9</accession>
    <name>A0A654DUP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">MARINOS108_10726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="123" mass="13831" checksum="93171A98DB10EDC1" modified="2020-04-22" version="1">MILVDTSVWISFLRNSDPDLTAILKSYLKRKEIYAVSAVFGELLQGVKNKRERELVVTLWENLPAVDETDLFIHAGNLSNEHKFYAHGIGLIDCYILAAALRNDLGLWTLDKKLGEAADSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUQ5</accession>
    <name>A0A654DUQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_10059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD10453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="27182" checksum="AA62F4DC12C4EE52" modified="2020-04-22" version="1">MTLNCMIVDDDEMSRLLVSRFIEQTDFLNLTHVLDNTIEASNILVGEKNNDVDLVFLDVEMPEMTGLELSKSLKNTYPIIFITSKKEYAIEAFEDNVLDYLVKPIEYTRFLKSVIKAREEREKELKFAEMEDHIFVKSDSKLVRIPFENLFFVEALADYVIFNTLKGKFIVHHTMKGIEKRLPMSMFSRVHRSYIINRSKISNIEDFNISISDKVIPIGASYKDEFLSRVNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUV7</accession>
    <name>A0A654DUV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="141" mass="16081" checksum="9A931DCE494B4268" modified="2020-04-22" version="1">MASLTPFHLAVPVDDLNETRAFYRDTLGCPEGRSSDHWVDFDLFGHQFVIHLQPKRVSQEVHHNPVDGHDVPVPHFGVVLAMKDWEELAARLKSKGVVFVIEPYVRFQGEVGEQATMFFRDPSGNALEFKAFKDMNQIFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUY8</accession>
    <name>A0A654DUY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="409" mass="44728" checksum="19B5FDA28171C885" modified="2020-04-22" version="1">MMKEMKLWILGGGLGMLMLLGSCKDEDVTPKEEKVEASPQTLVEATRIFSRPAGDLRAFISLSGLDVDVNLMVHDVTLYKITYKTDYKGDSITASAVIMLPNTEDTVSTVSFQHGTIASEAEAPTNLELSDGQIIFASALASTGLVVILPDFIGFGASGDLMHPYYVEDLTATSVVNGIYASRQLVADLEMSIDDELYLAGYSQGGYATMATHKYVEEVGMAYYDLKASFPSSGGYDVKAFQEYFFTLDTYHQPFFLAYVAYAYKTTYDWNQELNVFFNEPYAAAIPGYFDGSKSGGEINALLSDELSILLNPQFIAGVDMPAYAFVKEAFLENSLTDWTPTIPMFMYHGDADITVPYQNSVDVYAKLIANGASANVVSFTTLSGGTHGTGVGPYIEHFASEIFRLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV31</accession>
    <name>A0A654DV31_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ORF">MARINOS108_10939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="305"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="385"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="541" mass="61025" checksum="6F9739E7D7D47D4A" modified="2020-04-22" version="1">MSKVKYIFVTGGVTSSLGKGIISASLGKLLQARGYSVTIQKFDPYINIDPGTLNPYEHGECYVTDDGAETDLDLGHYERFLNVSTSQNNNVTTGRIYDNVIQRERKGEFLGKTVQVVPHITDEIKNNIFKLGETGKYDIIITELGGCVGDIESLPFIEAVRQVRFELGPTNCISIHLTLVPYLKTAGELKTKPTQHSVKELLEAGIQPDILVCRSEYPLTPEIRKKLALFCNVPINSVIEALDAETIYDVPILMRKEKLDERVLAKFKHSYKREPKIDQWKEFLGRLKNPTSQVRIGLIGKYVELKDAYKSIAEAFVHSGAENECNIEIDWIHAEEVDEANAKKLFKNLDGILVAPGFGERGIEGKISTVKYARENKVPFFGICLGMQCAVIEFARNVLTLKQANSTEMDPKTKHPVIDLMEDQKNIKNMGGTMRLGAYDCNVKKGTKAYNVYGHTKISERHRHRYEFNNQYLEQFENAGMIASGKNPDTNLVEIMELKDHPWFIGSQYHPELKSTVANPHPLFVKFIKAAIAHRKEKESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVA2</accession>
    <name>A0A654DVA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="111" mass="12651" checksum="963B16EF06EE2C0A" modified="2020-04-22" version="1">MLIAMKDKTKKTIVSEELMSDIFNGSIALIGVCLIVLTLFQVTDKSALYWVDEFFYLTAGCYLLTSISAYLSLRKPGQHRLRPLTDWLFLFSLCSTLLSICVLIYEFQTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVK6</accession>
    <name>A0A654DVK6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">gyrA</name>
        <name evidence="12" type="ORF">MARINOS108_10679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="11">
        <location>
            <begin position="24"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="538"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="850" mass="95288" checksum="8F5A341F75D790A7" modified="2020-04-22" version="1">MSDDSENLPEGESGTYPGQNIIPINIEDEMRGAYIDYSMSVIISRALPDVRDGLKPVHRRILYGMLELGVNYNKPYKKSARIVGEVLGKYHPHGDTAVYDTMVRMAQPWSLRYQLVDGQGNFGSVDGDSPAAMRYTEARLKRIAEEMLADINKNTVDFSPNFDDSLKEPSVLPAKLPNLLLNGASGIAVGMATNMAPHNLSEVVDGAVAYIDNNDITIEELTQHIKAPDFPTGGIIYGYQGVRTAFETGRGRVVMRAKAEVETMKSGREQIVVTEIPYMVNKASMIEKTAMLINEKKIDGISDIRDESDRDGMRIVYELKKDTIPNIVLNNLYKQTQLQSSFSVNNVALVGGRPKTLNVKDLLKYYVEHRHEVVIRRTQYELEEAEKRAHILEGYLIALDNLDEVIKLIRSSRDPEIAKLGLMENFKLSEIQARAILDMRLQRLTGLEREKIIKEYEEVKALIEELKAILADEGKRMEIIKTELLEVKDRYGDERRTYIEHAADEFTAEDMIPDDEMVLTISREGYIKRTPLIEYRTQNRGGVGSKAATFKSDDFTEHLFVATNHNYLLIFTEFGKVYWHKVWAIPEGSKTAKGRAIQNLINIDPADKVRAVINVLNLDDPDYINNNFLIMCTENGTIKKTTLEAYSRPRQNGINAITINEGDKLLNVRLTNGDNHIVIASNTGRAINFHESDVRPMGRMAAGVRGIKMKEGEFVVGMVCVDHKEPADLLVVSENGYGKRSDLSDYRITKRGGKGVKTMNITEKTGALVAIKDVEETDHLMIINRSGIAIRTEVSSLRVMGRATQGVRLIRLNDDDSISAVEKISNIEGDDEPEGGEEGATQSPNEENVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVM2</accession>
    <name>A0A654DVM2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="319"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="461" mass="51831" checksum="9A39C9F5E1A16BB0" modified="2020-04-22" version="1">MIKLNNWAQLSVVLLLWACAPQPEKVTTTISGEIINPIGDVITFRLGGDRITDTLDADNKFSTTFDITTPVDIVFGHGGEITYLYLRPGDQLYLTLDPAEFDESLTYSGKGAEINNYKAAMVLLGDSLLSTRDLYKMPEDQFLVALDSVSAIELGYMADFNIDDAAFIAYTRENSKWSDIVTKMRYESAHRSLLDLDSFSVSDTYYDFQLALDVNDTSLLKYPAFRSYVDESIEKEASRGYYARADESEDYSGFYVEAINALIQVPSLKEQLMYEFVSDSYSYFPVEVRDEIVAAWKGLNPDPERVDEIDQMIAEFQKLEPGNPAPDFRYVSIDGDTLTMADFKGKLVYIDVWATWCGPCIAEHPHMEKLQQRFEGQDVAFVAVSTDSSPDPWRKMVNERKLGGIHLYAPGAWQSTIITDYLIQGIPRFILIDREGNIIDANAARPSGDIGDQLEALLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVQ4</accession>
    <name>A0A654DVQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="334" mass="37284" checksum="DAB4A690FB06C223" modified="2020-04-22" version="1">MNVAEQKRILIPNSDVEISPITYGAFAIGGWFWGGASKSDGIEAIETAIDLGITSIDTAPIYGMGRSEAIVGEAIRHQRGNVQILTKFGMRWDLEKGDFFIDSQDNDGNPVKIYKYNGKESIIEECEASLRRLNTDYIDLYQMHWPESVTPIDEVLEALSELKKSGKIRAAGLCNSNIELLRADSDGILSTNQVAYSMLNRSIEKELVPYCVETEIGILSHTILHKGLLTGKIRPGHQFGEGDHRAKNPMFKPDNHQKIVTFLDSLNPIARKWDCTLSQLVINWTMQQPGITSVLVGARDKHQMKDNAQALNFMLDEADLLIINSLLNDLILEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW52</accession>
    <name>A0A654DW52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein ZapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="34819" checksum="A097010EB5862978" modified="2020-04-22" version="1">MEVQNENSTPQSNPKPKDRTALFIGLIVALLGVLIFLYYTNDTLEKEKEAQALELNKTLLQLDSISSQLDSKILTISQLGGEIDTLLKIKQQLETEKKQLLTNQSRQKDLMASLKDRVDGYQELLLAKDVEIEELKKLNEELLTENVELKTEKQQLNESIQEINKAKEELADKVAFASRLKVEGLKVFAVSDGGKEREGEFRSRQVDQLKITFTVADNKVAPIEGKDLLVRIIAPDGNVLFDVTRGSGSFIFEGRELFYSAKQEILYDKNSQLVTVFYKKGSEYATGSYQVEVYTDDYLMGKGSFLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWK4</accession>
    <name>A0A654DWK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_10757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="298" mass="32247" checksum="C565E26C2147ED15" modified="2020-04-22" version="1">MPVTTLIIIGAVLAGFWFFTFIFPISLWISAIFSGVQVNLLDLVFMRFRKVPPALIVKSLILATKAGIKDVDTAKLETHFLAHGNLMKVIKALIVADKANLNMNFQQATAIDLAGRDVLEAVQVSVTPYIIVVPAITGVSVDGIQLIAEARVTVRTNLQQLVGGAGEETIQARVGQGIISRIGEATNYMEVLEKPEEISKRVLANGLDAGTAFEILSIDIADINIGRNIGAILQIDQAQADLVIANAKAEERRAMAVALEHEMLAKIQEARALVIEAESEIPSALSEAYRKGNFYQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWS0</accession>
    <name>A0A654DWS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="10006" checksum="687F659C0EC28A63" modified="2020-04-22" version="1">MKTFAQFIRKGLSQVENTIHQYYITLHFTPHQYHNNGIQKMPLEGNNGFFTLFLFIFIFIDNTTCSRSTVYLRIKPPFTTHIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWY3</accession>
    <name>A0A654DWY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="105" mass="11473" checksum="8D6A4DD8B0AA44D5" modified="2020-04-22" version="1">MLQDDHAVLKGKRAALQDGRAVLQDNRAGFRDNRAVIQEGRAVLEDNRAVLEDKRAALQDGCAGGRTVQDARIANNGLFEIGNLLHLIALQASNSHWWLLVGCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX42</accession>
    <name>A0A654DX42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="155" mass="17701" checksum="4EAD8CC0F97C1B69" modified="2020-04-22" version="1">MNLLLPKTFFFVAILFVTLEASGQNYKPQVKTDHIAIVVADLPASAQFYSEILGLNEITNQTKKPNIRWFTFADGVELHLINRSKEGIQLIKDVHLALAVNDFDAFVNMLREKKVNFENWPGEANSTNSRPDGVKQVYIQDPDGYWIEINDAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX85</accession>
    <name>A0A654DX85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="14419" checksum="F60881DEEAA00EC8" modified="2020-04-22" version="1">MKKIFVQGLVAGALSSLAGVVYFNIYQSTLLTQFDRIINTGSIIGTSFIGSMLIALGYLALYKFNKPNFQGWLNVLICLLSFVSIISPVGMALPLDIEFPELFPGLVVPMHFFPALAYFTIQPFFEVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX89</accession>
    <name>A0A654DX89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protease-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="117"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="362"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="577" mass="63226" checksum="5A43494E64CFF21D" modified="2020-04-22" version="1">MAFLRNLLATIVGLFIFCFLLIFLLGSIAASSESIPHVEDNSVLHLNLSGVVVEKAVDDPLQELLGGGPAPISLLDLLAAIDAAAYDDRIRGIYIEPQFLSAGYSSLQEIRDAIIDFKSSGKFVHAYGEYISEGDYYLVSVADSIYLNPQGSLEFNGLTAGVTFFKGLFDKLEIEPEIFRVGEYKSFVEPFIRKSMSEENRRQLTELITSVHDTYLQNVSATRGISVDALKEISDQMKVRLPEDAARVGLVSKVAYEDEMVDLLKSEVGLGSGEDLTLITFDKYMKTTSASSLSSNKIAVIVANGDIVMGEVDDAVGSDQFAKEIRKARESSSVKAIVLRVNSPGGSLTASDIIWREIMLTKGKKPIIASMSDVAASGGYFIAMPCDTIVAQPNTITGSIGIFGLLFNFGDFLENKLGITNESVSTGEFSDLMTVTRSLTEYERSIIQNQVEEGYRTFVTKAAQGRQMPVEELMKHAGGRVWSGTQAKERGLVDVLGSFDTAVKIAAEKAGIMGDYRLSFYPRQKPLLEKMLTDLSEAEVKIFAGQEKVFTPYLQQIESLQRMNGIQVRLPGNLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXI3</accession>
    <name>A0A654DXI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="766" mass="85541" checksum="23E648C051CE944D" modified="2020-04-22" version="1">MMNQEVKFKSISISNLNYCRMMKNLIFILLMLVLCEAKTQSISEDLEGKFMRFIENHPIETPVLQVGSRVVFTGDTLRISGMVTDLFFRPTDAISQVMKVSLVDTTGRTLRTLNFKNQAGTFYGSWYIPHTTPTGSYFLVAHSAYMQNFEEDLRAITPVYIKNIWDPGTTQKFTSIQAKRTFSVYPEGGKLIPGHNQKVLISAPQADATSGKIMSKSGKVISEFLFNEGFGVTFFTPDRKEDYFIQVSTLSGKTHRQAMDIERSGATFKVSKVGSRYFVNVLTTEASNQSLSMVLESGNRLQSILPVTFNDQGTATFVLPSSALQGHFHTAALLDEQWNVLAIRPFHTLPKTMTLSGPDTVKTDTQISYEFPAASGAASTFSMSIPDAFSSNTYLLTDMALHYAFAPISARVSAAGTLSIDDLLIYSTSWFDQKWNNILSESTPFSMTIPPELGIDLRGETETVLPEGSWVHFYQWKNKMSYSLEIMDGRFNLPLTDFHDQQTFTYAVKDSTGGPIKTQVKFENLSINLPEIEYIEEPATDSLINKAVGLKRVMAQYQSETLLNQPSLYDQLTADRVYDMTDYVILKSFQEVVVDILVGIGIRSVKGEKELRINDPVSGETFYYKPTIIINDHQVANDDMIWTIPPIYIDEIKVISSKEHLGVFEGLGVHGGILGIQLQDDAPDALIKNIIDQKIEVTGFLHSQKNPASDLPDFRHELINTAGKQNDWTVKSSDETGVYRALIQCLSTDGAVSIAEKKTVVILPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXK4</accession>
    <name>A0A654DXK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rnz</name>
        <name evidence="10" type="ORF">MARINOS108_11440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD13415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="272" mass="31120" checksum="4EFC52F162BEFB48" modified="2020-04-22" version="1">MIDCGEGTQLQVKRYKIKLSRINHILISHLHGDHYYGLMGLVSTLHLYGRTADLHIYGPPGLADIITLQLKYSATRLSYDIKFHEWVPETSSVIYEDDKLTITTIPLNHRIHCSGYLFKEKPKKRGINKLVVDKKLAPNQANALRNGEDIYNEDGSLLYKNSLATLPPKKPYSYAYCSDTKLIPQLVDVIRDVDLIYHEATFMDDMKDRAENTYHTTARQAAQLASEAHVGQLLLGHFSTRYRDLNPLLSEARSVFRESYLAEEGKRFVVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXT8</accession>
    <name>A0A654DXT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SusE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025970">
        <property type="entry name" value="SusE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14292">
        <property type="entry name" value="SusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SusE" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="361" mass="39644" checksum="8CF079515EA46B6D" modified="2020-04-22" version="1">MKKLLMCGAMIGGLALFSCEEEGEKVIIEEKDPIAAEISTPTAGFADVATANNLEEVLTFTWSEAQFNFPSEISYKVQIDLAAGDFSLPATLGTTSETTFSITYGDLNSIILSTLESPANEPIALQTRVIASAASKEDLVSAVVSFTFTAYEEEEQPQEYAKLWIAGDFQGWNIDAAATIASVKDDGVYEGYIFIPAGGTNEFKLYAQPGWEPQSYGTLNDGVIFEANYAGDNFIAPSDGYYFFSVDLNNLTYLLIKTDWGIIGAATPGGWDFDTELTFDMDTEVWSVTADMIAEGSFKFRANKEWVLDFGIDTDGNLAYANHPWLDYVEQPQLTVPEDGNYTITLDLHEAGNYTFDIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYW6</accession>
    <name>A0A654DYW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted metal-dependent hydrolase, TIM-barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="119"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="356" mass="40430" checksum="80AFCEB64E49A4EA" modified="2020-04-22" version="1">MGRAAWIIFWTMISGQLLAQSPDSLLLKDYQPRSIFNIPESKVTRARFPVIDMHSHPYALTAADLQRWIISMDSAGIEQTMILTYATGAEFDSLQEVYGAFGERFQLWCGFDYTGYNEPGWTEKAIKELERCHNLGAIGVGELGDKGLGLTYSHPTPAYGMHINDPRMQPLLKRCGELGMPVNIHVAEPAWMYEPMDATNDGLMNGFKWRIDQQQEGILLHEALIQTLAEALRANPGTTFIACHFANCSADLSVLGSLLDRFPNLYADISARYGETATIPRTMASFYTQYQDRLLFGTDMGSEPEMYEIAFRILETEDEHFYQPAYFNYHWPLYGFGLSDSILKKLYYENAQKILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYY6</accession>
    <name>A0A654DYY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_11921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023996">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023997">
        <property type="entry name" value="TonB-dep_OMP_SusC/RagA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04056">
        <property type="entry name" value="OMP_RagA_SusC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04057">
        <property type="entry name" value="SusC_RagA_signa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="390"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD14386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="982" mass="109601" checksum="8878E7BC91B37F70" modified="2020-04-22" version="1">MKSHSRQHSILFVYLFLAVFVTCPITKVMAQSSGEIIIKGKVTDETNNSIPGVSVYVKGTQTGTITDIDGGYALSGPSEGILVFSSIGFETVEVSANNRSVIDIQMSVSTQALDEIVVIGYGTTTKKEITGAVTTVKSEDFNRGGFNDPMGLIQGKVAGLTITKPNGADPMSGYQILLRGVSTLTSGQGPLIIIDGVIGADLKNINFQDVESFDVLKDGSAAAIYGTRGTNGVIIITTKAAKKGQQVLEYSGQVSVQVAPRGVRNLSAKEFKHAIETYQPSKTGSLFGSETDWFDEITNDLPVSYQHNISLSGGSESFSHRTSLTHSTDQGLLRDNLSERILLKTNIKQKVFDDRLLLDFNFTNNLRKYSPANYDLFSQAFIQNPTQPVYDDSDPATGGYSFKQGLGYYNPVAMLNERTREGQTNDIVLNLRATLEITDDLSWSNFISTQKSEWEENSYKTKYYPTILGINGEAEISNGRNSNTLYESMFNYQKEVNDHDFQVVAGYTFQEFEMNSSYVGNYNFDTDVFLHNNISAGSFFREGKSEMGSYQESSRLIALFGRLMYNYDEKYLASISLRREGSSKFGDNNKWGLFPAVSLGWRLSEESLFKDISWINDLKLRLGYGVTGNQDFSPYRSLILLERVGSLFYNQEWINSYGPGQNPNPDLKWEKKQELNVGVDFSVFERRLSGSVEYYLRKTSDLLWEFQVPVPPYLYPYLFTNVGTISNRGVELTLNAMLMKRGNFGWSSTFTASHNKNFLDKISNSEFTQSTYETAFLGGTIGVWSQRIKEGEELGTFYGPVWLGVDEHGNDIFKNQNPVGEVDKSKWEKIGSANPIAVLGWSNALTYKNWNLNLAFRGGIGGKVLNSNRLYYESWTAIGLRNIVHTQLENPEFIRNVTYSSKYIEDASFLKLDNVTLQYGFDLNSKYISRLSVSGSAQNVFWISGYKGIDPEVNLGGLEPGIDRLSYYPRTTTLTLGVNATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ28</accession>
    <name>A0A654DZ28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="124" mass="14471" checksum="28F86D1E4B278FD9" modified="2020-04-22" version="1">MKEPIKELTRAEEEIMQVLWQLESAFVKEIIEHLPEPKPAYNTVSTIVRILQQKGFVGHEAHGKSHKYSPLITKETYTKTFMKGFVKKYFSGSYKQMVSFFTQEENLSVNELEQLLDQLKKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ60</accession>
    <name>A0A654DZ60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Por secretion system C-terminal sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="1">
        <location>
            <begin position="905"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128870" checksum="5D9727A03312AB97" modified="2020-04-22" version="1">MISHFSAGTKTVVFSLLVALVFPEILHAQQIVINEVMASNTTLRDEDGDTPDWLELFNAGTTAVDLMGFGLSDQKEKAWIFDNVSIAAGGYQLIFASDKDRKTPPLYWETLIDQGDTWKYIVPQAPIADWTAASFDDSNWLSGPSGFGYGDNDDNTVLSQASSVFLRKTFQIGNLADLEQVILHMDYDDGFIAYLNGTEIARSNLASSDFDAFASPDHEAQLYSGGSPEAFDLSDFSSILTAGENVLCVQVHNVNATSSDLTAIPFLSVGKKSPSEVGLSAFLTAPSNSLHTDFKISADGETIYLFGADGTVVDSLVTGPMRSNISIGHPAGDLETLSYFTEPTPGTPNSTQGYQYFSEEVSFSKKGGVFSNGFQLTLSSAGSSENIYYTTTGADPTLDNAILYSSPITIEQTTVVKAVVIKENSIPVNVSANTYLFNANHSLPVISVSTDPYHLWDEQEGIYVMGPNADPNNPHYGANFWQDWEKPIHIELYEPNGTQAFSMAAGVKIFGAWSRASAQKSLAIFARKSYGAASIDYQVFPDHSMDHFNSLVLRNSGNDWNSSMFRDGFMTSLFHETVDHQAFRPAVLYLNGEYWGIQNIREKVNEDFLANHHHLDPDDIIILEANGASVEGDPASYWELINYIENNDLTKDEHYEYVQNHMDVFNFAQYQIGNIFIDNTDWPGNNIKFWKENKPGAKWRWITYDTDFGFGVYGAENYYNNTLSFAMDPNGPGWPNPAWSTFLLRNLLKNENFKTLFINSFADQLNTALSSRETLAKINALSDEIATEIANHMSRWGGNYNNWLYQVSVMKTFAEKRPQYMRQHIRSQFGLSGEHTLTVNSSNLNHGAVQVNALVIDEQDWKGIYFQGVPVRLSAFSNGGKFVRWEGDVTGTQSEIFLDLTQDMNITAIFESGSGNDIVINEINYKSGENLDTEDWVELHNPNNAAMDLTGWVFRDGDDENSFKIPDGTVIGAGGYLVIAKDLGAYGSFHSTASNVLGELEFGFSSDGECLRLFDATGKSIDEVCYLSSAPWPTSPAGDGFSLALDNPLLDNSKPESWYAHPNGGTPGYANREVTLSVPSPSTTVICYPNPASDHVSFSFQAHHQMVTLSILDLSGKMLTSESIHLRQTGLVTFEWQVPNTFQSGVYLIEITTQQGVQHGKLLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ71</accession>
    <name>A0A654DZ71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="54" mass="5539" checksum="8942AE6D40529680" modified="2020-04-22" version="1">MLKTVIPAQAGISSGQEFSGSLSGIVLLFDGAQSDNAQLRATISELGITMQKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ79</accession>
    <name>A0A654DZ79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="239" mass="27044" checksum="2C31472C44BC17E6" modified="2020-04-22" version="1">MKNLIIAISLLLQFLPSAYSQQIGVGVGGVLLLEYSKEYDSDTRGGQVNSTSKKQFDTYKIPTVSFFSFKESGHFFLFETGKFSIGSKDTETTHTNDVGDSQVIGGENTFNFTSSFRTGYSFRVSDNEKISTYLGVGINPQFDREVVEPRISAFKTAETILDTDLEILANLFIKVNPNIAINLAVPVKIWNYKFVGQRTDNPQMPQREQYQRNDSNEFLPLQFEFKAGLVYRFEKSKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR1</accession>
    <name>A0A654DZR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lactam utilization protein LamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="233" mass="25859" checksum="67D0623C575C927B" modified="2020-04-22" version="1">MKTWTINSDMGENIGNDHLLMPFLNECCIACGGHVGDESSMQKTVDLALKHGVSIGAHPSFPDQVNFGRIPMRMEKNALSDTLRTQIDALRKIYPDIEHIKPHGALYNMAAVDPEIAWTVLEVIKDYPGTMLMAPWKSTIAQMAEEQGIKVRFEGYGDRRYHSNMALVSRKNPAGVISKANDAVEQVKSISDRGIFISIEGDEIEFVAETFCVHGDNPDALKILQALHHLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZZ8</accession>
    <name>A0A654DZZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ORF">MARINOS108_110110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="187"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="7"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VXD15953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="359" mass="39019" checksum="4427E844376B69DB" modified="2020-04-22" version="1">MISGGGTGGHIYPAISIAQALQDMVQDVEILFVGAQGKMEMKKVPEAGFQIVGLWISGIQRSLSAQNLMFPFKVISSLFKAFGLIRSFKPHAVIGVGGYASGPLLYAASAKKVPTLIQEQNSYAGLTNKWLAGRVNKICVAHDGMEKYFPADKLVVTGNPVRKTILLKPDLKPSAYEFFGFDSSKKTILIVGGSLGARSINEFILAGYDRLAASGYQVIWQTGGYYFEEMKRRVTNPSANILLKDFVREMQYAYAVADVVISRAGALSIAELMLTGKPSILVPSPNVAEDHQTINAMALVERDAAVLVKDNEAAEKLIDTAFALIEDEDRKRVLSENIKGMSHPNSAKDIANEILKMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E066</accession>
    <name>A0A654E066_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialate O-acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_dom4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BetaGal_dom4_5" evidence="1">
        <location>
            <begin position="37"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="BetaGal_dom4_5" evidence="1">
        <location>
            <begin position="188"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="330" mass="38443" checksum="E7F689D7CA1A1080" modified="2020-04-22" version="1">MKSFITLLIFILPLVGISDDLRRVVDLRGEWRFSIGDNPRWANPDFDDHNWEKIFVPSAWENEGFSGFDGYAWYRITIDLRGLSENNLYLVLGYIDDVDQVFLNGEMIGFSGSFPPRFYTAYQSFRRYRIPPELLNKDGKNVIAVRVYDTVLDGGIIKGDVGIYTNRNEPEKTLLLEGLWRFQEGDNERWKENDYDISDWEYMMVPSFWKSMKYSRLEGVIWYKKEFVLPPQLQEESMLMLVLGKIDDFDHTYLNGVLIGSTNDGKPLGYSNSWHQYRVYPIPNELLNRKGKNIISVRVKDIGGNAGIYEGPLGIVPFSNYRQLLNARDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E090</accession>
    <name>A0A654E090_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="480"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="551"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="839" mass="92650" checksum="1B7C878D22A77A9C" modified="2020-04-22" version="1">MNFNLTIRRKMMIFIVGVTVLVYIISLGYISFQLRANAIDEAQKLADSYAQQKANEIKAILDEDMAVARSMADIIKDYTFMKRPLRDTLRKNLMVNILKQYPKYDATWMSWQLWAIEDGYDKPYGRERKNYYMRDGKLNSSGELANLDGDPTSGVYWFLKYNRDHSEKLSEPYWYLDYDYSSGATDSLLGISPTVSIEVDGKFVGVIGTDMTVDDFKGVTEVDYYDNGFAFLLSNQGVIISHKNESLFSQSMDTLSIVKKSPYNVRERIKNGDSFSYQVYDEDQGEQVYVSFAAIPIGRSSFPWSTGFVVPVSEITAQFNAVFMVTLIVGLAGLIVLVIITYKISAAIAQSLEKSSFLLTKLAEGDLSAENRLNIQSRDELGVLAAAANELMDDLIRKAEFSHLIGKGNLDTEFASSGKNDMLGISLLRMRENLRTVSRETREVIQNAGENGELMTARMKTDWEDGAWKELSDSVNNLLDSISLPFNKINTMVDAMAAGDLTVRYDEEARGDVQVMASSFNKALDNINELIENIAGMATIVNESSVEMRTVSEEMTYNTREIASSISEMSNGAQNQVVKVDESSGLVEGILRSSNEMGEQAENINEAAQGGVENSEKGQSLVKKVGFSMRDIAAFSSDTHDSIQVLTRRSNEISRALGVITEIASQTNLLALNAAIEAAQAGDAGRGFAVVAEEIRKLAEDSKKSAREIEQLVNDVQSDVSTAATAIEMMKASVKSGEDATNFASEAFNEITSSSNHTLLMSEEIRKRVKQQIESIKNVVTITESVVVIAEETAAGTEQIASSATELSAGMESYVQKSQSLSDVAAELIERVSKFRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E098</accession>
    <name>A0A654E098_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="42" mass="4255" checksum="29020671996D7FA2" modified="2020-04-22" version="1">MSDASTELSMTFSIDVALGIVTLSPVLLSDLGIVISSSALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A9</accession>
    <name>A0A654E0A9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018673">
        <property type="entry name" value="DUF2141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09912">
        <property type="entry name" value="DUF2141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="132" mass="14656" checksum="5B455D580803E396" modified="2020-04-22" version="1">MINILLIVLLLLTPNEVKLEISGIKKPIGNLLIAAYNTRENYLDESQMTQGYVIQVRESGTLTFMIDLPEGEYALAVMHDVNEDGKLNKNFFGIPTERYGFSNNARGTFGPPSFDDAKVFLGSGDTLRIALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0C3</accession>
    <name>A0A654E0C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="196" mass="23137" checksum="C2957670B2F4BEE1" modified="2020-04-22" version="1">MMTFFDQVYQKLFSKPETANEVLVYEPISRNEHYSESYAFWLHSVNHKRLIRQVAESYLLKQNNLVGEPDVHLLSTNLSNGFAISFNEEIDKKEFQFFFDWLGEKVEALPYKRSNSDVTITDKGNVIESKEKHYFKPIQQSQEAPLDQQFGNILIEHISIDNRPSFIKLVANTYNDRMYKNPDSFEFLAKYLFEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E120</accession>
    <name>A0A654E120_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartokinase</fullName>
            <ecNumber evidence="3">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_120310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="416" mass="47712" checksum="680DB5D966AE529B" modified="2020-04-22" version="1">MRIFKFGGASVRDGQGVKNLVEIVKKYMDRPLVVVVSAMGKSTNQLENIARQAFAGESYEEGLREFISSHQSLSQELFGTVPDDVNNWLIQLERSLENRTASWGQFYDSVIPYGELLSTSIVYHQLQSQMECSWTDARKYVKTNSIFTEANVEWQLTEHFIEREIPELLKKGPVITQGFIGSDLTGKSTTLGREGSDYTGAIFAYCLKAESLTVWKDVPGLLNADPKRFPSAELFDELSFQEVTELTYYGAKVIHPKTIRPLAQRNIPLFVRSFLEPSGKGTRISEQEKTTTKHCFVFKENQLLVTLRVKDNSFMDEKKLVKIFQAMDHANIKINLMHSSALTFTFCMDYQKDKLDGLRDFLQRDFQLLYNEGLQLATIKNYQEGSFSFLPETTEVILEQKTRNNYQVLYRPIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E156</accession>
    <name>A0A654E156_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_140133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025016893" description="CHAT domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="688"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD17652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1344" mass="151109" checksum="D114DF44F4062398" modified="2020-04-22" version="1">MKRLSLGLIFFLTTSLCFAQDWAASYQQSVDFYNNYQSAEARLAAERALEQIKSTETKASKNQTVILRQLSIICYDLGEDAAALSYAKEEVEVLIALGENRDMNYANALQNLAVIRMARSEYGAADPLLSEALDLTLEYNSEDSYEVAAAKGNLAIAKFQLKEDEAARTLFESSQRVMNTYEEVGPEYFNIIYNYGSLLSENGEYEKALALFVELVDYYNEGTPSFEYGSMLIKVGDALDQLGRFSEAVSQYELAIENFTDLGEQNSEEYSIALNNLTIDLQKTGQFGRATELIEELVLQKEAEQETNPASYASTLTNYSNLLIRNGELATAKEKLELVMELYTSRLPGDLTYVNALESLSGLLLTDGDITGATQKIDLALEVAREKGMKSRLYALYNQKAKILTSEAKYTEARNIAEEALQESITLFGSDALQTAFVKNTLAGVYTQLGAYQQAGKLYLEVLPIFRQTYGESHPEYATVAANYSSLLQLEGSYYTAEYYLKIAEEIKRQAYGKENRDYLTTYENLGLLYLNTARYTEAGQVLSEIKAIKEKILPTRDPSLAYTLANLGTVKKQLAEYGDAEKYLKEARSIYETSYGTQHIFYASVINNLALLYQKMGNLDAAKPLFEQSLETYQTQIGKMNPEYATALENLATLYQMEEDYDRAKALLEEVLVIDEAILGTNHPLYSKTLHNLASIYKENQEYDQAKTLYQKALDIDEKVFGTNHPSYASTLYNLATLEQELEHYDQALTYYQQVVDIRLSILGPNHPDYAYSLYGLASIKHKTGDFEGARPLYLRVTERYLDFINQYFPALSESEKSAFYGKIKPVFDSYLDYAVEFCLLNKGTQSDQDTLIGSMYNLQLSTKALLLNATNKVRNTILSSGDTDLISLFNDWVGLKENIVKAYSMSKEELELSNIKIADMEAESNEKEKQLSLKSSSFAGAFETEAPTWKRIQEQLSSDEAAIEMIRIKKKMKQDSVLYIGLILRSDEGAIPELVVSANGLQMEDKGFKTYKNSIIYKILDERSYATFWKPFDDKIDTSVKRVFLSADGVINKVNIATLYNPEKKEYLIDRYKVRLLSNTRELLEMTSPEGTKNDAVMFGFPKYYISSQAKNNSGGLLSPKDMERSFGSTISELPGTLKEIEEIGQIVETSSWTFESFLAEAATEDQIKKISSPKILHIATHGFFLEDIKVDDEAGGLTSRNAKFNPLLRSGLLLAGAQNTVKNEDLPGEEDGILTAYEVMNLNLDNTQLVVMSACETGLGEVKNGEGVYGLQRSFIVAGADNLVMSLWKVNDQTTQLLMSAFYRNWFGGQTKLEAFNAAIAEVRKEFKEPYYWGAFVMLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1A7</accession>
    <name>A0A654E1A7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_140136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="160" mass="18235" checksum="C851D01954FD0D59" modified="2020-04-22" version="1">MIAIDEMPDHARIWVYQADRPFSEEERVLIDRSFEAFTGQWAAHGNKLMATYGIQHNQFIVLAVDESYNQASGCSIDASVQVIRQIEQHTGLSLLDRTKVAFLEEGKVKIKPFNQLKAAVEAGEIRKETTVFNNTVQNASEWRTQWAVPAQASWLSRYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E3</accession>
    <name>A0A654E1E3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="203" mass="23539" checksum="50801AA7BA92DF6D" modified="2020-04-22" version="1">MELFKDLIDPKRNLLPHDGTVNYYGKVIPEPDHYLHQLLHHIEWRPDEAVIFGKHITTKRKVAWYGDRPFDYTYSNTTKQALPWTEELLALKQIIENATHETFNSCLLNLYHSGEEGMAWHSDGEKDLKRNGAIGSISLGAERKFSFKHKVTKQRVDVNLEHGSLLVMTGTTQTHWLHRLPPTKKVSTPRVNLTFRTIMNQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1G2</accession>
    <name>A0A654E1G2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="50" mass="5834" checksum="16F6123CF280E5B0" modified="2020-04-22" version="1">MNDRLFIHTLNYGVGKKGNVFLVYAFEPHPNRNAPRLFQIRIKTNNIAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N2</accession>
    <name>A0A654E1N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulatory protein ZraR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zraR</name>
        <name evidence="4" type="ORF">MARINOS108_120198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="139"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD16422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="385" mass="43133" checksum="3B0A4C70747A8238" modified="2020-04-22" version="1">MSHILIVDDEKTIRQALKDILEDESYEVSEAPDGEAAWALLEEQTFDAVLCDIKMPKMDGVELLSKAMESGMDVPFIMISAHGTIETAVDATKKGAFDFIQKPPDLNRLLLTVRNALSNSTLQTETKRLKKKINSRYDIVGESAGIVEIKETIEKVAPTEARVLITGENGTGKELVARWLHEKSHRSASPMIEVNCAAIPSELIESELFGHEKGSFTSAHKQRSGKFEQAQGGTLFLDEIGDMSLSAQAKVLRALQENQITRVGGDKNIKVDVRVLAATNKDLRKEIEAGRFREDLYHRLSVMIIHVPALRDRSDDIPLLVDHFLNQVSQEYGTAPKKITSEAIELLQKYKWTGNIRELRNIVERLIIMSNAQITKEDVIKYVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E203</accession>
    <name>A0A654E203_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_140047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025010729" evidence="1">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="213" mass="23385" checksum="A32C162BBA6A6774" modified="2020-04-22" version="1">MTENMKRTFLLVTGLLVTVAVLFVSATDTPEDGYGVGDYASDFKLKNVDGAMVSLADYKSAKGFVVVFTCNTCPYAKLYEQRIIQLDQKYASKGFPVIAINPNDVSKQPEDSMEEMMARSKEKGYSFPYLRDDSQAVASAFGASKTPHVYVLNKEADGKFKVEYIGAIDDSPREASDVKQKYVEAAIDALLAGKKPAITTQRAIGCTIKWKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E210</accession>
    <name>A0A654E210_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="189" mass="21953" checksum="7F6A2FB8CB0282CE" modified="2020-04-22" version="1">MDKKRCRWAEGTFDEYIRYHDEEWGVPNHDDAIHFEFLVLESAQAGLSWSTILKRREGYRKAFANFEVHKVAAFDSKKINELVENTDIIRNRAKIEAAVNNAQRFLEVQQEFGSFDKYIWGFVGHQVKIGRWEEKGSIPATTSESDLLAKDLKKRGFKFLGSTTIYAHMQAVGLINDHTVDCFRFKELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E249</accession>
    <name>A0A654E249_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD10575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="145" mass="16764" checksum="148E64F343813752" modified="2020-04-22" version="1">MKTSHNPETLVLTFFERVWHAPHELEAIDELMTEDYIIYTAGTAVAGRERFKDWIRGFQTLLLDARTDSEDIFYNEAQNKVVSRWICSGRNNGIFGLPADGREVSFSGIAIWEVRNGRLARCWAERSAYELYQQLITTDRPGQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E265</accession>
    <name>A0A654E265_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">aroK</name>
        <name evidence="3" type="ORF">MARINOS108_20011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD17983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="164" mass="18468" checksum="608DC58BCE03F160" modified="2020-04-22" version="1">MKLGKIYLIGMPGSGKSYFGKQLASSVEFPFVDLDHEIELQEGKEISAIFSEKGEAHFRKVESKMLVSLSEKYPGAIISTGGGTPCFHKGMEYMKDHGITIFLEADRELLIERIARKDHRPLMQGDVENRVDELLKARLPIYRSAHISIEHRDIDLLLAAIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2A4</accession>
    <name>A0A654E2A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gliding motility-associated protein GldE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MARINOS108_20273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019862">
        <property type="entry name" value="Motility-assoc_prot_GldE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03520">
        <property type="entry name" value="GldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="453" mass="51041" checksum="44A9454C271A2E01" modified="2020-04-22" version="1">METALDDPYPSALFLAITQLPVSFFLINGIGILLLLLLSGLISGSEVAFFSLSHDQIQDAKTSGNKNDKYISSLVLDPKRLLATILILNNLANIFIVTISTFATWKVVGSKDAGGIVIVVLTVSITVMIIFFGEIVPKVYANHNNLSFARMTAPMLTFADKILRPISWFLMALSNIIESRIQKKGYNLSVDQINQALEITADKEVSDEEKGILKGIVNFSTLSVRQIMKSRIDITALDVDTDFHDLMDKVNKTGYSRIPVYAETVDKIEGILYIKDLLPHLDKKEEFKWQTLLRPGFFVPESKKIDDLFRDFQEKQVHMAIIVDEYGGTSGLITLEDVIEEIVGEINDEFDEENEIAYNKLDANTYIFEGKTSLNDFCKITGVDSDVFEKVKRESESLGGLLLELNTKLPPAGEKITFQQFLFTVVAVDQRRIKRVRVYINPEHSDQMKDFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2D9</accession>
    <name>A0A654E2D9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_120448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="9">
        <location>
            <begin position="614"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="814" mass="91511" checksum="67FCB9A1CBD92CE0" modified="2020-04-22" version="1">MKKTVSINIGSIIFHIEEDGYDKLKNYLDSVNRYFSTFEDSGEIIADIESRIAEIFLSKLADGRQTVNLEDVEELIATMGTTRDFEATIEAEPEESKSSSAHEEPKAEEPAPSGSKRLYRDTKRKILGGVAAGIAHYFRIDPLWIRLLIVLLFINVFLGGLSGATFLAYIILWIVLPPNETLEEDQKVKKLFRNSDERVLGGVASGIASYFGTDTTVIRLLFVLSIFLGGAGIVAYIILWIISPEAKTITEKMQMQGEPVTLSNIEENVKKGLNVKEGEESPLVKVLLFPFRLIALIISGIGRVLGPVLRFLAELIRIAFGVLLVIFGVSTMIGFIVAIFGILGIGGWENYVRISDFPIELIQRSLDGWSIGSVFIVMFIPALAVSLLGLVIILKRRVANAYVGWSLFTLWIVALIFAAFTVPRFVQEFAVEDDLRVDKTYPVTAATPTLRLNDLGLDTFDAVDLRLRGHEDSTYQLLLNIESRGKSKRDAQANAQTIEYKVEQKGDDFYFDSKITFPNETPYRFQNVKAYFYIPFGKTFRMEEDLEEILINTLHINGYRPYQMEGNDWVFEQDGIKCLTCPDRSSKSFDKEMNRSEKSASYSGSEKIDYPFEDFDEVKIASFFDVDIRQGDEWQVTVKGNDDDLDEVYLNQVGDRLEVKFKEDSWEWWKDKRSNKVGIFITMPNLEYLEVIGDTDGEVKGFDDDEITMELTGACDLYVNVTPRRLEVQLTGASTMELRGEAAELNADLVGASRLEAFDFLARRVEVSAIGASKAEVNGSEEIEIEAAGVSKVKYRGTRNVKIDEDGISSVDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2E4</accession>
    <name>A0A654E2E4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="65" mass="7180" checksum="7CA66841213130BE" modified="2020-04-22" version="1">MLVISGLEVLQSRPDLINKNSFLNRGNVNFLRIAGSIVRFPSSCIKVCMENRGLAPVLRTFSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2I2</accession>
    <name>A0A654E2I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="127"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32300" checksum="639E061A972A01A3" modified="2020-04-22" version="1">MRLLFTFIVLSSIHLAHGQNYLLPLWKDQVPNQQKTKEVESRDTTDAVRIAYVQNPTIEVYLPGKSQATGQAVVICPGGGYSILAYDKEGTDIAKLLNGQGIAGIVLKYRLPKSQSNIVPHQSALMDAQQAMKLVRANADKWNIDPDKVGVIGFSAGGHLASTLGTHFDDESRPDFMALIYPVISMDTEITHMGSRKNLIGETPTEELVRLYSNELQVQVNTPPTFILHMMDDQVVPVENSLRFYEALRKADVPTEMHLYPAGGHGFGLAIGRGHLASWTDRLIEWLQHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S0</accession>
    <name>A0A654E2S0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Four helix bundle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="116" mass="13143" checksum="CE3411F23C2B41BD" modified="2020-04-22" version="1">MRDFTKYDVWNNAISLSVKIYSLTANYPGEEKYGLVSQLRRASVSVPSNFAEGCSRSSEKDFKRFIEIAIGSAFELKTQLVISNKLGHLSERDFSSVIDDLDIIAKQLNSFRNKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2S6</accession>
    <name>A0A654E2S6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferrochelatase</fullName>
            <ecNumber evidence="6">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hemH</name>
        <name evidence="8" type="ORF">MARINOS108_140035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="336" mass="38770" checksum="52BB58B27472ABF5" modified="2020-04-22" version="1">MKTGVLLVNLGTPDSTEVGDVRKYLREFLTDKRVIDIPAVSRWMLVNLIIAPFRAPKSAAEYRRLFTERGSPLKYYTEDLLEPLRSILGKDYVVEYAMRYQSPSIQVGLDKLREQHVGKIHVIPLFPQYASASTGSVIDKVMEITKTWQIIPEIKFTSQFLEEEKFLQVIVNKGKKRMEKTDYDHFVFSYHGLPERQILKGSVGEQCQLGTCCNQFHDRNRYCYRAQCYQTTRLLADRLGIPEEKYTVCFQSRLGRDPWIKPYTDHVLEDLAKKGKKKVLAFSPAFVSDCLETTVEVGETYKEDFIKAGGEQWDLVESLNDDPLWVECLADLVRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2T6</accession>
    <name>A0A654E2T6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gmd</name>
        <name evidence="6" type="ORF">MARINOS108_20579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="5"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="370" mass="42133" checksum="7B16EF8DFD6985AA" modified="2020-04-22" version="1">MKKALITGITGQDGAYLSELLLEKGYEVHGIKRRASSFNTDRIDHLYQDPHSSETRLFLHYGDLTDSMNLTRLIQEIQPDEIYNLGAMSHVRVSFETPEYVADVDGIGTLRLLEAVRLLGLTQKTKIYQASTSELYGLVQEVPQKETTPFYPRSPYGVAKLYAYWITVNYREAYNMYACNGILFNHESPLRGETFVTRKITRAIAKMALGLQDKVFMGNIDSKRDWGHAKDYVRGMWLMLQQDKSEDFVLATGVTTTIRDFLRMAFAEVGVKIAFKGEGVDEIGYVQAISDAGYAFKVGQEVIRIDPKYFRPTEVDLLIGDPTKANEKLGWKPEYDLKALVKEMMESDLKLFEKDKYLLEGGHDILKQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2W0</accession>
    <name>A0A654E2W0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG family transcriptional regulator (Modular protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_140075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000006">
        <property type="protein sequence ID" value="VXD17510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD17510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="100" mass="11486" checksum="1E75008A77B7218A" modified="2020-04-22" version="1">MSFGILCRKEAAFQLYHDFFVILYYIVLQMKTITIRLSDELESKLSALIDASGNTKSEVIREALEKHLSVKSFQQLRNRVLPFAEAQGLLTDEDIFQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2Z4</accession>
    <name>A0A654E2Z4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hemC</name>
        <name evidence="10" type="ORF">MARINOS108_20310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="4"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="9">
        <location>
            <begin position="224"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD18593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="304" mass="33383" checksum="62A6B8D4E1BB9A57" modified="2020-04-22" version="1">MEIIRIGTRKSKLALWQAEYVARQLQQAGHPTELVLRETKGDKVLDVSIAKIGSKGVFTEELEEQLASGEVDIAVHSAKDMQSRLPAGFEIIAFSEREKINDVIVSEKPIDLKNEQLILGTSSTRRVALFRHFYPNVQTVDVRGNLQTRLEKMRAGLCDGLVLAYAGVHRMGYDPMIRHELSQDEFIPAVGQGSIAIEAHSSLSAEKKEAIRSVLNHQPTESRLLAERAYLARLEGGCSIPVFALANWAGDELVISGGIVSLDGGQRIVKTLRGANPMTLGNQLAEEILKAGGDKILAEIRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E333</accession>
    <name>A0A654E333_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="43"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="156" mass="16938" checksum="8AB557D26C2A0464" modified="2020-04-22" version="1">MKRSANLILLIITVLLSGSSCRDKSEDPKPSHEELQAAILIGINHHRVSLGLTALKENDILDRIATEHSANMADGDIPLSHEGFVQRFEQASKETGASAIGENVGSNYANAAELVKAWLASDENRENIESDYTHVGIGIADDADGNRFFTQLLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E347</accession>
    <name>A0A654E347_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_C25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001769">
        <property type="entry name" value="Gingipain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029031">
        <property type="entry name" value="Gingipain_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01364">
        <property type="entry name" value="Peptidase_C25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024942483" description="Peptidase_C25 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C25" evidence="3">
        <location>
            <begin position="391"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125672" checksum="95B47D17C5D2DB7D" modified="2020-04-22" version="1">MRLLITFLTLSIATWSMGQSVLSNGQWHKVGLTKEGIYKLDKNFLVKEVGINAGFDPRTLKIYGTPHGGMLPQANSVERFSDPQQFAIWGVGDQDGRLDDQDYFLFYSEGPDKLMLDSTGAPVYENNLYSDTLYYFMTTGGEPGKRITTAEIPAPTGSVTTSYYDYITHEIDIENQLRSGRQWLGEKFKKNQDVQQSFEYTLSGSADSVEAWVSVAANSEGPCSFDVSVNNNVLGNIPIEAIQNGVYGEKIKYNAINAKTQVSGNKVTLTLTFQPASGVDTSLGFLDFFVMAIKRKINLGDDKEMIIRLAPGSLRTFEISQATNQSQVWDITDPLNARRLNSSIVNSNIQFSNQYAQQTFVAFDGSDFPSLTYFHPIGNQNIKSLAGNEGLIVTHPDFLDAANRLAAFHQSYSGLSVGVVTTSQVYNEFSAGRQDLTAIRDYARYCYLKSGKIKYLLLFGDASYDYKDRLSNNTNFVPVYESHESAHNILSHSSDDYFGFMEEDEGTWYEGERKENSSTTFLVPYQDHTMDIGVGRLPVKTSEEAHDVVDKIIRYKTATQVFGKWRDQIAYFSDDGDRNAHMIQAEQFFQIVDTTAIEYTARKLYLDLYDQSKDLNPSPAQEAFQNTIKDGVFMLNYMGHGNESQLTEENVITLSVIRNLTNRHKLPLFITATCQFGKYDSPILVSGAERLLLNPNGGAIALLTTTRPVYAHTNFPVNQALHENLFKKIDGRHPRLGDIIRLTKNASLSGPINRNFSLLGDPMLTLNYPEHNISFDQMETEQDTLSALEVYRLSGKITSQGALVPGFSGKAIVTLWDIPQEKVTKGQESDPFTYSDQTNSLFRGEITVTDGRFDTEFILPKNISHKFQPGKLTMYAWNENERTDASGASRNFVLGGIADQVSEDNTPPRIKVFINDSTFSPGGTVGTNSLLIANLSDETGINISDNGFNQGITLRINSGDEIVLNEFYTAHTDTYKSGTVLFPLQNLEAGKYTATLKVFDAHNNAAETTVEFKVSEKPIIRLYNAINYPNPVSQAGETTFRFEHDREDEELEVKISLYNMRGELVQESNFQVDSSPRAVDHLTVRASNYQGAPLDKGVYLYRLKVTSTLDDATNEVIKRLIIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E353</accession>
    <name>A0A654E353_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="39" mass="4050" checksum="C70363F6AA9B9A1B" modified="2020-04-22" version="1">MVMIVSWSSLLLTFIQDIGSVLSGLVGISASSAGIVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E376</accession>
    <name>A0A654E376_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Na(+)-translocating NADH-quinone reductase subunit B</fullName>
            <shortName evidence="13">Na(+)-NQR subunit B</shortName>
            <shortName evidence="13">Na(+)-translocating NQR subunit B</shortName>
            <ecNumber evidence="13">7.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NQR complex subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NQR-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">nqrB</name>
        <name evidence="15" type="ORF">MARINOS108_110068</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:47748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <dbReference type="EC" id="7.2.1.1" evidence="13"/>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00426">
        <property type="entry name" value="NqrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010966">
        <property type="entry name" value="NqrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016055">
        <property type="entry name" value="NADH-UbQ_OxRdtase_B_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01937">
        <property type="entry name" value="nqrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13 14" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="4 13 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 13" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="13 14">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016055-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VXD15905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="396" mass="43114" checksum="BA529D94039DFBB4" modified="2020-04-22" version="1">MKPLQNLFDKLKPNFEKGGKWEKFYTLYEGHRTIAFAPDLTTGNKGTQIKDAVDLKRIMITVVIAMIPALLFGMWNVGHQHFISVGEDAVLLDKLLIGAIAVVPILIVSYSVGLLTEFTFCVIRNHPISEGYLVTGMLIALIMPPTIPLWQVALATIFAVVIGKEAFGGTGMNILNVALTARAFLYFAYPSNISGEVWTYFGDKQPVDAYSGATVLAYGATAVSNGTNMMADMSAHWYDGMYSFWNLFMGLIPGSIGETSTLMCLIGAVILIGTGVGSWKIIASVFGGAYFMGVVFNLVGSNSYMELPAEYHLVIGGLAFGAVFMATDPVSAAQTEVGKWIYGFLIGLLTVLIRVVNPAYPEGIMLAILFMNVFAPLIDYYVVDANKKRRLKRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3A4</accession>
    <name>A0A654E3A4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022134">
        <property type="entry name" value="DUF3667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12412">
        <property type="entry name" value="DUF3667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="258" mass="29882" checksum="A4E51FD325E0D218" modified="2020-04-22" version="1">MPSEMETCINCNQESDGNYCPNCGQKLHLKKLTIRYISSEFTDRWLGLDTKFTRSAWGLFLHPEQVITAYLNRNNVRYIGPLGYYIVMTALMLIAFELLGLEVADFIKSTNENLGLPQGSGSERQLALQENISGWISRNFRFASAFLIPFLTVGVQWLYRKKRSFLENLVLITYLQTHTIWFLIVGLLAFKWTGFWVSQYMTLVSLIYFCWALGRFDDGKITFRKFFKALLTWIVSYLLFIFTILLVAILIVVLVGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3B8</accession>
    <name>A0A654E3B8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBM6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Unchr_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="282"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="495" mass="56186" checksum="CDF81B8C81383B71" modified="2020-04-22" version="1">MKKLGTLVSLIILVSISGYAQRKSEKRGLGYGYHSQKDLEALAPGVSWWYNWFYQPDAGVRDTYQQSGVAYVPMAWNGDFNKTETINFLEANPEVEYLLGFNEPNFKDQANMTPSQAAAKWPELEELASRFDLKLIGPAVNYCGNCVSENGTTYSDPIVYLDDFFAACQDCQVDYVAIHWYGCGGFDWYLDLFKKYNRPIWVTEIACWDQDDISEDQQKSYLINVVDQMENDPDVFRYAWFVGRGDGPHIALLAGDGELTELGQLYVNMPVHDPADFVTLPSRIEAEYYQTMSGIQLELTQDETGLMNVGYLDAGDSLSYQVEVPADRWYTFDLRVAGTANGRVDLMMDGDFIKTIVIPSTGAWQRWQTLEDSLELPSGHHRLTLRVVSGGFNLNWLDILTEREEKLIDPLGLEVPAWARLFPNPTPRYFSIDLQNAAGPISLEIRNMGGEVVWELREAYRQNLSKIDLKGLSSGVYLIYMSNGHMKEVQKLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G2</accession>
    <name>A0A654E3G2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yvqK</name>
        <name evidence="6" type="ORF">MARINOS108_20735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="20864" checksum="D721E5C3C6621E57" modified="2020-04-22" version="1">MSTKLYTKTGDKGQTSLLGGKKVSKSDLRIDAYGNVDELNSFIGLLKDHPEVEARIGNQFYWIQENLFTIGSILATAPGFTGFKLPKVTEVEIKQLEVWIDKASGELPELKNFILPGGHQVVSLCHVCRTVCRRAERSIIALSQEEPVESELIKFMNRLSDYFFVMSRKMAQLLNAPETPWSPGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I3</accession>
    <name>A0A654E3I3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">gltX</name>
        <name evidence="12" type="ORF">MARINOS108_20134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="383"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD18259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="508" mass="56978" checksum="6CA95C467F304379" modified="2020-04-22" version="1">MDSVRVRFAPSPTGALHIGGVRTALFNYLFAKKNNGTFILRIEDTDQSRFVAGAEDYIRQSLEWCGISPDESPWTGGEYGPYRQSERKEIYQSYAQKLIDEGNAYYAFDTPEELDAMRDRLKAAGVATPHYNAAVRLTMKNSLTMPAEEVAAKIASGEPYVIRFKIDPKEEVRLNDIIRGWVHVHGSTLDDKVLMKSDGLPTYHLANIVDDHLMKITHVIRGEEWLPSAPLHVLLYKYLGFEATMPQFAHLPLILKPDGNGKLSKRAADQAGFPIFPLDWQDPETGETSKGFKEEGFIPEALVNFLAFLGWNPGTEQEIFSLEELSNVFSLEKVNKAGTKFDLDKIKWFNQQYLKSTNPQALAEIVRTDLKNHYAIDSSLETALVIVDLLKERVTFPHEMAPNALFIFRNPSEYDQSVTSKKWNEEAEQAVSLYAEALATKESINAEEAKELFFSLMETHGIKAGKNMQALRMVITGAGSGPDLMAIIALMGGKAVAERIKYSVDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I5</accession>
    <name>A0A654E3I5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="100"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="398"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="896" mass="101169" checksum="1AB9ED584C3CC5FC" modified="2020-04-22" version="1">MGQASTQGHLPPRWASRFLEWYCDPYLLEDLQGDLLEIFYRTTSHKGPRRASWQYTWLVLRSFRWSALRKNSKLKNNIIMNSGQHFKVAVRVLWRDKFNTMLNTLGLTIGIVCFVLMGLYVTQEVTFDHFHTKKDRIYRAWLLEDYGEGKIFFNSNTPVRFENLFEENFPEFDEVVQYHLRNFPVSRNQQDVISEPVAVISPEFFEVFDFDLIHGNVTEPLSGRYDLIISRAYAEKYFGDEDPIGKTLQLQFDEDVTPFTITAVLDDIPQSSSIKFDLAISNVLNRELMGERALTAWMMVGPETYVLMKDQTSIETVNAKSQDVVMSYLGEEMNRDEYNIGFQPLTDIHLNPEIPAGIAPVSNPVYVYVLGIIGLLVLFIACINYTTLSIGQSIKRSREVGMRKILGAAKRTLIFQYLSESVLVALVSMLVGGLLAVLLIPTFNRLTGTELVYVFEMWHLAIFFLIALCIGTLAGIYPAIILTSTKALAIMRSGSTSRGKHWVRKVMVTFQFVITVLLISSALIMQKQIRFLQDKDLGFEYQAFVSVPLFSSSESGRTTERIASARANGALLKPKIEAHPQVSSITMASHAFGTPGWAALSFTDDKGIFRTFSMLAVDAEYLSAFDIGIVEGRDFEKGSGLDERQSILLNETAVDYFGFENPIGKKLPGDNFGEHRIIGVVKDFHFSSLHQEIAPLVITQNVLPMFLGISDAEVKDSMIPKLLFKFTGSQLSQVQEILTEAWESTFPNRNLEYTFLDENVARQYENEARLNKLIGVATVISILIAAIGLLGLTVLVVNSREKEIGIRKVIGASPFQIFHLLARTFSWQLILGVVLSIPLTVWLMQQWLEDFAYRVGIGVDMFALSTFISFFVALVVIGFQAWKAAVVNPVKSLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3I6</accession>
    <name>A0A654E3I6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="84" mass="9593" checksum="FB00E9D8606B4569" modified="2020-04-22" version="1">MRLPIIKHIIDFVDENDEDWVVETIELLEHMSEAKGIKDEELDVIGELLSNMYGALEVHKEIKNGTPQKEALNGFMKRVMGAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3P8</accession>
    <name>A0A654E3P8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopenicillin N synthase-like dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="320" mass="36179" checksum="DC2CB1FF2435729C" modified="2020-04-22" version="1">MNNTLYSEVPSLDLADFTSGDAATKSKFVNDLGHAYQNIGFVAIKNHGLSDDLTKQLYESVQKFFMLPDEVKLRYEKKELAGQRGYISKGREKAKGRNTGDLKEFYHVGQPTENKLDEYPENIWPEEVPEFEALTLEAFKTLQEAGIQMLRAIALHLGLDELYFDDKVRQGNSILRQIHYFPIENPDEIPADAVRAAEHGDINLITLLMGASADGLQVLRRDGTWIPITALPDQIVVNVGDMLDRLTNHKLKSTIHRVVNPPREKMGTSRFSIPFFMHPISSMDLTCLDSCVDADHPKQYEDVTAGEFLDERLREIGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3R6</accession>
    <name>A0A654E3R6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="291" mass="32199" checksum="791BE8C4322BF7DA" modified="2020-04-22" version="1">MGDEKEKKYRKIGWFTSILVQVIMLILFYFLIAWKEPFPPIPSYGIELSFGIEDAGSGEKPLSNPTPTEEPEEEMEEVSADESVNQPLEETAEFEDEVLEEITEPTEAPLVETPSPDVVEKKTETPKVEKPKEEVKEVKPAKTQPKEAEKVTKETLNPAATMPKTEGDPNSTKGEQKEKGAEGKEEGSIDGRALMGEQGSSDGASLQMAGWVWDVKPNPKDASSESGKIVYRIKVDSDGYLTGIELVSSTVSPVVERYYRQSVERLSFTKTNDYSPAPISSGTITFIIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E459</accession>
    <name>A0A654E459_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD18667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="340" mass="38990" checksum="0849980324B0A29D" modified="2020-04-22" version="1">MYININDSLQLASKLTLKRLINAFHVYTSFRKSRKTGTPHIKGLPISLSIEPTTACNLRCPECPSGLRSFTRPTGKLDQQLFKTILDEIGDTLAYLIFYFQGEPYLHPQLLNMVKYATDKKIYTATSTNAHFLTDEIAKQTVESGLDRMIISIDGATQETYEAYRKTGELNKVLEGTENILKWKKALKSRTPFVVWQFLVVRPNEHEIPEIKKMGKAYGVDQVVFKTAQIYDYAQGNELIPTQDKYSRYAPLPDGTYRLKNKLLKECWKMWHSCVITWDGKVVPCCFDKDAHHVLGNTSHQPFKDIWHSDGYASFRKTLLTSRDEIEICKNCTEGGKVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E498</accession>
    <name>A0A654E498_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_20913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="251"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="470" mass="53163" checksum="BF6543220C2BBAC4" modified="2020-04-22" version="1">MTFLKIKLRSPAINIKDALVLRFVLIFGVLWVLASFSIYYSSAQFRHDEFYQRLHTRASTAAKLLIEVEEVDASLLRKIEDANPIKLPGERITIYDYNNVEIFSTDTQDSIRMDEERFNDIRLEGEYRWRQGSVEVLGLLYTDQYERFVVVAAGQDVYGFRKLDNLRNILLTVFFISLIVIAMAARLYAGNALRPISEVVEEVNQIGISNLGKRVSEGNGKDEIATLGITFNRMLDRLQSAFESQKSFITNASHELRTPMTSVLSQVDVALLKDRDAKHYKGTLQSVRDDIQELSALAGKLLLLARVDAFRETFEPIRVDSILWQAISEVSRHFKNNILVDFSSDIDDEQFFTIMGNEQLIRSVLQNLIENACKYSEGKDVRVLVELAAEGLCLKVEDQGVGIAPEDLPEIGQPFYRGKNTSGFSGSGIGLNLSKKIVELHHGTFSLDSRMGEGTRVSIVFEYLGFLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I2</accession>
    <name>A0A654E4I2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="71" mass="8114" checksum="EAEB964D0582EEF5" modified="2020-04-22" version="1">MWEILALLVFSGFVLRWQKPNVLKCAMGLRHGMKPNDKLKSVGWTFVNIGKESKPTNPSKYLSKPMDFSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q2</accession>
    <name>A0A654E4Q2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ORF">MARINOS108_120472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD17076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="200" mass="22551" checksum="FAB5F9675DA22F40" modified="2020-04-22" version="1">MARYTGPKTKISRKFGEPIFGASKALQKKNYPPGQHGRGRRRKQSEYAIQLAEKQKAKYTYGVLEKQFSNIFEKASRKSGITGEILLQLLEARLDNTVFRLGIAPTRRAARQLVGHKHITVNGDIVNIPSFTLKEGDLIGVREKSKSLEAISDSLSGNAKRYSWLEWDASGMVGKFLNSPTREEIPENIKEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4Q7</accession>
    <name>A0A654E4Q7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxymuconic semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dmpC</name>
        <name evidence="6" type="ORF">MARINOS108_60141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.85" evidence="6"/>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD21027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="15"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD21027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="475" mass="51537" checksum="455B35EC40D83416" modified="2020-04-22" version="1">MIVIDNFIGGEFHKPKSGQYLDNINPAVGEVFAKIANSSAKDLEVAVSAASGAFHEWSRKTLAQRSKILHRLADLIDENLEALARAESQDNGKPVALARRVDIPRAAANFRFFASAIINESTEAHVMEGHAVNYTRRAPLGVVGCISPWNLPLYLFTWKIAPALAAGNCVIAKPSEVTPYTAFLLCQLANEAGLPPGVLNVLHGRGAEIGQLLVDHAEVKAISFTGGTQTGRIIGQAAARQFKKVSLELGGKNPVVVFDDCNFEEAVQTTVESSFTNQGEICLCGSRIFIQKGIYEQFKAAFVERVKALKVGDPATEVDLGALVSHDHLEKVDSYVSKARTDGGKVLAGGSRITLMNGYYYEPTVIEGLDEYCQINQEEVFGPVVTLMPFSDEADVISKANSTPYGLAAVIWTENLKRAHAVAHQIKSGIIWINCWMLRDLRTPFGGMKSSGVGREGGSEALRFFTEPQNICVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4R6</accession>
    <name>A0A654E4R6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">panD</name>
        <name evidence="14" type="ORF">MARINOS108_20806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5025722468" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025722467" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="37"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD19663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="128" mass="14212" checksum="F625DD9C35C2956D" modified="2020-04-22" version="1">MITYICGKIEAEMTIEVLKSKIHRVKITQAELHYVGSITIDEDLMDAADLVENEKVQIVNINNGERLETYVIKGERGSGQICLNGPAARKAQVGDIVIIISYCSVEKEKAKAHTPVVIFPDEKNRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4U9</accession>
    <name>A0A654E4U9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="94" mass="10463" checksum="DBE41DCCA3B3F1C2" modified="2020-04-22" version="1">MKTILQFALAALLFGCNPSSGSREAYYVSKISQEKDGKTLHLKDQNNNEFTTVISIPNGNYIEVNEGDTISIEIESIIETYPPILISKDIKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4W1</accession>
    <name>A0A654E4W1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024997283" evidence="1">
        <location>
            <begin position="18"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="3">
        <location>
            <begin position="70"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="318"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="657" mass="74575" checksum="369D302101D41FE1" modified="2020-04-22" version="1">MKSLTLLFLVLSLHAFGQKSNIKFGKVTEEELTLTECAFYPEANSMVLGEFGTLNFMYNNDKGWSYNLVVHRRIKVFNKLDKDIANIKLRVYDPLKGNSKEEIGAIKAFTYNLVDGKIEKTKLTNSEEYTTRINDYRMETSFAMPDVREGSVFEYQYTLSSDLISTLSAWHFQDDLPVEISEFRYTIPEFFKYTVSQVGSFVVLDRKEENVNETFTYRWESVGAGGNVERGTGSLPSVSVHTTQTGHNLLPLQDEPFMNNKPNVPARLEFQLMSIHMPNRPIKMVAGNYEDFNKNIMDWTSFGKTLNNGNFAKDKISTLSEDPTTRAKEIYTWLANHFSHNDVFGFTSDRVGRSAFNDGQGSVADINLTLVAVYREAGLEAYPVILSTRGHGIPHPIYPNYEDYNYVIAAVKTPEGTVLTDGASKLPFGMLPTRCLNNRGWMATENGGSWIDLKNDASHSITVISQFDFEEEKLNSQYSVKMDGYAETEAHSNVKSGGQEHYNESITSHFSEWEMDSLKIDTETGFNLNFAVAKDIDDNATVYLQPISYGMVTENPFKREERLTPVDFPYQINRRVIVKIAVPEGFSAELPESTIVTLPNNGGKFIYSINQIGSNIQIMSMFKLNQLDFSPDEYPYLKQFYQLVAEKNNEIIVLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E511</accession>
    <name>A0A654E511_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein MARINOS108_90056</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="192" mass="21870" checksum="9E3ACF4722085726" modified="2020-04-22" version="1">MDYFATDQIIEPERGDLLISEPYLPDPNFERTVILLCEHDENGSFGFVLNKRAQSRLDELIEEAEGFSTDVFVGGPVQQNTLHFLHKSPATLKGDKKVVDGVYWGIDFEGLLSSINTRQVAKEELKFFVGYSGWSPGQLMDELKSKSWIVYKKASPEVVFEMNPDDLWREALKTMGGKFRVISNYPTDPRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E535</accession>
    <name>A0A654E535_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SusD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_90076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="89"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="407"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="526" mass="60279" checksum="DBE8DEB35ACF8A56" modified="2020-04-22" version="1">MIMKNLLKIFLLGISLSSCVDLDEEVYSEVTASNFYQNEEEVVSAVMRPYAHLRQVFLNFSTNGCGVFLLQELSTDEAAWPTKGRDGFDNGNWIRLHRHEWTVEDGSFAISWNDMYKGIALCNNLLFDFKDIDAVNSTDKLQYQAELRGLRALYYYYLLDLFGNVPLVTAINQFSPSNNTRVEVFNFIEEEILDIRTNLPKKGDIGWYGRFTQEAANGLLSRLYLNAEVYTGEARWTDCIEVSRLVLGSSFSLEAQWDAPFKTDNYASDENVFAIPADELFGNDLQQMFQFTTHWQQREPQFGYQGNGGYNGMVSVREFIETYDTLNDARCFFDSRVFIPGNENDPTLLRGQFMWGPQYGRDGNPILGTNDKNGQHLVFELDVPNMEDGNEASGARNIKYQVEYGAVGFSNDIVLFRLAEIYFNIAEASLRNGGIVPQDVLDAINVIRNRANVPTYQNLTLDELYDEKGREMAYEGLRRTDMIRYKKYTGNWWDKEVSDGFRTLFPIPQSSRNVNPNLDQNPGYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5C4</accession>
    <name>A0A654E5C4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-(Ms(2)io(6)A)-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045301">
        <property type="term" value="F:tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07910">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010386">
        <property type="entry name" value="tRNA-Hydrxlase_MiaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42637">
        <property type="entry name" value="PTHR42637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06175">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020736">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="194" mass="22947" checksum="B573AB80888EBA52" modified="2020-04-22" version="1">MKQRIDLKVESSQEWIDTVVSDFDEFLKDHANCERKASAMAMSFVAKYPNRVEIIPELINTAVEELEHFRSVYAIMEERGIELTHEIGQDIYVKQLLDKCRDGREERFMDRLLLASLVETRGAERFRMVYEAMDDPELRRFYQELWASEAKHGEVFVRMALNYFEEKAVYKRLEEMTDYEAVVLQSLPLKPALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5D1</accession>
    <name>A0A654E5D1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="98" mass="10834" checksum="E6CAD758580AD67B" modified="2020-04-22" version="1">MSSRGNSFFAFILGAITGGVLGVLFAPDKGTNTRDKLTYRLDKYKKRLEEIVEDLVEGADMVENEAKSEGEKIVKDAKVKAEKLLDDVNGLIDQIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5J7</accession>
    <name>A0A654E5J7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proS</name>
        <name evidence="9" type="ORF">MARINOS108_20008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD17974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="39"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="491" mass="56098" checksum="96C7A6AF630BE042" modified="2020-04-22" version="1">MSKAIPSRSEDYSLWYNELVKKAGLAENSPVRGCMVIKPYGFAIWEKMQQTLDKMFKETGHSNAYFPLFIPKSFFSKEASHVEGFAKECAVVTHYRLKNDEVNGGVMVDPDAKLEEELIVRPTSETVIWDSYKNWIQSYRDLPLLINQWANVVRWEMRTRLFLRTAEFLWQEGHTAHATRQEAEEETVQMLNVYAEFAENFMALPVTKGIKTENERFAGAVETYCIEAMMQDGKALQAGTSHFLGQNFAKAFDVKFANKEGKEEYVWGTSWGVSTRLMGALIMAHSDDEGLVLPPNLAPIQVVIVPIYRKDEELEKISEVAEKFTKELRAKNISVQYDKRDTHKPGWKFAEYELKGVPVRIAIGPKDLEKGTVEIARRDTKEKQFVAQGETVEHIVTLLDDIQKNIYQKAASFKEANTHQADSYEEFKEVIEKKGGFVYAHWDGTSETEEKIKEETKATIRCIPLNSNQEEGTCIYSGKPSKGRVLFAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5P4</accession>
    <name>A0A654E5P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="38" mass="4481" checksum="B0ECFF5CC6DAE021" modified="2020-04-22" version="1">MHGSVEVLVEFLNEIFQAEYIFKVRYNSITTVYVIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E621</accession>
    <name>A0A654E621_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">proA</name>
        <name evidence="8" type="ORF">MARINOS108_90094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD21381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="418" mass="46167" checksum="C40466DDEE6E49A5" modified="2020-04-22" version="1">MKEEILKSLKGVQTASRRLVSLEDVQIRQILNEVADLSWEKKDSILAANQEDLSRMDPEDPKYDRLLLNDDRLKSILEDIRRVAQLPTPLGQQLEERTLPNGLMLSRVSVPIGVIAVIYESRPNVTFDVFSLCLKTGNACVLKGSRDAKDSNAAIVAVIHEVLKAHQLEEVVYLAPAEREALQPILTAEGLIDCAIPRGSQGLIDFVRKNASIPVIETGAGIVHTYVDSSADLVKAKAIIQNAKTRRVSVCNALDCLVLHRSLLSDLPQLLAGMDEHHQVGIYADEESLKVLTGHYQSDLLHPANEEDFGIEWLGYKMSIRVVTDLEEALEHIARYSSKHSEAIVAEDQQTIDQFLKQVDAACVYANASTAFSDGGEFGLGAEIGISTQKLHARGPMGLREMTSYKWVVRGDGQIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E639</accession>
    <name>A0A654E639_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_90075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LamGL" evidence="2">
        <location>
            <begin position="149"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="354" mass="38200" checksum="DB492B2B4812A5EF" modified="2020-04-22" version="1">MIDFNNKTKIYGIRALVLSLGVLVIFTLNSCGDDGEDKGPNTDLTALTAEISTVETLLSSSVEGNGVGEYYKNSKEPLETALADAQTVSNNEAATQEEIDAALTSLEDARFAFAAREIEDAALQFSANGSENAIAVEQSSNSASIFNRGEFTFETWVYYTDKPGFFGQMASTEFYADGVWGWNVRVGDGDALDFAIGDADGESRLQPDVTAVPGAIVPRNEWVHIACTFDGTTMKSYINGNEIGSLDASDRDRMGEVAAQEGAQPLTLGNSAGFKQPERRLVGKMFDVRYWGVARSAAEIKEDMDFIIDGDETGLIGYWPFAKPATTDLITDWASDTEGENNLSLVDGAIVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E689</accession>
    <name>A0A654E689_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_60050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD20861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="133" mass="15030" checksum="BB789951A1A27386" modified="2020-04-22" version="1">MDDVIQAKVATIEKCLKRIQEEASHDWKNNFTHQDALLLNLERACQAAIDCALHIVRKKHLGLPKITREAFDLLNNAGIIDSPISENMKKMVGFRNLAVHDYATLNLDILEAILTRKLTVFSSFCKTVINLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E735</accession>
    <name>A0A654E735_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane receptor protein involved in Fe transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041700">
        <property type="entry name" value="OMP_b-brl_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14905">
        <property type="entry name" value="OMP_b-brl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="149"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl_3" evidence="3">
        <location>
            <begin position="381"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="814" mass="91945" checksum="FD513EFB33EF9762" modified="2020-04-22" version="1">MIRNTYTFLFIFLFGITLHGASPIEEAPSIRGQVIDAGTGQPLEFATVSVVRADDKSLITGSITDAEGRFSLAVEPGEYVVKIQFVTFETKEISVIVGQGNRNPDLGTISMKPSVSELDEVVVSGERTQMQLSLDKKVYNVGKDLSSLGGSASDILGNLPSVTVDVEGNVELRGSSSVKVLIDGKPSGLVGLSSTDALRQLQGNMIERVEIITNPSARYDAEGMAGIINIILKKDKGNGLNGSFQVNTGYPHNHGASANVNFRKKWVNLFLNYGVNYNKAPGLGGASQQYMLPDTSYTTDLSRQHIRGGISNNVRFGADFYLNDYSTITTSFLYRYSDELNDSELEYKDYDGNEQLIDYTRREDTETEGDENLEYAVNYTRTFQRQGQKLTADFQYQNNNELEKSDIVQYQGATMAESVPELFQKVRNDEGEKRLMLQSDYIQPFGQKGKVEAGFRSTFREVKNIYNVQEKNDPSEAYVPLDTFSTDFAYNEDVHAFYGIVSNELDKISWQLGLRSETTSINTVFQETGKQRNWQYTNLFPSAFFTYKLKGENQLQLSYSRRINRPRFRELNPFSSFTDNRNFRIGNPELQPEFTDSYETGFLQNLKASSIYYGVYYRHTTQLIRRVSLAPNESGERVQIPYNIGESDALGMEINAAHEFTSWYRVSGNFNFYHQQITGTVGDTINLGARTTTFSTRVSNNFKIPKLFDAQVNVNYQAPQNQSQGRRLSVTVVDVGLTRDIWKNNGTISLSARDLFNSRKWRSITDIPTFYEESTWQWRKGPTFVLTATYRLNQKKQRPERGAGRDEFEGDGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7L9</accession>
    <name>A0A654E7L9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracycline resistance protein, class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tetA</name>
        <name evidence="8" type="ORF">MARINOS108_20698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="7"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD19341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="404" mass="43421" checksum="AB47BD34EA341ADC" modified="2020-04-22" version="1">MKNQKAALGFIFITVLIDVTGLGIIIPVLPQLITELTGGTISDASIYGGWLMFAYAFMQFLCAPVLGGLSDQFGRRPVLLFALFGFGIDYIFMALAPTIWWLFLGRIVAGVTGASFTTASAYIADVSTPEKRAQNFGMIGAAFGLGFIVGPMTGGILGEFGSRVPFYAAAGLTLVNWLYGYFVLPESLSPENRRKFSWKRANPWGTLVQLRNYPTVIGLIASLVLVYIAAHATQSTWAYFTIEKFDWSEAQVGYSLAFVGFMIALVQGVIIRPVVNKIGQTNAVYAGLAFNALGFIMIALATQGWMLYAIMIPYAFGGLAGPSLQGIMSNSVNANEQGELQGGLTSLVSVTSIVGPPLMTGIFGYFTATETDWYLPSAPFYLGAVFALLSLVFAVRTLSAKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7P0</accession>
    <name>A0A654E7P0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_20718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="418"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="660"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD19396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="774" mass="87551" checksum="5748F7CD0AC07550" modified="2020-04-22" version="1">MNGKFLLCVIVLFAIGMNVTAREAQKGVLDLRDADLSAAPVPLNGEWTFFWEQLLSPDAISSSTQDFFYFPELWNNHSSHGGVSLSRNGFATYHLTILLPRDRTDLALRIKHVYSAARLYIEDERIDFGGQVGMDPATSDPKWVPQIIELPDQDTVRITLQISNFSHRKGGAREAILLGDEAFLRSQANELLAFDLLLTGTLVMTGLFFCALYFFGQREKSAIFFSVFCLTFSYRVVGADDYTLQIIYPGMAWLTSIRLEYLSLFVPPIFFTLYTHALFPLKYRVNPLYVFVAISILASGITLIFPPTVFTSLVDAYLILLLAGILIVAYVYIRAYQRNMEGSRYALISSLMILMIFSYKIYLYMGAAEEIELISFVGYLAFFFFQSLILFFLFTNSLKEAKEQAEHAARTKSEFLSMMSHEIRTPMNAVIGLSNYLLGDQPTKNQEETLNTLKFSAENLLVIINDILDFSKIEADKIEFEYRSVDIRSLIENLNRVFLPIADAKKLKVVFECDDRIPQFISCDQTRTSQILTNLLSNAIKFTEEGVIRLSLKCESQTNDHVVIKFEVADTGIGIEKQRQEDIFQSFTQASSSTNRRYGGTGLGLTITKKLLKLQGSDLMLESELGNGSLFWFTQQFAIVEDIILESMPDNIEEQQLPLDVLLVEDNQINVMVASKFLNKWGASVTVAANGIEAIEAISTRNFHVVLMDLQMPVMDGFEAAEEIRKKNNLTPIIALTASALPEEQKKIRNSGMNDYIIKPFDPGELLKKLRHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7Z6</accession>
    <name>A0A654E7Z6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="18060" checksum="264EFA9D311AC966" modified="2020-04-22" version="1">MNQTARKIVNRSELPALVEQWREDRQQIVFTNGCFDLLHLGHIDGLEKARRFGDRLIVGLNSDTSVKKIKGPDRPLNNENIRSRMLAALEFVDAVVIFDEDTPASLIGEVLPDVLVKGSDYQTGNIAGSDIVLRTGGRVELIELTKGFSTTSIIEQIKRTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA01</accession>
    <name>A0A654EA01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argD</name>
        <name evidence="3" type="ORF">MARINOS108_90092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD21377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="375" mass="40643" checksum="DA48E9F00BF0E4C4" modified="2020-04-22" version="1">MGLFNVYPLFPIEITRGEGSYVYDTAGIRYLDLYGGHAVISIGHSHPRYVQRITEQVQRLGFYSNSIQNPLQEELAVKVGELSGRPEWDLFLCNSGAEANENALKLASFHTGRKKVISFTNGFHGRTSLAVAVTDNPGIVAPVNATDNALILPFNDEEALEMAFANDEIAAVIIEGIQGVGGIFLPDESFMKKIRSLCDIYGTVFIADSVQCGYGRSGRFFSQDYYGVEADLYTMAKGMGNGFPIGGVLISPKFEAKFGMLGTTFGGNHLACAAALAVAEVIQEEHLIENAGAIGDYLMGELAGISAVQEVRGKGLMIGIDLEYPAADLRKKLLFDHHIFTGSASRKNTIRLLPALNLSKEDADHFLEIFKSAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EA21</accession>
    <name>A0A654EA21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_90112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="229" mass="26809" checksum="EF89DD7C16B2EC5C" modified="2020-04-22" version="1">MITTYQNQKRLLVAVDCIIFGFDDEELKLLLIKRNLEPEKGKWSLMGGFLREDETASQAANRILHSLTGLRDVYMDQVRTFSQPDRDPVERTISIAYYALIKIEDHNKELSRQHSAEWFSLNKAPKLIFDHGDMVTTAINLLRYKTSVQPIGFELLPEKFTMRQLQKLYEAILDQELDKRNFVKKINQLDVLTKLEEKDMTSSKKGSYLYQFNKEKYASESKRDFSLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EC12</accession>
    <name>A0A654EC12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="58" mass="6798" checksum="4C6886EDE2AE9C7B" modified="2020-04-22" version="1">MYHTELETEIISKMKGLNGNQKSAVLNYLEKIPKMSHSTRMYRRKAMKQIREALSGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSM4</accession>
    <name>A0A654DSM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_10008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="498"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="567"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD10340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="780" mass="87898" checksum="2A25FDD1E0A3A95A" modified="2020-04-22" version="1">MIYQFSLIYRSVSYLTILTALVVMYGWLRGIELVQIIVQSWPSMKFNTALCFFLLGGVLLCTLYRKKLFKILLGGVLLFVASISFIENLTDLEVGLDVLLVPGLMSAGTALCFALMGLAHLVIYADSVEWRKMSQYLLHSVTVISFFAMIGFVYGISGEGKLMFISSMAIHTSALFFLSSIASSLIHPSLGFTALLIGKKPGNLLAKRMFPLMGSLILVLGYLVIKYWETGEISPETGLTLFGMSILIIALTFISMIAMELNRTDIKRSEAVRALRDSNANLEKTVAERTALLKDKMELLNATTSAARIGTWEVDLEAGKVTWSEMTREIHEVPIDFEPDLTTGINFFKEGAHRSRIEATVQECIATGKPYDVELMIVTATGEDRWIRAIGTPILRDDKVIRLRGTFQDIDVRKRAEIKISEESIFLQTLIDNIPINIYTKDLLSRKTMINRSELELMGLDNSSTVIGKTDHELFPKESADISRKEDVEVMKTGIPILSRETSMDLGENNKHWFLTSKIPIKNSEGNVTGLLGVSVDITERKENEEKLKNYAILESKSAEMEQFAYVASHDLREPVLTIKNYLNILFEDYGEKLGEGSKRYSNTILNALNRMELLIGGLLDYARLSRQKSLEQVDLNEAVKNVLESLDSLIVNSQATVKVSKLPRIKGYPIEIELLFQNLITNGIKFHHPDRLPVVEIERKKYGSGWMFLVRDNGIGIEPEYIEEVFVMFKRLHSRRLYEGTGIGLSHCRKIVELHNGKIWVESEPGIGSVFYFTIDINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DSP4</accession>
    <name>A0A654DSP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MARINOS108_10028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD10385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="186" mass="19878" checksum="571C528F63F64FE2" modified="2020-04-22" version="1">MKELITAPWPWYVAGPLITLVMVLMLLFGKSFGISSTLKTVCSIGGAGRWSDFFRFDWKSASWNLFFAAGAIIGGYIASSYMAPEQAIALNPATVASLQTYGIDNAGAEFLPREIFNLQNLLTGQGLIFMVLGGFMVGFGTRYADGCTSGHAISGLSNLQWPSLVAVVGFFIGGLIVTHLILPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT77</accession>
    <name>A0A654DT77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acsA</name>
        <name evidence="3" type="ORF">MARINOS108_10228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="2">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="99"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD10782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="655" mass="73738" checksum="E25CF4F93C0DCC1E" modified="2020-04-22" version="1">MTPKHPKILWSPSDSLKADSNLAAYMSWLHDERGLTFSNYDALWEWSVSDTRAFWQSIYEYFKVISHHPYTAVHSDDLMPDTRWFDGATLNYAEHIFRNQNEQHPAIIFRAEGRNTVEISWRELRDQVAAMASFLKARGVEKGDRVVAFLPNCPEATVGFLAACSLGVIWSSCSPDFGPSSVVDRFQQITPKVLITVDGYRYGGKEFDKSAVVREIVDRLPTLETIVEIPYLQNEKLLTKSVSWAEVVRTPFEGLDFTPVDFSDPIWVLYSSGTTGQPKAITHSHGGTLLEHLKYVSFHNDVKPGERYFWFTTTGWMMWNFVQATLLVGATIVIYDGSPGFPDLGVLWQMAQDHQIQHFGTSAPYIVACMKAGLAPGRDFDLKTLRSISSTGSPLPPEGFDWVYEAVKKDLWLCSMSGGTDVCSAFVGGCPLEPVYEGEIQRRALGCAMYAFDDEGKPLVGEVGEMVVTSPMPSMPIYFWNDPDKVRYRESYFEMFPGIWRHGDWLSITERNTLVIHGRSDATLNRHGVRIGTAEIYQSVSKIETIVDSLVVNLELDGGRHFMPLFVVLKEGQALDDQLIKQIGHQLKTDFSPRHIPDTVVLVRDLPYTISGKKMEAPVKKILMGKPVEKAANLGAMRNPESLDFFVTYAKQVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DT97</accession>
    <name>A0A654DT97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="342"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="728" mass="82819" checksum="E7B822BF197FB927" modified="2020-04-22" version="1">MKDILLITPPFTQLNTPYPATPYLKGFLNTIGLEAYQMDLGMEVILALFSKDGLQNLFAEAENDQTDWSENALRIFALQEDYQHTITDTMAFLQGKNPSFARQICSGQYLPQASRFDQPDELDWAFGSMGFQDKAKHLATLYLEDLSDFIVECVDENFGFSRYAERLGRSANSFDELYAHLQQPPTFIDQLTIQLLKELLEPHTPQLICFSVPFPGNLYSAFRCAQWIKSHYPHTKIAMGGGFPNTELRSLSDPRVFSFFDYITLDDGELPIELIAEQTLHPDRSVLLKRTFLLENGKVVYQNSSPRPDYKQTAVGTPDYSDLPLSEYISVIEMANPMHSLWSDGRWNKLTMAHGCYWGKCTFCDISLDYIRLYEPIAARTLVDRMEAMIAQTGEKGFHFVDEAAPPALMREVALELIRRKLSVTWWTNIRFEKSFTHDLCVLLKASGCIAVSGGLEVASDRLLQLIDKGVTVEQVARVTSHFTDAGMMVHAYLMYGYPTQTVQETIDSLEMVRQLFELGVMQSGFWHQFALTAHSPVGLNPDAYGIQPVHNDISFANNDIQFSDRTGIDHGQFSFGLKKSLYNYMHGIGFELPLQEWFDFKIPRTSVKRDFIENCLETDTEYLIRPTARILWLGGTPAISYSSRTKKGKTKEMMHLTIQTRTDALQVNLEKPKGQWLLAQLAQLTPNHPARTLAQLKAGYDAEFGAFEQFWYSKPIDLLRDHGLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTL1</accession>
    <name>A0A654DTL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD11172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="44" mass="4915" checksum="E9914F3DF28A11BA" modified="2020-04-22" version="1">MNHFLDIVLSGKIVNSLESRKIVKSASASNVCRKQCVQKDEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTL3</accession>
    <name>A0A654DTL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Por_Secre_tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18962">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Por_Secre_tail" evidence="1">
        <location>
            <begin position="292"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="363" mass="38838" checksum="DF623AA36C07F3B4" modified="2020-04-22" version="1">MFNTAFAQTSVADGPWGNGATWGGSSPGFTGLNNPIINSYVTVGSDAANQSLTFANSNGRTLTVNDTLIVFGDVTFNITKNNAAVTIGAGKVLIIFGDLEMGKNNAGVDVGTGGVLVVTGNITADGNNGVITGPGSVFTSGTSNMTGNNSGESGDLTALQNSTQFEEVAKYVNGDKDVPLPVKLLYFRAEVSSFVTLRWATASEIDNDYFSVERSENGIDFYQIATLMGNGTYDGLLEYEFIDEKPQSVVEYYRLKQVDFDGVSETFQPIRVETSSVMPKHKISLYPSVVENGQLNIVSDQSLYIHDLSVYSMKGGDMISVGNSQRSTDNAYSLAVDQLASGLYVLKVQTTEGETFTSRFVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTR1</accession>
    <name>A0A654DTR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD10539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD10539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="162" mass="17696" checksum="59A85552841BB96D" modified="2020-04-22" version="1">MKNKIYKAAIILSMGFITYVNPTETMAQTEALSSNQNSNDMSSFISIFEIPATDLSRAVNFYQAILNIKIEKMEMPGMEMGIFPYEGQLVTGVIVKGDGYNPSADGVTIYLNGGDNLQIILDKVEESGGKIIVPKTPHADESGFFAMFLDTEGNKMGLHSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTV1</accession>
    <name>A0A654DTV1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="47798" checksum="3DC9B4DBD9E1DFFC" modified="2020-04-22" version="1">MKKSILILLVFAFFGCQEKENTQLFIRAFKAAQQKDYFTTKDLFDANKESFSTAQFHILQAITTNAFNQIELSEESINVFLRNHSASAPDSINQMIWDIRHDNAYKKYQYKKAKESVRFLLTNYSSSLSQEEIDDYENSLKLWTILEDQPAQQIIIESGVEIQMSRDLAGLRNLPITSGSDTTNFIFDTGANLSTVTRSSAEKLQMTILEDSILVGTITGDQVYAQLAICPEFFLDQIVVKNAVFIVFDDDKLAFPQINYQIHGIIGFPVMEALDEIRISQSDLFTANTSSDELQPSQNLALDHLNPIIHVDGKHYSFDTGADETMLFKRYYEENKESIASSSTLTDIQFGGAGGQTNQTGYRIKFTASISGRTLELNNIPVLREEISQKWNGLYGNIGQDVIHHFDVMTLNFRDMYIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DTX3</accession>
    <name>A0A654DTX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="463" mass="49757" checksum="5542131915CD6515" modified="2020-04-22" version="1">MSNRGSFSNKLGFILAAAGSAVGLGNIWSFPFEVGAGGGAAFLLVYLFFCFILCFPVMVTEIAIGRKTQLNPAGAYEALGFKKWRILGLLGIISGVVILSFYNVVAGWAFGFFIELLTGHFEIGSQFSTFIKDVFKVGLYAMVFMFATAFIVSKGVSGGIERASKILMPTLITMILGLVVYSLTLDHAFEGIKFYLVPDFSELTLSVMGNAMGQAFFSLSLGMGALITYGSYVGKNDNIVTSAAFITLADVGIAFIAGLMMFPMVAYLTDGTMEGAGQGAGLIFTVLPGAFESLGPLLGVVIGSLFFLLLSFAALTSTVSLLEVPVAYIVDEKKIKRNRAVWIMATIIFVLGIPSLLSNGYSGFFSSFITYVGAENATSFMDFAQNVANDTFLPLGGCLISIFAAYAWKTKNLNEEIALGYPNYMGSFIQKYLNFAVTILCPLVLGTMFLLTLLQTFFGVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DU39</accession>
    <name>A0A654DU39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="485" mass="52099" checksum="99C5F0CB282C5293" modified="2020-04-22" version="1">MPTSIPYDHPSLTLGAVVDTQVLDSLDQVATLNQAIDAAQDKMNSLIMMKRSLAMTLNELLDMNVDVSDLKSEMKALDPQISQAATGYLNTRLKNETSIQKVREQLAELKQSHIESPVDFVKSTITQQPLAYESMKLDAQYFSFGGNLEDDTLSNIETYVKEANSDLGKGAADLAKQATSQIQQQHRNHSISGTLIITACCMHRNVTLIEPLVLDLQKAVSIWNATVGKGDPIDTNDLASGPANSKPSTSESPSPGLSIISGAAYGSSFVGMVHILNTDSDGPAEEKIASLQEKLQLGGWLENLSGGFGVNESTLSEVKKTLSTQQVSSHVSLITMGAIPSISSSKIDMGVNRIMQPDPEAINAVLQATNKDADTSTVATGADDARQGNQLLSIQNAKIQTVMKGLEKIDHGSNQVMDINSLMNAFDNYIKSITDGATIVGSPVHFYIKKLVKSDLIKMWQKRHLAEKSVTTAPPAADSDSPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUJ7</accession>
    <name>A0A654DUJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine protease Do</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="342" mass="36983" checksum="4880796AF53E697D" modified="2020-04-22" version="1">MKHLILLTILLLPNVLFGQSLSNLYKKVSPSVVVIEAKEKVENTDGKVSYMGSQGSGVLISDQGEILTAAHVVNNAENITVIFHDGQKFPAKVVRLATVTDVALIKLVYYDKNYPVAELGDSDVADVGDDIFIIGAPFGLEYSLSKGIISGKSVEKTRMEGFTFAEFFQTDAAINHGNSGGPMFNMKGEVIGLVSYIVSESGGFDGIGFAATINVTKQLVVDSDKRRWTGINGVLVDQELARLLNVPQPGGILIQSVVALSPAYMADLIGGNVPFYKDDQKISIGGDIILAVNDIPIVSEDNIIAFFKSILIKDEEALNSFKLKILRGGKVMEVILRFPENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DUP5</accession>
    <name>A0A654DUP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MARINOS108_10805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="270"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="303"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VXD12033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1032" mass="118102" checksum="9AE29C3174BB8D1B" modified="2020-04-22" version="1">MTESIINALVHLFAIIESVKEDNDVVDSGELIIKPYLSKLLNQELTNEYLRLFYDYLSFYREVNAEASDHILEIDSSSILQVAKICNQLNKELQSRERIIVFMQLLELINTDEKVIPRENEFISLVAMNFNLNAAEADSLKSFIIDPNGKGIDQDKAMVIDNKMTEWPEEVAWMMRKKSKKLPGASGFHHMYVENLFGKILVLHIASVDTYVFKYDGPLNLYLEGNKIVPRKFYLLKPGSIIKGPNIRSIYESEIIRQFVQERNKVKIVLAGEDLTYRFKNSANGIHKFSFNEESGNLIGIMGGSGVGKSTLINLLNGKLEPTSGRIHINGHTIHRASQEGVIGYVPQDDMLFEELTVYQNLHFNAQICFSDFSPTLLEKTVNKILDDLDLQDIKDLKVGDPLNKFISGGQRKRLNIALELMREPAVLYVDEPTSGLSSMDSEKVMLLLKELARRGKLVIAIIHQPSSDIFKLFDKLWILDKGGYPIYNGNPIDAVVYFKTMSTQVNAAESECTRCGNVIPDQILQIIEAKEIDDAGRMTNARRVTPNTWYEKYQTNLESKLKRIRFEERLPATNFHIPSLFHQFRIFSKRNLFSKLSNTQYILINLLEAPLLAFILGYFSKYAPSGEYVFADNKNLPVYLFMAVVVALFVGMSVSAEEIFKDRRILERESFLNLSRFSYINSKVVFLFALSGIQTLSFVLVGNYVLEIQGMTWYYMMILFSTSCFANMIGLNISSALNSIITIYILIPFILVPQLLLGGAMIKFDELHTGIAKQSHVPLVGDVMASRWAYEALSVAQFKHNAYESHFFEADKAMSQNSFQRSYLIPGLETATRDILRDSGAYESHQADFDLIQKEYDYLVEHFEVKTFPMIGSFSPALFSPSIGHRFLNYLDDLKDSFQVKYKDAVAKKDSIYESLIDQMGKEEFYQLKRNHFNESVSDLVENRNEFNKIIRSDNRLIQRKDPIFKDPYSHMGRAHFYASEKIIGDWHIDTVYFNVIVLWVMIGLLYLLLLSDGLKRTLGMFAGKKKNKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV10</accession>
    <name>A0A654DV10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Quinol:cytochrome c oxidoreductase quinone-binding subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="455" mass="51235" checksum="FC38239758A92752" modified="2020-04-22" version="1">MIAESAIREPLVTGGKTVHDVTEDIAGRVEEKPAKLWLFAMAISLGTLTIGAYAVAMTLWEGIGMWGLNKTVGWAWDITNFVWWVGIGHAGTLISAILLLFRQRWRMSINRAAEAMTIFAVICAAMFPVLHMGRPWLGFYWALPLPNTFGSLWVNFNSPLLWDVFAISTYFSVSLVFWYIGLIPDFATIRDRATNKVSAAVYGALSFGWDGAAKTWSRYETVALVLAGLATPLVLSVHTIVSFDFATSVIPGWHTTIFPPYFVAGAIFSGFAMVLTLLLITRKVYKLEDYITIQHIELMNIVIIITGSIVGVAYITEFFMAWYSGVEAEQYAFINRATGPYWWAYASMMTCNVISPQLFWFKKIRTNLAATFVISIIVNIGMWFERFVIIVTSLHRDFLPSSWAMFYPTMYDVGVYVFTFGLFFTAFFLFAKFFPVINMAEVKSIIKATGENKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DV33</accession>
    <name>A0A654DV33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_10868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="109" mass="12730" checksum="0D6D53FA3A925A0D" modified="2020-04-22" version="1">MNKNANIFRVKDLLTVAADVSFDDEYALKLNSKKLKSGKCQVKFYATIRERKDMYGYVLVDANKTLRDVVVTIKEKLHTIRQTREFHHLHLYSIGKSGRDDMNFIIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVS2</accession>
    <name>A0A654DVS2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_10749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="921" mass="105709" checksum="663AC29C63CF886F" modified="2020-04-22" version="1">MRATLKLLKETLGKPYEDLEYLLNALKEILLENGEETMASQIPWINDIPELASQELTEKHIQLYSLVFQLVNMVEINGAVQHRRSLEDQDLASVNGLWANNLQKLKAHNIDERDIAIRLKDIRVEPVLTAHPTEAKRATVLEHHRELYLLMVNRENSMYTKKEIANIRHNIKQTLYRLWKTGEIFLEKPDVQSELRNIMHYLINVFPEVIPVMDRRMIQAWEDQGFKAQTIYELNAWPKLSFGDWVGGDRDGHPLVTEQVTEETLKSLRLNAIVVIRRKLTDLVRHLSFTAEMDEVNADLKKRMLQIQSELGPRGDEAFSRNRGEAFRQFVNVLITKLPVDTRRGHATEIMEYPGCYVESKELLNDLKLLQKAMVEYGSKSIAYDDIHTAIRSVETFGFHLAKVDVRQNSAFHDKAMQQLLEAAGFEKTNYPEWSEEERMEFINQELKSNRPFTHQKIKLGPNAEAVVNCYRVLESHISKYGTDSIGSLIVSMTRSVSDLLLVYLLAREAGLTRQTKEGLVSELPVVPLLETIEDLENGPDIMRGFLQHPFTQRSLNHFKQKEELDKPVQQVMVGYSDSNKDGGIMASQWNLYKAQSRLYETGKNFDVKIRFFHGKGGSISRGAGPTHYFINSLPHSSIGGDLRLTEQGETIAQKYANKVNAEYNIELLMASTAATAILSQFTERKPHPLAHVLQKLADDSKTHYENLMREDGFIPYFREATPIDAIETSKIGSRPAKRTGANSLEDLRAIPWVFSWSQSRYNMTSWYGLGTALSELRDKDNKSYEEFKKVLVYDPFIRYVLTNVDTSLAATDEEVMTEYASLVSDTKLRDKFLNLFLGELALTREMLMDLLGKDIEKRRKNHYYSNQLRASLMMYLHKRQVKLLAKWRKEKAANDPAAEITQTQLMLTINGIASAMRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVX1</accession>
    <name>A0A654DVX1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="249" mass="29087" checksum="CF2717B8FC1C7A78" modified="2020-04-22" version="1">MFVLFSMVSLTSFGQQFKALLFTKVAGYHHEAVNEGVDAMRWLAERNDFALDWHQDASRVFNDKALAEYDVVIFLMTTQDILNDEQQEAFKRFIQSGKGFVGIHTASDTEYDWPWYNQLIGRMFYIHPHRQTAAIRVEDRNFPGMQLMPDMRWWTDEWYEFGEEKVDNLNYLITVDESTYDVKAKWGEKEAKGMNGFHPVAWYHDFDGGRAFYTAMGHMAETYSDAIFLEHIYGGIFWAATGKGVMKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DVY0</accession>
    <name>A0A654DVY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="68" mass="7545" checksum="33740A360ED3491C" modified="2020-04-22" version="1">MEKIKKFQIVNAILAFFGIGFIAIGFMVFSQQDSFVISLMITFIGCAMAISGIASMIELKLLSDKLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW24</accession>
    <name>A0A654DW24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/proton antiporter (CPA1 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_10557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="7"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="421" mass="46867" checksum="2762ADCE88C34818" modified="2020-04-22" version="1">MHIFDLIALIIFVSGLFIFLNTLYLKLPSSLGLMILTLILSVVILMTEILFPQWEIATEIKSFDFRDVLNQMVISVILFAGGLNMDINKLGTQKLPIIILSIVGAIISTLVIGTILYYVLNGLNIEISYMYSLVFGAVISSTDPISSSNTTKRFSLPKILEIKLEGESLFNGAFSVVLAFVLYHVAIVTGDQDITFVTFAQILLLEILGGITIGVLMGFIGFRLLKFIDNDDVHIEVLITIALVLVGSFISGFFSIYSKMVSLIMGLLIGYLSRGGANPVKKGEEIVGSYVYKFWNLMEETMAVMLFVLMGLEMLVLDWRMEFFAAGFIAVNVVLFGRWVSIFIPVKLMSGRFDFDKNTIPVMTWGAFRGGLPIALILALHNFPGKELLITMTYVVVVCSILFQGFTLPIMMRERFVNRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW53</accession>
    <name>A0A654DW53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">thyA</name>
        <name evidence="8" type="ORF">MARINOS108_10889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="2"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="264" mass="30273" checksum="E8E761DD0A649FBB" modified="2020-04-22" version="1">MKQYLDLMQYILDHGVEKGDRTGTGTLSIFGHQMRFNLQDGFPLVTTKKVHLRSIIHELLWFIKGDSNIKYLNDNKVTIWDEWADSNGELGPVYGVQWRSWPKSDGTTVDQLSGLIDTIKNNPNSRRMIISAWNVGEIEKMALPPCHTLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALFTMMIAQVCGLEYGDFVHTFGDTHLYSNHLEQARLQLSREVRPLPIMRLNPDVKDIFSFTIEDFTLENYDPHPHIKAQVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DW81</accession>
    <name>A0A654DW81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD11688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD11688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="473" mass="52960" checksum="5081E8014F5FC626" modified="2020-04-22" version="1">MQENRFKYEAIADNIRDAIRLGSLRTGDRLQSIRQTSRELGVSNASVFKAYYHLESEGLIECRPKSGYYVRYHLQDSEPPSSQLLNEDACEVSNQALILEFLATKLSHPDHLDLSTAVPSTELLPIGGLKKSIQKSYLNDPRAATAYENTTGHPGLKRSICQFGLNWGCVIAESEVVITNGCMEAIALSLSILTKPGDTIALESPVYYGLLQLIQHLKLKIVEIPADPTTGISLDDLEQVIHHQDLKAIVVIPNFNNPTGSLVPDENKQRLVAMATEHQIPIIEDDIYGELYFSEPRPKNCKSFDEDGWVIYCSSFSKTLAPGFRVGWCIPGRFHEEFVQRKYVTNISTSSISQAVIAHFLTHGRYDFYLKKLRSALKTQHLQYKRAIFDYFPGKIASSNPQGGFVLWLELSKNKNALKLYQVGVKAGIVIAPGQMFFARADYKNYFRISFGKPFDEAVDQALKKLGSLAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWH4</accession>
    <name>A0A654DWH4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaC</name>
        <name evidence="14" type="ORF">MARINOS108_11063</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="200"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VXD12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="515" mass="57030" checksum="029A235952FEBF54" modified="2020-04-22" version="1">MEGGKSSALKTTAKNRRLTVGDLSRQLGKVPPQAVEIEEAVLGALMLERDALTNVIEILKPESFYKDAHRMIFEAIVQLFNNSEPVDIKTVVHRLRKNGHLDIVGGAYYVSDLTTKVNSAANIEYHARIIAEQSIKRELIQISSEIQQDSYEDTTDVFDLLDKAQQALFDVSESHIRKNYDKMNALMHQAIQEIEDRKNQKDGLTGIASGFTSLDRITSGWQRSDLVIIAARPGMGKTAFVVSALRNAAIDFKTPVAIFSLEMSSVQLVHRMVSAEAELESDKLRRGNLQAYEWQQLISKTGKLSEAPIFIDDTPALSILELRAKSRRLVAQHGVSLIVIDYLQLMTGDTSKSSGGNREQEIASISRALKGIAKELNVPVIALSQLSRAVETRGGDKRPQLSDLRESGSIEQDADMVMFLYRPEYYGMTQDENGMPLQGIGEVIIAKNRHGKLENVQLKFIGKFTKFEDLDASISATNDTYGSSFPTTGPSNSDFTITIPSKANKKDGGDDEMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWR8</accession>
    <name>A0A654DWR8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_10827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="346" mass="38711" checksum="46C8445143E5F18C" modified="2020-04-22" version="1">MLFKFERQKLTIGELKSGKINQNILSNLESRVVKFIISWLTGQKEFAMPTSGSTGTPKETHLSREALQYSARQSMEYIDPTGSYQTTLLCINPDYIGGLMVVIRALTHDLDVSMVAPTSRLADVLGKECYDLVSMVPMQVQYLLDHHPDTLLQFKTILIGGAPLPQEYIIKLKSLKAVRCFQTYGMTETASHIALKNLTDGDDSFEVLGDTEIQQDSRGCLKIKGSVTDHQWIQTNDVVEMTDPRHFRWLGRADFAINSGGVKVHPEILEASLSSQLKMPFFVAGLPDASLGQRVVMIVESPEPVTLDFSHISQYSRPKEVYYSPGFSYTPSGKVNRTETLKKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DWZ8</accession>
    <name>A0A654DWZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane fusion protein, Cu(I)/Ag(I) efflux system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021782">
        <property type="entry name" value="DUF3347"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11827">
        <property type="entry name" value="DUF3347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="5">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="109"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3347" evidence="3">
        <location>
            <begin position="457"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="592" mass="65145" checksum="FB94C196AB57E64B" modified="2020-04-22" version="1">MKKLLQNKYVLIGLTLIIGGLIGWMLKPSTPASEMSEDHEHVADENGVWTCSMHPQIRKNEPGSCPICGMDLIPLESDLGMDDPMAIHMSPTALKLANVVTQKVGAGEITKTIRLNGKVMENEKLVYTQASHIPGRVETLNVNFSGDFVQKGQEISTIYSPELVTAQQELFETQKIKDKQPELFAAAKRKLTNWKLTNAQIDQILANGKPLETLPIRSERSGYVKEKLVMLGDYIKQGAPIYMIADLSNVWVLFDAYESDLAWIREGASVSFTISSLPGEQFTGKISYIDPVINPKTRVSKLRVEMNNPGYQLKPEMFASGVLSVTSHANKEGLIVPKSAVMWTGKKSVVYVKTASDQSISFRMRTVTLGPSLGESYVVKEGLEAGEEIVVNGTFSVDAAAQLAGKPSMMSPEGGAAMTGHNHGTTPESKEMNHSEINVSDKEYESDKAFQNQIKSVFESYLPVKDALIAADPDRASSTAKALLESLGKVDMKLVKGEAHMEWMADLTVLKAAANAIQKGSELETMRMMLSPLSDQLYHTIKKFKIETSGFRQFCPMAMNNRGAYWLSDSEKILNPYLGDAMLSCGNVEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DX31</accession>
    <name>A0A654DX31_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="130" mass="14501" checksum="73AE6DB45E28B99A" modified="2020-04-22" version="1">MKKTDSKEAPQSVDEYIADFPIEVQEILKAIRKVIQQAAPEATESISYGIPTFSQNGALVHFGGYKQHIGFYPAPRAIEVFKEELSGYEGGKGTIKFPLNKPIPMELVTRIVQYRLAENLNKSKNKKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXD4</accession>
    <name>A0A654DXD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_11605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="16893" checksum="ECD38E01EE1CB177" modified="2020-04-22" version="1">MCKSLFQAFRIFVRLKKVTSISLIFMLLLGNLGITFGTHFCGGRAIVSELMFGEKHLDCGMGMMDMPEAEHDSPHFSKSPCCENQYVSAEVDETLNKEVSNEAAQFFVAIAIATILYSIEFEETFDQPIPVDTSPQLGSPDYQVLHQVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXF6</accession>
    <name>A0A654DXF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MARINOS108_11752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024835202" evidence="5">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD14082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="324" mass="37235" checksum="1F195332033CC42C" modified="2020-04-22" version="1">MKYIIYSIMLLATSHLLAQNRQEIFLADPTIYQEKDTYYLVGTKNRPPLGFSVLTSKDLKNWAVPGNQGDSLYMILNQGDQTFGTKGFWAPQILKEGTTYYLTHTANEQTVLTKSHSLMGPFRQGEVGPIDGSEKNIDSYIFKDDDGKYYLYHVRFDHGNFLWVAEFDLKNGEIKLETLTKCFDQTEPWEATPNYESDPIMEGPTVIKLKDKYYLFYSANHFMNIDYAMGYAVADSPYGPWIKNEGNPILHRSIVGENGSGHGDLFNGPDGQLYYVYHVHYSEHQVTPRRTRIVPVIKTWNGKMNRYDFKVDADQIIVPKQVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXR4</accession>
    <name>A0A654DXR4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="326" mass="36705" checksum="B0DEF052357C24B3" modified="2020-04-22" version="1">MRKYILVCGGSGFIGTHLIKKLVNEGHKVLSVDISNPMHQESINFEFIQGDLRDYSKCMEIMKNGPFDEIYQLAADMGGAGYIFTGDSDADIITNSALININILKCCVTFDCKKIFYSSSACIYPQHNQLDALNPYCEESSAYPADPDSEYGWEKLFSERLYFSYQKNYGIDVKVARFHNVYGPFGAWNNGKEKAPSAICRKVAEATNPGTIEIWGDGNQTRTFLYIDDCLDGVQKLMDSNFHGPYNIGSEELISINNLAKMAMEISGKDLKFEHIEGPMGVRGRSSHNLKVRSDLGWQPETSLQEGLEKTFHWINHQVQEALQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DXS9</accession>
    <name>A0A654DXS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_11476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="53" mass="6233" checksum="BB049906C8C5B7D0" modified="2020-04-22" version="1">MSFIKEPKGVDFIIESEPLTEKDREEISKFIAEYKRKPKKSTGQKRATTHNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DY79</accession>
    <name>A0A654DY79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025060892" evidence="1">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="57"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="205"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="459" mass="52196" checksum="FB7B5B57B0E922EE" modified="2020-04-22" version="1">MRNYLVASMAVLLLAMGCTPQPDTPKEEGIFPYPIQQTKLDNGLNVVTVPYNSPGLASFFIVVRVGSRDEVEEGKTGFAHFFEHMMFRGTDKYSKAEYSEALKAIGAAANANTWWDRTVYHMTGNAEMLDKMFELESDRFMNLKYSEEDFKVEAGAVKGEYTKSYTSPYMKLYEKTYNTAFTTHTYSHTTIGYWEDVVDMPNQYDYSLEFFDRYYRPEYCTVLVVGDVTSDKVNDLARKYFGEWERGTFTQEITQEPEQTETRFAHVQEANFPPILNLNYKGPGFSVENKDMAILDVISSLAFSQKSDIYKKLVVEEQKVRELSAGGLNTVDPGLWSVDAMLVDKSDMAYVKTEIDKVLTDLKTNPVDSIALTQTKSFIKYSYAMGIDNPSDIANSLSWYIWLTGNPADVNKAFANYDAVTAEDIMRVANKYFVDEHLTVATISPDEELQVSEELNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYD0</accession>
    <name>A0A654DYD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin synthase sulfurylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeB</name>
        <name evidence="2" type="ORF">MARINOS108_11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="257" mass="28021" checksum="D39B865F82F836F2" modified="2020-04-22" version="1">MNEHYERYQRHFTLTEVGEEGQERLTRSKVLVIGAGGLGCPVLQYLVGAGVGHIGIVDGDQVSLSNLHRQTLYTSEDVGSDKSTVAGAQLAKLNPMVKISAYTEFLNLELALKLFPDFDLIIDGTDNFDARYLINDAAVITGRPFVSGSVFRHEGQVSVFNYQEGPTYRCLFPQQDRPGFGCAETGVLGPVTGVIGSIMAMEAIKVLLDIPGVLSGQLLILNALQWTSSQLSFSRKEEQVALAKTCVSHLQSFTHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYL0</accession>
    <name>A0A654DYL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside/pentoside/hexuronide:cation symporter, GPH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_11736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018043">
        <property type="entry name" value="Na/Gal_symport_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00872">
        <property type="entry name" value="NA_GALACTOSIDE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="246"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD14039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="462" mass="51691" checksum="AB042BD7C9702AA9" modified="2020-04-22" version="1">MNDLNQPIRLKEKIAYSFGDFASSMFWKLFSMFLLFFYTDVFGISAAAVGTMFLVTRVWDALNDPIMGLISDRTKTRWGKFRPYLLFVAIPFGIIGVLTFSTPDLSADGKLIYAYVTYTLMMMVYTAVNVPYGSLMAVMSNDGVERTSLASWRFIGAFSGGLFVTATANSLVEYFSQNSDQATGFQFTISIYAVVAAVLFMLTFLWTRERLAPPKEEKNSLKDDLKDLGKNLPWFIMLGANIFVLIFNSLRDGSILYYFKYYVKDQTLDFFGASYEVTSSVLSSAYMSIWLGTNIIGVLLAKPMAARFGKKTTFSYAALISAAFSFLFFFIQPDQLLLIFILNVFIGISAGIILPLGWSMYADIADYSEWKTGRRATGLVFSSSSMSQKFGWTIGGAISGYLLAGFGFEPNVEQTTEALLGIRLMISVIAGLGALISFGFMRMYKLDEKFMQKVKMELNANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DYP4</accession>
    <name>A0A654DYP4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_11811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD14215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="506" mass="56364" checksum="EB567E80435FCAD0" modified="2020-04-22" version="1">MVLDRRICSLVFFCLALTQCSPVQDTSSYKARLDIPALKSFTQSVVQTYPLPAMAVVVVTRDTAYYLTTGYSDLARKIPFTDSTVFFAGGFSELLVASTALRLQQVGKLSLQDPVVRELPYFQMQGDYQRISAHHLLTHTSGIPHFNPAWDMPAYEEDALEATTRSIIFQDVMFAPGTQCKRSPYNYDILADLMAKSEQKSFEEVVHAETLAPLGMRHSSFFPDTSSAELARPHEILNWISYDLRESEIYPYTRENAGSFGLHTTVGDMAKWMQMVLRTDTVQGGLSSASIDQLMTAHYKTGENTYKGYGWEIRDSEGMRVFHNSWNAGGFSGDLSVIPAEEMAVMVLSNTSDDFNPSVISEHILDHLHGASLSTVKYPIHIAMSRKLNEGRCLEEVLAWHDSLMMAGGGDYLMGPALLGQLGVNLLHRLSRMEDATEVFLHAVQLYPESPEAHLNLAEALLTSGLLAEAKTHFEEAMKLRPSMNSPYVSFLREQLAVAQENQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ13</accession>
    <name>A0A654DZ13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_11950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024837416" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="62"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="287" mass="32098" checksum="956A2DEA96700329" modified="2020-04-22" version="1">MKGFFFLIILLIWSSSVQSQYLVDSDRLQPDTITYKVMDTVALDMILRYPPKFKNRKKYPTIVFFFGGGWNGGTIGQFEPQAEYFASRGMITVLVDYRVKNRHQTTPYESVADAKSAIRFLREHAEELNVDPDKIAASGGSAGGHLAAACGVLPGLDEPDEDLSLSSKANALVLFNPVFDNGPQGFQKERMGARWREISPAHNITESAPPTIVFLGREDHLIPVSVAESYQSKMDSVGVRCDLFLYDEAGHGFFNNNKYDGKFYTLTLLETDKFLKSIGYIKGKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZ57</accession>
    <name>A0A654DZ57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_10871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024990616" evidence="1">
        <location>
            <begin position="20"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="36"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="835" mass="93992" checksum="CA3B1298D342E52E" modified="2020-04-22" version="1">MKKYIVVLLALGSMLGGHSQLKSPASFLGYEPGEQFSRHHQVVDYFQHVAEVSPQVVLQQYGESYEKRPLYLVFVSTKENLDKLETIRTDNLKRAGLLNGSPELSISVVWLSYNVHGNESVSTEAALTTLYELVRSGSDKAEWLENTLIVMDPCVNPDGRERYVNFYWQYANQPYNANPDSWEHHESWPGGRANHYLFDLNRDWAWQTQVESQQRMAVYNQWLPQIHVDFHEQGINEPYYFAPAAEPFHELITDWQRDFQTQIGKNHSKYFDANNWFYFTKQYFDLLYPSYGDTYPIYNGAIGMTYEQGGSGRAGLGVIKEEGDTLTLKDRIAHHYTTGLSTIEITSRNNEKVLSEFTKFFKQKAPSNYKSYVLKYDGNQGKFDALKGWLDTQGIRYGSASVSKPLSGYHYGSGKTKSFSIVAEDIVISTDQPKSVLTSVLFEPKTKLSDSLTYDITAWAVPYAYGVEAYATSAVLSVGASKTTSSELIQLSPAYGYIFKWENMQDARLLTAMLKEKVQVRFTTQPIQLEDKVFNQGSFLVTQRDNAKIRDFTNFVSNLSTQYGRQATPIASGFVSAGPDIGSADVRFLRAPEVALIGGPGTSSLDFGATWHFFEQELRYPVTTLSTEYFDRVDLSQYDVLIMQNGWYSDFGANTMNKISDWVADGGTLIAVQGALNKLADSDYSGLSAFNSEAEKGAFEDKDDLVKEELKLVPHADRERYDIREYVAGAVFKVHLDKTHPLAFGYGDSYFSLKTSASRYGYLSSGNVGVIKSPEDHLSGFAGQLVRSRVGSSLVFGVESIGAGHMIYMADNPLFRSFWQNGKLLFTNAIFYVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZE6</accession>
    <name>A0A654DZE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_12046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD14636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="142" mass="16085" checksum="E2688D233431125F" modified="2020-04-22" version="1">MKRSYWIYGGATGLLLLLLQVLHYRTMVRDLRLEVFGVVIAAIFMVLGVWVGIQLYKRRQATLIDQSRAQALQLSARETEVLSLLVDGCSNQEIADRLFVSLNTTKTHLSNIYQKLNVSSRTQAIQKVRDFGIISSPESTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZR5</accession>
    <name>A0A654DZR5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LuxE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047474">
        <property type="term" value="F:long-chain fatty acid luciferin component ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007534">
        <property type="entry name" value="LuxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04443">
        <property type="entry name" value="LuxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="323" mass="36595" checksum="037BA604BB79A643" modified="2020-04-22" version="1">MFDYENFKSKIFSIQPENFQTYALEVFVYQYLHNPTYQIYCQHLGKSPDNVHSLQDIPFLPIEFFKTHQVMTGKWKSEKVFMSSGTTGMQRSEHHVRDLGFYHKIAQVTFERLYGALQSIEIMALLPSYLEQGDSSLISMVDHFMSQAHPASAYYLGDHTSLQKAITSSERKKLLIGVTYALLDMADALSLSADDLIVMETGGMKGRRKEMIRTELHEVLMKNFAVEHIHSEYGMTELTSQAYAMGGQFAFPPWARALVRDINDPFSFLPVGRTGGLNIVDLANINSCAFVETKDLGLESKTGHFEVLGRFDNSDVRGCNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654DZT6</accession>
    <name>A0A654DZT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase TatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_120213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD16437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="254" mass="28731" checksum="D634163E07DD7A67" modified="2020-04-22" version="1">MILVDSHAHIYTKEFKVDIEEVISRAREAGVDRIYMPNIDHESIEDMLELALKYPGFCVPMMGLHPCSVKKDFEKQLYEVEEFLSKGGFCAVGEMGTDLYWDKTLFEEQKEAFRIQCELAIRHQLPIVIHCRESIDETIALVKPYADRGLTGVFHCFTGTLEQANEVIDLNFKLGLGGVATFKNGGMEPVIRGVALEHILLETDSPYLAPTPHRGKRNEPAYTKIVAQKIAEILDREVAEIGEITSQNSKTLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0A8</accession>
    <name>A0A654E0A8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="5">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">hslV</name>
        <name evidence="6" type="ORF">MARINOS108_120092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="5"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VXD16210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="181" mass="19551" checksum="7350861EBE462665" modified="2020-04-22" version="1">MGKVKIRSTTVVAIKHNGQVAIGADGQATMGNTVAKSNVKKIRKLQDGKIITGFAGSTADAFTLLERLEEKLATYTGNMKRAAVELAKDWRTDRYLRRLEAMMIVVDKGEILVISGTGDVLEPDDDIASIGSGSMYARAAAIALKRHAPDMTAEEMVRESLGIAADICIYTNHNLVVETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0E6</accession>
    <name>A0A654E0E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_12074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD14695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD14695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="45" mass="5394" checksum="11C41A36E0FD5A5C" modified="2020-04-22" version="1">MLSQSLKPLKIRIYFDSIDFFFRRTGYFGSSNIYVGYDYKDILQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0L4</accession>
    <name>A0A654E0L4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/2-oxoglutarate/acetoin dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MARINOS108_120194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="4">
        <location>
            <begin position="467"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="801" mass="89764" checksum="0C6B68CD8053871D" modified="2020-04-22" version="1">MSSVKTSKKTNLKKAEILADYALAIESREDSLIGRKEVFMGKAKFGIFGDGKELAQIAAAKFFQNGDWRSGYYRDQTFVMAIGQVTSQQFFAQLYAHTDVAAEPASAGRMMNGHFGTRSINAKGEWRTLTDIKNSSSDISPTAAQMPRLIGLGWASKLYRNNPNLKDFKDFSINGNEVAFGTIGNASTSEGHFFEAMNAAGVLQIPMVMSVWDDGYGISVPQKYHTTKESISKALAGFQRTENQTGIEIFTVKGWDYPALVETYRKAVKLAREEHIPCLVHVEELTQPQGHSTSGSHERYKPKDRLEWEKGHDCLLKMRKWMEEEGIATSAELDALEKEARAKAKKARENAWKDYMSEIKEDLNQAIELIGKAALTSNNNKILQQIKNDLKSSLNALKADIAKAVRKSLRYLTDNDSEEKKRLQNWLKEKQEKYRDEYNSHLYSQSAESPLNTEAVAPVFGEDSKLVDGREVVQACFDALFERDPRVIAFGEDVGRIGDVNQGFAGLQEKYGEIRITDTGIRELTIIGQGIGASLRGLRPIAEIQYLDYLIYALQTLSDDLASLHYRMKGGQKAPLIIRTRGHRLEGVWHSGSPMGMIINSLRGIHVLVPRNMTQAAGFYNTLMDSDDPALIIESLNGYRLKEKMPQNIGEIKVPLGIPETLREGTDITLVTYGSMCRIVMDAAQQLSEFDISCEVIDVQTLLPFDRNKDIVESLKKTNKIAFIDEDVPGGASAFMMQNVLERDGGYFHLDSKPITITAQEHRPAYGTDGDYFSKPSTEDVFEKIYALMHEINPERYKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0N1</accession>
    <name>A0A654E0N1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="397" mass="45577" checksum="80AC69F517CA38F9" modified="2020-04-22" version="1">MPNGLDIKDLELNALLEITQAINNNLAEEDLFRIYKFTLLADLKVQRLALYVKDDNWDCKVHFGTQTDWNKVFLPQFFWDLREVRELADCDEEFQAFELAIPVTHKDRLLAIVFVGGNERSGKKSNTTFLKALTNIIIVAVENKKLARKQLQQEAYRKELEIAKKVQNFLFPKELPKTHRLKIEAVYLPHQDVGGDYYDYLAIDNDRFLVCVADVSGKGVPAALLMSNFQASLRTLVRKTQDPKEIVAELNHIITDSGNAENFITFFLGIYDFHDKSFEYVNCGHNPLYLVTNDGIQELNDGTTILGMFDPLPFLKTVRIENLSDFFFFGYTDGLTETFNAADDQYGEERLKAFLEGGIPTDINKLHLDIFKSLDEFRVDVPYRDDITMLSCLVKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0Q6</accession>
    <name>A0A654E0Q6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">carA</name>
        <name evidence="4" type="ORF">MARINOS108_120469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD17066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="369" mass="40893" checksum="202E0545291A0987" modified="2020-04-22" version="1">MKQPERKKALLLLEDGSLFEGYSIGKTGTSGGEICFNTGMTGYQEIYTDPSYYGQIIVNTTPHIGNYGVHVDEDESAHPMIKGLVVNDFTHQYSRKTASEGLHEYLEKHNTVGITDVDTRMLVRHIRTKGAMNAVITSEIFDLDALKTKLSEVPSMESLELSSVVTTKTAYEVGQENTGLRIAVMDFGIKRSILKNFVERDCHCKVFPANATLSEMEAWNPDGYFLSNGPGDPAAMDYAVETVKGILVKDYPIFGICLGNQLLARAVDIDTFKMHHGHRGLNHPVKNLQTGKSEVTSQNHGFSVNMDSLKNSTTAELTHLDLNDNTVEGLRLVNKPAFSVQYHPESSPGPHDSAYLFDDFIQLIKDQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E0W9</accession>
    <name>A0A654E0W9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024997281" evidence="1">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="183" mass="19413" checksum="D402F1446016197D" modified="2020-04-22" version="1">MRNYISIAALAFLAFSCGEAGVGFNIGKEFPVSIPVDLPNGTPELIGTIPGDPPPVKRSEEYSLAGAGYDDLDALDAVEVIGLSFEITGVDDFEKFDLDGIEIDLVAQSGATIAQISVTTPQLSNVTKTSISNSAGLAALESALANQEDITTDVIFDFGEVPNEDVNFEFVLYFDVVAKVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1D8</accession>
    <name>A0A654E1D8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025011871" evidence="1">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="289" mass="33406" checksum="E3623A677D1AE9EA" modified="2020-04-22" version="1">MQTSKLLLILVFAAGVSNSCSQSASSPADPYLQKDWAKNALWDDGKAEVITYDAERVVYGKSRSFEYTYVLVKETFNKEYQVKTDAYNRNDLYEVMKINKFCRIPTMKYPYHYLTSVFLKRDNASLVHKLTNTSQEWCGNTAKSFVEDGNNYKYQYMSYWDGQGNGTDKLRKGPWFEDQLSYTLRTLNFEEGITFDILLYPMQISSRANLPEAEIATISITRTNAEDLSHIDPAFVSNPWKVNVSRAEGPDLSFWINGEYPNYLLRMEATDGRKLSMKSLIRDAYWAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1E0</accession>
    <name>A0A654E1E0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ORF">MARINOS108_120474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="125" mass="13810" checksum="13B77B3CFBC3B037" modified="2020-04-22" version="1">MARIAGVDIPDNKRGEIALTYIFGIGKSSAQGILAEAGVDPNKKVQDWNDDESGAIRTIIAENFKVEGVLKSEVQLNIKRLLDIGCYRGLRHRKGLPVRGQKTKNNARTRKGKRKTVANKKKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1I8</accession>
    <name>A0A654E1I8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="63"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="235" mass="27751" checksum="6209200D688F51FF" modified="2020-04-22" version="1">MAFDELVKQNLTNWQGRKEWFFNREHTDTYELWYEGRYKRAEIFQKKIIADRLQKDPRVKTLLEFGCGTTRFTRWWHEIGIEATGGDLSPFMLAQGRQLFGGDLVLADSHHMPFRDNTFDAVAFITTFEYYKDPVKVIREAARVGKHGIVFGMMNRNTPKYVRRRMQQMVGKNPFYVTANFYTPKSLLKVIDIALQGEDYTVEWQCTGLPKWFPVQEWHVPVGDFFGVYVKRNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1J9</accession>
    <name>A0A654E1J9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplP</name>
        <name evidence="9" type="ORF">MARINOS108_120490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD17117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD17117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="140" mass="15880" checksum="33E6058FEC3CA477" modified="2020-04-22" version="1">MLQPKRTKFRKKQKGRVKGIAQRGHRLSFGNFGIKSMEAGWITSRQIEASRIAVTRAMKREGQVWIRIFPDKPITKKPAEVRMGKGKGAPEYWVAVVKPGTIIFEASGISTELAKEALRLAQQKLPIKTKFVVRRDYTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E1N5</accession>
    <name>A0A654E1N5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="7">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Queuosine biosynthesis protein QueG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">queG</name>
        <name evidence="9" type="ORF">MARINOS108_20085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the QueG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="7"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00916">
        <property type="entry name" value="QueG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cob(II)alamin binding" evidence="7">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VXD18134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="308" mass="34914" checksum="D5F110D81DBC01C4" modified="2020-04-22" version="1">MNLQQHTALIKSLATELGFSFCGISKAGFLEGEAPKVEEWLRRGYQGKMGYLENHFDKRLDPTKLVPGAKSVVSLLYNYYPEKDQATDGKYKLAKYAYGQDYHHVIKDKLKVFMDQIQAKIGAVEGRVFVDSAPVHERAWAAKSGLGWIGKNSLLLNRQMGSFFFLAELIIDLELEPDGPMKDYCGTCTACQDACPTDAISEAYVVDGSKCISYLTIELKESIPPEFKGKMENWAFGCDICQDVCPWNRFSTPHNEPAFQPQGWEDFSAQDWEEMTQEVFSKVFKKSAVKRTKYEGLKRNISFLKNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F2</accession>
    <name>A0A654E2F2_9BACT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="VXD18058.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="71" mass="8600" checksum="EC840FD5B330FBF1" modified="2020-04-22" version="1">MEELTSLDIRDYQWVRDNYYLYDDPGDESEYMKLCEDLLKIDSTEFFLVIPDSLKQTAEILHVFNCNYVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2F9</accession>
    <name>A0A654E2F9_9BACT</name>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
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                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040807">
        <property type="entry name" value="DUF5522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17653">
        <property type="entry name" value="DUF5522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD18857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="51" mass="6021" checksum="78E4E47657302A50" modified="2020-04-22" version="1">MSQGKQPKGLAEEDYYFTKEGFIVFTEKYHLKRGHCCKSGCRHCPYGYKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E2L0</accession>
    <name>A0A654E2L0_9BACT</name>
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            <fullName evidence="7">ABC transporter permease</fullName>
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    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="260" mass="29255" checksum="FAB19AB60F0E2A70" modified="2020-04-22" version="1">MIKILKYSFSDLTRSRWSFIYLAFYLLLGSVLLFLNNDLSKGIITLMNVIVVLTPMIGTIFGVMYFYNSREFTELLLAQPVKRSVIFLGQYLGISISLSLSLVLGLGLPFLAYGLFRSGEIANFILLITSGTLLTFIFVALSICIALFNSNKIKGFGYAILMWLFFAVIYDGLVLLSMMVFAEYPLDNFALIASFLNPIDLSRIMILLKLDISALLGYTGALFQRFFGTSLGLIASWCMLLIWTIVPTVLLIRKAQRKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E342</accession>
    <name>A0A654E342_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein with beta-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_110038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000003">
        <property type="protein sequence ID" value="VXD15862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025665">
        <property type="entry name" value="OMP_b-brl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13568">
        <property type="entry name" value="OMP_b-brl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD15862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="199" mass="21256" checksum="8703DD3DB2ED204A" modified="2020-04-22" version="1">MRKIFLSAILVLATIVSYGQAKVELGLKGGLNLANINREDAQATYESATGYHGGAYALVKVANIGIQPELLYSTRGTQVSFDDISGDFKQEYTYLDIPVMLKLYAVAGLNIQVGPQFGVLLSTDGKISDGNGGTTSISKDSYKNADISAAFGAGWDAPFGVNFTARYILGLTDIDSGSEEAKNRTFQLSLGFRLFKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3C3</accession>
    <name>A0A654E3C3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="435" mass="47208" checksum="B614341643C57214" modified="2020-04-22" version="1">MTLKEHFSKNVVLAYPVVIGQLGHIMVSVADTMMVGRVGVIPLAAATFAGTFYHVLMLFGIGVSYAVTPLVAATKVGDQPRLMKYLQSGMVLNILLSVLMMAVGLLVSPFLQYFGQEEAVATAARPYLIIMCASMMPLMIFQTYRQFAEGLSDTFNPMVVSIFANLLNVGLNYVMIYGALGFPAMGLLGAGYATLVSRVIMAVLMWWMIRPRMKGFEWTFDWALAKKMLKIGVPSGMQYVFEVGAFATASIMVGWISAEALAAHQIALNLSAITYMCATGIAAAATIRIGNQMGLKDLKNLRIAGYTSFTLVAMFMSVSALMFILFRGELTGLYVKDAHVQSIAASLMIIAAAFQVSDGVQAVGLGILRGLTDVKVPTLVTFVSYWLLAIPGGYLLGFTFDLGIHGVWYALSGGLTLAGVLHILRFRRLTKRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G4</accession>
    <name>A0A654E3G4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmA</name>
        <name evidence="7" type="ORF">MARINOS108_20114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD18200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="88" mass="9546" checksum="1595F476FA91B2AA" modified="2020-04-22" version="1">MAHKKGVGSSKNGRESESKRLGVKIYGGQKAIAGNILVRQRGTKHHPGENVGIGRDHTLFALIDGTVRFRKGRQDRSYVHVDPAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3G8</accession>
    <name>A0A654E3G8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">aGPT-Pplase3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041271">
        <property type="entry name" value="AGPT-Pplase3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18746">
        <property type="entry name" value="aGPT-Pplase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="aGPT-Pplase3" evidence="1">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD18947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="313" mass="35774" checksum="9E43B5EB4E028DF7" modified="2020-04-22" version="1">MKRFDPILVNQLKQQLEKFDNEVFPLPGIADGDNMECFIKQVIDSIRRVKYVTTIKEKPLTGHCTNALSVGFNPIMAASWHLRNGDIDEAMWLVFLLTYFGKSKSSGWRLMRGFYSGLGSSPAYWTWKHAYHNKEDLEAWLLERAEEVKSLGVFSNHRRYTSFKANSKKGPLFVFSNYFKWVGNNGSHIAKFDSLETLSKEADNPLFKVFYDSIPSGLSMNRLGKFDFLTMISKLGIVNMIADSTYMKGATGPLPGAKLLFWGSGKIDVNIKEIQMRMDTLASYLGYQHAMQILEDSVCNWQKDPSNYKWFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Q2</accession>
    <name>A0A654E3Q2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD18421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="276" mass="30954" checksum="318EC7CEDED075ED" modified="2020-04-22" version="1">MKKILVPTDFSDCARYATDTAMQIAKRAGAELHFYHHIFVPVDWVVVDFGHGSSLPDISEEEKGVLEQLKNLESEAFSQGIKCVTHMDYDTSSESITRYATAQDISLIVMGSHGAKGIKEFFIGSNAQNVVKHANIPVLIIKNKPVIRDSPTVLFASDFHTEALNAFRLVAKYAKKIGSKIHLVYLNTPAEFKRSWVIRDRMDQFIDIGSDSLAKAEIVDCLFLEEGLQNYCEENEIELLAMATHHRKGLPRMFMGSITEQVVNHMEIPVVSIPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E3Z7</accession>
    <name>A0A654E3Z7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_20650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="151" mass="16755" checksum="6B804024245A7A18" modified="2020-04-22" version="1">MELHTLKLKVHEVCLDLIQSRIDGLNNELRGFQAAANEESKSSAGDKYETGRAMMHLEKEKVASQLNQVLKQQKVLRELHPERKSEKVELGSLLSTDQGLFYISISLGLIQTPEKVFCISPVAPLGAAFLEKQVGDLVSFNGKSYKIGEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E446</accession>
    <name>A0A654E446_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative outer membrane starch-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MARINOS108_20853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033985">
        <property type="entry name" value="SusD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14322">
        <property type="entry name" value="SusD-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD-like_3" evidence="6">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="261"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD19755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="509" mass="57176" checksum="F773ACFC708D8D4A" modified="2020-04-22" version="1">MKKIFIYIAIIGGGCFGCEDKLDIENPNEPNVGLFWETGEDAEKGVNAIYSTLHKGSISRWMPMLYSTRADIGESRSPWTDLSNALDKFIQPDYNFDPVSGVFADNYVGIFRANQVLDNVPGIDMEKSEKDVLLGQAYFLRALFYYHLATLYGNVPMLLKTSEPQDYPPNSTQAEVFEQIISDLELAVPMLPARYADAADLGRVTKGAAYALLAKAHMQLGQYQAALPALQWLVDGEGGDIYNLVANYRDNFLITTENNVESVFEWQFAENPNEFTDNDIQTPNHNYGTSLAQFTAPVGIGWSDAEARRWIIYEFDELTVSGDRDPRVAASFLFDSTDINGPDATMIYGQSFSSRYGTGPDSKRVWVRKFLNDHWKNQEGYRSPNNYRYIRYSDVLLMYAECLNATGSTAAAYPHVDRVRQRAGLQSLSVARPGLNQAAFLEQLKHERLLELAGEGHRWNDLARWGDLGPGLAVNDPAFANFEVGKHELLPIPQLDIDANPNLEQNPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4E9</accession>
    <name>A0A654E4E9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_20973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="104"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD19936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="201" mass="23295" checksum="A8EC3DCD0A725821" modified="2020-04-22" version="1">MPLLLSKPISPYSAYAVWNIQETNQVLLGLIKEDVPEGLNPTRLAEWIVGRILIQNLCAQFALKYRGLTPNESGKPFLIGSTAEISISHSFPMAAAMIHLHNPCGIDLERARNKLIKIQDKFINEREIEYRDNLQKLCAIWCGKEVLYKIYGRRKLSMRDETFIEFETDSVMNGIIQKDQMELHYRIHYEAVRDYFLAYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4F6</accession>
    <name>A0A654E4F6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_60031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="39"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="348" mass="40160" checksum="A0453B1BFE74036F" modified="2020-04-22" version="1">MRAHWFYYLVKVASWIGLKLFFGGVKIYGAKNIPRDAALIFTPNHQGAFMDAVLVGTFNRVPVSFLTRSDVFNKWSMPFLKALNMMPIYRIRDGIASLSQNDAVFDTCFRMLSEKRAILIFPEGNHGIEYYLRPLSKGTARLALDARAQVDPNTKIYIIPTGINYFSHYRPLAKVLIKFGEPIELEDYMAQYHEHKQKGYNQLKQDLAEAMKKTLILAEDGTDYTQKRDWIFQPKHEHLSFDELKTMAEGDHFEAREPMKKGPVRKALIWILSIFNLPPMLGLSKIIRGIKDHVFYVSIKYMVGSFLHILWWSFLFAAGVIWIGWEAGLLFAFTAIMVAMARQSLIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4I8</accession>
    <name>A0A654E4I8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfoX_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_120412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000004">
        <property type="protein sequence ID" value="VXD16897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD16897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="108" mass="12222" checksum="B65728E8038C35B4" modified="2020-04-22" version="1">MAYSESDLNFILDQLSGIPEISHKRMFGGIGFFHQDRMFGMIGGGTFRLKVDESNLADYKTRGMTPFTMGSQGKELPYWEVPLDVLEDRSLLTEWAMKSVAVAHKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4L6</accession>
    <name>A0A654E4L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="62" mass="7023" checksum="D622011B2B669966" modified="2020-04-22" version="1">MPKSMAASNAPNERTNMNVETGRRNMHENLTNAKIHRLTEVLARVCGFGFFTDIYKCPAYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4P2</accession>
    <name>A0A654E4P2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PS_pyruv_trans" evidence="2">
        <location>
            <begin position="13"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="363" mass="41918" checksum="DFE48E8019E31BD7" modified="2020-04-22" version="1">MRLFVIGHYGGDNLGDELMLHGILHELQKKPKVKSIRVVTKKAPPASTWKVKYIGLGLRELIRGIFWSDTLILGGGTHFHDDYNDQRYSRHRLYLLRIFLITLIFRIFFKKVYYLGMGFGPFNRKSVQLMTRMSTALTTGITVRDIMSKERLSTIGVDTKSIPINFDLAALHPSFSVRDKSPQGLDLGISITSLEYSGVGVNDEFWYEVIFEELLDLYQRSDIVIRIFVFRTGEKESDYLLSKVLYQKLYAHDSSRTTIQTPNSIDRFLCEMRSCKYFIATRYHSAVTSFLSGCNILIVPYHAKLTDFTDSVGLDRGSICNFEERTIFKRKLKELCNNNSRFIPKLEISQAIKSAENNFLFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E4T6</accession>
    <name>A0A654E4T6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RecD-like DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MARINOS108_20861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="181"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="199"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VXD19763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="611" mass="69356" checksum="870B1DBE8D389678" modified="2020-04-22" version="1">MSVLDDFKQAIVIQQQKDDEAYEEQIALPLDERVAKGVTMTNLKVIFDFYEEAPNQWCPHLNYPYKFLRSAEIFSDNNISKFREGAQVVLSNGSHEFKMDILEDTLERFVLAPNDYDVKACYLDSKSYNQNNWEINVVKTDLTLKLLSATAGNLESDSARLNKIERLFSGALTNPINSDKCYNGLNDSQNTAVTKAVLSPNFHLIQGPPGTGKTETIAHIAALYLRSGKKVFVTAPTHTAINNCLNAIANRVKEDSKVVKIGEKYQAAEILTNPHIKRKTRLSLESFESVNEMSKEGIVIGGTPYSLCYPASKRLNNWEFDVALIDEAAQMSIPLAVSVMSKTNKFVFVGDHEQLDPIMPSGTGVSMFSESVFRRLVRLYPNDKTLLNISYRLNDKLIRIPNKLFYSDQLTSGVSPNIENSQIPSNHYSEVLNNEDPKVLYLHKVFDSQGRSPHEASIVAGILKDLVEHGAELRDIGIITPYRAQVREIKKALNRVVKGIDTERTESLFIDTVDRMQGQERDYILYSMSNSHPLESKRRLDFFYSPNRLNVAITRGKKKCIVIANYKVFDIIDDELSDLPEYDNLKPSLNIFKEYFRLSTKIEEEVEEDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E504</accession>
    <name>A0A654E504_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_20694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD19333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="180" mass="20560" checksum="A2C4E49A66251ADD" modified="2020-04-22" version="1">MEKNPWKKQSGKLIYDNPWITVEEDMVINPGGGLSQYGKVLFKNFAIGIIPLDEQKNTWLVGQWRYTLGEYSWEIPMGGGPKEESKLESAKRELKEETGLSARKWTELLKMHTSNSVTDEVGYAFLAEDLTEGETDFEETEDLKIWKLPFSEAHQMVLDGKITDSLSMVAILKLGRMLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E543</accession>
    <name>A0A654E543_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">argC</name>
        <name evidence="7" type="ORF">MARINOS108_90086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="345" mass="38632" checksum="3BA7926D313D309F" modified="2020-04-22" version="1">MSKYNVAIVGATGYTGSELVRILINHPDVNITAITSESRKGELFSDVHPQFKDIFDLTLVGIDDLEEEGLDLVFLALPHGVSMDFVKDNHHKSFKIVDLSGDFRLSSKAVYEAWYQKDHHFEQGFDQAVFGLPELYRKRIREARLVANPGCFPTSAILALAPLMKEGIIDRNQITVDSKTGVTGAGIKSKPNTHFPMVNDNFSAYGVKSHRHTIEIQEIVGKYANSEATVLFTPHLLPVDRGILSTTYTKPTREISTPELENIFREYYENEPYVRLRSELPNLKQVRGTNYCDIFTTYDDRTNTIITISVIDNLVKGAAGQAVQNMNIMLGLDETSGLHISPLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E564</accession>
    <name>A0A654E564_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_50038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="420" mass="46294" checksum="C595EA0FC3060413" modified="2020-04-22" version="1">MIWKNQTFQILIVGILLTSCDAFQEDVAPKGEDELVLTEGISALPNTPVFIDLKKTIRSSEAVRFSIGAAPNKGSATISDQAILQYVPNNDFTHGQDVVSIQLLNGVGQLIDTDSLLITMATSADSLPCFNGALSDYYSVSKNTSLIIYPIANDGYCVESTSGAVIDFMEEPAHGSLSQVELFTYRYTPEADFVGREQFMYELTLIDNEGATFYSIGQVNIEVTETSFGCDTMVYPLTYEMPDSLSYLDVLPFAPSPVCEVFTWTVHLKSVTSGSAEVLNSGLIRYYPGTDSIDVIDYSISFGDQTFHNQITIIIEGRTDDQCLEAIYDEYQLSITKDSLGTRDHPYILNVAENDITCSTDYTLQIVIEPEIGVSSVNAEQMIEYYVENFESDSTETAFLYQICAGGACDTAHVSLMLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E5F4</accession>
    <name>A0A654E5F4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MARINOS108_50054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000010">
        <property type="protein sequence ID" value="VXD20595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="33"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VXD20595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="288" mass="33521" checksum="14660836D4749E9F" modified="2020-04-22" version="1">MVLFLAVALFEPYIYLHFLTSPVIDKSLKKEHFDIIAHKGASGIAPENTMAAFRAAIEMGVDMIELDVRNTKDEEIVVFHDEFLDRTTNGTGAVHDYTLEEIRQLDAGSWFDPKFRDERVPTLKEVLDLINGRCKVLIEIKHMDHPHYHDFAEKLVDVIRQEKNGYEWIILQSEEVEYIEAAHEYDDHVQTKKLMIGEDSAPLIAFYVETKMHLGRAKEDDRMKALNPEYHTLSTRRVFRMHARGFQVYTYSPNNREDMVKMLHMGVDGIITDYPQILIQIRKDIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E6A3</accession>
    <name>A0A654E6A3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">katG</name>
        <name evidence="12" type="ORF">MARINOS108_11467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="CABWNM010000001">
        <property type="protein sequence ID" value="VXD13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="143"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)" evidence="8">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VXD13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="744" mass="81426" checksum="1C4EC277CED3A396" modified="2020-04-22" version="1">MENSKHSGASVGDMNDASKCPFHGGSLKQGAGGGTSNRDWWPNLLKLNILRQHSSLSNPMGEDFNYAEEFKKLDLKAVKKDLFELMTKSQDWWPADYGHYGPFFIRMAWHSAGTYRISDGRGGAGSGTQRFAPLNSWPDNANLDKARLLLWPIKQKYGKKISWADLMILAGNCALESMDFKTYGFAGGREDVWEPEEDVYWGSESEWLGDKRYTGDRELENPLGAVQMGLIYVNPEGPNGKPDPVAAARDIRETFGRMAMNDEETVALIAGGHTFGKTHGAADPGKYVGPEPAAASIEEQGLGWKNTLGSGSGVNTITSGLEGAWTTTPTKWSNNFFENLFGFEWELTKSPAGAHQWKPKGGAGAGTVPDAHDPSKSHAPFMLTTDLALRMDPIYEPISRRFYENPDQFADAFAKAWYKLTHRDMGPLARYLGPEVPSEELSWQDPLPAVKHKLVDDKDIAALKGEILDSGLTVSQLVATAWASASTFRGSDKRGGANGARIRLAPQKDWAVNNPKQLAAVLQKLEGIQKEFNSSQSGKQVSLADLIVLGGSAGIEQAAKNAGHSVTVPFTPGRADATQEQTDVESFAVLEPGADGFRNYFEPKHQASAEEMLVDRAQLLTLTAPEMTALVGGMRVLNTNFDQSKHGVFTKRPETLTNDFFANLLDLSTTWKATSASEAVFEGRDRATGAVKWTGTRVDLIFGSNSELRAIAEVYGCADSEEKFVQDFVKAWTKVMNLDRFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E722</accession>
    <name>A0A654E722_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MARINOS108_90098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024837417" evidence="2">
        <location>
            <begin position="38"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VXD21391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="1425" mass="163513" checksum="D90159744A8277E6" modified="2020-04-22" version="1">MSRHLIFKQAMISPKMYLRKSCVIALLFLFVSSATQGQTWEVLLKKAEKQYNKGKYAKVEKALTKLRSKHIAKKYKGDSSLYPLTYIMGARADYAMADFKGMEGNFNIALKSLPKWKNGHTYNYTMGMLRVIDFYNEYGNHRKADSLTSILEGLSTAYLQNDILAQEIKMRRAFTDVAMGSYDEALISLKELIAAWPTKLKLSYSFEAIKAEDEAYKTQLLVDLFTAEIEAYRGKGEYQKAIELLETRNKQVNRLVEATTEAYVDFRIAETNVYLDYGDATKARKVSDQILTVKPKGKLFEKAGFANIIANEREGRFGDAVTTSMKVETALIKAKVSREYAYFNTEFLNTLMRSYERDTKQNIVMRFNSLISRTANLLPEDHKTMTLALENGIQYIFDIQRSENYPLAEKFYIKLGESLNTRYGKRALQTNIYQINFAGYYLKYSENPARAYKLLAGEVYKKPLTQLSTQHPDYARIVTDLMEYFTLTGNFDYPIALTKTVVEAMVANPNTTNSELGEKLVALARLQIQGGYYKDAELNADEALKVLRRGGERKSEEYVKALNSAAFLYGTIGLYNKAENQLRKSESIYKKIATANQELRLESIVDLAFLYTRMGNYSETEELVNTAIAERKKLYGSSSRRLIKPYSALGEVFMIRGDYPESEKNLRAALSIAETVYGDTTLIFAETLSKMVKLYLDLGNYEAALVNATDVLKIREKTLRPDHILFADTYTDLGHIHYNLGSQLQIVDKYYQLAKEITASNFDEKHPLYAEALKNIAFVHIQRAEYDVALALLDQADDIWRDALANQNRSSGEVARIKGDIYNYQGKFKEARREYEKAAKYFKRIFSEEHPDFLNTQSRLARAYYINDEVSKVESILSETTLAYLNYTKTYFPTLSEDEKAKFWNKIKPDFEFYNTVAVRYSASKEKYLENMYDFALATKGLLLNSSIKTRNSILHSGDQKLITLFKTWVSKKEYLTTTLAQSSEDASETEIDIKKLKDEIAVLEKQLSESSDTFEDSFEYKLYTWDDIRKSLKDNEAAVEIIRYREFDDQFNDEKIRYAALIITSETRKNPELVLFEDGNEMETRHFMYHRNITKYKLTDANSFGVFWEPIYNKVKDKEIVFLSPDGIYNQLNVESFKINETEYVIDKMNVRVVNNTKTIAALRSREAKKVKKAEEPREFTAMLLGNPNYYITDENRKTAQREANRGGANVYVPQLPGTEQEVITINDLLKTKGWKIEYYLGENATENQIKQSQNYTLVHIATHGFFDDKAKKEKRPEFMIEEDDNPLDRAGLLAEGGGDVLVKATKNYNIDDGILTAHEAMNLNFDKTELIVLSACETGRGEIQQGEGVFGLQRSFLVAGADAIVMSLFQVSDEVTQKLMVEFYKNWLNGQDKRTAFNNAQLTIKAQYSDPIYWGAFTMIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E7K9</accession>
    <name>A0A654E7K9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chaperone CsaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csaA</name>
        <name evidence="5" type="ORF">MARINOS108_20688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD19324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008231">
        <property type="entry name" value="CsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="PTHR11586:SF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02222">
        <property type="entry name" value="chap_CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VXD19324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="110" mass="12292" checksum="132EE748EEFFEE75" modified="2020-04-22" version="1">MITWKDFEQVDMRVGTVVRVENFPEARKPAYKLEINFGPEIGTKKSSAQITDLYKISDILGKQVIAVVNFPPKQIGPYISECLVMGIYNQNNQVILLQPERAAPNGAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654E961</accession>
    <name>A0A654E961_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SusD/RagB family nutrient-binding outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_60004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000011">
        <property type="protein sequence ID" value="VXD20757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041662">
        <property type="entry name" value="SusD-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12771">
        <property type="entry name" value="SusD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD20757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="476" mass="51729" checksum="BCD607EFB26B6538" modified="2020-04-22" version="1">MKLPSIFILSLLGVGILISCEGLVEGLNDDPNNPTTASYQNILTGAEVGNIILQTGETARRAGIFCGYYTGIQRQHQGFDSYTVTTSDFDNLWDDAFVNTLRNAKEAQEAAAQEGIEGVTAGIAQVIQAMAYGTEASLFGDIPFDEAADISIEHPKFEAQVQVYQKIHLLLDEAILNLSTGTGRPTSGSDIFFDGNPDAWTEVAYTLKARYFLHVKNYEAAYAAAANGIQSMASSLYAPHGSGADESNLTYQFFAVQVRGADLITSDFMTSLVAPDPATNPQIANYRGNTKTNETGRYKFYFQINDVGTQPNTISGLAAQEASAPMVTYQENLLILAEAGLRSQSFGIGLSHLNEFRAFMSTGGYLTSASPADILYDPYVSADFDNGGMENPDGLSSENALLREILQERYVTLFGQIEGFCDTRRTLGEGTVRVPVAPNTGNELPQRFIYPQSEIDRNKNVPNPIPGFFEATMVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654ECU9</accession>
    <name>A0A654ECU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MARINOS108_20487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000007">
        <property type="protein sequence ID" value="VXD18961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="248"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="634"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VXD18961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="795" mass="89406" checksum="CB7699FFB2A3C6D5" modified="2020-04-22" version="1">MWTRLANIILKYRISLMIILGVITIYMGYQAQYIQWSYDMANIVPEDDPDQEYFRQFKQTFGEDGNILALGFKDSAIYQSDNFKKMKYLTRELESINGVKDVLGLANLKMLEKNNEKKRFELVPVFPEIPENQAKLDTMLAFAKNLKFYSGQLINAKNGATLILVTVEKEALNSEYRHIMVADIVRAGDQFHDATGIDVNYAGLPYVRSVNTLKIKEELNRFLIYSVIITGLILFGFFRSLKAVVFPLIIIGMIVVWVLGTISLLEYKITLLTGLIPSIIVVIGIPNSVYMLNKYHHEYSTHGDQMKALTKIIKNIGIVTFITNFTTAVGFFVLVFTGIPILVEFGIVAGINIMCTFIVSTIMIPSVFSLFKPPTSRHLKHLDFKMLNGALVGLDVLVHNHRKLIFITTGILVAVSVYGVMQLQSNSYMVDDLPEESPLAKQLQFFEENFSGVMPLEVIVDTGTKKGVQSLSNLRKINEFEMFLDSLKGISQPVSVVSFIKASRQAFYNQDPAFYSIPNNRESAFILRYLKEESDEGGIAKSFVDSTGQFIRISLKMPDIGSNKMDSLVNTVISPKIDEIFADSKMDVKITGTVPLFIKGNKYLIDNLITSMIFAFFIIAVIMALLFKNFKMIVISMIPNMIPLLLTGAIMGFFGIPLKPSTALIFSIAFGISVDDSIHFLAKYRQELHAHNFFVPIAVSRSLRETGASMIYTSIILFFGFVIFTLSEFGGTVALGKLTSITLLFAMLTNLIVLPALLLQFDNGKRNKKDHPYIDDFAKADYDSEDEETEEDKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFM7</accession>
    <name>A0A654EFM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MARINOS108_90111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="VXD21428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="488" mass="56333" checksum="52B70F4C2D1CBCDC" modified="2020-04-22" version="1">MRTHLTFFSAIIGLSALVACKTDKKEEPNPQTPEEVVFAVETGESQLPYLIIDTKGVDIKNEPKIPAELKIYVEKAAVQSAHIGIEYRGSTSFRLSDKKSFGIETWAEDGSDTEVSFFGFPEEEDWILMGHVVNEGQGYIFDRTLMYHQFGYRLFEAMGRYASRTEFVELQIDDDYKGVYVFMEKLKRDKNRIDIKKLEPGDVLADDITGGYILKIDKTAGGDLNINQPLEYFENNWEDDARYTEDISFRSDYDIYGQPIEFDPYGQPYHADMYLETYFLYEYPKATEITATQKNYIQAYISDFETALLTDDFSTEERTYTDFVDLSSFVDFFLLNEVVRNVDAYRLSTYLHKDRGGRLNMGPVWDLNIGYDNGGRVPIDGWVMNYNQYVESDAWMVPFWWPRLMEDPKFRTAVKIRWNSLRGGIMSTASLKAMVDATASYLIENGAVDRNYDRWGKAIGVDYDASIASLKTYLEERTQWMDGQISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A654EFP9</accession>
    <name>A0A654EFP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nucleoside transporter YegT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yegT</name>
        <name evidence="7" type="ORF">MARINOS108_90141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Marinoscillum sp. 108</name>
        <dbReference type="NCBI Taxonomy" id="2653151"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Bacteroidetes</taxon>
            <taxon>Cytophagia</taxon>
            <taxon>Cytophagales</taxon>
            <taxon>Reichenbachiellaceae</taxon>
            <taxon>Marinoscillum</taxon>
            <taxon>unclassified Marinoscillum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Karimi E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Marinoscillum sp. 108</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CABWNM010000014">
        <property type="protein sequence ID" value="VXD21498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000437459">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004740">
        <property type="entry name" value="Nuc_H_symport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03825">
        <property type="entry name" value="Nuc_H_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="167"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VXD21498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000437459"/>
        </source>
    </evidence>
    <sequence length="407" mass="45293" checksum="C02D3ADB9633D29A" modified="2020-04-22" version="1">MNQIKIRLSAMMFLQFFVWGSWFVTLGTFLGNNLGATGSQIGMAFSTQSWGAIIAPFVIGLIADRYFNAERILGILHILGALLMYQMYVSADFTAFYPYVLAYMITYMPTLALVNSIAFRQMENPSEEFSKIRVWGTIGWIAAGLVISYLFSWDAPGAISSGLLKNTFIMSAVSSLILGLFSFTLPATPPGIAKGEKLLLKDILGLDALRLLKDRNFAVFFFSSVLICIPLAFYYQNANPFLSEMGVANPTGKMTIGQVSEVGFMLLLPIFLSRYGIKKTLLFGMLAWVLRYLMFAFGNNEELVVMLLLGIALHGICYDFFFVSGQIYTDSKAGDKFKSSAQGMITLATYGVGMLVGFWVAGQITDFYVLEAGHDWRGIWVVPAGFALLVFFAFMLTFRSEDIKYEK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>